Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=4&sort=funder_divisions
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=funder_divisions", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1397&sort=funder_divisions", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=5&sort=funder_divisions", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=funder_divisions" }, "data": [ { "type": "Grant", "id": "7944", "attributes": { "award_id": "1I01HX003364-01A1", "title": "Dissemination and Implementation of a Videoconference Antimicrobial Stewardship Team (VAST)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-05-01", "end_date": "2026-04-30", "award_amount": null, "principal_investigator": { "id": 23816, "first_name": "CHARLESNIKA T", "last_name": "EVANS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1483, "ror": "https://ror.org/01vrybr67", "name": "Louis Stokes Cleveland VA Medical Center", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23817, "first_name": "Robin", "last_name": "Jump", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1483, "ror": "https://ror.org/01vrybr67", "name": "Louis Stokes Cleveland VA Medical Center", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "Background: Antimicrobial stewardship guidelines call for a multidisciplinary team with an infectious disease (ID) physician and ID-trained clinical pharmacist as core members. Unfortunately, there are insufficient ID- trained specialists to staff on-site antimicrobial stewardship programs throughout VA. Significance: This proposal is highly significant for Veterans and the goals of VA. Veterans experience many of the risk factors associated with development of antimicrobial resistant and healthcare-associated infections. The unprecedented effects of the novel Coronavirus disease 2019 (COVID-19) on the health of our Veterans and on our entire healthcare system makes the demand for ID expertise even more apparent, especially in long-term care. Also, this study directly addresses the VA MISSION ACT to improve access to care, timeliness and quality of care, using telehealth services. Finally, this project is aligned with the priorities of our operation partners: VA Antimicrobial Stewardship Taskforce (ASTF), the VA National Infectious Disease Service (NIDS), VA Pharmacy Benefits Management (PBM) Services, and the Office of Rural Health. Innovation and Impact: The design is innovative because we will systematically test and assess implementation barriers to telehealth for antimicrobial stewardship, a novel approach that has not been implemented in VA facilities, other than in our previous pilot study. Further, the Antibiotic Use Reports (AURs) are an innovative adaptation of peer-comparison, an antibiotic stewardship strategy successful in outpatient settings. This project will provide findings for a scalable model that could be deployed nationally to all applicable VAMCs, continuing the role of VHA as a leader in implementing large-scale interventions focused on prevention and management of ID and stewardship. Specific Aims: Our goal is to implement a multidisciplinary videoconference antimicrobial stewardship team (VAST) in VAMCs using SCAN-ECHO. Our central hypothesis is that feedback reports that quantify facility- level antibiotic use will enhance the efficacy of VASTs to support antimicrobial stewardship. We propose a Type 2 hybrid effectiveness-implementation design, comparing clinical effectiveness in sites that implement the VAST alone (VAST-) to sites that implement the VAST augmented by facility-level Antibiotic Use Reports (VAST+). Aims are: 1) Identify and test effective strategies for implementing the VAST; 2) Determine the influence of the VAST overall and VAST+ on the care of Veterans with suspected infections; 3) Determine the influence of the VAST overall and VAST+ on antibiotic use at each VAMC. Methodology: We will randomize rural VAMCs that do not have ID-trained professionals on staff to implement the VAST alone (VAST-) versus VAST + antibiotic use feedback (VAST+). Aim 1: We will assess modification and adaptations at the intervention sites and by the infectious disease experts. Methods will include process maps and semi-structured interviews to gather qualitative data about what key VAST members perceive as facilitators, barriers and burden to VAST implementation. We will also evaluate costs of implementation. Aim 2: We will evaluate the Veteran population served, clinical activities, and user perceptions of the VAST. We will assess the concordance of clinical care with recommendations from evidence-based clinical practice guidelines. VAST members’ perceptions of the quality and timeliness of care will be evaluated. Aim 3: The primary outcome measure will be overall rates of antibiotic use. Secondary outcomes will be changes in the rates of broad-spectrum antibiotic use, antibiotic starts, and length of antibiotic therapy. Next steps/Implementation: Testing effective implementation of the VAST at additional VAMCs is an important step toward augmenting antimicrobial stewardship in both acute- and long-term care settings. In collaboration with VA clinical operation partners, outcomes from