Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=2&sort=program_officials
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_officials", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=program_officials", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=program_officials", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_officials" }, "data": [ { "type": "Grant", "id": "11441", "attributes": { "award_id": "1P20GM144265-01A1", "title": "Cellular Programming in Persistent Versus Lytic Viral Infections", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2023-04-05", "end_date": "2028-03-31", "award_amount": 262439, "principal_investigator": { "id": 27503, "first_name": "Melissa", "last_name": "Maginnis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2031, "ror": "", "name": "UNIVERSITY OF MAINE ORONO", "address": "", "city": "", "state": "ME", "zip": "", "country": "United States", "approved": true }, "abstract": "CELLULAR REPROGRAMMING IN PERSISTENT VS. LYTIC VIRAL INFECTIONS PROJECT SUMMARY The long-range goal of the proposed research is to define the cellular factors that mediate JC polyomavirus (JCPyV) infection to better understand how virus-host cell interactions influence viral pathogenesis. JCPyV infects up to 80% of the population and establishes a lifelong, asymptomatic persistent infection in the kidneys of healthy individuals. However, in immunocompromised individuals JCPyV can spread to the central nervous system (CNS) and cause a lytic infection in glial cells resulting in the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). Approximately 5% of individuals with HIV develop PML, a terminal AIDS- defining illness, and individuals receiving immunomodulatory therapies for diseases including multiple sclerosis are at heightened risk for PML development. The increasing number of individuals receiving immunomodulatory therapies due to immune-mediated diseases has led to a rising number of PML cases in the past decade. Over 700 total cases of PML are due to a single drug class. PML can be fatal, especially when underlying immunosuppression is left untreated, and there are currently no approved treatments for this devastating disease. The lack of an animal model and limited cell culture models have largely restricted studies of JCPyV to a single transformed cell culture model. Recently-published studies have revealed that primary cell culture models are a better representation of disease pathogenesis in vivo, and thus we have developed innovative primary cell culture models to define cellular factors that are required for JCPyV infection. Two integrated specific aims are proposed in this research project to: 1) characterize cellular factors that mediate JCPyV entry and infection in primary cell types, and 2) elucidate cell-type dependent differences in persistent and lytic JCPyV infections. This research will enhance our understanding of how virus-host cell interactions influence disease outcomes and will serve as a platform for the development of antiviral treatments. Through this work, cellular factors required for JCPyV entry in primary cell types will be characterized through loss- and gain-of-function approaches using cell-based assays. Transcriptome profiling through RNA sequencing analysis will be used to determine how JCPyV infection alters gene expression in a cell-type dependent manner to identify pathways relevant to JCPyV pathogenesis and fatal disease outcomes. This combinatorial approach utilizes newly developed primary cell models of JCPyV infection and takes advantage of innovative high-throughput analysis of viral and cellular protein expression and RNA sequencing approaches. This research will fill key gaps in our knowledge of JCPyV biology and could elucidate novel antiviral targets or provide rationale for experimental use of on-market therapies to prevent or treat the fatal disease PML. Findings obtained from this research will also provide broader insights into the entry and signaling networks for other pathogenic viruses, like coronaviruses, and improve our understanding of dysregulation of cellular signaling in other diseases such as cancer.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Animal Model", "Astrocytes", "Biological Assay", "Biological Models", "Biology", "Brain", "Cell Communication", "Cell Culture Techniques", "Cell model", "Cells", "Central Nervous System", "Chronic", "Clathrin", "Comparative Genomic Analysis", "Coronavirus", "Cues", "Data", "Demyelinating Diseases", "Development", "Disease", "Disease Outcome", "Endocytosis", "G Protein-Coupled Receptor Signaling", "Gene Expression", "Genetic Transcription", "Goals", "Growth", "HIV", "Human", "Immune", "Immunocompromised Host", "Immunosuppression", "Individual", "Infection", "Invaded", "JC Virus", "Kidney", "Knowledge", "Left", "Lytic", "Lytic Phase", "Malignant Neoplasms", "Marketing", "Mediating", "Mitogen-Activated Protein Kinases", "Modeling", "Multiple Sclerosis", "Neuroglia", "Oligodendroglia", "Outcome", "Pathogenesis", "Pathology", "Pathway interactions", "Pharmaceutical Preparations", "Polyomavirus Infections", "Population", "Predisposition", "Prevalence", "Primary Cell Cultures", "Production", "Progressive Disease", "Progressive Multifocal Leukoencephalopathy", "Publishing", "Regulation", "Research", "Research Project Grants", "Risk", "Role", "Serotonin", "Signal Induction", "Signal