Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=2&sort=program_reference_codes
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_reference_codes", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=program_reference_codes", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=program_reference_codes", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_reference_codes" }, "data": [ { "type": "Grant", "id": "5120", "attributes": { "award_id": "1010204", "title": "CNH/EID: The Vector Mosquito Aedes aegypti at the Margins: Sensitivity of a Coupled Natural and Human System to Climate Change", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "DYN COUPLED NATURAL-HUMAN" ], "program_reference_codes": [], "program_officials": [ { "id": 18242, "first_name": "Sarah", "last_name": "Ruth", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2010-10-01", "end_date": "2014-09-30", "award_amount": 1235153, "principal_investigator": { "id": 18246, "first_name": "Andrew", "last_name": "Monaghan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 275, "ror": "", "name": "University Corporation For Atmospheric Res", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18243, "first_name": "Mary H", "last_name": "Hayden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18244, "first_name": "Lars M", "last_name": "Eisen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18245, "first_name": "Luca Delle", "last_name": "Monache", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 275, "ror": "", "name": "University Corporation For Atmospheric Res", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will explore the ecology of Aedes (Ae.) aegypti, the mosquito that transmits dengue, yellow fever and chikungunya. We hypothesize that the combined effects of climate variability and changes made by humans to their local environment can influence key aspects of both mosquito ecology and human behavior. Studying this system as a whole will improve our ability to predict risks of mosquito vector and dengue virus exposure and the possible impacts of future climate change. \n\nDengue viruses circulate between mosquitoes and humans, causing an estimated 100 million human dengue infections annually. In the last decade, the Americas have experienced a dramatic increase in severe cases (dengue hemorrhagic fever), with devastating public health consequences. As neither vaccines nor therapeutics are yet available, mosquito control is the main option for preventing and controlling dengue outbreaks. Efforts in this area have been hindered by a poor understanding of the dengue virus transmission system at the interface between its natural and human components. Of particular concern is the potential for dengue fever to expand into areas that are presently outside transmission zones but may become vulnerable under scenarios of future climate change. For example, this potential expansion poses a risk to the ~19 million people in and near Mexico City, a high altitude \"island\" currently free of dengue but surrounded by dengue virus transmission at lower altitudes. \n\nSpecific aims of the project are to: (1) determine how weather/climate factors are related to the presence and abundance of disease-carrying mosquitoes, especially by serving as barriers to mosquitoes becoming established in an area; (2) use these results in high-resolution atmospheric models to develop a predictive model for future mosquito range expansion; (3) determine which aspects of human behavior and attributes of man-made environments are most closely related to Ae. aegypti presence and abundance; (4) employ state-of-the-science data assimilation procedures to validate, refine, and define uncertainty in this modeling framework. Key aspects of this coupled natural and human system will be studied along an altitudinal transect in Mexico, ranging from coastal, low-elevation environments with well established vector mosquito populations and intense dengue virus transmission to high-elevation, mountainous areas which currently are free of the mosquito vector and local virus transmission. The team of experts from Mexico and the United States includes climatologists, vector ecologists, modelers and medical anthropologists.\n\nThe project will contribute essential insights into the ongoing debate about climate change and infectious disease relationships, extending beyond the explicit vector ecology and geographic boundaries of this study. The work will provide quantitative knowledge that can be used to develop novel strategies to control Ae. aegypti in the face of future threats to system resilience. Further, it will provide training for a postdoctoral fellow in climate modeling and spatial risk modeling at both Colorado State University and the National Center for Atmospheric Research and involvement and in situ training of university and secondary school students in data collection. Through \"participatory epidemiology\", local community members will learn how to use environmental observation and data collection as a means of community empowerment.