Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=4&sort=program_reference_codes
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_reference_codes", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1397&sort=program_reference_codes", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=5&sort=program_reference_codes", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=program_reference_codes" }, "data": [ { "type": "Grant", "id": "4096", "attributes": { "award_id": "1607069", "title": "2016 Cellular & Molecular Fungal Biology GRC, Plymouth, New Hampshire, June 19-24, 2016", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [ { "id": 13758, "first_name": "Michael", "last_name": "Mishkind", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-07-01", "end_date": "2017-06-30", "award_amount": 15000, "principal_investigator": { "id": 13759, "first_name": "Amy", "last_name": "Gladfelter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will facilitate the attendance and participation of early career scientists in the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 19-24, 2016. The goal of the conference is to disseminate information about fungal biology among an interdisciplinary group of researchers, and to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are essential parts of the terrestrial nutrient cycle, play a central role in the development of biofuels, and produce many critically important chemicals. These diverse applications of fungi require the interdisciplinary acquisition and application of fundamental fungal biology. This project will support the convergence and exchange of new findings amongst an interdisciplinary group of scientists dedicated to the study of fungi. \n\nThe intellectual merit of the project is rooted in the meeting's highly interdisciplinary and interactive format. The meeting will feature topics that integrate multiple time and space scales for different questions in fungal biology to promote interactions amongst researchers with diverse perspectives within the community. There is a specific emphasis on integrating mathematical modeling and biophysics as a new addition to this meeting and an entire session is dedicated to the interface of fungal biology with the physical sciences. The meeting enables cross-fertilization of ideas, from cell biology to evolution, that occurs in and outside of the sessions and especially between junior and senior scientists. Young investigators emphasize from previous meetings how interactive the conference is and how responsive it is to the presentation of their work.\n\nThis conference has broad impacts on training and is dedicated to extending the research community by emphasizing women and members of underrepresented groups in inviting speakers. The current invited speakers are approximately 50% women, including several Latinas. The small size of the meeting and the emphasis on discussion (40% of meeting time is dedicated to discussions) encourages active participation. Poster sessions are featured without competing events to focus attention on the most junior scientists, who often have the newest data. The GRC on Cell and Molecular Fungal Biology also is dedicated to research that applies basic knowledge to socially important questions involving filamentous fungi, particularly mutualisms with plants (mycorrhizae), parasitism with plants (plant pathology) and animals (animal pathology), and industrial mycology (enzyme production). The interactions among researchers focused on both basic and socially important research speeds research aimed at solving societal problems caused by or that can be improved by fungi.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "768", "attributes": { "award_id": "2050640", "title": "Planning Virtual Strategies to Prepare Science and Mathematics Teachers in Mississippi", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)" ], "program_reference_codes": [], "program_officials": [ { "id": 1805, "first_name": "Susan", "last_name": "Carson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-03-01", "end_date": "2023-02-28", "award_amount": 124992, "principal_investigator": { "id": 1809, "first_name": "Mitchell M", "last_name": "Shears", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 396, "ror": "https://ror.org/01ecnnp60", "name": "Jackson State University", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 1806, "first_name": "Abu O", "last_name": "Khan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 1807, "first_name": "Alicia K", "last_name": "Jefferson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 1808, "first_name": "Nadine", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 396, "ror": "https://ror.org/01ecnnp60", "name": "Jackson State University", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true }, "abstract": "This project aims to serve the national need for skilled secondary science and mathematics teachers in high-need school districts. To do so, the project seeks to lay the foundation for secondary-education certification programs adapted to the novel demands of pre- and post-COVID teaching/learning environments. Conceived initially as a response to the COVID-19 pandemic, the project aims to use technology and virtual approaches to deliver remote learning opportunities for future teachers. As such, the project will enable Jackson