Pathway", "Signal Transduction", "Testing", "Therapeutic", "Tissues", "Viral", "Viral Pathogenesis", "Virus", "Virus Diseases", "Virus Receptors", "Virus Replication", "Work", "antiviral drug development", "brain cell", "cell behavior", "cell growth regulation", "cell immortalization", "cell transformation", "cell type", "chronic infection", "combinatorial", "design", "effective therapy", "experimental study", "extracellular", "gain of function", "high throughput analysis", "high-throughput drug screening", "immunomodulatory therapies", "improved", "in vitro Model", "in vivo", "innovation", "insight", "kidney cell", "kidney infection", "novel", "pathogenic virus", "prevent", "programs", "protein expression", "receptor", "response", "serotonin receptor", "transcriptome", "transcriptome sequencing" ], "approved": true } }, { "type": "Grant", "id": "5433", "attributes": { "award_id": "NNX08AB86G", "title": "THE OUTSKIRTS OF A262 AND MKW 4 We propose two 19 arcmin offset observations of the galaxy groups A 262 and MKW 4 to measure spatially resolved densities, temperatures and iron abundances out to r-(500). These measurements arc crucial for an accurate dete", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2007-11-15", "end_date": "2009-11-14", "award_amount": 0, "principal_investigator": { "id": 18974, "first_name": "DAVID", "last_name": "BUOTE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1407, "ror": "", "name": "REGENTS OF THE UNIVERSITY OF CALIFORNIA THE (6406)", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "THE OUTSKIRTS OF A262 AND MKW 4 We propose two 19 arcmin offset observations of the galaxy groups A 262 and MKW 4 to measure spatially resolved densities, temperatures and iron abundances out to r-(500). These measurements arc crucial for an accurate dete", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10725", "attributes": { "award_id": "1IK2RX003790-01A2", "title": "Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-01", "end_date": "2027-10-31", "award_amount": null, "principal_investigator": { "id": 26774, "first_name": "John Harvey", "last_name": "Kindred", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1782, "ror": "", "name": "RALPH H JOHNSON VA MEDICAL CENTER", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The long-term goal of this proposed career development award (CDA-2) is to accelerate my training and development so that I can establish an independent line of research unraveling the causes and consequences of fatigue and to develop effective evidence-based therapies for fatigue in Veterans with neurological conditions. Before my collegiate studies, I served nine years on active duty in the United States Marine Corps and received an Honorable Discharge upon the expiration of my service contract. I completed my Ph.D. in Human Bioenergetics at Colorado State University in 2017. Upon graduation, I began a post-doctoral position at the Medical University of South Carolina working with Dr. Mark G. Bowden, PT, Ph.D. Shortly after starting my post- doc position, I acquired a WOC appointment at the Ralph H. Johnson VA Medical Center and was awarded a VA Rehabilitation Research and Development Career Development Award – 1 that began in Oct 2019. Since the beginning of my research journey, I have published 22 peer-reviewed manuscripts, 12 as the first author. My most recent publications have centered on measuring the neurophysiological state of the nervous system and relating that state to post-stroke disability. These most recent manuscripts are based on data collected at the laboratories at Ralph H. Johnson before my arrival and the co-authors include several of the members of this proposal’s mentorship team. Upon completing my CDA-1 (end date Sep 30, 2021), I have focused my attention on the neurophysiological biomarkers of post-stroke fatigue. This CDA-2 proposal will provide me with the opportunity to learn new neurophysiological assessment methods and advance my knowledge and ability to apply neuromodulatory treatments. These skills will provide me the foundation to build an independent VA- backed research program focusing on reducing the impact of fatigue in Veterans with an array of neurological conditions. The assembled mentorship team is composed of experts in post-stroke rehabilitation, neuromodulation, neuroimaging, and clinical assessment. Up to 92% of people post-stroke experience fatigue. Fatigue negatively affects physical and mental performance leading to a lower quality of life. Fatigue is also present in many other neurological populations within the Veteran community, such as traumatic brain injury, multiple sclerosis, and the newly coined phenomenon of Long-COVID. Advances in the knowledge and understanding of post-stroke fatigue are likely to lead to advances in other clinical populations within the Veteran community. The first aim is to test the effects of a well-established neuromodulatory therapy, repetitive transcranial magnetic stimulation (rTMS), on reducing the severity of post-stroke fatigue. This aim is predicated on theoretical principles obtained from the study of other neuro-psychiatric/-cognitive disorders and therapeutic attempts to reduce fatigue in other neurological illnesses. Participating Veterans will receive high-frequency rTMS to the frontal lobe, either the left prefrontal dorsolateral cortex or bilaterally to the motor cortices. These