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "768", "attributes": { "award_id": "2050640", "title": "Planning Virtual Strategies to Prepare Science and Mathematics Teachers in Mississippi", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)" ], "program_reference_codes": [], "program_officials": [ { "id": 1805, "first_name": "Susan", "last_name": "Carson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-03-01", "end_date": "2023-02-28", "award_amount": 124992, "principal_investigator": { "id": 1809, "first_name": "Mitchell M", "last_name": "Shears", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 396, "ror": "https://ror.org/01ecnnp60", "name": "Jackson State University", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 1806, "first_name": "Abu O", "last_name": "Khan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 1807, "first_name": "Alicia K", "last_name": "Jefferson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 1808, "first_name": "Nadine", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 396, "ror": "https://ror.org/01ecnnp60", "name": "Jackson State University", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true }, "abstract": "This project aims to serve the national need for skilled secondary science and mathematics teachers in high-need school districts. To do so, the project seeks to lay the foundation for secondary-education certification programs adapted to the novel demands of pre- and post-COVID teaching/learning environments. Conceived initially as a response to the COVID-19 pandemic, the project aims to use technology and virtual approaches to deliver remote learning opportunities for future teachers. As such, the project will enable Jackson State University to explore the feasibility of a large-scale effort to increase use of evidence-based, distance-learning strategies in teacher education. Examples of strategies include virtual simulations, digital credentialing, and online social and emotional learning. The work will be situated in the urban setting of the Mississippi State capital. This project at Jackson State University includes partnerships with Hinds Community College and Jackson Public Schools, a high-need school district. The long-term goal of this collaborative effort is plan how to recruit, support, and graduate teachers who will help meet the shortage of science and mathematics teachers at high-need schools often staffed by rotating long- and short-term substitute teachers. The project builds on the conceptual framework of Jackson State’s College of Education and Human Development vision of the “responsive educator” who provides and embodies: 1) a Committed Response; 2) a Knowledgeable Response; 3) a Skillful Response; and 4) a Professional Response. Additionally, the project builds on the current infrastructure of the University’s Physics and Mathematics Education curriculum. The goals of this Capacity Building project are to: 1) develop evidence-based innovative models and strategies for recruiting, preparing, and supporting teachers; 2) create plans for collecting data to determine need, interest, and capacity for increasing STEM teacher development; and 3) establish the infrastructure for preparing a Track 1: Scholarship & Stipend proposal in the future. This Capacity Building project is supported through the Robert Noyce Teacher Scholarship Program (Noyce). The Noyce program supports talented STEM undergraduate majors and professionals to become effective K-12 STEM teachers and experienced, exemplary K-12 teachers to become STEM master teachers in high-need school districts. It also supports research on the persistence, retention, and effectiveness of K-12 STEM teachers in high-need school districts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "7168", "attributes": { "award_id": "3R01DK115728-03S1", "title": "Structure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and Therapy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 11708, "first_name": "Patricia", "last_name": "Greenwel", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-08-15", "end_date": "2023-06-30", "award_amount": 553964, "principal_investigator": { "id": 22963, "first_name": "Kenan Christopher", "last_name": "GARCIA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 6819, "first_name": "CALVIN J", "last_name": "KUO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened global health. The severity of disease and rising number of deaths from SARS-CoV-2 have raised an urgent need for effective therapies. Besides respiratory symptoms, 20-50% of patients exhibit gastrointestinal symptoms such as diarrhea and emesis. In addition, clinical evidence shows that viral RNA can be found in rectal swabs, indicating that the intestine may be a critical target of SARS-CoV-2 infection. In this proposal, we engineer novel high-affinity blocking agents for known entry receptors of SARS-CoV-2 to prevent infection of human intestinal cells and pursue a longer-term goal of structure-based discovery of novel receptor targets. Aim 1 designs blocking agents that target the known interaction of SARS-CoV-2 S protein with its primary entry receptor ACE2 (angiotensin-converting enzyme 2), as well as with a novel co-receptor, CD147 (accessory protein for monocarboxylate transporters), both of which are expressed in human small intestinal and colon epithelial cells. In Aim 1 we will engineer an ACE2/CD147 bi-specific agent that can simultaneously target both SARS-CoV-2 S protein receptors to improve the efficiency and specificity of viral blockade. We utilize in vitro protein evolution by yeast cell surface display to generate high-affinity ACE2 and CD147 ECDs with improved affinity for SARS-CoV-2 S protein versus the wild- type ECDs These will be combined into a single bispecific agent containing both ACE2 and CD147 affinity-matured ECDs and assayed in human intestinal organoids. In particular, we deploy intestinal organoids with a “flipped polarity” where the apical ACE2-expressing aspect faces outwards towards the surrounding ECM/media instead of towards the interior lumen to better model physiologic viral infection. In Aim 2, we will screen a CRISPRa activating library for additional human SARS-CoV-2 secretome targets. The SARS-CoV-2 secretome, i.e. virus-encoded