Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=2&sort=-other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=-other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=3&sort=-other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-other_investigators" }, "data": [ { "type": "Grant", "id": "15774", "attributes": { "award_id": "1R44AI191836-01", "title": "Development of a monoclonal therapy for neonatal herpes", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32845, "first_name": "JULIE", "last_name": "DYALL", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-08", "end_date": "2026-07-31", "award_amount": 248531, "principal_investigator": { "id": 32846, "first_name": "Michael H", "last_name": "Pauly", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32847, "first_name": "Kevin John", "last_name": "Whaley", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2641, "ror": "", "name": "ZABBIO, INC.", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Neonatal infections caused by herpes simplex virus 1 or 2 (HSV-1, HSV-2) result in significant morbidity and mortality. Current medical treatment of neonatal HSV infections (nHSV) is limited to small molecule antivirals such as acyclovir, but even with high dose treatment, mortality subsequent to disseminated disease remains high (30%), and central nervous system (CNS) disease is associated with ∼70% neurological morbidity and 25% mortality. Monoclonal antibodies (mAbs) offer a class of intervention that provides immediate protection and a well-established development path, with over 200 mAb products licensed by U.S. and European regulatory bodies. Passive immunization with mAbs has been shown to be effective against a wide variety of infectious agent, with mAbs against Ebola virus, SARS-CoV-2, and Respiratory Syncytial Virus (RSV) approved by the FDA. Members of the ZabBio team have previously advanced 3 mAb products to clinical trials, including one which contained the broadly neutralizing HSV mAb, HSV8, which is the focus of this product development Fast Track SBIR proposal for neonatal HSV infection. More recently, ZabBio scientists have collaborated with Drs. Margaret Ackerman and David Leib (Dartmouth) who have demonstrated the utility of HSV8 in a mouse model of nHSV. These data support the hypothesis that HSV8 may be a useful clinical intervention for nHSV in humans. Phase 1 of this proposal contains 2 aims: 1) Assess the neutralization potency of HSV8 against a panel of HSV-1 and HSV-2 isolates from neonatal herpes patients; 2) Test whether HSV8 selects for HSV-1 and HSV-2 escape mutants. These two aims will result in a rigorous Go/No decision for proceeding to Phase 2. In Phase 2, the proposal transitions to traditional product development with 3 aims: 1) Manufacture HSV8 under cGMP in the Nicotiana benthamiana based Rapid Protein Production Platform (RP3) system; 2) Submit pre-IND to FDA; 3) Perform IND-enabling pharmacology/toxicology studies. This work scope will culminate in an Investigational New Drug (IND) submission.", "keywords": [ "2019-nCoV", "Acyclovir", "Adult", "Anti-viral Agents", "Atopobium vaginae", "Biological Assay", "Central Nervous System Diseases", "Chemistry", "Clinical", "Clinical Pathways", "Clinical Treatment", "Clinical Trials", "Collaborations", "Congenital herpes simplex", "Cyclic GMP", "Data", "Development", "Disease", "Dose", "Ebola virus", "Escape Mutant", "European", "FDA approved", "Feedback", "Film", "Herpesvirus 1", "Human", "Human Herpesvirus 2", "Incubated", "Infectious Agent", "Intervention", "Investigational Drugs", "Licensing", "Medical", "Monoclonal Antibodies", "Monoclonal Antibody Therapy", "Morbidity - disease rate", "Neonatal", "Neurologic", "Nicotiana", "Passive Immunization", "Patients", "Pharmaceutical Preparations", "Pharmacology and Toxicology", "Phase", "Phase I Clinical Trials", "Predisposition", "Production", "Proteins", "Research Design", "Respiratory syncytial virus", "Rodent", "Running", "Safety", "Scientist", "Simplexvirus", "Small Business Innovation Research Grant", "System", "Techniques", "Testing", "Tissues", "Toxicokinetics", "Virus", "Work", "cross reactivity", "efficacy study", "manufacture", "member", "monoclonal antibody production", "mortality", "mouse model", "mutant", "neonatal infection", "neonatal