locations have been implicated in fatigue in other neurological conditions. I expect to show rTMS can be used to reduce post-stroke fatigue severity. However, the effectiveness and location of treatment may partially be dependent on individual characteristics. The second aim of the study is based on the skills and knowledge developed in the CDA-1, I plan on identifying additional neurophysiological biomarkers of fatigue. In this project, I will assess glutamatergic activity/signaling of the upper and lower extremity sensorimotor network of Veterans with and without post-stroke fatigue. I expect to show that the fatigued group will show glutamatergic dysfunction, measured by greater asymmetries in intracortical facilitation and the facilitatory response to paired associative stimulation, compared to the non-fatigued group. Identification of glutamate and related metabolites as a pathophysiological contributor to post-stroke fatigue may help in the development of new therapeutic approaches for post-stroke fatigue and fatigue in other neurological conditions.", "keywords": [ "Affect", "American Heart Association", "Anxiety", "Appointment", "Attention", "Award", "Back", "Behavior", "Bilateral", "Bioenergetics", "Biological Markers", "Caregivers", "Characteristics", "Chronic Fatigue Syndrome", "Clinical", "Clinical assessments", "Cognition Disorders", "Coin", "Colorado", "Communities", "Contract Services", "Data", "Development", "Doctor of Philosophy", "Effectiveness", "Environment", "Evidence based treatment", "FDA approved", "Fatigue", "Foundations", "Frequencies", "Functional disorder", "Glutamates", "Goals", "Human", "Individual", "Intervention", "K-Series Research Career Programs", "Knowledge", "Laboratories", "Lead", "Learning", "Left", "Lesion", "Location", "Long COVID", "Lower Extremity", "Magnetic Resonance Spectroscopy", "Manuscripts", "Measures", "Medical", "Medical center", "Mental Depression", "Mental disorders", "Mentorship", "Methods", "Motor", "Motor Cortex", "Multiple Sclerosis", "Nature", "Nervous System Physiology", "Nervous system structure", "Neuraxis", "Neurocognitive", "Neurologic", "Peer Review", "Performance", "Persons", "Pharmacology", "Physical Function", "Physical activity", "Physiologic pulse", "Pilot Projects", "Play", "Population", "Positioning Attribute", "Post-Traumatic Stress Disorders", "Postdoctoral Fellow", "Prefrontal Cortex", "Prevalence", "Psyche structure", "Publications", "Publishing", "Quality of life", "Recording of previous events", "Rehabilitation therapy", "Research", "Research Personnel", "Role", "Scientist", "Services", "Severities", "Signal Transduction", "South Carolina", "Stroke", "Structure", "System", "Testing", "Therapeutic", "Training", "Transcranial magnetic stimulation", "Traumatic Brain Injury", "United States", "Universities", "Update", "Upper Extremity", "Veterans", "Veterans Health Administration", "Work", "active duty", "base", "career", "career development", "chronic stroke", "cognitive function", "college", "cost", "disability", "effective intervention", "effective therapy", "efficacy testing", "evidence base", "experience", "expiration", "frontal lobe", "improved", "insight", "member", "military veteran", "multidisciplinary", "negative affect", "nervous system disorder", "neural circuit", "neuroimaging", "neurophysiology", "neuropsychiatry", "neuroregulation", "noninvasive brain stimulation", "novel", "novel therapeutic intervention", "post stroke", "programs", "psychologic", "rehabilitation re" ], "approved": true } }, { "type": "Grant", "id": "5399", "attributes": { "award_id": "0748366", "title": "EPSCoR Cyberinfrastructure Assessment Workshop", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "EPSCoR Co-Funding" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-09-15", "end_date": "2008-08-31", "award_amount": 57302, "principal_investigator": { "id": 18886, "first_name": "John W.D.", "last_name": "Connolly", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 178, "ror": "", "name": "University of Kentucky Research Foundation", "address": "", "city": "", "state": "KY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 178, "ror": "", "name": "University of Kentucky Research Foundation", "address": "", "city": "", "state": "KY", "zip": "", "country": "United States", "approved": true }, "abstract": "This proposal for a workshop entitled \"EPSCoR Cyberinfrastructure Assessment Workshop\" was submitted July 19, 2007. To address the problem of the \"Cyberinfrastructure (CI) Gap\" between EPSCoR and non-EPSCoR jurisdictions, KY NSF EPSCoR proposes hosting a workshop that will expand on the groundwork developed at previous meetings and will ultimately result in a collaborative plan/proposal for proactively addressing CI in the EPSCoR jurisdictions. EPSCoR workshop participants will have CI expertise and performed an assessment within their respective jurisdictions to be able to present the current status of CI across the community. The first day of the workshop will consist of presentations by experts in CI from the EPSCoR jurisdictions about the capabilities and needs of the CI in their jurisdictions. Also included will be presentations by experts outside of the EPSCoR community who have set up interstate CI structures, such as networks and grids. The presentations by the outside experts will be focused on practical CI applications. The second day of the workshop will summarize the plans and extract common elements. This will lead to a coordinated plan for EPSCoR jurisdictions to share resources, e.g. a grid of computational resources with the appropriate software and expertise to make it function as a powerful scientific engine, and to provide easy access to other resources such as the NSF Teragrid.