Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=5&sort=-approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=6&sort=-approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-approved" }, "data": [ { "type": "Grant", "id": "6912", "attributes": { "award_id": "1IK2RX003546-01A2", "title": "Enhanced Home-Based Exercise Therapy for Peripheral Arterial Disease through Mobile Health and Remote Monitoring", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2026-09-30", "award_amount": null, "principal_investigator": { "id": 22750, "first_name": "Arash", "last_name": "Harzand", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "An estimated 8.5 million Americans (or 7% of US adults) and nearly 10% of veterans are estimated to have peripheral arterial disease (PAD). Significantly debilitating and negatively impacting quality of life, the primary symptom of PAD is claudication (reproducible leg pain with ambulation) that leads to impaired mobility, loss of functional independence, and a heightened risk for amputation. Veterans are at an increased risk of developing symptomatic PAD due to their disproportionately high rates of PAD risk factors such as diabetes, smoking, and hypertension, the most prominent PAD risk factors. Supervised exercise therapy is proven to decrease claudication and enhance mobility in PAD; however, fewer than 25% of eligible patients enroll. Participation in this facility-based program requires travel to a rehabilitation center 3 times per week for 12-weeks, which can be burdensome and costly for Veterans, many of whom live in rural areas and on fixed incomes. There is, therefore, a need to develop a convenient and effective alternative exercise rehabilitation program for Veterans with PAD, particularly in light of safety considerations now associated with this population’s travel to group facilities in the current COVID pandemic. A promising approach to increase access to exercise rehabilitation for PAD is remote, home-based exercise therapy (HBET). Our group has successfully delivered a smartphone-enabled HBET program to Veterans with coronary artery disease with a 3-fold increase in participation and high satisfaction (80%). To this end, we are committed to utilizing technology innovations to implement HBET for Veterans with PAD successfully. HBET programs combine self-led walking exercises with health coaching and exercise tracking with a wearable activity monitor. Adapting HBET to PAD is difficult, however, due to the added complexity of an exercise prescription that requires the patient to walk until they experience near-maximal leg pain. Even with active coaching, successfully implementing HBET for PAD with long-term adherence has been difficult in the past. Our goal, therefore, is to leverage newer mobile health (mHealth) tools to adapt HBET for PAD. We propose to test our technology-enhanced approach for HBET by partnering with a successful VA lifestyle program, MOVE!, which has demonstrated success in achieving sustained weight loss and reduced diabetes onset through lifestyle modification. As increased physical activity is a core element of MOVE!, participation may help increase adherence with HBET for PAD. Our newly proposed program, Smart MOVE!, will be a multi-component program featuring a tailored version of MOVE! and a novel mHealth device called the LifeQ to improve convenience, access, and adherence to HBET for PAD. Aim 1 (Years 1-2): Identify barriers and facilitators to MOVE! participation among Veterans with PAD. Aim 2 (Years 1-2): Evaluate the feasibility of the LifeQ device to monitor exercise during HBET Aim 3 (Years 2-5): Determine the feasibility of proceeding with Smart MOVE! through a pilot randomized trial. As a VA physician actively treating Veterans with PAD, I have seen first-hand the challenges they face in accessing guideline-directed treatments such as supervised exercise. This study will lay the groundwork and provide evidence to proceed with Smart MOVE!, a much-needed patient-centered exercise rehabilitation program for PAD. Additionally, the proposed training plan will support my progress towards becoming an independent VA rehabilitation clinician-scientist focused on improving care quality and treatment outcomes for Veterans with PAD.", "keywords": [ "Accelerometer", "Activities of Daily Living", "Adherence", "Adult", "Affect", "American", "Amputation", "Behavioral", "Body Weight decreased", "COVID-19 pandemic", "Cardiac rehabilitation", "Cellular Phone", "Clinical", "Complex", "Coronary Arteriosclerosis", "Data", "Devices", "Diabetes Mellitus", "Elements", "Enhancement Technology", "Enrollment", "Exercise", "Exercise Therapy", "Face", "Goals", "Gold", "Guidelines", "Health", "Health Technology", "Home", "Hospitals", "Hypertension", "Impairment", "Income", "Indirect Calorimetry", "Intervention", "Interview", "Leadership", "Leg", "Life Style", "Life Style Modification", "Light", "Measurement", "Monitor", "Myocardial Infarction", "Oxygen Consumption", "Pain in lower limb", "Patient Education", "Patients", "Peripheral arterial disease", "Physical activity", "Physicians", "Population", "Provider", "Quality of Care", "Quality of life", "Rehabilitation Centers", "Rehabilitation therapy", "Reproducibility", "Resolution", "Risk", "Risk Factors", "Safety", "Scientist", "Smoking", "Stroke", "Structure", "Supervision", "Symptoms", "Technology", "Testing", "Time", "Training", "Travel", "Treatment outcome", "Vertebral column", "Veterans", "Walking", "aged", "base", "behavior change", "claudication", "cost", "design", "evidence base", "exercise prescription", "exercise program", "exercise regimen", "exercise rehabilitation", "experience", "functional