Grant List
Represents Grant table in the DB
GET /v1/grants?sort=-id
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-id", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=-id", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=2&sort=-id", "prev": null }, "data": [ { "type": "Grant", "id": "15943", "attributes": { "award_id": "1R13OD039737-01", "title": "Annual Symposium on Nonhuman Primates", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 44387, "first_name": "SIGE", "last_name": "ZOU", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-05-01", "end_date": "2028-04-30", "award_amount": 74999, "principal_investigator": { "id": 8251, "first_name": "Deborah H.", "last_name": "Fuller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44388, "first_name": "Jon E", "last_name": "Levine", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44389, "first_name": "Corinna Nicole", "last_name": "Ross", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 799, "ror": "", "name": "UNIVERSITY OF WISCONSIN-MADISON", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "With this R13 application, we request funding to support, in part, the costs for planning, publicizing, and hosting the 42nd, 43rd, and 44th Annual Symposia on Nonhuman Primate Models for AIDS. For more than four decades, this symposium has served as the premier scientific forum for the exchange of information, including new research findings and scientific perspectives, among HIV/AIDS investigators whose research includes studies in nonhuman primates (NHPs). Disseminating the latest research findings in NHP models of AIDS while also facilitating discussion and exchange of information between basic scientists and clinicians remains a priority, as do focusing on emerging technologies to accelerate translation of NHP studies into the clinic and engaging a broader and more diverse group of researchers in HIV/AIDS research in NHP models. This meeting, the only one of its kind in the world, convenes an international group of scientists whose research focuses on the study of natural and experimental immunodeficiency virus infections in NHPs, as well as on the development of novel therapeutics, prophylactic vaccines for HIV, and curative approaches. Emerging topics in related infectious diseases (such as COVID-19 pathogenesis, vaccines and treatment) may also be included. The seven National Primate Research Centers (NPRCs) host this meeting in rotation, and upcoming symposia hosts will be the Wisconsin (2025), Southwest (2026), and Washington (2027) NPRCs. We plan a hybrid format with most participants attending in person and others joining online to access oral and poster sessions. The conference will begin on day 1 with registration, a keynote address by a leading HIV/AIDS researcher, and an evening reception. The following two and a half days will include scientific presentations from invited speakers and accepted oral abstracts. Each symposium scientific committee will select session topics and speakers to highlight new and cutting-edge technologies in their respective fields. Each session will open with a 30-minute talk by an invited chair. Individuals whose abstracts are accepted for oral presentations will give the remaining session talks. A poster session will occur on the evening of day 2, and there will be a banquet on the evening of day 3. As is traditional for this symposium, the Journal of Medical Primatology will publish all poster and oral abstracts in a special issue. In partnership with the HIV Vaccine Trials Network (HVTN), the NHP AIDS Symposium will also host a pre-symposium meeting for early-stage investigators (ESI). This meeting will be open to the attendees of a linked ESI Conference the HVTN sponsors. ESI attendees and mentors will focus on grant writing, budgeting, and networking, and will participate in a Q&A with NIH Program Officers. We believe bringing together researchers from a variety of diverse backgrounds will generate future collaborations and scientific advances. Knowledge shared and gained at upcoming Annual Nonhuman Primate Models for AIDS Symposia will further the continued, effective use of NHP models to maintain long term control of HIV replication in the absence of antiretroviral therapy and to design interventions to prevent or eradicate HIV infection.", "keywords": [ "2019-nCoV", "AIDS Vaccines", "Acceleration", "Acquired Immunodeficiency Syndrome", "Address", "Applications Grants", "Budgets", "COVID-19 pathogenesis", "COVID-19 treatment", "COVID-19 vaccine", "Clinic", "Collaborations", "Communicable Diseases", "Development", "Disease", "Drug