Grant List
Represents Grant table in the DB
GET /v1/grants?sort=title
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=title", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=title", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=2&sort=title", "prev": null }, "data": [ { "type": "Grant", "id": "7483", "attributes": { "award_id": "3R34DA050342-01S2", "title": "\"1/6\" Planning for HEALthy Early Development Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 161000, "principal_investigator": { "id": 23285, "first_name": "Lynn T", "last_name": "Singer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 497, "ror": "https://ror.org/051fd9666", "name": "Case Western Reserve University", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 497, "ror": "https://ror.org/051fd9666", "name": "Case Western Reserve University", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.", "keywords": [ "2019-nCoV", "Address", "Affect", "Age", "Alcohol or Other Drugs use", "Alcohols", "Antidepressive Agents", "Area", "Behavior", "Behavioral", "Benzodiazepines", "Brain", "COVID-19", "Child", "Child Development", "Cognitive", "Collection", "Communicable Diseases", "Communities", "Coping Behavior", "County", "Data", "Development", "Diagnosis", "Disease", "Economics", "Emotional", "Employment", "Enrollment", "Ethics", "Family", "Frequencies", "Future", "Government", "Grant", "Growth", "Health", "Human", "Individual", "Infant", "Interview", "Knowledge", "Link", "Longitudinal Studies", "Marijuana", "Measures", "Mental Health", "Methamphetamine", "National Institute of Drug Abuse", "Ohio", "Opioid", "Outcome", "Participant", "Pharmaceutical Preparations", "Phase", "Population", "Pregnancy", "Pregnant Women", "Protocols documentation", "Psychological Factors", "Quarantine", "Race", "Recording of previous events", "Reporting", "Research", "Research Personnel", "Research Proposals", "Risk", "Sampling", "Schools", "Severities", "Site", "Smoking", "Social Distance", "Social isolation", "Social support", "Socioeconomic Status", "Standardization", "Substance Use Disorder", "Symptoms", "Target Populations", "Testing", "Tobacco", "United States", "Virus", "Vulnerable Populations", "Woman", "Work", "comparison group", "coping", "coping mechanism", "design", "experience", "food insecurity", "improved", "neuroimaging", "new technology", "offspring", "opioid user", "pandemic disease", "parent grant", "postnatal", "pregnant", "prenatal", "prenatal exposure", "prospective", "psychological distress", "recruit", "research study", "response", "social", "stressor", "vaping", "working group" ], "approved": true } }, { "type": "Grant", "id": "9515", "attributes": { "award_id": "5R44GM133222-03", "title": "\"Blueprint of Life\" Genomic Literacy Tool: An interactive to enhance genetic and genomic understanding with middle/high school students and their teachers through personal genetics and human disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-01", "end_date": "2023-04-30", "award_amount": 760910, "principal_investigator": { "id": 25223, "first_name": "Sally", "last_name": "Reidy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1840, "ror": "", "name": "D'VINCI INTERACTIVE, INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 25224, "first_name": "Mason Evan", "last_name": "Scuderi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1840, "ror": "", "name": "D'VINCI INTERACTIVE, INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The increasing prevalence of genetics and genomics information in modern life calls for an equally relevant and engaging solution to teach the next generation. Additionally, educational interventions that help close the participation and achievement gap of underrepresented demographic groups in STEM are sorely needed. In this NIGMS Phase II SBIR project, d’Vinci Interactive, in collaboration with The Jackson Laboratory, proposes to develop and evaluate a full-function prototype of the “Blueprint of Life” online educational solution, which is aimed at embedding genomics into middle school and high school classrooms. The solution will feature an expanded, NGSS-aligned supplemental curriculum that teaches key concepts around molecular genetics of personalized medicine, use of bioinformatics tools, the viral genome (particularly with regard to the COVID-19 pandemic), careers in genetics science, and the ethics of genetics research. The curriculum will be delivered via an online student learning portal designed to provide learning experiences that are engaging, inspirational, accessible, inclusive, and relevant to students’ lives, with features such as an immersive 3D/VR genome exploration module and an immersive Virtual Laboratory environment (which together represent the core of the project’s technical innovation), creative content that appeals to underrepresented demographic groups, a Spanish-language curriculum version, and adaptive learning technology. Educators will have access to a Learning Management System, online classroom tools that are easy to implement both virtually and in-class, and an Administrative Dashboard for real-time school and school-district level reporting on student learning progress. The aims for this Phase II project are to show that the solution delivers the following learner benefits: (1) effective mastery of the fundamentals of genomics/genetics and personalized medicine, (2) effective understanding of the ethical and healthcare implications of genetics/genomics, (3) motivational impact on students, by promoting interest in genomics/STEM education and careers, (4) strong learning and motivational impact on underrepresented demographic groups. WestEd, will conduct To verify the attainment of these aims, the external research and evaluation partner, a Randomized Controlled Trial (with 750 9th grade