\n\nIntellectual Merit\nNSF recognizes that developing CI is inherently necessary for the nation to balance its research portfolio and to enhance the intellectual merit of future research. Cyberinfrastructure represents a changing platform for enabling the future of academic research. As this technology evolves, the EPSCoR jurisdictions run the risk of being left behind technically advanced states with robust network connections and sizable investments in high-end computing. In addition, EPSCoR jurisdictions represent diverse populations and a broad range of CI needs and conditions. The plan will position EPSCoR jurisdictions to develop the capabilities needed for future science and educational competitiveness. The results of this workshop can be carried on to the EPSCoR Annual Meeting in Hawaii where additional planning by EPSCoR jurisdiction project directors can formalize planning efforts and will ultimately result in a collaborative plan/proposal for proactively addressing CI in the EPSCoR jurisdictions.\n\nBroader Impacts\nThe broader impacts of the workshop include developing an EPSCoR-wide collaborative effort to actively address and shape the jurisdictions' response to the changing nature of academic research. This plan will necessarily include educational and training components, as there is a critical shortage of trained people in the EPSCoR jurisdictions to operate and maintain modern CI. The assessment will include CI needs for tribal and community colleges.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4117", "attributes": { "award_id": "1601521", "title": "Competency-Based, Open Entry, Open Exit Biotechnology Education (CBOE-Biotech)", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Advanced Tech Education Prog" ], "program_reference_codes": [], "program_officials": [], "start_date": "2016-06-15", "end_date": "2021-05-31", "award_amount": 819416, "principal_investigator": { "id": 13833, "first_name": "Jean", "last_name": "Bower", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1240, "ror": "https://ror.org/029z7h505", "name": "Salt Lake Community College", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1240, "ror": "https://ror.org/029z7h505", "name": "Salt Lake Community College", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "Salt Lake Community College (SLCC) will develop new competency-based, open-entry, open-exit program for their biotechnology credentials, complemented by an open lab during extended evening and weekend hours. This will allow SLCC to offer students and incumbent workers opportunities for flexible scheduling and accelerated program completion. The benefits to students will be reduced costs and enhanced well-being, especially for students who have families and jobs. Complementing the project is a targeted effort to recruit underserved populations. Working with the local biotechnology industry through an advisory board, the curriculum will be tailored to the needs of local employers to ensure it provides well-educated technicians for a growing industry. \n\nAs a result of this project, SLCC will develop new practices in competency-based, open-entry, open-exit instruction and delivery that increases student access to biotechnology education and helps them earn a credential. This flexibility will save students money and support family life. This project leverages an existing Title III grant from the Department of Education. The new curriculum will be informed by a DACUM process that involves input from local industry. This will ensure that it meets the evolving needs of Utah biotechnology companies, articulates with local baccalaureate degree program, and develops the student skills needed by industry. Through proactive mentoring and advising, use of student analytics, and project evaluation, this project will identify effective practices and potential pitfalls of competency-based education programs in technician education. Through dissemination via the ATE community, this project will become a model for other programs serving students with similar needs.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10571", "attributes": { "award_id": "1U01IP001182-01", "title": "RFA-IP-22-004, Multidisciplinary Approach to Understanding Vaccine Efficacy and Transmission of Viral Respiratory Tract Infections in the Real World", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-09-30", "end_date": "2027-09-29", "award_amount": 2483947, "principal_investigator": { "id": 26592, "first_name": "Stacey", "last_name": "House", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 827, "ror": "", "name": "WASHINGTON UNIVERSITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "– COMPONENT A Influenza and SARS-CoV-2 are major causes of morbidity and mortality and constitute the leading causes of vaccine preventable deaths in the United States. A better understanding of vaccine effectiveness for these viral pathogens is critical to drive public health decisions and interventions. We propose utilizing a multidisciplinary approach