Delivery Systems", "Emerging Technologies", "Epidemic", "Fees", "Fostering", "Funding", "Future", "Generations", "Grant", "HIV", "HIV Infections", "HIV Vaccine Trials Network", "HIV vaccine", "HIV/AIDS", "Health", "Human", "Hybrids", "Immune response", "Immunologist", "Individual", "International", "Intervention", "Journals", "Knowledge", "Life", "Link", "Logistics", "Medical", "Mentors", "Mission", "Monkeypox", "Oral", "Participant", "Pathogenesis", "Persons", "Preventive vaccine", "Primates", "Publishing", "Research", "Research Personnel", "Resources", "Rotation", "SIV", "Scientific Advances and Accomplishments", "Scientist", "Technology", "Testing", "Translations", "United States National Institutes of Health", "Universities", "Viral reservoir", "Virus", "Virus Diseases", "Washington", "Wisconsin", "Writing", "Zika Virus", "Zoonoses", "antiretroviral therapy", "cost", "disability", "emerging virus", "experience", "falls", "global health", "immunodeficiency", "innovation", "meetings", "neutralizing antibody", "nonhuman primate", "nonhuman primate models", "novel therapeutics", "novel vaccines", "originality", "pandemic virus", "posters", "prevent", "programs", "response", "symposium", "therapy design", "tool" ], "approved": true } }, { "type": "Grant", "id": "15942", "attributes": { "award_id": "3U19AI089674-16S1", "title": "Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44386, "first_name": "MALLA R", "last_name": "RAO", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-05-01", "end_date": "2029-04-30", "award_amount": 590328, "principal_investigator": { "id": 11159, "first_name": "MATTHEW G", "last_name": "DORSEY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1116, "ror": "https://ror.org/03dmz0111", "name": "Makerere University", "address": "", "city": "", "state": "", "zip": "", "country": "UGANDA", "approved": true } ] }, "other_investigators": [ { "id": 11138, "first_name": "MOSES Robert", "last_name": "KAMYA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1116, "ror": "https://ror.org/03dmz0111", "name": "Makerere University", "address": "", "city": "", "state": "", "zip": "", "country": "UGANDA", "approved": true } ] } ], "awardee_organization": { "id": 2635, "ror": "", "name": "UNIVERSITY OF CALIFORNIA, SAN FRANCISCO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Summary/Abstract Malaria remains one of the most important global health challenges, with an estimated 247 million cases and 619,000 deaths in 2021, of which 95% of cases and 96% of deaths were in the WHO Africa region. The scale up of proven control interventions resulted in significant reductions in the burden of malaria following the turn of the century. However, since 2015 progress has stalled and even reversed course in some of the highest burden countries of Africa. Indeed, a myriad of challenges, including the spread of insecticide resistance, changes in vector composition and behavior, the emergence of artemisinin partial resistance, and the COVID- 19 pandemic have created a precarious situation. Our program called “PRISM” has been based in Uganda, representing the East African region for the International Centers of Excellence for Malaria Research network. Uganda is emblematic of the challenges faced by high burden countries, where routine surveillance systems are inadequate to assess trends in the burden of malaria or to monitor the impact of control interventions. Through PRISM we have implemented a comprehensive malaria surveillance program including enhanced health facility-based surveillance and detailed longitudinal studies. Complementary laboratory-based studies include surveillance for markers of antimalarial drug and insecticide resistance and serologic measures of malaria exposure. These studies have greatly improved our understanding of the epidemiology of malaria in Uganda and of the impact of control interventions. In this renewal application we propose to continue key components of our health facility and community-based malaria surveillance to strategically focus on quantifying the impact of malaria control interventions, working in close collaboration with our partners at the Uganda National Malaria Control Division (NMCD). We will utilize specimens collected from our surveillance system to generate genomic and serologic data to address key questions about malaria epidemiology, transmission, diagnostics, and antimalarial drug and insecticide resistance. The central theme of our program will be to improve malaria surveillance to better assess the impact of malaria control interventions and guide evidence-based utilization of