secreted or surface-exposed transmembrane proteins, also facilitates infection of host cells and provides novel targets for SARS- CoV-2 therapeutics. This proposal leverages expertise of Chris Garcia (Multi-PI of the parental R01) in protein engineering, immunotherapeutics, and structural biology with Calvin Kuo (Multi-PI of the parental R01) expertise in organoid generation and disease modelling to design targeted therapeutics for SARS-CoV-2. We also utilize collaboration from the Manuel Amieva and Catherine Blish groups in organoid apical-basal polarity inversion and BSL3 SARS-CoV-2 infection, respectively.", "keywords": [ "2019-nCoV", "Affinity", "Apical", "Biological Assay", "Biomedical Engineering", "COVID-19", "COVID-19 pandemic", "Cell Therapy", "Cell surface", "Cells", "Cessation of life", "Clinical", "Collaborations", "Colon", "Diarrhea", "Disease", "Disease model", "Engineering", "Epithelial Cells", "Evolution", "Exhibits", "Extracellular Matrix", "Face", "Generations", "Goals", "Human", "Immunotherapeutic agent", "In Vitro", "Infection", "Infection prevention", "Integral Membrane Protein", "Intestines", "Libraries", "Organoids", "Patients", "Peptidyl-Dipeptidase A", "Protein Engineering", "Proteins", "Respiratory Signs and Symptoms", "SARS coronavirus", "Severity of illness", "Small Intestines", "Specificity", "Structure", "Surface", "Swab", "Therapeutic", "Viral", "Virus", "Virus Diseases", "Vomiting", "Yeasts", "base", "cellular engineering", "design", "effective therapy", "gastrointestinal symptom", "global health", "improved", "novel", "pandemic disease", "physiologic model", "prevent", "receptor", "rectal", "respiratory", "stem cell biology", "structural biology", "targeted agent", "targeted treatment", "viral RNA" ], "approved": true } }, { "type": "Grant", "id": "6144", "attributes": { "award_id": "3R01MD012421-03S1", "title": "Influence of patient-centered HIV care on retention and viral suppression disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 20877, "first_name": "Richard", "last_name": "Berzon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-01-29", "end_date": "2023-11-30", "award_amount": 268162, "principal_investigator": { "id": 20878, "first_name": "MARY JO JO", "last_name": "TREPKA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 207, "ror": "https://ror.org/02gz6gg07", "name": "Florida International University", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "People with human immunodeficiency virus (HIV) are at increased risk of COVID-19 complications due to underlying immunosuppression and comorbidities and thus can significantly benefit from COVID-19 vaccination. People with HIV (PWH) are also more likely to belong to racial/ethnic minorities that have been disproportionately burdened by the COVID-19 pandemic and are currently underrepresented among vaccinated individuals. The objective of this study is to identify points of intervention to increase COVID-19 vaccine uptake among African American, Hispanic, and Haitian PWH. To achieve this objective, we will conduct a mixed methods study involving a sample of 129 Hispanics, 116 African Americans and 53 Haitians with HIV who were previously interviewed from October 2020 to January 2021 about the effect of the COVID- 19 pandemic on their health and wellbeing and their HIV care (Wave 1). The current supplement (Wave 2) will extend the previous study by determining COVID-19 vaccine uptake and factors associated with vaccine uptake. The survey questions will collect quantitative data about factors associated with vaccination using both the Health Belief Model (e.g., perceived susceptibility to COVID-19, perceived severity of COVID-19, perceived barriers and benefits of COVID-19 vaccination, and cues to action) and the Social Ecological Model (i.e., potential intrapersonal, interpersonal, and community/institutional-level factors associated with COVID-19 vaccine uptake). Data from the survey will also be used to identify the extent to which COVID-19 vaccination improves psychosocial (e.g., COVID-19 related worry) and socioeconomic (e.g., reduced income) stressors. Furthermore, we will conduct exploratory analyses to assess the association between vaccination and retention in HIV care and viral suppression. Subsequently, we will ask a sample of vaccinated and unvaccinated survey respondents to participate in semi-structured in-depth interviews to clarify quantitative findings and identify points of intervention. Findings from this study will guide vaccination promotion messages for racial/ethnic minorities with HIV, guide vaccination delivery methods (e.g., vaccination in HIV care settings), and elucidate the potential role of COVID-19 vaccination in improving the health and wellbeing of people with HIV.", "keywords": [ "African American", "Anxiety", "COVID-19", "COVID-19 mortality", "COVID-19 pandemic", "COVID-19 severity", "COVID-19 vaccination", "COVID-19 vaccine", "Caring", "Case Manager", "Client", "Communities", "Cross-Sectional Studies", "Cues", "Data", "Depressed mood", "Feeling", "HIV", "Haitian", "Health", "Hispanics", "Hour", "Household", "Immunosuppression", "Income", "Individual", "Intervention", "Interview", "Loneliness", "Medical", "Methods", "Minority Groups", "Modeling", "Not Hispanic or Latino", "Occupations", "Participant", "Personal Satisfaction", "Population", "Predisposition", "Recommendation", "Reporting", "Respondent", "Risk", "Role", "Sampling", "Social Network", "Structure", "Surveys", "Telephone", "Vaccinated", "Vaccination", "Viral", "Virus Diseases", "anxious", "care providers", "comorbidity", "ethnic minority population", "follow-up", "health