this trial will be used to roll-out an implementation playbook to be used by other VAMCs, as well as non-VA settings.", "keywords": [ "Acute", "Address", "Administrator", "Affect", "Antibiotic Therapy", "Antibiotics", "Antimicrobial Resistance", "Area", "COVID-19", "Caring", "Cellulitis", "Cessation of life", "Clinical", "Clinical Nurse Specialists", "Clinical Pharmacists", "Clinical Practice Guideline", "Clinical effectiveness", "Collaborations", "Communicable Diseases", "Community Healthcare", "Complex", "Consultations", "Data", "Development", "Dissemination and Implementation", "Effectiveness", "Evidence based intervention", "Feedback", "Goals", "Guidelines", "Health", "Health Services Accessibility", "Healthcare", "Healthcare Systems", "Improve Access", "Individual", "Infection", "Infection Control", "Intervention", "Interview", "Length", "Long-Term Care", "Maps", "Measures", "Medical center", "Mentors", "Methodology", "Methods", "Modeling", "Modification", "Outcome", "Outcome Measure", "Outpatients", "Participant", "Patient Care", "Perception", "Pharmacists", "Physicians", "Pilot Projects", "Pneumonia", "Policy Maker", "Prevention", "Process", "Provider", "Quality of Care", "Randomized", "Recommendation", "Reporting", "Resources", "Risk Factors", "Role", "Rural", "Rural Health", "Services", "Site", "Specialist", "Structure", "System", "Testing", "Time", "Training", "United States Department of Veterans Affairs", "Urinary tract infection", "Veterans", "Work", "antimicrobial", "base", "care outcomes", "care providers", "clinical care", "combat", "design", "effectiveness implementation design", "effectiveness implementation study", "evidence base", "evidence based guidelines", "experience", "feasibility testing", "geographically distant", "global health", "healthcare-associated infections", "implementation barriers", "implementation cost", "implementation evaluation", "improved", "innovation", "interest", "medical specialties", "member", "military veteran", "multidisciplinary", "novel coronavirus", "novel strategies", "operation", "pathogen", "patient safety", "patient subsets", "peer", "pharmacy benefit", "prevent", "primary outcome", "programs", "secondary outcome", "telehealth" ], "approved": true } }, { "type": "Grant", "id": "8960", "attributes": { "award_id": "1I01HX003269-01A2", "title": "Social and Behavioral Determinants of Health in High-Risk Veterans", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2025-09-30", "award_amount": null, "principal_investigator": { "id": 24796, "first_name": "MATTHEW L", "last_name": "MACIEJEWSKI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1497, "ror": "", "name": "VETERANS ADMIN PALO ALTO HEALTH CARE SYS", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24797, "first_name": "Donna Michelle", "last_name": "Zulman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1497, "ror": "", "name": "VETERANS ADMIN PALO ALTO HEALTH CARE SYS", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Background. Social factors exert a substantially more potent impact on health than does health care, especially among disadvantaged populations such as VA users. Adverse social determinants of health (SDH)—factors such as housing instability, food insecurity, social isolation, and transportation barriers—are linked to problems with access, poorer clinical outcomes, and increased health care costs. Despite the clinical and business case for integrating SDHs into health care, these factors are not systematically assessed or addressed in clinical settings. Significance/Impact. This study will leverage a previous survey of Veterans at high-risk for hospitalization, and a new survey to be fielded to a nationally-representative sample of Veterans, to determine how SDHs influence clinical, health care utilization, and experience outcomes. Review of findings by key stakeholders will generate recommended SDH measures for universal screening within VA. These steps, coupled with qualitative interviews about implementation challenges, will inform the future integration of high-value patient-reported SDH measures into VA’s health record. Innovation. The proposed work is innovative in its evaluation of a broad array of SDHs in high-need Veterans to identify candidate measures for electronic health record (EHR) integration. The study will leverage a theoretically-driven survey of SDH measures with a data-driven approach to identifying the associations between these SDHs and a range of health, utilization, and patient experience outcomes. Results from these analyses will inform a facilitated deliberative process to prioritize high-value, validated, and actionable measures that are predictive of outcomes that are important to Veterans and the VA. Specific Aims. In Aim 1, we will use data from an Office of Primary Care-funded survey of Veterans at high-risk for hospitalization to examine relationships between patient-reported SDH measures and utilization, cost, and days in the community outcomes. In Aim 2, we will field a survey to a nationally-representative sample of VA patients to determine the association between SDH measures and key outcomes, and to examine the prevalence of SDHs in subpopulations