existing and novel interventions to reduce the malaria burden using an adaptive approach. The program will consist of three research projects linked together in an integrated manner to maximize scientific discovery. Research Project 1 (Surveillance and Impact Evaluation Project) will utilize health facility and community-based malaria surveillance data from sites with varied transmission intensity and control interventions to monitor trends, estimate the impact of interventions, and provide clinical data and specimens for our other research projects. Research Project 2 (Resistance Project) we will characterize the evolution of genotypic markers of drug and insecticide resistance and assess the impacts of resistance on malaria transmission. Research Project 3 (Molecular Epidemiology Project) will characterize key parasite and vector genomic traits and human serological responses.", "keywords": [ "Acceleration", "Address", "Africa", "Anti-malarial drug resistance", "Artemisinins", "Beds", "Behavior", "Behavioral", "Biological Assay", "COVID-19 pandemic", "Cessation of life", "Child", "Clinical Data", "Collaborations", "Communities", "Community Surveys", "Country", "Culicidae", "Data", "Diagnostic", "Drug resistance", "East African", "Epidemiology", "Evolution", "Formulation", "Funding Mechanisms", "Future", "Genomics", "Genotype", "Health Care Facility", "Household", "Human", "Immunology", "Impact evaluation", "Insecticide Resistance", "Insecticides", "Intervention", "Knowledge", "Laboratories", "Link", "Longitudinal Studies", "Malaria", "Measures", "Mediating", "Membrane", "Microscopic", "Modeling", "Molecular", "Molecular Epidemiology", "Monitor", "Mutation", "Parasitemia", "Parasites", "Patients", "Policies", "Research", "Research Project Grants", "Residual state", "Resistance", "Resources", "Risk", "Rotation", "Sampling", "School-Age Population", "Serology", "Site", "Specimen", "Surveillance Program", "System", "Target Populations", "Time", "Uganda", "Work", "asexual", "detection assay", "evidence base", "feeding", "global health", "improved", "international center", "malaria transmission", "member", "multiple data sources", "novel", "programs", "pyrethroid", "response", "sample collection", "scale up", "surveillance data", "tool", "trait", "transmission process", "trend", "vector" ], "approved": true } }, { "type": "Grant", "id": "15941", "attributes": { "award_id": "3U01AI069911-20S5", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 195343, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15940", "attributes": { "award_id": "3U01AI069911-20S4", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 747173, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15939", "attributes": { "award_id": "3U01AI069911-20S2", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 121192, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15938", "attributes": { "award_id": "3U01AI069911-20S3", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 276896, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15937", "attributes": { "award_id": "3U01AI069911-20S6", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 47470, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15936", "attributes": { "award_id": "3U01AI069911-20S1", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 317911, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15935", "attributes": { "award_id": "1K99AG086538-01A1", "title": "Molecular profiles for mortality risk and longevity: a multiomics approach", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 44380, "first_name": "CHRISTY", "last_name": "CARTER", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-16", "end_date": "2027-03-31", "award_amount": 122858, "principal_investigator": { "id": 44381, "first_name": "Fenglei", "last_name": "Wang", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 3374, "ror": "", "name": "HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The US life expectancy experienced a generally upward trend over the past few decades; however, in recent years, it has seen a decline. This decline cannot be solely attributed to the excess mortality caused by COVID- 19 but also to an increased death rate from other leading causes (e.g., heart disease, cancer, and stroke). The biological mechanisms that underlie aging process and mortality in humans are multifactorial and remain poorly understood. Although multiple genetic variants have been linked to lifespan in model organisms, many of these genes do not exhibit significant variation in human populations. The heritability of human lifespan also appears