Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=5&sort=-award_id
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-award_id", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=-award_id", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=6&sort=-award_id", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-award_id" }, "data": [ { "type": "Grant", "id": "2811", "attributes": { "award_id": "7R21AI164080-02", "title": "Understanding how the MERS Coronavirus protein ORF4b interactions with importin alpha modulate innate immunity", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 8363, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-07-01", "end_date": "2023-06-30", "award_amount": 186654, "principal_investigator": { "id": 8364, "first_name": "Christopher F", "last_name": "Basler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The Middle East respiratory syndrome coronavirus (MERS-CoV), is a highly pathogenic, zoonotic, non-segmented, positive-sense RNA virus related to the severe acute respiratory syndrome coronavirus (SARS CoV) and SARS-CoV-2 that can spread from person to person. The potential threat posed by zoonotic coronaviruses is demonstrated by the emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic. Because MERS CoV remains a threat, an understanding of mechanisms of MERS CoV replication, particularly as these related to pathogenesis and therapeutic development, remains critical. ORF4b (4b) is notable among the MERS CoV accessory proteins because it strongly localizes to the nucleus, despite virus replication occurring in the cytoplasm, and it exerts innate immune evasion functions. These include inhibition of interferon beta (IFNβ) and IFNλ production and inhibition of NF-κB-dependent cytokine production. The 4b protein also inhibits the 2’, 5’ oligoadenylate synthetase (OAS)-RNase L pathway, an activity attributed to its C-terminal phosphodiesterase domain. ORF4b is a nuclear protein and both transfection- and infection-based assays indicate that mutation of the apparent ORF4b nuclear localization signal (NLS) impairs affects inhibition of innate immune evasion functions. One notable study found that 4b blocks NF-ĸB-dependent responses and this correlated with the capacity of 4b to outcompete the p65 subunit of NF-ĸB for IMPA3 binding. We have undertaken X ray crystallography studies of the 4b-IMPA interaction. Our Preliminary Data demonstrate that 4b has uniquely bypassed canonical rules of NLS recognition and does not contain a Lys residue at a binding site formerly thought to be critical for NLS function. Further, the proposed specificity of 4b for IMPA3 is not fully supported by our data. We found that the NLS region of 4b binds IMPA2 and with an interface that is more extensive than IMPA3. Thus, the specificity that has been proposed is unlikely to be mediated by this simple interaction interface. Furthermore, if 4b is able to bind a greater range of IMPA isoforms than had previously been proposed, this MERS-CoV protein is likely to be able to competitively inhibit the nuclear import of other innate immune transcription factors such as IRF3 and STAT1. Consistent with such a model, Preliminary Data of crystal structures of the p50 NF-κB NLS bound to IMPA2 and IMPA3 demonstrate that these regions overlap with MERS ORF4b. Based on these observations, we propose to solve structures of full-length and NLS peptides of MERS- CoV and bat Merbecovirus ORF4b proteins in complex with nuclear receptor IMPA isoforms and define interaction interfaces. .This will provide a structural basis for the specificity of ORF4b binding and nuclear import. To compare the structural data obtained for ORF4b and IMPAs, we will determine the structures of IMPA isoforms in complex with NF-κB to establish a structural basis for the immune evasion. Finally. we will test the hypothesis that ORF4b inhibits NF-κB signaling and IFN production by competing for p50-IMPA interaction in transfection-based and virus infection studies.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10215", "attributes": { "award_id": "7R21AI163282-02", "title": "DiagnosDisk - a highly sensitive point-of-care test for detecting SARS-CoV-2antigen in saliva", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6011, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-02-01", "end_date": "2023-05-31", "award_amount": 134168, "principal_investigator": { "id": 11756, "first_name": "James", "last_name": "Lai", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1896, "ror": "https://ror.org/00q09pe49", "name": "National Taiwan University of Science and Technology", "address": "", "city": "", "state": "TW-TPQ", "zip": "", "country": "TAIWAN", "approved": true }, "abstract": "SARS-CoV-2, a global pandemic, has caused more than 6 million infections and 180,000 deaths in the United States alone during the past 7 months. Both the WHO and CDC emphasize the need for point-of-care (POC) tests to expand diagnosis of acute infections to control the pandemic (i.e. isolating infected individuals). The current gold standard test for diagnosing acute SARS-CoV-2 infection is reverse transcriptase polymerase chain reaction (RT-PCR) with nasopharyngeal samples. The assay is highly sensitive, but requires well-trained personnel for sample collection and locations