independence", "functional loss", "functional outcomes", "high risk", "improved", "improved mobility", "informant", "innovation", "mHealth", "mortality risk", "multi-component intervention", "novel", "patient oriented", "primary outcome", "programs", "randomized trial", "remote monitoring", "rural area", "satisfaction", "success", "symptomatic improvement", "tool" ], "approved": true } }, { "type": "Grant", "id": "4096", "attributes": { "award_id": "1607069", "title": "2016 Cellular & Molecular Fungal Biology GRC, Plymouth, New Hampshire, June 19-24, 2016", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [ { "id": 13758, "first_name": "Michael", "last_name": "Mishkind", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-07-01", "end_date": "2017-06-30", "award_amount": 15000, "principal_investigator": { "id": 13759, "first_name": "Amy", "last_name": "Gladfelter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will facilitate the attendance and participation of early career scientists in the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 19-24, 2016. The goal of the conference is to disseminate information about fungal biology among an interdisciplinary group of researchers, and to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are essential parts of the terrestrial nutrient cycle, play a central role in the development of biofuels, and produce many critically important chemicals. These diverse applications of fungi require the interdisciplinary acquisition and application of fundamental fungal biology. This project will support the convergence and exchange of new findings amongst an interdisciplinary group of scientists dedicated to the study of fungi. \n\nThe intellectual merit of the project is rooted in the meeting's highly interdisciplinary and interactive format. The meeting will feature topics that integrate multiple time and space scales for different questions in fungal biology to promote interactions amongst researchers with diverse perspectives within the community. There is a specific emphasis on integrating mathematical modeling and biophysics as a new addition to this meeting and an entire session is dedicated to the interface of fungal biology with the physical sciences. The meeting enables cross-fertilization of ideas, from cell biology to evolution, that occurs in and outside of the sessions and especially between junior and senior scientists. Young investigators emphasize from previous meetings how interactive the conference is and how responsive it is to the presentation of their work.\n\nThis conference has broad impacts on training and is dedicated to extending the research community by emphasizing women and members of underrepresented groups in inviting speakers. The current invited speakers are approximately 50% women, including several Latinas. The small size of the meeting and the emphasis on discussion (40% of meeting time is dedicated to discussions) encourages active participation. Poster sessions are featured without competing events to focus attention on the most junior scientists, who often have the newest data. The GRC on Cell and Molecular Fungal Biology also is dedicated to research that applies basic knowledge to socially important questions involving filamentous fungi, particularly mutualisms with plants (mycorrhizae), parasitism with plants (plant pathology) and animals (animal pathology), and industrial mycology (enzyme production). The interactions among researchers focused on both basic and socially important research speeds research aimed at solving societal problems caused by or that can be improved by fungi.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "13568", "attributes": { "award_id": "2144751", "title": "CAREER: Efficient, Dynamic, Robust, and On-Device Continual Deep Learning with Non-Volatile Memory based In-Memory Computing System", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)", "Software & Hardware Foundation" ], "program_reference_codes": [], "program_officials": [ { "id": 977, "first_name": "Sankar", "last_name": "Basu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-01-15", "end_date": null, "award_amount": 500000, "principal_investigator": { "id": 8714, "first_name": "Deliang", "last_name": "Fan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 173, "ror": "", "name": "The University of Central Florida Board of Trustees", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 147, "ror": "https://ror.org/03efmqc40", "name": "Arizona State University", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).<br/><br/>Over past decades, there have existed grand challenges in developing high performance and energy-efficient computing solutions for big-data processing. Meanwhile, owing to the boom in artificial intelligence (AI), especially Deep Neural Networks (DNNs), such big-data processing requires efficient, intelligent, fast, dynamic, robust, and on-device adaptive cognitive computing. However, those requirements are not sufficiently satisfied by existing computing solutions due to the well-known power wall in silicon-based semiconductor devices, the memory wall in traditional Von-Neuman computing architectures, and computation-/memory-intensive DNN computing algorithms. This project aims to foster a systematic breakthrough in developing AI-in-Memory computing systems, through collaboratively developing ahybrid in-memory computing (IMC) hardware platform integrating the benefits of emerging non-volatile resistive memory (RRAM) and Static Random Access Memory (SRAM) technologies, as well as incorporating IMC-aware deep-learning algorithm innovations. The overarching goal of this project is to design, implement, and experimentally validate a new hybrid in-memory computing system that is collaboratively optimized for energy efficiency, inference accuracy, spatiotemporal dynamics, robustness, and on-device learning, which will greatly advance AI-based big-data processing fields such as computer vision, autonomous driving, robotics, etc. The research will also be extended into an educational platform, providing a user-friendly learning framework, and will serve the educational objectives for K-12 students, undergraduate, graduate, and under-represented students.