Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=3&sort=-approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=2&sort=-approved" }, "data": [ { "type": "Grant", "id": "1536", "attributes": { "award_id": "2029774", "title": "RAPID: Comparative genomics of SARS-CoV-2 susceptibility and immune defense in mammals", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9179" ], "program_officials": [ { "id": 4007, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-05-15", "end_date": "2021-04-30", "award_amount": 199767, "principal_investigator": { "id": 4009, "first_name": "Elinor K", "last_name": "Karlsson", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 613, "ror": "https://ror.org/0464eyp60", "name": "University of Massachusetts Medical School", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4008, "first_name": "Diane P", "last_name": "Genereux", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 613, "ror": "https://ror.org/0464eyp60", "name": "University of Massachusetts Medical School", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The goal of this project is to compare genomes of hundreds of mammal species, finding differences in DNA that distinguish species resistant to SARS-CoV-2 from those that are very susceptible. This information is needed to understand how the current SARS-CoV-2 virus spread to humans and to identify potential host animals (e.g., pet, livestock, and pest species) that may be susceptible to SARS-CoV-2 in the USA. SARS-CoV-2, the cause of the COVID-19 pandemic, can infect diverse species of animals. There is a variation in susceptibility to and severity of disease between species. This variation suggests that some species have genetic differences that dictate susceptibility to COVID-19. This work will identify how coronaviruses adapt to new host species, information that will help predict and control future coronavirus outbreaks. Funding will support training a graduate student in research, thereby training the next generation of the bioeconomy workforce. This project will investigate how the host genome shapes host-pathogen interactions, and how coronaviruses like SARS-CoV-2 evolve to exploit new hosts. The researchers will compare existing genomic data for hundreds of mammals using three complementary approaches: (1) Measure structural and sequence homology in two host proteins, ACE2 and TMPRSS2, necessary for infection in humans; (2) Analyze existing RNA-seq datasets to (a) identify species with co-expression of ACE2 and TMPRSS2, and potentially other proteases implicated in infection, in the same tissue, and (b) search for incidental coronaviral sequence data from diverse mammalian species; (3) Test for variants in evolutionarily conserved elements that are correlated with species susceptibility, using forward genomics. With these analyses, the researchers will identify species with potential as reservoirs for SARS-CoV-2 viral spillback into humans, and those that are promising systems for investigating SARS-CoV-2 evolution, host defenses, and host-pathogen interactions. This RAPID award is made by the Physiological and Structural Systems Cluster in the BIO Division of Integrative Organismal Systems, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8448", "attributes": { "award_id": "1U01DD001293-01", "title": "Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-07-01", "end_date": "2026-06-30", "award_amount": 581307, "principal_investigator": { "id": 24212, "first_name": "Julie L", "last_name": "Daniels", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "- SEED Follow-up Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The NC SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in North Carolina and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4352", "attributes": { "award_id": "1458514", "title": "Geoscience Scholarships to Improve Recruitment and Retention of Academically Talented Students", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "S-STEM-Schlr Sci Tech Eng&Math" ], "program_reference_codes": [], "program_officials": [ { "id": 14805, "first_name": "Keith", "last_name": "Sverdrup", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2015-04-01", "end_date": "2021-03-31", "award_amount": 639136, "principal_investigator": { "id": 14809, "first_name": "Amy", "last_name": "Sheldon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1269, "ror": "", "name": "SUNY College at Geneseo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 14806, "first_name": "Dori J", "last_name": "Farthing", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 14807, "first_name": "Scott D", "last_name": "Giorgis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 14808, "first_name": "Nicholas H", "last_name": "Warner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1269, "ror": "", "name": "SUNY