Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=3&sort=-award_id
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-award_id", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-award_id", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-award_id", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=2&sort=-award_id" }, "data": [ { "type": "Grant", "id": "8092", "attributes": { "award_id": "7U01AG062370-03", "title": "Elucidating the Necessary Components and Mechanisms of Cognitive Training", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20585, "first_name": "Dana Jeffrey", "last_name": "Plude", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-02-15", "end_date": "2022-11-30", "award_amount": 802633, "principal_investigator": { "id": 23977, "first_name": "Lesley A", "last_name": "Ross", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 290, "ror": "https://ror.org/037s24f05", "name": "Clemson University", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 290, "ror": "https://ror.org/037s24f05", "name": "Clemson University", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Title: Elucidating the Necessary Components and Mechanisms of Cognitive Training Project Dates: June 1, 2020-Mary 31, 2021 Project Number: U01AG062370 The continued goal of this project (grant title: Elucidating the Necessary Components and Mechanisms of Cognitive Training, U01AG062370) and associated supplement is to develop and evaluate the protocol to examine behavioral and neural mechanisms underlying multiple cognitive training programs in older adults. Dr. Ross relocated to Clemson University and seeks approval to move the grant to Clemson with subcontracts returned to Penn State, Einstein, and UAB to complete the work as originally planned. The overall goal and aims of the project are the same with changes outlined below primarily due to COVID-19. Changes due to PI move to Clemson: None. Dr. Ross has attained an Endowed Chair position in Aging and Cognition. This position includes no teaching responsibilities for two years which allows her to focus on research. Additionally, the Dr. Ross will maintain a faculty affiliate position at Penn State ensuring maintained access to Penn State systems. Dr. Ross holds several standing meetings with study staff and coinvestigators via zoom to ensure clear communication. These included weekly lab meetings to review study progress and weekly joint staff meetings with co- investigators and staff regarding any project difficulties. Additionally, all staff meet individually with Dr. Ross every other week and with the Center for Healthy Aging’s administrative leader monthly to address study or personnel issues. Dr. Sliwinski (mPI) will continue to oversee the Penn State subcontract as site PI. Given these multiple lines of communication which are already being implemented, Dr. Ross will be able to oversee the study from Clemson University. Changes due to COVID-19: The original project involved four in-person data collection visits and two additional in-person visits for the MRI subsample. Due to COVID-19, we redesigned all study materials and re-budgeted for additional equipment to allow us to collect all data remotely. In order facilitate the project moving forward, especially given concerns about possible additional waves of COVID in the winter of 2020-2021, we are moving to remote data collection. This decision was reached in consultation, and with approval, by NIA. The changes will allow us to collect cognitive, psychosocial, everyday functioning and self-reported sensory functioning using study-provided laptops at baseline, posttest, and follow-up. The smartphone data collection process has not changed and still includes cognitive and psychosocial measures administered daily throughout the study period. We are using the NIA-funded M2C2 mobile phone platform for daily assessments (Ambulatory Methods for Measuring Cognitive Change; U2C AG060408) which has been piloted using multiple phones over the last eight months. We have also partnered with established online assessment and training companies (Posit Science, TestMyBrain, and iFunction) to include established remote data collection assessments as well as newer ones developed or adapted for the purpose of this study (DECA, ANT). This provides significant overlap across new and established assessments in case there are technical difficulties with the newer remote data collection. Other changes: Given the complexity of remote data collection, we have included Dr. Christine Phillips as a Co-Investigator on the project. Dr. Phillips is a research assistant professor at Clemson and has worked with Dr. Ross for over 6 years. She will assist Dr. Ross with overseeing all aspects of the study.