to conduct a test-negative study to determine influenza and SARS-CoV-2 vaccine effectiveness in ambulatory patients with respiratory tract infections. The team of investigators includes experts in emergency medicine, infectious disease, pediatrics, epidemiology, information technology, molecular microbiology, virology, and genetics. This team has extensive experience in automated electronic medical record alerts, high-volume subject recruitment of ambulatory patients with respiratory tract infections, rapid escalation/de-escalation of recruitment efforts to match viral circulation patterns, respiratory and blood sample processing and shipment, quality data collection and verification, and viral genomic sequencing necessary to ensure the success of this project. The proposed study will encompass the following specific aims: 1)Utilize innovative automated alerting strategies to identify and recruit a diverse population of ambulatory patients with acute respiratory illnesses; 2) Estimate influenza and SARS-CoV-2 vaccine effectiveness using a test- negative study design in the general population as well as different demographic subgroups.; 3) Explore factors that influence influenza and SARS-CoV-2 vaccine effectiveness such as co-morbidities, vaccination type and schedule, and social determinants of health; 4) Determine effect of viral vaccination status on health outcomes in ambulatory patients with influenza and SARS-CoV-2 infection; 5) Contribute biospecimens and viral genomic sequencing data to a national repository of subjects with PCR-confirmed influenza or SARS-CoV-2 infection. To accomplish these goals, we will enroll at least 1000 ambulatory patients/year with acute respiratory tract infections in the proposed study. The subject population will be identified from the emergency departments of 3 large hospitals in the St. Louis area and their associated outpatient clinics. The available patient population at these enrolling sites is diverse with respect to race, ethnicity, age, socioeconomic status, and medical care access which will enhance the generalizability of the study outcomes to the US population.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10991", "attributes": { "award_id": "5I01BX005469-02", "title": "COVID-19: Elucidating monoclonal and polyclonal seroantibody responses to the COVID-19 viral envelope", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2023-09-30", "award_amount": null, "principal_investigator": { "id": 24795, "first_name": "Mohammad Mohseni", "last_name": "Sajadi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1532, "ror": "https://ror.org/036a0e562", "name": "Baltimore VA Medical Center", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1532, "ror": "https://ror.org/036a0e562", "name": "Baltimore VA Medical Center", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Background/Rationale: As the Coronavirus Disease 2019 (COVID-19) epidemic expands across the United States and the world, there are no proven therapies and little information is known regarding on immunity to this virus. At this stage of the pandemic, all prevention and treatment strategies that show promise must be explored. This proposal will focus on the polyclonal and monoclonal antibody responses to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) envelope. Objectives: The overarching goal of this program is to obtain a comprehensive understanding of the polyclonal and monoclonal response to the SARS-CoV-2 envelope E, M, and S proteins. The specific aims of this proposal are: 1) Deconvolute the polyclonal antibody response against the viral envelope of SARS-CoV-2; 2) Isolate neutralizing and non-neutralizing monoclonal antibodies against various epitopes of spike protein (S), envelope protein (E), and membrane glycoprotein (M) of SARS-CoV-2; and 3) Map the corresponding epitope(s) of the monoclonal antibodies. Methods: We will obtain paired, acute and convalescent, samples from 60 inpatients and outpatients with COVID-19 (30 have already been enrolled from the VA Maryland Health Care System and the University of Maryland Medical System). We will screen samples by binding, live and pseudovirus neutralization. In this proposal, we also will have access to BSL3 facilities on this campus that run neutralization assay with live virus by one of the world experts in coronaviruses (Matt Frieman, PhD). Donors will be ranked on the basis of both neutralization potency and breadth, and binding. The top three donors in each of the inpatient and outpatient groups will be chosen for further study (top anti-RBD neutralization and breath, top anti- receptor binding domain (RBD)-depleted plasma neutralization and breath, and top spike binding titers with non-neutralizing plasma). In these six individuals, the anti-envelope antibody will be affinity purified; and fractionated using free- flow-electrophoresis. This technique can separate antibodies based on charge, which will lead to separation based on targeted epitopes as well. Individual fractions will be tested by binding and neutralization; and characteristic biochemical and functional signatures of antibodies targeting each epitope will be ascertained. Fractions of interest (different for each donor depending if neutralization or binding is targeted) will be sent for mass spectrometry. B cell libraries will also be made from the convalescent IgG and IgA memory B cell pools; and they will be interrogated using three complementary techniques including - acute phase plasmablast repertoire analysis, subtraction analysis, and antigen baiting to identify potential antibodies. Finally, mass spectrometry will be used to rank antibody candidates. 