of Veterans who are disproportionately affected by disparities (e.g., women, racial/ethnic minorities, and rural Veterans). Aims 1 and 2 will inform partner and stakeholder discussions in Aim 3 to identify measures that are associated with key outcomes and that are perceived by operations partners as actionable (i.e., addressable through VA or community services) and thereby good candidates for EHR integration. Methodology. In Aim 1, we will leverage data from an operations-funded survey that our team administered in 2018. Using survey data for 4,685 Veterans at high-risk for hospitalization, we will examine the association between patient-reported SDHs and utilization (i.e., VA and Medicare emergency department visits and hospitalizations), VA and Medicare costs, and days in the community. In Aim 2, we will field a similar survey to a nationally-representative sample of Veterans, evaluate the association between SDHs, patient experiences (e.g., perceived access and coordination), and 12-month VA emergency department visits, hospitalizations, and costs, and describe the prevalence of SDHs in the general VA population and Veterans who are at risk for health disparities. In Aim 3, we will use a facilitated deliberative process with key stakeholders to prioritize actionable SDH measures for EHR integration, and then conduct qualitative interviews with health system leaders, clinicians, staff, and patients to examine implementation barriers and facilitators to assessing select SDH measures at point of care. Implementation/Next Steps. This study addresses health equity, particularly relevant in light of COVID-19, and will be conducted with partners from VA’s Offices of Primary Care, Health Equity, Rural Health, and Women’s Health. The study is especially timely with VA’s transition to the new Cerner EHR as the proposed aims will identify SDH measures for potential EHR integration that are concise, actionable, and predictive of important outcomes.", "keywords": [ "Academy", "Accident and Emergency department", "Address", "Affect", "Area", "Bed Occupancy", "Behavioral", "Businesses", "COVID-19", "COVID-19 pandemic", "Caregivers", "Caring", "Clinical", "Communities", "Community Services", "Coupled", "Data", "Disadvantaged", "Economics", "Electronic Health Record", "Emergency department visit", "Environmental Risk Factor", "Evaluation", "Financial Hardship", "Funding", "Future", "Goals", "Health", "Health Care Costs", "Health system", "Healthcare", "Hospital Costs", "Hospital Departments", "Hospitalization", "Hospitals", "Individual", "Integrated Health Care Systems", "Intervention", "Interview", "Lead", "Leadership", "Life", "Light", "Link", "Measurement", "Measures", "Medicare", "Medicine", "Methodology", "Minority", "Modeling", "Outcome", "Patients", "Population", "Positioning Attribute", "Predictive Value", "Prevalence", "Prevention", "Primary Health Care", "Procedures", "Process", "Recommendation", "Reporting", "Research", "Research Personnel", "Respondent", "Rest", "Risk", "Risk Adjustment", "Rural", "Rural Health", "Sampling", "Screening procedure", "Shapes", "Social isolation", "Surveys", "System", "Time", "Transportation", "Trust", "United States Department of Veterans Affairs", "Variant", "Veterans", "Veterans Health Administration", "Woman", "Women&apos", "s Health", "Work", "base", "clinical care", "cost", "disadvantaged population", "economic outcome", "ethnic minority population", "experience", "food insecurity", "health care service utilization", "health care settings", "health disparity", "health equity", "health record", "high risk", "housing instability", "implementation barriers", "implementation facilitators", "improved", "innovation", "interoperability", "operation", "outcome prediction", "patient population", "point of care", "racial and ethnic", "screening", "social", "social factors", "social health determinants", "social vulnerability" ], "approved": true } }, { "type": "Grant", "id": "7937", "attributes": { "award_id": "1IK6BX005962-01", "title": "BLR&D Research Career Scientist Application", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-04-01", "end_date": "2027-03-31", "award_amount": null, "principal_investigator": { "id": 23807, "first_name": "Todd A", "last_name": "Wyatt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1645, "ror": "", "name": "OMAHA VA MEDICAL CENTER", "address": "", "city": "", "state": "NE", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1645, "ror": "", "name": "OMAHA VA MEDICAL CENTER", "address": "", "city": "", "state": "NE", "zip": "", "country": "United States", "approved": true }, "abstract": "My primary research interests address chronic inflammatory lung disease, and the impact that behavioral and environmental exposures play in the compromise of lung innate defense against pathologic lung infections and injury. Utilizing pre-clinical mouse models and state-of-the-art molecular, biochemical, and cellular approaches, I collaborate closely with pulmonologists who practice at the VA to conduct relevant pre-clinical research that can be used to address current clinical concerns. I translate my findings to Veterans’ health using a well- characterized