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15427", "attributes": { "award_id": "7RF1NS131165-02", "title": "Validation of Neuropilin-1 Receptor Signaling in Nociceptive Processing", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 12056, "first_name": "DURGA PRASANNA", "last_name": "Mohapatra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-01-01", "end_date": "2026-08-31", "award_amount": 1926350, "principal_investigator": { "id": 24586, "first_name": "Rajesh", "last_name": "Khanna", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1755, "ror": "", "name": "REGULONIX, LLC", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "Nociceptive pain is a protective response to harmful stimuli that is necessary to survival while nociplastic pain represents altered nociception arising from a sensitization of peripheral nociceptor neurons leading to subthreshold inputs eliciting a pain response. While studying a potential role for SARS-CoV-2 spike ^protein in pain, we identified Neuropilin 1 (NRP1) as a key receptor mediating the transduction of vascular endothelial growth factor-A (VEGFA) signaling to sensitize sensory neurons in models of nociplastic pain. In models of nerve injury pain, vascular endothelial growth factor-A (VEGFA) – an angiogenic factor – binds NRP1 and induces mechanical allodynia and thermal hyperalgesia. Pharmacological antagonism of NRP1 blocked VEGFA induced pain-like behaviors. This work demonstrated that NRP1 could be a novel therapeutic target with the potential to reverse chronic pain. Mechanistically, NRP1 sits upstream of a cytosolic protein – the collapsin response mediator protein 2 (CRMP2), a dual trafficking regulator of N-type voltage-gated calcium (CaV2.2) as well as voltage-gated sodium channels. We hypothesized that activation of the VEGFA/NRP1/CRMP2/ion channel pathway elicits sensitization of dorsal horn neurons, consequently contributing to neuropathic pain states by enhancing excitatory synaptic input to dorsal spinal cord neurons. In this proposal, we test the hypothesis that interfering with VEGFA binding to NRP1 initiates an intracellular signaling cascade that, through CRMP2, leads to a decrease in sodium and calcium channel functional activity to decrease nociceptor activity culminating in reduced pain-like behaviors. We plan to test our hypothesis by using two chronic pain models to answer the following questions: 1. Does NRP1 signaling induce nociceptor sensitization and chronic hypersensitivity via CRMP2? 2. How does NRP1 signaling affect acute and chronic pain? 3. Are the behavioral effects of NRP1 mediated by neurons or microglia in the DRG? Completion of the proposed studies will allow: (i) validation of a novel target of chronic pain, (ii) use two chronic pain models to explore the breadth of applicability, and (iii) provide important information for development of a next generation of mechanism-based chronic pain medications. Overall, completion of these experiments will validate the role of NRP1 in nociceptive processing and will open opportunities for future therapeutic targeting of NRP1 for chronic pain treatment.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11472", "attributes": { "award_id": "7R56HL164737-02", "title": "Efficacy of a novel web-based physical activity intervention designed to promote adherence to physical activity guidelines in adults with obesity", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 8616, "first_name": "Laurie Friedman", "last_name": "Donze", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-09", "end_date": "2023-08-31", "award_amount": 761582, "principal_investigator": { "id": 27523, "first_name": "Jacob Kigo", "last_name": "Kariuki", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Title: Efficacy of a novel web-based physical activity intervention designed to promote adherence to physical activity guidelines in adults with obesity Funding organization: The National Heart, Lung, and Blood Institute (NHLBI) Grant type: R01 Date submitted: Oct 2, 2021 Amount requested: $3,167,589 PI: Kariuki Jacob, PhD Co-investigators: Lora E. Burke, PhD, MPH; Bethany Gibbs, PhD; Erick Erickson, PhD; Andrea Kriska. Consultants: David Ogutu, BS Project Summary/Abstract The National Guidelines recommend that all American adults achieve ≥150 min of moderate to vigorous intensity physical activity weekly. Yet, adherence to the Guidelines is low, with only 24% of adults attaining the recommended physical activity (PA). The low levels of PA increase the risk cardiometabolic disease, especially among individuals with obesity. Although any increase in PA can reduce the risk, these individuals face complex weight-related impediments including stigma, embarrassment, poor fitness, and low self-efficacy that reduce their engagement in PA. To mitigate these barriers, web-based PA interventions have been developed, but their efficacy is often limited by lack of behavioral coaching and generic content that does not address barriers experienced by those with obesity. Our research team and others have reported that culturally diverse individuals with obesity prefer PA programs that are convenient, fun to engage in, and feature people to whom they can relate especially in body size, fitness level, and age. Yet, there is a paucity of PA interventions intentionally designed to incorporate these preferences. In our prior work, we sought the input of individuals with overweight/obesity to inform the development of a technology-based Physical Activity for The Heart (PATH) intervention that leverages openly accessible platforms, such as YouTube, to provide workout videos that match the specific preferences expressed in our formative studies and the extant literature. We have successfully beta tested the PATH platform and have demonstrated excellent retention, intervention engagement and preliminary efficacy in our 12-week feasibility studies. In this application, we propose to test the efficacy of PATH in promoting adherence to the PA Guidelines in a diverse sample of inactive adults