40 monoclonal antibodies (mAbs) will be made and again be screened by neutralization potency, breadth, and isoelectric point, with top neutralizing and binding antibodies (matching the respective profiles of the fractions that were targeted) to be moved forward for fine epitope analysis by X-ray crystallography. Impact: If successful, this project will yield a substantial understanding of neutralizing/non-neutralizing antibodies and epitopes in COVID-19 disease, providing mAbs that can be moved into animal/human testing. This research has direct relevance to the health of Veterans as any monoclonal antibodies isolated can potentially be used for treatment and/or prevention of COVID-19.", "keywords": [ "2019-nCoV", "Acute", "Affinity Chromatography", "American", "Animals", "Antibodies", "Antibody Response", "Antigens", "Award", "B-Lymphocytes", "Binding", "Binding Sites", "Biochemical", "Biological Assay", "COVID-19", "COVID-19 patient", "COVID-19 prevention", "Categories", "Cells", "Cessation of life", "Characteristics", "Charge", "Codon Nucleotides", "Coronavirus", "Disease", "Doctor of Philosophy", "Electrophoresis", "Enrollment", "Epidemic", "Epitope Mapping", "Epitopes", "Family", "Fractionation", "Goals", "HIV", "Hand", "Health", "Healthcare Systems", "Human", "Immunity", "Immunoglobulin A", "Immunoglobulin G", "Individual", "Infection", "Inpatients", "Isoelectric Point", "Knowledge", "Libraries", "Maps", "Maryland", "Mass Spectrum Analysis", "Medical", "Membrane Glycoproteins", "Memory B-Lymphocyte", "Methods", "Monoclonal Antibodies", "Nucleoproteins", "Outpatients", "Patients", "Persons", "Phase", "Plasma", "Plasmablast", "Plasmids", "Prevention strategy", "Production", "Proteins", "Protocols documentation", "Research", "Running", "SARS-CoV-2 antibody", "SARS-CoV-2 infection", "SARS-CoV-2 spike protein", "Sampling", "System", "Techniques", "Testing", "United States", "Universities", "Vaccines", "Veterans", "Viral", "Virus", "X-Ray Crystallography", "biosafety level 3 facility", "convalescent plasma", "env Gene Products", "experience", "experimental study", "interest", "multiple myeloma M Protein", "neutralizing antibody", "novel therapeutics", "novel vaccines", "pandemic disease", "participant enrollment", "polyclonal antibody", "programs", "receptor binding", "response", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "11529", "attributes": { "award_id": "5I01RX003622-02", "title": "Exercise-based Program for Rehabilitation of Veterans with Severe Mental Illness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-06-01", "end_date": "2026-05-31", "award_amount": null, "principal_investigator": { "id": 23883, "first_name": "GRETCHEN L", "last_name": "HAAS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23884, "first_name": "Vishwajit Laxmikant", "last_name": "Nimgaonkar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "This is a Hybrid 1, effectiveness-implementation study of yoga-based exercise (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI), defined here as schizophrenia (SZ), schizoaffective disorder (SZA) and bipolar I disorder (BP1). SMIs are common, severe and devastating conditions that cause enormous disability world-wide. Many features of SMI can be treated effectively, yet the long-term outcome has not improved much over the past century. The lack of improvement may be due to ineffective treatment of functional deficits in SMI patients, particularly in terms of community functioning, defined here as social, leisure, employment, and life skills functioning in the community. Complementary and Integrative Medicine (CIM) therapies that improve community functions are thus of great interest for treating Veterans with SMI and thereby target an area of high priority for the VA. Prior studies have shown short-term benefits of YE for improving cognitive deficits and community functions among persons with SMI. While the published studies are encouraging, the longer-term benefits of YE are untested, particularly for community functioning. The profile of Veterans with SMI who will accept and adopt YE is also unknown. We have conducted pilot studies and a randomized controlled trial (RCT) for individuals with SMI in India using short-term, simplified YE combined with medications. Recently, we also concluded RELIEVE, a RCT of adjunctive YE for Veterans with post-traumatic stress disorder (PTSD) in the USA (VA RR&D Merit award, PI: L Davis, PsyD). We found encouraging improvements from all our studies, but our Indian and US YE protocols are impractical for Veterans with SMI. For example, some postures may be difficult for older Veterans with amotivation and/or physical disabilities. Therefore, in Aim 1, we will design and evaluate adaptations of the Indian and US YE protocols in a non-religious context (mindfulness, stretching, toning and breathing exercises). We will consult our Indian and US colleagues, our Veterans with SMI and their VA therapists to adapt the protocol for our SMI population. We will also adapt our control condition, the Wellness Lifestyle Program (WLP), from our recently completed RELIEVE study. In