human lung cell and tissue biobank obtained from our lung transplant program. We have an existing cohort of Veterans with rural/agricultural occupational exposures to conduct relevant studies to our service region. There are 3 major research projects currently underway that impact veterans’ health: Malondialdehyde-acetaldehyde adducts and lung injury. Alcohol abuse causing increased susceptibility to pneumonia has been known for over 200 years. Because the majority (>90%) individuals misusing alcohol smoke cigarettes, we study the combination lung injury effects of both cigarettes and alcohol. We identified that the lungs represent a unique environment for the formation of stable malondialdehyde-acetaldehyde protein adducts (MAA adducts), but only under conditions of combined cigarette smoke and alcohol exposure. These MAA adducts cause airway epithelial cell cilia slowing and impair the innate pathogen clearance from the lung. Surfactant protein D (SPD) is a major lung protein that gets adducted when lung aldehyde concentrations are elevated during combined smoke and alcohol exposure and SPD-MAA adducts are detected in the lung only in drinkers who also smoke, leading to alterations in innate lung defense. (Funded by BX003635). Veterans- centric COVID-19 research. The pathogenesis of the SARS-CoV-2 virus and clinical outcomes from COVID 19 are far worse in individuals with certain pre-existing conditions and those of advanced age. It is essential to the health of Veterans to fully define which at-risk conditions particularly impact them and their unique needs to empower clinical preventive care during this and future viral pandemics. Old age and alcohol misuse are associated with cilia dysfunction. SPD has been documented to specifically bind to and neutralize the Spike protein of coronavirus. We hypothesize that altered innate lung defense at the level of mucociliary clearance, anti-microbial surfactants, and viral receptor function will negatively impact susceptibility and pathogenesis of SARS-CoV-2, placing Veterans particularly in harm’s way. We are currently identifying differences in SARS- CoV-2 infection responses between normal airway epithelium and lung macrophages and those cells collected from individuals with COPD, with alcohol use disorder, or of old age. Defining the modalities of risk will empower clinicians to make informed clinical preventive care decisions for Veterans (Funded by BX005413). Agricultural organic dust-mediated lung injury. VISN 23 encompasses a region responsible for the largest agricultural output in the nation. In collaboration with Omaha VA physician scientists, we have built a cohort of Veterans with agricultural exposures to explore the impact of organic dusts on chronic lung inflammatory injury. Using established mouse models, we have identified the therapeutic impact of IL-10 on lung repair from dust- mediated injury. We are currently defining the mechanisms of action through an active NIOSH R01 study and the Central States Center for Agricultural safety and Health (Funded by OH010162). With these innovative research programs, I have been able to provide training and mentoring to many undergraduates, graduate students, fellows, junior scientists and physicians at the Omaha VAMC and affiliated University of Nebraska Medical Center (UNMC). Our efforts to investigate the underlying mechanisms and identify targets for pulmonary disease have brought together physician scientists and basic scientists at the Omaha VA medical center and UNMC, which has led to the development of a VA-funded live-animal microCT Core facility, which I supervise and is the only such instrument in Omaha.", "keywords": [ "2019-nCoV", "Acetaldehyde", "Address", "Admission activity", "Age", "Agriculture", "Alcohol abuse", "Alcohol consumption", "Alcohols", "Aldehydes", "Animal Model", "Animals", "Area", "Award", "Bacterial Infections", "Behavioral", "Binding", "Biochemical", "Biological Markers", "COVID-19", "Caring", "Cells", "Chronic", "Chronic Obstructive Pulmonary Disease", "Chronic lung disease", "Cigarette", "Cilia", "Clinical", "Collaborations", "Core Facility", "Coronavirus spike protein", "Cyclic AMP-Dependent Protein Kinases", "Development", "Dust", "Elderly", "Environment", "Environmental Exposure", "Epithelial Cells", "Exposure to", "Extramural Activities", "Functional disorder", "Funding", "Future", "Grant", "Health", "Health Care Costs", "Healthcare", "Healthcare Systems", "Heavy Drinking", "Hospitals", "Human", "Impairment", "Individual", "Inflammation", "Inflammatory", "Injury", "Interleukin-10", "Laboratories", "Life", "Lung", "Lung Transplantation", "Lung diseases", "Lung infections", "Malondialdehyde", "Manuscripts", "Mediating", "Medical center", "Mentors", "Methodology", "Military Personnel", "Modality", "Molecular", "Morbidity - disease rate", "Mucociliary Clearance", "Natural Immunity", "Nebraska", "Occupational Exposure", "Outcome", "Output", "Pathogenesis", "Pathologic", "Peer Review", "Physicians", "Play", "Pneumonia", "Predisposition", "Preventive care", "Proteins", "Pulmonary Surfactant-Associated Protein D", "Recording of previous events", "Regulation", "Research", "Research