College at Geneseo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This project at SUNY Geneseo will address the national need for more and better trained geoscientists by increasing recruitment, retention to graduation, and preparation for and placement in careers or geosciences graduate programs and by combining scholarships and academic and career services. Through many student support and enrichment activities, this project will enhance interactions between SUNY Geneseo and academic institutions including SUNY Buffalo and SUNY Binghamton where many new geosciences graduates from the college pursue M.S. or Ph.D. degrees. In addition, connections to regional geosciences industries, including the American Rock Salt Company and Stell Environmental Enterprises, as well as government and academic research programs such as NASA, DOE, and a variety of National Laboratory and Research Experience for Undergraduates programs, will be strengthened through the development of opportunities for student research and internships. Together, these improvements will increase the number and quality of research opportunities for undergraduate geosciences students, increase opportunities for students to participate and present at professional and scholarly conferences, and address the national need to increase the number of geosciences students to fill jobs in oil and gas, environmental service, and mining industries. \n\nThe project will target students majoring in geology, geochemistry, and geophysics at SUNY Geneseo and is designed to meet three objectives: (1) increase recruitment and enrollment of academically talented students with financial need by at least 20%, (2) enhance retention and graduation within four years by at least 10%, and (3) increase placement in a geosciences or related science, technology, engineering, or mathematics (STEM) career or graduate program by 13%. The project leadership will work with the Office of Admissions and twenty alumni who are geoscience teachers at high schools in western New York to recruit academically talented scholars with financial need to the program. Cohorts of scholars will be brought together by (a) taking the same classes, (b) engaging in supplemental instruction programs, (c) participating in field trips, (d) interacting with graduate students and alumni, and (v) engaging in research and/or internships. The program goals will be accomplished through two primary components: (i) enhanced student support programs, and (ii) experiential learning opportunities. Career placement-related program components will be supplemented with support from the Office of Career Development. The scholarship program will allow SUNY Geneseo to implement and assess support services for geosciences students, including Supplemental Instruction (SI), Workshops with Graduate Students, a Geology Alumni-Student Program, field trips, research experiences, and internships. SI is a proven method to increase retention and graduation rates in many STEM disciplines; however, the effectiveness of SI has not been tested in the geosciences. This program will fill that void and provide insight into best practices and effective measures for promoting retention, graduation, and placement in the geosciences.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4096", "attributes": { "award_id": "1607069", "title": "2016 Cellular & Molecular Fungal Biology GRC, Plymouth, New Hampshire, June 19-24, 2016", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [ { "id": 13758, "first_name": "Michael", "last_name": "Mishkind", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-07-01", "end_date": "2017-06-30", "award_amount": 15000, "principal_investigator": { "id": 13759, "first_name": "Amy", "last_name": "Gladfelter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will facilitate the attendance and participation of early career scientists in the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 19-24, 2016. The goal of the conference is to disseminate information about fungal biology among an interdisciplinary group of researchers, and to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are essential parts of the terrestrial nutrient cycle, play a central role in the development of biofuels, and produce many critically important chemicals. These diverse applications of fungi require the interdisciplinary acquisition and application of fundamental fungal biology. This project will support the convergence and exchange of new findings amongst an interdisciplinary group of scientists dedicated to the study of fungi. \n\nThe intellectual merit of the project is rooted in the meeting's highly interdisciplinary and interactive format. The meeting will feature topics that integrate multiple time and space scales for different questions in fungal biology to promote interactions amongst researchers with diverse perspectives within the community. There is a specific emphasis on integrating mathematical modeling and biophysics as a new addition to this meeting and an entire session is dedicated to the interface of fungal biology with the physical sciences. The meeting enables cross-fertilization of ideas, from cell biology to evolution, that occurs in and outside of the sessions and especially between junior and senior scientists. Young investigators emphasize from previous meetings how interactive the conference is and how responsive it is to the presentation of their work.