students from classrooms with high populations of underserved students) on the fully developed educational solution. Aims 1-3 are supported if students in the treatment group show a pre- versus post-assessment performance improvement (measured in terms of information retention (Aim 1), attitudes towards the practical use of science (Aim 2), and interest in pursuing additional genomics/STEM education and a genomics/STEM career (Aim 3)) that is statistically larger than the improvements observed in the control group. Aim 4 is supported if performance in the treatment group is uncorrelated with demographic factors (i.e. males vs. females and minority vs. non-minority students). Overall, the engaging and inspirational learning solution proposed in this project will help better prepare tomorrow’s healthcare consumers and scientists and promote greater diversity in STEM education and practice.", "keywords": [ "3-Dimensional", "Achievement", "African American", "Attitude", "Behavior Therapy", "Behavioral Sciences", "Biomedical Research", "Breathing", "COVID-19 pandemic", "Case Study", "Chronic Disease", "Collaborations", "Control Groups", "Country", "Critical Thinking", "Demographic Factors", "Development", "Distance Learning", "E-learning", "Education", "Educational Curriculum", "Educational Intervention", "Elements", "Ensure", "Environment", "Ethics", "Evaluation", "Female", "Fibrinogen", "Future", "Genetic", "Genetic Diseases", "Genetic Enhancement", "Genetic Medicine", "Genetic Research", "Genome", "Genomics", "Goals", "Growth", "Health", "Healthcare", "High School Student", "Hispanic Americans", "Human", "Imagery", "Immersion", "Intervention", "Knowledge", "Language", "Learning", "Life", "Measures", "Minority", "Modernization", "Molecular Genetics", "Motivation", "National Institute of General Medical Sciences", "Native Americans", "Next Generation Science Standards", "Outcome", "Participant", "Performance", "Personal Satisfaction", "Phase", "Prevalence", "Prevention", "Randomized Controlled Trials", "Readiness", "Reporting", "Research", "STEM career", "Schools", "Science", "Science of genetics", "Science Technology Engineering and Mathematics Education", "Scientist", "Small Business Innovation Research Grant", "Societies", "Students", "System", "Technology", "The Jackson Laboratory", "Time", "Underserved Population", "Viral Genome", "Woman", "Work", "adaptive learning", "base", "bioinformatics tool", "career", "dashboard", "design", "digital", "experience", "genome sciences", "high school", "human disease", "improved", "innovation", "interactive tool", "interest", "junior high school", "learning ability", "literacy", "male", "next generation", "ninth grade", "online classroom", "pandemic disease", "personalized medicine", "prototype", "psychologic", "racial diversity", "racial minority", "role model", "school district", "skills", "student training", "teacher", "tool", "treatment group", "underserved students", "virtual", "virtual laboratory" ], "approved": true } }, { "type": "Grant", "id": "9516", "attributes": { "award_id": "2R44GM133222-02", "title": "\"Blueprint of Life\" Genomic Literacy Tool: An interactive to enhance genetic and genomic understanding with middle/high school students and their teachers through personal genetics and human disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-01", "end_date": "2023-04-30", "award_amount": 923813, "principal_investigator": { "id": 25223, "first_name": "Sally", "last_name": "Reidy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1840, "ror": "", "name": "D'VINCI INTERACTIVE, INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 25224, "first_name": "Mason Evan", "last_name": "Scuderi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1840, "ror": "", "name": "D'VINCI INTERACTIVE, INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The increasing prevalence of genetics and genomics information in modern life calls for an equally relevant and engaging solution to teach the next generation. Additionally, educational interventions that help close the participation and achievement gap of underrepresented demographic groups in STEM are sorely needed. In this NIGMS Phase II SBIR project, d’Vinci Interactive, in collaboration with The Jackson Laboratory, proposes to develop and evaluate a full-function prototype of the “Blueprint of Life” online educational solution, which is aimed at embedding genomics into middle school and high school classrooms. The solution will feature an expanded, NGSS-aligned supplemental curriculum that teaches key concepts around molecular genetics of personalized medicine, use of bioinformatics tools, the viral genome (particularly with regard to the COVID-19 pandemic), careers in genetics science, and the ethics of genetics research. The curriculum will be delivered via an online student learning portal designed to provide learning experiences that are engaging, inspirational, accessible, inclusive, and relevant to students’ lives, with features such as an immersive 3D/VR genome exploration module and an immersive Virtual Laboratory environment (which together represent the core of the project’s technical innovation), creative content that appeals to underrepresented demographic groups, a Spanish-language curriculum version, and adaptive learning technology. Educators will have access to a Learning Management System, online classroom tools that are easy to implement both virtually and in-class, and an Administrative Dashboard for real-time school and school-district level reporting on student learning progress. The aims for this Phase II project are to show that the solution delivers the following learner benefits: (1) effective mastery of the fundamentals of genomics/genetics and personalized medicine, (2) effective understanding of the ethical and