Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=2&sort=other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators" }, "data": [ { "type": "Grant", "id": "15245", "attributes": { "award_id": "4R00AA030628-03", "title": "Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptors", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 12239, "first_name": "Qi-Ying", "last_name": "Liu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-25", "end_date": "2027-07-31", "award_amount": 249000, "principal_investigator": { "id": 27208, "first_name": "Meghan Elizabeth", "last_name": "Flanigan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has greatly exacerbated rising patterns of excessive alcohol consumption, particularly in women. Binge alcohol drinking is the most common pattern of excessive alcohol drinking and is associated with increased risk of developing mood disorders and Alcohol Use Disorder (AUD). Social support strongly buffers against alcohol craving and relapse, yet many individuals display reduced valuation of social rewards and/or deficits in the processing of social stimuli following alcohol exposure and subsequent abstinence. This may compound interpersonal problems in people with AUD and limit their capacity to seek out or receive social support. Therefore, understanding the neurobiological mechanisms mediating alcohol’s effects on social behavior is required to inform future treatments aimed at enhancing social functioning and reducing relapse in patients with AUD. Drinking in the Dark (DiD) is a robust paradigm for investigating the circuit and molecular mechanisms of binge-like alcohol consumption on physiology and behavior in rodents. In addition, the 3-chamber sociability model permits the interrogation of both social reward and social recognition behaviors following alcohol consumption. Serotonin (5-Hydroxytryptamine, 5-HT) receptor signaling in the lateral habenula (LHb) has been implicated in the development of negative emotional states associated with abstinence from alcohol, but the LHb remains highly understudied in the context of AUD. I recently found that DiD reduced social recognition selectively in female mice during abstinence, and that genetic deletion of the LHb Gq-protein coupled serotonin receptor 5HT2c partially prevented this effect. My preliminary data suggests that binge alcohol consumption enhances the intrinsic excitability of LHb 5HT2c-containing neurons (LHb5HT2c) in the medial sub- region, that 5-HT is released onto LHb5HT2c during social interaction, and that acute engagement of Gi signaling in LHb5HT2c can normalize social deficits induced by alcohol. Moreover, DiD appears to modulate the expression of multiple 5-HT receptor subtypes co-expressed in LHb5HT2c. Together, these data suggest that excessive activation of LHb5HT2c via dysregulation of 5-HT receptor signaling may underlie social deficits induced by alcohol. Using these preliminary findings as a foundation for the current proposal, I will 1) characterize how DiD alters the translational and physiological landscape of LHb5HT2c projecting to the DRN (5HT2cLHb-DRN) and 2) investigate the functional impact of genetic manipulation of 5-HT receptor sub-types in 5HT2cLHb-DRN on neuronal physiology and DiD-induced dysregulation of social behavior. Together, these experiments will determine the effects of binge alcohol drinking on molecular and physiological processes in 5HT2cLHb-DRN and identify novel mechanisms by which these neurons promote social dysfunction during abstinence. Furthermore, this award will provide me with valuable technical and professional training that will facilitate my transition to independence.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15174", "attributes": { "award_id": "1R03HS030016-01A1", "title": "Assessing the Impact of Health System Ownership on Fulfilling the Vision of High-Quality Primary Care and Whole Health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 27219, "first_name": "Aimee", "last_name": "Eden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-01", "end_date": "2026-08-31", "award_amount": 49777, "principal_investigator": { "id": 31759, "first_name": "E. Marshall", "last_name": "Brooks", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 672, "ror": "https://ror.org/02nkdxk79", "name": "Virginia Commonwealth University", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true }, "abstract": "TITLE: Assessing the Impact of Health System Ownership on Fulfilling the Vision of High-Quality Primary Care and Whole Health PROJECT SUMMARY The National Academies of Sciences, Engineering, and Medicine’s (NASEM) reports “Implementing High Quality Primary Care'' and “Achieving Whole Health: A New Approach for Veterans and the Nation'' call for coordinated systems level approaches to care.1,2 In response to these calls for action and stresses on primary care from the COVID pandemic and other market forces, primary care practices are increasingly owned