Project Grants", "Respiratory Syncytial Virus Infections", "Risk", "Role", "Rural", "SARS-CoV-2 infection", "SARS-CoV-2 pathogenesis", "Safety", "Sampling", "Savings", "Science", "Scientist", "Seminal", "Services", "Smoke", "Smoker", "Smoking", "Source", "Substance abuse problem", "Supervision", "System", "TNF-alpha converting enzyme", "Therapeutic", "Time", "Tissues", "Training", "Translating", "Universities", "Veterans", "Viral", "Virus", "Virus Diseases", "Virus Receptors", "Work", "adduct", "agricultural center", "airway epithelium", "airway inflammation", "alcohol exposure", "alcohol misuse", "alcohol response", "alcohol use disorder", "antimicrobial", "biobank", "career", "cell motility", "chronic inflammatory lung disease", "cigarette smoke", "cohort", "cost", "desensitization", "digital", "disorder risk", "experience", "exposure to cigarette smoke", "former smoker", "graduate student", "human old age (65+)", "improved" ], "approved": true } }, { "type": "Grant", "id": "12035", "attributes": { "award_id": "5T42OH008673-18", "title": "North Carolina Occupational Safety and Health Education and Research Centers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-07-01", "end_date": "2027-06-30", "award_amount": 1386730, "principal_investigator": { "id": 26183, "first_name": "LEENA A", "last_name": "NYLANDER-FRENCH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "This is a competing renewal application for the North Carolina Occupational Safety and Health Education and Research Center (NC OSHERC). Our unique Center builds upon the strengths of the occupational health and safety (OHS) education and research programs at the University of North Carolina at Chapel Hill, Duke University, and North Carolina State University. Nearly 62% of US adults are employed, and work exerts an independent, powerful influence on their health and safety. As we conducted needs and strengths assessments in preparation for this Center proposal, we saw how the COVID- 19 pandemic created a massive re-shaping of work, work conditions, and worker health, particularly related to safety, mental health, and well-being among essential and underserved workers. This observation has strengthened our joint efforts with both our regional Education and Research Center colleagues and other OHS partners to serve the emerging needs of occupational health professionals and the diverse workforce. The guiding mission of the NC OSHERC is to provide high- quality education and research training in the OHS sciences for the protection and promotion of worker health and well- being and to prevent occupational illness and injury in North Carolina, the southeast region, and the nation. To fulfill this mission, our goals are to (1) train future leaders to meet the nation’s OHS research needs and NIOSH priority goals and (2) bridge the gap between the innovative research being conducted in OHS within the regional universities and the needs of the region’s workforce. We will accomplish these goals through interdisciplinary OHS training, research, and service. The proposed education and research program’s specific aims are to: 1. Train practitioners, educators, and researchers in the academic disciplines of occupational exposure science and industrial hygiene, occupational medicine, safety and ergonomics, occupational epidemiology, and Total Worker Healthâ, with a specific focus given to training diverse, underrepresented, and minority practitioners and researchers. 2. Provide interdisciplinary learning experiences through coursework, practice and field projects, research activities, and seminars. Academic training and targeted research training programs guide trainees to develop skills in scientific inquiry and research to practice (r2p) to mitigate and eliminate hazards and improve working conditions. 3. Provide outreach and continuing education training programs to meet the needs of practitioners and OHS stakeholders. 4. Fund pilot research projects to support the development of young investigators and advance OHS science. The NC OSHERC is uniquely positioned to increase capacity and address the future challenges of OHS training, research, and preparedness in the Southeast and the nation by training diverse OHS practitioners and professionals in the challenging interdisciplinary OHS field and by fostering greater collaboration between academic researchers, local, state, and federal occupational professionals, as well as business and industry sector stakeholders. The NC OSHERC’s overall program responds to mandates in the OSHA Act, section 2(b)(5) and addresses the National Occupational Research Agenda (NORA) 2019 – 2024 priorities and critically important OHS issues in the NORA sector and cross-sector areas.