healthcare implications of genetics/genomics, (3) motivational impact on students, by promoting interest in genomics/STEM education and careers, (4) strong learning and motivational impact on underrepresented demographic groups. WestEd, will conduct To verify the attainment of these aims, the external research and evaluation partner, a Randomized Controlled Trial (with 750 9th grade students from classrooms with high populations of underserved students) on the fully developed educational solution. Aims 1-3 are supported if students in the treatment group show a pre- versus post-assessment performance improvement (measured in terms of information retention (Aim 1), attitudes towards the practical use of science (Aim 2), and interest in pursuing additional genomics/STEM education and a genomics/STEM career (Aim 3)) that is statistically larger than the improvements observed in the control group. Aim 4 is supported if performance in the treatment group is uncorrelated with demographic factors (i.e. males vs. females and minority vs. non-minority students). Overall, the engaging and inspirational learning solution proposed in this project will help better prepare tomorrow’s healthcare consumers and scientists and promote greater diversity in STEM education and practice.", "keywords": [ "3-Dimensional", "Achievement", "African American", "Attitude", "Behavior Therapy", "Behavioral Sciences", "Biomedical Research", "Breathing", "COVID-19 pandemic", "Case Study", "Chronic Disease", "Collaborations", "Control Groups", "Country", "Critical Thinking", "Demographic Factors", "Development", "Distance Learning", "E-learning", "Education", "Educational Curriculum", "Educational Intervention", "Elements", "Ensure", "Environment", "Ethics", "Evaluation", "Female", "Fibrinogen", "Future", "Genetic", "Genetic Diseases", "Genetic Enhancement", "Genetic Medicine", "Genetic Research", "Genome", "Genomics", "Goals", "Growth", "Health", "Healthcare", "High School Student", "Hispanic Americans", "Human", "Imagery", "Immersion", "Intervention", "Knowledge", "Language", "Learning", "Life", "Measures", "Minority", "Modernization", "Molecular Genetics", "Motivation", "National Institute of General Medical Sciences", "Native Americans", "Next Generation Science Standards", "Outcome", "Participant", "Performance", "Personal Satisfaction", "Phase", "Prevalence", "Prevention", "Randomized Controlled Trials", "Readiness", "Reporting", "Research", "STEM career", "Schools", "Science", "Science of genetics", "Science Technology Engineering and Mathematics Education", "Scientist", "Small Business Innovation Research Grant", "Societies", "Students", "System", "Technology", "The Jackson Laboratory", "Time", "Underserved Population", "Viral Genome", "Woman", "Work", "adaptive learning", "base", "bioinformatics tool", "career", "dashboard", "design", "digital", "experience", "genome sciences", "high school", "human disease", "improved", "innovation", "interactive tool", "interest", "junior high school", "learning ability", "literacy", "male", "next generation", "ninth grade", "online classroom", "pandemic disease", "personalized medicine", "prototype", "psychologic", "racial diversity", "racial minority", "role model", "school district", "skills", "student training", "teacher", "tool", "treatment group", "underserved students", "virtual", "virtual laboratory" ], "approved": true } }, { "type": "Grant", "id": "10625", "attributes": { "award_id": "1R01HD110844-01", "title": "\"Chanjo Kwa Wakati\" - Leveraging community health workers and a responsive digital health system to improve vaccination coverage and timeliness in rural settings", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6227, "first_name": "Tracy", "last_name": "King", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-18", "end_date": "2027-08-31", "award_amount": 638030, "principal_investigator": { "id": 26669, "first_name": "Esther Stanslaus", "last_name": "Ngadaya", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 4149, "first_name": "Lavanya", "last_name": "Vasudevan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26670, "first_name": "Jan", "last_name": "Ostermann", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 930, "ror": "", "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Ensuring equitable vaccinations is critical for protecting all children against preventable and potentially dangerous infections such as polio, diphtheria, and measles. Yet, numerous studies have highlighted low vaccination coverage and timeliness, particularly among children from resource-limited settings. For example, in Tanzania, only 68% of children receive all basic vaccines that are recommended in the first year of life. Reasons for vaccination inequities are multifaceted; they include low caregiver knowledge about vaccines, and challenges with health service delivery and access. Health service interruptions during the global COVID-19 pandemic have further restricted opportunities for caregiver education, impacted vaccine access, and exacerbated vaccination inequities. Approaches that optimally utilize limited health workforce capacity and rapidly evolving digital health capacity for remote healthcare in resource-limited settings hold great potential for mitigating childhood vaccination inequities. We recently completed (1) a Fogarty-funded study (R21TW010262) that demonstrated the feasibility and efficacy of mobile phone-based reminders and conditional financial incentives for improving the coverage and timeliness of childhood vaccinations, and (2) a community health worker (CHW) intervention that was shown to be acceptable for mitigating caregiver knowledge gaps about childhood vaccines. Building on this prior work and with support from Tanzania’s National Immunization and Vaccine Development program, we