with obesity. Our long-term goal is to deploy the PATH intervention as a scalable stand-alone program to increase access, reduce time commitment, avoid weight-related stigma, and lessen the impact of unpredictable barriers to PA such as inclement weather or pandemics like COVID-19. We will conduct a 12-month 2-group randomized controlled trial and equally allocate 450 adults to one of the two intervention conditions: Path intervention or attention control. In Aim 1 we will evaluate the efficacy of PATH for improving short- and long-term adherence to the PA Guidelines. In Aim 2 we will compare the effects of the PATH intervention on risk factors for CVD. In the final Aim, we will explore the potential mechanisms of action associated with changes in the PA outcomes. At the end of the study, we will survey user experience and views on the most useful components of the PATH intervention. Our approach is innovative because we leverage freely accessible resources to provide a highly scalable, convenient, fun to engage in PA program that utilizes carefully selected workout videos to help individuals with obesity progress along the PA continuum. This contribution will be significant because PATH could offer a novel, convenient, enjoyable, and highly scalable program that features “similar others” to promote PA in adults with obesity.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15535", "attributes": { "award_id": "7R34MH129542-03", "title": "Adaptation of Critical Time Intervention for Young Adults with Mental Health Challenges in the Transition from Homelessness to Housing", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 32081, "first_name": "Shahrzad", "last_name": "Mavandadi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-15", "end_date": "2025-11-30", "award_amount": 146354, "principal_investigator": { "id": 26858, "first_name": "Sarah Carter", "last_name": "Narendorf", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 167, "ror": "https://ror.org/0190ak572", "name": "New York University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Young adults experiencing homelessness (YAEH) have high prevalence of mental disorders, however, they face unique access barriers to mental health services combined with low recognition of mental health symptoms, leading to low rates of mental health service utilization. The point of transition from homelessness to housing presents a period of opportunity to identify mental health symptoms and connect and engage YAEH into mental health services to reduce symptoms and promote housing stability. The COVID-19 pandemic has heightened mental health symptoms and increased the need for services among YAEH, but it has also resulted in recovery funds to increase housing supports in many communities. There is a critical need to develop interventions that can support YAEH with mental health challenges as they make the transition from homelessness to housing as more supported housing becomes available. Critical Time Intervention (CTI), a structured, time limited case management intervention has demonstrated success with adults with serious mental illness in multiple randomized controlled trials but it has not been tested in YAEH. The goal of this study is to adapt CTI for the context of transition from homelessness to supported housing within the rapid rehousing program, integrating mental health specific content from a young adult treatment model, C4, to develop CTI-YAMH (young adult mental health), and then test the new intervention in a feasibility pilot. Specifically, we aim to: Aim 1: Refine the draft CTI- YAMH intervention (treatment, training and assessment protocols) to ensure the target mechanisms are adequately addressed for stabilizing housing and mental health, utilizing an iterative stakeholder feedback process to finalize the manuals for pilot testing, then Aim 2: Conduct an open trial of the adapted CTI- YAMH intervention to assess the feasibility of randomization procedures, refine outcome measures, assess acceptability, and examine the preliminary signal of impact of the intervention. This innovative study targets a critical point of intervention, the transition from homelessness to housing, for an extremely marginalized group (YAEH), utilizing an innovative adaptation framework, ADAPT-ITT, to systematically adapt CTI in partnership with youth with lived expertise and community providers. The CTI-YAMH intervention aims to support a population with high unmet need for mental health services through a model that can be paired with rapid rehousing, a supportive housing model widely used in communities across the U.S. Results from this R34 study lay the foundation for a fully powered RCT of the CTI-YAMH intervention in a future R01 study.", "keywords": [ "Address", "Administrator", "Adult", "Age", "Anxiety", "COVID-19 pandemic", "Caring", "Case Management", "Case Manager", "Characteristics", "Clinic", "Communities", "Community Health Care", "Continuity of Patient Care", "Coupled", "Development", "Diagnosis", "Effectiveness", "Elements", "Ensure", "Evidence based intervention", "Evidence based practice", "Face", "Feedback", "Focus Groups", "Foundations", "Funding", "Future", "Goals", "Health", "High Prevalence", "Homelessness", "Housing", "Individual", "Institute of Medicine (U.S.)", "Intervention", "Intervention Studies", "Investigational Therapies", "Manuals", "Mental