with specialized equipment. Therefore, the turnaround time varies from one to few days, delaying isolation, contact tracing, and medical attention. These challenges can be addressed with lateral flow immunoassays (LFIA) to detect viral antigens in self-collected saliva samples. Compared to nasopharyngeal specimens, studies have demonstrated that assays with saliva samples are more consistent and the saliva itself may contain higher viral load. However, existing LFIA for detecting salivary antigens exhibit poor sensitivity (≤ 40%) caused by the use of small sample volumes and sample dilution. To achieve timely and accurate screening of suspected COVID-19 cases, this project aims to develop a rapid assay for detecting SARS-CoV-2 antigens in saliva with high sensitivity to meet WHO's target product profile. We hypothesize that using ≥500 µL saliva as the assay sample can significantly improve the sensitivity because a larger specimen volume provides more analytes for detection. The new test will employ temperature-responsive polymer-antibody conjugates in conjunction with DiagnosDisk, a novel flow-through assay device. The approach is innovative in in using enriched saliva specimens for more consistent assay results, enhancing antigen detection by scaling up the saliva specimen volume, and adopting the well- developed sandwich immunoassay for DiagnosDisk with temperature-responsive polymer reagents that simplify the design while maximizing the sensitivity. We will employ polymer-antibody conjugates that efficiently isolate analytes in saliva (Aim 1) and fabricate the DiagnosDisk device to accommodate larger volume saliva specimens to improve the detection limit (Aim 2). The sensitivity of the new rapid assay, which combines polymer-antibody conjugates and DiagnosDisk, will be evaluated using saliva specimens from COVID-19 positive and negative patients (Aim 3).", "keywords": [ "2019-nCoV", "Acute", "Address", "Adopted", "Antibodies", "Antigens", "Biological Assay", "Blood Plasma Volume", "COVID-19", "COVID-19 detection", "COVID-19 pandemic", "COVID-19 patient", "COVID-19 screening", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Contact Tracing", "Coupling", "Data", "Deposition", "Detection", "Development", "Devices", "Diagnosis", "Early Diagnosis", "Enzyme-Linked Immunosorbent Assay", "Equipment", "Evaluation", "Exhibits", "Goals", "Gold", "Gold Colloid", "Human Resources", "Hydrophobicity", "Image", "Immunoassay", "Individual", "Infection", "Lateral", "Location", "Malaria", "Measures", "Membrane", "Noise", "Nucleocapsid", "Patients", "Plasma", "Polymers", "Precipitation", "Prostate-Specific Antigen", "Proteins", "Reagent", "Reverse Transcriptase Polymerase Chain Reaction", "SARS coronavirus", "SARS-CoV-2 antigen", "SARS-CoV-2 infection", "SARS-CoV-2 negative", "SARS-CoV-2 positive", "Saliva", "Salivary", "Sampling", "Scanning", "Sensitivity and Specificity", "Signal Transduction", "Specimen", "Temperature", "Testing", "Time", "Training", "United States", "Viral Antigens", "Viral Load result", "Virus", "Visual", "acute infection", "antibody conjugate", "antigen binding", "antigen detection", "design", "detection assay", "detection limit", "hydrophilicity", "improved", "innovation", "medical attention", "novel", "pandemic disease", "point of care testing", "rapid test", "saliva sample", "salivary assay", "sample collection", "scale up", "screening", "success", "viral RNA" ], "approved": true } }, { "type": "Grant", "id": "8565", "attributes": { "award_id": "7R21AI161104-02", "title": "VPS34 inhibitors as SARS-CoV-2 antivirals", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6011, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-01", "end_date": "2023-07-31", "award_amount": 415889, "principal_investigator": { "id": 8360, "first_name": "Christopher F", "last_name": "Basler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "SARS-CoV-2, a Betacoronavirus genus, is an enveloped positive-sense, RNA virus responsible for a current pandemic. Because of its profound impact on society and human health there is an urgent need to understand SARS-CoV-2 replication requirements and to identify therapeutic strategies. Repurposing drugs developed for other purposes may provide a shortcut to therapeutic development. The use of compounds known to target specific host factors may also elucidate key pathways needed for virus replication. Coronavirus (CoV) replication involves multiple critical interactions with host cell membranes. One of the most striking features of CoV infection is the establishment of membrane-associated replication organelles that serve as the main sites of viral RNA synthesis. The origin of these membrane organelles is incompletely understood. Because the specific host pathways required for SARS-CoV-2 replication organelle formation are not defined, we asked whether SARS-CoV-2 is susceptible to modulators of lipid metabolism by assessing the sensitivity of the virus to VPS34 inhibitors of VPS34, a lipid kinase required for autophagy and endosomal trafficking; Triacsin C, an inhibitor of long chain fatty acyl CoA synthetase (ACSL) and Orlistat, an inhibitor of fatty acid synthase (FASN). Our preliminary data indicate that inhibitors of VPS34 potently inhibited SARS-CoV-2 replication, whereas an FDA- approved inhibitor