propose to evaluate an integrated, community-based, digital intervention for promoting equity in childhood vaccinations. The outreach and educational intervention, called ”Chanjo Kwa Wakati” (“timely vaccination”), is targeted toward recent mothers and comprises a combination of CHW outreach and low-cost digital strategies (autonomous mobile phone-based vaccination promotion messages, reminders, stockout notifications, and incentive offers for timely vaccinations). In Aim 1, we will evaluate the effectiveness of Chanjo Kwa Wakati in promoting the coverage and timeliness of childhood vaccinations in a Type I effectiveness implementation hybrid trial. The trial will involve the staggered implementation of the intervention across catchment areas of 40 rural health facilities in two predominantly rural regions of Tanzania with large numbers of un- or under-vaccinated children. Vaccination outcomes will be analyzed for children born to 1200 women participating in the trial. In Aim 2, we will evaluate implementation factors associated with variations in intervention effectiveness, analyze the cost effectiveness of the intervention, and develop an implementation blueprint to guide scale-up to other settings. In Aim 3, we will evaluate the feasibility and potential efficacy of a machine learning approach for proactively identifying children at risk of non- or delayed vaccinations and validate predictive models using vaccination data gathered in Aim 1. Study findings will inform future implementations and scale up of Chanjo Kwa Wakati, including potential interventions to improve vaccination equity for children living in rural, resource- limited, or underserved communities in the United States.", "keywords": [ "1 year old", "Address", "Appointment", "Area", "COVID-19 pandemic", "Car Phone", "Caregivers", "Catchment Area", "Child", "Childhood", "Collaborations", "Communities", "Community Health Aides", "Country", "Dangerousness", "Data", "Diphtheria", "Discipline of Nursing", "Disease", "Educational Intervention", "Effectiveness", "Effectiveness of Interventions", "Elements", "Enrollment", "Ensure", "Evaluation", "Funding", "Goals", "Health Personnel", "Health Professional", "Health Services", "Health Technology", "Health behavior", "Health care facility", "Health system", "Immunization", "Incentives", "Income", "Infection", "Interruption", "Intervention", "Knowledge", "Life", "Machine Learning", "Measles", "Modeling", "Morbidity - disease rate", "Mothers", "National Institute of Nursing Research", "Notification", "Nurse&apos", "s Role", "Participant", "Performance", "Poliomyelitis", "Prevention", "Program Development", "Randomized", "Reach Effectiveness Adoption Implementation and Maintenance", "Research", "Research Design", "Research Priority", "Residual state", "Resource-limited setting", "Resources", "Risk", "Rural", "Rural Health", "Rural Population", "Side", "Speed", "System", "Tanzania", "Time", "Training", "Translational Research", "Underserved Population", "United States", "United States National Institutes of Health", "Vaccinated", "Vaccination", "Vaccines", "Variant", "Woman", "Work", "acceptability and feasibility", "base", "caregiver education", "cost", "cost effective", "cost effectiveness", "digital", "digital health", "digital intervention", "economic incentive", "effectiveness evaluation", "effectiveness implementation study", "effectiveness outcome", "financial incentive", "future implementation", "health care delivery", "health equity promotion", "implementation determinants", "implementation evaluation", "implementation intervention", "implementation outcomes", "improved", "innovation", "machine learning model", "mortality", "outreach", "predictive modeling", "prevent", "remote health care", "research to practice", "rural area", "rural setting", "scale up", "supervised learning", "tool", "underserved community", "urban area", "urban disparity", "vaccination outcome", "vaccination strategy", "vaccine access", "vaccine development" ], "approved": true } }, { "type": "Grant", "id": "5307", "attributes": { "award_id": "NNX08AP39G", "title": "\"COMET HOPPER\" Comet Hopper (CHopper) is a mission to explore the compositional and morphologic heterogeneity of a comet. Recent cometary flybys (Deep Impact at 9P/Tempel 1, Stardust at 81P/Wild 2, and Deep Space 1 at 19/P Borrelly) have revealed that the", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2008-05-15", "end_date": "2009-05-14", "award_amount": 0, "principal_investigator": { "id": 18653, "first_name": "JESSICA", "last_name": "SUNSHINE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1391, "ror": "", "name": "OFFICE OF RESEARCH ADMINISTRATION & ADVANCEMENT", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1391, "ror": "", "name": "OFFICE OF RESEARCH ADMINISTRATION & ADVANCEMENT", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "\"COMET HOPPER\" Comet Hopper (CHopper) is a mission to explore the compositional and morphologic heterogeneity of a comet. Recent cometary flybys (Deep Impact at 9P/Tempel 1, Stardust at 81P/Wild 2, and Deep Space 1 at 19/P Borrelly) have revealed that the", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11073", "attributes": { "award_id": "1R01AI175489-01", "title": "\"Extended dosing\" immunization to enhance humoral immunity to next-generation vaccines", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 10255, "first_name": "Joseph J.", "last_name": "Breen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-02-14", "end_date": "2028-01-31", "award_amount": 469443, "principal_investigator": { "id": 25134, "first_name": "Darrell J", "last_name": "Irvine", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The majority of licensed vaccines are thought to elicit protection mediated by humoral immunity. A key determinant of the