State University to explore the feasibility of a large-scale effort to increase use of evidence-based, distance-learning strategies in teacher education. Examples of strategies include virtual simulations, digital credentialing, and online social and emotional learning. The work will be situated in the urban setting of the Mississippi State capital. This project at Jackson State University includes partnerships with Hinds Community College and Jackson Public Schools, a high-need school district. The long-term goal of this collaborative effort is plan how to recruit, support, and graduate teachers who will help meet the shortage of science and mathematics teachers at high-need schools often staffed by rotating long- and short-term substitute teachers. The project builds on the conceptual framework of Jackson State’s College of Education and Human Development vision of the “responsive educator” who provides and embodies: 1) a Committed Response; 2) a Knowledgeable Response; 3) a Skillful Response; and 4) a Professional Response. Additionally, the project builds on the current infrastructure of the University’s Physics and Mathematics Education curriculum. The goals of this Capacity Building project are to: 1) develop evidence-based innovative models and strategies for recruiting, preparing, and supporting teachers; 2) create plans for collecting data to determine need, interest, and capacity for increasing STEM teacher development; and 3) establish the infrastructure for preparing a Track 1: Scholarship & Stipend proposal in the future. This Capacity Building project is supported through the Robert Noyce Teacher Scholarship Program (Noyce). The Noyce program supports talented STEM undergraduate majors and professionals to become effective K-12 STEM teachers and experienced, exemplary K-12 teachers to become STEM master teachers in high-need school districts. It also supports research on the persistence, retention, and effectiveness of K-12 STEM teachers in high-need school districts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "9728", "attributes": { "award_id": "1R01HD107753-01", "title": "Maternal COVID-19 Vaccination and Lactation Outcomes", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8894, "first_name": "Zhaoxia", "last_name": "Ren", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2025-04-30", "award_amount": 618968, "principal_investigator": { "id": 25567, "first_name": "Kristin", "last_name": "Palmsten", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1861, "ror": "", "name": "HEALTHPARTNERS INSTITUTE", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "The efficacy of coronavirus disease (COVID-19) vaccines available in the US is up to 95% against symptomatic COVID-19. However, pregnant and lactating individuals were excluded from initial clinical trials. COVID-19 vaccine trials are now underway in pregnant women in their second or third trimester but are not expected to conclude until 2022 or 2023, and evaluation of lactation outcomes is not planned. COVID-19 vaccines are highly effective, and mounting evidence suggests immunogenic protection for breastfed infants of mothers receiving COVID-19 vaccines. To date, there are no published studies on COVID-19 vaccine safety during pregnancy or lactation for breastfed infants, milk production and excretion, or other lactation-related outcomes. This lack of safety data threatens to undermine vaccination efforts in pregnant and lactating women. Traditional data sources used for post-licensure surveillance have limited relevance for lactation outcomes . Spontaneous reporting systems suffer from reporting bias due to their voluntary nature; their lack of a denominator of vaccinated lactating women precludes risk estimates. The CDC's V-Safe program, smart phone-based monitoring for vaccine side effects, does not capture lactation status. Ongoing health care claims-based surveillance studies also do not routinely capture lactation. Observational studies enrolling COVID-vaccinated lactating women rely primarily on self-reported outcomes and have limited generalizability. To address the need for comprehensive safety data, we propose a novel study of antenatal and postpartum COVID-19 vaccination and lactation-related outcomes in mother-infant pairs, including more than 11,000 breastfeeding dyads. We will use electronic health record data linked with state immunization data across four large health systems to study infant growth, infant heath care utilization, maternal mastitis, and breastfeeding status up to 7 months after delivery following maternal COVID-19 vaccination. Also, we will explore acute infant outcomes and abnormal infant developmental screens following maternal COVID-19 vaccination. We are uniquely positioned to overcome lack of information on lactation status and reporting and volunteer bias using routinely collected information on breastfeeding at well-child visits for a defined population. We will apply rigorous epidemiologic methods, including propensity score adjustment, to address confounding. With a focus on lactation, our study will complement other studies of COVID-19 vaccination in pregnancy and studies collecting milk samples from COVID-19-vaccinated volunteers. It will provide essential and currently unavailable evidence regarding lactation-related outcomes following perinatal COVID-19 vaccination. Findings