Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=2&sort=program_officials
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_officials", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=program_officials", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=program_officials", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_officials" }, "data": [ { "type": "Grant", "id": "4732", "attributes": { "award_id": "1247685", "title": "2013 CSHL Computational Cell Biology Conference", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "MATHEMATICAL BIOLOGY" ], "program_reference_codes": [], "program_officials": [], "start_date": "2013-04-15", "end_date": "2014-03-31", "award_amount": 14660, "principal_investigator": { "id": 16398, "first_name": "David", "last_name": "Stewart", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 992, "ror": "https://ror.org/02qz8b764", "name": "Cold Spring Harbor Laboratory", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 16397, "first_name": "Charla", "last_name": "Lambert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 992, "ror": "https://ror.org/02qz8b764", "name": "Cold Spring Harbor Laboratory", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This award supports the biennial conference on Computational Cell Biology: The Interplay between Models and Data, which takes place March 19-22, 2013, at Cold Spring Harbor Laboratory (CSHL). This meeting brings together a diverse group of scientists who study the molecular, structural, and functional aspects of cellular processes by using computer simulations and mathematical models. The interdisciplinary field computational cell biology is focused on the simulation of molecular machinery that drives the physiological behavior of living cells. To build useful quantitative models of these processes, computational scientists must work closely with experimental cell biologists; in this partnership, experimentalists collect data about cellular processes and how they change over time, while mathematicians use the information to build and improve upon computer models that accurately reflect the biology. The CSHL conference advances knowledge in cell biology by providing a forum where scientists who study all aspects of dynamic cellular processes, from data generation and analysis to the development and validation of quantitative models, can interact with each other and exchange ideas, information, and approaches. The conference includes sessions on signal processing, noise, cell mechanics, development, synthetic biology, imaging, evolution, and organizing principles of biological systems. The 2013 meeting builds on the successes of prior CSHL meetings to assemble an international gathering of scientists, discuss new developments in the field, and catalyze innovative research collaborations.\n\nThe discipline of computational cell biology seeks to develop mathematical models of living systems, such as molecular interactions during cell division in both healthy cells and cancer. The goals for such models are twofold: 1) predict outcomes from dynamical systems in the cell, thereby allowing scientists to 2) explain how cellular processes go awry in disease. To build successful models, mathematicians and computer scientists must work closely with experimental cell biologists. In this partnership, experimentalists collect quantitative information about cellular processes and how they change over time, while mathematicians use the information to build and improve upon computer models that accurately reflect the biology. The Cold Spring Harbor Laboratory conference on Computational Cell Biology: The Interplay between Models and Data advances knowledge in the field by bringing together scientists with expertise in both experimental and computational techniques, thus catalyzing scientific interactions that will ultimately accelerate the pace of discovery.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "3657", "attributes": { "award_id": "1731202", "title": "The 9th USA-China Chemical Engineering Conference, Beijing, China, October 15-19, 2017", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Proc Sys, Reac Eng & Mol Therm" ], "program_reference_codes": [], "program_officials": [], "start_date": "2017-04-15", "end_date": "2018-03-31", "award_amount": 35000, "principal_investigator": { "id": 11914, "first_name": "Ralph", "last_name": "Yang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 169, "ror": "", "name": "Regents of the University of Michigan - Ann Arbor", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 11913, "first_name": "Norman N", "last_name": "Li", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 169, "ror": "", "name": "Regents of the University of Michigan - Ann Arbor", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "This grant is to provide travel support for US-based researchers to attend The 9th Sino-USA Joint Conference of Chemical Engineering (SUCE 2017), to be held in Beijing, China, on October 15 - 19, 2017. The theme of the conference is Green Chemical Engineering and a special emphasis will be placed on Chemical Engineering yielding environmental benefits. The organizing committee, which consists of distinguished researchers with a broad range of skills in chemical engineering, will provide for a vibrant and diverse atmosphere that will foster exchange of ideas on research and education. It is anticipated that approximately 35 US-based researchers will receive partial travel support to attend this conference.