Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=3&sort=-abstract
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-abstract", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-abstract", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=4&sort=-abstract", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=2&sort=-abstract" }, "data": [ { "type": "Grant", "id": "8753", "attributes": { "award_id": "1P50MD017319-01", "title": "FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Black/African American Smokers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-24", "end_date": "2026-06-30", "award_amount": 645796, "principal_investigator": { "id": 24546, "first_name": "Pebbles", "last_name": "Fagan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "– PROJECT 2 Blacks/African Americans have the highest cigarette smoking-attributable cancer mortality rates in the United States. Cigarette smoking is nearly double the national average (23%-26%) in Arkansas rural counties where more than 48% of the population is Black/African American. Social structural stressors such as persistent poverty, low educational attainment, high rates of unemployment, the COVID-19 pandemic, poor transportation, poor access to health care, and historical oppression pose tremendous barriers to successful quitting. Quitting smoking can substantially reduce cancer morbidity and mortality among African Americans, but successful quitting as well as the reach of evidence-based interventions to rural African Americans is alarmingly low. Few studies have empirically tested the efficacy of social structural interventions (home-based food delivery) that address the dynamic interplay of cancer risk behaviors, like smoking, and social factors that perpetuate disparities like food insecurity. The long-term goal of this study is to fill a critical gap in knowledge on the role of social structural interventions in the elimination of cancer health disparities in low resource rural Arkansas counties with high proportions of Blacks/African Americans and high smoking prevalence. Our aims are to 1) test the efficacy of a social change intervention (home-based food delivery) on smoking abstinence using a 3-armed randomized controlled design, 2) examine changes in measures of cigarette abuse liability, and 3) examine the extent to which home-based food delivery improves recruitment and retention of Black/African American smokers in the treatment conditions. Our academic-community partnership – the University of Arkansas for Medical Sciences, Coalition for a Tobacco Free Arkansas, and the Arkansas Foodbank – has a strong collaborative foundation and experience in working together to reduce tobacco use in rural Arkansas Delta counties with high proportions of Blacks/African Americans. Multilevel interventions are needed to address persistent social conditions that potentially increase the abuse liability of smoking and impede successful quitting. Smokers who are more food insecure are less likely to quit smoking. Our multidisciplinary team will use the Socioecological Model to test our central hypothesis: smokers who receive evidence-based real-time video-based motivational counseling and a social change intervention (home-based food delivery) will have greater cotinine-verified 7-day point prevalence abstinence than those who receive motivational counseling alone or social change alone. Social structural interventions that meet the immediate social needs of Black/African American smokers hold tremendous promise for improving Black/African American recruitment and retention into helpful cancer prevention community trials, increasing successful quitting, and reducing social disparities that perpetuate tobacco-caused cancer disparities.", "keywords": [ "Abstinence", "Acetaldehyde", "Acrolein", "Address", "African American", "Arkansas", "Benzaldehyde", "Biological Markers", "Body mass index", "COVID-19 pandemic", "Cancer Etiology", "Carbon Monoxide", "Cessation of life", "Chronic Disease", "Cigarette", "Community Trial", "Consumption", "Cotinine", "Counseling", "County", "Discrimination", "Dose", "Evidence based intervention", "Face", "Failure", "Food", "Food Access", "Formaldehyde", "Foundations", "Goals", "Health", "Health Food", "Healthcare", "Home", "Income", "Intervention", "Knowledge", "Malignant Neoplasms", "Measures", "Medical", "Modeling", "Morbidity - disease rate", "Motivation", "Nicotine Dependence", "Population", "Poverty", "Prevalence", "Preventable cancer cause", "Research", "Resources", "Risk Behaviors", "Role", "Rural", "Science", "Smoker", "Smoking", "Social Change", "Social Conditions", "Social Justice", "Structural Racism", "Structure", "System", "Testing", "Time", "Tobacco", "Transportation", "Unemployment", "United States", "Universities", "Withdrawal", "arm", "attributable mortality", "base", "cancer health disparity", "cancer prevention", "cancer risk", "cigarette smoking", "community partnership", "craving", "effective intervention", "efficacy testing", "evidence base", "experience", "food insecurity", "food security", "fruits and vegetables", "health care availability", "health disparity", "hydroxycotinine", "improved", "innovation", "mortality", "multidisciplinary", "novel", "programs", "randomized controlled design", "recruit", "reduce tobacco use", "rural African American", "rural counties", "smoking abstinence", "smoking cessation", "smoking prevalence", "social", "social disparities", "social factors", "social interventions", "social stressor", "social structure", "stressor", "tobacco exposure", "tobacco-free", "treatment group", "trend", "voucher" ], "approved": true } }, { "type": "Grant", "id": "14896", "attributes": { "award_id": "1U19AI181767-01", "title": "P1-Genomic determinants of epidemic success in respiratory viruses", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2024-06-14", "end_date": "2027-05-31", "award_amount": 1728873, "principal_investigator": { "id": 31584, "first_name": "Adam", "last_name": "Lauring", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "– Project 1 (Virus) Respiratory viruses impose a significant public health burden, in large part due to their rapid evolution and ability to evade host immunity. Influenza, COVID-19, and now RSV infection, are all vaccine-preventable diseases, yet our current system of genomic surveillance is limited by significant knowledge gaps in forecasting new antigenic drift mutations and remarkably little attention to determinants of within-host and population-level viral fitness outside of antigenic sites. The long-term goal of this research is to advance the field of virus genomics by improving inference of natural selection in genomic surveillance data. The core objective of this project is to combine large-scale genomic surveillance and functional genomics to define determinants of epidemic success in three respiratory viruses. Preliminary data demonstrate: (i) a system for genomic surveillance of SARS-CoV- 2, influenza, and RSV across four major health systems in Michigan that serve a racially, geographically, and socioeconomically diverse population; and (ii) Novel laboratory approaches to measuring an array of viral phenotypes. This project will take an integrated bidirectional approach, in which genomic surveillance is used to identify strains and mutations for experimental analysis, and in which functional genomics data are used to improve population-level inference of adaptive viral evolution. Key knowledge gaps in forecasting antigenic drift and selection elsewhere in the genome will be addressed in three specific aims: (Aim 1) Develop a Bayesian model to identify SARS-CoV-2 mutations positively selected within hosts. A comprehensive dataset of fitness values for amino acid substitutions in the Omicron spike protein will be used to parameterize a Bayesian model for identifying positively selected mutations within hosts and applied to deep sequence data of serially sampled individuals. (Aim 2) Use mutational antigenic profiling (MAP) of the RSV fusion (F) protein to define and anticipate antigenic drift. High throughput MAP will precisely identify immune selection on all mutations in F, making it possible to generate complete maps of antibody selection. Targeted epitopes and antibody escape mutations will be compared using sera from unvaccinated adults with prior infection, vaccinated adults with prior infection, and vaccinated pregnant women. (Aim 3) Leverage influenza virus genomic surveillance to identify determinants of epidemic success. Phylodynamic models will be applied to regional whole genome surveillance data to identify strains and mutations conferring a population-level fitness advantage. These will be further evaluated in laboratory and animal models. This project is innovative because it will combine large-scale genomic surveillance and functional genomics to define antigenic drift and other determinants of epidemic success in influenza virus, SARS-CoV-2, and RSV. While different approaches are taken for each virus, they are universally applicable and will advance the field. By addressing knowledge gaps for these three respiratory viruses, this project will provide a foundation for more accurate prediction of emerging strains and the development of more protective vaccines.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5946", "attributes": { "award_id": "5U19AI131130-05", "title": "Engineering a human brain organoid-based platform to study neurotropic viruses", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 20288, "first_name": "KAITLYN MELISSA", "last_name": "Morabito", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-04-01", "end_date": "2023-03-31", "award_amount": 1499160, "principal_investigator": { "id": 20289, "first_name": "Guo-li", "last_name": "Ming", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 20290, "first_name": "HENGLI", "last_name": "TANG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overview Modeling of infectious diseases that affect the human central nervous system (CNS), such as those associated with Zika virus (ZIKV) and West Nile virus (WNV), has been challenging due to the inaccessibility of the relevant cell types. Reprogramming human somatic cells, such as skin fibroblasts, into induced pluripotent stem cells (iPSCs) provides a genetically tractable and renewable source of human neural cell populations. We can differentiate these iPSCs into many of the cell types critical for the study of neurotropic viruses, but typically this is performed in monolayer cultures to allow for more control and to generate more homogeneous cell populations, but this methodology lacks the self-organizing properties and interactive dynamics among different cell populations observed during organ development. Recently, more complex structures resembling whole developing organs, named organoids, have been generated from human iPSCs via 3D culturing methods. This emerging new technology has the potential to significantly advance our understanding of infectious diseases and for future therapeutic development. The success of this approach, however, critically depends on how well organoids mimic biological structures, recapitulate human physiology and disease pathology, and incorporate components critical to disease and human host responses. We propose to develop a robust platform for organoid development to model