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8707", "attributes": { "award_id": "6R03OH012215-01M002", "title": "COVID-19 Exposure, Response, Physical and Mental Health Sequelae among Nurses in New York State", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 24486, "first_name": "Maria", "last_name": "Lioce", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-01", "end_date": "2023-08-30", "award_amount": 80724, "principal_investigator": { "id": 24491, "first_name": "Marlene", "last_name": "Camacho", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 815, "ror": "https://ror.org/0041qmd21", "name": "SUNY Downstate Medical Center", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 815, "ror": "https://ror.org/0041qmd21", "name": "SUNY Downstate Medical Center", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "9738", "attributes": { "award_id": "1R01HS028671-01A1", "title": "Impact of EMTALA on Access to and Quality of Emergency Care", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 24040, "first_name": "Fred", "last_name": "Hellinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2027-04-30", "award_amount": 400000, "principal_investigator": { "id": 25580, "first_name": "Seth", "last_name": "Seabury", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25581, "first_name": "Sophie", "last_name": "Terp", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Before the 1986 enactment of the Emergency Medical Treatment and Labor Act (EMTALA), emergency departments (EDs) could legally turn away patients with emergency conditions based upon condition or ability to pay. EMTALA imposed a duty to treat, requiring that all patients presenting to an ED receive a timely medical screening evaluation, stabilization, and transfer if specialized stabilizing services are needed, regardless of condition or ability to pay. Hospitals are required to accept transfer of patients from other EDs if the receiving facility has specialized services required to stabilize their condition. Compliance with EMTALA is a condition of Medicare participation, and failure to comply with EMTALA can result in termination of a hospital’s Medicare provider agreement, a serious consequence that can result in hospital closure. EMTALA is actively enforced with a quarter of U.S. hospitals cited for violating the law within the past decade. Faced with an EMTALA citation, hospitals have two principal options to improve EMTALA compliance. First, they could enhance policies, procedures and service availability - improving access to and quality of care. Alternatively, hospitals could eliminate service lines reducing both responsibilities under EMTALA as well as access to care for the population served by the hospital. Indirect evidence suggests that some hospitals have responded to EMTALA enforcement in ways that might paradoxically reduce access to or quality of emergency care, likely exacerbating disparities. However, no publications directly evaluate how EMTALA enforcement impacts access to or the quality of emergency care. Nor is it known how hospitals responded to EMTALA enforcement in the wake of the COVID- 19 pandemic. To address this knowledge gap, we propose to build on an existing dataset and create a file including all EMTALA citations from 2011-present and link with data from the Healthcare Cost and Utilization Project (HCUP) State Emergency Department Databases (SEDD), the State Inpatient Databases (SID), Hospital Compare data to complete a study with the following Aims: (1) To evaluate whether access to emergency care improves following EMTALA citation (2) To assess whether disparities in access to care change in response to EMTALA citation, (3) To determine if quality of emergency care changes in response to EMTALA citations, (4) To quantify whether these effects varied during the COVID-19 pandemic, and finally (5) To characterize corrective action plans proposed by hospitals in response to citation to determine which actions and operational changes are associated with change in access to or quality of care. Understanding whether EMTALA enforcement impacts access to and quality of emergency care, and which corrective action plans serve as likely mechanisms for observed changes will be imperative to informing future efforts to enhance or improve the statute to ensure access to quality emergency care for historically underserved populations, and in particular low-income and minority groups, all AHRQ priority populations.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11779", "attributes": { "award_id": "1I01BX006010-01A1", "title": "Vaccinating at Mucosal Surfaces with Nanoparticle-conjugated Antigen and Adjuvant", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-04-01", "end_date": "2027-03-31", "award_amount": null, "principal_investigator": { "id": 27656, "first_name": "SEBASTIAN", "last_name": "JOYCE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "The incidence of tuberculosis (TB) has increased among Veterans in recent years because global TB burden has escalated with the emergence of multidrug-resistant and extremely drug resistant Mycobacterium tuberculosis (Mtb) strains. Further, current vaccines do not elicit long-lasting protective immunity against TB, especially in adults. Hence, this application addresses a critical unmet need for an effective vaccine against TB and thereby, significantly improve the quality of life of our Veterans. Herein, we propose pre-clinical studies that will identify protective CD8+ T cell epitopes and develop intranasal vaccine delivery platforms for the design of next generation TB vaccines. The global burden of TB