\n\nGlobal challenges related to depletion of nonrenewable energy resources, climate change, environmental pollution, and population growth are creating a need for the development of green and sustainable manufacturing technologies. The three-and-half-day technical conference will feature invited plenary and keynote lectures, oral presentations, two plenary discussion panels, one forum and a poster session. The conference will emphasize not only the role of chemical engineers in the development of sustainable chemical and energy processes, but will also explore the frontiers of Chemical Engineering research and the fundamental principles that are needed to tackle these challenges. The US-based conference participants supported by this grant will have the opportunity to network with leading researchers from China and exchange ideas about the current status and future directions in research and education. They will benefit from state-of-the-art reviews and presentations by leading experts and by debating controversial points with their peers. The meeting will also provide an opportunity for interaction and cooperation among industrial and academic researchers. The organizers plan to give special consideration to young or junior faculty members from U.S. Universities. Female and under-represented minorities will also receive special consideration. The conference will address global challenges with potentially significant benefits to society.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11529", "attributes": { "award_id": "5I01RX003622-02", "title": "Exercise-based Program for Rehabilitation of Veterans with Severe Mental Illness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-06-01", "end_date": "2026-05-31", "award_amount": null, "principal_investigator": { "id": 23883, "first_name": "GRETCHEN L", "last_name": "HAAS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23884, "first_name": "Vishwajit Laxmikant", "last_name": "Nimgaonkar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "This is a Hybrid 1, effectiveness-implementation study of yoga-based exercise (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI), defined here as schizophrenia (SZ), schizoaffective disorder (SZA) and bipolar I disorder (BP1). SMIs are common, severe and devastating conditions that cause enormous disability world-wide. Many features of SMI can be treated effectively, yet the long-term outcome has not improved much over the past century. The lack of improvement may be due to ineffective treatment of functional deficits in SMI patients, particularly in terms of community functioning, defined here as social, leisure, employment, and life skills functioning in the community. Complementary and Integrative Medicine (CIM) therapies that improve community functions are thus of great interest for treating Veterans with SMI and thereby target an area of high priority for the VA. Prior studies have shown short-term benefits of YE for improving cognitive deficits and community functions among persons with SMI. While the published studies are encouraging, the longer-term benefits of YE are untested, particularly for community functioning. The profile of Veterans with SMI who will accept and adopt YE is also unknown. We have conducted pilot studies and a randomized controlled trial (RCT) for individuals with SMI in India using short-term, simplified YE combined with medications. Recently, we also concluded RELIEVE, a RCT of adjunctive YE for Veterans with post-traumatic stress disorder (PTSD) in the USA (VA RR&D Merit award, PI: L Davis, PsyD). We found encouraging improvements from all our studies, but our Indian and US YE protocols are impractical for Veterans with SMI. For example, some postures may be difficult for older Veterans with amotivation and/or physical disabilities. Therefore, in Aim 1, we will design and evaluate adaptations of the Indian and US YE protocols in a non-religious context (mindfulness, stretching, toning and breathing exercises). We will consult our Indian and US colleagues, our Veterans with SMI and their VA therapists to adapt the protocol for our SMI population. We will also adapt our control condition, the Wellness Lifestyle Program (WLP), from our recently completed RELIEVE study. In Aim 2, we will conduct a 2-armed RCT in which consenting Veterans with SMI will be randomly assigned to one of 2 arms: YE and treatment as usual (TAU, any prescribed treatment) or WLP+ TAU. Unlike prior short-term YE RCTs, the two arms will continue 12 months, including an initial 12-week training period consisting of two supervised sessions per week, followed by a 12-week training period consisting of one supervised session per week, and monthly refresher training sessions offered for the remaining 6 months. We will conform to all COVID-19 related requirements for YE and WLP. Our Hybrid 1 trial will compare the efficacy of YE versus WLP. Primary outcomes are self-report and performance-based measures of community functioning; secondary outcomes are cognition and physical fitness measures. Our goals in Aim 3 are to understand demographic/clinical features of Veterans with SMI who are more likely to accept and adopt YE to enable long-term rehabilitation, by analysis of the RCT data (Aim 3A). We will also conduct qualitative interviews with Veterans who have SMI and participated in the YE intervention arm, referring clinicians, and the Yoga instructor to identify barriers and facilitators for implementation (Aim 3B). The project thus aims to