brain development that can be adopted by single labs for basic research, and is amenable to translational studies and drug development and testing. Our Research Center is comprised of three Research Projects, a Scientific Core, and an Administrative Core led by experts in virology, stem cell biology, neural development, and bioengineering. We will focus on ZIKV and WNV, two neurotropic flaviviruses, to develop our organoid platform, which can then be used by the scientific community to investigate other infectious diseases that affect the nervous system. Importantly, ZIKV and WNV are thought to impact the CNS at different stages of development, with ZIKV having been recently implicated as being causal for microcephaly in some pregnant women. This affords us the opportunity to develop an organoid platform with proof-of-principle testing with viruses suspected to have cell type- and stage-specific tropism. Project 1 will focus on technology development to generate more mature organoids and the scaling up of robust assays to perform medium-throughput compound testing. Project 2 will focus on ZIKV infections in early stage organoids and Project 3 will evaluate co-culture organoid systems to model WNV infections in later stage organoids. The projects will be supported by a Scientific Core that will provide cells and on-site training to Projects 2 & 3, as well as optimization of differentiation protocols and bioinformatics analyses. Finally, the Administrative Core will provide logistical support to facilitate collaborations among investigators and to coordinate the timely release of results and resources to the scientific community.", "keywords": [ "3-Dimensional", "Ache", "Address", "Adherent Culture", "Adopted", "Adult", "Affect", "Americas", "Animals", "Arthralgia", "Basic Science", "Bioinformatics", "Biological", "Biological Assay", "Biology", "Biomedical Engineering", "Brain", "Cell model", "Cell physiology", "Cells", "Centers for Disease Control and Prevention (U.S.)", "Central Nervous System Infections", "Central Nervous System Viral Diseases", "Cerebrum", "Coculture Techniques", "Collaborations", "Communicable Diseases", "Communities", "Complex", "Custom", "Data", "Decision Making", "Development", "Diarrhea", "Disease", "Disease Outbreaks", "Encephalitis", "Engineering", "Epidemic", "Exanthema", "Fibroblasts", "Flavivirus", "Flavivirus Infections", "Fostering", "Future", "Generations", "Goals", "Headache", "Human", "Immune response", "Infectious Diseases Research", "Institutes", "Intervention", "Laboratories", "Lead", "Logistics", "Meningitis", "Methodology", "Methods", "Microcephaly", "Mitotic", "Modeling", "Molecular", "Names", "Nervous system structure", "Neuraxis", "Neurologic", "Neurological outcome", "Neurons", "Organ", "Organoids", "Pathology", "Pharmaceutical Preparations", "Physiology", "Population", "Pregnant Women", "Proliferating", "Property", "Protocols documentation", "Rapid diagnostics", "Research", "Research Personnel", "Research Project Grants", "Resources", "Site", "Skin", "Somatic Cell", "Source", "Standardization", "Structure", "System", "Technology", "Testing", "Therapeutic Intervention", "Time", "Training", "Translational Research", "Tropism", "Validation", "Viral", "Viral Pathogenesis", "Virus", "Vomiting", "West Nile viral infection", "West Nile virus", "ZIKV infection", "Zika Virus", "base", "cell type", "cost", "data resource", "data sharing", "design", "differentiation protocol", "drug development", "drug testing", "fetal", "flexibility", "functional outcomes", "global health", "human stem cells", "human tissue", "in vitro Model", "induced pluripotent stem cell", "infectious disease model", "member", "molecular pathology", "nerve stem cell", "neurodevelopment", "neurotropic", "neurotropic virus", "new technology", "organ growth", "programs", "response", "scale up", "screening", "stem cell biology", "stem cell differentiation", "stem cell model", "success", "technology development", "therapeutic development", "therapeutic evaluation", "therapeutically effective", "three dimensional cell culture", "translat" ], "approved": true } }, { "type": "Grant", "id": "15243", "attributes": { "award_id": "1U19AI181968-01", "title": "The UCI Vaccines for Pandemic Preparedness Center (VPPC)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 31830, "first_name": "Genevieve Anne", "last_name": "Holzapfel", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-20", "end_date": "2027-07-31", "award_amount": 33116067, "principal_investigator": { "id": 31831, "first_name": "PHILIP Louis", "last_name": "FELGNER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall: The UCI Vaccines for Pandemic Preparedness Center (VPPC) The Mission: \"To contribute to human health and well-being by developing agile, safe, effective and accessible vaccines that protect the vulnerable against future pathogens of pandemic importance and by educating the next generation of vaccine scientists that will tackle such challenges.” Joshua Lederberg envisioned the world as a battlefield between microbes and man, famously saying, “The future of humanity and microbes likely will unfold as episodes of a suspense thriller that could be titled Our Wits Versus Their Genes” (Lederberg, 2000). Although the genes of the microbial world have been evolving much longer than our wits, we have come up with efficient ways to respond to infectious diseases, but regrettably evolving microorganisms keep managing to challenge and outsmart us. The latest COVID episode in this series sensitized the world again to the importance of learning from the outbreak experience and challenges us to better prepare for the next one. The 100 Days Mission (100DM), endorsed