specificity and affinity of the antibody response is the germinal center (GC) response elicited by immunization, wherein B cells enter GCs to undergo cyclic rounds of proliferation and somatic hypermutation to evolve higher-affinity antibodies, followed by exit from the GC to become long-lived plasma cells or memory B cells. Effective GC responses are thought to be critical for difficult pathogens such as HIV, and even for easily- neutralized viruses such as SARS-CoV-2, effective and long-lived GC responses are associated with more effective cross-neutralization of viral variants. Hence, optimizing GC responses is fundamental to vaccines broadly. In recent work, we have studied how vaccine kinetics– the temporal pattern of antigen and adjuvant exposure during immunization– impact humoral immunity and GC reaction in particular. Our preliminary studies have revealed that prolonged delivery of antigen to draining lymph nodes over a period of 2-3 weeks substantially alters the immune response. One particularly effective immunization approach, which we term “extended dosing” (ext-dosing) immunization, involves administering a given total dose of vaccine antigen and adjuvant as a half-dozen injections over two weeks in an escalating-dose pattern. Ext-dosing enhances the magnitude of the GC response in both small and large animal models and increases the clonality (number of distinct B cell clones participating in the GC), leading to enhanced neutralizing antibody production. These dramatic effects of ext-dosing vaccination warrant close study to understand how and why this strategy is so effective. As ext-dosing through repeat injections is not practical for human immunization, we are also highly motivated to develop alternate strategies to achieve the same immunologic effects without the need for 6 or more injections. To address these goals, our specific aims are (1) define how antigen exposure kinetics govern the immune response elicited by ext-dosing immunization, (2) determine how adjuvant exposure kinetics impact the immune response in ext-dosing, (3) test strategies to achieve “extended-dosing” effects using bolus subunit vaccine administration, and (4) to evaluate the potential for ext-dosing-like effects in mRNA vaccines. Altogether, these studies will both clarify fundamental concepts underlying effective primary immune responses and develop new translationally-relevant approaches to enhance immune responses elicited by subunit and mRNA vaccines. We test-bed these concepts using clinically-relevant antigens and adjuvants, and aim to pursue strategies we expect to be broadly applicable to vaccines independent of disease target.", "keywords": [ "2019-nCoV", "Address", "Adjuvant", "Animal Model", "Antibodies", "Antibody Affinity", "Antibody Formation", "Antibody Response", "Antigens", "Automobile Driving", "B-Lymphocytes", "Beds", "Binding", "Bolus Infusion", "Cells", "Clonality", "Clone Cells", "Collagen", "Complement", "Computer Analysis", "Computer Models", "Disease", "Dose", "Drug Kinetics", "Effectiveness", "Feedback", "Future Generations", "Generations", "Goals", "HIV", "Human", "Humoral Immunities", "Immune response", "Immunity", "Immunization", "Immunoglobulin Somatic Hypermutation", "Immunologics", "Inflammation", "Injections", "Kinetics", "Licensing", "Lymphocyte Activation", "Mediating", "Memory B-Lymphocyte", "Messenger RNA", "Modeling", "Output", "Pattern", "Periodicity", "Phenotype", "Plasma Cells", "Proliferating", "RNA", "RNA vaccine", "Reaction", "Regimen", "Replicon", "Role", "Specificity", "Structure of germinal center of lymph node", "Subunit Vaccines", "Testing", "Translating", "Vaccination", "Vaccine Adjuvant", "Vaccine Antigen", "Vaccines", "Variant", "Viral", "Virus", "Work", "cell type", "chemokine", "clinically relevant", "cytokine", "design", "draining lymph node", "in vivo", "neutralizing antibody", "novel vaccines", "pathogen", "response", "vaccine trial" ], "approved": true } }, { "type": "Grant", "id": "5079", "attributes": { "award_id": "3K08NS101084-05S1", "title": "\"HSV1-Induced NMDA Receptor Encephalitis: a De Novo Murine Model of Autoimmune Encephalitis\"", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 18141, "first_name": "WILLIAM PATRICK", "last_name": "Daley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-04-18", "end_date": "2022-12-31", "award_amount": 66728, "principal_investigator": { "id": 18142, "first_name": "JENNY J", "last_name": "LINNOILA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT: The goals of this Mentored Clinical Scientist Research Career Development Award (K08) are to A) obtain theoretical and hands-on training in 1) rodent magnetic resonance (MR) and positron emission tomography (PET) molecular imaging and 2) virology and immunology, B) apply this training towards developing a rodent model of viral-induced autoimmune encephalitis, and C) to use the resulting data to create a successful R01 application in the final years of this K08. This award will be a crucial stepping-stone towards my overall goal of developing into an independent autoimmune neurologist that sees patients and studies these diseases in the laboratory, contributing to earlier diagnoses and better treatments for these disabling disorders. Autoimmune encephalitis can be fatal and can lead to significant disability. It is difficult to gather enough patients with autoimmune encephalitis for clinical trials. There is a published rodent model of NMDA receptor (NMDAR) encephalitis. However, it relies on the adoptive transfer of human anti-NMDAR antibodies into the brains of mice. In order to study the pathogenesis of these disorders, it would be particularly important to develop an animal model of NMDAR encephalitis which does not rely on exogenous antibodies. It has been recently recognized in humans that