<br/><br/>This project will advance knowledge and produce scientific principles and tools for a new paradigm of AI-in-Memory computing featuring significant improvements in energy efficiency, speed, dynamics, robustness, and on-device learning capability. This cross-layer project spans from device, circuit, and architecture to DNN algorithm exploration. First, a hybrid RRAM-SRAM based in-memory computing chip will be designed, optimized, and fabricated. Second, based on this new computing platform, the on-device spatiotemporal dynamic neural network structure will be developed to provide an enhanced run-time computing profile (latency, resource allocation, working load, power budget, etc.), as well as improve the robustness of the system against hardware intrinsic and adversarial noise injection. Then, efficient on-device learning methodologies with the developed computing platform will be investigated. In the last thrust, an end-to-end DNN training, optimization, mapping, and evaluation CAD tool will be developed that integrates the developed hardware platform and algorithm innovations, for optimizing the software and hardware co-designs to achieve the user-defined multi-objectives in latency, energy efficiency, dynamics, accuracy, robustness, on-device adaption, etc.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6144", "attributes": { "award_id": "3R01MD012421-03S1", "title": "Influence of patient-centered HIV care on retention and viral suppression disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 20877, "first_name": "Richard", "last_name": "Berzon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-01-29", "end_date": "2023-11-30", "award_amount": 268162, "principal_investigator": { "id": 20878, "first_name": "MARY JO JO", "last_name": "TREPKA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 207, "ror": "https://ror.org/02gz6gg07", "name": "Florida International University", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "People with human immunodeficiency virus (HIV) are at increased risk of COVID-19 complications due to underlying immunosuppression and comorbidities and thus can significantly benefit from COVID-19 vaccination. People with HIV (PWH) are also more likely to belong to racial/ethnic minorities that have been disproportionately burdened by the COVID-19 pandemic and are currently underrepresented among vaccinated individuals. The objective of this study is to identify points of intervention to increase COVID-19 vaccine uptake among African American, Hispanic, and Haitian PWH. To achieve this objective, we will conduct a mixed methods study involving a sample of 129 Hispanics, 116 African Americans and 53 Haitians with HIV who were previously interviewed from October 2020 to January 2021 about the effect of the COVID- 19 pandemic on their health and wellbeing and their HIV care (Wave 1). The current supplement (Wave 2) will extend the previous study by determining COVID-19 vaccine uptake and factors associated with vaccine uptake. The survey questions will collect quantitative data about factors associated with vaccination using both the Health Belief Model (e.g., perceived susceptibility to COVID-19, perceived severity of COVID-19, perceived barriers and benefits of COVID-19 vaccination, and cues to action) and the Social Ecological Model (i.e., potential intrapersonal, interpersonal, and community/institutional-level factors associated with COVID-19 vaccine uptake). Data from the survey will also be used to identify the extent to which COVID-19 vaccination improves psychosocial (e.g., COVID-19 related worry) and socioeconomic (e.g., reduced income) stressors. Furthermore, we will conduct exploratory analyses to assess the association between vaccination and retention in HIV care and viral suppression. Subsequently, we will ask a sample of vaccinated and unvaccinated survey respondents to participate in semi-structured in-depth interviews to clarify quantitative findings and identify points of intervention. Findings from this study will guide vaccination promotion messages for racial/ethnic minorities with HIV, guide vaccination delivery methods (e.g., vaccination in HIV care settings), and elucidate the potential role of COVID-19 vaccination in improving the health and wellbeing of people with HIV.", "keywords": [ "African American", "Anxiety", "COVID-19", "COVID-19 mortality", "COVID-19 pandemic", "COVID-19 severity", "COVID-19 vaccination", "COVID-19 vaccine", "Caring", "Case Manager", "Client", "Communities", "Cross-Sectional Studies", "Cues", "Data", "Depressed mood", "Feeling", "HIV", "Haitian", "Health", "Hispanics", "Hour", "Household", "Immunosuppression", "Income", "Individual", "Intervention", "Interview", "Loneliness", "Medical", "Methods", "Minority Groups", "Modeling", "Not Hispanic or Latino", "Occupations", "Participant", "Personal Satisfaction", "Population", "Predisposition", "Recommendation", "Reporting", "Respondent", "Risk", "Role", "Sampling", "Social Network", "Structure", "Surveys", "Telephone", "Vaccinated", "Vaccination", "Viral", "Virus Diseases", "anxious", "care