Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=4&sort=funder
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=funder", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=funder", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=5&sort=funder", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=funder" }, "data": [ { "type": "Grant", "id": "5397", "attributes": { "award_id": "0646308", "title": "Managing the 19 Million Specimen Resource of the NMNH/NSF Antarctic Marine Invertebrate Collection to Meet the Needs of 21st Century Research, Resource Management and Education", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "Major Research Instrumentation" ], "program_reference_codes": [], "program_officials": [ { "id": 18883, "first_name": "Roberta", "last_name": "Marinelli", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2007-08-01", "end_date": "2010-08-31", "award_amount": 497318, "principal_investigator": { "id": 18885, "first_name": "Rafael", "last_name": "Lemaitre", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 711, "ror": "https://ror.org/01pp8nd67", "name": "Smithsonian Institution", "address": "", "city": "", "state": "DC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18884, "first_name": "Myroslaw G", "last_name": "Harasewych", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 711, "ror": "https://ror.org/01pp8nd67", "name": "Smithsonian Institution", "address": "", "city": "", "state": "DC", "zip": "", "country": "United States", "approved": true }, "abstract": "The USAP collection with its nearly 19 million specimens is the basis of current taxonomic knowledge of Antarctic marine invertebrates, and is part of the U.S. Polar research infrastructure. Support is needed to modernize collection management of the USAP holdings, enhance associated data, and expedite data entry to develop the tremendous potential of this valuable resource. Since 1963 the Smithsonian Institution has served as the national archiving and distribution center for invertebrate specimens and associated data collected during the United States Antarctic Program (USAP). The increased demand for modern information on Antarctic marine invertebrates requires professional management, curation, and maintenance of the collection. Support is requested to transform the USAP collection and associated data into a modern resource, primarily web-based, easily available to a vast and diverse audience (e.g., general public, policy makers, conservation groups) as well as making it a useful tool for scholars. This project will be part of the upcoming International Polar Year (IPY) pan-institutional activities of the Smithsonian. The web site will facilitate and accelerate the sharing of information for educational purposes, a variety of scientific analyses, mapping of taxa distributions, biogeographical studies, and provide policy makers with key information useful for biological conservation. The site will be linked to NMNH education programs, and the Ocean Web Portal currently part of the ongoing $72-million Ocean Initiative (http://www.mnh.si.edu/ocean/). The site will also be linked to NSF OPP resources and activities; and the Ocean Biogeographic Information System (OBIS) (http://www.iobis.org), the data component of the Census of Antarctic Marine Life (CAML) (http://www.caml.aq/). The scientific community at large will be encouraged to use the USAP collection through a proposed Antarctic Curator-in-Residence program. These experts will provide specialized information to the NMNH-IZ database, while simultaneously populating the Antarctic Invertebrate Web Site. A work study program will be implemented to train undergraduate and graduate students, including underrepresented groups, in modern collection management practices and collections-based research. All USAP specimens will continue to be accessible to qualified researchers on- or off-site under formal loan agreements. Acquisition of scientifically valuable specimens from new Antarctic research initiatives, types, vouchers, including CAML bar-coding vouchers and the Palmer LTER samples, will continue to be a priority. Specimens from several large and valuable Antarctic collections (echinoderms, crustaceans and nemerteans) from 30+ years overdue loans to now inactive or deceased taxonomists, will be retrieved.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4762", "attributes": { "award_id": "1259496", "title": "High-Achievers Scholarship Program in Computer Science and Mathematics", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "S-STEM-Schlr Sci Tech Eng&Math" ], "program_reference_codes": [], "program_officials": [], "start_date": "2013-09-01", "end_date": "2018-01-31", "award_amount": 620750, "principal_investigator": { "id": 16512, "first_name": "Rahman", "last_name": "Tashakkori", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 426, "ror": "https://ror.org/051m4vc48", "name": "Appalachian State University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 16508, "first_name": "James T", "last_name": "Wilkes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 16509, "first_name": "Cindy", "last_name": "Norris", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 16510, "first_name": "Mark C", "last_name": "Ginn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 16511, "first_name": "Vicky W", "last_name": "Klima", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 426, "ror": "https://ror.org/051m4vc48", "name": "Appalachian State University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "The S-STEM program, The High-Achievers Scholarship Program in Computer Science and Mathematics, at Appalachian State University (ASU) increases the high technology workforce and the number of Computer Science and Mathematic's students pursuing graduate degrees by increasing educational opportunities for economically disadvantaged students with the potential to succeed. The program increases academic opportunities for students from the Appalachia region in multiple ways, by improving the support infrastructure for all Computer Science and Mathematics students, establishing connections with regional high technology industry, providing leadership training opportunities, and engaging students in research.