supporting safety can reduce vaccine hesitancy, whereas results identifying a potential harm will be important for informing patient decision making. Furthermore, the novel approach and methods for studying lactation related outcomes developed through the proposed study can be adapted to efficiently evaluate the safety of drugs and vaccines currently recommended or being investigated for use in pregnant or postpartum women.", "keywords": [ "Acute", "Address", "Age-Months", "Biological", "Body Composition", "Breast Feeding", "Breastfed infant", "COVID-19", "COVID-19 impact", "COVID-19 vaccination", "COVID-19 vaccine", "Caring", "Cellular Phone", "Centers for Disease Control and Prevention (U.S.)", "Clinical", "Clinical Trials", "Complement", "Cytomegalovirus", "Data", "Data Sources", "Decision Making", "Dehydration", "Development", "Discipline of obstetrics", "Dose", "Electronic Health Record", "Enrollment", "Epidemiologic Methods", "Evaluation", "Excretory function", "Fatigue", "Fever", "Frequencies", "Growth", "Guidelines", "Health system", "Healthcare", "Human", "Human Milk", "Icterus", "Immunization", "Individual", "Infant", "Inflammatory Response", "Influenza", "Lactation", "Licensure", "Link", "Malaise", "Methods", "Milk", "Monitor", "Mothers", "Nature", "Observational Study", "Outcome", "Patient Self-Report", "Patients", "Perinatal", "Population", "Positioning Attribute", "Postpartum Period", "Postpartum Women", "Pregnancy", "Pregnant Women", "Professional Organizations", "Publishing", "RNA vaccine", "Reporting", "Respiratory syncytial virus", "Risk", "Risk Estimate", "Safety", "Sampling", "Screening Result", "Second Pregnancy Trimester", "Surveys", "System", "Third Pregnancy Trimester", "Vaccinated", "Vaccination", "Vaccines", "Viral Proteins", "Viral Vector", "Well Child Visits", "Woman", "antenatal", "base", "coronavirus disease", "cytokine", "health care delivery", "health care service utilization", "immunogenic", "infant outcome", "mastitis", "medication safety", "milk production", "novel", "novel strategies", "perinatal period", "pregnant", "programs", "side effect", "surveillance study", "symptomatic COVID-19", "vaccine access", "vaccine hesitancy", "vaccine safety", "vaccine trial", "volunteer" ], "approved": true } }, { "type": "Grant", "id": "10752", "attributes": { "award_id": "2235455", "title": "DREAM Sentinels: Selection of aptamers that target viral variants with high specificity", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Engineering (ENG)", "BIOSENS-Biosensing" ], "program_reference_codes": [], "program_officials": [ { "id": 961, "first_name": "Aleksandr", "last_name": "Simonian", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-01-01", "end_date": "2025-12-31", "award_amount": 640000, "principal_investigator": { "id": 1593, "first_name": "Hsin-Chih", "last_name": "Yeh", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 156, "ror": "", "name": "University of Texas at Austin", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 26813, "first_name": "Yi", "last_name": "Lu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 156, "ror": "", "name": "University of Texas at Austin", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "To combat infectious diseases, this project will develop a versatile platform that has a much shorter turn-around time in generating a new capture molecule that specifically binds a new viral variant with high affinity. The investigators will further convert the captured molecule into a sensor for virus detection, and also turn it into a blocking molecule to neutralize the virus. The current selection process is time-consuming and labor intensive. The goal of this project is to develop a streamlined process that can rapidly target emerging viral variants with high affinity and specificity. The proposed work will advance our knowledge in virus sensing and therapeutics, establishing a quick-responsive biosensing/actuating All-In-One platform that can be easily adapted to address future infectious diseases. To increase impact, the investigators will work with local K-12 students in several outreach programs, with the goal of training the students to develop novel tools and encouraging them into a career path in science, technology, engineering and mathematics.\n\nDevelopment of aptamer sensors and therapeutics is hampered by the bottleneck in the workflow of current gold standard SELEX (systematic evolution of ligands by exponential enrichment), especially the counterselection process, which aims to eliminate the candidates that bind structurally similar relatives of the target. While the counterselection is key to selecting highly specific aptamers against a specific target, it is a time-consuming, labor-intensive process that often fails. To address this issue, this project will combine SELEX workflow with a complementary high-throughput chip selection approach that can fully characterize the binding affinity, kinetics and specificity of each aptamer variant in the library against a number of structurally similar viral targets. This total-analysis approach not only bypasses the need to perform counterselections but also allows selection of aptamers that can differentiate structurally similar viral targets. The virus-binding aptamers will then be integrated with novel fluorogenic aptamer design to create new sensors that light up upon binding the target viruses and can be turned into virus inhibitors that bind and block the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein from interacting with the angiotensin-converting enzyme 2 (ACE2) receptors on human host cells. The proposed research thus has both biosensing and bioactuation components that address new biological threats.