providers", "comorbidity", "ethnic minority population", "follow-up", "health belief", "improved", "pandemic disease", "patient oriented", "programs", "psychosocial", "racial and ethnic", "severe COVID-19", "social", "social norm", "socioeconomics", "stressor", "vaccine acceptance" ], "approved": true } }, { "type": "Grant", "id": "8704", "attributes": { "award_id": "1U01HL158759-01", "title": "The effect of SARS-CoV-2 on the susceptibility of respiratory outcomes in a Puerto Rican Birth Cohort", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22703, "first_name": "Michelle M", "last_name": "Freemer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-20", "end_date": "2022-07-31", "award_amount": 646280, "principal_investigator": { "id": 24488, "first_name": "LUISA N", "last_name": "BORRELL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24489, "first_name": "Esteban Gonzalez", "last_name": "Burchard", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 24490, "first_name": "JOSE", "last_name": "RODRIGUEZ-SANTANA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. The lack of diagnostic tests and current public health policies limit our knowledge of the true prevalence of SARS- CoV-2. Infection with SARS-CoV-2 results in production of anti-viral antibodies in infected hosts, yet it is currently unknown whether these antibody responses are protective against subsequent infection. Survivors of the 2003 SARS coronavirus outbreak had reduced lung function and quality of life, and more frequent viral respiratory illnesses. The latter are associated with increased risk for childhood wheeze and asthma, the most common chronic and disparate disease among children. Data also indicate that there are significant racial/ethnic disparities in COVID-19 outcomes. Disparities in risk of viral exposure, susceptibility to severe disease, and access to health care may interact to exacerbate existing health inequalities. Pregnancy provides a natural mechanism by which to examine the protective potential of passive immunity. Maternal IgG is actively transported across the placenta and in the absence of postnatal exposure wane to undetectable levels in the neonate over the first year of life. Furthermore, IgA is passed from mother to child through breastmilk. Our multidisciplinary team will study a unique cohort of Puerto Rican mothers and their infants prospectively following the infants through their first five years of life collecting maternal breastmilk, maternal and neonatal cord blood, and neonatal/infant nasal epithelium swabs at birth, during respiratory illness, and at yearly clinical evaluations. We will determine prenatal exposure to SARS-CoV-2 as measured from maternal and infant cord blood at time of birth and investigate the effect this virus has on the susceptibility of respiratory disease in children. We will screen all pre/postpartum mothers with a PCR assay and qualitative immunoassay to detect SARS-CoV-2 infection. Among all seropositive mothers, we will collect repeated breast milk samples at 5 and 14 days and serial newborn blood spot samples at birth, 1, 3, 6 months, and yearly for 5 years. We will measure IgA, IgG, and IgM in maternal breastmilk and blood samples, and IgG in infant serum. We will examine (Aim 1) the passive transfer of SARS-CoV-2 immunity from seropositive mothers to their neonates, (Aim 2) whether early life SARS- CoV-2 infection severity and other clinical sequelae is modified by altered childhood immunophenotypes and host genetics, and (Aim 3) how socio-environmental factors affect maternal and infant exposure to COVID-19 and further affect the development of childhood asthma. We hypothesize that pregnant women infected with SARS-CoV-2 produce neutralizing antibodies, which protect their newborns from COVID-19 disease. In contrast, infants who contract SARS-CoV-2 after birth are at increased risk for later respiratory disease including asthma and other clinical sequelae. We further postulate that these associations are modified by host genetic and socio- environmental factors. To our knowledge, there are no other groups within or outside the U.S. with the population needed and track record to perform these analyses.", "keywords": [ "2019-nCoV", "21 year old", "5 year old", "Active Biological Transport", "Address", "Admixture", "Adult Respiratory Distress Syndrome", "Affect", "Antibody Response", "Asthma", "Biological", "Biological Assay", "Birth", "Blood", "Blood specimen", "Businesses", "COVID-19", "COVID-19 detection", "COVID-19 morbidity", "COVID-19 mortality", "COVID-19 pandemic", "COVID-19 severity", "Cessation of life", "Child", "Childhood", "Childhood Asthma", "Chronic", "Chronic Disease", "Clinic Visits", "Clinical", "Cohort Studies", "Contracts", "Data", "Development", "Diagnostic tests", "Disease", "Disease Outbreaks", "Ethnic Origin", "Exposure to", "Future", "Genetic", "Genetic Variation", "Health Policy", "Health Services Accessibility", "Human Milk", "Immune", "Immunity", "Immunoassay", "Immunoglobulin A", "Immunoglobulin G", "Immunoglobulin M", "Immunologics", "Immunophenotyping", "Individual", "Infant", "Infection", "Knowledge", "Latino", "Life", "Link", "Lung diseases", "Maternal Exposure", "Measures", "Metagenomics", "Minority", "Mothers", "Multisystem Inflammatory Syndrome in Children", "Nasal Epithelium", "Neonatal", "New York City", "Newborn Infant", "Outcome", "Participant", "Passive Immunity", "Peripheral Blood Mononuclear Cell", "Placenta", "Play", "Population", "Positioning Attribute", "Postpartum Period", "Predisposition", "Pregnancy", "Pregnant Women", "Prevalence", "Production", "Public Health", "Puerto Rican", "Puerto Rico", "Quality