belief", "improved", "pandemic disease", "patient oriented", "programs", "psychosocial", "racial and ethnic", "severe COVID-19", "social", "social norm", "socioeconomics", "stressor", "vaccine acceptance" ], "approved": true } }, { "type": "Grant", "id": "6656", "attributes": { "award_id": "3R41CA254557-01A1S2", "title": "PRANAYAMA BASED MOBILE APP FOR BREAST CANCER SURVIVORSHIP: I-CORPS SUPPLEMENT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22312, "first_name": "Patricia A", "last_name": "Weber", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-06-01", "end_date": "2023-05-31", "award_amount": 55000, "principal_investigator": { "id": 22313, "first_name": "SUNDARAVADIVEL", "last_name": "BALASUBRAMANIAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1484, "ror": "", "name": "PRANASCIENCE INSTITUTE LLC", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1484, "ror": "", "name": "PRANASCIENCE INSTITUTE LLC", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Cancer remains the second leading cause of deaths in the U.S. Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases in the survival rate of cancer patients. As cancer becomes a chronic but manageable disease for thousands of survivors, the long-term physical and psychological side effects of treatment protocols is becoming more apparent, as is the impact of these issues on disease-free or overall survival. As a result of this changing landscape, survivorship care programs and approaches that incorporate non-pharmacological lifestyle and mind-body interventions are becoming increasingly critical components of the patient treatment pathway. In this regard, integrative approaches such as yogic breathing (YB), a collection of techniques to voluntarily regulate breathing, have emerged as an effective complementary therapy for cancer patients. YB is well-established to induce strong relaxation responses via vagal and parasympathetic stimulation. YB is easy to practice using virtual tools such as mobile apps especially during the current scenario of COVID-19 pandemic and social distancing. In this application, PranaScience seeks to develop a novel group video app for YB that is optimized for home-based delivery of a proscribed YB program that is maximally effective in promoting peer support, and relieving symptomatic conditions associated with cancer treatment and survivorship. This intervention is based on compelling preliminary data generated by the PI of this proposal demonstrating that specific YB exercises induce alterations in the levels of proteins associated with tumor suppression, immune regulation, neuromodulation, and stress response/ inflammation, as well as pilot studies performed in cancer survivors and other patient/general populations indicating that participants are interested in a YB intervention and perceive improvements in well-being after YB sessions. In this Phase I STTR, PranaScience (1) has built a first production version of a culturally neutral group video YB app and (2) partners with the Medical University of South Carolina (MUSC) to pilot test the YB app in breast cancer survivors to evaluate adherence, feasibility, and acceptability of the app to support symptom management. App usage data is collected and used to evaluate adherence to the program, and acceptability for symptom management will be evaluated using a series of defined biobehavioral measures at baseline and following a 12-week implementation period. Exploratory salivary and fingernail biomarker analysis focused on tumor suppressors, inflammatory cytokines, proteome level alterations, and stress hormones will be performed at baseline and at week 12. Structured, focus group interviews of study participants will be used to assess technology perception/ program feasibility and will inform future design optimizations. Information from the I-Corps supplemental work will be used to refine app in preparation for large-scale evaluation in Phase II, and for commercialization purposes through customer discovery interviews.", "keywords": [ "Adherence", "American Cancer Society", "Antineoplastic Protocols", "Behavioral", "Biological Markers", "Breast Cancer survivor", "Breast Cancer survivorship", "Breathing", "Breathing Exercises", "COVID-19 pandemic", "Cancer Etiology", "Cancer Patient", "Cancer Survivor", "Cancer Survivorship", "Caregivers", "Caring", "Cause of Death", "Cessation of life", "Chronic", "Collection", "Communities", "Complementary therapies", "Computer software", "Control Groups", "Custom", "Data", "Development", "Disease", "Disease Management", "Early Diagnosis", "Early treatment", "Equipment and supply inventories", "Evaluation", "Evidence based intervention", "Exertion", "Fibrinogen", "Focus Groups", "Frequencies", "Funding", "Future", "Gene Expression", "General Population", "Goals", "Group Interviews", "Health", "Home", "Hormones", "Individual", "Inflammation", "Inflammatory", "Innovation Corps", "Institutes", "Integrative Medicine", "Intervention", "Interview", "Length", "Life", "Life Style", "Link", "Lung", "Malignant Neoplasms", "Measures", "Medical", "Meditation", "Mental Depression", "Metabolism", "Methods", "Mind-Body Intervention", "Modality", "Online Systems", "Outcome", "Participant", "Pathway interactions", "Patient Self-Report", "Patients", "Perception", "Personal Satisfaction", "Phase", "Pilot Projects", "Preparation", "Production", "Program Acceptability", "Proteins", "Proteome", "Psychological Side Effects", "Quality of life", "Radiation therapy", "Randomized", "Rehabilitation therapy", "Relaxation", "Resources", "Risk", "Salivary", "Secondary to", "Series", "Small Business Technology Transfer Research", "Social Distance", "South