\n\nThis conference has broad impacts on training and is dedicated to extending the research community by emphasizing women and members of underrepresented groups in inviting speakers. The current invited speakers are approximately 50% women, including several Latinas. The small size of the meeting and the emphasis on discussion (40% of meeting time is dedicated to discussions) encourages active participation. Poster sessions are featured without competing events to focus attention on the most junior scientists, who often have the newest data. The GRC on Cell and Molecular Fungal Biology also is dedicated to research that applies basic knowledge to socially important questions involving filamentous fungi, particularly mutualisms with plants (mycorrhizae), parasitism with plants (plant pathology) and animals (animal pathology), and industrial mycology (enzyme production). The interactions among researchers focused on both basic and socially important research speeds research aimed at solving societal problems caused by or that can be improved by fungi.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8192", "attributes": { "award_id": "5R01AG071649-02", "title": "The economic and social impact of COVID-19 mitigation policies: A cross-country analysis of macro events", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8410, "first_name": "MINKI", "last_name": "CHATTERJI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-04-15", "end_date": "2026-01-31", "award_amount": 839609, "principal_investigator": { "id": 24033, "first_name": "Dean R", "last_name": "Lillard", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "The project, \"The economic and social impact of COVID-19 mitigation policies: A cross- country analysis of macro events,\" will explore the economic and social effects the mitigation policies and information environment that COVID-19 spawned. We will link those policies to data from ongoing household-based panel studies from 10 countries and rich administrative data from an eleventh. We will exploit the substantial intra and inter-country temporal and geographic variation in non-pharmacological intervention policies induced by the COVID-19 disease. That variation, coupled with pre-COVID baseline levels or long-running trends in the outcomes we will study, will identify the effects of the mitigation policies.", "keywords": [ "2019-nCoV", "Behavior", "COVID-19", "Case Fatality Rates", "Cessation of life", "Characteristics", "China", "Code", "Communities", "Coronavirus", "Country", "Coupled", "Data", "Demography", "Diagnosis", "Disease", "Economics", "Elderly", "Employment", "Environment", "Event", "Family member", "Federal Government", "Government", "Herd Immunity", "Heterogeneity", "Hospitalization", "Household", "Human", "Income", "Individual", "Industry", "Intervention", "Italy", "Life", "Link", "Local Government", "Medical", "Modeling", "Nature", "Occupations", "Outcome", "Pattern", "Personal Satisfaction", "Persons", "Policies", "Population", "Protocols documentation", "Records", "Research", "Research Personnel", "Resource Sharing", "Respondent", "Running", "SARS coronavirus", "SARS-CoV-2 infection", "Sampling", "Scientist", "Severe Acute Respiratory Syndrome", "Shock", "Social Impacts", "Sociology", "Surveys", "System", "Time", "Uncertainty", "Update", "Variant", "base", "coronavirus disease", "discount", "economic impact", "epidemiological model", "experience", "geographic difference", "member", "mortality", "outreach", "pandemic disease", "risk perception", "satisfaction", "social", "symposium", "transmission process", "trend" ], "approved": true } }, { "type": "Grant", "id": "7936", "attributes": { "award_id": "1R43HL164325-01", "title": "IVOS Medical: Intubation, optimized.