Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=5&sort=-other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=-other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=6&sort=-other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-other_investigators" }, "data": [ { "type": "Grant", "id": "15938", "attributes": { "award_id": "3U01AI069911-20S3", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 276896, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15941", "attributes": { "award_id": "3U01AI069911-20S5", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 195343, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15940", "attributes": { "award_id": "3U01AI069911-20S4", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 747173, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15936", "attributes": { "award_id": "3U01AI069911-20S1", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 317911, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15939", "attributes": { "award_id": "3U01AI069911-20S2", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 121192, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15938", "attributes": { "award_id": "3U01AI069911-20S3", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 276896, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15941", "attributes": { "award_id": "3U01AI069911-20S5", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 195343, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15937", "attributes": { "award_id": "3U01AI069911-20S6", "title": "East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 44382, "first_name": "JOANAD'ARC C", "last_name": "ROE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 47470, "principal_investigator": { "id": 44383, "first_name": "AGGREY SEMWENDERO", "last_name": "SEMEERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44384, "first_name": "Kara Kay", "last_name": "Wools-Kaloustian", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 44385, "first_name": "CONSTANTIN THEODORE", "last_name": "YIANNOUTSOS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3402, "ror": "", "name": "INDIANA UNIVERSITY INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.", "keywords": [ "2019-nCoV", "AIDS related cancer", "Achievement", "Acquired Immunodeficiency Syndrome", "Address", "Adolescent and Young Adult", "Affect", "Africa", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Cervical", "Clinic", "Clinical", "Collaborations", "Communities", "Country", "Data", "Data Sources", "Databases", "Dermatology", "Development", "Diagnosis", "Disease", "Environment", "Epidemiology", "Evolution", "Funding", "Gender", "Genetic", "Geography", "Goals", "Government", "Grant", "HIV", "HIV/AIDS", "Health", "Health Care", "Home", "Image", "Infant", "International", "Joints", "Kaposi Sarcoma", "Kenya", "Knowledge", "Learning", "Liver diseases", "Longevity", "Machine Learning", "Malignant Neoplasms", "Malignant neoplasm of cervix uteri", "Measures", "Mental Depression", "Mental Health", "Methodology", "Methods", "Movement", "Newborn Infant", "Operations Research", "Outcome", "Patient-Focused Outcomes", "Patients", "Persons", "Policies", "Pregnancy", "Public Health", "Research", "Resource-limited setting", "Risk Factors", "Sampling", "Sentinel", "Statistical Methods", "Structure", "Tanzania", "Technology", "Telemedicine", "Treatment outcome", "Tuberculosis", "Tuberculosis diagnosis", "Uganda", "United Nations", "Viral", "age group", "antiretroviral therapy", "cancer diagnosis", "cardiovascular risk factor", "care outcomes", "co-infection", "cohort", "comorbidity", "contextual factors", "eHealth", "experience", "implementation evaluation", "implementation research", "insight", "new technology", "novel", "post-COVID-19", "programs", "pulmonary", "scale up", "substance use", "syndemic", "telehealth", "tool", "treatment guidelines", "treatment program", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "15930", "attributes": { "award_id": "1R24AI192250-01", "title": "Repository of Monoclonal Antibodies (RoMA) against Hamster and Guinea Pig Proteins", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32843, "first_name": "JOSEPH J", "last_name": "BREEN", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-07-24", "end_date": "2030-06-30", "award_amount": 835137, "principal_investigator": { "id": 44375, "first_name": "JAMES A", "last_name": "DUTY", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 44376, "first_name": "Domenico", "last_name": "Tortorella", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 3386, "ror": "", "name": "ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Small animal models are ideal to study diverse infectious and inflammatory diseases with mice being a widely used model system due to the well-characterized immune response and availability of reagents. Yet, the drawbacks of the mouse animal model are that it does not mimic many diseases due to the lack of clinical symptoms, differences in immune activation, and non-susceptible to infection of many pathogens. In fact, ferrets, Guinea pigs, and hamsters are a more suited animal model