advance our long-term goals for improving the quality of life for Veterans with SMI and to provide evidence to guide home- based and over the longer term, community-based YE practice, consistent with the Mission Act and the VA Strategic Plan. Our experience in conducting a variety of SMI research for over 25 years offers strong support for successful completion of the proposal.", "keywords": [ "Adopted", "Adoption", "Affect", "Area", "Award", "Bipolar I", "Breathing Exercises", "COVID-19", "Characteristics", "Clinic", "Clinical", "Cognition", "Cognitive deficits", "Communities", "Community Integration", "Complementary Medicine", "Consent", "Consolidated Framework for Implementation Research", "Consult", "Data", "Disease", "Elements", "Employment", "Ensure", "Exercise", "Family", "Frequencies", "Goals", "Health", "Health Personnel", "Healthcare", "Home", "Hybrids", "Impaired cognition", "Impairment", "India", "Individual", "Integrative Medicine", "Intervention", "Interview", "Leisures", "Life", "Life Style", "Measures", "Mental Health", "Mission", "Muscle Contraction", "Outcome", "Participant", "Patient Self-Report", "Patients", "Pattern", "Persons", "Pharmaceutical Preparations", "Physical Fitness", "Pilot Projects", "Population", "Post-Traumatic Stress Disorders", "Posture", "Prevalence", "Protocols documentation", "Publishing", "Quality of life", "Randomized", "Randomized Controlled Trials", "Recording of previous events", "Refractory", "Regulation", "Rehabilitation therapy", "Relaxation", "Research", "Research Design", "Role", "Rural Community", "Safety", "Schedule", "Schizoaffective Disorders", "Schizophrenia", "Services", "Social Functioning", "Socialization", "Strategic Planning", "Stretching", "Substance Use Disorder", "Suicide prevention", "Symptoms", "Techniques", "Testing", "Time", "Training", "Veterans", "Yoga", "alcohol use disorder", "arm", "cognitive benefits", "comorbidity", "comparative efficacy", "cost", "design", "disability", "effectiveness/implementation study", "efficacy study", "exercise intervention", "exercise program", "exercise training", "experience", "future implementation", "implementation efforts", "implementation facilitators", "improved", "ineffective therapies", "instructor", "interest", "long-term rehabilitation", "mindfulness", "performance based measurement", "physically handicapped", "primary outcome", "programs", "secondary outcome", "severe mental illness", "skills", "social", "study characteristics", "tool", "treatment arm", "treatment as usual", "uptake", "virtual", "whole health" ], "approved": true } }, { "type": "Grant", "id": "10675", "attributes": { "award_id": "1U01IP001191-01", "title": "Evaluating influenza, SARS-CoV-2, and other respiratory virus vaccine effectiveness in prevention of acute illness in Washington state 2022-2027", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-09-30", "end_date": "2027-09-29", "award_amount": 2000000, "principal_investigator": { "id": 26733, "first_name": "Karen J", "last_name": "Wernli", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1955, "ror": "", "name": "KAISER FOUNDATION HEALTH PLAN OF WASHINGTON", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "As one of the current US Influenza Vaccine Effectiveness (US Flu VE) Network sites, we propose continuing our studies of vaccine effectiveness (VE) for seasonal influenza, COVID-19, and other respiratory viruses to prevent acute respiratory illness (ARI) in Washington state from 2022 to 2027 (Component A). Since March 2020, the COVID-19 pandemic has resulted in >80 million infections and ~1 million US deaths. Until the pandemic, the dominant respiratory virus impacting public health seasonally was influenza. In the US, up to 5% of the population sought outpatient care during a severe epidemic, and a typical epidemic caused tens of thousands of deaths and hundreds of thousands of hospitalizations. The COVID-19 pandemic catalyzed rapid adoption of telehealth care, in particular for patients with mild to moderate ARI, shifting patients from ambulatory visits to minimize healthcare exposure to COVID-19. Currently, influenza and COVID-19 vaccinations are the best available tools for reducing the respiratory virus burden and maintaining population immunity. Vaccination programs represent a substantial public health investment. Given the magnitude of this investment and the dynamic impact of respiratory viruses on public health, policymakers need accurate, timely, and relevant data representing real-world VE to monitor the impact on respiratory illness burden in US populations. The next 5 years of surveillance of respiratory illness in US populations will be critical in accounting for changes in respiratory virus burden. The US Flu VE Network has the capacity, infrastructure, research methods, and specimen collection experience to monitor any respiratory virus within US health care. From 2022-2027, we propose to enroll ~6000 KPWA infants, children, and adults including older adults in urgent care clinics, collect respiratory and blood specimens, complete enrollment and post-enrollment questionnaires, collaborate with laboratory services to type and genetically sequence specimens, collate and curate EHR data, collaborate across the Network with Component A sites, share data with Network Coordination Center (Component B), share specimens with site leading Component E, participate in Network research activities including dissemination, and develop new methods for estimation and inference in VE. Our specific aims