of a different class of PI3K had minimal effect on replication. Targeting FASN and ACSL also impairs SARS-CoV-2 replication. These data suggest that VPS34, ACSL and FASN play important roles in replication center formation and virus growth and suggest these enzymes as therapeutic targets. We will test the hypothesis that VPS34, ACSL and FASN are critical for SARS-Cov-2 infection by evaluating additional small molecule inhibitors of these enzymes and by measuring SARS-CoV-2 replication in genetic knockdowns or knockouts of these host enzymes. We will define mechanisms of inhibition and test the hypothesis that generation of membrane-associated viral replication centers will be disrupted. Finally, we will assess the in vivo efficacy of VSP34 inhibitor PIK-III and systemically administered Orlistat in SARS-coV-2- infected hamsters to evaluate the therapeutic potential of inhibitors of lipid metabolism.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6409", "attributes": { "award_id": "7R21AI157606-02", "title": "Exosome-display as a strategy to enhance the immunogenicity of SARS-CoV-2 vaccines based on adenoviral vectors", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 21550, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-07-01", "end_date": "2023-06-30", "award_amount": 420520, "principal_investigator": { "id": 21551, "first_name": "Lynda", "last_name": "Coughlan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 793, "ror": "", "name": "UNIVERSITY OF MARYLAND BALTIMORE", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "SUMMARY: The emergence of the SARS-CoV-2 coronavirus (CoV) highlighted our lack of preparedness, and has emphasized the importance of rapidly building capacity in the development of reagents, tools, diagnostics and therapeutics for SARS-CoV-2 and related CoVs with pandemic potential. An immediate goal is to produce a vaccine which can elicit rapid, high-level protective immunity against SARS-CoV-2, ideally following a single- shot. Several candidate vaccines have now advanced into clinical trials. However, a longer term goal is to investigate the possibility for a “universal” CoV vaccine, a vaccine or prime:boost vaccination regimen which provides durable and broadly cross-reactive immunity against CoVs with high potential for spillover from bats. The CoV surface spike (S) glycoprotein is a major target for neutralizing antibodies (NAbs) and T cells, and is an attractive target for vaccine design. NAbs which target the receptor binding domain (RBD) confer protection, but are usually strain-specific and lack breadth. The existence of broadly reactive, protective epitopes outside of the RBD are not well-characterized. Therefore, vaccines which compare full length or truncated, stabilized variants of the S immunogen, could shed some light into potential correlates of protection. Another important concern is disease enhancement, which has been observed for related CoV vaccines using selected vaccine delivery platforms such as the whole-inactivated virus (WIV) vaccine. This has been associated with a Th2- biased immune response and to overcome this issue, CoV vaccines should elicit a largely Th1 biased response. Therefore, studies which aim to compare the phenotype of immunity elicited by different vaccine platforms, and to different variants of the S immunogen, could help to better understand which components of the immune response are optimal in mediating protection, without the risk of immunopathology upon infection. We will develop a potently immunogenic, optimized vaccine platform for SARS-CoV-2 using three approaches. (1) Firstly, we will engineer SARS-CoV-2 S in several different forms, a full-length immunogen, a secreted stabilized pre-fusion form or the RBD domain alone. (2) Secondly, we will augment or broaden immune recognition of pre-fusion S by targeting it to host-derived extracellular vesicles (EVs) including exosomes in vivo, by generating fusion-Ag constructs which tether Ag to a protein domain highly enriched in exosomes. Exosomes are nano-sized EVs shown to play important roles in cell:cell communication and in the regulation of immune responses, due to their ability to present Ag to T- and B-cells. (3) Finally, we will develop non-replicating, rare species adenoviral (Ad) vectored vaccines which have established protocols for rapid clinical manufacturing and regulatory approval, can be thermostabilized with minimal losses to immunogenicity and have demonstrated safety in human clinical trials. This study will comprehensively evaluate and phenotype the magnitude and profile of SARS-CoV-2 vaccines in single-shot regimens. These data will provide valuable information for the design of subsequent prime:boost regimens and for challenge experiments in the future.