Carolina", "Stress", "Structure", "Structure of nail of finger", "Supportive care", "Surveys", "Survival Rate", "Survivors", "Symptoms", "System", "Techniques", "Technology", "Testing", "Time", "Treatment Protocols", "Treatment Side Effects", "Tumor Suppression", "Tumor Suppressor Proteins", "Universities", "Virtual Tool", "Visual", "Visual Aid", "Woman", "Work", "Yoga", "attentional control", "base", "biobehavior", "biological adaptation to stress", "cancer site", "cancer therapy", "cognitive process", "cohort", "commercialization", "cytokine", "design", "ethnic minority population", "evidence base", "healthy lifestyle", "healthy volunteer", "immunoregulation", "improved", "interest", "intervention delivery", "malignant breast neoplasm", "mobile application", "n" ], "approved": true } }, { "type": "Grant", "id": "6912", "attributes": { "award_id": "1IK2RX003546-01A2", "title": "Enhanced Home-Based Exercise Therapy for Peripheral Arterial Disease through Mobile Health and Remote Monitoring", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2026-09-30", "award_amount": null, "principal_investigator": { "id": 22750, "first_name": "Arash", "last_name": "Harzand", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "An estimated 8.5 million Americans (or 7% of US adults) and nearly 10% of veterans are estimated to have peripheral arterial disease (PAD). Significantly debilitating and negatively impacting quality of life, the primary symptom of PAD is claudication (reproducible leg pain with ambulation) that leads to impaired mobility, loss of functional independence, and a heightened risk for amputation. Veterans are at an increased risk of developing symptomatic PAD due to their disproportionately high rates of PAD risk factors such as diabetes, smoking, and hypertension, the most prominent PAD risk factors. Supervised exercise therapy is proven to decrease claudication and enhance mobility in PAD; however, fewer than 25% of eligible patients enroll. Participation in this facility-based program requires travel to a rehabilitation center 3 times per week for 12-weeks, which can be burdensome and costly for Veterans, many of whom live in rural areas and on fixed incomes. There is, therefore, a need to develop a convenient and effective alternative exercise rehabilitation program for Veterans with PAD, particularly in light of safety considerations now associated with this population’s travel to group facilities in the current COVID pandemic. A promising approach to increase access to exercise rehabilitation for PAD is remote, home-based exercise therapy (HBET). Our group has successfully delivered a smartphone-enabled HBET program to Veterans with coronary artery disease with a 3-fold increase in participation and high satisfaction (80%). To this end, we are committed to utilizing technology innovations to implement HBET for Veterans with PAD successfully. HBET programs combine self-led walking exercises with health coaching and exercise tracking with a wearable activity monitor. Adapting HBET to PAD is difficult, however, due to the added complexity of an exercise prescription that requires the patient to walk until they experience near-maximal leg pain. Even with active coaching, successfully implementing HBET for PAD with long-term adherence has been difficult in the past. Our goal, therefore, is to leverage newer mobile health (mHealth) tools to adapt HBET for PAD. We propose to test our technology-enhanced approach for HBET by partnering with a successful VA lifestyle program, MOVE!, which has demonstrated success in achieving sustained weight loss and reduced diabetes onset through lifestyle modification. As increased physical activity is a core element of MOVE!, participation may help increase adherence with HBET for PAD. Our newly proposed program, Smart MOVE!, will be a multi-component program featuring a tailored version of MOVE! and a novel mHealth device called the LifeQ to improve convenience, access, and adherence to HBET for PAD. Aim 1 (Years 1-2): Identify barriers and facilitators to MOVE! participation among Veterans with PAD. Aim 2 (Years 1-2): Evaluate the feasibility of the LifeQ device to monitor exercise during HBET Aim 3 (Years 2-5): Determine the feasibility of proceeding with Smart MOVE! through a pilot randomized trial. As a VA physician actively treating Veterans with PAD, I have seen first-hand the challenges they face in accessing guideline-directed treatments such as supervised exercise. This study will lay the groundwork and provide evidence to proceed with Smart MOVE!, a much-needed patient-centered exercise rehabilitation program for PAD. Additionally, the proposed training plan will support my progress towards becoming an independent VA rehabilitation clinician-scientist focused on improving care quality and treatment outcomes for Veterans with PAD.", "keywords": [ "Accelerometer", "Activities of Daily Living", "Adherence", "Adult", "Affect", "American", "Amputation", "Behavioral", "Body Weight decreased", "COVID-19 pandemic", "Cardiac rehabilitation", "Cellular Phone", "Clinical", "Complex", "Coronary Arteriosclerosis", "Data", "Devices", "Diabetes Mellitus", "Elements", "Enhancement Technology", "Enrollment", "Exercise", "Exercise Therapy", "Face", "Goals", "Gold", "Guidelines", "Health", "Health Technology", "Home", "Hospitals", "Hypertension", "Impairment", "Income", "Indirect Calorimetry", "Intervention", "Interview", "Leadership", "Leg", "Life Style", "Life Style Modification", "Light", "Measurement", "Monitor", "Myocardial Infarction", "Oxygen Consumption", "Pain in lower limb", "Patient Education", "Patients", "Peripheral arterial disease", "Physical