to meet the goals of the US Flu VE Network are: Aim 1. Establish a platform to estimate VE of seasonal influenza and COVID-19 vaccines against respiratory viral illnesses in preventing laboratory- confirmed illness among children and adults with mild or moderate illness seeking care in ambulatory settings (Objective 1); Aim 2. Establish a protocol to obtain influenza and SARS-CoV-2 viral sequences from specimens collected among infected participants in the proposed outpatient network (Objective 2); Aim 3. Describe capacity and diagnostic test methods available in KPWA and methods to obtain COVID-19 vaccination data outside influenza season (Objective 3). Aim 4. Improve precision of the test-negative design by incorporate two-phase sampling methodology (methods aim).", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4663", "attributes": { "award_id": "1451136", "title": "Workshop on Mathematical Biology and Nonlinear Analysis", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "MATHEMATICAL BIOLOGY" ], "program_reference_codes": [], "program_officials": [], "start_date": "2014-09-01", "end_date": "2015-08-31", "award_amount": 10800, "principal_investigator": { "id": 16141, "first_name": "George", "last_name": "Cosner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 647, "ror": "https://ror.org/02dgjyy92", "name": "University of Miami", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 16138, "first_name": "Yuan", "last_name": "Lou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 16139, "first_name": "Wenxian", "last_name": "Shen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 16140, "first_name": "Shigui", "last_name": "Ruan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 647, "ror": "https://ror.org/02dgjyy92", "name": "University of Miami", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "This is a proposal to provide travel support for ten U.S. based junior researchers to attend the Workshop on Mathematical Biology and Nonlinear Analysis, which will be held at the Coral Gables campus of the University of Miami, December 19-21, 2014. \n\nThe Workshop will focus on the applications of mathematical methods for studying nonlinear equations that model biological processes, especially in ecology, epidemiology, and evolutionary theory. The conference will provide opportunities for junior researchers to interact with leading researchers in these areas. The workshop will feature plenary lectures by leading scientists and will hold special topic sessions where researchers will present their ideas and results. One of the aims of the conference is to broaden the education and stimulate the research of junior researchers and those from underrepresented groups. NSF funding is vital in achieving this goal.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "3294", "attributes": { "award_id": "1840245", "title": "Florida A&M Geosciences Education: Workshop on Improving Undergraduate Geosciences Teacher Preparation Using Micro Spiral Methodology", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Hist Black Colleges and Univ" ], "program_reference_codes": [], "program_officials": [], "start_date": "2018-08-01", "end_date": "2019-09-30", "award_amount": 49997, "principal_investigator": { "id": 10419, "first_name": "Edith", "last_name": "Davis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 533, "ror": "https://ror.org/00c4wc133", "name": "Florida Agricultural and Mechanical University", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 533, "ror": "https://ror.org/00c4wc133", "name": "Florida Agricultural and Mechanical University", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The Historically Black Colleges and Universities - Undergraduate Program (HBCU-UP) supports conferences and workshops that seek to increase the research and education capacity of science, technology, engineering, and mathematics (STEM) students and faculty at HBCUs. Florida Agricultural and Mechanical University will hold a workshop on October 18-19, 2018 to improve the preparation of pre-service earth science teachers at HBCUs. About fifty pre-service teachers and faculty will attend.\n\nThe workshop provides hands-on activities and reflection sessions to equip college faculty in using the micro-spiral approach in their geosciences courses at the undergraduate level. The objectives are to: transfer geosciences concepts, knowledge and skills to pre-service and in-service teachers; support pre-service teacher education programs; and support in-service teachers in their quest to educate future geoscientists. The workshop will focus on training in the communication of culturally and regionally relevant geoscience knowledge, and on providing a geosciences tool capable to give support to pre-service teachers in Earth Science Standards content and National Science Teachers Association Standards for the Science Teacher Preparation Certification process.