\n\nThe intellectual merits of this program include: 1) It enables on average 21 academically talented, financially disadvantaged scholars per year to make progress toward gaining undergraduate or graduate degrees in two STEM fields; 2) It includes a STEM seminar that initiates community building, mentoring, and research activities, supplemented with value-added components such as leadership workshops and mentoring relationships with previous ASU S-STEM scholars who have graduated; 3) It supports scholar participation in faculty mentored research projects and the dissemination of results, including conference publications and presentations.\n\nThe broader impacts of this program include: 1) Enhancing educational opportunities for disadvantaged students from the Appalachian region; 2) Increasing student support services for all STEM students at ASU; 3) Contributing to the economic development of the Appalachian region and North Carolina through increasing STEM workforce capacity.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5215", "attributes": { "award_id": "0919149", "title": "Collaborative Research: Updating the U.S. Supreme Court Judicial Database", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "LSS-Law And Social Sciences" ], "program_reference_codes": [], "program_officials": [], "start_date": "2009-09-01", "end_date": "2013-08-31", "award_amount": 259577, "principal_investigator": { "id": 18451, "first_name": "Jeffrey", "last_name": "Segal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 578, "ror": "", "name": "SUNY at Stony Brook", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 578, "ror": "", "name": "SUNY at Stony Brook", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded under the American Recovery and Reinvestment Act of 2009\n(Public Law 111-5).\"\n\nFor two decades now, virtually all systematic analysis of the contemporary Supreme Court and its members has relied on Harold J. Spaeth's U.S. Supreme Court Judicial Database. This holds for research conducted by social scientists and, increasingly, by legal academics; and it holds for quantitative and qualitative studies, as well as those more descriptive in nature. In fact, several inventories of peer-reviewed journals show that it is the rare article on the Court that derives its data from an alternative source. Monographs published by top presses also regularly rely on the Database, and the many numerical studies of the Court receiving public attention in recent years have made liberal use of the data it houses. Spaeth's product is one of those rare creatures in the law and social science world: an invention that has substantially advanced a large area of study. Without question, the Database has empowered scholars in many disciplines to conduct original, path-breaking research of the highest intellectual merit.\n\nAnd yet, however invaluable the Database, it is now starting to show its age. Along these lines, we see two major sets of issues. First, for many scholars and their students the Database is diffcult to use. Second, the Database|with its emphasis on the modern (post-1946) Court has not kept pace with scholarly interests. Historical institutionalism and its various subsets have pushed scholars to broaden their time horizons. Within the field of public law, analysts have created a veritable cottage industry devoted to studies of the Court of the 19th and early 20th centuries. Even judicial specialists who ground their work in the 21st century are beginning to apply modern social science methodologies to historical data, with the goals of testing theories of institutional development and illuminating current-day practices and patterns. \n\nWith prior support from the National Science Foundation, we have addressed the first concern and brought the Database in line with 21st century technology. We now address address the second issue. Specifically, we broaden the Database's scope by adding many more cases: the 19,675 resolved between 1792, the year of the Court's first published decision and 1946, the earliest year in the current Database. Our hope is that systematic, historical data on the Court will create an even more valuable a public, multi-user Database that will stimulate scholars and their students to explore new avenues of inquiry, as well as to revisit enduring questions that have yet to be addressed with reliable and valid data. In short, the project not only facilitates scholarship of the highest level of intellectual merit; it also has a broader impact on the community of scholars studying the Court by providing a highly reliable, comprehensive, and adaptable Database.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5444", "attributes": { "award_id": "0554749", "title": "U.S. Japan Workshop on Symbiotic Nitrogen Fixation", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Catalyzing New Intl Collab" ], "program_reference_codes": [], "program_officials": [], "start_date": "2006-03-15", "end_date": "2009-02-28", "award_amount": 52800, "principal_investigator": { "id": 18997, "first_name": "K. Dale", "last_name": "Noel", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 439, "ror": "https://ror.org/04gr4te78", "name": "Marquette University", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 439, "ror": "https://ror.org/04gr4te78", "name": "Marquette University", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "OISE-0554749 \n(K. Dale Noel, Marquette University)\nU.S.-Japan Workshop on Symbiotic Nitrogen Fixation\n\n\nThis proposal, from Dale Noel of Marquette University, will organize a U.S.