Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=5&sort=funder
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=funder", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=funder", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=6&sort=funder", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=funder" }, "data": [ { "type": "Grant", "id": "3309", "attributes": { "award_id": "1808239", "title": "Understanding Surface-Mediated Hyperpolarization of Water and other Neat Liquids from Parahydrogen", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "Chemical Measurement & Imaging" ], "program_reference_codes": [], "program_officials": [ { "id": 10478, "first_name": "Kelsey", "last_name": "Cook", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-08-01", "end_date": "2021-07-31", "award_amount": 470000, "principal_investigator": { "id": 10479, "first_name": "Clifford", "last_name": "Bowers", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "In this project funded by the Chemical Measurements and Imaging program of the Chemistry Division, Professors Clifford R Bowers and Wenyu Huang and their groups at the University of Florida and Iowa State University seek to understand the SWAMP effect (surface waters are magnetized by parahydrogen), a recently discovered phenomenon which could significantly increase the sensitivity of molecular analysis by magnetic resonance in aqueous media - a key challenge for improving, for example, medical magnetic resonance imaging (MRI). The SWAMP effect could provide an inexpensive, portable, and continuously generated source of \"hyper-magnetized\" water needed for some types of MRI, offering an alternative to the expensive, high-maintenance approaches normally used. Hence, the SWAMP effect could facilitate medical diagnostic MRI in remote or impoverished areas. The concepts are adapted for outreach presentations to high school students through coordination with several programs in the University of Florida?s Center for Precollegiate Education and Training (CPET). At Iowa State, related outreach activities include science shows and involvement of undergraduates and high school students in suitable research activities.\n\nThis project is inspired by the recent discovery of surface-mediated proton hyperpolarization of liquid water, methanol, and ethanol by heterogeneous catalysis over Pt3Sn intermetallic nanoparticles (iNPs) sheathed in mesoporous silica (Pt3Sn@mSiO2). Guided by theory, structure/activity correlations are systematically studied as a function of the catalyst properties (e.g. surface structure, composition, particle sizes, encapsulation shell termination) and reaction conditions (temperature, magnetic field, solvent composition (chemical and isotopic)). Variation of catalyst properties is based on well-established principles of heterogeneous catalysis involving the d-band center and electronegativity properties of the constituent atoms. The goals of this project are to (1) understand the mechanism underpinning the SWAMP effect, (2) use the mechanistic understanding to develop new catalysts to increase the efficiency of the SWAMP process, (3) explore the generality of the NMR signal enhancement on a variety of neat liquids and solutions, and (4) investigate potential applications. The research and outreach plans are being carried out by an interdisciplinary team of chemists ? a catalyst materials specialist (Wenyu Huang, Iowa State University), an NMR spectroscopist (Russ Bowers, University of Florida), and a computational chemist (Graeme Henkelman, University of Texas, Austin).\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2801", "attributes": { "award_id": "1915614", "title": "Adapting an Experiment-centric Teaching Approach to Increase Student Achievement in Multiple STEM Disciplines", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "IUSE" ], "program_reference_codes": [], "program_officials": [ { "id": 8325, "first_name": "John", "last_name": "Jackman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-11-01", "end_date": "2023-10-31", "award_amount": 1500008, "principal_investigator": { "id": 8329, "first_name": "Oludare", "last_name": "Owolabi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 291, "ror": "https://ror.org/017d8gk22", "name": "Morgan State University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 8326, "first_name": "Md M", "last_name": "Rahman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 8327, "first_name": "Krishna", "last_name": "Bista", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 8328, "first_name": "Uttam", "last_name": "Gaulee", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 291, "ror": "https://ror.org/017d8gk22", "name": "Morgan State University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "With support from the NSF Improving Undergraduate STEM Education Program: Education and Human Resources (IUSE:EHR), this project aims to serve the national interest by implementing an evidence-based, experiment-focused teaching approach in multiple STEM disciplines. The Experiment Centric Pedagogy (ECP) has been successful in promoting motivation and enhancing academic achievement of electrical engineering students. ECP uses an inexpensive, safe, and portable electronic instrumentation system that can be used in classrooms and student laboratories. When paired with appropriate software and sensors, it can be used to measure a wide range of properties, from vibration to oxygen levels. In this Engaged Student Learning project, ECP will be adapted for use in biology, chemistry, civil engineering, computer science, industrial engineering, transportation systems, and physics. Because using electronic instrumentation to make scientific measurements is common in all STEM disciplines, ECP may be an especially valuable STEM teaching approach. \n\nThis project