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "3973", "attributes": { "award_id": "1725413", "title": "MRI: Acquisition of a Multipoint Laser Vibrometer for Studying Multiscale and Nonstationary Dynamics of Materials and Complex Structures", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Major Research Instrumentation" ], "program_reference_codes": [], "program_officials": [], "start_date": "2017-10-01", "end_date": "2020-09-30", "award_amount": 470250, "principal_investigator": { "id": 13200, "first_name": "Melih", "last_name": "Eriten", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 263, "ror": "", "name": "University of Wisconsin-Madison", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 13199, "first_name": "Matthew S", "last_name": "Allen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 263, "ror": "", "name": "University of Wisconsin-Madison", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "This Major Research Instrumentation award supports the acquisition of a Multipoint Laser Vibrometer (MPV800) system to enable potentially transformative research in civil and mechanical engineering, materials, and biomedical engineering. The MPV800 system tracks transient and random vibrations and structural deformations, allowing researchers to monitor the dynamic response of materials, components and systems with challenging geometries and soft materials, such as biological tissues. The MPV 800 also monitors nonlinear vibration and wave propagation. Researchers will gain an enhanced understanding of the dynamic behavior of complex systems that can lead to advances in early-diagnosis of disease, more reliable 3D printing processes and the development of novel materials and structures with enhanced resilience. The MPV800 system will also be used in laboratory projects to educate the next generation of vibration engineers and outreach events for industry and the public.\n\nThe MPV800 laser vibrometer with 5-optical units and 40 fiber heads enables noncontact and full-field vibration measurements up to 0.5 mm spatial resolution, and bandwidth ranging from several Hz to 100 kHz. This new system also uses a wavelength of 1550 nm for higher reflectance and lower noise in testing soft and hard materials, even materials with high water content such as biological tissues, swollen polymers and hydrogels. A total of 10 major users will use the system to measure the dynamic response of soft, porous, multiphasic, and hard materials with an unprecedented range and resolution in time and space. The MPV800 system will provide essential measurements to update models of sophisticated assemblies in civil and aerospace applications. It will also be used for noncontact characterization and structural health monitoring of 3D printed parts and tissue scaffolds. Analysis of wave propagation in cartilage and tendons will reveal new insights on the high loading-rate response of those tissues and the tissue behavior that leads to osteoarthritis.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10725", "attributes": { "award_id": "1IK2RX003790-01A2", "title": "Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-01", "end_date": "2027-10-31", "award_amount": null, "principal_investigator": { "id": 26774, "first_name": "John Harvey", "last_name": "Kindred", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1782, "ror": "", "name": "RALPH H JOHNSON VA MEDICAL CENTER", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The long-term goal of this proposed career development award (CDA-2) is to accelerate my training and development so that I can establish an independent line of research unraveling the causes and consequences of fatigue and to develop effective evidence-based therapies for fatigue in Veterans with neurological conditions. Before my collegiate studies, I served nine years on active duty in the United States Marine Corps and received an Honorable Discharge upon the expiration of my service contract. I completed my Ph.D. in Human Bioenergetics at Colorado State University in 2017. Upon graduation, I began a post-doctoral position at the Medical University of South Carolina working with Dr. Mark G. Bowden, PT, Ph.D. Shortly after starting my post- doc position, I acquired a WOC appointment at the Ralph H. Johnson VA Medical Center and was awarded a VA Rehabilitation Research and Development Career Development Award – 1 that began in Oct 2019. Since the beginning of my research journey, I have published 22 peer-reviewed manuscripts, 12 as the first author. My most recent publications have centered on measuring the neurophysiological state of the nervous system and relating that state to post-stroke disability. These most recent manuscripts are based on data collected at the laboratories at Ralph H. Johnson before my arrival and the co-authors include several of the members of this proposal’s mentorship team. Upon completing my CDA-1 (end date Sep 30, 2021), I have focused my attention on the neurophysiological biomarkers of post-stroke fatigue. This CDA-2 proposal will provide me with the opportunity to learn new neurophysiological assessment methods and advance my knowledge and ability to apply neuromodulatory treatments. These skills will provide me the foundation to build an independent VA- backed research program focusing on reducing the impact of fatigue in Veterans with an array of neurological conditions. The assembled mentorship team is composed of experts in post-stroke rehabilitation, neuromodulation, neuroimaging, and clinical assessment. Up to 92% of people post-stroke experience fatigue. Fatigue negatively affects physical and mental performance leading to a lower quality of life. Fatigue is also present in many other neurological populations within the Veteran community, such as traumatic brain injury, multiple sclerosis, and the newly coined phenomenon of Long-COVID. Advances in the knowledge and understanding of post-stroke fatigue are likely to lead to advances in other clinical populations within the Veteran community. The first aim is to test the effects of a well-established neuromodulatory therapy, repetitive