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11803", "attributes": { "award_id": "7R21AG073974-02", "title": "The effect of Social Isolation on Lexical Retrieval in Elderly Adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21737, "first_name": "Elizabeth Anne", "last_name": "Necka", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2024-04-30", "award_amount": 229499, "principal_investigator": { "id": 26424, "first_name": "Loraine K.", "last_name": "Obler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27664, "first_name": "AMY", "last_name": "VOGEL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1565, "ror": "https://ror.org/00g2xk477", "name": "Hunter College", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Coming up with the word we want to say (lexical retrieval) is a worrying concern among older adults. Those with dementia, naturally, experience difficulty on lexical-retrieval tasks, but typical older adults do as well. They may struggle with people’s names, but also with words for objects. Moreover, while the problems arise primarily for low-frequency words, they sometimes arise even when the word is quite familiar. Such problems with lexical retrieval appear to be compounded by the lack of speaking opportunities resulting from the social isolation that often accompanies aging in 21st century North America, and, we propose, particularly so by the extremes which have accompanied COVID-19 for many in 2020. In this project, we use a refined task to induce tip-of-the-tongue (TOT) experiences and predict that performance on that task will correlate with the degree of social isolation which our participants have endured. Moreover, increases in such communication lapses can lead to frustration, breakdowns in conversation, and, paradoxically, a desire to withdraw from social interactions in order to avoid the perception of communicative incompetence. Although substantial advances have been made in our understanding of social isolation and its influence on cognition in aging, the scope of what can be determined from measures of cognitive performance alone is limited. Most crucially, we do not yet know the effects of reduction in communication due to social isolation on word retrieval. In Study 1, we propose to retest the 53 healthy participants tested for a different project in the period leading up to COVID-19 on TOT stimuli, using items they did not see in the earlier test. A self-report of changes in social contact and communicative exchanges due to COVID-19 will allow us to gauge whether a change in social connection impacts word-finding ability. We hypothesize that poorer word-finding at the second testing will correlate positively with the degree of social isolation and negatively with the extent of social communication. In Study 2 we will conduct a larger, retrospective study of social isolation and opportunities for communicative exchanges on word-finding difficulties. We will utilize the measures from Study 1 and extend them to a broader, representative cohort of healthy older adults. We hypothesize that participants involved in social activities that require expressive language will perform better on our lexical retrieval measure, and that opportunities for communicative exchange will be negatively correlated with social isolation levels. Our findings will have a significant impact on public health because they will provide measures of how social isolation can affect communication and, for future efforts, make it possible to improve the language abilities of both healthy seniors and those with dementia.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11497", "attributes": { "award_id": "7R03HS029047-02", "title": "Telemedicine for Patients with Limited English Proficiency: A Mixed Methods Approach to Identifying and Addressing Disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 27209, "first_name": "Nora", "last_name": "Mueller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2023-12-31", "award_amount": 69138, "principal_investigator": { "id": 25512, "first_name": "Natalie Christine", "last_name": "Benda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "PROJECT ABSTRACT/SUMMARY Patients with limited English proficiency (LEP) are defined as “those who cannot effectively communicate in English”, make up nearly 9% of the U.S. patient population.13 Patients with LEP are one of the groups most underserved by the U.S. health system. They experience poorer access to care, face worse quality and safety outcomes, and report lower levels of satisfaction with their care.14–16,18 Utilization of telemedicine, the provision of remote clinical services via two-way synchronous communication, has demonstrated efficacy in certain settings and has been proposed as a general means for reducing health disparities. 1–4 5 However, studies prior to the COVID-19 pandemic have indicated patients with LEP also face disparities in accessing telemedicine-based care.20–23 As the COVID-19 pandemic continues, it is clear that telemedicine will remain part of the U.S. health system,11,12 therefore it is essential to assess how social determinants of health may affect vulnerable groups’ ability to receive equitable telemedicine-based services. We propose a mixed methods sequential explanatory design approach to identify and address barriers and facilitators related to providing telemedicine care to patients with LEP, with a focus on the intersection of other social determinants of health. Our approach will allow us to determine what may quantitatively drive disparities in utilization, which will then inform a qualitative assessment why these disparities exist and how they may be resolved.25 The specific aims are to 1) perform a longitudinal, retrospective analysis comparing telemedicine utilization and total outpatient utilization, prior to and during the COVID-19 pandemic by LEP patients to that of English proficient patients, 2) to qualitatively investigate how telemedicine visits are provided to patients with LEP through semi-structured interviews with healthcare professionals working/interacting with LEP patients (e.g. providers, community health workers) and Spanish-speaking patients with LEP. For both aims, we will consider how the multi-faceted contributions of social determinants of health relate to the delivery of high-quality, equitable telemedicine-based services to LEP patients. The results will be utilized to inform an evidence- based toolkit of best practices for equitable telemedicine delivery for patients with LEP in an outpatient setting to be evaluated in future studies.