to be relatively low. One possible explanation for lack of significant loci and low heritability is the complexity of survival as a phenotype, which involves multiple biological processes, environmental influences, and chance. The stochastic component of survival may dilute the genetic influence on the time-to-death phenotype. Consequently, a substantial mechanistic gap exists between genotype and mortality. The proposed K99/R00 project aims to utilize plasma metabolomic and proteomics profile to bridge this gap and comprehensively investigate the relationship between genes, proteins, metabolites, and mortality risk. To achieve this goal, Dr. Fenglei Wang will incorporate data from multiple sources, including the Nurses’ Health Study (NSH), NHSII, Health Professionals Follow-up Study (HPFS), Hispanic Community Health Study/Study of Latinos (HCHS/ SOL), VITamin D Omega3 TriAL (VITAL), UK Biobank (UKB), and eQTLGen. In Aim 1 (K99), Dr. Wang will determine genetic factors that influence a plasma metabolomic signature, previously developed by him, which has the potential to predict all-cause mortality. He will also evaluate the causal relationship between the metabolomic signature and four diseases that are major causes of death. In Aim 2 (R00), Dr. Wang will construct a plasma proteomic signature capable of predicting all-cause mortality and identify genetic factors influencing the proteomic signature. Then he will compare the influential genetic factors identified for the proteomic signature to those for the metabolomic signature. In Aim 3 (R00), Dr. Wang will conduct plasma proteomic profiling in a nested case-control study to examine the relationship between longitudinal changes in plasma metabolomic and proteomic profiles and healthy longevity. Findings from this project may improve our understanding of the molecular profiles associated with the aging process and mortality, and inform potential interventions for improving health outcomes and extending human lifespan. Dr. Wang has assembled a strong mentoring team to provide expertise in aging research and training in genetics, proteomics, and multi-omics integration. The new skills will complement his current expertise in nutritional epidemiology and metabolomic research. His outlined training plan will provide the necessary knowledge and skills for Dr. Wang to advance towards his career goal of becoming an independent researcher who specializes in the application of multi-omics approach to study nutrition and healthy aging.", "keywords": [ "Affect", "Age", "Aging", "Biological", "Biological Process", "COVID-19", "COVID-19 mortality", "Cardiovascular Diseases", "Cause of Death", "Cessation of life", "Chronic Disease", "Colorectal Cancer", "Complement", "Coronary heart disease", "Data", "Data Set", "Databases", "Death Rate", "Diet", "Dietary Factors", "Disease", "Etiology", "Excess Mortality", "Follow-Up Studies", "Future", "Gene Expression", "Genes", "Genetic", "Genomics", "Genotype", "Goals", "Health", "Health Professional", "Heart Diseases", "Heritability", "Hispanic Community Health Study/Study of Latinos", "Human", "Influentials", "Intervention", "Investigation", "Knowledge", "Life Expectancy", "Link", "Longevity", "Malignant Neoplasms", "Mendelian randomization", "Mentors", "Molecular", "Molecular Profiling", "Multiomic Data", "National Institute on Aging", "Nested Case-Control Study", "Non-Insulin-Dependent Diabetes Mellitus", "Nurses' Health Study", "Nutrition", "Omega-3 Fatty Acids", "Outcome", "Participant", "Pattern", "Phenotype", "Pilot Projects", "Plasma", "Population", "Population Study", "Prospective cohort study", "Proteins", "Proteome", "Proteomics", "Publishing", "Recommendation", "Research", "Research Personnel", "Risk", "Stroke", "Technology", "Time", "Training", "Variant", "Vitamin D", "Work", "aging process", "aging related", "biobank", "career", "endophenotype", "experience", "genetic variant", "genome wide association study", "genome-wide", "healthy aging", "improved", "life span", "lifestyle factors", "machine learning model", "metabolomics", "model organism", "molecular marker", "mortality", "mortality risk", "multiple data sources", "multiple omics", "nutritional epidemiology", "prospective", "proteomic signature", "skills", "statistics", "transcriptome", "trend" ], "approved": true } }, { "type": "Grant", "id": "15934", "attributes": { "award_id": "1R13EB037429-01", "title": "International Symposium on Medical Robotics", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 44349, "first_name": "DAVID JOSEPH", "last_name": "GUTEKUNST", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2028-05-31", "award_amount": 