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 6344, "first_name": "Lora A.", "last_name": "Reineck", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-04-01", "end_date": "2022-09-30", "award_amount": 247334, "principal_investigator": { "id": 23805, "first_name": "Gabriel", "last_name": "Punsalan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1644, "ror": "", "name": "IVOS MEDICAL LLC", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23806, "first_name": "WAYLAN", "last_name": "WONG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1644, "ror": "", "name": "IVOS MEDICAL LLC", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Endotracheal intubation (ETI) is a frequently used life-saving procedure performed daily. In the US alone, 15 million operating room intubations and 650,000 out-of-operating room intubations are performed annually. At the initial outbreak of the SARS-Cov-2 pandemic of 2020, more than 70% of critically ill patients were intubated and with new mutations, the increase in emergent intubation is only going to continue. Despite its frequency, ETI is a high-risk procedure, with significant rates of respiratory complications, hemodynamic instability, and cardiac arrest. Developed in the early 2000s, the video laryngoscope (VL) was created to assist with difficult intubations vs the traditional practice by direct laryngoscopy (DL). This new method of intubation works by means of a video camera on the distal end of the laryngoscope blade which is inserted into the mouth and provides an indirect view of the vocal cords on a separate monitor. This widely-used tool for visualizing the airway has garnered more acceptance as a first line tool for intubation in an emergent setting.The current problem with intubation by means of video laryngoscopy is that they become virtually useless when the camera view is obscured by bodily fluids, e.g., gastric contents and blood. IVOS Medical, LLC is a new medical device startup developing an economical, disposable and novel video laryngoscope sleeve for maintaining clear vision during breathing tube placement. The goal for our video laryngoscope apparatus is to elevate the current safety profile of intubation by decreasing aspiration risk and the time an individual goes without oxygen, while increasing intubation accuracy in patients who present with high risk of mortality. We believe our device will benefit first responders and healthcare providers throughout our nations’ medical centers in particular emergency departments, surgical suites and intensive care units. Preliminary testing in our Laerdal airway manikin with our prototype IVOS Medical BOSS G4, has shown significant improvement of visual acuity after clearing away simulated bodily fluids from the camera lens. Aims of this proposal are 1: Further development of 3D printed IVOS Medical BOSS Glide 4 (G4) video laryngoscope sleeve and compare speed and efficiency of successful intubation under aspiration conditions against the popular Verathon Glidescope AVL Blade 4, among 60 medical operators. 2: Perform Finite Element Analysis (FEA) of the BOSS G4 sleeve. 3: Develop and create 25 urethane injection molded samples of IVOS Medical Boss G4 laryngoscope sleeves. Phase II will focus on design based on end user feedback, additional testing including on human cadavers. Analysis of the suction capabilities to capture and remove potential airborne viral particles from the oropharyngeal space can be investigated at this time. Furthermore, additional physical and materials testing will be performed to reach the commercial-ready point at the end of Phase II. We believe that we can help save many lives affected everyday as well as increase the safety net for other medical professionals performing this life saving procedure.", "keywords": [ "3D Print", "Accident and Emergency department", "Affect", "Anatomy", "Aspirate substance", "Aspiration Pneumonia", "Blood", "Brain Injuries", "Breathing", "COVID-19 outbreak", "COVID-19 pandemic", "Cadaver", "Cessation of life", "Critical Illness", "Data", "Development", "Devices", "Distal", "Effectiveness", "Event", "Excision", "Feedback", "Finite Element Analysis", "Foundations", "Frequencies", "Gases", "Goals", "Health Personnel", "Heart Arrest", "Human", "Individual", "Injections", "Intensive Care Units", "Intratracheal Intubation", "Intubation", "Laryngoscopes", "Laryngoscopy", "Lead", "Life", "Liquid substance", "Manikins", "Manufacturer Name", "Materials Testing", "Medical", "Medical Device", "Medical center", "Methods", "Modeling", "Molds", "Monitor", "Mutation", "Operating Rooms", "Operative Surgical Procedures", "Oral cavity", "Oropharyngeal", "Oxygen", "Patients", "Phase", "Procedures", "Research", "Risk", "Safety", "Sampling", "Savings", "Specialist", "Speed", "Stomach", "Suction", "Testing", "Time", "Tube", "Urethane", "Viral", "Vision", "Visual Acuity", "Visualization", "Work", "base", "design", "first responder", "hemodynamics", "high risk", "lens", "mortality risk", "novel", "particle", "prevent", "prototype", "respiratory", "safety net", "symposium", "tool", "virtual", "vocal cord" ], "approved": true } }, { "type": "Grant", "id": "7680", "attributes": { "award_id": "5R01AI132178-04", "title": "Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoV", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6011, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-08-09", "end_date": "2022-07-31", "award_amount": 1166670, "principal_investigator": { "id": 6339, "first_name": "Ralph S", "last_name": "Baric", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 21236, "first_name": "Timothy Patrick", "last_name": "Sheahan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "Zoonotic viruses, like filoviruses and coronaviruses (CoV), represent a continuous and growing threat to global public health because they unpredictably emerge causing devastating outbreaks of pandemic disease. In the 21st century, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged from zoonotic pools of viruses, causing severe disease in humans. MERS-CoV is endemic in camels in the Middle East with continuous new infections in humans. Although SARS-CoV is not currently a threat, several “prepandemic” SARS-like CoVs have been isolated from bats that replicate efficiently in human cells and are resistant to existing therapies. With the unpredictable overlap of human and wild animal ecologies, the potential for novel CoV emergence into humans is highly probable. Currently, there are no approved antiviral therapies for any human CoV infection. Broad-spectrum CoV therapies that control known human and zoonotic CoV infections would address an immediate unmet medical need and could counter future pandemic episodes. In partnership with Gilead Sciences, we have demonstrated that the nucleoside prodrug, GS-5734, is highly efficacious in inhibiting multiple human and zoonotic CoV in vitro and SARS-CoV in vivo. The primary goal of our program is to accelerate the preclinical development of GS-5734 and promote IND licensure for the MERS-CoV indication. To thoroughly evaluate the breadth of antiviral activity and predict efficacy against future emerging CoV, we will also assess efficacy against a panel of CoV representative of family-wide genetic diversity, including prepandemic zoonotic strains poised for emergence. Focusing on the highly pathogenic MERS-CoV, our unique partnership integrates: i) metagenomics and recombinant virus synthetic genome recovery, ii) primary human lung cell models, iii) cutting edge virology and biochemistry, iv) robust murine and primate models of human disease and v) state of the art metabolic and pharmacokinetic analysis. In Aim 1, we refine the pharmacokinetics, pharmacodynamics and breadth of GS-5734 through efficacy and metabolism studies in various primary human cells with a diverse array of human and zoonotic CoV and through the evaluation of in vivo efficacy in murine and non-human primate models of MERS- and SARS-CoV. In Aim 2, we select for resistance against SARS-CoV and MERS- CoV, and determine the effect of resistance on virus replication, fitness and susceptibility to treatment. In Aim 3, we determine if the mechanism of action of GS-5734 is a result of direct effects on viral RNA replication and/or alteration of antiviral immunity via deep sequencing and single molecule RNA fluorescence in situ hybridization of vehicle or drug treated infected cells and mice. We articulate a development strategy for broad- spectrum therapeutics that could be extended to a multitude of emerging viral pathogens threatening global public health.", "keywords": [ "Address", "Animal Model", "Animals", "Antiviral Agents", "Antiviral Therapy", "Attenuated", "Biochemistry", "Birds", "Camels", "Cell Culture Techniques", "Cell model", "Cells", "Chiroptera", "Clinical Trials", "Coronavirus", "Coronavirus Infections", "Data", "Development", "Disease", "Disease Outbreaks", "Drug Kinetics", "Endothelium", "Engineering", "Epithelial Cells", "Exons", "Family", "Filovirus", "Fluorescent in Situ Hybridization", "Fostering", "Future", "Generations", "Genetic", "Genetic Variation", "Genome", "Goals", "Hepatitis", "Human", "Immune", "In Vitro", "Infection", "Innate Immune Response", "Licensure", "Lung", "Mammals", "Measurement", "Mediating", "Medical", "Metabolic", "Metabolism", "Metagenomics", "Middle East", "Middle East Respiratory Syndrome", "Middle East Respiratory Syndrome Coronavirus", "Modeling", "Mus", "Mutate", "Mutation", "Nucleosides", "Parents", "Pathogenesis", "Pathogenicity", "Pathway interactions", "Pharmaceutical Preparations", "Pharmacodynamics", "Pharmacologic Substance", "Predisposition", "Primates", "Prodrugs", "Proteins", "Public Health", "RNA", "RNA Viruses", "RNA chemical synthesis", "RNA replication", "RNA-Directed RNA Polymerase", "Recovery", "Resistance", "Resistance profile", "Resolution", "SARS coronavirus", "Science", "Serum", "Severe Acute Respiratory Syndrome", "T-Lymphocyte", "Testing", "Therapeutic", "Toxic