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11470", "attributes": { "award_id": "7R03HD107234-03", "title": "Telehealth in home visiting for new mothers: Are outcomes different if the first visits are in person?", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 26590, "first_name": "Monica", "last_name": "LONGO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-22", "end_date": "2024-10-31", "award_amount": 69600, "principal_investigator": { "id": 26591, "first_name": "Margaret Langford", "last_name": "Holland", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1205, "ror": "https://ror.org/00zm4rq24", "name": "University of New Haven", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "Home visiting programs for new mothers have a broad range of goals, including improvements in maternal and child health, reductions in child maltreatment, and improvements in child development. Over 286,000 families facing adversity are served annually by 19 evidence-based models throughout the United States, which provide support, education, and connections to other services. Before 2020, only a small portion of visits were delivered through tele home visiting (teleHV; phone or video encounters). The Coronavirus Disease-2019 (COVID-19) pandemic required rapid adoption of teleHV; by early April 2020, 99% of home visits were by teleHV. Prior to 2020, teleHV was recommended only as a partial replacement for in-person visits and only after a relationship between the home visitor and family was established, because of the importance of the therapeutic relationship. This relationship is a key element across home visiting programs, because it serves as the foundation for teaching, mentoring, and collaborating with the family. There is limited evidence regarding teleHV, although we anticipate many families will use a mix of in-person visits and teleHV after COVID-19 restrictions are lifted due to greater flexibility and other advantages. We propose a secondary data analysis to make use of this natural experiment and determine if in-person visits during the establishment of the home visitor-family relationship is associated with better outcomes than teleHV during the establishment of this relationship. We will also explore if family characteristics associated with better outcomes vary between in- person home visiting and teleHV, which will contribute to our understanding of both acceptance and effectiveness of teleHV by family characteristics. We will consider both health outcomes (maternal depressive symptoms, breastfeeding, intimate partner violence [IPV]) and process outcomes (retention, visit attendance, screening completion). We will obtain data from a large, evidence-based home visiting program, Nurse-Family Partnership (NFP). NFP has approximately 260 sites across the United States; 1000 to 1600 pregnant first- time mothers enroll per month, before their third trimester and receive regular visits (frequency varies by developmental stage: weekly to monthly) from nurses during pregnancy through the child’s second birthday. The NFP National Service Office collects data on all enrolled families both at intake and at defined time points regarding visits, screenings, and outcomes (including maternal and child health). We have previously worked with these data and are well-positioned to access and analyze them. Our estimated sample size for the primary aim is 3000 families per group. This will allow sufficient power to conduct regression analyses, controlling for family, program site, and community characteristics. This project will provide critical new knowledge about the importance of starting the home visiting relationship in person vs. through teleHV. This knowledge will help home visiting programs better utilize teleHV in the future, resulting in better outcomes for the families served in these circumstances, including reductions in health inequities.