by government and non-government organizations worldwide is a proposed response to the next “Disease X” by making safe, and effective vaccines available within 100 days of the pathogen’s identification. Achieving that goal could defuse the threat of a pathogen with pandemic potential. The International Pandemic Preparedness Secretariate (IPPS), the Coalition for Epidemic Preparedness Innovations (CEPI), the HHS Administration for Strategic Preparedness and Response (ASPR Next) and the NIH/NIAID have embraced the concept of studying prototype pathogens as a critical element of preparedness. By developing vaccines on rapid-response platforms against examples of a given viral genus or family, researchers can address scientific challenges characteristic of that family in advance, providing an important head start on developing vaccines against related threats. Universal programmable vaccine platforms that can be rapidly employed against broad virus families can be evaluated in clinical trials to provide confidence in their safety, and manufacturing, and regulatory considerations can be managed ahead of the next outbreak. The UC Irvine Vaccines for Pandemic Preparedness Center (VPPC) aims to conduct basic and translational research to develop vaccines against prototype members of the Bunyavirus, Paramyxovirus and Picornavirus families with demonstrated immunogenicity and efficacy in animal models. Two universal, programmable, rapid response vaccine platforms will be characterized and compared in this study: the i) Adjuvanted Recombinant Protein (ARP) Vaccine, and ii) mRNA/Lipid Nanoparticle (LNP) Vaccine. Such prototype vaccines will need to be tested in advance, at a minimum, for clinical safety and immunogenicity, and efficacy where possible, so that emerging viruses in the same family can be rapidly and safely deployed. Gathering such data and experience will build confidence in these rapid response platforms and inform regulators as they make decisions about the emergency authorization of vaccines against related pathogens.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6659", "attributes": { "award_id": "5UG4LM013725-02", "title": "NNLM Region 5: Reaching More People in More Ways", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Library of Medicine (NLM)" ], "program_reference_codes": [], "program_officials": [ { "id": 22319, "first_name": "LYNDA R", "last_name": "HARDY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-05-01", "end_date": "2026-04-30", "award_amount": 1301788, "principal_investigator": { "id": 22320, "first_name": "Tania P", "last_name": "Bardyn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall, NNLM Region 5 RML/University of Washington The University of Washington will operate a Regional Medical Library (RML) for the Network of the National Library of Medicine (NNLM) Region 5 (AK, CA, HI, NV, OR, WA and U.S. Territories and Freely Associated States in the Pacific). Health professionals, librarians and communities are facing complex public health challenges, including COVID-19, rising unemployment, and increasing food and housing insecurity. To address these barriers, in May 2021, the RML will launch Reaching More People in More Ways, an innovative regional medical library program, to advance data driven health, health equity and health literacy by offering NNLM services, funding and training through national and regional partnerships. The major aims of this program are: Aim 1: to collaborate with Network member organizations and regional, state and local partners, who in turn diffuse culturally and linguistically appropriate resources with the communities they serve; Aim 2: to teach health professionals and librarians in national and regional education programs more about their roles in providing equitable access to high quality health information by promoting NLM resources; Aim 3: to support inclusive programming that addresses race and ethnicity; sexual and gender minorities; cognitive and physical abilities; religious background or identification; socio-economic status (past and current); education level, health literacy, and linguistic needs; geographic location including underrepresented populations from medically underserved areas; and other factors or demographics that create unequal access to the highest level of health; Aim 4: to increase NNLM membership with health advocacy organizations that create positive change through direct outreach and services to vulnerable populations; Aim 5: to partner with new and existing organizations to advance data literacy and bioinformatics competencies to the widest audience possible; and Aim 6: to address technology needs, and digital access with a focus on underrepresented communities. The results will maximize use of NLM programs and resources to accelerate discovery and advance public health in Region 5.", "keywords": [ "Address", "Alaska", "Award", "Bioinformatics", "COVID-19", "California", "Cognitive", "Collaborations", "Communities", "Community Health", "Competence", "Complex", "Data", "Development", "Diffuse", "Education", "Educational Background", "Emergency Situation", "Ethnic Origin", "Food", "Funding", "Funding Opportunities", "Gender Identity", "Geographic Locations", "Geography", "Hawaii", "Health", "Health Professional", "Health Status", "Housing", "Information Resources", "Information Services", "Librarians", "Linguistics", "Medical Libraries", "Medically Underserved Area", "Nevada", "Oregon", "Persons", "Public Health", "Race", "Religion and Spirituality", "Research Personnel", "Resources", "Role", "Services", "Sex Orientation", "Sexual and Gender Minorities", "Socioeconomic Status", "Technology", "Time", "Training", "Underrepresented