some cases of NMDAR encephalitis are triggered by herpes simplex virus (HSV) encephalitis. Rodent models of HSV encephalitis are established. Preliminary work by our lab showed that some mice with HSV encephalitis make anti-NMDAR antibodies. This research proposal aims to demonstrate the pathogenicity of these antibodies and to use this model to better understand the patho- physiology of NMDAR encephalitis. This will be done by using targeted molecular imaging to understand the mechanisms as well as profiling the immune responses involved in this autoimmune neurologic disorder. I am a board-certified Harvard-trained neurologist with specific clinical fellowship training in autoimmune neurology through the Mayo Clinic. I have obtained the top clinical training available in this field. Furthermore, I have gained additional experience in basic research within this topic by spending time in the laboratory of the renowned autoimmune neurologist Dr. Josep Dalmau, one of my co-mentors on this project. I bring a solid grounding in molecular biology, gained through my Ph.D. studies. In addition, I have a strong publication and funding record. The research career development plan outlined within this proposal will equip me with a better understanding of virology and immunology and the latest methodologies within these fields that can be applied to uncover the pathophysiology of parainfectious autoimmune neurologic disorders. The research environment across the MGH, Harvard, and MIT campuses is outstanding and my mentors have the relevant and necessary expertise to guide this career development plan. I am a full time faculty member in the Massachusetts General Hospital (MGH) Department of Neurology and an Instructor in Neurology at Harvard Medical School. I have the full backing of the chair of my department, Dr. Cudkowicz, to develop into an independent researcher.", "keywords": [ "Adoptive Transfer", "Animal Model", "Antibodies", "Autoimmune", "Autoimmune encephalitis", "Award", "Back", "Basic Science", "Brain", "Clinic", "Clinical", "Clinical Trials", "Data", "Development Plans", "Disease", "Doctor of Philosophy", "Early Diagnosis", "Early treatment", "Encephalitis", "Environment", "Faculty", "Fc Receptor", "Fellowship", "Functional disorder", "Funding", "General Hospitals", "Goals", "Herpes encephalitis", "Herpesvirus 1", "Hospital Departments", "Human", "Immune response", "Immunology", "K-Series Research Career Programs", "Laboratories", "Lead", "Magnetic Resonance", "Massachusetts", "Mentors", "Methodology", "Modeling", "Molecular Biology", "Molecular Target", "Mus", "N-Methyl-D-Aspartate Receptors", "Neurologist", "Neurology", "Pathogenesis", "Pathogenicity", "Patient-Focused Outcomes", "Patients", "Positron-Emission Tomography", "Publications", "Publishing", "Research", "Research Personnel", "Research Proposals", "Rodent", "Rodent Model", "Scientist", "Solid", "Time", "Training", "Viral", "Work", "career development", "disability", "experience", "improved", "instructor", "medical schools", "member", "molecular imaging", "mouse model", "nervous system disorder", "novel", "targeted biomarker", "targeted imaging", "virology" ], "approved": true } }, { "type": "Grant", "id": "7988", "attributes": { "award_id": "1R15GM146194-01", "title": "\"Investigation of Membrane Fusion Interactions of Enveloped Viruses using Magnetically-Labeled Liposomes\"", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22244, "first_name": "MICHAEL", "last_name": "SAKALIAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-06-01", "end_date": "2025-05-31", "award_amount": 369655, "principal_investigator": { "id": 23889, "first_name": "Santimukul", "last_name": "Santra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1656, "ror": "https://ror.org/04hteea03", "name": "Pittsburg State University", "address": "", "city": "", "state": "KS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1656, "ror": "https://ror.org/04hteea03", "name": "Pittsburg State University", "address": "", "city": "", "state": "KS", "zip": "", "country": "United States", "approved": true }, "abstract": "Program Director/Principal Investigator: Santra, Santimukul PROJECT SUMMARY/ABSTRACT This application proposes to develop liposome-coated iron oxide nanosensors (LIONs) mimicking as magnetically-labeled host membranes to detect fusion interactions of enveloped viruses. Spin-spin T2 relaxation technique will be established as a generic bioanalytical method to detect dynamic conformational changes in viral glycoproteins that play vital roles in fusion interactions. Within the first aim, influenza fusion protein interactions with LIONs membrane will be studied, considering diverse fusion triggering environmental factors including low pH, protease activation and receptor binding. Further studies to investigate the sensitivity of this LIONs technology in quantifying similar fusion interactions with more native configurations of HA is demonstrated using virus-like particle (VLPs) and shorter domains derived from HA. Similarly, fusion experiments will be carried out using ganglioside-conjugated LIONs. The promising outcome of this research will be screening potential antiviral candidates including small molecules and neutralizing antibodies. The second aim establishes the broad adaptability of this sensitive LIONs technology for evaluation of fusion interactions of enveloped viruses where presence of membrane receptor is an important trigger, for example, SARS-CoV-2. Receptor-conjugated LIONs (R-LIONs) will be developed for the elucidation of this vital process using spike proteins and reporter virus particles (RVPs) of SARS-CoV-2. R-LIONs offers a novel approach of exploring the role of variety of entry receptors that may play an important role in SARS-CoV-2 membrane fusion. The third aim of