activity", "Physicians", "Population", "Provider", "Quality of Care", "Quality of life", "Rehabilitation Centers", "Rehabilitation therapy", "Reproducibility", "Resolution", "Risk", "Risk Factors", "Safety", "Scientist", "Smoking", "Stroke", "Structure", "Supervision", "Symptoms", "Technology", "Testing", "Time", "Training", "Travel", "Treatment outcome", "Vertebral column", "Veterans", "Walking", "aged", "base", "behavior change", "claudication", "cost", "design", "evidence base", "exercise prescription", "exercise program", "exercise regimen", "exercise rehabilitation", "experience", "functional independence", "functional loss", "functional outcomes", "high risk", "improved", "improved mobility", "informant", "innovation", "mHealth", "mortality risk", "multi-component intervention", "novel", "patient oriented", "primary outcome", "programs", "randomized trial", "remote monitoring", "rural area", "satisfaction", "success", "symptomatic improvement", "tool" ], "approved": true } }, { "type": "Grant", "id": "4096", "attributes": { "award_id": "1607069", "title": "2016 Cellular & Molecular Fungal Biology GRC, Plymouth, New Hampshire, June 19-24, 2016", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [ { "id": 13758, "first_name": "Michael", "last_name": "Mishkind", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-07-01", "end_date": "2017-06-30", "award_amount": 15000, "principal_investigator": { "id": 13759, "first_name": "Amy", "last_name": "Gladfelter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will facilitate the attendance and participation of early career scientists in the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 19-24, 2016. The goal of the conference is to disseminate information about fungal biology among an interdisciplinary group of researchers, and to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are essential parts of the terrestrial nutrient cycle, play a central role in the development of biofuels, and produce many critically important chemicals. These diverse applications of fungi require the interdisciplinary acquisition and application of fundamental fungal biology. This project will support the convergence and exchange of new findings amongst an interdisciplinary group of scientists dedicated to the study of fungi. \n\nThe intellectual merit of the project is rooted in the meeting's highly interdisciplinary and interactive format. The meeting will feature topics that integrate multiple time and space scales for different questions in fungal biology to promote interactions amongst researchers with diverse perspectives within the community. There is a specific emphasis on integrating mathematical modeling and biophysics as a new addition to this meeting and an entire session is dedicated to the interface of fungal biology with the physical sciences. The meeting enables cross-fertilization of ideas, from cell biology to evolution, that occurs in and outside of the sessions and especially between junior and senior scientists. Young investigators emphasize from previous meetings how interactive the conference is and how responsive it is to the presentation of their work.\n\nThis conference has broad impacts on training and is dedicated to extending the research community by emphasizing women and members of underrepresented groups in inviting speakers. The current invited speakers are approximately 50% women, including several Latinas. The small size of the meeting and the emphasis on discussion (40% of meeting time is dedicated to discussions) encourages active participation. Poster sessions are featured without competing events to focus attention on the most junior scientists, who often have the newest data. The GRC on Cell and Molecular Fungal Biology also is dedicated to research that applies basic knowledge to socially important questions involving filamentous fungi, particularly mutualisms with plants (mycorrhizae), parasitism with plants (plant pathology) and animals (animal pathology), and industrial mycology (enzyme production). The interactions among researchers focused on both basic and socially important research speeds research aimed at solving societal problems caused by or that can be improved by fungi.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6400", "attributes": { "award_id": "3U24AA022002-08S1", "title": "Southern HIV and Alcohol Research Consortium Administrative and Research Support Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21528, "first_name": "Deidra", "last_name": "Roach", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2012-09-25", "end_date": "2023-03-31", "award_amount": 152332, "principal_investigator": { "id": 21529, "first_name": "Robert L", "last_name": "Cook", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "It is not clear whether the coronavirus (COVID-19) pandemic has differentially affected HIV outcomes or drinking behavior among rural or ethnic minority populations. Understanding how COVID-19 changes HIV care and alcohol use could strengthen future HIV and alcohol care delivery to increase the resilience of these programs. Access to health research is also adversely affected by COVID-19. This shift to telehealth has potential to help clinicians and researchers connect with hard-to-reach populations. However, we need to understand feasibility and acceptability of telehealth by persons living with HIV (PLWH) if we are to extend research and improve delivery of alcohol interventions and HIV care in the future. This request is supplementary to U24AA022002, providing supportive infrastructure to the Southern HIV Alcohol Research Consortium (SHARC), including the FL Cohort. The