of life", "Race", "Recruitment Activity", "Risk", "Role", "SARS coronavirus", "SARS-CoV-2 antibody", "SARS-CoV-2 exposure", "SARS-CoV-2 immunity", "SARS-CoV-2 infection", "SARS-CoV-2 positive", "Sampling", "Schools", "Seasonal Variations", "Serology", "Serum", "Severities", "Social Environment", "Socioeconomic Status", "Spottings", "Survivors", "Swab", "Testing", "Time", "Umbilical Cord Blood", "Viral", "Viral Antibodies", "Viral Respiratory Tract Infection", "Virus", "Wheezing", "Woman", "antibody transfer", "base", "clinical risk", "cohort", "design", "disease disparity", "epidemiology study", "family structure", "genome-wide", "health care availability", "health inequalities", "high risk", "infant infection", "minority children", "mortality", "multidisciplinary", "neonatal immunity", "neonate", "neutralizing antibody", "pandemic disease", "peripheral blood", "postnatal", "pregnant", "prenatal exposure", "prospective", "pulmonary function", "racial and ethnic" ], "approved": true } }, { "type": "Grant", "id": "3840", "attributes": { "award_id": "1707069", "title": "WERF: Determining the fate and major removal mechanisms of microplastics in water and resource recovery facilities", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Engineering (ENG)", "EnvE-Environmental Engineering" ], "program_reference_codes": [], "program_officials": [ { "id": 12614, "first_name": "Mamadou", "last_name": "Diallo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-08-01", "end_date": "2021-07-31", "award_amount": 304892, "principal_investigator": { "id": 12616, "first_name": "Belinda", "last_name": "Sturm", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 415, "ror": "", "name": "University of Kansas Center for Research Inc", "address": "", "city": "", "state": "KS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 12615, "first_name": "Edward", "last_name": "Peltier", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 415, "ror": "", "name": "University of Kansas Center for Research Inc", "address": "", "city": "", "state": "KS", "zip": "", "country": "United States", "approved": true }, "abstract": "Proposal: 1707069\nPI: Belinda Sturm\n\nThe focus of this project is the fate of microplastics (plastics < 5mm) in the liquid and biosolids discharged from water resource and recovery facilities (WRRFs). Microplastics are typically entrained within activated sludge and ultimately released to the environment through biosolids. The detrimental effects of plastics on marine vertebrates is well-documented and a major environmental concern. In this project the transport pathways for plastics will be identified. The results of this study will help reduce harmful marine ecosystem impacts. The PIs will engage municipalities through a full-scale sampling campaign and will disseminate the data in a web-based database that is publically accessible. They will continue to collaborate with high school teachers to refine teaching modules dealing with topics focused on microplastics and emerging contaminants.\n\nMicroplastics are likely to be removed when they are adsorbed or entrained within the activated sludge floc structure. The main hypothesis is that the sludge structure and extracellular polymeric substances (EPS) content are controlling variables to microplastic removal. In particular, the assumption is that microbial aggregates with high surface areas and high EPS content can capture more microplastics. To test this hypothesis the PIs will conduct a survey of select WRRFs with different primary and secondary treatment processes. To further quantify microplastics capture efficiencies, the PIs will determine the effect of EPS on microplastic adsorption and retention efficiency within lab-scale and pilot-scale reactors and compare conventional and aerobic granular sludge processes for microplastic adsorption. The activated sludge process, and particularly gravity sedimentation, was not designed to remove low density microplastic particles. Microplastics are likely to be removed when they are adsorbed or entrained within the activated sludge floc structure. As microplastic loads to WRRFs increase, it is important to study the effect of niche separation of microplastic-associated microorganisms on activated sludge process performance. One outcome of the research will be a better understanding the fate of microplastics in WRRFs. Results of this project will provide a framework for comprehensive management of microplastics contamination in WRRFs.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5120", "attributes": { "award_id": "1010204", "title": "CNH/EID: The Vector Mosquito Aedes aegypti at the Margins: Sensitivity of a Coupled Natural and Human System to Climate Change", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "DYN COUPLED NATURAL-HUMAN" ], "program_reference_codes": [], "program_officials": [ { "id": 18242, "first_name": "Sarah", "last_name": "Ruth", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2010-10-01", "end_date": "2014-09-30", "award_amount": 1235153, "principal_investigator": { "id": 18246, "first_name": "Andrew", "last_name": "Monaghan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 275, "ror": "", "name": "University Corporation For Atmospheric Res", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18243, "first_name": "Mary H", "last_name": "Hayden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18244, "first_name": "Lars M", "last_name": "Eisen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18245, "first_name": "Luca Delle", "last_name": "Monache", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 275, "ror": "", "name": "University Corporation For Atmospheric