-Japan workshop titled Genomics, Molecular Mechanisms and Evolution of Symbiotic Nitrogen Fixation. The workshop, jointly organized with Professor Shigeyuki Tajima of Kagawa University, will take place outside Tokyo, Japan on August 15-19, 2006. Sixteen U.S. participants, including at least five graduate students and postdoctoral researchers, will join 11 Japanese researchers and their students for the meeting. Meeting sessions will explore the following topics: 1) bacterial genetic and genomic-proteomic approaches to understanding symbiosis; 2) evolution and horizontal phylogenetic distribution of plant-microbe associations; 3) biochemistry and molecular interactions during symbiotic development; 4) molecular genetics and genomics-proteomics of two model legumes; and 5) from model legumes to soybean and other crop legumes.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4899", "attributes": { "award_id": "1060208", "title": "Origin of Millennial-scale Climate Signals in the Northwestern Subtropical Atlantic", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "Marine Geology and Geophysics" ], "program_reference_codes": [], "program_officials": [ { "id": 17637, "first_name": "Candace", "last_name": "Major", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-08-01", "end_date": "2013-10-31", "award_amount": 166976, "principal_investigator": { "id": 17638, "first_name": "Katharina", "last_name": "Billups", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 442, "ror": "https://ror.org/01sbq1a82", "name": "University of Delaware", "address": "", "city": "", "state": "DE", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 442, "ror": "https://ror.org/01sbq1a82", "name": "University of Delaware", "address": "", "city": "", "state": "DE", "zip": "", "country": "United States", "approved": true }, "abstract": "The question of whether millennial-scale climate changes are related to changes in the Earth's orbit (and thus the timing and distribution of solar influence on the Earth's surface) is decades old, but remains the subject of debate in the climate change science community. This research, led by a scientist at the University of Delaware, investigates how short-term climate variability evolved as the periodicity of orbital precession has changed through the Pleistocene, focusing on the last 900,000 years. The central hypothesis is that millennial-scale climate signals in the northwestern subtropical Atlantic are linked to external driving factors, specifically the fourth harmonic of precession. If tropical insolation forcing controls millennial-scale variability, then there should be a reduction in the spectral power of the fourth harmonic (4,800 year) peak as the 19,000 year precession frequency disappears after about 340,000 years ago. \n\nAs a prerequisite for testing the hypothesis, the work will fill a key gap in the stable oxygen isotope record from the Blake-Bahama Outer Ridge, completing a 1.4 million year long planktonic foraminifer stable isotope record from the Blake Outer Ridge. This fulfills a primary objective of Ocean Drilling Program Leg 172. \n\nIn terms of broader impacts, the research will provide important information about natural climate variability, and results will be disseminated through public presentations by the lead scientist. Funding also supports a Master's degree student.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4863", "attributes": { "award_id": "1116374", "title": "WORKSHOP: HCC: VL/HCC 2011 Doctoral Consortium", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)", "HCC-Human-Centered Computing" ], "program_reference_codes": [], "program_officials": [ { "id": 16891, "first_name": "Ephraim", "last_name": "Glinert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-06-01", "end_date": "2012-05-31", "award_amount": 20903, "principal_investigator": { "id": 16892, "first_name": "Christopher", "last_name": "Scaffidi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 154, "ror": "https://ror.org/00ysfqy60", "name": "Oregon State University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 154, "ror": "https://ror.org/00ysfqy60", "name": "Oregon State University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "This is funding to support a Doctoral Consortium (workshop) for about 10-14 graduate students, along with a panel of 4-5 distinguished research faculty mentors, which will take place in conjunction with the 2011 IEEE Symposium on Visual Languages and Human-Centric Computing (VL/HCC 2011), to be held September 19-21, 2011, in Pittsburgh, and sponsored by the IEEE Computer Society. The long-running VL/HCC series occupies a unique niche among HCI and Programming Language conferences, in that it focuses specifically on how to help end users successfully develop and use software. Recent advances in computing have led to continually deeper integration between computers and human society. People now swim in a \"sea\" of socio-technical systems that synthesize large numbers of contributing users with vast amounts of source code. Examples include social media systems, open source repositories, online marketplaces and massively multiplayer online games. Yet as the socio-technical systems in this sea have grown in complexity, they have become increasingly difficult for end users to understand and direct toward productive ends. Thus, when users put data into a system they may be unable to anticipate and control how their data will be used by other people or by software in the system; when users take actions in the system they often cannot foresee and manage unintended effects on other users, software, or the system as a whole, particularly because the system's software often contains defects. These problems are further complicated by the fact that different users simultaneously might take actions toward differing goals, while autonomous software such as agents might meanwhile also take actions toward goals of their own. These and similar problems reflect a fundamental lack of sufficient methods, models and tools to help end users visualize, analyze, tailor, and manage large socio-technical systems. At a deeper level, insufficient theory is available for predicting the complicated, unstable, sometimes-emergent behavior that results when large numbers of diverse, unpredictable humans are coupled to unreliable software.