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8448", "attributes": { "award_id": "1U01DD001293-01", "title": "Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-07-01", "end_date": "2026-06-30", "award_amount": 581307, "principal_investigator": { "id": 24212, "first_name": "Julie L", "last_name": "Daniels", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "- SEED Follow-up Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The NC SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in North Carolina and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "9216", "attributes": { "award_id": "3R01EB027202-01A1S1", "title": "Directed evolution of polymerases that can read and write extremely long sequences", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 24310, "first_name": "David", "last_name": "Rampulla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-01", "end_date": "2022-08-31", "award_amount": 182969, "principal_investigator": { "id": 4640, "first_name": "Andrew D", "last_name": "Ellington", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 156, "ror": "", "name": "University of Texas at Austin", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 972, "ror": "", "name": "UNIVERSITY OF TEXAS AT AUSTIN", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Supplemental Project Summary (derived from the original, changes underlined) Advances in synthetic biology have accelerated to the point where the synthesis of entire genomes is now possible. However, the technologies for these feats are painstaking, and the production of a new chromosome or genome requires multiple years of effort, working from small fragments to ever larger assemblies. The speed (and ultimately scale) of large fragment assembly would be greatly improved if it were possible to routinely amplify very long stretches of DNA (> 100 kb) in vitro. The methods developed in the execution of this proposal should also prove extremely useful for greatly improved reagents for molecular diagnostics for SARS-CoV-2. To that end, this proposal is focused on the further development of a novel directed evolution method known as Compartmentalized Self-Replication (CSR), in which polymerases expressed in cells in emulsions undergo thermal cycling to amplify their own genes, to generate long read DNA polymerases that should prove capable of generating PCR amplicons > 100 kb in length, with few errors. To achieve this goal, we propose to develop a novel library construction method that most efficiently brings together sequence and structural domains from a variety of DNA polymerase variants to form diverse chimeras (Aim 1.1), and to sieve these libraries using improvements to CSR that will allow us to select for extreme processivity in yeast (Aim 1.2) and efficient error- correction (Aim 1.3). Using the methods in Aim 1.2, we can produce polymerase variants that should be able to directly participate in RT-qPCR without sample preparation, including from samples inactivated with denaturants. The variants that result will be characterized for their ability to synthesize long amplicons in vitro (Aim 2.1), for their fidelity (Aim 2.2), and for their detailed kinetic properties (Aim 2.3). Finally, to better ensure the processivity of the resultant polymerase chimeras, we will append either DNA-binding domains (Aim 3.1) or clamps (Aim 3.2) that should lead to much better ability to grip DNA. Using the methods described in Aim 3.1, we can generate thermostable reverse transcriptases that should prove useful for the development of isothermal amplification assays that can be used at point-of-care, or in resource-poor settings. In addition to accelerating the ongoing revolution in genome synthesis, such long-read polymerases should also pave the way to new sequencing technologies, including for single molecule sequencing and for single cell sequencing. In the current crisis, polymerase engineering for particular functions, directed towards needs that the community has and that need to be resolved for forward motion on testing, is a critical component of a national plan.", "keywords": [ "2019-nCoV", "Bacillus stearothermophilus", "Biological Assay", "Cells", "Chimera organism", "Chromosomes", "Closure by clamp", "Communities", "Country", "DNA", "DNA Binding Domain", "DNA Sequence", "DNA amplification", "DNA sequencing", "DNA-Directed DNA Polymerase", "Development", "Directed Molecular Evolution", "Emulsions", "Engineering", "Ensure", "Enzymes", "Genes", "Genome", "Goals", "High temperature of physical object", "In Vitro", "Industry", "Infrastructure", "International", "Introns", "Kinetics", "Lead", "Length", "Libraries", "Medicine", "Methods", "Motion", "Mutation", "Organism", "Patients", "Performance", "Polymerase", "Preparation", "Production", "Promega", "Property", "Protein Engineering", "RNA Splicing", "RNA-Directed DNA Polymerase", "Reagent", "Research", "Resources", "Reverse