Health", "Mental Health Services", "Mental disorders", "Mentors", "Modeling", "Moods", "National Institute of Mental Health", "Outcome Measure", "Outcomes Research", "Outpatients", "Phase", "Population", "Population Heterogeneity", "Procedures", "Process", "Protocols documentation", "Provider", "Randomized", "Randomized Controlled Trials", "Recommendation", "Recovery", "Recurrence", "Research Priority", "Self Efficacy", "Services", "Signal Transduction", "Social support", "Structure", "Symptoms", "Testing", "Time", "Training", "Trauma", "United States", "Variant", "Work", "Youth", "care coordination", "experience", "family support", "federal policy", "health service use", "housing instability", "improved", "innovation", "marginalized population", "member", "peer support", "person centered", "pilot test", "pilot trial", "preference", "primary outcome", "programs", "reduce symptoms", "service utilization", "severe mental illness", "skill acquisition", "social stigma", "substance use", "success", "supported housing", "therapy design", "therapy development", "working group", "young adult" ], "approved": true } }, { "type": "Grant", "id": "7893", "attributes": { "award_id": "7R34MH116725-04", "title": "Using Open Contest and Neuro-Influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 7803, "first_name": "Gregory", "last_name": "Greenwood", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-03-18", "end_date": "2023-02-28", "award_amount": 212558, "principal_investigator": { "id": 7158, "first_name": "Cui", "last_name": "Yang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1418, "ror": "", "name": "RBHS-SCHOOL OF PUBLIC HEALTH", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1418, "ror": "", "name": "RBHS-SCHOOL OF PUBLIC HEALTH", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "Latinx communities have experienced profound disparities in COVID-19 cases, morbidity, and mortality. With anticipated advances in COVID-19 testing technologies and vaccine development in the next few months, failing to provide equitable access to testing and future vaccination will exacerbate the profound disparities in COVID-19 seen among Latinx communities. Significant gaps in knowledge remain with respect to what are the key modifiable facilitators and barriers associated with COVID-19 testing uptake in Latinx communities and how to engage and build trusting relationships with Latinx communities to develop culturally and linguistically congruent COVID-19 testing programs. This proposal's overarching objectives are (1) to better understand multi-level determinants likely to influence COVID-19 testing access, acceptability, and uptake, and (2) to develop culturally and linguistically congruent COVID-19 testing strategies using crowdsourcing open contests among Latinx communities in Baltimore, MD; Denver, Co; and Tampa Bay, FL. This study team has extensive experience in community engagement, research, and program implementation with Latinx communities. Built upon established collaborations with community partners in each study site, activities proposed in this study include full participation of community partners in research design, implementation, and dissemination. Findings developed through this project will directly inform community-engaged COVID-19 testing programs and as well as targeted strategies to engage racial and ethnic minority communities disproportionately affected by the COVID-19 pandemic. We will actively coordinate and share data and protocols with other grantees, the CDCC, and other research supported by the RADx-UP program.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14693", "attributes": { "award_id": "7R33HD106578-04", "title": "An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 28151, "first_name": "FRANKLIN WILLEM", "last_name": "Yates", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-03-08", "end_date": "2026-06-30", "award_amount": 308796, "principal_investigator": { "id": 24185, "first_name": "Aimalohi", "last_name": "Ahonkhai", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Young people living with HIV (Y-PLWH) have poor adherence to antiretroviral therapy and engagement in HIV care, making HIV the leading cause of death for African adolescents. Depression and psychological distress are much more common among Y-PLWH than in the general population, and are associated with significantly worse adherence to care and treatment when compared to Y-PLWH without these co-morbid conditions. Thus, untreated depression and severe psychological distress are important contributors to poor HIV outcomes in this population. Nigeria is home to the 4th largest HIV population globally and 10% of Y-PLWH, but mental health screening is not routinely conducted in this setting, and less than 10% of those diagnosed have access to evidence-based care. Despite this treatment gap, few interventions have targeted the mental health needs of Y-PLWH in Africa. The World Health Organization recommends that caregivers of Y-PLWH adopt youth- friendly strategies and incorporate psychosocial services to meet their needs, and that task shifting to non- specialized health workers be used to overcome the dearth of trained professionals in low and middle-income countries. Task-shifted problem Solving Therapy (PST) has been effectively used by our team and others to treat both depression and psychological distress using