\n\nThis year's VL/HCC Doctoral Consortium, the ninth to be funded by NSF in this series, will focus on advancing knowledge and understanding of solutions to these problems. The workshop will bring together and build community among young researchers working on different aspects of these problems from the perspectives of diverse fields including computer science, the social sciences, and education. It will guide the work of these new researchers by providing an opportunity for experts in the research field (as well as their peers) to give them advice, in that student participants will make formal presentations of their work during the workshop and will receive feedback from a faculty panel. The feedback is geared to helping students understand and articulate how their work is positioned relative to other human-computer interaction research, whether their topics are adequately focused for thesis research projects, whether their methods are correctly chosen and applied, and whether the results are appropriately analyzed and presented. As in prior years the VL/HCC 2011 Doctoral Consortium will be part of the regular conference program. A 2-page extended abstract of each participant's work will be published in the conference proceedings. More information about the VL/HCC conference may be found at http://www.cs.cmu.edu/~vlhcc2011. \n\nBroader Impacts: The workshop will help shape ongoing and future research projects aimed at alleviating a pressing problem of relevance to a great many people within our society. This event will promote discovery and learning, by encouraging the student researchers to explore a difficult and challenging open problem, through involvement of a panel of well-known researchers whose task is to provide constructive feedback, and through inclusion of other conference participants who will also learn from and provide additional feedback to the students and to each other. The PI and the members of the organizing committee will make special efforts to attract a diverse and interdisciplinary group of student participants, with special attention paid to recruitment of women and minorities. The PI expects that most of the students supported by this award will come from U.S. universities but as in past years, due to the highly international make-up of the research community, a few non-U.S. students may be invited to participate as well.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5367", "attributes": { "award_id": "0724719", "title": "NeXtworking 2007 Workshop on Future Internet Architecture", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Networking Technology and Syst" ], "program_reference_codes": [], "program_officials": [ { "id": 18816, "first_name": "Darleen", "last_name": "Fisher", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2007-04-15", "end_date": "2008-03-31", "award_amount": 30000, "principal_investigator": { "id": 18817, "first_name": "Jennifer", "last_name": "Rexford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 191, "ror": "https://ror.org/00hx57361", "name": "Princeton University", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 191, "ror": "https://ror.org/00hx57361", "name": "Princeton University", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "This award funds a joint COST-IST (EU) and NSF (USA) NeXtworking 2007 Workshop on Future Internet Architecture held on April 19-20, 2007, in Berlin, Germany. There are three main objectives for the workshop:\n.\tIdentifying networking research challenges: The workshop focuses on identifying the main research challenges that must be addressed to lead to a future Internet architecture that addresses the many challenges of today's networks and the promising capabilities of tomorrow's technologies.\n.\tIdentifying requirements for experimental facilities: A closely related goal is to investigate the role of experimental facilities in supporting the research and the capabilities these facilities should have, as well as documenting the strengths and limitations of existing research testbeds.\n.\tFacilitating collaboration between EU and US researchers: By bringing together researchers from the EU and US, the workshop will build stronger ties for joint research including organizing joint efforts on the design, and particularly the federation, of future experimental facilities. \nThe workshop targets key research areas in networking represented by premier researchers from the EU and USA, with an emphasis on the needs of future network architectures rather than summaries of mature research results. The workshop organizers are Christophe Diot (Thomson), Serge Fdida (U. Paris), Anja Feldmann (TU-Berlin), Jennifer Rexford (Princeton University), and Ioannis Stavrakakis (University of Athens), Jennifer Rexford will handle the NSF funding and Scott Kirkpatrick is handling the 30,000 Euros that COST is providing for the workshop. After the conclusion of the workshop, the organizing committee will furnish a report to the COST-IST (EU) and NSF (USA) and will make it publicly available to participants and others via the workshop Web site and any relevant funding-agency Web sites.