will adapt and implement ECP, as well as assess the impact of ECP on student success measures. The first project objective is to provide workshops at which STEM faculty will learn how to use ECP as an active learning pedagogy. These workshops will be open to all STEM faculty, not just project faculty. Non-project faculty might adopt ECP, thereby yielding secondary project benefits. The second objective is to integrate ECP into multiple STEM disciplines and in various settings, such as in traditional classrooms and teaching laboratories, and at home use by students. Instructors may implement ECP for in-class demonstrations, for cooperative group experiments in class or laboratories, and for homework assignments. Project faculty will be supported from early ECP adaptation through implementation and assessment. The third objective is to measure student success outcomes resulting from the use of ECP. Student success will be measured by academic performance as well as retention and graduation rates. In addition, validated instruments will be used to measure key constructs associated with student success, such as motivation, epistemic and perceptual curiosity, engineering identity, and self-efficacy. Results of formative assessments are expected to guide the project, and the summative project assessment is expected to demonstrate positive impacts on more than 1,000 STEM students, a considerable proportion of whom are from groups historically underrepresented in STEM. The NSF IUSE: EHR Program supports research and development projects to improve the effectiveness of STEM education for all students. Through the Engaged Student Learning track, the program supports the creation, exploration, and implementation of promising practices and tools.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10463", "attributes": { "award_id": "2119299", "title": "Collaborative Research: PPoSS: LARGE: Principles and Infrastructure of Extreme Scale Edge Learning for Computational Screening and Surveillance for Health Care", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)", "PPoSS-PP of Scalable Systems" ], "program_reference_codes": [], "program_officials": [ { "id": 637, "first_name": "Wei", "last_name": "Ding", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-10-01", "end_date": "2026-09-30", "award_amount": 2127227, "principal_investigator": { "id": 26470, "first_name": "Fan", "last_name": "Ye", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26469, "first_name": "Elinor R", "last_name": "Schoenfeld", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 578, "ror": "", "name": "SUNY at Stony Brook", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This project investigates a completely new cross-disciplinary concept of “Computational Screening and Surveillance (CSS)” that utilizes edge learning to detect early indicators of diseases, and monitor health changes in both individuals and populations. CSS analyzes and interprets continuous and heterogeneous physical and physiologic sensing-data streams of human subjects to produce real-time information, knowledge, and insights about their health status. The project’s novelty is a data-driven paradigm that revolutionizes the understanding, prediction, intervention, treatment, and management of acute/infectious, chronic physical and psychological diseases. The project’s impacts are enormous social and economic benefits to individuals, organizations, and the healthcare system: early detection, preemptive intervention and management can lead to greatly improved quality of care, and huge savings for multiple diseases each costing hundreds of billions of dollars every year.\n\nThe investigators design, develop and evaluate principles and solutions for CSS enabled by extreme-scale edge learning spanning four dimensions: data modalities, health conditions and data patterns, Artificial Intelligence/Machine Learning (AI/ML) algorithms and models, and individuals/populations. The design is guided by four principles: exploit scale and heterogeneity, design for uncertainty, privacy as a first-class citizen, and faults and attacks as a norm. The investigators will 1) design AI/ML algorithms for learning data patterns and correlations for diverse health conditions in both individuals and populations at extreme scales; 2) quantify theoretical bounds on the tradeoffs between security, privacy protection, and learning accuracy in order to protect against various attacks on data and models at both the edge and cloud; 3) develop programming abstractions for automated exploration of competing AI/ML methods under uncertainty, and system mechanisms to protect stream processing integrity against sensitive data disclosure and faulty/malicious analytics; and 4) devise neural architectures and accelerators for computation efficiency at the constrained edge, data efficiency using limited training sets, and human efficiency utilizing AutoML.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "3102", "attributes": { "award_id": "1937896", "title": "SBIR Phase I: Electric Blower-Based Emergency Mask Ventilator for Simple Ventilation and Monitoring During Patient Distress and Transport", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "SBIR Phase I" ], "program_reference_codes": [], "program_officials": [ { "id": 9653, "first_name": "Henry", "last_name": "Ahn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-12-15", "end_date": "2020-11-30", "award_amount": 224959, "principal_investigator": { "id": 9654, "first_name": "Michael", "last_name": "Fogarty", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1030, "ror": "", "name": "MFM LLC", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1030, "ror": "", "name": "MFM LLC", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact of this Small Business Innovation Research (SBIR) Phase I project will