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "9514", "attributes": { "award_id": "7R03EB026171-03", "title": "Validation of an Immersive Virtual Reality Based Experiential Learning Simulator to Improve Medication Administration Safety Skills of Registered Nurses", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 24105, "first_name": "Grace", "last_name": "Peng", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-01", "end_date": "2023-06-30", "award_amount": 59783, "principal_investigator": { "id": 25221, "first_name": "Kelly", "last_name": "Rossler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1215, "ror": "", "name": "UT SOUTHWESTERN MEDICAL CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 25222, "first_name": "Ganesh", "last_name": "Sankaranarayanan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1215, "ror": "", "name": "UT SOUTHWESTERN MEDICAL CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "In 2019, the normalization, anticipation, and preparation for seasonal flu routinely occurring from October to December radically changed with the presence of the SARS-CoV-2 virus and the subsequent announcement by the World Health Organization of the novel coronavirus disease 19 (COVID-19) pandemic in March of 2020. Total cases of COVID-19 in the United States has grown to over 4 million. Research and data continue to emerge as to how COVID-19 is severely impacting infection control safety and testing practices among frontline healthcare professionals. These frontline healthcare professionals are practicing in acute and chronic healthcare facilities, working within emergency response systems, and preparing pre-licensure students within academic healthcare programs of study. In 2014, the Infectious Diseases Society, Society for Healthcare Epidemiology of America, and The Joint Commission recognized the urgency to reduce healthcare-associated infections. The original compendium of protocols remains as a 2020 Hospital National Patient Safety goal, and infection control guidelines have been updated to reflect changes in precaution measures necessitated by COVID-19. Previous educational training with lectures, cues, checklists; audits; observation with feedback; and implementation of infection control programs have sought to improve protocol compliance and knowledge on proper fit and use of personal protective equipment. However, these educational modalities and just-in-time training sessions have not been sustainable in improving practice behaviors. Additionally, these modalities do not realistically portray the use standard and transmission-based precautions urgently needed at this time, especially when this education is central to providing direct patient care such as administering medication administrations, obtaining sterile nasal specimens necessary to diagnose COVID-19, and completing bedside procedures. Currently, an increased prevalence of frontline healthcare professionals diagnosed with COVID-19 is alarming. Emerging literature describes how recycled or new forms, correct selection, donning-doffing, and acceptance of personal protective equipment are focal points for research. Moreover, the fear of this disease and significantly increased mental stress related to the potential for self-infection exists. An effective training program with cognitive and deliberate practice components to reinforce best infection control and transmission-based behaviors is a necessity identified by the Centers for Disease Control and Prevention. We propose to develop an immersive virtual reality simulator to train healthcare professionals to protect themselves when providing care to patients with COVID-19. This is significant because knowledge and skills on standard and transmission-based infection control practices can directly impact the spread and acquisition of this highly infectious disease among all healthcare professionals and can impact patient care outcomes. We propose two specific aims to demonstrate the effectiveness of the simulator. In aim 1, we will develop the simulator with capabilities to simulate all aspects of donning/doffing personal protective equipment. In aim 2, we will conduct face, content, and construct validation studies. Once the simulator is developed, it will be brought to market quickly to help the frontline workers currently caring for COVID-19 patients.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12775", "attributes": { "award_id": "7R01MH129856-02", "title": "Point-of-care prognostic modeling of PTSD risk after traumatic event exposure using digital biomarkers and clinical data from electronic health records in the emergency department setting (PREDICT)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 7721, "first_name": "Farris K.", "last_name": "Tuma", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-10", "end_date": "2027-03-31", "award_amount": 836116, "principal_investigator": { "id": 23851, "first_name": "Katharina", "last_name": "Schultebraucks", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "PROJECT SUMMARY/ ABSTRACT Currently, no accurate prognostic model of posttraumatic stress following trauma exposure for emergency department (ED) patients is available at the point-of-care without requiring clinical screening or diagnostic interviews. The proposed research is based on the rationale that the 139 million annual ED visits provide a critical window to proactively plan risk-based follow-up care at an early stage, where patients are still in contact with the health care system. While clinical interviews are still the gold standard to screen for acute stress symptoms following trauma exposure, their feasibility in clinical practice as routine screenings in the ED is severely limited given the acute care priorities in the ED. The long-term goal of the proposed research is to develop a prognostic model that is accurate, scalable, practical, and feasible with low additional burden on the highly