effect", "Transgenic Mice", "Treatment Efficacy", "Viral Genome", "Viral Pathogenesis", "Virus", "Virus Replication", "Wild Animals", "Zoonoses", "aged", "airway epithelium", "alveolar type II cell", "animal ecology", "anti-viral efficacy", "antiviral immunity", "biological systems", "clinical application", "coronavirus receptor", "cross-species transmission", "deep sequencing", "design", "drug metabolism", "efficacy study", "esterase", "fitness", "human coronavirus", "human disease", "human model", "improved", "in vivo", "in vivo evaluation", "in vivo imaging", "metabolic abnormality assessment", "mouse model", "nonhuman primate", "novel coronavirus", "pandemic disease", "pathogenic virus", "pharmacokinetics and pharmacodynamics", "pre-clinical", "preclinical development", "programs", "recombinant virus", "remdesivir", "replicase", "resistance mutation", "single molecule", "transcriptome sequencing", "tripolyphosphate", "uptake", "viral RNA", "viral fitness", "virology" ], "approved": true } }, { "type": "Grant", "id": "7424", "attributes": { "award_id": "3P30CA033572-37S2", "title": "A Phase 2 Trial of Leflunomide for the Treatment of COVID‐19 in Patients with Solid Tumors and Hematologic Malignancies", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 20549, "first_name": "Sonya", "last_name": "Roberson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2022-11-30", "award_amount": 440000, "principal_investigator": { "id": 23218, "first_name": "STEVEN Terry", "last_name": "ROSEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1493, "ror": "", "name": "BECKMAN RESEARCH INSTITUTE/CITY OF HOPE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1493, "ror": "", "name": "BECKMAN RESEARCH INSTITUTE/CITY OF HOPE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Novel interventions are urgently needed to address the COVID-19 pandemic, especially for highrisk populations. Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor, impacting pyrimidine synthesis for DNA and RNA production, and has been in use for over 20 years for treatment of autoimmune diseases such as rheumatoid arthritis and lupus with an excellent safety profile [1, 2]. It has known anti-viral activity and has been applied against cytomegalovirus (CMV) and polyoma BK virus infections in immunocompromised hosts [3, 4]. Leflunomide is orally available and exhibits hepatic clearance and a long elimination half-life. In vitro and in vivo experiments conducted in Wuhan, China demonstrated DHODH inhibitors have activity against COVID-19, including teriflunomide, the active metabolite of leflunomide [5]. Moreover, our preliminary data at City of Hope also suggest that leflunomide significantly arrests viral RNA replication in cancer cells infected with a naturally-occurring RNA virus (reovirus) and impairs ex vivo IL-6 expression in virally infected peripheral blood mononuclear cells (PBMCs).", "keywords": [ "Achievement", "Address", "Antiviral Agents", "Autoimmune Diseases", "BK Virus", "COVID-19", "COVID-19 pandemic", "Cancer Burden", "Cancer Patient", "Caring", "Characteristics", "China", "Cities", "City of Hope Comprehensive Cancer Center", "Clinical", "Clinical Investigator", "Collaborations", "Communities", "Cytomegalovirus", "DHODH gene", "DNA biosynthesis", "Data", "Development", "Diagnosis", "Dihydroorotate dehydrogenase", "Education", "Exhibits", "Fostering", "Goals", "Half-Life", "Hematologic Neoplasms", "Hepatic", "Immunocompromised Host", "Impairment", "In Vitro", "Individual", "Infrastructure", "Interleukin-6", "Intervention", "Investigation", "Leflunomide", "Link", "Lupus", "Malignant Neoplasms", "Methods", "Mission", "Oral", "Patient Care", "Patients", "Peripheral Blood Mononuclear Cell", "Polyomavirus", "Population", "Prevention", "Prevention strategy", "Production", "Pyrimidine", "RNA", "RNA Viruses", "RNA replication", "Reovirus", "Research", "Resource Sharing", "Rheumatoid Arthritis", "Safety", "Solid Neoplasm", "Speed", "Strategic Planning", "Viral", "Viral Physiology", "Virus Diseases", "cancer cell", "cancer rehabilitation", "experimental study", "first-in-human", "high risk", "in vivo", "inhibitor/antagonist", "innovation", "novel", "phase II trial", "population based", "survivorship", "viral RNA" ], "approved": true } }, { "type": "Grant", "id": "3328", "attributes": { "award_id": "1811163", "title": "Advancing the Design of Visualizations for Informal Science Engagement", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "AISL" ], "program_reference_codes": [], "program_officials": [ { "id": 10551, "first_name": "Chia", "last_name": "Shen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-10-01", "end_date": "2019-12-31", "award_amount": 249677, "principal_investigator": { "id": 