significantly improve the safety and outcomes for patients in emergency situations requiring intubation, a process recognized as flawed, yet performed millions of times per year in the United States. This project will enable responders to use a lightweight, portable device that will decrease the time to stabilize a patient during critical situations by developing a new device to measure the patient’s tidal volume, or volume of air moved through the lungs in a ventilation cycle. With this measurement, responders will be able to treat patients more effectively, efficiently and safely. The resulting technology of this project will not only increase safety for patients and increase efficiency of medical responders, it will do so in a cost-effective manner, making it financially feasible for buyers to assure every patient has this life-saving respiratory support. \n\nThe proposed project will further develop a device to measure tidal volume and deliver breaths using tightly controlled pressure levels and respiration rates. It will calculate and measure tidal volume, respiratory rate, and minute ventilation; furthermore, it will dynamically adapt to leaks and detect airway obstruction during emergency ventilation, providing instant and accurate feedback to responders and avoiding any possible injury to the patient. In this Phase I project we will extend prior research by building a compact device to be worn on the responder’s arm or in a sling. We will: 1) build and test smaller electronics and sensors in a prototype; 2) develop advanced monitoring algorithms; 3) conduct bench-tests on patient simulators to optimize the system; 4) conduct display and wearability tests. The end goal of this project is to provide an ultra-portable prototype that meets or exceeds the performance of ventilators normally used in intensive care unites, broadening the impact to all patients requiring lifesaving ventilation.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2855", "attributes": { "award_id": "1906874", "title": "Teen Science Cafes for Advancing STEM in Rural Places", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "AISL" ], "program_reference_codes": [], "program_officials": [ { "id": 8535, "first_name": "Toni", "last_name": "Dancstep", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-07-01", "end_date": "2022-09-30", "award_amount": 299974, "principal_investigator": { "id": 8537, "first_name": "Michelle", "last_name": "Hall", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 373, "ror": "", "name": "Science Education Solutions Inc", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 8536, "first_name": "Janice", "last_name": "Mokros", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 373, "ror": "", "name": "Science Education Solutions Inc", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "As part of its overall strategy to enhance learning in informal environments, the Advancing Informal STEM Learning (AISL) program funds innovative research, approaches and resources for use in a variety of settings. In this project, Science Cafe's have emerged over the years as a useful mechanism for exposure of scientific information to the public. More recently, this forum has been successfully used as a communication mechanism for teens. While this mechanism is successful with urban and suburban youth, it has not been efficacious with rural teens. Thus, this project is designed to ferret out the challenges faced by Teen Science Cafe's(TSCs) in rural settings and find ways to surmount them. The long-term goal is to engage a large number of teens who will enter adulthood as citizens with a sophisticated understanding of the science process and who will follow a myriad of pathways into the U.S. STEM workforce. The research will focus on what works, for whom, and where with respect to the key components and outcomes of teen science cafe's in rural areas. \n\nAt the broadest level, the project will strengthen infrastructure and build capacity by producing a national model for bringing OST (out of school time) STEM to rural communities. Over the two project years, approximately 600 unique participants will participate in teen science cafe's that engage their curiosity in STEM, provide leadership opportunities, and make STEM occupations more visible, participatory and approachable for rural teems who often lack access to high quality STEM programs in school. \n\nSpecific goals of the project for rural settings are: (1) To test the feasibility and effectiveness of a national model of professional development centered on an in-person and virtual community of practice for informal STEM educators leading teen science cafe's. (2) Form research-practice partnerships involving the PIs and the leaders of cafe's to: i) identify and document existing local conditions, resources, and challenges and their significance for OST STEM education; ii) work collaboratively with peers and the PIs to systematically test new strategies for engaging rural teens in TSCs; (3) Cultivate a mindset among teens that STEM IS EVERYWHERE. Rural teens are often isolated and the STEM careers in their communities are largely invisible to them. To date, 19 geographically and demographically diverse active teen cafe's sites have committed to the project. The PIs will use a multifaceted approach to characterizing rurality, They will use the established Index of Relative Rurality (IRR) which includes four spatial variables (remoteness, overall population size, density, and proportion of built-up land). The impact of the Cafe's series at each site will be determined via multiple methods, including: (1) pre-post-surveys with teens, employing the measure of STEM attitudes and engagement; (2) detailed blog postings by adult leaders describing the challenges/successes of teen and (3) interviews with leaders to uncover their perceptions of the reasons associated with success of the strategy.