Transcription", "Saline", "Sampling", "Specificity", "Speed", "Stretching", "Structure", "System", "Technology", "Testing", "Variant", "Viral", "Virus", "Work", "Writing", "Yeasts", "commercialization", "grasp", "high throughput screening", "improved", "molecular diagnostics", "next generation", "novel", "novel sequencing technology", "pandemic disease", "point of care", "sample collection", "single cell sequencing", "single molecule", "synthetic biology", "thermostability", "tool", "trizol", "viral RNA", "whole genome" ], "approved": true } }, { "type": "Grant", "id": "6656", "attributes": { "award_id": "3R41CA254557-01A1S2", "title": "PRANAYAMA BASED MOBILE APP FOR BREAST CANCER SURVIVORSHIP: I-CORPS SUPPLEMENT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22312, "first_name": "Patricia A", "last_name": "Weber", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-06-01", "end_date": "2023-05-31", "award_amount": 55000, "principal_investigator": { "id": 22313, "first_name": "SUNDARAVADIVEL", "last_name": "BALASUBRAMANIAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1484, "ror": "", "name": "PRANASCIENCE INSTITUTE LLC", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1484, "ror": "", "name": "PRANASCIENCE INSTITUTE LLC", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Cancer remains the second leading cause of deaths in the U.S. Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases in the survival rate of cancer patients. As cancer becomes a chronic but manageable disease for thousands of survivors, the long-term physical and psychological side effects of treatment protocols is becoming more apparent, as is the impact of these issues on disease-free or overall survival. As a result of this changing landscape, survivorship care programs and approaches that incorporate non-pharmacological lifestyle and mind-body interventions are becoming increasingly critical components of the patient treatment pathway. In this regard, integrative approaches such as yogic breathing (YB), a collection of techniques to voluntarily regulate breathing, have emerged as an effective complementary therapy for cancer patients. YB is well-established to induce strong relaxation responses via vagal and parasympathetic stimulation. YB is easy to practice using virtual tools such as mobile apps especially during the current scenario of COVID-19 pandemic and social distancing. In this application, PranaScience seeks to develop a novel group video app for YB that is optimized for home-based delivery of a proscribed YB program that is maximally effective in promoting peer support, and relieving symptomatic conditions associated with cancer treatment and survivorship. This intervention is based on compelling preliminary data generated by the PI of this proposal demonstrating that specific YB exercises induce alterations in the levels of proteins associated with tumor suppression, immune regulation, neuromodulation, and stress response/ inflammation, as well as pilot studies performed in cancer survivors and other patient/general populations indicating that participants are interested in a YB intervention and perceive improvements in well-being after YB sessions. In this Phase I STTR, PranaScience (1) has built a first production version of a culturally neutral group video YB app and (2) partners with the Medical University of South Carolina (MUSC) to pilot test the YB app in breast cancer survivors to evaluate adherence, feasibility, and acceptability of the app to support symptom management. App usage data is collected and used to evaluate adherence to the program, and acceptability for symptom management will be evaluated using a series of defined biobehavioral measures at baseline and following a 12-week implementation period. Exploratory salivary and fingernail biomarker analysis focused on tumor suppressors, inflammatory cytokines, proteome level alterations, and stress hormones will be performed at baseline and at week 12. Structured, focus group interviews of study participants will be used to assess technology perception/ program feasibility and will inform future design optimizations. Information from the I-Corps supplemental work will be used to refine app in preparation for large-scale evaluation in Phase II, and for commercialization purposes through customer discovery interviews.", "keywords": [ "Adherence", "American Cancer Society", "Antineoplastic Protocols", "Behavioral", "Biological Markers", "Breast Cancer survivor", "Breast Cancer survivorship", "Breathing", "Breathing Exercises", "COVID-19 pandemic", "Cancer Etiology", "Cancer Patient", "Cancer Survivor", "Cancer Survivorship", "Caregivers", "Caring", "Cause of Death", "Cessation of life", "Chronic", "Collection", "Communities", "Complementary therapies", "Computer software", "Control Groups", "Custom", "Data", "Development", "Disease", "Disease Management", "Early Diagnosis", "Early treatment", "Equipment and supply inventories", "Evaluation", "Evidence based intervention", "Exertion", "Fibrinogen", "Focus Groups", "Frequencies", "Funding", "Future", "Gene Expression", "General Population", "Goals", "Group Interviews", "Health", "Home", "Hormones", "Individual", "Inflammation", "Inflammatory", "Innovation Corps", "Institutes", "Integrative Medicine", "Intervention", "Interview", "Length", "Life", "Life Style", "Link", "Lung", "Malignant Neoplasms", "Measures", "Medical", "Meditation", "Mental Depression", "Metabolism", "Methods", "Mind-Body