mice", "phase 1 study", "product development", "small molecule", "trial planning", "vaginal microbicide", "virology" ], "approved": true } }, { "type": "Grant", "id": "15765", "attributes": { "award_id": "1R21HD118668-01", "title": "Effects of a natural experiment on maternal and infant health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 32834, "first_name": "JUANITA JEANNE", "last_name": "CHINN", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-01", "end_date": "2027-07-31", "award_amount": 446000, "principal_investigator": { "id": 32835, "first_name": "Tim Allen", "last_name": "Bruckner", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32836, "first_name": "Claire E", "last_name": "Margerison", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2633, "ror": "", "name": "HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Rates of adverse maternal and infant health outcomes (e.g., preterm delivery, severe maternal morbidity, and mortality) in the United States (US) substantially outpace other high-income nations and are unacceptably high among women identifying as Black, American Indian, or Alaska Native and those living in rural areas. Municipalities and states across the US have begun implementing cash transfer programs, many targeted to pregnant women or families, with the objective of improving maternal and infant health through poverty reduction. Yet, evidence about the impact of cash transfers (i.e., intentional monetary transfers to individuals or households) on maternal and infant health in the US is decidedly mixed. A temporary expansion of the US Child Tax Credit (CTC) that led to an unprecedented 35% reduction in child poverty in 2021 offers an ideal natural experiment with which to test the impact of receiving monthly cash transfers during pregnancy on maternal and infant health. Surprisingly, our own preliminary ecological study indicated that the 2021 CTC expansion preceded an unexpected increase in low birth weight (LBW) among births to women likely to have received the CTC.17 This work calls into question the straightforward assumption that cash transfers in the US (such as the CTC) would improve infant health. The overall goal of this proposal is to thus examine the impact of cash transfers during pregnancy on maternal and infant health and health disparities in the US. The specific aims of this proposal are to 1) Estimate impacts of receiving CTC monthly payments during pregnancy on maternal and infant health, and 2) Determine whether impacts of receiving CTC monthly payments during pregnancy on maternal and infant health differ by race/ethnicity, socioeconomic status, or rurality. Exploiting, as a natural experiment, the unexpected and temporary monthly CTC payments received by ~40% of pregnant women between July and December of 2021, we will construct a simulated instrument to estimate individual-level impacts of the CTC expansion during pregnancy on maternal and infant health, and we will use rigorous methods to account for other health, social, policy, and economic changes during the COVID-19 pandemic. We will use two high-quality survey and administrative datasets (i.e., US Natality data and the Pregnancy Risk Assessment Monitoring System survey) to assess maternal and infant health measures plausibly impacted by cash transfers. Our study team, with 15 years of collaboration and expertise in maternal health, impacts of cash transfers on health, and the proposed methods and datasets, is ideally poised to achieve our goal. Our proposal responds directly to an NICHD Notice of Special Interest. Achieving these aims will increase understanding of how cash transfers impact maternal and infant health and will inform development of ongoing programs and policies, including local cash transfer pilot projects and future changes to the CTC and other tax credits.", "keywords": [ "Address", "Affect", "Age", "Alaska Native", "American", "American Indian", "Birth", "Black race", "COVID-19 pandemic", "Child", "Collaborations", "Data", "Data Set", "Development", "Economics", "Eligibility Determination", "Ethnic Origin", "Ethnic Population", "Face", "Family", "Future", "Goals", "Health", "Health Benefit", "Household", "Income", "Individual", "Infant Health", "Knowledge", "Literature", "Low Birth Weight