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2741", "attributes": { "award_id": "1902691", "title": "Global Dynamics of Nonlinear Dispersive Evolution Equations and Spectral Theory", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "ANALYSIS PROGRAM" ], "program_reference_codes": [], "program_officials": [ { "id": 8102, "first_name": "Marian", "last_name": "Bocea", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-07-01", "end_date": "2021-09-30", "award_amount": 270000, "principal_investigator": { "id": 8103, "first_name": "Wilhelm", "last_name": "Schlag", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 452, "ror": "https://ror.org/03v76x132", "name": "Yale University", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 452, "ror": "https://ror.org/03v76x132", "name": "Yale University", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "This project aims at understanding the propagation of waves in a wide sense. On the one hand, the PI will investigate the behavior of waves in space, as they interact nonlinearly with themselves and matter over large space-time scales. The ultimate goal is to explain how the energy, which is stored in a wave undergoing a nonlinear dynamical evolution, ultimately splits into quantized pieces and a wave \"at the horizon\". The latter refers to energy, possibly of large size, which is infinitely spread out and does not interact with anything in a noticeable fashion. In contrast with this macroscopic behavior, the project also aims at understanding the behavior of waves on the microscopic scale, such as in crystals or quasi-crystals. The goal is to explain transitions from an insulating state to that of a conductor, which these materials may exhibit as they undergo changes on the molecular level. Such changes may occur through the insertion of impurities, or changes in the environment. Both the macroscopic as well as the microscopic behavior of waves is of crucial importance to science and engineering, and profoundly affects our daily modern lives. Modern communication relies on waves transmitted over large distances both in space but also along glass fiber cables. For the latter the properties of the material are crucial and both nonlinear effects as well as aforementioned microscopic phenomena decide the suitability of the underlying medium. \n\nMore technically speaking, the PI intends to further investigate the rigorous mathematical theory of focusing dispersive semilinear evolution equations. A major open problem is to analyze the resolution of any solution into moving solitons and radiation. Some success has been achieved in recent years on this important problem, but for nonintegrable equations we are far from a satisfactory understanding. The PI is currently involved in the study of this problem in the dissipative setting in which some damping is added to the equation. The Hamiltonian setting appears to be very difficult at the moment, especially in the subcritical regime. The methods involved derive from dynamical systems, invariant manifold theory, and dispersive PDEs. The quantum mechanical problems alluded in the previous paragraph belong to the area of Anderson localization. Together with his long-standing collaborator Michael Goldstein at Toronto, but also with young collaborators which are joining the field, the PI intends to bring the body of techniques which were developed over the past 20 years based on large deviation estimates, the avalanche principle, semi-algebraic sets, and harmonic analysis such as (pluri)subharmonic functions and the Cartan estimate, to bear on both linear and nonlinear problems in dynamical systems and spectral theory. Ultimately, the goal here is also to better describe the behavior of wave propagation in disordered media.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "3248", "attributes": { "award_id": "1755348", "title": "A portal into the brain: olfactory crypt neurons modulate brain viral immunity in teleost", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Modulation" ], "program_reference_codes": [], "program_officials": [ { "id": 10224, "first_name": "Colin", "last_name": "Saldanha", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-07-01", "end_date": "2021-10-31", "award_amount": 549993, "principal_investigator": { "id": 10226, "first_name": "Irene", "last_name": "Salinas", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 170, "ror": "https://ror.org/05fs6jp91", "name": "University of New Mexico", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 10225, "first_name": "Mar", "last_name": "Huertas", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 170, "ror": "https://ror.org/05fs6jp91", "name": "University of New Mexico", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "The interactions between the nervous system and the immune system determine the interactions between animals and their environment and, therefore, the survival and success of any animal species. Previous work has demonstrated that neurons can regulate immune responses, and that if neurons are infected with pathogens, they will also mount their own immune responses. The central idea of this project is that, given their direct exposure to external microorganisms, olfactory sensory neurons are able to sense infection and initiate immune responses in very rapid ways, by using electrical signals. The work focuses on one type of olfactory sensory neuron, the crypt neuron, which is unique to fishes. The hypothesis being tested is that by expressing a tyrosine kinase receptor, crypt neurons interact with proteins present in fish viruses. This interaction results in neuronal electrical signals that travel fast to the olfactory bulb in the central nervous system of the fish. Consequently, very fast (within minutes) antiviral immune responses are mounted in the nasal epithelium via cells that migrate from the olfactory bulb to the nose. The work has broad implications, including for society, because it will reveal a new mechanism by which bony fish recognize external microbial signals in the water. Understanding of this mechanism has impacts in the field of fish biology and conservation as well as aquaculture and nasal vaccine development for fish. Additional broader impacts of this project include outreach to rural schools in New Mexico and workshops to broaden participation of women in STEM disciplines.