Aim 2, we will conduct a 2-armed RCT in which consenting Veterans with SMI will be randomly assigned to one of 2 arms: YE and treatment as usual (TAU, any prescribed treatment) or WLP+ TAU. Unlike prior short-term YE RCTs, the two arms will continue 12 months, including an initial 12-week training period consisting of two supervised sessions per week, followed by a 12-week training period consisting of one supervised session per week, and monthly refresher training sessions offered for the remaining 6 months. We will conform to all COVID-19 related requirements for YE and WLP. Our Hybrid 1 trial will compare the efficacy of YE versus WLP. Primary outcomes are self-report and performance-based measures of community functioning; secondary outcomes are cognition and physical fitness measures. Our goals in Aim 3 are to understand demographic/clinical features of Veterans with SMI who are more likely to accept and adopt YE to enable long-term rehabilitation, by analysis of the RCT data (Aim 3A). We will also conduct qualitative interviews with Veterans who have SMI and participated in the YE intervention arm, referring clinicians, and the Yoga instructor to identify barriers and facilitators for implementation (Aim 3B). The project thus aims to advance our long-term goals for improving the quality of life for Veterans with SMI and to provide evidence to guide home- based and over the longer term, community-based YE practice, consistent with the Mission Act and the VA Strategic Plan. Our experience in conducting a variety of SMI research for over 25 years offers strong support for successful completion of the proposal.", "keywords": [ "Adopted", "Adoption", "Affect", "Area", "Award", "Bipolar I", "Breathing Exercises", "COVID-19", "Characteristics", "Clinic", "Clinical", "Cognition", "Cognitive deficits", "Communities", "Community Integration", "Complementary Medicine", "Consent", "Consolidated Framework for Implementation Research", "Consult", "Data", "Disease", "Elements", "Employment", "Ensure", "Exercise", "Family", "Frequencies", "Goals", "Health", "Health Personnel", "Healthcare", "Home", "Hybrids", "Impaired cognition", "Impairment", "India", "Individual", "Integrative Medicine", "Intervention", "Interview", "Leisures", "Life", "Life Style", "Measures", "Mental Health", "Mission", "Muscle Contraction", "Outcome", "Participant", "Patient Self-Report", "Patients", "Pattern", "Persons", "Pharmaceutical Preparations", "Physical Fitness", "Pilot Projects", "Population", "Post-Traumatic Stress Disorders", "Posture", "Prevalence", "Protocols documentation", "Publishing", "Quality of life", "Randomized", "Randomized Controlled Trials", "Recording of previous events", "Refractory", "Regulation", "Rehabilitation therapy", "Relaxation", "Research", "Research Design", "Role", "Rural Community", "Safety", "Schedule", "Schizoaffective Disorders", "Schizophrenia", "Services", "Social Functioning", "Socialization", "Strategic Planning", "Stretching", "Substance Use Disorder", "Suicide prevention", "Symptoms", "Techniques", "Testing", "Time", "Training", "Veterans", "Yoga", "alcohol use disorder", "arm", "cognitive benefits", "comorbidity", "comparative efficacy", "cost", "design", "disability", "effectiveness/implementation study", "efficacy study", "exercise intervention", "exercise program", "exercise training", "experience", "future implementation", "implementation efforts", "implementation facilitators", "improved", "ineffective therapies", "instructor", "interest", "long-term rehabilitation", "mindfulness", "performance based measurement", "physically handicapped", "primary outcome", "programs", "secondary outcome", "severe mental illness", "skills", "social", "study characteristics", "tool", "treatment arm", "treatment as usual", "uptake", "virtual", "whole health" ], "approved": true } }, { "type": "Grant", "id": "4173", "attributes": { "award_id": "1608537", "title": "The new identity of galectin-3 as a glycosaminoglycan binding protein", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Chemistry of Life Processes" ], "program_reference_codes": [], "program_officials": [], "start_date": "2016-09-01", "end_date": "2021-08-31", "award_amount": 420965, "principal_investigator": { "id": 14049, "first_name": "Tarun", "last_name": "Dam", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 512, "ror": "https://ror.org/0036rpn28", "name": "Michigan Technological University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 512, "ror": "https://ror.org/0036rpn28", "name": "Michigan Technological University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Glycan-binding proteins are crucial for a wide range of biological processes. They belong to two distinct groups: lectins and glycosaminoglycan (GAG)-binding proteins (GAGBPs). A member of one group rarely possesses the characteristics of both groups. The human lectin Galectin-3 (Gal-3) is a member of the first group. This project is based on the finding that Gal-3, a lectin, actually possesses characteristics of a GAGBP. The current study investigates these newly-discovered characteristics of Gal-3. The research is integrated with educational activities through an initiative called \"From Bench to Blackboard.\" This initiative introduces glycobiology to high school students and K-12 teachers through lab- and web-based approaches. The anticipated results from the proposed work is revealing hitherto unknown properties of Gal-3 and will inspire new research activities involving Gal-3 and GAGs.