Res", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will explore the ecology of Aedes (Ae.) aegypti, the mosquito that transmits dengue, yellow fever and chikungunya. We hypothesize that the combined effects of climate variability and changes made by humans to their local environment can influence key aspects of both mosquito ecology and human behavior. Studying this system as a whole will improve our ability to predict risks of mosquito vector and dengue virus exposure and the possible impacts of future climate change. \n\nDengue viruses circulate between mosquitoes and humans, causing an estimated 100 million human dengue infections annually. In the last decade, the Americas have experienced a dramatic increase in severe cases (dengue hemorrhagic fever), with devastating public health consequences. As neither vaccines nor therapeutics are yet available, mosquito control is the main option for preventing and controlling dengue outbreaks. Efforts in this area have been hindered by a poor understanding of the dengue virus transmission system at the interface between its natural and human components. Of particular concern is the potential for dengue fever to expand into areas that are presently outside transmission zones but may become vulnerable under scenarios of future climate change. For example, this potential expansion poses a risk to the ~19 million people in and near Mexico City, a high altitude \"island\" currently free of dengue but surrounded by dengue virus transmission at lower altitudes. \n\nSpecific aims of the project are to: (1) determine how weather/climate factors are related to the presence and abundance of disease-carrying mosquitoes, especially by serving as barriers to mosquitoes becoming established in an area; (2) use these results in high-resolution atmospheric models to develop a predictive model for future mosquito range expansion; (3) determine which aspects of human behavior and attributes of man-made environments are most closely related to Ae. aegypti presence and abundance; (4) employ state-of-the-science data assimilation procedures to validate, refine, and define uncertainty in this modeling framework. Key aspects of this coupled natural and human system will be studied along an altitudinal transect in Mexico, ranging from coastal, low-elevation environments with well established vector mosquito populations and intense dengue virus transmission to high-elevation, mountainous areas which currently are free of the mosquito vector and local virus transmission. The team of experts from Mexico and the United States includes climatologists, vector ecologists, modelers and medical anthropologists.\n\nThe project will contribute essential insights into the ongoing debate about climate change and infectious disease relationships, extending beyond the explicit vector ecology and geographic boundaries of this study. The work will provide quantitative knowledge that can be used to develop novel strategies to control Ae. aegypti in the face of future threats to system resilience. Further, it will provide training for a postdoctoral fellow in climate modeling and spatial risk modeling at both Colorado State University and the National Center for Atmospheric Research and involvement and in situ training of university and secondary school students in data collection. Through \"participatory epidemiology\", local community members will learn how to use environmental observation and data collection as a means of community empowerment.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12032", "attributes": { "award_id": "5R01TW012397-02", "title": "Sweekar - Multi-level intersectional stigma reduction to increase HIV testing and care engagement among trans women in Nepal", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)", "Fogarty International Center (FIC)" ], "program_reference_codes": [], "program_officials": [ { "id": 8125, "first_name": "GEETHA PARTHASARATHY", "last_name": "Bansal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2025-06-30", "award_amount": 163100, "principal_investigator": { "id": 25559, "first_name": "Erin", "last_name": "Meek", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1615, "ror": "https://ror.org/03t7m8092", "name": "Public Health Foundation Enterprises", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Trans women in low- and middle- income countries make up the largest proportion of trans women around the globe but are underserved in the response to HIV. Nepal is a lower income country in South Asia where trans women are a key population highly impacted by HIV. In 2019/20, we conducted an exploratory study with trans women finding that 11.3% were living with HIV, and only 70% were engaged in HIV care and virally suppressed. Discrimination resulting in anticipated HIV stigma and experienced anti-trans stigma was a main driver of low HIV testing and HIV care engagement. HIV risk was further exacerbated by anti-trans stigma resulting in barriers to education, employment, social support and empowerment. For example, because most trans women faced discrimination in job seeking, the majority of participants in our exploratory work did sex work for income and had high rates of condomless sex and many sexual partners. HIV Interventions for trans women are needed that will have sustained impact by addressing stigma at many levels that present barriers to health and wellness. However, few HIV prevention and treatment interventions tackle intersectional stigma, and even fewer are developed for low- and middle-income country settings. Building on evidence from our exploratory study, we propose to test a multi-level, HIV serostatus-neutral