\n\nOlfactory organs detect environmental chemical signals and send them to the central nervous system (CNS) via the olfactory bulb. At the same time, olfactory sensory neurons (OSNs) are in direct contact with microorganisms present in the environment including viruses. Teleost fish have olfactory organs that resemble those of mammals, yet they have a unique type of OSN named crypt neurons. Crypt neurons express only one type of olfactory receptor, ORA4, and the tyrosine kinase receptor TrkA. Although the function of this unique OSN subset has attracted the attention of many investigators, crypt cell function remains a mystery. The goal of this project is to test a new function for crypt neurons in teleost fish. The central hypothesis is that crypt neurons detect viruses in the environment via the TrkA receptor and oversee immune responses in the CNS to avoid inflammation-induced damage. This hypothesis is being tested in rainbow trout (Oncorhynchus mykiss) crypt neurons exposed to the salmonid virus infectious hematopoietic necrosis virus (IHNV). The investigators use their pre-established trout in vivo model and pharmacological and molecular approaches to determine how crypt neurons modulate CNS innate immune responses, as well as how TrkA-viral interactions play a role in this process. Additionally, electrophysiological approaches and nerve sectioning serve to shed light on the mechanisms by which the cross-talk between the olfactory organ and the olfactory bulb occurs. The findings will elucidate an important but overlooked neuroimmune interaction in teleosts by which CNS immune responses are orchestrated from the periphery via OSN electrical signals.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2975", "attributes": { "award_id": "1848857", "title": "Risk Markets Imbalances and Macroeconomics", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "Economics" ], "program_reference_codes": [], "program_officials": [ { "id": 9077, "first_name": "Nancy", "last_name": "Lutz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-08-01", "end_date": "2023-07-31", "award_amount": 265000, "principal_investigator": { "id": 9078, "first_name": "Ricardo", "last_name": "Caballero", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract \n\nThis project explores how changes in the demand and supply for risky assets and the imbalance between them (risk-market imbalances) affect macroeconomic outcomes. The research then considers efficient macroeconomic policy from this perspective. This research is highly relevant in the recent low interest rate environment, as monetary policy has historically been the most direct tool to prevent severe risk-markets shocks from spilling over to the real economy. When interest rates are low, traditional policies are ineffective. Furthermore, a low interest rate environment encourages speculative bubbles and high yield investment patterns that make the economy more vulnerable. These phenomena and policy responses to them impact the global economy and require an internationally coordinated response. This research will generate new analytical tools to integrate financial and macroeconomic analysis. It will also explore optimal policy responses to macroeconomic outcomes by considering the impact of risk-market imbalances on the real economy. \n\nThis project examines the interactions between risk-shocks and constraints on monetary policy in generating economic fluctuations, the role of financial speculation and its drivers in exacerbating the severity of these fluctuations, and the optimal joint monetary, fiscal, and macroprudential policy framework for this environment. Specifically, the research examines risk-off episodes with a zero-lower bound (ZLB) on interest rates that incorporates a broader set of constraints, including political economy concerns. The research will also explore, both theoretically and empirically, the role of leverage and how it responds to different policy frameworks. The project further incorporates speculative bubbles and behavioral elements in this framework. On the international front, the research will develop and test models of gross capital flows and exchange rate movements during both global and local risk-off episodes. The project will then explore optimal international coordination mechanisms to deal with global cycles in a low interest rate environment.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2711", "attributes": { "award_id": "1928488", "title": "Engineering Technology Challenge", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "Advanced Tech Education Prog" ], "program_reference_codes": [], "program_officials": [ { "id": 7993, "first_name": "John", "last_name": "Jackman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-03-15", "end_date": "2021-09-30", "award_amount": 353043, "principal_investigator": { "id": 7994, "first_name": "mehrdad", "last_name": "faezi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 935, "ror": "https://ror.org/00p511b69", "name": "Education Connection", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 935, "ror": "https://ror.org/00p511b69", "name": "Education Connection", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "The Engineering Technology Challenge (ETC) program is a