objective of the FL Cohort is to better understand barriers and facilitators to viral suppression, focusing on alcohol use. However, the planned FL Cohort will not be able to distinguish if changes in alcohol use or HIV care are due to COVID-19, and will not have sufficient persons from rural or Haitian communities to assess differential effects in these underserved populations. This supplement will help determine how COVID-related social isolation and COVID disease have influenced the HIV care continuum, alcohol use and treatment, and acceptance of telehealth, stated interests in NOT-AA-20- 011 and high priority HIV research areas. The aims of this supplement are to: 1) Determine the impacts of COVID disease and related changes in psychosocial factors (e.g., loneliness, social support, economic insecurity, domestic violence) on alcohol use and HIV-related care and health outcomes (ART adherence, care engagement, and viral suppression) as assessed before and during social distancing measures; 2) Extend FL Cohort recruitment into rural areas and the Haitian community, and compare the psychosocial effects, changes in drinking, and HIV-related outcomes in rural vs. urban settings and within the Haitian community. 3) Assess the feasibility, acceptability, and interest in remote enrollment and data collection for research, and delivery of alcohol interventions and HIV clinical care among patients and providers, and compare optimal strategies across socio-demographic groups (e.g., age cohort, rural vs. urban, ethnic groups). We will accomplish these aims by adding an additional COVID-related questionnaire to the existing measures in the parent FL Cohort study, recruiting and additional 150 persons from rural areas and the Haitian community who will complete a single, “light” version of the study, and conducting qualitative interviews from PLWH and healthcare personnel to better understand how we can learn from the crisis to adapt new interventions. The study will have impact by directly informing strategies related to implementation of alcohol and HIV interventions, by expanding our knowledge related to the impact of a new infectious disease pandemic on drinking and HIV outcomes, and by enhancing the overall representativeness of our cohort sample.", "keywords": [ "AIDS/HIV problem", "Adherence", "Affect", "Age", "Alcohol consumption", "Alcohols", "Americas", "Area", "COVID-19", "COVID-19 pandemic", "Caring", "Clinical", "Cohort Studies", "Communicable Diseases", "Communities", "Continuity of Patient Care", "Coronavirus", "County", "Data", "Data Collection", "Data Reporting", "Disease", "Domestic Violence", "Economics", "Elderly", "Enrollment", "Epidemic", "Ethnic group", "Event", "Florida", "Funding", "Future", "HIV", "Haitian", "Health", "Health Personnel", "Healthcare", "Incidence", "Infrastructure", "Intervention", "Interview", "Knowledge", "Learning", "Left", "Light", "Loneliness", "Measures", "Medical", "Outcome", "Parents", "Participant", "Patient Self-Report", "Patients", "Persons", "Population", "Populations at Risk", "Positioning Attribute", "Prevalence", "Provider", "Psychosocial Factor", "Questionnaires", "Reporting", "Research", "Research Activity", "Research Personnel", "Research Support", "Resources", "Rural", "Rural Minority", "Sampling", "Shock", "Social Distance", "Social isolation", "Social support", "State Interests", "System", "Telemedicine", "Treatment/Psychosocial Effects", "Underserved Population", "Viral", "Visit", "Vulnerable Populations", "Work", "alcohol abuse therapy", "alcohol intervention", "alcohol misuse", "alcohol research", "care delivery", "care outcomes", "clinical care", "cohort", "comorbidity", "coronavirus disease", "drinking", "drinking behavior", "ethnic minority population", "experience", "improved", "interest", "member", "novel coronavirus", "pandemic disease", "programs", "recruit", "resilience", "rural area", "rural setting", "rural underserved", "sociodemographic group", "surveillance data", "telehealth", "treatment program", "urban setting" ], "approved": true } }, { "type": "Grant", "id": "5888", "attributes": { "award_id": "3R01GM124280-04S1", "title": "Modeling ongoing SARS-CoV2 vaccination strategies in light of emerging data on immunity and viral evolution", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 20149, "first_name": "Han", "last_name": "Nguyen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-06-01", "end_date": "2023-05-31", "award_amount": 173135, "principal_investigator": { "id": 20150, "first_name": "Benjamin A", "last_name": "Lopman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "While SARS-CoV-2, the pathogen causing COVID-19, continues to spread, the rapid development and deployment of effective vaccines provide a means by which we can reduce its future impact. Initial vaccines have shown to be highly effective, however, the current emergence of new SARS-CoV-2 variants, together with indications that of waning immunity, means that continued repeat vaccinations are likely to be required. Here, we will build upon resources we have already developed from our ongoing project aimed at modeling potential norovirus vaccines and our previous work aimed at modeling the impact of vaccination for SARS-CoV-2 Our team has made contributions and investigated the relative population impacts of SARS-CoV-2 vaccines with different mechanisms of action; characterized patterns of virus evolution that have the potential to impact vaccine efficacy and escape; and, examined initial strategies for vaccine deployment with the aim of relaxing social distancing guidelines. We will leverage these data and modeling tools and build on this work to