caused by Mycobacterium tuberculosis (Mtb) infection is enormous. A third of the world’s population is currently infected with Mtb, an airborne pathogen that causes ~1.5 million deaths annually. The escalating emergence of multidrug-resistant and extremely drug resistant Mtb strains for which treatment options are costly and limited, further exacerbates global burden. This problem persists because current vaccines do not elicit long-lasting protective immunity against TB, especially in adults. The challenge is multifaceted because Mtb enters the host through the respiratory tract and, therefore, optimal protection will require installation of lung-resident CD4+ and CD8+ memory T cells positioned at the frontline to respond immediately to an infection. Traditional vaccines and approved adjuvants typically elicit weak, short- lived T cell responses, and parenteral vaccination is ineffective at installing protective immunity within the mucosae. Moreover, most virus-vectored and subunit TB vaccines employ a small subset of Mtb antigens, resulting in insufficient epitope diversity for optimal protection, partly because the epitopes that are presented during Mtb infection and confer protective immunity are not fully defined. Hence, our overall objective is to discover immunogenic, protective Mtb epitopes and to incorporate them in an innovative nanoparticle (NP)- based intranasal vaccine designed to promote a balanced CD4+ and CD8+ T cell responses in the lungs that are protective against TB. As a means to accomplish this goal, we discovered >10,000 peptides that bind to HLA- A*02:01, B*07:02, B*35:01, & B*35:03 in a high-throughput binding assay using ultrahigh-density peptide arrays. Now the challenge is to identify epitopes recognised by Mtb-reactive CD8+ T cells that can protect against infection in a preclinical, humanised HLA-Itg mouse models. Moreover, using different infection models, we have developed multiple nanoparticle platforms for simultaneous delivery of antigens and adjuvants that efficiently generate protective, tissue resident CD8+ T cells (Trm). Guided by these exciting published and preliminary results, we will test this central hypothesis: Intranasal immunization with subunit vaccines consisting of novel Mtb antigens and adjuvant will generate CD8+ Trm responses in the lungs. Installation of Mtb-reactive CD8+ Trm at the port of pathogen entry will protect against a lethal, aerosol challenge of three novel humanised mouse models with [there] clinical isolate of virulent Mtb, [including] HN878. Our strategy to test this hypothesis is to, (a) define immunodominant CD8+ T cell epitopes presented by HLA-B*07:02 that protect B7.2tg mice from Mtb infections; and (b) define common immunodominant CD8+ T cell epitopes presented by multiple B*07:02-related alleles [called B7 supertype] that protect HLA-I transgenic mouse models from Mtb infections. Our multidisciplinary team —consisting of biochemists, immunologists, microbiologists, and bioengineer, is ideally situated to pursue the stated Specific Aims. We anticipate that successful completion of the proposed research will inform next generation vaccine design against Mtb infections and TB disease. Our innovative “discover and deliver” approach to vaccine design will impact clinical practice paradigms against TB and other pulmonary infectious diseases such as SARS-COVID19 and Flu. Thereby, vaccine paradigms emerging from our research bears with it the promise to significantly improve the quality of life of our Veterans.", "keywords": [ "Academic Medical Centers", "Address", "Adjuvant", "Adult", "Aerosols", "Alleles", "Antigen Presentation Pathway", "Antigens", "Bacteria", "Binding", "Biological Assay", "Biomedical Engineering", "CD8-Positive T-Lymphocytes", "CD8B1 gene", "COVID-19", "Cells", "Cellular biology", "Cessation of life", "Chronic", "Clinical", "Common Epitope", "Communicable Diseases", "Disease", "Drug resistant Mycobacteria Tuberculosis", "Effector Cell", "Epitopes", "Generations", "Goals", "HLA-A gene", "HLA-B Antigens", "Human", "Immune", "Immunity", "Immunization", "Immunodominant Epitopes", "Immunologist", "Incidence", "Infection", "Lung", "Modeling", "Morbidity - disease rate", "Mucous Membrane", "Multi-Drug Resistance", "Mus", "Mycobacterium tuberculosis", "Mycobacterium tuberculosis antigens", "Peptides", "Population", "Positioning Attribute", "Pre-Clinical Model", "Predisposition", "Publishing", "Quality of life", "Research", "Respiratory System", "Route", "Severe Acute Respiratory Syndrome", "Site", "Subunit Vaccines", "Surface", "T cell response", "T memory cell", "T-Lymphocyte Epitopes", "Testing", "Tissues", "Transgenic Mice", "Transgenic Organisms", "Tuberculosis", "Tuberculosis Vaccines", "Vaccinated", "Vaccination", "Vaccine Design", "Vaccines", "Veterans", "Virulent", "Virus", "Work", "clinical practice", "cost", "density", "design", "flu", "high throughput screening", "humanized mouse", "immunogenic", "improved", "in vivo", "innovation", "mortality", "mouse model", "multidisciplinary", "nanoparticle", "next generation", "novel", "novel vaccines", "pathogen", "pre-clinical", "preclinical study", "response", "transmission