collaboration among Connecticut community colleges, three inner-city high schools, industry, the Connecticut Business and Industry Association (CBIA), and Catalysts Powering Educational Performance (CPEP Inc.) to engage a diverse group of underrepresented students from urban comprehensive high schools in Saturday and summer programs focused on manufacturing technology. The program will create teams of high school students, mentored by community college students, faculty, and industry professionals in industry-driven problem based learning (PBL) projects, including the integration of professional skills and teamwork. \n\nSpecifically, the ETC Program will develop and implement: 1) after-school programs for high school students, using industry and interest driven PBL projects; 2) career and college readiness workshops; 3) summer learning experiences including industry internships; 4) high school teacher summer workshops using the PBL curriculum and hands-on kits developed in ETC; 5) manufacturing career pathway experiences for career counselors, STEM high school teachers and parents; and 6) participation in Mini Maker Faires. Diversity is a core goal of ETC, directly impacting approximately 240 inner-city/under-represented high school students and 75 high school teachers. Through teacher professional development workshops, another 7500 students are indirectly impacted (~100 students per teacher). ETC will contribute to preparation of students for continuing their career pathway in manufacturing technology through credit certificates and degrees at partner community colleges and universities; and for high-tech jobs in the advanced manufacturing workforce. Project evaluation efforts will contribute to the general knowledge base regarding the attributes and practices of successful after school and summer programs for secondary school students, as well as associated professional development for teachers, that are carried out in collaboration with community college faculty and industry mentors.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10737", "attributes": { "award_id": "2212920", "title": "SBIR Phase II: A Rapid, Sensitive Pathogen Typing and Antibiotic Sensitivity Test for Bloodstream Infections (COVID-19)", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "SBIR Phase II" ], "program_reference_codes": [], "program_officials": [ { "id": 773, "first_name": "Erik", "last_name": "Pierstorff", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-12-01", "end_date": "2024-11-30", "award_amount": 999999, "principal_investigator": { "id": 2057, "first_name": "Rachel", "last_name": "Tinker-Kulberg", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 445, "ror": "", "name": "Kepley Biosystems Incorporated", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 445, "ror": "", "name": "Kepley Biosystems Incorporated", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact of this Small Business Innovation Research (SBIR) Phase II project seeks to develop an improved era of infectious disease management, allowing rapid intervention for antibiotic therapy to stem the 30% mortality rate and associated cost impact of sepsis. With some 49 million cases worldwide and a 25-30% mortality rate, sepsis claims 11 million lives annually. Sepsis cases have been increasing 8.7% per year. To address the full spectrum of infectious diseases, innovations must deliver simple and affordable testing capabilities similar to routine hospital admission blood analyses. The proposed antifungal and antibacterial susceptibility test for the detection and treatment of bloodstream infections could benefit patients by improving patient management and hospital logistics. Sepsis is the most expensive healthcare challenge, with an estimated financial impact of more than $62 billion per year. This bloodstream infection screening assay could impact the entire continuum of care – from initial hospital interactions through patient care and discharge – by identifying infections early, optimizing treatment, and increasing survival. Direct customer survey-based estimates and independent information sources project a U.S. commercial opportunity of 226 million annual assays (36 million hospital admissions, 40 million intensive care patients, 130 million emergency walk-ins, and 20 million presurgical evaluations).\n \nThe proposed project could result in the development of a user-friendly and affordable analytical tool for early detection of bloodstream infections that differentiates bacterial and fungal pathogens associated with sepsis and determine their antibiotic sensitivity in hours. Sepsis is a major public health and economic concern that results in one human death every 2.8 seconds. If bloodstream infections go undetected or untreated, patients can quickly escalate into sepsis or septic shock with mortality chances increasing by 8% per hour without appropriate antibiotic administration. Rapid and accurate detection of a bloodstream infections prior to the onset of sepsis is critical to limit the extent of tissue and organ damage, mortality, and associated hospital costs. The proposed innovation includes the use of an FDA-approved reagent called Limulus Amebocyte Lysate for clinical bloodstream infections and antifungal antibacterial susceptibility testing to guide therapeutic interventions, and routine surveillance of high-risk patient populations. The technical approach for this Phase II encompasses proficiency studies that would validate high-throughput detection of pathogens, as well as their antimicrobial sensitivity and resistance profiles in clinical blood specimens. Additionally, assay miniaturization and automation would be performed and are considered critical for future in vitro diagnostic partnership adoption.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 5, "pages": 1442, "count": 14420 } } }