by health systems. In Virginia we have documented that between 2018 and 2022 there was an increase from 25% to 43% of practices being owned by a health system with a concurrent decline in clinician ownership.3 These changes could both help (e.g., provide a systems level approach, expanded interprofessional teams, new resources) and/or undermine (e.g., reduce local decision-making authority, replace ambulatory focus with hospital interests, undermine organizational culture) the ability to achieve NASEM’s vision. We propose an explanatory sequential mixed-methods study using multimedia elicitation surveys and focus group interviews to assess the impact of ownership on high-quality primary care and whole health care and to describe contextual factors that may impact care. Building on our ongoing, longitudinal assessment of primary care in Virginia conducted in the Ambulatory Care Outcomes Research Network (ACORN), we will randomly sample 30 primary care practices throughout the state, stratified by practices that in the past 5 years (a) moved from clinician to hospital ownership, (b) stayed clinician owned, or (c) stayed hospital owned. The survey will consist of a brief multimedia presentation, developed in collaboration with the NASEM report authors, of the key elements of high-quality primary care and whole health, immediately followed by Likert scale questions to assess team members’ attitudes, current practice, and confidence in the ability to improve on these elements. The survey will be digitally administered with REDCap software to representatives of each clinical team member type. To develop the multimedia elicitation survey, we will work with the NASEM report authors and committee members to distill and operationalize core elements articulated in the reports, including questions on equity, accessibility, integration, interprofessional teamwork, professional satisfaction and team wellbeing, and community engagement. A practice structural questionnaire will also collect information on practice organization and staffing levels, patient volume and population demographics, payer mix, EHR capabilities, enhanced access options, and participation in innovative payment models. Follow-up group interviews with practice teams will reflect on team survey responses and assess the organizational, practice, and individual level factors influencing high-quality primary care and whole health care. Study findings will be used to further AHRQ’s mission of revitalizing the Nation’s primary care system, promote the NASEM vision of Whole Health in primary care, and develop future interventions to help primary care deliver high-quality and whole health care in diverse ownership settings.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15294", "attributes": { "award_id": "1R01EB035594-01", "title": "Designing a deployable and adaptable plasmonic sensing platform for infectious disease surveillance", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 27406, "first_name": "SHAWN PATRICK", "last_name": "Mulvaney", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-01", "end_date": "2028-04-30", "award_amount": 326944, "principal_investigator": { "id": 31885, "first_name": "Pietro", "last_name": "Strobbia", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1446, "ror": "https://ror.org/01e3m7079", "name": "University of Cincinnati", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "This proposal aims to address the critical need for cost-effective, sensitive, and accurate point-of-need (PON) testing for infectious diseases by developing an adaptable and deployable sensing platform. Currently available molecular diagnostic tests, such as polymerase chain reaction (PCR) and lateral flow assays (LFA), exhibit limitations in terms of either ease of deployment or accuracy and sensitivity. This tradeoff between accuracy and cost-effectiveness/distribution has hindered the containment of the current pandemic and could limit our surveillance capabilities of emerging diseases. To overcome these challenges, we propose to develop catalytic surface-enhanced Raman scattering (SERS) sensors based on functional DNA sequences, offering several advantages over existing diagnostic methods. The long-term goal of this project is to create a sensing platform capable of detecting multiple genetic biomarkers in liquid biopsies, enabling effective PON diagnostics. The proposed SERS sensors provide highly multiplexed assays, improving accuracy in pathogen and variant identification. Furthermore, these sensors offer quantifiable results that can be used for prognostic purposes, enabling viral load determination. These SERS sensors are easily deployable and exhibit superior sensitivity compared to LFA, resulting in more accurate PON diagnostic tests. In this project, we plan to leverage inverse design and machine learning techniques to study the key functional DNA features that influence sensor performance. The insights gained for optimal design