transcranial magnetic stimulation (rTMS), on reducing the severity of post-stroke fatigue. This aim is predicated on theoretical principles obtained from the study of other neuro-psychiatric/-cognitive disorders and therapeutic attempts to reduce fatigue in other neurological illnesses. Participating Veterans will receive high-frequency rTMS to the frontal lobe, either the left prefrontal dorsolateral cortex or bilaterally to the motor cortices. These locations have been implicated in fatigue in other neurological conditions. I expect to show rTMS can be used to reduce post-stroke fatigue severity. However, the effectiveness and location of treatment may partially be dependent on individual characteristics. The second aim of the study is based on the skills and knowledge developed in the CDA-1, I plan on identifying additional neurophysiological biomarkers of fatigue. In this project, I will assess glutamatergic activity/signaling of the upper and lower extremity sensorimotor network of Veterans with and without post-stroke fatigue. I expect to show that the fatigued group will show glutamatergic dysfunction, measured by greater asymmetries in intracortical facilitation and the facilitatory response to paired associative stimulation, compared to the non-fatigued group. Identification of glutamate and related metabolites as a pathophysiological contributor to post-stroke fatigue may help in the development of new therapeutic approaches for post-stroke fatigue and fatigue in other neurological conditions.", "keywords": [ "Affect", "American Heart Association", "Anxiety", "Appointment", "Attention", "Award", "Back", "Behavior", "Bilateral", "Bioenergetics", "Biological Markers", "Caregivers", "Characteristics", "Chronic Fatigue Syndrome", "Clinical", "Clinical assessments", "Cognition Disorders", "Coin", "Colorado", "Communities", "Contract Services", "Data", "Development", "Doctor of Philosophy", "Effectiveness", "Environment", "Evidence based treatment", "FDA approved", "Fatigue", "Foundations", "Frequencies", "Functional disorder", "Glutamates", "Goals", "Human", "Individual", "Intervention", "K-Series Research Career Programs", "Knowledge", "Laboratories", "Lead", "Learning", "Left", "Lesion", "Location", "Long COVID", "Lower Extremity", "Magnetic Resonance Spectroscopy", "Manuscripts", "Measures", "Medical", "Medical center", "Mental Depression", "Mental disorders", "Mentorship", "Methods", "Motor", "Motor Cortex", "Multiple Sclerosis", "Nature", "Nervous System Physiology", "Nervous system structure", "Neuraxis", "Neurocognitive", "Neurologic", "Peer Review", "Performance", "Persons", "Pharmacology", "Physical Function", "Physical activity", "Physiologic pulse", "Pilot Projects", "Play", "Population", "Positioning Attribute", "Post-Traumatic Stress Disorders", "Postdoctoral Fellow", "Prefrontal Cortex", "Prevalence", "Psyche structure", "Publications", "Publishing", "Quality of life", "Recording of previous events", "Rehabilitation therapy", "Research", "Research Personnel", "Role", "Scientist", "Services", "Severities", "Signal Transduction", "South Carolina", "Stroke", "Structure", "System", "Testing", "Therapeutic", "Training", "Transcranial magnetic stimulation", "Traumatic Brain Injury", "United States", "Universities", "Update", "Upper Extremity", "Veterans", "Veterans Health Administration", "Work", "active duty", "base", "career", "career development", "chronic stroke", "cognitive function", "college", "cost", "disability", "effective intervention", "effective therapy", "efficacy testing", "evidence base", "experience", "expiration", "frontal lobe", "improved", "insight", "member", "military veteran", "multidisciplinary", "negative affect", "nervous system disorder", "neural circuit", "neuroimaging", "neurophysiology", "neuropsychiatry", "neuroregulation", "noninvasive brain stimulation", "novel", "novel therapeutic intervention", "post stroke", "programs", "psychologic", "rehabilitation re" ], "approved": true } }, { "type": "Grant", "id": "10791", "attributes": { "award_id": "1I01HX002941-01A2", "title": "A web-based program to improve chronic illness self-management by engaging patients and informal caregivers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-10-01", "end_date": "2026-09-30", "award_amount": null, "principal_investigator": { "id": 26867, "first_name": "Ranak", "last_name": "Trivedi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1497, "ror": "", "name": "VETERANS ADMIN PALO ALTO HEALTH CARE SYS", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Background: For the 80% of older Americans who have at least one chronic condition, sharing self- management responsibilities with caregivers (relatives or friends) predicts longevity, better health, better quality of life, and fewer hospitalizations. Caregivers often support patients in their self-management efforts. This can bring patients and caregivers closer but can also generate stress for both that can interfere with self- management. Yet, self-management programs rarely support the coping needs of patient-caregiver dyads. Significance: There are more than 5 million caregivers of Veterans; 75% of older Veterans receive some caregiver support. Caregivers incur individual financial and emotional costs even as they provide unpaid care. Having an effective self-management strategy that addresses the needs of both can improve outcomes and quality of life for millions of Veterans who suffer from chronic illnesses and their caregivers. This project addresses