assess more fully the patterns of immune waning and virus evolution. We will then use these data and results and combine them with our existing SARS-CoV-2 vaccine simulation model to inform the building and the calibration of an extended model. This extended model will account for waning immunity to SARS-CoV-2 and its viral evolution. Our model will inform rapidly emerging scientific questions around continued SARS-CoV-2 vaccination and re-vaccination strategies, including both boosting and vaccine reformulation.", "keywords": [ "2019-nCoV", "Antibodies", "COVID-19", "COVID-19 vaccination", "COVID-19 vaccine", "Calibration", "Collection", "Computer Simulation", "Data", "Development", "Evolution", "Future", "Guidelines", "Immune", "Immunity", "Incidence", "Infection", "Light", "Modeling", "Norovirus", "Pattern", "Population", "Public Health", "Publications", "Recommendation", "Resources", "Role", "SARS-CoV-2 immunity", "SARS-CoV-2 infection", "SARS-CoV-2 variant", "Serology", "Social Distance", "Statistical Models", "Vaccination", "Vaccines", "Viral", "Virus", "Work", "models and simulation", "pathogen", "tool", "vaccination strategy", "vaccine distribution", "vaccine efficacy", "vaccine-induced immunity" ], "approved": true } }, { "type": "Grant", "id": "4352", "attributes": { "award_id": "1458514", "title": "Geoscience Scholarships to Improve Recruitment and Retention of Academically Talented Students", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "S-STEM-Schlr Sci Tech Eng&Math" ], "program_reference_codes": [], "program_officials": [ { "id": 14805, "first_name": "Keith", "last_name": "Sverdrup", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2015-04-01", "end_date": "2021-03-31", "award_amount": 639136, "principal_investigator": { "id": 14809, "first_name": "Amy", "last_name": "Sheldon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1269, "ror": "", "name": "SUNY College at Geneseo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 14806, "first_name": "Dori J", "last_name": "Farthing", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 14807, "first_name": "Scott D", "last_name": "Giorgis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 14808, "first_name": "Nicholas H", "last_name": "Warner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1269, "ror": "", "name": "SUNY College at Geneseo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This project at SUNY Geneseo will address the national need for more and better trained geoscientists by increasing recruitment, retention to graduation, and preparation for and placement in careers or geosciences graduate programs and by combining scholarships and academic and career services. Through many student support and enrichment activities, this project will enhance interactions between SUNY Geneseo and academic institutions including SUNY Buffalo and SUNY Binghamton where many new geosciences graduates from the college pursue M.S. or Ph.D. degrees. In addition, connections to regional geosciences industries, including the American Rock Salt Company and Stell Environmental Enterprises, as well as government and academic research programs such as NASA, DOE, and a variety of National Laboratory and Research Experience for Undergraduates programs, will be strengthened through the development of opportunities for student research and internships. Together, these improvements will increase the number and quality of research opportunities for undergraduate geosciences students, increase opportunities for students to participate and present at professional and scholarly conferences, and address the national need to increase the number of geosciences students to fill jobs in oil and gas, environmental service, and mining industries. \n\nThe project will target students majoring in geology, geochemistry, and geophysics at SUNY Geneseo and is designed to meet three objectives: (1) increase recruitment and enrollment of academically talented students with financial need by at least 20%, (2) enhance retention and graduation within four years by at least 10%, and (3) increase placement in a geosciences or related science, technology, engineering, or mathematics (STEM) career or graduate program by 13%. The project leadership will work with the Office of Admissions and twenty alumni who are geoscience teachers at high schools in western New York to recruit academically talented scholars with financial need to the program. Cohorts of scholars will be brought together by (a) taking the same classes, (b) engaging in supplemental instruction programs, (c) participating in field trips, (d) interacting with graduate students and alumni, and (v) engaging in research and/or internships. The program goals will be accomplished through two primary components: (i) enhanced student support programs, and (ii) experiential learning opportunities. Career placement-related program components will be supplemented with support from the Office of Career Development. The scholarship program will allow SUNY Geneseo to implement and assess support services for geosciences students, including Supplemental Instruction (SI), Workshops with Graduate Students, a Geology Alumni-Student Program, field trips, research experiences, and internships. SI is a proven method to increase retention and graduation rates in many STEM disciplines; however, the effectiveness of SI has not been tested in the geosciences. This program will fill that void and provide insight into best practices and effective measures for promoting retention, graduation, and placement in the geosciences.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 2, "pages": 1392, "count": 13920 } } }