\n\nIntellectual Merit\nThe workshop focuses on the intellectual challenges of designing a future Internet architecture that is worthy of society's trust (in terms of important metrics such as scalability, reliability, security, manageability, usability, and other so-called X-ities) and expands the capabilities available to end users (including support for mobility and large numbers of wireless and sensor devices). At the NSF, these research challenges lie at the heart of the FIND (Future INternet Design) initiative. In addition, the workshop will include discussion of tools and techniques for evaluating new architectural ideas, including modeling, simulation and experimental tools and techniques for connecting multiple experimental facilities to enable larger-scale evaluation. \n\nBroader Impact: The importance of the Internet for the economic, political, and social well-being of the nation, and the world, cannot be overstated. The workshop will play an important role in outlining a larger research agenda for the design of a future Internet. In addition, the workshop will enable a strong collaboration between EU and US researchers in networking research and the design and operation of global experimental facilities for evaluating new network architectures.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5191", "attributes": { "award_id": "0920357", "title": "The role of Protocadherin-19 in brain morphogenesis", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Animal Developmental Mechanism" ], "program_reference_codes": [], "program_officials": [ { "id": 18398, "first_name": "Steven", "last_name": "Klein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2009-07-01", "end_date": "2013-06-30", "award_amount": 540000, "principal_investigator": { "id": 18399, "first_name": "James", "last_name": "Jontes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1375, "ror": "", "name": "Ohio State University Research Foundation -DO NOT USE", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\nThe central nervous system (CNS) is a structure of immense complexity and intricacy, whose overall architecture has been conserved throughout vertebrate evolution. The molecular and cellular mechanisms by which the three-dimensional (3D) structure of the CNS is generated during development are not well understood. One of the earliest steps in brain assembly occurs during neurulation, the coordinated movement of cells to form the neural tube, which will give rise to the brain and spinal cord. The Jontes lab has identified an evolutionarily conserved molecule, Protocadherin-19 (Pcdh19), that plays an important role in neurulation. Loss of Pcdh19 function inhibits cell movements that contribute to neurulation, resulting in abnormal brain morphology. The goals of this research are to understand how Pcdh19 regulates cell behavior during neurulation, and the molecular pathways through which Pcdh19 functions. To do this, the Jontes lab uses quantitative in vivo time-lapse microscopy to follow the 3D movements of cells in the developing zebrafish embryo. The results of this research will advance our understanding of the mechanisms of early brain development. The broader scientific and educational goals of this work are to provide a training environment in which students at different levels, particularly those from under-represented groups, will be exposed to sophisticated imaging techniques and quantitative image analysis. In addition, the imaging data that will result from this work will be of high educational value and will be made easily accessible to researchers and teachers.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11051", "attributes": { "award_id": "2235553", "title": "Roles of galectins in viral infection of mucosal epithelia using the zebrafish model system", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [ { "id": 5064, "first_name": "Mamta", "last_name": "Rawat", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-03-01", "end_date": "2026-02-28", "award_amount": 666071, "principal_investigator": { "id": 27021, "first_name": "Gerardo", "last_name": "Vasta", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 262, "ror": "", "name": "University of Maryland at Baltimore", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Viral diseases can have a severe impact on both human and animal populations, including farmed and natural fish populations. Viruses such as influenza A virus, rabies, respiratory syncytial virus, coronaviruses (COVID19), use a wide variety of strategies to attach to and enter their hosts’ epithelial cells. In many of these examples, however, the detailed mechanisms still remain unclear and urgent research is needed to gain the key information that would enable the development of innovative preventive and therapeutic strategies for viral disease. This research project uses the zebrafish model system to address questions about the mechanisms involved in viral infection, with focus on the role(s) of sugar-binding proteins (galectins) in viral adhesion. Several galectin types are present in both fish and humans, and function in defense against viral infection. A recent study by the investigators revealed that a particular galectin type (galectin-9) promotes viral infectivity. These observations established a new paradigm for the role of galectins as anti-viral defense factors, as they suggest that some viruses have evolved to “hijack” galectins to facilitate viral host entry. By the use of innovative experimental approaches and state-of-the-art molecular tools, this project is aimed at elucidating the molecular mechanisms by which galectin-9 promotes viral infection. The research will provide critical and useful information for viral infections relevant to human and veterinary medicine, including commercial aquaculture. Importantly, these studies will also contribute to the education and hands-on training of graduate, undergraduate, and high school students, including students from underrepresented minorities. \n\nThe infectious hematopoietic necrosis virus (IHNV) is one of the most important fish pathogens in natural and farmed populations worldwide. Environmental stress