the priorities “Long-term care and Caregiving,” “Virtual Care/Telehealth,” and “Access to Care” and is consistent with the legislative goals of the MISSION Act. Innovation and Impact: This highly innovative proposal uses the novel concept that strengthening the interpersonal relationships between Veterans and caregivers can improve the self-management of chronic conditions. It challenges current clinical paradigms by addressing the collective stress coping needs of dyads. It is methodologically innovative because unlike many behavioral intervention trials, it assesses barriers and facilitators to plan for future implementation. Our focus on technology-enabled tools is timely given how COVID19 has transformed care delivery. This project takes advantage of the unique capabilities of the VA health system to explore questions including robust caregiver support and virtual care programs. Specific Aims: With investments from VA HSR&D, we have developed and successfully pilot tested a new theoretically-derived technology called Web-based Self-care Using Collaborative Coping EnhancEment in Diseases (web-SUCCEED). We propose to conduct a randomized clinical trial comparing web-SUCCEED to an enhanced usual care (EUC) control. We will conduct a formative evaluation guided by the Consolidated Framework of Implementation Research (CFIR) to accelerate future implementation. 1. Assess whether web-SUCCEED improves Veteran outcomes of self-management compared to EUC, 4 weeks and 6 months following randomization. 2a. Assess whether web-SUCCEED improves patient stress and quality of life. 2b. Assess whether web-SUCCEED improves caregiver stress, quality of life and caregiver burden. 2c. Examine communication, dyadic coping, mutuality, and relationship quality as mediators of primary and secondary outcomes (Aims 1, 2a, 2b). 3. Guided by CFIR, conduct a formative evaluation involving key stakeholder interviews to understand barriers and facilitators of future implementation. Methodology: We will recruit 280 cognitively intact Veterans from VA Palo Alto Health Care System who are managing at least one common chronic condition, and their caregivers. Veteran-caregiver dyads will be randomized 1:1 to web-SUCCEED or EUC. Veteran and caregiver assessments will take place at baseline, then again at 4 weeks and 6 months. The formative evaluation will be guided by CFIR and involve semi- structured interviews with clinical staff, providers, and facility leaders in Year 4. Next Steps: Our formative evaluation will set us up for implementation studies to evaluate web-SUCCEED in a wider array of clinical settings and facilities. Existing operational partnerships will facilitate wider clinical implementation and moving research into practice. Our innovative project, strong investigative team and operational partnerships will ensure a successful study that has the potential to shift clinical paradigms.", "keywords": [ "Address", "Adult", "American", "Award", "Behavior Therapy", "Behavioral", "COVID-19", "Caregiver Burden", "Caregiver support", "Caregivers", "Caring", "Chronic", "Chronic Disease", "Chronically Ill", "Clinical", "Cognitive", "Collaborations", "Communication", "Consolidated Framework for Implementation Research", "Data", "Diabetes Mellitus", "Diagnosis", "Disease", "Distress", "Emotional", "Ensure", "Equipment and supply inventories", "Face", "Family Caregiver", "Family member", "Friends", "Funding", "Gender", "Goals", "Grant", "Health", "Health Services Accessibility", "Health system", "Healthcare Systems", "Hospitalization", "Individual", "Internet", "Interpersonal Relations", "Intervention Trial", "Interview", "Investments", "Learning", "Life Style", "Long-Term Care", "Longevity", "Maintenance", "Measures", "Mediator of activation protein", "Medication Management", "Mental Depression", "Methodology", "Myocardial Ischemia", "Online Systems", "Outcome", "Pain", "Patients", "Persons", "Pilot Projects", "Practice Management", "Primary Care Physician", "Prognosis", "Provider", "Psychologist", "Quality of life", "Randomized", "Randomized Clinical Trials", "Reporting", "Resources", "Scientist", "Self Care", "Self Management", "Services", "Stress", "Stress and Coping", "Structure", "Technology", "Telephone", "Testing", "Time", "Veterans", "Visual", "Work", "acceptability and feasibility", "arm", "behavior change", "care delivery", "caregiver stress", "caregiving", "clinical implementation", "clinical practice", "coping", "cost", "design", "effectiveness evaluation", "experience", "follow-up", "formative assessment", "future implementation", "implementation study", "improved", "improved outcome", "informal caregiver", "innovation", "member", "mobile application", "novel", "peer support", "pilot test", "positive emotional state", "primary outcome", "programs", "recruit", "research to practice", "retention rate", "rural area", "secondary outcome", "self-management program", "skills", "telehealthcare", "telephone-based", "tool", "treatment as usual", "trial comparing", "usability", "user centered design", "virtual healthcare", "web site" ], "approved": true } }, { "type": "Grant", "id": "11441", "attributes": { "award_id": "1P20GM144265-01A1", "title": "Cellular Programming in Persistent Versus Lytic Viral Infections", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2023-04-05", "end_date": "2028-03-31", "award_amount": 262439, "principal_investigator": { "id": 27503, "first_name": "Melissa", "last_name": "Maginnis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2031, "ror": "", "name": "UNIVERSITY