taxed ED procedures. The overall objective is to use advanced computational methods to extract objective markers for posttraumatic stress from video and audio data to build a clinical readout at the point-of- care that will enable ED clinicians to prognosticate the risk for posttraumatic stress disorder (PTSD). Based on our preliminary data, we hypothesize that voice and speech content, head movement, pupil dilation, gaze, and facial landmark features of emotion provide probabilistic information that will allow us to identify digital biomarkers for PTSD. This hypothesis will be tested by pursuing two specific aims directed at analyzing digital biomarkers to predict 1) who is at risk to develop PTSD and 2) to combine digital biomarkers with routinely available electronic health records to predict at the point of care who will develop PTSD one month after ED discharge to plan follow-up specialty care and who is at risk for chronic PTSD. This proposed prospective longitudinal study will chart PTSD symptoms in a cohort of 350 trauma survivors. The proposed research is of high clinically significance. The prognostic model will facilitate risk-targeted early interventions for curtailing delayed treatment, assist clinicians in prioritizing treatment allocation and reduce downstream health care costs. This research project aims to deliver an objective, accurate, and reliable digital measure for patients’ well-being. Such digital biomarkers will enable more efficient discharge planning and will promote early prevention strategies. The mental besides the physical well-being of trauma-survivors admitted to the ED after a life-threatening event is of high value and is the foundation of a well-functioning, high-quality emergency care system. The SARS-CoV-2 pandemic, future disasters, or other large-scale emergencies underscore the critical need to support highly charged EDs through computational methods to better determine risks of long- term mental health care needs without disrupting the standard operating procedures of acute care.", "keywords": [ "Accident and Emergency department", "Acute", "Admission activity", "Biological", "COVID-19 pandemic", "Caring", "Cellular Phone", "Charge", "Chronic Post Traumatic Stress Disorder", "Clinical", "Clinical Data", "Clinical assessments", "Cognitive Therapy", "Computer Vision Systems", "Computing Methodologies", "Consumption", "Data", "Devices", "Diagnosis", "Diagnostic", "Digital biomarker", "Disasters", "Discharge Plannings", "Early Intervention", "Early treatment", "Effectiveness", "Electronic Health Record", "Emergency Care", "Emergency Department Physician", "Emergency Department patient", "Emergency Situation", "Emergency department visit", "Emergency response", "Emotions", "Event", "Face", "Foundations", "Future", "Goals", "Head Movements", "Health Care Costs", "Healthcare Systems", "Hospitals", "Intervention", "Interview", "Life", "Measures", "Medicine", "Mental Depression", "Mental Health", "Mental Health Services", "Mission", "Modality", "Morbidity - disease rate", "Mydriasis", "National Institute of Mental Health", "Natural Language Processing", "Nature", "Participant", "Patient Admission", "Patient Care", "Patient Self-Report", "Patients", "Personal Satisfaction", "Phenotype", "Physiological", "Post-Traumatic Stress Disorders", "Predictive Value", "Prevention", "Prevention strategy", "Privatization", "Procedures", "Prognosis", "Proxy", "Psyche structure", "Psychometrics", "Publishing", "Reporting", "Research", "Research Project Grants", "Risk", "Severities", "Speech", "Survivors", "Symptoms", "Tablets", "Taxes", "Testing", "Time", "Training", "Trauma", "Triage", "Video Recording", "Videotape", "Voice", "Work", "acute care", "acute stress", "biological adaptation to stress", "care systems", "clinical practice", "clinically significant", "cohort", "cost", "cost effective", "deep learning", "design", "digital", "digital measure", "disorder risk", "electronic health data", "electronic health information", "experience", "follow-up", "gaze", "handheld mobile device", "health application", "high risk population", "improved", "instrument", "longitudinal prospective study", "medical specialties", "multimodality", "neural", "novel", "point of care", "post-traumatic stress", "predictive marker", "predictive modeling", "professional atmosphere", "prognostic", "prognostic model", "prognostic performance", "prognostic value", "prognostication", "psychologic", "response" ], "approved": true } }, { "type": "Grant", "id": "14736", "attributes": { "award_id": "7R01MH129354-02", "title": "Prospective intergenerational mixed-methods investigation of the short- and long-term impact of COVID-19 on adolescent mental, social, and behavioral health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 8692, "first_name": "Ashley", "last_name": "Smith", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-02-01", "end_date": "2027-11-30", "award_amount": 736560, "principal_investigator": { "id": 26770, "first_name": "Jeff R", "last_name": "Temple", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 788, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "To better understand the short- and long-term impact of the COVID-19 pandemic on youth mental health and development, we will leverage our existing randomized