and high-density aquaculture can lead to catastrophic IHNV outbreaks. Infection by IHNV involves interaction of the viral envelope glycoprotein spikes with glycoprotein receptor(s) on the fish epithelia, but the mechanisms remain unknown. The investigator’s lab addresses structural/functional aspects of sugar-binding proteins expressed by the host, such as galectins, in infectious disease using both murine and non-mammalian models, such as zebrafish. Several structurally different galectin types have been described (e.g. galectin-1, Gal1; Gal3; and Gal9). While the zebrafish Gal1 and Gal3 hinder IHNV viral adhesion, Gal9, which houses two sugar-recognition domains, promotes viral infectivity. This led to the hypothesis that zebrafish Gal9 enhances viral attachment by crosslinking the viral envelope glycoprotein to fish epithelial glycans, and that under environmental stress the protective role of epidermal mucus is diminished. The hypothesis will be tested by investigating though state-of-the-art biochemical, molecular, and genetic experimental approaches the mechanism(s) involved in Gal9-mediated enhancement of IHNV entry into the host epithelial cell, and potential increase of viral replication, the epidermal mucus’ protective role, and the detrimental effect of stressful environmental conditions. This research will be examine the long-held concept of galectins as defense factors against infectious disease, and will unravel basic infection mechanisms pertinent to other enveloped viruses (e.g. influenza, rabies, and coronavirus) of human and veterinary relevance.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4779", "attributes": { "award_id": "1358171", "title": "Representation Theory and applications to Combinatorics, Geometry and Quantum Physics", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "ALGEBRA,NUMBER THEORY,AND COM" ], "program_reference_codes": [], "program_officials": [ { "id": 16581, "first_name": "Andrew", "last_name": "Pollington", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2013-12-01", "end_date": "2015-11-30", "award_amount": 30000, "principal_investigator": { "id": 16582, "first_name": "Pavel", "last_name": "Etingof", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 210, "ror": "https://ror.org/042nb2s44", "name": "Massachusetts Institute of Technology", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The conference 'Representation Theory and Applications to Combinatorics, Geometry and Quantum Physics' will be held on December 13 through 19, 2013, at the Independent University of Moscow in Russia. It will be a major gathering of the leading mathematicians and young scholars whose work fits in the realm of representation theory. The conference has a broad scope and it aims to present some of the most important recent developments and techniques in this field, in particular the rich web of interconnections between representation theory, combinatorics, geometry, and physics, which has emerged in recent years and has greatly helped to advance each of these fields. The topics to be covered in the conference include algebraic groups, geometric representation theory, vertex algebras, infinite dimensional Lie algebras, combinatorics of plane partitions, conformal field theory and enumerative algebraic geometry. Many talks will involve applications of representation theory to mathematical physics, combinatorics and algebraic geometry. The organizers expect the conference to be a major gathering of researchers in these fields and one of the most important mathematical events to take place in Moscow in the last few years. We expect that it will attract many graduate students and postdoctoral fellows, especially from the USA.\n\nIn quantum physics, which describes the world of small objects (such as atoms, electrons, nuclei, etc) the state of a physical system is random and not definitively determined, unlike classical physics. In other words, states are no longer definite points of the classical space of states, but rather functions on the space of positions of the system, whose squared magnitude represents the chance the system will be found in that particular state. Such functions can be added and multiplied by numbers; that is, they form what is called a linear space. Symmetries of the system act by linear transformations of this space and therefore play an important role in studying quantum systems. The part of mathematics which studies actions of symmetries in linear spaces is called representation theory since we represent symmetries by linear transformations. Representation theory is thus extremely useful in quantum physics and other areas of physics, while physics, in turn, constantly provides deep insights into representation theory and other areas of mathematics. For example, in recent years the development of the representation theory of infinite-dimensional symmetries, coming from quantum field theory, has been an active area of research. During the conference leading mathematicians and mathematical physicists, many from the United States, will discuss the connections between representation theory and related fields in mathematics, as well as the connections to physics, especially in light of recent breakthroughs. The conference will be very useful for young mathematicians and graduate students who will attend the conference. The money from this award will support the travel and local expenses of US-based speakers and participants. Conference materials will be disseminated through the conference website http://bogomolov-lab.ru/rep2013/, which will allow the ideas presented at the conference to be accessed by a wide audience in the US and around the world. NSF support from this award will be advertised on the website, and US-based participants will be able to apply for this support.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 4, "pages": 1405, "count": 14046 } } }