for numerous infectious pathogens including bat coronaviruses (SARS-CoV and SARS-CoV-2), influenza virus, and respiratory syncytial virus, respectively; yet, the lack of reagents that define the immune and inflammatory responses in ferrets, Guinea pigs, and hamsters prevent their utilization to comprehensively understand disease pathology and effectiveness of therapeutics and vaccines. Thus, there is a severe reagent gap for monoclonal antibodies against immune and inflammatory markers of ferrets, Guinea pigs, and hamsters to use these animal models in infectious disease studies. The main objective of the R24 application is to create a Repository of Monoclonal Antibodies (RoMA) for use in small animal models for evaluating infectious and inflammatory disorders fulfilling a major reagent gap in the scientific community. We hypothesize that reagents that monitor the immune response in hamster and Guinea pig model systems will be widely used in infectious disease model systems to predict disease progression and effectiveness of vaccines and therapeutics in human disease. A panel of monoclonal antibodies will be generated upon completion of the following aims: Aim 1: Develop antibodies targeting hamster and guinea pig surface markers on the respective immune cells. The hamster has become an excellent model for respiratory pathogens including SARS-corona viruses, Rift Valley fever, and Clostridium difficile; while the Guinea pig animal model provides insight into numerous infection and transmission models such as influenza virus and herpesviruses. Aim 2: Identify and generate monoclonal antibodies to hamster and guinea pig immune cell activation markers. We plan to identify and generate monoclonal antibodies to activated immune cell immune markers of hamster and Guinea pigs. These activated biomarkers will consist of previously characterized human and mouse orthologs that likely function in immune regulation. We expect to generate a total of 50 monoclonal antibodies (25 anti-hamster and 25 anti-Guinea pig proteins) over the 5-year grant period that will be available to the scientific community. These antibodies will be essential for evaluating the immune and inflammatory responses in the hamster and Guinea pig animal models.", "keywords": [ "2019-nCoV", "Animal Model", "Animals", "Antibodies", "B-Lymphocytes", "Bacterial Infections", "Biological Markers", "Biological Models", "Blood", "Cavia", "Cell surface", "Cells", "Chiroptera", "Clinical", "Clinical Pathology", "Clostridium difficile", "Communicable Diseases", "Communities", "Coronavirus", "Dendritic Cells", "Disease", "Disease Progression", "Evaluation", "Ferrets", "Grant", "Hamsters", "Herpesviridae", "Human", "Immune", "Immune System Diseases", "Immune response", "Immunologic Factors", "Immunologic Markers", "Immunologic Monitoring", "Immunologic Stimulation", "Infection", "Infectious Agent", "Inflammatory", "Inflammatory Response", "Laboratories", "Lymphoid", "Lymphoid Cell", "Macrophage", "Modeling", "Monoclonal Antibodies", "Mouse Protein", "Mus", "Myelogenous", "Myeloid Cells", "Natural Killer Cells", "Orthologous Gene", "Oryctolagus cuniculus", "Pathology", "Phenotype", "Physiology", "Prevention", "Proteins", "R24", "Rattus", "Reagent", "Research", "Respiratory syncytial virus", "Rift Valley Fever", "SARS coronavirus", "Scientific Advances and Accomplishments", "Spleen", "Surface", "Symptoms", "T-Lymphocyte", "Therapeutic", "Transgenic Animals", "Treatment Efficacy", "United States National Institutes of Health", "Vaccines", "Virus Diseases", "Zebrafish", "animal model selection", "cost", "cross reactivity", "design", "diagnostic tool", "guinea pig model", "human disease", "immune activation", "immunological status", "immunoregulation", "infectious disease model", "inflammatory marker", "influenzavirus", "insight", "monocyte", "neutrophil", "next generation sequencing", "nonhuman primate", "pathogen", "preclinical study", "prevent", "programs", "repository", "respiratory pathogen", "response", "therapeutic effectiveness", "transmission process", "vaccine effectiveness", "vaccine efficacy" ], "approved": true } }, { "type": "Grant", "id": "15927", "attributes": { "award_id": "1U01DA063078-01", "title": "A binational cohort of the intersection between substance use, HIV, and associated comorbidities among people who inject drugs in San Diego, CA", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 44370, "first_name": "SHEBA KING", "last_name": "DUNSTON", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-07-15", "end_date": "2030-05-31", "award_amount": 2437310, "principal_investigator": { "id": 23320, "first_name": "STEFFANIE A.", "last_name": "STRATHDEE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 760, "ror": "https://ror.org/0168r3w48", "name": "University of California, San Diego", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 44371, "first_name": "Britt", "last_name": "Skaathun", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2637, "ror": "", "name": "UNIVERSITY OF CALIFORNIA, SAN DIEGO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "We will prospectively study the intersection between substance use, HIV and related co-morbidities in a cohort of people who use drugs (PWUD) in San Diego County (SD). For >25 years, Strathdee has studied the epidemiology of HIV and related co-infections among PWUD across North America, with N=500-1000 and annual retention ≥90%. Since 2020, our La Frontera I cohort situated on the U.S.