controlled trial of a school-based healthy relationships program. In 2018, we randomized 24 Texas middle schools in disadvantaged communities in which students (n=2865; Mean age = 12.7; 50% female; 36% Black/African American, 26% Latinx; 14% Asian) received either standard health curriculum (n=12 control schools) or Fourth R (n=12 intervention schools). Participants completed baseline and three annual comprehensive follow-up assessments of their mental (e.g., depression, anxiety, hostility), social (e.g., living situation, socio-economic status, school climate, stress), and behavioral (e.g., dating violence, substance use, sexual behavior, (cyber)bullying, coping strategies) health. This longitudinal data, with relevant measures established prior to the COVID-19 pandemic and resulting stay-at- home orders, provides a powerful opportunity to understand the long-term impact of this global crisis on youth development, mental health, risk behaviors, and academic achievement and explore risk and protective factors moderating this impact. Thus, we will 1) administer an additional four years of annual follow-up surveys, beginning in the 12th grade and follow students until they are, on average, 21 years of age; 2) recruit and assess parents of participants; 3) augment our already extensive student-level data with comprehensive pandemic-related measures, as well as school-, neighborhood-, and environmental-level factors that may moderate impact; and 4) conduct qualitative interviews of educators (n=24), students (n=24), and parents (n=24) to obtain a richer understanding of factors that mitigated or exacerbated the impact of COVID-19 and resulting disruptions to school, family, mental health, and development. Specific aims are to 1) Determine the short- and long-term impact of the COVID-19 pandemic on adolescents' mental, behavioral, and social health, as well as their academic performance and career potential; 2) Examine the moderating impact of family and income stability, parent-child relationships, parent mental health, equity (access to education, digital divide), learning model (in-person, online, hybrid), school disruptions, and school and neighborhood climate on COVID- 19 impacts for youth; 3) Investigate whether and how pandemic-related stressors (individual/family COVID impacts of job interruption, food access, media consumption, and vaccine uptake) are linked to short- and long- term health behaviors and outcomes; and 4) Evaluate the secondary benefits of Fourth R in mitigating the negative impact of the COVID-19 pandemic. Given that the intervention targets mental wellbeing, conflict resolution, coping, and help-seeking, we hypothesize that students exposed to the intervention will evidence improved mental, social, and behavioral health relative to their counterparts in control schools. Our study will provide a rigorous and comprehensive understanding of the impact of COVID-19 – quantitatively by leveraging data from an ongoing cohort and contextually through qualitative investigation.", "keywords": [ "21 year old", "Academic achievement", "Adolescent", "African American", "Age", "Anxiety", "Asian", "Award", "Behavioral", "Black race", "COVID-19 impact", "COVID-19 pandemic", "COVID-19 pandemic effects", "Climate", "Communities", "Conflict (Psychology)", "Coping Skills", "Data", "Development", "Dropout", "Economics", "Education", "Educational Curriculum", "Educational Status", "Equity", "Event", "Exposure to", "Family", "Female", "Food Access", "Future", "Health", "Health behavior", "Health behavior and outcomes", "Hostility", "Housing", "Hybrids", "Income", "Individual", "Instruction", "Interruption", "Intervention", "Interview", "Investigation", "Job loss", "Latinx", "Learning", "Link", "Longitudinal Studies", "Measurement", "Measures", "Mental Depression", "Mental Health", "Methods", "Modeling", "National Institute of Mental Health", "Natural Disasters", "Neighborhoods", "Occupations", "Outcome", "Parent-Child Relations", "Parents", "Participant", "Performance", "Persons", "Prevention program", "Psyche structure", "Randomized", "Randomized Controlled Trials", "Risk", "Risk Behaviors", "Risk Factors", "Schools", "Sex Behavior", "Social isolation", "Socioeconomic Status", "Source", "Stress", "Students", "Surveys", "Texas", "War", "Well in self", "Youth", "adolescent health", "behavioral health", "career", "cohort", "college", "conflict resolution", "coping", "cyberbullying", "dating violence", "design", "digital divide", "economic disparity", "educational atmosphere", "experience", "follow up assessment", "follow-up", "future pandemic", "help-seeking behavior", "housing instability", "improved", "intergenerational", "intervention program", "junior high school", "long term consequences of COVID-19", "mass shooting", "media use", "mental development", "neighborhood disadvantage", "neighborhood safety", "pandemic disease", "pandemic stressor", "parental role", "partner violence", "post-pandemic", "programs", "prospective", "protective factors", "racial disparity", "recruit", "risk sharing", "school disruption", "social", "stay-at-home order", "substance misuse", "substance use", "suicidal", "teacher", "twelfth grade", "vaccine acceptance" ], "approved": true } } ], "meta": { "pagination": { "page": 5, "pages": 1442, "count": 14420 } } }