Intervention", "Modality", "Online Systems", "Outcome", "Participant", "Pathway interactions", "Patient Self-Report", "Patients", "Perception", "Personal Satisfaction", "Phase", "Pilot Projects", "Preparation", "Production", "Program Acceptability", "Proteins", "Proteome", "Psychological Side Effects", "Quality of life", "Radiation therapy", "Randomized", "Rehabilitation therapy", "Relaxation", "Resources", "Risk", "Salivary", "Secondary to", "Series", "Small Business Technology Transfer Research", "Social Distance", "South Carolina", "Stress", "Structure", "Structure of nail of finger", "Supportive care", "Surveys", "Survival Rate", "Survivors", "Symptoms", "System", "Techniques", "Technology", "Testing", "Time", "Treatment Protocols", "Treatment Side Effects", "Tumor Suppression", "Tumor Suppressor Proteins", "Universities", "Virtual Tool", "Visual", "Visual Aid", "Woman", "Work", "Yoga", "attentional control", "base", "biobehavior", "biological adaptation to stress", "cancer site", "cancer therapy", "cognitive process", "cohort", "commercialization", "cytokine", "design", "ethnic minority population", "evidence base", "healthy lifestyle", "healthy volunteer", "immunoregulation", "improved", "interest", "intervention delivery", "malignant breast neoplasm", "mobile application", "n" ], "approved": true } }, { "type": "Grant", "id": "6400", "attributes": { "award_id": "3U24AA022002-08S1", "title": "Southern HIV and Alcohol Research Consortium Administrative and Research Support Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21528, "first_name": "Deidra", "last_name": "Roach", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2012-09-25", "end_date": "2023-03-31", "award_amount": 152332, "principal_investigator": { "id": 21529, "first_name": "Robert L", "last_name": "Cook", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "It is not clear whether the coronavirus (COVID-19) pandemic has differentially affected HIV outcomes or drinking behavior among rural or ethnic minority populations. Understanding how COVID-19 changes HIV care and alcohol use could strengthen future HIV and alcohol care delivery to increase the resilience of these programs. Access to health research is also adversely affected by COVID-19. This shift to telehealth has potential to help clinicians and researchers connect with hard-to-reach populations. However, we need to understand feasibility and acceptability of telehealth by persons living with HIV (PLWH) if we are to extend research and improve delivery of alcohol interventions and HIV care in the future. This request is supplementary to U24AA022002, providing supportive infrastructure to the Southern HIV Alcohol Research Consortium (SHARC), including the FL Cohort. The objective of the FL Cohort is to better understand barriers and facilitators to viral suppression, focusing on alcohol use. However, the planned FL Cohort will not be able to distinguish if changes in alcohol use or HIV care are due to COVID-19, and will not have sufficient persons from rural or Haitian communities to assess differential effects in these underserved populations. This supplement will help determine how COVID-related social isolation and COVID disease have influenced the HIV care continuum, alcohol use and treatment, and acceptance of telehealth, stated interests in NOT-AA-20- 011 and high priority HIV research areas. The aims of this supplement are to: 1) Determine the impacts of COVID disease and related changes in psychosocial factors (e.g., loneliness, social support, economic insecurity, domestic violence) on alcohol use and HIV-related care and health outcomes (ART adherence, care engagement, and viral suppression) as assessed before and during social distancing measures; 2) Extend FL Cohort recruitment into rural areas and the Haitian community, and compare the psychosocial effects, changes in drinking, and HIV-related outcomes in rural vs. urban settings and within the Haitian community. 3) Assess the feasibility, acceptability, and interest in remote enrollment and data collection for research, and delivery of alcohol interventions and HIV clinical care among patients and providers, and compare optimal strategies across socio-demographic groups (e.g., age cohort, rural vs. urban, ethnic groups). We will accomplish these aims by adding an additional COVID-related questionnaire to the existing measures in the parent FL Cohort study, recruiting and additional 150 persons from rural areas and the Haitian community who will complete a single, “light” version of the study, and conducting qualitative interviews from PLWH and healthcare personnel to better understand how we can learn from the crisis to adapt new interventions. The study will have impact by directly informing strategies related to implementation of alcohol and HIV interventions, by expanding our knowledge related to the impact of a new infectious disease pandemic on drinking and HIV outcomes, and by enhancing the overall representativeness of our cohort sample.", "keywords": [ "AIDS/HIV problem", "Adherence", "Affect", "Age", "Alcohol consumption", "Alcohols", "Americas", "Area", "COVID-19", "COVID-19 pandemic", "Caring", "Clinical", "Cohort Studies", "Communicable Diseases", "Communities", "Continuity of Patient Care", "Coronavirus", "County", "Data", "Data Collection", "Data Reporting", "Disease", "Domestic