a task-shifted approach. However, PST is an intensive strategy (typically 6-15 weekly sessions) often delivered in-person and poor completion rates are associated with less effectiveness -- a concern further magnified during the current COVID-19 climate. Mobile health technologies may be uniquely suited to surmount some of the obstacles for effective PST delivery in Nigeria and novel digital game-based strategies, can be utilized to promote engagement in mental health interventions on a platform that is compelling for young people. Our team has developed, a preliminary prototype of a theory-grounded game, Change My Story, in which players navigate difficult experiences based on drivers of psychological distress and interact with a virtual environment to choose a narrative path toward the story's conclusion. In this proposal, we will finalize the prototype of Change My Story, and integrate this game into a comprehensive, task-shifted PST intervention delivered via mobile phone to optimize engagement in mental health care. Through the R21 mechanism, we aim to: 1) finalize the Change My Story prototype to address key drivers of psychological distress among Y-PLWH in Nigeria and 2) establish the usability, feasibility, and acceptability of Change My Story among Y-PLWH with psychological distress in Nigeria. Through the R33 mechanism, we aim to 1) conduct a hybrid implementation-effectiveness pilot RCT for 80 Y-PLWH with depression or psychological distress, and compare feasibility, acceptability, engagement, satisfaction and preliminary effectiveness among individuals receiving PST alone or PST with Change My Story, and 2) use the Consolidated Framework for Implementation Research (CFIR) to assess factors influencing engagement, acceptability, and satisfaction along with facilitators and barriers to implementation delivery.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11486", "attributes": { "award_id": "7R25GM146236-02", "title": "Tomorrow's Science Today: Preparing for the Next Pandemic", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-11", "end_date": "2027-06-30", "award_amount": 235187, "principal_investigator": { "id": 10612, "first_name": "Tim M.", "last_name": "Herman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1090, "ror": "https://ror.org/04h7cfr36", "name": "Milwaukee School of Engineering", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 2034, "ror": "", "name": "3D MOLECULAR DESIGNS", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project – Tomorrow’s Science Today: preparing for the next pandemic – will create a professional development experience for high school science teachers focused on infectious diseases and the molecular technologies that are being used to control them. The project consists of two distinct phases. In the first, we will create a variety of hands-on instructional materials – composed of both foam-based schematic models and accurate 3D-printed models of proteins – to bring to life molecular stories of the process of science. We will use a framework that emphasizes how the foundational concepts of molecular biology established in the past (Yesterday’s Science) provides the basis for the amazing technology that has been brought to bear on the current SARS-Cov-2 pandemic (Today’s Science) and also lays the ground-work for even more powerful defenses in the future (Tomorrow’s Science). In the second phase of this project, we will create a professional learning experience in which the project’s instructional materials will be introduced to high school science teachers. The project’s goals are (i) to increase the teachers’ content knowledge regarding the molecular mechanisms of infectious diseases and (ii) to model for the teachers a student-centered active learning pedagogy that values questions over answers. The project features a formal teacher empowerment program in which a small group of veteran teachers are trained to serve as mentors for teachers who are new to the project. High school biology and chemistry teachers will be recruited into this project via presentations and exhibits at state, regional and national meetings of science educators. A plan is in place to proactively accept teachers from schools with a significant population of underserved minority students. And finally, the broad dissemination of the project’s instructional materials will be achieved through our established partnerships with other science outreach organizations whose programs focus on URM students in urban Milwaukee, Chicago and rural Nebraska and South Dakota.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11113", "attributes": { "award_id": "7R21NS125484-02", "title": "Chronic Stress Induces Neuroimmune Modulated Primary Muscle Afferent Sensitization", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 12056, "first_name": "DURGA PRASANNA", "last_name": "Mohapatra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-12-15", "end_date": "2024-08-31", "award_amount": 390500, "principal_investigator": { "id": 26682, "first_name": "Luis Fernando", "last_name": "Queme Cobar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1655, "ror": "https://ror.org/02n2ava60", "name": "University of New England", "address": "", "city": "", "state": "ME", "zip": "", "country": "United States", "approved": true }, "abstract": "Many patients with chronic pain concomitantly present with