Populations", "Unemployment", "United States National Library of Medicine", "Universities", "Vulnerable Populations", "Washington", "Work", "advocacy organizations", "biological sex", "data literacy", "demographics", "digital", "first responder", "gender expression", "health data", "health equity", "health literacy", "improved", "innovation", "learning progression", "member", "outreach services", "programs", "service engagement", "training opportunity" ], "approved": true } }, { "type": "Grant", "id": "8263", "attributes": { "award_id": "1UG4LM013725-01", "title": "NNLM Region 5: Reaching More People in More Ways", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Library of Medicine (NLM)" ], "program_reference_codes": [], "program_officials": [ { "id": 21523, "first_name": "LYNDA R", "last_name": "HARDY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-05-01", "end_date": "2026-04-30", "award_amount": 1343107, "principal_investigator": { "id": 22320, "first_name": "Tania P", "last_name": "Bardyn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall, NNLM Region 5 RML/University of Washington The University of Washington will operate a Regional Medical Library (RML) for the Network of the National Library of Medicine (NNLM) Region 5 (AK, CA, HI, NV, OR, WA and U.S. Territories and Freely Associated States in the Pacific). Health professionals, librarians and communities are facing complex public health challenges, including COVID-19, rising unemployment, and increasing food and housing insecurity. To address these barriers, in May 2021, the RML will launch Reaching More People in More Ways, an innovative regional medical library program, to advance data driven health, health equity and health literacy by offering NNLM services, funding and training through national and regional partnerships. The major aims of this program are: Aim 1: to collaborate with Network member organizations and regional, state and local partners, who in turn diffuse culturally and linguistically appropriate resources with the communities they serve; Aim 2: to teach health professionals and librarians in national and regional education programs more about their roles in providing equitable access to high quality health information by promoting NLM resources; Aim 3: to support inclusive programming that addresses race and ethnicity; sexual and gender minorities; cognitive and physical abilities; religious background or identification; socio-economic status (past and current); education level, health literacy, and linguistic needs; geographic location including underrepresented populations from medically underserved areas; and other factors or demographics that create unequal access to the highest level of health; Aim 4: to increase NNLM membership with health advocacy organizations that create positive change through direct outreach and services to vulnerable populations; Aim 5: to partner with new and existing organizations to advance data literacy and bioinformatics competencies to the widest audience possible; and Aim 6: to address technology needs, and digital access with a focus on underrepresented communities. The results will maximize use of NLM programs and resources to accelerate discovery and advance public health in Region 5.", "keywords": [ "Address", "Alaska", "Award", "Bioinformatics", "COVID-19", "California", "Cognitive", "Collaborations", "Communities", "Community Health", "Competence", "Complex", "Data", "Development", "Diffuse", "Education", "Educational Background", "Emergency Situation", "Ethnic Origin", "Food", "Funding", "Funding Opportunities", "Gender Identity", "Geographic Locations", "Geography", "Hawaii", "Health", "Health Professional", "Health Status", "Housing", "Information Resources", "Information Services", "Librarians", "Linguistics", "Medical Libraries", "Medically Underserved Area", "Nevada", "Oregon", "Public Health", "Race", "Religion and Spirituality", "Research Personnel", "Resources", "Role", "Services", "Sex Orientation", "Sexual and Gender Minorities", "Socioeconomic Status", "Technology", "Time", "Training", "Underrepresented Populations", "Unemployment", "United States National Library of Medicine", "Universities", "Vulnerable Populations", "Washington", "Work", "advocacy organizations", "biological sex", "data literacy", "demographics", "digital", "first responder", "gender expression", "health data", "health equity", "health literacy", "improved", "innovation", "learning progression", "member", "outreach services", "programs", "service engagement", "training opportunity" ], "approved": true } }, { "type": "Grant", "id": "6580", "attributes": { "award_id": "5P20GM103446-21", "title": "Delaware INBRE", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22040, "first_name": "KRISHAN", "last_name": "ARORA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-30", "end_date": "2024-04-30", "award_amount": 4053243, "principal_investigator": { "id": 22041, "first_name": "MELINDA K", "last_name": "DUNCAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 442, "ror": "https://ror.org/01sbq1a82", "name": "University of Delaware", "address": "", "city": "", "state": "DE", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall The overall mission of the Delaware INBRE (DE-INBRE) program is to further grow a collaborative, multidisciplinary biomedical research network in Delaware that creates and supports sustainable collaborative research programs that address strategic health issues for the State, embraces diversity, and produces a positive impact on Delaware’s workforce and economy. The DE-INBRE network consists of six Partner Institutions: the lead institution, University