OF MAINE ORONO", "address": "", "city": "", "state": "ME", "zip": "", "country": "United States", "approved": true }, "abstract": "CELLULAR REPROGRAMMING IN PERSISTENT VS. LYTIC VIRAL INFECTIONS PROJECT SUMMARY The long-range goal of the proposed research is to define the cellular factors that mediate JC polyomavirus (JCPyV) infection to better understand how virus-host cell interactions influence viral pathogenesis. JCPyV infects up to 80% of the population and establishes a lifelong, asymptomatic persistent infection in the kidneys of healthy individuals. However, in immunocompromised individuals JCPyV can spread to the central nervous system (CNS) and cause a lytic infection in glial cells resulting in the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). Approximately 5% of individuals with HIV develop PML, a terminal AIDS- defining illness, and individuals receiving immunomodulatory therapies for diseases including multiple sclerosis are at heightened risk for PML development. The increasing number of individuals receiving immunomodulatory therapies due to immune-mediated diseases has led to a rising number of PML cases in the past decade. Over 700 total cases of PML are due to a single drug class. PML can be fatal, especially when underlying immunosuppression is left untreated, and there are currently no approved treatments for this devastating disease. The lack of an animal model and limited cell culture models have largely restricted studies of JCPyV to a single transformed cell culture model. Recently-published studies have revealed that primary cell culture models are a better representation of disease pathogenesis in vivo, and thus we have developed innovative primary cell culture models to define cellular factors that are required for JCPyV infection. Two integrated specific aims are proposed in this research project to: 1) characterize cellular factors that mediate JCPyV entry and infection in primary cell types, and 2) elucidate cell-type dependent differences in persistent and lytic JCPyV infections. This research will enhance our understanding of how virus-host cell interactions influence disease outcomes and will serve as a platform for the development of antiviral treatments. Through this work, cellular factors required for JCPyV entry in primary cell types will be characterized through loss- and gain-of-function approaches using cell-based assays. Transcriptome profiling through RNA sequencing analysis will be used to determine how JCPyV infection alters gene expression in a cell-type dependent manner to identify pathways relevant to JCPyV pathogenesis and fatal disease outcomes. This combinatorial approach utilizes newly developed primary cell models of JCPyV infection and takes advantage of innovative high-throughput analysis of viral and cellular protein expression and RNA sequencing approaches. This research will fill key gaps in our knowledge of JCPyV biology and could elucidate novel antiviral targets or provide rationale for experimental use of on-market therapies to prevent or treat the fatal disease PML. Findings obtained from this research will also provide broader insights into the entry and signaling networks for other pathogenic viruses, like coronaviruses, and improve our understanding of dysregulation of cellular signaling in other diseases such as cancer.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Animal Model", "Astrocytes", "Biological Assay", "Biological Models", "Biology", "Brain", "Cell Communication", "Cell Culture Techniques", "Cell model", "Cells", "Central Nervous System", "Chronic", "Clathrin", "Comparative Genomic Analysis", "Coronavirus", "Cues", "Data", "Demyelinating Diseases", "Development", "Disease", "Disease Outcome", "Endocytosis", "G Protein-Coupled Receptor Signaling", "Gene Expression", "Genetic Transcription", "Goals", "Growth", "HIV", "Human", "Immune", "Immunocompromised Host", "Immunosuppression", "Individual", "Infection", "Invaded", "JC Virus", "Kidney", "Knowledge", "Left", "Lytic", "Lytic Phase", "Malignant Neoplasms", "Marketing", "Mediating", "Mitogen-Activated Protein Kinases", "Modeling", "Multiple Sclerosis", "Neuroglia", "Oligodendroglia", "Outcome", "Pathogenesis", "Pathology", "Pathway interactions", "Pharmaceutical Preparations", "Polyomavirus Infections", "Population", "Predisposition", "Prevalence", "Primary Cell Cultures", "Production", "Progressive Disease", "Progressive Multifocal Leukoencephalopathy", "Publishing", "Regulation", "Research", "Research Project Grants", "Risk", "Role", "Serotonin", "Signal Induction", "Signal Pathway", "Signal Transduction", "Testing", "Therapeutic", "Tissues", "Viral", "Viral Pathogenesis", "Virus", "Virus Diseases", "Virus Receptors", "Virus Replication", "Work", "antiviral drug development", "brain cell", "cell behavior", "cell growth regulation", "cell immortalization", "cell transformation", "cell type", "chronic infection", "combinatorial", "design", "effective therapy", "experimental study", "extracellular", "gain of function", "high throughput analysis", "high-throughput drug screening", "immunomodulatory therapies", "improved", "in vitro Model", "in vivo", "innovation", "insight", "kidney cell", "kidney infection", "novel", "pathogenic virus", "prevent", "programs", "protein expression", "receptor", "response", "serotonin receptor", "transcriptome", "transcriptome sequencing" ], "approved": true } } ], "meta": { "pagination": { "page": 2, "pages": 1424, "count": 14236 } } }