increased levels of stress and anxiety. Multiple reports point to the immune system as a potential link between stress and chronic pain development. Stress activates immune cells and increases pro-inflammatory cytokines, which can modulate peripheral sensitization and regulate prolonged hypersensitivity through gene expression changes in primary sensory neurons. Our objective is to characterize the stress-induced neuroimmune interactions that modulate primary afferent sensitization and lead to the development of prolonged ischemic muscle pain. Macrophages are one of the key immune cells involved in these neuroimmune interactions that regulate peripheral sensitization, but the role of macrophages in development of stress-induced muscle hyperalgesia and hypersensitivity remains unknown. This proposal explores effects of stress in the peripheral nervous system in a new way -- selectively inhibiting or enhancing macrophage -mediated inflammatory responses to stress and testing its role in the development muscle pain-related behaviors. It will use and validate a never before used, loss of environmental enrichment (LOE) mouse model of stress that does not employ the potential confounder of noxious physical stimulation. Interestingly, this paradigm replicates a stressor frequently experienced during the COVID-19 pandemic - LOE due to social distancing. Our preliminary data showed gene expression changes in the dorsal root ganglia (DRG) and innervated tissue modulated response properties of muscle afferents after ischemic injury (I/R) modulated, in part, by proinflammatory cytokine signaling. LOE induced stress resulted in increased pain- related behaviors after injury and increased macrophage infiltration in skeletal muscle. We hypothesize that LOE-induced stress induces peripheral sensitization via immune cell-dependent mechanisms to modulate the development of ischemic myalgia. We will use transgenic and chemogenetic approaches in mice with LOE-related stress plus ischemic/reperfusion (I/R) injury, our ex vivo hind paw muscle afferent recording strategies and pain-related behavioral assays. Aim 1 will identify if stress modulates peripheral sensitization after injury (I/R) through macrophage infiltration by depleting macrophages in macrophage fas- induced apoptosis (MaFIA) mice exposed to LOE with or without I/R. Electrophysiological experiments will be paired with detailed profiling of the transcriptome of the DRG under stress. Aim 2 will evaluate the role of stress- induced immune alterations in peripheral sensitization after I/R by using transgenic mice expressing designer receptors exclusively activated by designer drugs (DREADDs) driven by Cre-recombinase expression from the Lysozyme-2 promotor (LysM, only expressed myelomonocytic cells, such as macrophages).Characterization of the mechanisms of stress-induced neuroimmune interactions that modulate primary afferent sensitization will elucidate the role of macrophages in development of stress-induced muscle hyperalgesia and hypersensitivity.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8183", "attributes": { "award_id": "7R21LM013683-02", "title": "Identifying existing, FDA-approved drugs with clinically protective effects against coronavirus disease 2019 using a big data approach", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Library of Medicine (NLM)" ], "program_reference_codes": [], "program_officials": [ { "id": 23263, "first_name": "JANE", "last_name": "YE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-04-20", "end_date": "2023-03-31", "award_amount": 245839, "principal_investigator": { "id": 24024, "first_name": "Josh", "last_name": "Lambert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1446, "ror": "https://ror.org/01e3m7079", "name": "University of Cincinnati", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24025, "first_name": "Harpal Singh", "last_name": "Sandhu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1446, "ror": "https://ror.org/01e3m7079", "name": "University of Cincinnati", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "Coronavirus Disease 2019 (COVID-19) is a national and global public health emergency. Because the causative virus is novel, the present options for treatment are extremely limited, and an effective vaccine could be 1-2 years away. Thus, there is an urgent need for efficacious therapeutics against the disease. While development of new drugs is under way, that process is slow and resource-intensive. In the short-to-medium term, a superior strategy is to repurpose already existing drugs to treat the disease. Over 100 drugs already approved by the Food and Drug Administration (FDA) have shown in vitro, in silico, or theoretical effect against SARS-CoV-2, the virus that causes COVID-19, or the hyperinflammatory immune response it provokes. What is unclear is how many of these have a significant, protective effect on actual patients, as only a tiny fraction of these drugs is in clinical trials. Most of these agents are chronic medications, and thus there are millions of Americans who are already using them. The first aim of this study is to assess the degree of protection any of these drugs confers against the serious complications of COVID-19 while adjusting for known risk factors and confounders. The second aim is to search for additional interactions between drugs or combinations of drugs and specific