rules will be used to develop an automated sensor design algorithm capable of producing designs with predictable figures- of-merit, given a target genetic code. Additionally, we aim to exploit the reagentless feature of the sensors by developing lyophilized sensing tablets containing all necessary components for the sensing process. These tablets enable on- demand testing by simply adding the sample, thereby providing a practical means to administer this one-pot SERS assay at the PON. To validate these advancements, a multiplexed assay will be developed to detect SARS-CoV-2 and validated on saliva samples containing various inactivated viruses from different SARS-CoV-2 variants. We will test the diagnostic accuracy in the identification of viral load and specific variants.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15256", "attributes": { "award_id": "1R01AI179891-01", "title": "A Rapid Phenotypic Drug Susceptibility Testing System for Tuberculosis", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 7856, "first_name": "Karen A.", "last_name": "Lacourciere", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-23", "end_date": "2029-06-30", "award_amount": 610516, "principal_investigator": { "id": 31844, "first_name": "Mireille", "last_name": "Kamariza", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 818, "ror": "", "name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Tuberculosis (TB) is second only to COVID-19 as the most lethal cause of death from a single infectious agent. In 2020, an estimated 10 million people developed TB, nearly half a million of which were infected with drug- resistant tuberculosis (DR-TB). Early detection of infection and drug resistance is critical to controlling DR-TB as this enables rapid engagement into effective care. Unfortunately, only 71% of newly diagnosed TB patients are ever tested for rifampicin resistance, and even fewer receive more comprehensive testing. Additionally, despite improved treatment success rates for DR-TB globally, these success rates do not reflect upstream losses resulting from undiagnosed (missing cases) and untreated patients. Currently, bacterial culture and nucleic acid testing remain the primary methods for diagnosing infection, with smear microscopy being phased out. However, these methods present significant limitations for diagnosing drug resistance such as lengthy time-to-result for phenotypic tests, as well as the need for a priori knowledge of resistance mutations and prohibitive cost for molecular tests. Clearly, there remains a critical need for a fast, accurate, and cost-effective DST, particularly for resource-limited settings. To address this, we propose to design and develop a rapid phenotypic drug susceptibility test that can be easily adapted in TB endemic regions. The trehalose- based DST, termed Tre-DST, is based on novel trehalose probes, which require metabolic conversion to emit fluorescent signals, giving them their unique ability to specifically detect live Mycobacterium tuberculosis (Mtb). Agnostic to mechanism(s) of drug resistance, Tre-DST can be used with all WHO-recommended DRTB drugs, as well as any future TB drugs as a companion diagnostic. In Aim 1, we will develop, characterize, and optimize a family of novel fluorescent trehalose probes (3HC-Tre and RMR-Tre) that are specifically designed to improve performance over DMN-Tre and to distinguish live Mtb, making them ideal as biomarkers of drug susceptibility. We will also evaluate probe specificity to TB and probe performance across a variety of bacteria typically present in oral mucosa. In Aim 2, we will develop and optimize Tre-DST as a multi-drug DST for first- and second-line TB drugs. We will evaluate Tre-DST’s performance in accurately determining drug resistance using drug susceptible and drug resistant Mtb strains, treated singly and in combination with the anti- TB drugs that fulfill the WHO Target Product Profile (TPP) for next generation DST. We will also evaluate several point-of-care (POC)-friendly detection methods to optimize efficiency and cost-effectiveness. Lastly, in Aim 3, we will perform preliminary evaluation using banked clinical isolates in Johannesburg, South Africa to assess the performance of Tre-DST in the field. We will evaluate pre-validated readout methods in this clinical study, benchmarking the performance of Tre-DST against bacterial culture.