10553, "first_name": "Jennifer", "last_name": "Frazier", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1082, "ror": "https://ror.org/0037yf233", "name": "Exploratorium", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 10552, "first_name": "Joyce", "last_name": "Ma", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1082, "ror": "https://ror.org/0037yf233", "name": "Exploratorium", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "As part of its overall strategy to enhance learning in informal environments, the Advancing Informal STEM Learning (AISL) program seeks to advance new approaches to, and evidence-based understanding of, the design and development of STEM learning in informal environments. This includes providing multiple pathways for broadening access to and engagement in STEM learning experiences, advancing innovative research on and assessment of STEM learning in informal environments, and developing understandings of deeper learning by participants. This project is a two-day conference, along with pre- and post-conference activities, with the goal of furthering the informal science learning field's review of the research and development that has been conducted on data visualizations that have been used to help the public better understand and become more engaged in science. The project will address an urgent need in informal science education, providing a critical first step towards a synthesis of research and technology development in visualization and, thus, to inform and accelerate work in the field in this significant and rapidly changing domain.\n\nThe project will start with a Delphi study by the project evaluator prior to the conference to provide an Emerging Field Assessment on data visualization work to date. Then, a two-day conference at the Exploratorium in San Francisco and related activities will bring together AISL-funded PIs, computer scientists, cognitive scientists, designers, and technology developers to (a) synthesize work to date, (b) bring in relevant research from fields outside of informal learning, and (c) identify remaining knowledge gaps for further research and development. The project team will also develop a website with videos of all presentations, conference documentation, resources, and links to social media communities; and a post-conference publication mapping the state of the field, key findings, and promising technologies. \n\nThe initiative also has a goal to broaden participation, as the attendees will include a diverse cadre of professionals in the field who contribute to data visualization work.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4608", "attributes": { "award_id": "1439327", "title": "CISE/CCF: 2014 Summer School on Formal Techniques", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)", "Software & Hardware Foundation" ], "program_reference_codes": [], "program_officials": [ { "id": 15901, "first_name": "Nina", "last_name": "Amla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2014-04-01", "end_date": "2015-03-31", "award_amount": 85000, "principal_investigator": { "id": 15902, "first_name": "Natarajan", "last_name": "Shankar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 325, "ror": "https://ror.org/05s570m15", "name": "SRI International", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 325, "ror": "https://ror.org/05s570m15", "name": "SRI International", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Formal verification techniques such as model checking, satisfiability solving, theorem proving, and static analysis have matured rapidly in recent years. These techniques have a number of important applications ranging from the modeling and analysis of biological and cyber-physical systems to the verification of the safety and security of complex software systems. The Summer School on Formal Techniques trains students in the principles and practice of formal verification, with a strong emphasis on the hands-on use and development of this technology. It primarily targets graduate students and young researchers who are interested in using verification technology in their own research in fields such as computing, engineering, biology, and mathematics. Students at the school are given the opportunity to experiment with the tools and techniques presented in the lectures.\n\nThe 2014 edition of the Summer School is the fourth in the series takes place during May 19-23, 2014. Topics covered in this school include logic, formalization, interactive theorem proving, SAT and SMT solving, model checking, program semantics, modeling and verification of security protocols, and software reliability. The students cooperate in solving challenging problems while learning to use cutting-edge tools and techniques.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 3, "pages": 1392, "count": 13920 } } }