-Mexico border has documented the highest HIV and HCV incidence among people who inject drugs in North America. Currently, HIV prevalence among former injectors in SD is 16% compared to 10% among current injectors. Consistent with other U.S. cities, we observed a dramatic shift from injection to non-injection of opiates in recent years, leading us to propose cohort expansion to non-injectors. Due to our location on a major drug trafficking corridor, we observe a wide range of substances (e.g., heroin, fentanyl, methamphetamine, xylazine, benzodiazepines). We previously leveraged La Frontera I to evaluate initiatives to improve uptake of PrEP, COVID-19 testing and vaccination. We propose: 1) To characterize trends and predictors of use of established and emerging drugs, drug use transitions (e.g., shifts from IDU to non-IDU & vice versa) and their impact on HIV incidence and utilization of HIV prevention and treatment. 2) To study prevalence and incidence of the following co-morbidities and their relationship to HIV incidence and utilization of HIV prevention and treatment: i) HCV; ii) STIs (i.e., syphilis, gonorrhea, Chlamydia, MPox), iii) neurobehavioral disturbances. 3) To evaluate the influence of structural interventions on HIV-related risk behaviors and utilization of HIV prevention and treatment including: i) new homelessness policies; ii) drug checking services; iii) vending machines. 4) To contribute to a shared database and biorepositories that serve as a platform for collaborations with end users and community partners. To meet these aims, we will continue to follow PWUD from La Frontera I who are actively using illicit substances, replenishing to arrive at 500 PWID and 500 PWUD (non-injectors) for a total sample of 1000. This will include subgroups vulnerable to HIV in SD (e.g., sex workers, people experiencing homelessness) among whom we expect 52 HIV seroconversions after 5 years of follow-up. Our cohort will include at least 50 PWUD living with HIV who will provide samples for viral load, sequencing and biobanking. All participants will undergo semi-annual interviews and specimen collection. SD is designated as a high priority jurisdiction for the Ending the HIV Epidemic Initiative (EHE) and a high intensity drug trafficking area by the DEA. La Frontera II leverages NIH-funded T32s, the California NeuroHIV Tissue Network, Last Gift Study brain/tissue repositories and the PREPARE Institute which tracks emerging and re-emerging infectious disease threats. Our work is aligned with priorities identified by RFA-DA-25-003, the NIH Office of AIDS Research and the EHE.", "keywords": [ "AIDS prevention", "Area", "Benzodiazepines", "Biological", "Border Crossings", "Brain", "COVID-19", "COVID-19 testing", "COVID-19 vaccination", "California", "Chlamydia", "Cities", "Collaborations", "County", "Coupled", "Drug usage", "Drug user", "Emerging Communicable Diseases", "Environmental Exposure", "Epidemic", "Epidemiology", "Fentanyl", "Functional disorder", "Funding", "Gifts", "Goals", "Gonorrhea", "HIV", "HIV Seropositivity", "HIV risk", "HIV/HCV", "Harm Reduction", "Health", "Hepatitis C Incidence", "Hepatitis C virus", "Heroin", "Homelessness", "Incidence", "Infectious disease threat", "Injecting drug user", "Injections", "Intervention", "Interview", "Lived experience", "Location", "Meta-Analysis", "Methamphetamine", "Mexico", "Modeling", "Molecular Epidemiology", "Monkeypox", "Mood Disorders", "NIH Office of AIDS Research", "National Institute of Drug Abuse", "Needle Sharing", "Neurocognitive", "North America", "Opioid", "Participant", "Pattern", "Persons", "Pharmaceutical Preparations", "Policies", "Positioning Attribute", "Postdoctoral Fellow", "Prevalence", "Prevalence Study", "Prospective Studies", "Prospective cohort", "Prospective cohort study", "Research", "Research Priority", "Risk Behaviors", "Sample Size", "Sampling", "Services", "Statutes and Laws", "Subgroup", "Syphilis", "Testing", "Tissue Banks", "Tissues", "Travel", "United States National Institutes of Health", "Viral Load result", "Visit", "Work", "Xylazine", "biobank", "co-infection", "cohort", "community partners", "comorbidity", "data sharing", "end of life", "epidemiology study", "experience", "fentanyl use", "follow-up", "housing instability", "improved", "member", "neuroAIDS", "neurobehavioral", "novel", "pre-doctoral", "pre-exposure prophylaxis", "prevention service", "recruit", "repository", "response", "retention rate", "sample collection", "seroconversion", "severe mental illness", "sex", "shared database", "sociodemographics", "substance use", "syndemic", "synthetic drug", "systematic review", "trafficking", "transmission process", "treatment services", "trend", "uptake" ], "approved": true } } ], "meta": { "pagination": { "page": 5, "pages": 1442, "count": 14420 } } }