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "16179", "attributes": { "award_id": "5F31DA063126-02", "title": "A statewide examination of the address-level relationships between residential eviction proceedings and overdose events in Rhode Island", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 44305, "first_name": "ERIN MARGARET", "last_name": "PARKER", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-09-01", "end_date": "2027-08-31", "award_amount": 50114, "principal_investigator": { "id": 44306, "first_name": "Alexandra", "last_name": "Skinner", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 3365, "ror": "", "name": "BROWN UNIVERSITY", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "PROPOSAL SUMMARY In the wake of the COVID-19 pandemic, overdose mortality and affordable housing shortages have reached unprecedented levels in Rhode Island and across the United States. Housing insecurity is a known risk factor for overdose, yet the effects of residential eviction—a structural and policy-sensitive cause of housing insecurity—on overdose risks are understudied. Eviction is a complex legal process composed of a series of stages, each of which may impact overdose risk and thus offers opportunity for public health intervention. The objective of this proposal is to pursue a thorough examination of the relationship between residential eviction proceedings (i.e., filing, hearing, and enforcement) and overdose at the address level in Rhode Island, to better inform eviction prevention policies that complement ongoing harm reduction and overdose prevention efforts. The proposed research will leverage the wealth of centralized, high-resolution data available in Rhode Island—and our team’s established relationship with the state health department—to construct a longitudinal dataset with data linked from several administrative sources. We will first characterize the prevalence and time course of eviction proceedings relative to non-fatal or fatal overdose events by conducting sequence and cluster analyses to operationalize variation in the order, duration, and timing of eviction proceedings before and after a given overdose event (AIM 1). We will then estimate the address-level causal effect of residential eviction proceedings on risk of non-fatal and fatal overdose, both overall and by race and ethnicity of overdose decedents, using a sequential target trial approach (AIM 2). The proposed research will be among the first of its kind to link eviction records with address-level health data to characterize heterogeneity in the duration and timing of eviction proceedings, to examine a causal link between eviction and overdose, and to explore differential impacts of eviction on overdose death by race and ethnicity. Because eviction is an intervenable mechanism of housing vulnerability that may be associated with overdose risk, findings from this work may elucidate novel avenues for addressing the intersecting housing and overdose crises in tandem. The proposed research will be completed by the principal investigator with support and mentorship from collaborators with substantial expertise in advanced quantitative methods for life course epidemiology and causal inference. The training activities detailed in this application, focused on advancing skills in epidemiologic study design and longitudinal data analysis and developing a deep contextual knowledge of the social and legal implications of eviction proceedings, will prepare the principal investigator for a career as an independent social epidemiologist and academic researcher.", "keywords": [ "Acute", "Address", "Alaska Native population", "American Indian Population", "Applied Skills", "Black race", "COVID-19 pandemic", "Censuses", "Characteristics", "Cluster Analysis", "Complement", "Complex", "County", "Data", "Data Linkages", "Data Set", "Discrimination", "Dose", "Drug user", "Economics", "Epidemiologic Research Design", "Epidemiologist", "Ethnic Origin", "Event", "Exposure to", "Funding", "Goals", "Harm Reduction", "Health", "Hearing", "Heterogeneity", "Hispanic", "Housing", "Individual", "Intervention", "Knowledge", "Learning", "Legal", "Life course epidemiology", "Link", "Mentorship", "Methodology", "Methods", "Neighborhoods", "Overdose", "Patients", "Policies", "Prevalence", "Prevention", "Principal Investigator", "Process", "Race", "Records", "Research", "Research Personnel", "Rhode Island", "Risk", "Risk Factors", "Sequence Analysis", "Series", "Shapes", "Source", "Structural Models", "Time", "Training", "Training Activity", "United States", "United States National Institutes of Health", "Variant", "Work", "career", "causal inference", "chronic exposures", "data management", "epidemiology training", "health data", "high-resolution", "housing insecurity", "legal implication", "life course", "longitudinal analysis", "longitudinal dataset", "longitudinal research", "marginalized community", "mortality", "neglect", "novel", "overdose death", "overdose prevention", "overdose risk", "psychosocial", "public health intervention", "residence", "response", "risk prediction", "segregation", "skills", "social", "social implication", "stressor", "structural health determinants" ], "approved": true } }, { "type": "Grant", "id": "15264", "attributes": { "award_id": "1R01MD019749-01", "title": "Motivate, Vaccinate, Activate’: An effectiveness-implementation trial to assess the impact of a multi-component community-based intervention to increase RSV vaccine uptake among Latino older adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6029, "first_name": "JARRETT AINSWORTH", "last_name": "Johnson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-26", "end_date": "2029-02-28", "award_amount": 686134, "principal_investigator": { "id": 31852, "first_name": "Carina", "last_name": "Marquez", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Respiratory Syncytial Virus (RSV) causes a substantial burden of hospitalizations and deaths among older adults, comparable to that of influenza. The new and effective RSV vaccines have the potential to dramatically reduce RSV morbidity and mortality, yet their full public health impact will not be realized if the racial and ethnic disparities in RSV vaccine uptake mirror those observed in other respiratory virus-vaccines, from COVID-19 to influenza. We have the opportunity to adapt community-based interventions from the COVID-19 pandemic to proactively address disparities in RSV vaccine uptake. However, evidence-based data, conducted in partnership with impacted communities, are essential. This project will focus on increasing RSV vaccine uptake among Latinos, a community disproportionatly affected by respiratory vaccines and RSV. We will leverage our well-established community-academic partnership, Unidos en Salud, to adapt two components of our ‘Motivate, Vaccinate, Activate’ intervention— CHW counseling and text message nudges. This multi-component intervention was originally designed to increase COVID-19 vaccine uptake among Latinos and to activate people to recommend vaccination to people in one’s social network. Our overall study objective is to adapt this intervention to inform effective and customizable community-based strategies to increase RSV vaccine uptake. In addition to a rigorous randomized trial design, we will collect detailed implementation outcomes to aide in generalizability and adaption to other vaccines and settings. Our primary hypothesis is that language-and culturally-concordant CHW motivation and activation counseling sessions, coupled with text message nudges, will increase RSV vaccine confidence by adressing trust, knowledge, and access-related barriers. The proposed study has three aims. In Aim 1 we will use the ADAPT-IT framework to adapt two intervention components: CHW counseling and text-message nudges to increase RSV vaccine uptake among Latino older adults (>60 years) (Aim 1a) and enable younger adults (18-50 years old) to discuss RSV vaccination with older adults in their social and family networks (Aim 1b). Then in Aim 2 we will conduct a two-arm type-1 effectiveness implementation trial to determine the effectiveness and implementation of a CHW counseling and text-message intervention on RSV vaccine uptake in Latino adults >60 years. In Aim 3, using a parallel trial design and social network analytic techniques, we will test the effectiveness of CHW counseling and text-message nudges on activating Latino adults to discuss RSV vaccination with the older adults within their social networks. The proposed work will provide timely, rigorous, and adaptable data to directly inform community-based approaches to increase RSV vaccination. In addition to providing timely data to reduce RSV vaccine disparities, these data will also advance our scientific understanding of the effectiveness of text-messages from community-based organizations and community-based interventions aimed at activating cross-generational social networks to boost vaccine uptake.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15310", "attributes": { "award_id": "1IK2CX002768-01A1", "title": "Effects of Exercise Training on Blood Microclots, Tissue Oxygenation, and Mitochondrial Health in Veterans with Post COVID Conditions", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2024-10-01", "end_date": "2029-09-30", "award_amount": null, "principal_investigator": { "id": 31897, "first_name": "Sausan Mousa", "last_name": "Jaber Taha", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1532, "ror": "https://ror.org/036a0e562", "name": "Baltimore VA Medical Center", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "15337", "attributes": { "award_id": "1R21AI183188-01A1", "title": "Structural investigations of coronavirus spike protein", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 27781, "first_name": "Mary Katherine Bradford", "last_name": "Plimack", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-26", "end_date": "2026-08-31", "award_amount": 247750, "principal_investigator": { "id": 28219, "first_name": "Syed Saif", "last_name": "Hasan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 793, "ror": "", "name": "UNIVERSITY OF MARYLAND BALTIMORE", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The spike (S) protein decorates the surface of coronavirus (CoV) particles such as SARS-CoV-2 and enables CoV's to enter and infect host cells. The S protein is the immunogen in genetic and subunit vaccines against COVID-19, which were critical in controlling the COVID-19 global