\n\nGal-3 is one of the most extensively studied human lectins but it has never been reported as a GAGBP. However, preliminary data for this study show that Gal-3 binds to sulfated GAGs and proteoglycans. The proposed research elucidates the detailed interactions of Gal-3 with GAGs and proteoglycans. The length and sulfation level of GAGs, that are optimal for binding by Gal-3, are determined by calorimetry and spectroscopy. The GAG binding site of Gal-3 is being delineated with the use of site directed mutagenesis. Various biophysical techniques are employed to study non-covalent cross-linking of Gal-3 by GAGs and proteoglycans. In addition, competitive cross-linking of Gal-3 by GAGs and glycoproteins is also being examined. Information obtained from this research is redefining the binding properties of Gal-3 and providing a foundation for discovering Gal-3 dependent cellular and extracellular functions of GAGs and proteoglycans.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5410", "attributes": { "award_id": "0709500", "title": "Discovery, Follow-up, and Calibration of Near-Earth Objects", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "PLANETARY ASTRONOMY" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-09-01", "end_date": "2011-08-31", "award_amount": 300000, "principal_investigator": { "id": 18915, "first_name": "David", "last_name": "Tholen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 684, "ror": "", "name": "University of Hawaii", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 684, "ror": "", "name": "University of Hawaii", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true }, "abstract": "AST 0709500\nTholen\n\nDr. Tholen will use this award to address three tasks related to near-Earth objects (NEOs). The first task is a continuation of efforts to find new NEOs at solar elongations of less than 90 deg, where objects in certain types of orbits can spend the majority, if not the entirety, of their time. The second\ntask is for follow-up astrometry of NEOs, concentrating on objects in the 20 to 24 apparent magnitude range, where little follow-up capability currently exists. The third task involves the acquisition of calibrated photometry of NEOs in the 17 to 19 absolute magnitude range to do a\nbetter job of determining the true number of objects brighter than absolute magnitude 18. \n \nThe Earth orbits the Sun in a swarm of asteroidal debris ranging in size from roughly 10 km down to tiny dust particles. The size-frequency distribution of this debris is such that only a few objects exist at the large end of the distribution, while billions of dust particles pervade the inner Solar System. The rate of collision between these objects and the Earth is proportional to their number. While collisions with dust particles are essentially continuous, the visible manifestation being known as meteors, collisions with larger objects are correspondingly rarer. A 50 m object hits the Earth every few hundred years, the most recent example being the Tunguska event of 1908. The effects of even larger objects colliding with the Earth are potentially devastating, the demise of the dinosaurs 65 million years ago being attributed to the impact of a 10 km object. To inventory potentially hazardous asteroids, several groups are surveying the Solar System beyond the orbit of the Earth, but little attention has been given to the region of the Solar System interior to the Earth's orbit. Previous survey work at small solar elongations has resulted in perhaps the most significant NEO discovery to date, that of (99942) Apophis, a 300 m object that will pass within 6 Earth radii on 2029 April 13. During a 20-year span centered on the date of discovery, this object spends 95 percent of its time at solar elongations of less than 90 deg. How many other similar objects are there? This program is designed to answer that important question.\n \nAstrometric follow-up of the brighter NEOs found by the professional surveys is an activity that involves hundreds of amateur astronomers throughout the world, with no gender, ethnic, or geographic boundaries. This survey will be no different in this regard. The project will directly involve a postdoctoral fellow and/or a graduate student, thus providing both education and training in the subjects of astrometry, photometry, and celestial mechanics. Because of the apparent connection between asteroid impacts and the extinction of the dinosaurs, the subject of near-Earth asteroids has become nearly as popular with younger students as has the subject of dinosaurs. It provides the opportunity to educate the public about the structure of the Solar System beyond the eight major planets traditionally memorized in grade school. And although the probability of finding an object of significant size on a collision course with Earth in the near future is quite small, the broader impact of such a discovery would be enormous, including the topics of disaster preparation, impact prediction, and threat mitigation. So popular has the subject become in recent years that it has spawned two major theatrical motion pictures, a television mini-series, and numerous documentaries.\n***", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 2, "pages": 1405, "count": 14046 } } }