10000, "principal_investigator": { "id": 44379, "first_name": "Jun", "last_name": "Sheng", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1190, "ror": "", "name": "UNIVERSITY OF CALIFORNIA RIVERSIDE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. SUMMARY Significance, timeliness and rationale. NIBIB’s mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the unique combination of flexibility and confining ability of cell membranes which is possible because lipids cooperatively aggregate into a lamellar LC phase in water. Many viruses, e.g., SARS-CoV-2, are enveloped in a lipid membrane and they may employ LC order for packing their nucleic acid cargo. Non-biological LCs have turned out to be sensitive in detecting and reporting on the presence of pathogens and toxins, making them highly interesting for autonomous bio-/chemosensors. LC formation is thus an integral component of what keeps us healthy, and they are emerging as a powerful tool for detecting disease agents. Although this connection is long known, it has until now been researched only marginally, constituting an under-explored opportunity in addressing societal needs. Today, the international LC research community is undergoing a rebirth, fully embracing these aspects. Interdisciplinary crossovers where LC science meets biological, life and pharmaceutical sciences, and engineering and materials science, play a groundbreaking role in leveraging the opportunities. Additional impact on the core fields of the NIH-NIBIB mission comes from, e.g., the exploration of LC elastomers in soft actuators or implants in the human body. Objective. Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) in Liquid Crystals, 2025: “Uniting disciplines for global challenges: Liquid crystals as active and learning materials” to take place July 6-11th 2025 (GRS July 5-6, 2025) at the Southern New Hampshire University, Manchester, NH, US. The joint meetings will bring together US and international researchers at the forefront of today’s vibrant LC science, spanning its full breadth and connecting academia, industry and military labs, early career and established researchers, and harnessing every opportunity to promote scientific discussions and encourage collaboration between speakers, discussing leaders and participants. Approach. 23 prominent speakers have confirmed our invitations to present unpublished cutting-edge research. Our goal is to promote the participation of students, postdocs, and scholars at an early stage of their careers. We seek to promote scientific discussion among all participants who will fuel the future of Liquid Crystal Science in biomedical and biotechnology applications. Academic speakers are complemented by 2 industry and 2 military research lab speakers. Additionally, 5 speaker slots will be given to outstanding scientists selected from submitted poster abstracts. To further strengthen the voice of young researchers, the GRC is preceded by the GRS, catering only to students and post-docs and providing mentoring and career advice. During the GRC, young scientists will be given priority in all scientific discussions.", "keywords": [ "2019-nCoV", "Academia", "Address", "Applied Research", "Area", "Augmented Reality", "Basic Science", "Biological", "Biotechnology", "Birth", "Caring", "Cell membrane", "Collaborations", "Communities", "Complement 2", "Detection", "Diagnosis", "Discipline", "Disease", "Drug Delivery Systems", "Elastomers", "Engineering", "Environment", "Faculty", "Fostering", "Future", "Goals", "Health Status", "Human body", "Implant", "Industry", "International", "Joints", "Leadership", "Life", "Lipids", "Liquid substance", "Medical", "Membrane Lipids", "Mentors", "Military Personnel", "Mission", "Monitor", "National Institute of Biomedical Imaging and Bioengineering", "New Hampshire", "Nucleic Acids", "Oral", "Participant", "Pharmacologic Substance", "Phase", "Play", "Postdoctoral Fellow", "Prevention", "Public Health", "Recommendation", "Recording of previous events", "Reporting", "Research", "Research Personnel", "Robotics", "Role", "Science", "Scientist", "Students", "Text", "Therapeutic", "Toxin", "United States National Institutes of Health", "Universities", "Virus", "Voice", "Water", "career", "elastomeric", "fascinate", "flexibility", "frontier", "learning materials", "liquid crystal", "materials science", "meetings", "pathogen", "peer", "posters", "sensor", "social", "student participation", "symposium", "tool" ], "approved": true } } ], "meta": { "pagination": { "page": 1, "pages": 1419, "count": 14184 } } }