of Delaware; three minority- serving primarily undergraduate institutions (PUIs), Delaware State University, Delaware Technical Community College, and Wesley College; and two medical institutions, Christiana Care Health System and Nemours/Alfred I. duPont Hospital for Children. Three Affiliated Institutions joined the network in 2017, including the Wilmington Veterans Affairs Medical Center, Wilmington University, and Delaware BioScience Association. The DE-INBRE’s five administrative and scientific cores provide research support and capacity building. The Administrative and Evaluation Core manages network activities with a rigorous evaluation program. A Centralized Shared Resources Core provides state-of-the-art research instrumentation and scientific expertise via a network of core facilities. A broadly engaged Bioinformatics Core supports inter-institutional research initiatives and training needs. The Education and Professional Development Core engages Delaware’s faculty, clinicians, and a diverse population of students with exceptional mentors. Finally, the Developmental Research Project Program supports Pilot Project investigators in cancer, cardiovascular, and neuroscience thematic areas. Specific Aims 1. Grow a strong and sustainable biomedical research capability in Delaware. 2. Enhance the capacity of Delaware’s biomedical research network. 3. Embrace diversity across Delaware’s biomedical research, industrial, and patient care networks. 4. Enhance the biomedical science and technology knowledge of Delaware’s workforce.", "keywords": [ "Address", "Area", "Award", "Basic Science", "Bioinformatics", "Biological Sciences", "Biomedical Research", "Brain", "Cardiovascular system", "Clinical", "Communities", "Core Facility", "Delaware", "Development", "Disease", "Economics", "Education", "Educational workshop", "Evaluation", "Faculty", "Funding", "Goals", "Grant", "Health", "Healthcare Systems", "Heart Diseases", "Industrialization", "Institution", "Knowledge", "Lead", "Malignant Neoplasms", "Medical", "Medical center", "Mentors", "Minority", "Minority Groups", "Mission", "Neurosciences", "Occupations", "Patient Care", "Pediatric Hospitals", "Peer Review", "Pilot Projects", "Population Heterogeneity", "Postdoctoral Fellow", "Program Evaluation", "Program Research Project Grants", "Publications", "Publishing", "Research", "Research Infrastructure", "Research Personnel", "Research Support", "Resource Sharing", "Risk", "Science", "Series", "Services", "Students", "Technology", "Training", "Training Activity", "Training and Education", "Translational Research", "Underrepresented Minority", "United States Department of Veterans Affairs", "Universities", "Woman", "cardiovascular health", "career", "college", "community college", "experience", "graduate student", "human capital", "improved", "improved outcome", "instrumentation", "inter-institutional", "meeting abstracts", "multidisciplinary", "programs", "student training", "symposium", "undergraduate student" ], "approved": true } }, { "type": "Grant", "id": "14897", "attributes": { "award_id": "1U19AI181767-01", "title": "The Michigan Infectious Disease Genomics (MIDGE) Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 8282, "first_name": "Inka I", "last_name": "Sastalla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-06-14", "end_date": "2027-05-31", "award_amount": 6233451, "principal_investigator": { "id": 31584, "first_name": "Adam", "last_name": "Lauring", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31585, "first_name": "Evan", "last_name": "Snitkin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall The advent of genomic sequencing technologies has revolutionized our understanding of disease transmission, pathogen evolution, drug resistance, and virulence. Pathogens can quickly adapt to new environments and treatments, making it critical to understand the underlying genetic changes that drive this process. The proposed Michigan Infectious Disease Genomics (MIDGE) Center will feature four projects, each focused on a group of pathogens, unified by a common theme of identifying pathogen determinants of epidemic success and by a common approach that combines genomic surveillance, functional genomics, and high-throughput phenotyping assays. Project 1 examines the genomic determinants of epidemic success in SARS-CoV-2, RSV, and influenza viruses. Here, epidemic success is linked to the virus’s ability to transmit and spread within an immune population through mutations that either increase intrinsic transmissibility or allow for escape from neutralizing antibodies. Project 2 investigates the impact of genetic background on the emergence and spread of carbapenem-resistant Enterobacteriales, where epidemic success is linked not only to drug resistance genes and mutations but also to the genetic background on which they arise. Project 3 will define genetic and genomic determinants of colonization in Candida auris, an emerging fungal pathogen. The key to the epidemic success of C. auris appears to be its remarkable ability to adhere to and colonize the skin and the built environment, and this project will leverage whole genome sequencing, microbial GWAS, and functional genomic screens to identify the genetic circuitry for this trait. Project 4 uses functional genomic approaches to understand the virulence of epidemic strains of Toxoplasma gondii, which are more common in South America and cause a distinct disease from that associated with other globally dispersed lineages. Genomic surveillance of scat from wild cats will be used to further define the diversity of potentially epidemic, hypervirulent strains in this region. A Technical and Data Core will support the work of all four projects with staff bioinformaticians and research data analysts as well as Investigators with expertise in phylogenetics, high-throughput phenotyping assays, and analysis of complex data sets. The Administrative Core will leverage local strengths in training and outreach and provide an infrastructure for regulatory compliance, financial reporting, and data and resource sharing. Through successful execution of this research plan, the MIDGE Center will develop genomic methods and protocols to study infectious diseases and will advance genomics more broadly in basic and clinical research across viral, bacterial, fungal, and parasitic pathogens.