stigma reduction intervention called Sweekar, or acceptance in Nepali. The primary intervention outcomes are HIV testing and HIV care engagement. To increase HIV testing by addressing anticipated stigma, the individual level intervention component is a tailored HIV self-testing intervention. To increase ART adherence by addressing anticipated and experiences stigma, the systems level intervention component is HIV treatment home delivery. To address stigma at the community level, we will conduct a contact intervention11 informed by Photovoice12 to reduce experienced and internalized stigma. Photovoice will be used to inform content and delivery of a social media campaign to reduce anti-trans in Nepali society, with benefits for increasing social support and empowerment among trans women in Nepal, which will help mitigate internalized stigma. Our approach is community-driven and non-randomized to maximize benefit for trans women in immediate need of intervention, which is an essential practice to reduce health disparities. Feasibility is high as the US and Nepali researchers have forged a strong collaboration over the course of more than a decade working together to serve trans women in research and services. Furthermore, Covid-19 has created new opportunities for innovations HIV care and prevention that will be leveraged in Sweekar. If Sweekar is successful, we will immediately use the outcome data and lessons learned to develop multi-site R01 proposal to test the intervention at scale throughout Nepal and in partnership with our Nepali research and implementation team.", "keywords": [ "AIDS prevention", "Address", "Adherence", "Alcohol consumption", "Asia", "Attitude", "COVID-19", "Caring", "Categories", "Collaborations", "Communities", "Data", "Diamond", "Discrimination", "Distress", "Economics", "Education", "Employment", "Failure", "Frequencies", "Funding", "Gender", "General Population", "Geography", "HIV", "HIV risk", "HIV-2", "Health", "Home", "Human immunodeficiency virus test", "Income", "Individual", "Interruption", "Intervention", "Knowledge", "Learning", "Media Campaign", "Modeling", "Nepal", "Nongovernmental Organizations", "Occupations", "Outcome", "Participant", "Persons", "Pharmaceutical Preparations", "Policies", "Population", "Population Study", "Positioning Attribute", "Prevalence", "Prevention", "Prevention program", "Psyche structure", "Reduce health disparities", "Research", "Research Personnel", "Services", "Sexual Partners", "Sexual and Gender Minorities", "Site", "Social support", "Societies", "Stigmatization", "System", "Testing", "United States National Institutes of Health", "Unsafe Sex", "Violence", "Viral", "Viral Load result", "Work", "care delivery", "design", "empowerment", "evidence base", "experience", "forging", "improved", "innovation", "internalized stigma", "low and middle-income countries", "low income country", "marginalized population", "physical assault", "prevent", "prevention service", "response", "self testing", "sex", "sexual assault", "sexual minority group", "sexual risk behavior", "social media", "social stigma", "transgender women", "uptake", "verbal" ], "approved": true } }, { "type": "Grant", "id": "9216", "attributes": { "award_id": "3R01EB027202-01A1S1", "title": "Directed evolution of polymerases that can read and write extremely long sequences", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 24310, "first_name": "David", "last_name": "Rampulla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-01", "end_date": "2022-08-31", "award_amount": 182969, "principal_investigator": { "id": 4640, "first_name": "Andrew D", "last_name": "Ellington", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 156, "ror": "", "name": "University of Texas at Austin", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 972, "ror": "", "name": "UNIVERSITY OF TEXAS AT AUSTIN", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Supplemental Project Summary (derived from the original, changes underlined) Advances in synthetic biology have accelerated to the point where the synthesis of entire genomes is now possible. However, the technologies for these feats are painstaking, and the production of a new chromosome or genome requires multiple years of effort, working from small fragments to ever larger assemblies. The speed (and ultimately scale) of large fragment assembly would be greatly improved if it were possible to routinely amplify very long stretches of DNA (> 100 kb) in vitro. The methods developed in the execution of this proposal should also prove extremely useful for greatly improved reagents for molecular diagnostics for SARS-CoV-2. To that end, this proposal is focused on the further development of a novel directed evolution method known as Compartmentalized Self-Replication (CSR), in which polymerases expressed in cells in emulsions undergo thermal cycling to amplify their own genes, to generate long read DNA polymerases that should prove capable of generating PCR amplicons > 100 kb in length, with few errors. To achieve this goal, we propose to develop a novel library construction method that most efficiently brings together sequence and structural domains from a variety of DNA polymerase variants to form diverse chimeras (Aim 1.1), and to sieve these libraries using improvements to CSR that will allow us to select for extreme processivity in yeast (Aim 1.2) and efficient error- correction (Aim 1.3). Using the methods in Aim 1.2, we can produce polymerase variants that should be able to directly participate in RT-qPCR without sample preparation, including from samples inactivated with denaturants. The variants that result will be