process", "vaccine delivery", "vector" ], "approved": true } }, { "type": "Grant", "id": "8452", "attributes": { "award_id": "1U01DD001290-01", "title": "Colorado SEED Component A & Component B", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-07-01", "end_date": "2026-06-30", "award_amount": 570172, "principal_investigator": { "id": 24217, "first_name": "CAROLYN G", "last_name": "DIGUISEPPI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children's core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The NC SEED Team in combination with the SEED Network's collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in North Carolina and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8708", "attributes": { "award_id": "1R03OH012215-01", "title": "COVID-19 Exposure, Response, Physical and Mental Health Sequelae among Nurses in New York State", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 24486, "first_name": "Maria", "last_name": "Lioce", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-01", "end_date": "2023-08-30", "award_amount": 80724, "principal_investigator": { "id": 24491, "first_name": "Marlene", "last_name": "Camacho", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 815, "ror": "https://ror.org/0041qmd21", "name": "SUNY Downstate Medical Center", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 815, "ror": "https://ror.org/0041qmd21", "name": "SUNY Downstate Medical Center", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Title: COVID-19 Exposure, Response, Physical and Mental Health Sequalae among Nurses in New York State Project Summary Since the declaration of the COVID-19 pandemic, there have been over 7.6 million COVID-19 cases and over 214,000 deaths in the United States (US). Simultaneously, the physical and mental health impacts of health care workers managing the COVID-19 pandemic (frontline workers) has been increasingly documented, and include increased rates of depression, anxiety, post-traumatic stress disorder, and COVID-19 infection. Associations between individual-level and organizational-level characteristics on risk of COVID-19 infection and mental health outcomes, however, are under explored among frontline nurses. To address these gaps, this project will 1) evaluate the associations between COVID-19 related burnout, coping strategies, on mental health symptoms 2) examine the impact of organizational-level factors on report of COVID-19 symptoms and diagnosis and 3) identify how individual and organizational-level protective factors may buffer adverse mental health outcomes. To accomplish these aims, we will leverage our significant expertise in COVID-19 and occupation health disease disparities research, community-engaged and mixed-method approaches, and our partnership with the PEF Union at the University Hospital of Brooklyn, to recruit 2,000 frontline nurses in New York State to complete a cross-sectional online survey, as well as in-depth qualitative interviews in a subset (N=100) to provide a mixed method dataset of COVID-19 exposures and impacts among a COVID-19 vulnerable occupational group. In this proposed project, we seek to address several key needs as identified by nurses through our union partnerships, including nurse-specific data on inadequate access and training on PPE use, mental health impacts (depression, anxiety, post-traumatic stress disorder), quantitative and qualitative data on how nurses are coping during the COVID-19 pandemic period. Through our study, we will address the NORA “Healthcare and Social Assistance” sector (62) and the “Healthy Work Design and Well-Being Program” cross-sector. Further, these research questions will be examined within the context of the New York State nursing workforce, which was the early epicenter of the US COVID-19 pandemic and currently has the 4th highest number of COVID-19 cases and the highest number of COVID-19 deaths. Findings from this study will contribute to the development of multilevel organizational strategies to support frontline workers by elucidating factors associated with COVID-19 stress and physical and mental health and identifying modifiable factors to improve well-being among vulnerable occupational groups.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4877", "attributes": { "award_id": "NNX11AG68G", "title": "The U.S. Antarctic Meteorite Program has been one of the most successful endeavors in the history of meteoritics and planetary science. Through the 2009-2010 field season, -19,700 meteorites have been recovered. These meteorites have produced fundamental", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2011-01-03", "end_date": "2017-06-30", "award_amount": 0, "principal_investigator": { "id": 16929, "first_name": "CATHERINE", "last_name": "CORRIGAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": null, "abstract": "The U.S. Antarctic Meteorite Program has been one of the most successful endeavors in the history of meteoritics and planetary science. Through the 2009-2010 field season, -19,700 meteorites have been recovered. These meteorites have produced fundamental", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 4, "pages": 1397, "count": 13961 } } }