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6038", "attributes": { "award_id": "3U19AI111825-08S1", "title": "Integrating innate and adaptive pathways in vaccine responses", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 20603, "first_name": "Chao", "last_name": "Jiang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-05", "end_date": "2022-03-31", "award_amount": 1500000, "principal_investigator": { "id": 20604, "first_name": "JEFFREY Victor", "last_name": "RAVETCH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 763, "ror": "https://ror.org/0420db125", "name": "Rockefeller University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall Significant progress in basic immunology research over the last three decades has resulted in numerous medical advances and dissected the general mechanisms by which the human immune system responds to foreign antigens. However, a much more substantial understanding of the coordinated molecular mechanisms involved in eliciting immunity will be required, as each viral pathogen poses unique challenges to the immune system and the elicited immune responses are characterized by substantial heterogeneity that impacts disease susceptibility and pathogenesis. Indeed, it is expected that B-cell responses against diverse viral pathogens are uniquely evolved during infection to shape the functional activity of IgG antibodies. Studies from viral infectious diseases have shown that antiviral IgG antibodies have the capacity to mediate a wide spectrum of opposing functions: (i) protective functions, including neutralization, viral opsonization, and clearance of infected cells and (ii) pathogenic activities, which enhance viral infectivity, disease susceptibility and severity; a phenomenon termed as antibody-mediated enhancement (ADE) of disease. ADE mechanisms have been previously suggested to account for susceptibility to dengue disease, as epidemiological data support that prior flavivirus infection is the major risk factor for dengue disease, implicating the presence of cross-reactive, non-neutralizing IgG antibodies to this process. Understanding the heterogeneity of IgG responses elicited upon infection or vaccination with diverse viral antigens is therefore critical for characterizing the immunological mechanisms that drive human immunity and determine the protective vs. pathogenic activity of IgG antibodies. Our Center will feature three Projects directed by Drs. Ravetch (Project 1: Fc domain effector activity in dengue disease), Nussenzweig and Rice (Project 2: Understanding B cell memory in response to diverse virus infections), and Wang (Project 3: Immunity to dengue viruses), supported by a scientific core (Core A: Transgenic mouse core) and the administrative core (Core B). Through a series of collaborative studies between the three Projects, our Center aims to study human antiviral immune responses during infection and vaccination and characterize the immune mechanisms that regulate the function of IgG antibodies in humans. More specifically, we aim to characterize the heterogeneity of IgG responses elicited upon vaccination or infection with diverse viral pathogens, including HBV and flaviviruses, like Zika and dengue. Additionally, we will dissect the ADE mechanisms by which IgG antibodies mediate disease-enhancing activities and contribute to dengue disease susceptibility and pathogenesis. These studies will provide novel insights into the mechanisms that drive protective immunity and modulate antibody function, having a broader impact on the development of vaccination strategies against infectious pathogens.", "keywords": [ "Acute", "Affinity", "Antibodies", "Antigens", "Antiviral Agents", "B-Lymphocytes", "Cell Line", "Cells", "Characteristics", "Clinical", "Communicable Diseases", "Dengue", "Dengue Infection", "Dengue Vaccine", "Dengue Virus", "Development", "Disease", "Disease susceptibility", "Engineering", "Exhibits", "Fc domain", "Flavivirus", "Flavivirus Infections", "Follow-Up Studies", "Gene Expression Profile", "Goals", "Hepatitis B Virus", "Heterogeneity", "Human", "Human Activities", "IgG1", "Immune", "Immune response", "Immune system", "Immunity", "Immunoglobulin G", "Immunologic Memory", "Immunologics", "Immunology", "In Vitro", "Individual", "Infection", "Inflammatory", "Influenza", "Leukocytes", "Mediating", "Medical", "Memory B-Lymphocyte", "Molecular", "Monoclonal Antibodies", "Mouse Strains", "Pathogenesis", "Pathogenicity", "Pathway interactions", "Patients", "Phase", "Polysaccharides", "Population", "Predisposition", "Process", "Research", "Rice", "Risk Factors", "Role", "Series", "Severity of illness", "Shapes", "Structure", "Transgenic Mice", "Vaccinated", "Vaccination", "Variant", "Viral", "Viral Antigens", "Virus Diseases", "ZIKA", "ZIKV infection", "cross reactivity", "epidemiologic data", "glycosylation", "humanized mouse", "immunological status", "immunoregulation", "in vivo", "individual response", "insight", "novel", "novel strategies", "novel