characterized for their ability to synthesize long amplicons in vitro (Aim 2.1), for their fidelity (Aim 2.2), and for their detailed kinetic properties (Aim 2.3). Finally, to better ensure the processivity of the resultant polymerase chimeras, we will append either DNA-binding domains (Aim 3.1) or clamps (Aim 3.2) that should lead to much better ability to grip DNA. Using the methods described in Aim 3.1, we can generate thermostable reverse transcriptases that should prove useful for the development of isothermal amplification assays that can be used at point-of-care, or in resource-poor settings. In addition to accelerating the ongoing revolution in genome synthesis, such long-read polymerases should also pave the way to new sequencing technologies, including for single molecule sequencing and for single cell sequencing. In the current crisis, polymerase engineering for particular functions, directed towards needs that the community has and that need to be resolved for forward motion on testing, is a critical component of a national plan.", "keywords": [ "2019-nCoV", "Bacillus stearothermophilus", "Biological Assay", "Cells", "Chimera organism", "Chromosomes", "Closure by clamp", "Communities", "Country", "DNA", "DNA Binding Domain", "DNA Sequence", "DNA amplification", "DNA sequencing", "DNA-Directed DNA Polymerase", "Development", "Directed Molecular Evolution", "Emulsions", "Engineering", "Ensure", "Enzymes", "Genes", "Genome", "Goals", "High temperature of physical object", "In Vitro", "Industry", "Infrastructure", "International", "Introns", "Kinetics", "Lead", "Length", "Libraries", "Medicine", "Methods", "Motion", "Mutation", "Organism", "Patients", "Performance", "Polymerase", "Preparation", "Production", "Promega", "Property", "Protein Engineering", "RNA Splicing", "RNA-Directed DNA Polymerase", "Reagent", "Research", "Resources", "Reverse Transcription", "Saline", "Sampling", "Specificity", "Speed", "Stretching", "Structure", "System", "Technology", "Testing", "Variant", "Viral", "Virus", "Work", "Writing", "Yeasts", "commercialization", "grasp", "high throughput screening", "improved", "molecular diagnostics", "next generation", "novel", "novel sequencing technology", "pandemic disease", "point of care", "sample collection", "single cell sequencing", "single molecule", "synthetic biology", "thermostability", "tool", "trizol", "viral RNA", "whole genome" ], "approved": true } }, { "type": "Grant", "id": "9984", "attributes": { "award_id": "2149052", "title": "Doctoral Dissertation Research: Ontogenetic and environmental origins of pathogen disgust sensitivity", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "Cult Anthro DDRI" ], "program_reference_codes": [], "program_officials": [ { "id": 1931, "first_name": "Jeremy", "last_name": "Koster", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-05-01", "end_date": "2024-04-30", "award_amount": 25054, "principal_investigator": { "id": 25787, "first_name": "Carolyn", "last_name": "Hodges-Simeon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25786, "first_name": "Jessica K", "last_name": "Hlay", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 168, "ror": "", "name": "Trustees of Boston University", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "It has long been proposed that the emotion of disgust helps humans avoid illness. However, levels of disgust, also called disgust sensitivity, can vary greatly among different individuals, which has implications for their behavior. In particular, research suggests that people higher in disgust sensitivity are more motivated to avoid certain objects, situations, and people. This doctoral research project investigates the broad question: why do people vary in their disgust sensitivity? One framework suggests that differences in the childhood environment may lead to differences in adult disgust sensitivity. This project is among the first to measure disgust sensitivity across a wide range of childhood ages to understand how disgust changes throughout growth and development. The researchers also examine cultural, individual, and environmental variables that may explain differences between individuals in their disgust sensitivity. These findings may be useful to health and education initiatives that focus on reducing infection risk and mitigating the progression of pandemics. Such initiatives will be aided by understanding when, why, and how children are motivated to avoid infection, and how this may vary across individuals and groups.\n\nInfectious disease has been a longstanding feature of human societies. As a result, humans have seemingly developed cultural and biological strategies to avoid infectious exposure. Pathogen disgust sensitivity is proposed as one of the core motivational triggers to initiate avoidant behavior, yet little research has investigated how it develops during childhood or what explains variation among individuals. This project examines variables such as inflammation, energy budget, control over pathogen exposure, social learning, and gender, that may account for variation in pathogen disgust sensitivity across childhood. The researchers collect these variables using self-report and physiological measures among children 6 to 18 in two communities with distinctly different infection risk and access to resources. The empirical findings from this project will be integrated to build a biocultural understanding of individual and group variation in pathogen disgust sensitivity. Educational components of the project contribute to the goal of broadening participation in science.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 5, "pages": 1424, "count": 14236 } } }