Infant", "Maternal Health", "Measures", "Mental Health", "Methods", "Monitor", "Municipalities", "National Institute of Child Health and Human Development", "Natural experiment", "Outcome", "Persons", "Pilot Projects", "Policies", "Population", "Pregnancy", "Pregnant Women", "Premature Birth", "Prenatal care", "Productivity", "Quasi-experiment", "Race", "Research", "Resources", "Risk Assessment", "Role", "Rural", "Shock", "Socioeconomic Status", "Surveys", "System", "Taxes", "Testing", "United States", "Variant", "Woman", "Work", "adverse outcome", "care utilization", "child poverty", "federal policy", "health disparity", "improved", "innovation", "instrument", "interest", "low socioeconomic status", "member", "mortality", "pandemic disease", "payment", "poverty reduction", "programs", "racial difference", "racial minority population", "rural area", "rural dwellers", "rurality", "safety net", "severe maternal morbidity", "smoking during pregnancy", "social", "socioeconomics", "theories", "unemployment insurance" ], "approved": true } }, { "type": "Grant", "id": "15764", "attributes": { "award_id": "1R21AI187979-01A1", "title": "Development of a stable mRNA prophylactic vaccine against SARS-CoV-2 omicron variant", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32831, "first_name": "JENNIFER L", "last_name": "GORDON", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-18", "end_date": "2027-07-31", "award_amount": 161500, "principal_investigator": { "id": 32832, "first_name": "Yongbin", "last_name": "Liu", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32833, "first_name": "Junhua", "last_name": "Mai", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2632, "ror": "", "name": "METHODIST HOSPITAL RESEARCH INSTITUTE", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Infectious disease remains one of the leading causes of illness and mortality worldwide. The recent coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) led to widespread illness and death, disrupting public health and economy. It has been successfully mitigated thanks to the development and global application of the novel messenger RNA (mRNA) vaccine technology. While mRNA vaccines have offered significant protection, the high mutation rate of SARS-CoV-2 necessitates ongoing development of updated vaccines to combat new variants. While mRNA vaccines have shown remarkable effectiveness against COVID-19 by stimulating both humoral and cellular immune responses, the main limitation lies in the inherent instability of mRNAs at normal conditions without protection. Therefore, current mRNA and mRNA formulations require ultralow temperatures for storage and transportation. Recognizing the instability challenge, we proposed to develop a novel “RNA-plex” technology, which uses an “carrier-base” polymer to bind to mRNA molecules, preventing them from degradation in fridge or room temperature during storage. It significantly reduces the transportation and distribution costs, and makes mRNA vaccines more accessible globally, especially in areas with limited cold chain facilities. Notably, this mRNA protection technology can universally shield various mRNAs, is compatible with multiple delivery systems, and significantly enhances mRNA translation in cells, suggesting its promising potential for diverse therapeutic and research applications. In this proposal, we will apply this mRNA stabilization technology named “RNA-plex” in the development of stable and efficient vaccines for SARS-CoV-2 prevention. Specifically, we will optimize the composition and formulation of RNA-plex to maximize its protective efficacy for SARS-CoV-2 omicron variant spike protein mRNA. Next, we will apply it in preparing prophylactic lipid nanoparticle (LNP) mRNA vaccines with high stability, enhanced antigen translation efficiency, and superior vaccination effectiveness compared to conventional approaches against emerging viral threats, using the recent SARS-CoV-2 omicron variant XBB.1.5 as a proof-of-principle model. Specific Aims: Aim 1. Stabilization of SARS-CoV-2 omicron variant mRNA using RNA-plex technology and develop an LNP mRNA vaccine. Aim 2. Evaluate the efficacy of LNP-RNA-plex vaccine in eliciting immune responses and protection against SARS-CoV-2 Omicron variant.", "keywords": [ "2019-nCoV", "Address", "Adverse effects", "Affect", "Algorithms", "Animal Model", "Antibody titer measurement", "Antigens", "Area", "Aspartate", "B-Lymphocytes", "Base Composition", "Behavior", "Binding", "Biological", "Biological Assay", "Biology", "COVID-19", "COVID-19 pandemic", "COVID-19 vaccine", "Cells", "Cessation of life", "Charge", "Circular Dichroism", "Codon Nucleotides", "Cold Chains", "Communicable Diseases", "Complex", "Cryopreservation", "Dependence", "Development", "Differential Scanning Calorimetry", "Dissociation", "Effectiveness", "Electrostatics", "Endosomes", "Ensure", "Enzyme-Linked Immunosorbent Assay", "Formulation", "Glutamates", "Goals", "Hydrogen Bonding", "Hydrolysis", "Immune response", "Immunization", "Individual", "Infrastructure", "K-18 conjugate", "Knowledge", "Length", "Logistics", "Messenger RNA", "Methods", "Modality", "Modeling", "Modification", "Mutation", "Names", "Nucleotides", "Outcome", "Performance", "Phosphorus", "Poly(A) Tail", "Polymers", "Prevention", "Preventive vaccine", "Proteins", "Public Health", "RNA", "RNA Degradation", "RNA Sequences", "RNA Stability", "RNA vaccine", "Research", "Ribonucleases", "Ribose", "Ribosomal Frameshifting", "Ribosomes", "SARS-CoV-2 B.1.1.529", "Structure", "Surface Plasmon Resonance", "System", "T cell response", "Techniques", "Technology", "Temperature", "Testing", "Therapeutic", "Toxic effect", "Transgenic Mice", "Translations", "Transportation", "Update", "Vaccination", "Vaccines", "Variant", "Viral", "Western Blotting", "base", "biodegradable polymer", "booster vaccine", "circular RNA", "cold temperature", "combat", "compare effectiveness", "cost", "design", "efficacy evaluation", "hydroxyl group", "improved", "in vivo monitoring", "innovation", "lipid nanoparticle", "mRNA delivery", "mortality", "mouse model", "novel", "nucleobase", "phrases", "preservation", "prevent", "prophylactic", "protective efficacy", "success", "therapeutic RNA", "translation assay", "vaccine access", "vaccine efficacy", "vaccine formulation", "vaccine platform" ], "approved": true } }, { "type": "Grant", "id": "15759", "attributes": { "award_id": "1R01AI175536-01A1", "title": "ACE2 immunodecoys for long-lasting immunoprophylaxis against sarbecovirus and merbecoviruses that target human ACE2", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32536, "first_name": "DIPANWITA", "last_name": "BASU", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-18", "end_date": "2029-07-31", "award_amount": 2937578, "principal_investigator": { "id": 32825, "first_name": "Samuel", "last_name": "Lai", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32826, "first_name": "RAYMOND J", "last_name": "PICKLES", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2628, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "While vaccines are readily available for SARS-CoV-2, there continues to be significant demand for prophylaxis that are potent and not at risk for viral escape to better protect vulnerable populations. In addition, there is emerging evidence that a number of bat sarbecoviruses and merbecoviruses can use human ACE2 (hACE2) as an entry receptor to infect human cells. Thus, there is also a need to advance effective immunoprophylaxis to protect against such zoonotic coronaviruses with pandemic potential. We have previously advanced an ACE2-immunodecoy as treatment for SARS-CoV-2 infections. Instead of the common approach pursued by many investigators to affinity mature ACE2 to enhance binding to SARS-CoV-2 Spike, we instead sought to optimize the linkage between the extracellular fragment of human ACE2 and IgG1-Fc (ALFc) to promote improved bivalent binding to SARS-CoV-2 Spike. Similar to other ACE2- decoys, ALFc is not susceptible to viral escape. Unlike other ACE2-decoys, the preservation of the full human ACE2 sequence means ALFc is likely active against all ACE2-targeted viruses. We have demonstrated that ALFc maintains picomolar activity (comparable to many of the previous leading monoclonal antibodies that received emergency use authorization) against all variants of SARS-CoV-2, and is highly effective in a hamster challenge model. Importantly, the ALFc has outstanding bioprocessing attributes, including stability at high concentrations and exceptional productivity using cGMP CHO production