vaccines", "pathogen", "pathogenic virus", "response", "severe dengue", "vaccination strategy", "vaccine response" ], "approved": true } }, { "type": "Grant", "id": "6009", "attributes": { "award_id": "3P01AI117915-07S1", "title": "Early Life Vaccination to Prevent HIV acquisition during Adolescence", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 20536, "first_name": "Anjali", "last_name": "Singh", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2015-04-01", "end_date": "2023-03-31", "award_amount": 299339, "principal_investigator": { "id": 20537, "first_name": "Kristina", "last_name": "De Paris", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 825, "ror": "", "name": "WEILL MEDICAL COLL OF CORNELL UNIV", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20538, "first_name": "Sallie R.", "last_name": "Permar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 825, "ror": "", "name": "WEILL MEDICAL COLL OF CORNELL UNIV", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "– Overall Nearly 600,000 new HIV infections occur yearly in adolescents/young adults (ages 15-24 years), the only population in which HIV infections continue to rise. The end of the HIV/AIDS epidemic will be achievable only when an effective vaccine regimen can elicit long-term protective immunity in preadolescence, prior to sexual debut. Yet, even the most promising HIV envelope (Env) vaccine platforms have failed to induce highly- protective immunity in adults in preclinical and clinical studies. Interestingly, recent studies indicate that durable, polyfunctional, and broad neutralizing antibody (bnAb) responses following HIV infection occur more frequently and are equal or more potent in infants compared to that of adults. Yet, there remains a gap in our understanding of the immunologic mechanisms associated with the rapid induction of HIV bnAb and effector antibody functions within the infant immune landscape. The overall goal of this HIVRAD renewal is to harness the unique qualities of the early life immune system for vaccine elicitation of protective HIV immunity. This work builds on our current HIVRAD Program focusing on the development of HIV Env vaccine regimens for prevention of infant HIV acquisition. We defined the optimal vaccine intervals, adjuvants, and doses to achieve maximal immunogenicity in the infant immune system, and determined that concurrent passive bnAb-active HIV Env immunization does not impair vaccine-elicited immune responses. In this renewal HIVRAD Program, we hypothesize that HIV Env vaccine platforms administered in early life and boosted in preadolescence will achieve more durable, broad, and polyfunctional immune responses and be more efficacious at prevention of sexual transmission than initiation of immunization in preadolescence. We will compare vaccine responses to two of the most promising HIV Env vaccine candidates, bnAb germline-targeting SOSIP trimers (Project 1) and lipid nanoparticle mRNA vaccines (Project 2) initiated in infancy with boosting throughout childhood to that of initiation of vaccination in preadolescence in the rhesus model (Nonhuman Primate (NHP) Core), and test their efficacy against intrarectal homologous and heterologous SHIV challenge in adolescence. We will apply systems immunology to define the immunologic, transcriptomic, and microbiologic signatures associated with the HIV Env vaccine antibody function and induction of bnAb precursors (Integrated Systems Immunology Core (ISIC)). The Administrative Core provides the full range of support for scientific, fiscal, and other programmatic management and oversight. By leveraging the extended window for maturation of vaccine-induced responses and defining the mechanistic advantages of early life immunization for effective anti-HIV responses, this Program will inform the target population and design of an HIV Env vaccine that will provide life-long protection.", "keywords": [ "AIDS/HIV problem", "Achievement", "Adjuvant", "Adolescence", "Adolescent", "Adult", "Age", "Antibodies", "Antibody Response", "Antibody-mediated protection", "Antigens", "Autologous", "B-Lymphocytes", "Cell Communication", "Cell Lineage", "Cells", "Childhood", "Clinical Research", "Collaborations", "Development", "Dose", "Epidemic", "Evolution", "Funding", "Future", "Goals", "HIV", "HIV Infections", "HIV vaccine", "HIV-1", "Human", "Human Milk", "Immune", "Immune response", "Immune system", "Immunity", "Immunization", "Immunize", "Immunoglobulin Somatic Hypermutation", "Immunologics", "Immunology", "Infant", "Infection", "Infrastructure", "Life", "Macaca mulatta", "Mediating", "Messenger RNA", "Microbiology", "Modeling", "Molecular", "Monkeys", "Passive Immunization", "Pathway interactions", "Plasma", "Population", "Prevention", "RNA vaccine", "Regimen", "Rhesus", "Risk", "Sexual Transmission", "System", "Systems Biology", "Target Populations", "Testing", "Time", "Translations", "Vaccination", "Vaccine Clinical Trial", "Vaccine Design", "Vaccines", "Vertical Disease Transmission", "Virus", "Woman", "Work", "Youth", "age group", "design", "immunogenicity", "infancy", "insight", "lipid nanoparticle", "microbial", "microbial signature", "microbiome", "microbiota", "microorganism interaction", "neutralizing antibody", "nonhuman primate", "novel", "preadolescence", "preclinical study", "predictive signature", "prevent", "programs", "response", "sexual debut", "simian human immunodeficiency virus", "transcriptome", "transcriptomics", "transmission process", "vaccination strategy", "vaccine candidate", "vaccine response", "vaccine-induced antibodies", "young adult" ], "approved": true } } ], "meta": { "pagination": { "page": 3, "pages": 1392, "count": 13920 } } }