this proposal determines further advantage of nanosensor technology for the real-time monitoring of virus-mediated cell fusion. SARS-CoV-2 virus entry into ACE2 receptor overexpressing mammalian cells (HEK-293T) will be examined by developing magnetically labeled reporter virus particles (M-RVPs). Parallel experiments will be carried out in the presence of fusion inhibitors and neutralizing antibodies. The important application of this experiment will be demonstrated by screening potential new fusion inhibitors and antiviral candidates. The proposed AREA proposal, if successful, will develop novel nanosensor technology for the rapid detection of fusion interactions of enveloped viruses including SARS-CoV-2 and influenza. This adaptable technology will allow for rapid screening of potential drug candidates and fusion inhibitors of many other enveloped viruses, in a timely fashion. Most importantly, this AREA proposal will initiate the proposed PURE program for undergraduate education, and increase the hands-on biomedical research opportunity and learning for students in our undergraduate-focused institution. OMB No. 0925-0001 and 0925-0002 (Rev. 03/20 Approved Through 02/28/2023) Page Project Summary", "keywords": [ "2019-nCoV", "ACE2", "Affinity", "Antiviral Agents", "Biological", "Biological Assay", "Biomedical Research", "Cell Line", "Cell fusion", "Cell membrane", "Cells", "Characteristics", "Chimeric Proteins", "Coupling", "Data", "Data Analyses", "Development", "Disease Outbreaks", "Dyes", "Ebola", "Environmental Risk Factor", "Evaluation", "Fluorescence", "Ganglioside GM1", "Gangliosides", "Glycoproteins", "Goals", "Hemagglutinin", "Image Analysis", "Infection", "Influenza", "Institution", "Investigation", "Label", "Learning", "Lipids", "Liposomes", "Luciferases", "Magnetism", "Mammalian Cell", "Measurement", "Measures", "Mediating", "Membrane", "Membrane Fusion", "Membrane Lipids", "Methods", "Modeling", "Molecular Conformation", "Outcomes Research", "Pathogen detection", "Pathogenicity", "Peptide Hydrolases", "Phase", "Play", "Principal Investigator", "Process", "Property", "Proteins", "Rapid screening", "Reaction", "Recombinants", "Relaxation", "Relaxation Techniques", "Reporter", "Reporting", "Reproducibility", "Role", "Screening procedure", "Sialic Acids", "Signal Transduction", "Students", "Technology", "Temperature", "Testing", "Time", "Trypsin", "Validation", "Viral", "Viral Fusion Proteins", "Viral Pathogenesis", "Viral Proteins", "Virion", "Virus", "Virus-like particle", "Work", "ZIKA", "analytical method", "base", "drug candidate", "experimental study", "high throughput technology", "influenzavirus", "inhibitor/antagonist", "insight", "instrument", "iron oxide", "metal chelator", "nanosensors", "neutralizing antibody", "new technology", "novel", "novel strategies", "overexpression", "pandemic disease", "programs", "rapid detection", "real time monitoring", "receptor", "receptor binding", "screening", "single molecule", "small molecule", "temporal measurement", "time use", "tool", "undergraduate education", "undergraduate student", "virus envelope" ], "approved": true } }, { "type": "Grant", "id": "5384", "attributes": { "award_id": "0730080", "title": "\"Magnetic Excitations in Semiconductors: Bridges to the next Decade\" -- Symposium and Public Lecture; Buffalo, NY; March 7-8, 2008", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "MATERIALS CENTERS & EDUCATION" ], "program_reference_codes": [], "program_officials": [ { "id": 18857, "first_name": "Maija", "last_name": "Kukla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2007-08-01", "end_date": "2008-07-31", "award_amount": 9000, "principal_investigator": { "id": 18859, "first_name": "Bernard", "last_name": "Weinstein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 422, "ror": "", "name": "SUNY at Buffalo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18858, "first_name": "Alexander N", "last_name": "Cartwright", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 422, "ror": "", "name": "SUNY at Buffalo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The proposed project is to support the Symposium, \"Magnetic Excitations in Semiconductors: Bridges to the Next Decade\", which will bring together many of the world leaders and the active young investigators in its subject area. It is designed both to highlight key advances in the field of magnetic excitations in semiconductors (MES), and to provide links to new long-term directions for research. It is planned for March 7-8, 2008 at the University of Buffalo, and will also honor the research of Dr. B. D. McCombe whose work has helped to shape the understanding of MES. An eminent group of 19 scholars, including two Nobel laureates, have agreed to give plenary lectures. Additional contributions in 13 topic-areas, chosen for their impact on the science and technology of MES, will be given in poster format. The Symposium will seek to maximize the intellectual exchange between young investigators and established leaders. The resulting increase in science knowledge-base, stimulation of new research technology, and wide dissemination of ideas to scientists specializing in the field, are the main intellectual merit of the proposed project.