pandemic. In cells that are infected with CoV's or have received a genetic vaccine, the S protein is synthesized in the mammalian cell endoplasmic reticulum (ER), and then trafficking via the secretory pathway consisting of ER, Golgi network, and plasma membrane (PM). This secretory trafficking of S is bidirectional between ER and Golgi, which are the secretory organelles that provide the enzymatic machinery for post-translational modifications, remodeling, and maturation. This includes enzymes for N-glycosylation, which modulates S folding, viral entry, and interactions with the host immune system. Structure-function investigations have shown that N-glycans modulate conformations of S domains, such as the immunogenic receptor binding domain (RBD). Therefore, S N-glycans play a direct role in immune response modulation. As such, N-glycan maturation changes in S due to tissue-, population-, ethnicity- , and age-specific differences in biosynthetic machinery have the potential to dramatically alter infection CoV outcomes and genetic vaccine immunogenicity. Yet little is known about the atomic-level consequences of N- glycan maturation on S structure-function. This is mainly due to the inability to arrest S in various stages of trafficking and N-glycan maturation. In this grant application, we will use an innovative new methodology to control S trafficking. Purified samples of these novel S constructs will be structurally characterized using latest cryoEM and computational tools and assayed for interactions with highly potent conformation-sensitive antibodies. This will generate unprecedented and the first insights into structural modulation of S conformations and epitopes by N-glycan maturation. Collectively, these investigations will be highly significant in providing fundamental insights into secretory trafficking and the role of bidirectional trafficking of S in modulating N-glycan maturation and RBD conformations. These data will open avenues for the design of a new generation of S-based vaccines with improved immunogenicity. In the future, the insights from this research will serve as a platform to inform the design of vaccines against enveloped viruses that pose global health challenges such as HIV and influenza, which utilize the host cell ER-Golgi-PM secretory pathway to acquire immunity evading glycans.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15190", "attributes": { "award_id": "1R21OD037879-01", "title": "The Unilateral Mosaic (UMos): Novel tools to compartmentalize pathology and trace cellular interactions in mouse models of human disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 20539, "first_name": "Sige", "last_name": "Zou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-01", "end_date": "2026-06-30", "award_amount": 235500, "principal_investigator": { "id": 22699, "first_name": "David W", "last_name": "Gludish", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 279, "ror": "https://ror.org/05bnh6r87", "name": "Cornell University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 279, "ror": "https://ror.org/05bnh6r87", "name": "Cornell University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will credential two novel types of broadly applicable mouse models, which we will demonstrate in the lung. First, we will express genes that drive disease susceptibility on one side of the lungs only, a model we call a Unilateral Mosaic, creating disease-prone and disease resistant (internal control) lung tissue in a single animal. The lungs serve as a proof-of-concept organ, but this Unilateral Mosaic model applies to other asymmetric or paired organ systems such as the liver, and also to the limbs. The second type of engineered mouse will harbor an allele that installs permanent genetic marks within niche or neighbor cells, for in vivo cellular contact tracing in mice. Using a secreted and cell-permeant Tat-Cre protein, cells will be targeted for recombination in vitro using co-culture and media transfer experiments, and in vivo using transplantation of engineered Tat-Cre expressing cells into loxP-activated fluorescent reporter mice. There is an urgent need for mouse models that reduce animal to animal variability, and increase the in vivo resolving power for tracking cellular behavior. The models we present begin to address these challenges, and will appeal to a wide variety of investigators that employ mice to study complex human diseases. The proposed genetic tools are designed to address numerous categories of biological problems in living animals, but are not intrinsically confined to a specific disease state or organ. These studies employ the well-established Cre-LoxP system for targeted in vivo gene expression, applicable to the numerous floxed alleles in existence. This work will broadly impact the available applications for tissue- or lineage-specific expression of genes in mice, enabling investigators to track cells or induce gene expression in neighboring or