Violence", "Economics", "Elderly", "Enrollment", "Epidemic", "Ethnic group", "Event", "Florida", "Funding", "Future", "HIV", "Haitian", "Health", "Health Personnel", "Healthcare", "Incidence", "Infrastructure", "Intervention", "Interview", "Knowledge", "Learning", "Left", "Light", "Loneliness", "Measures", "Medical", "Outcome", "Parents", "Participant", "Patient Self-Report", "Patients", "Persons", "Population", "Populations at Risk", "Positioning Attribute", "Prevalence", "Provider", "Psychosocial Factor", "Questionnaires", "Reporting", "Research", "Research Activity", "Research Personnel", "Research Support", "Resources", "Rural", "Rural Minority", "Sampling", "Shock", "Social Distance", "Social isolation", "Social support", "State Interests", "System", "Telemedicine", "Treatment/Psychosocial Effects", "Underserved Population", "Viral", "Visit", "Vulnerable Populations", "Work", "alcohol abuse therapy", "alcohol intervention", "alcohol misuse", "alcohol research", "care delivery", "care outcomes", "clinical care", "cohort", "comorbidity", "coronavirus disease", "drinking", "drinking behavior", "ethnic minority population", "experience", "improved", "interest", "member", "novel coronavirus", "pandemic disease", "programs", "recruit", "resilience", "rural area", "rural setting", "rural underserved", "sociodemographic group", "surveillance data", "telehealth", "treatment program", "urban setting" ], "approved": true } }, { "type": "Grant", "id": "8704", "attributes": { "award_id": "1U01HL158759-01", "title": "The effect of SARS-CoV-2 on the susceptibility of respiratory outcomes in a Puerto Rican Birth Cohort", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22703, "first_name": "Michelle M", "last_name": "Freemer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-20", "end_date": "2022-07-31", "award_amount": 646280, "principal_investigator": { "id": 24488, "first_name": "LUISA N", "last_name": "BORRELL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24489, "first_name": "Esteban Gonzalez", "last_name": "Burchard", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 24490, "first_name": "JOSE", "last_name": "RODRIGUEZ-SANTANA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. The lack of diagnostic tests and current public health policies limit our knowledge of the true prevalence of SARS- CoV-2. Infection with SARS-CoV-2 results in production of anti-viral antibodies in infected hosts, yet it is currently unknown whether these antibody responses are protective against subsequent infection. Survivors of the 2003 SARS coronavirus outbreak had reduced lung function and quality of life, and more frequent viral respiratory illnesses. The latter are associated with increased risk for childhood wheeze and asthma, the most common chronic and disparate disease among children. Data also indicate that there are significant racial/ethnic disparities in COVID-19 outcomes. Disparities in risk of viral exposure, susceptibility to severe disease, and access to health care may interact to exacerbate existing health inequalities. Pregnancy provides a natural mechanism by which to examine the protective potential of passive immunity. Maternal IgG is actively transported across the placenta and in the absence of postnatal exposure wane to undetectable levels in the neonate over the first year of life. Furthermore, IgA is passed from mother to child through breastmilk. Our multidisciplinary team will study a unique cohort of Puerto Rican mothers and their infants prospectively following the infants through their first five years of life collecting maternal breastmilk, maternal and neonatal cord blood, and neonatal/infant nasal epithelium swabs at birth, during respiratory illness, and at yearly clinical evaluations. We will determine prenatal exposure to SARS-CoV-2 as measured from maternal and infant cord blood at time of birth and investigate the effect this virus has on the susceptibility of respiratory disease in children. We will screen all pre/postpartum mothers with a PCR assay and qualitative immunoassay to detect SARS-CoV-2 infection. Among all seropositive mothers, we will collect repeated breast milk samples at 5 and 14 days and serial newborn blood spot samples at birth, 1, 3, 6 months, and yearly for 5 years. We will measure IgA, IgG, and IgM in maternal breastmilk and blood samples, and IgG in infant serum. We will examine (Aim 1) the passive transfer of SARS-CoV-2 immunity from seropositive mothers to their neonates, (Aim 2) whether early life SARS- CoV-2 infection severity and other clinical sequelae is modified by altered childhood immunophenotypes and host genetics, and (Aim 3) how socio-environmental factors affect maternal and infant exposure to COVID-19 and further affect the development of childhood asthma. We hypothesize that pregnant women infected with SARS-CoV-2 produce neutralizing antibodies, which protect their newborns from COVID-19 disease. In contrast, infants who contract SARS-CoV-2 after birth are at increased risk for later respiratory disease including asthma and other clinical sequelae. We further postulate that these associations are modified by host genetic and socio- environmental factors. To our knowledge, there are no other groups within or outside the U.S. with the population needed and track record to perform these analyses.", "keywords": [ "2019-nCoV", "21 year old", "5 year old", "Active Biological Transport", "Address", "Admixture", "Adult Respiratory Distress Syndrome", "Affect", "Antibody Response", "Asthma", "Biological", "Biological Assay", "Birth", "Blood", "Blood specimen", "Businesses", "COVID-19", "COVID-19 detection", "COVID-19 morbidity", "COVID-19 mortality", "COVID-19 pandemic", "COVID-19 severity", "Cessation of life", "Child", "Childhood", "Childhood Asthma", "Chronic", "Chronic Disease", "Clinic Visits", "Clinical", "Cohort Studies", "Contracts", "Data", "Development", "Diagnostic tests", "Disease", "Disease Outbreaks", "Ethnic Origin", "Exposure to", "Future", "Genetic", "Genetic Variation", "Health Policy", "Health Services Accessibility", "Human Milk", "Immune", "Immunity", "Immunoassay", "Immunoglobulin A", "Immunoglobulin G", "Immunoglobulin M", "Immunologics", "Immunophenotyping", "Individual", "Infant", "Infection", "Knowledge", "Latino", "Life", "Link", "Lung diseases", "Maternal Exposure", "Measures", "Metagenomics", "Minority", "Mothers", "Multisystem Inflammatory Syndrome in Children", "Nasal Epithelium", "Neonatal", "New York City", "Newborn Infant", "Outcome", "Participant", "Passive Immunity", "Peripheral Blood Mononuclear Cell", "Placenta", "Play", "Population", "Positioning Attribute", "Postpartum Period", "Predisposition", "Pregnancy", "Pregnant Women", "Prevalence", "Production", "Public Health", "Puerto Rican", "Puerto Rico", "Quality of life", "Race", "Recruitment Activity", "Risk", "Role", "SARS coronavirus", "SARS-CoV-2 antibody", "SARS-CoV-2 exposure", "SARS-CoV-2 immunity", "SARS-CoV-2 infection", "SARS-CoV-2 positive", "Sampling", "Schools", "Seasonal Variations", "Serology", "Serum", "Severities", "Social Environment", "Socioeconomic Status", "Spottings", "Survivors", "Swab", "Testing", "Time", "Umbilical Cord Blood", "Viral", "Viral Antibodies", "Viral Respiratory Tract Infection", "Virus", "Wheezing", "Woman", "antibody transfer", "base", "clinical risk", "cohort", "design", "disease disparity", "epidemiology study", "family structure", "genome-wide", "health care availability", "health inequalities", "high risk", "infant infection", "minority children", "mortality", "multidisciplinary", "neonatal immunity", "neonate", "neutralizing antibody", "pandemic disease", "peripheral blood", "postnatal", "pregnant", "prenatal exposure", "prospective", "pulmonary function", "racial and ethnic" ], "approved": true } }, { "type": "Grant", "id": "5888", "attributes": { "award_id": "3R01GM124280-04S1", "title": "Modeling ongoing SARS-CoV2 vaccination strategies in light of emerging data on immunity and viral evolution", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 20149, "first_name": "Han", "last_name": "Nguyen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-06-01", "end_date": "2023-05-31", "award_amount": 173135, "principal_investigator": { "id": 20150, "first_name": "Benjamin A", "last_name": "Lopman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "While SARS-CoV-2, the pathogen causing COVID-19, continues to spread, the rapid development and deployment of effective vaccines provide a means by which we can reduce its future impact. Initial vaccines have shown to be highly effective, however, the current emergence of new SARS-CoV-2 variants, together with indications that of waning immunity, means that continued repeat vaccinations are likely to be required. Here, we will build upon resources we have already developed from our ongoing project aimed at modeling potential norovirus vaccines and our previous work aimed at modeling the impact of vaccination for SARS-CoV-2 Our team has made contributions and investigated the relative population impacts of SARS-CoV-2 vaccines with different mechanisms of action; characterized patterns of virus evolution that have the potential to impact vaccine efficacy and escape; and, examined initial strategies for vaccine deployment with the aim of relaxing social distancing guidelines. We will leverage these data and modeling tools and build on this work to assess more fully the patterns of immune waning and virus evolution. We will then use these data and results and combine them with our existing SARS-CoV-2 vaccine simulation model to inform the building and the calibration of an extended model. This extended model will account for waning immunity to SARS-CoV-2 and its viral evolution. Our model will inform rapidly emerging scientific questions around continued SARS-CoV-2 vaccination and re-vaccination strategies, including both boosting and vaccine reformulation.", "keywords": [ "2019-nCoV", "Antibodies", "COVID-19", "COVID-19 vaccination", "COVID-19 vaccine", "Calibration", "Collection", "Computer Simulation", "Data", "Development", "Evolution", "Future", "Guidelines", "Immune", "Immunity", "Incidence", "Infection", "Light", "Modeling", "Norovirus", "Pattern", "Population", "Public Health", "Publications", "Recommendation", "Resources", "Role", "SARS-CoV-2 immunity", "SARS-CoV-2 infection", "SARS-CoV-2 variant", "Serology", "Social Distance", "Statistical Models", "Vaccination", "Vaccines", "Viral", "Virus", "Work", "models and simulation", "pathogen", "tool", "vaccination strategy", "vaccine distribution", "vaccine efficacy", "vaccine-induced immunity" ], "approved": true } } ], "meta": { "pagination": { "page": 4, "pages": 1397, "count": 13961 } } }