\nThe Symposium will also feature the public lecture \"Putting Spin into Electronics\" as part of its program, in order to promote informal outreach learning in an area of MES that has strong potential to impact society. This lecture will be presented by Dr. Igor Zutic (University of Buffalo Physics), who is a leading theorist in the field of Spintronics and a highly engaging speaker. Dr. Zutic's lecture will be geared to non-scientists, and will be free and open to the public. It will be widely promoted at local schools and in the media, and held in a large venue hall at the University of Buffalo. This outreach lecture will be included along with the Symposium's plenary and poster presentations in a Web-Proceedings that is made fully available to the general public. World wide searchable access to the Proceedings by means of any OAI compliant metasearch engines or major directories (e.g., Google Scholar, OpenDOAR) will be set up under the SUNY Institutional Repository. The educational outreach fostered by the Symposium's public lecture and open dissemination in areas important to the non-scientific public constitute the broader impacts of this project.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5878", "attributes": { "award_id": "3K43TW011418-03S1", "title": "\"Plasma and cellular immune biomarkers of Kaposi's sarcoma in HIV-1 suppressed patients\"", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 20126, "first_name": "GEETHA PARTHASARATHY", "last_name": "Bansal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-08-01", "end_date": "2024-04-30", "award_amount": 80371, "principal_investigator": { "id": 20127, "first_name": "Salum Juma", "last_name": "Lidenge", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1164, "ror": "", "name": "MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS", "address": "", "city": "", "state": "", "zip": "", "country": "TANZANIA U REP", "approved": true }, "abstract": "Despite more than a decade of widespread antiretroviral therapy (ART) implementation, Kaposi’s sarcoma (KS) remains the most common malignancy in people living with HIV-1/AIDS, in whom it causes significant morbidity and mortality [1]. Beyond a requirement for KSHV infection, the mechanisms underlying KS development are poorly understood. KS prevalence is high in people living with HIV-1 where it associates with CD4+ T-cell depletion. Thus, CD4+ T-cell functional dysregulation has been suggested to lead to KS development. Indeed, following successful ART, there is reconstitution of CD4+ T-cells [17] which often leads to KS resolution. In contrast, KS in patients with high CD4+ T-cells and low HIV-1 PVL [4–7] have been described, suggesting immune defects beyond CD4 T-cell reconstitution. In HIV-1 PVL suppressed patients, it is possible that there exist quantitative or qualitative differences in CD4+ T-cells between patients that develop KS and those who remain asymptomatic. These differences might limit the ability of CD4+ T-cells to provide help to B-cells and cytotoxic CD8+ T-cell. Alternatively, CD4+ T-cells might be fully functional in HIV-1 PVL suppressed patients but the defect is in the cytotoxic CD8+ T-cell compartment in those with KS. Chronic antigenic stimulation could induce CD8+ T-cells to states of exhaustion or anergy making them non-responsive to KSHV infected cells and KS tumors. Importantly, there are no biomarkers of KS control or its absence that can be used to identify individuals that are high risk for KS despite HIV-1 control. Our group and others have shown dysregulation of metabolic pathways in KS tumors [11–14]. Since altered metabolites often correlate with disease, identification of plasma and or urine metabolites that differentiate HIV-suppressed patients with and without KS could prove to be important KS biomarkers. Therefore, the objective of this proposal is to recruit Tanzanian HIV-1 PVL suppressed patients presenting with KS at ORCI, and age and sex-matched co- infected but asymptomatic controls from nearby CTCs in order to define immune responses and metabolomic profiles that differentiate the two groups. The hypothesis is that, distinct metabolomic and immune responses differentiate reconstituted HIV-1 suppressed patients experiencing KS from otherwise matched asymptomatic controls. Transcriptional profiling of relevant immune cell subsets and metabolomics/proteomic analysis of plasma and urine will provide mechanistic insight into the bases for the differential metabolomics/proteomics and immune responses. Therefore, the proposed study has potential to identify biomarkers for KS diagnostics, treatment management, or to identify potential immunotherapeutic or vaccine development strategies.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Address", "Africa South of the Sahara", "Age", "B-Lymphocytes", "Biological Markers", "CD4 Positive T Lymphocytes", "CD8-Positive T-Lymphocytes", "Caring", "Cell Compartmentation", "Cell Count", "Cell Differentiation process", "Cells", "Chronic", "Clinical Management", "Defect", "Development", "Diagnostic", "Disease", "Early Diagnosis", "Gene Expression Profiling", "HIV", "HIV-1", "Human Herpesvirus 8", "Immune", "Immune response", "Immune system", "Immunologic Markers", "Immunologics", "Immunophenotyping", "Immunotherapeutic agent", "Immunotherapy", "Individual", "Infection", "Institutes", "Kaposi Sarcoma", "Lead", "Link", "Malignant Neoplasms", "Mediating", "Metabolic Pathway", "Morbidity - disease rate", "Oceans", "Patients", "Pattern", "Plasma", "Prevalence", "Proteome", "Proteomics", "Recovery", "Reporting", "Resolution", "Role", "T cell reconstitution", "T cell response", "T-Cell Depletion", "T-Lymphocyte", "Tanzania", "Treatment Efficacy", "Urine", "Viral", "Viral Load result", "anergy", "antiretroviral therapy", "base", "cell mediated immune response", "chemotherapy", "co-infection", "comparative", "cytokine", "cytotoxic CD8 T cells", "early detection biomarkers", "enzyme linked immunospot assay", "exhaustion", "experience", "high risk", "immune reconstitution", "insight", "metabolome", "metabolomics", "mortality", "potential biomarker", "reconstitution", "recruit", "response", "sex", "transcriptome", "transcriptome sequencing", "transcriptomics", "treatment center", "tumor", "vaccine development", "virology" ], "approved": true } } ], "meta": { "pagination": { "page": 1, "pages": 1392, "count": 13920 } } }