demographic and/or clinical subgroups that could be protective or harmful. The Change Healthcare Database, a part of the COVID-19 Research Database, contains up-to-date health insurance claims data for about one-third of all Americans. Using this database, this study will evaluate the impact of these drugs on the risk of four important outcomes in patients who are COVID-19-positive: need for hospitalization, use of mechanical ventilation, shock, and death. Results will be risk-adjusted for the risk factors already well established to predict poor outcomes in COVID-19. This study will further mine the data for second- and third- order interactions between drugs or combinations of drugs and different subpopulations of patients using a novel machine learning method called the Feasible Solution Algorithm (FSA). The FSA enables the researcher to uncover higher-order statistical interactions in regression models, which leads to the identification of subgroups and complexities that are not always apparent with traditional regression models. If the results show candidate drugs with highly protective effects, these can be prioritized for prospective clinical studies. Drugs that show harmful effects can be considered for discontinuation in infected or high-risk patients.", "keywords": [ "2019-nCoV", "Algorithms", "American", "Big Data", "COVID-19", "COVID-19 diagnosis", "COVID-19 treatment", "Cessation of life", "Chronic", "Clinical", "Clinical Research", "Clinical Trials", "Data", "Databases", "Development", "Disease", "Drug Combinations", "Health Insurance", "Healthcare", "Hospitalization", "Immune response", "In Vitro", "Mechanical ventilation", "Modeling", "Outcome", "Patients", "Pharmaceutical Preparations", "Process", "Research", "Research Personnel", "Resources", "Risk", "Risk Factors", "SARS-CoV-2 positive", "Shock", "Statistical Algorithm", "Subgroup", "Therapeutic", "United States Food and Drug Administration", "Vaccines", "Virus", "coronavirus disease", "drug candidate", "high risk", "in silico", "insurance claims", "machine learning method", "novel", "novel therapeutics", "patient subsets", "prospective", "protective effect", "public health emergency" ], "approved": true } }, { "type": "Grant", "id": "11456", "attributes": { "award_id": "7R21HD105907-03", "title": "The impact of COVID-19 on child maltreatment-related medical encounters and system responses using linked administrative data", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 27515, "first_name": "LEAH KAYE", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-03-01", "end_date": "2023-06-30", "award_amount": 252121, "principal_investigator": { "id": 24277, "first_name": "Rebecca", "last_name": "Rebbe", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: With schools and daycare facilities closed and unemployment rates soaring due to the COVID- 19 pandemic, experts worry not only that the incidence of child maltreatment has increased but that that new or recurrent cases of maltreatment have gone undetected because two-thirds of reports to child protective services (CPS) are made by professionals. Linked administrative data (i.e., records collected for the provision of services, including health and child protection) can overcome the challenges of relying solely on CPS reports by joining the CPS database with medical records. Medical records have been identified as a useful data source for measuring child maltreatment. The objective of this application is to determine if and how the COVID-19 pandemic has impacted the incidence of child maltreatment-related medical encounters and the system responses to diagnosed cases of maltreatment. The rationale is maltreatment has significant identified impacts on children and if maltreatment has increased during this time, it will be important to allocate resources to address this detrimental form of trauma. The proposed study will take advantage of a natural experiment to focus on two specific aims: 1) Compare the incidence rates of child maltreatment-related medical encounters, before and during COVID-19; and 2) Determine the social and legal interventions/system responses to diagnosed medical encounters of child maltreatment before and during the pandemic. For the first aim, an interrupted time series will be used to identify the frequency of diagnosed maltreatment in primary care, emergency department, and hospitalization medical encounters. For the second aim, interrupted time series and logistic regression will be used to determine the percentage and likelihood of diagnosed maltreatment-related medical encounters being reported to CPS. The proposed research is innovative because it uses data from multiple sources and includes several types of medical encounters. The proposed research is significant because maltreatment is highly consequential but difficult to measure. Results will identify with robust empirical evidence if the pandemic COVID-19 has increased the incidence and severity of child maltreatment-related medical encounters and changed the social and legal interventions in response to such medical encounters. Ultimately, such knowledge has the potential to identify how community-level events impact child maltreatment, informing public policy, resource allocation, professional training, and future research.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 3, "pages": 1392, "count": 13920 } } }