transacting cells that contact driver cells of a given lineage. Specific Aim 1. Generate a Unilateral Mosaic model of disease susceptibility. a. Test whether human Ace2 excision can restrict SARS-CoV2 infection to one side of the lung. b. Determine whether excision of Cox2/Ptgs2 unilaterally in the lungs can compartmentalize metastatic disease after intravenous injection of metastatic mouse mammary cancer cells. Specific Aim 2. Test and deploy a Tat-Cre allele for in vivo lineage contact tracing We anticipate this project will yield rapid results, as we already have the ASE-Cre Unilateral Mosaic driver mice in house and have exciting preliminary data to reveal the target organs for its asymmetric expression. We have performed many SARS-CoV-2 viral challenge studies in human Ace2 knockin/knockout mice with a currently approved and active animal BSL-3 program in the lab. In addition to our experience in mouse mammary tumor models and lung developmental and cancer biology in mice, we have established collaborations to ensure the success of syngeneic mammary tumor transplant studies. For Aim 2, we already have cloned and present preliminary data to demonstrate the utility of the new Tat-Cre construct. In summary, we have the required experience and existing preliminary data and materials to bring the proposed studies to a successful completion.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15141", "attributes": { "award_id": "2423051", "title": "SBIR Phase II: Development of an End-to-End Solution for High-Volume Water Microbiological Testing", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "SBIR Phase II" ], "program_reference_codes": [], "program_officials": [ { "id": 936, "first_name": "Henry", "last_name": "Ahn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-15", "end_date": null, "award_amount": 995600, "principal_investigator": { "id": 5090, "first_name": "Abdennour", "last_name": "Abbas", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 227, "ror": "", "name": "University of Minnesota-Twin Cities", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1982, "ror": "", "name": "FRONTLINE BIOTECHNOLOGIES INC.", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to enhance public health and safety through advanced water microbiological testing technologies. This project's innovation enables the early detection of pandemics by identifying waterborne viruses such as SARS-CoV-2 which causes COVID-19, and norovirus, which is notorious for causing gastroenteritis, potentially weeks before outbreaks manifest. Such early detection is vital for policymakers, allowing more effective intervention strategies and reducing both human casualties and healthcare costs. Moreover, the technology promises to improve the safety of drinking water, particularly important as many states increasingly turn to recycling wastewater due to drought. This could decrease the incidence of waterborne illnesses, which currently affect millions and cost the U.S. healthcare system billions annually. Additionally, the innovation facilitates more accessible and efficient water testing in remote and underserved communities by reducing costs and processing times, supporting healthcare equity. Finally, this new approach not only promises to transform drinking water safety monitoring practices and wastewater-based pandemic surveillance but also drives the implementation of new water quality standards and regulatory frameworks, aligning with the Best Available Technology practices.<br/><br/>This Small Business Innovation Research (SBIR) Phase II project addresses significant gaps in water microbiological testing. Monitoring the presence of viruses such coronavirus and norovirus in water is crucial for pandemic surveillance and drinking water safety. Waterborne viruses are present in low concentrations and their detection requires the analysis of large sample volumes. However, current tools are designed for small volumes, resulting in low sensitivity and high variability in testing results. The goal of this project is to develop a comprehensive technological solution to enhance the reliability and standardization of wastewater epidemiology and drinking water testing, a pressing need identified by health agencies to improve data quality and comparability. The current effort focuses on developing a scalable platform that integrates a novel filtration cartridge and reagent kit, capable of processing up to two liters of water in less than five minutes. This capability enhances the yield and purity of viral nucleic acids and improves the detection limit by two orders of magnitude, enhancing accuracy and reducing false positives. By improving our ability to monitor pathogen spread through community water systems, this project is expected to enhance pandemic preparedness and drinking water safety and facilitate more effective public health interventions.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 2, "pages": 1442, "count": 14420 } } }