cell line. These attributes have led the U.S. Army to select ALFc to be advanced into clinical development over other ACE2 decoys; GMP materials for clinical trials and GLP tox studies are currently underway, and a Phase 1 clinical study is planned for 2H 2025. In this proposal, we build on the success of ALFc as an inhaled therapy to establish the efficacy of ALFc as a systemic immunoprophylaxis that can prevent severe pulmonary disease in vulnerable populations. Specifically, the ALFc currently in development possess wildtype IgG1-Fc. For sustained immunoprophylaxis lasting >6-9 months, it is essential to utilize Fc with enhanced affinity to FcRn, such as YTE, LS and DHS mutations. In this proposal, we will first produce and characterize ALFcYTE, ALFcLS and ALFcDHS(Aim 1). We will evaluate their activity against a panel of hACE2-targeting viruses, including emerging bat sarbecoviruses and merbecoviruses, using both pseudotyped alphavirus vectors in cell-lines (BSL-2) and infectious virus clones in well-differentiated cultures of human airway epithelial cells (BSL-3) (Aim 2). Finally, we evaluate the ability of ALFc to protect against infectious clones of SARS-CoV-2 and SHC014-CoV challenge in human ACE2 transgenic mice (Aim 3). Successful completion of these studies will likely advance an intervention for providing immunoprophylaxis against future SARS-CoV-2 variants as well as other hACE2-targeted coronaviruses with pandemic potential.", "keywords": [ "2019-nCoV", "ACE2", "Adult", "Affinity", "Allergic Reaction", "Alpha Virus", "Antibodies", "Binding", "Binding Proteins", "Biodistribution", "Biological Products", "COVID-19 pandemic", "COVID-19 treatment", "Cell Culture Techniques", "Cell Line", "Cells", "Chiroptera", "Circulation", "Clinical Research", "Clinical Trials", "Coronavirus", "Coronavirus Infections", "Cyclic GMP", "Data", "Development", "Dose", "Drug Kinetics", "Engineering", "Epithelial Cells", "Escape Mutant", "Evolution", "Excipients", "FDA Emergency Use Authorization", "Future", "Hamsters", "Human", "IgG1", "Immunocompromised Host", "Individual", "Infant", "Infection", "Inhalation", "Inhalation Therapy", "Intervention", "Length", "Link", "Literature", "Lung", "Lung Diseases", "Macaca", "Macaca mulatta", "Marketing", "Measures", "Merbecovirus", "Modeling", "Molecular Conformation", "Monoclonal Antibodies", "Mus", "Mutate", "Mutation", "Nebulizer", "Nose", "Parents", "Passive Immunization", "Phase", "Prevention", "Production", "Productivity", "Prophylactic treatment", "Proteins", "RNA vaccine", "Recording of previous events", "Research Personnel", "Risk", "SARS coronavirus", "SARS-CoV-2 infection", "SARS-CoV-2 spike protein", "SARS-CoV-2 variant", "Sarbecovirus", "Serum", "Temperature", "Testing", "Therapeutic", "Transgenic Mice", "Transgenic Organisms", "Vaccines", "Variant", "Viral", "Virus", "Virus Diseases", "Vulnerable Populations", "Work", "Zoonoses", "aerosolized", "airway epithelium", "bioprocess", "clinical development", "clinical material", "design", "extracellular", "flexibility", "immunoprophylaxis", "improved", "in vitro Model", "in vivo", "manufacture", "melting", "mutant", "neonatal Fc receptor", "pandemic coronavirus", "pandemic potential", "preservation", "prevent", "pulmonary", "receptor", "receptor binding", "success", "vector", "zoonotic coronavirus" ], "approved": true } }, { "type": "Grant", "id": "15757", "attributes": { "award_id": "1R01HD114714-01A1", "title": "Bone age determination for the 21st Century: Using AI to broaden and diversify a 60-year-old gold standard and overcome reader bias", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 21091, "first_name": "KAREN", "last_name": "WINER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-01", "end_date": "2030-04-30", "award_amount": 448280, "principal_investigator": { "id": 32820, "first_name": "Anouck", "last_name": "Girard", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32821, "first_name": "JOSEPHINE Z", "last_name": "KASA-VUBU", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32822, "first_name": "Niko Albert", "last_name": "Kaciroti", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2626, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract Bone age (BA) is a measure of maturation of a child’s skeleton, and, as such, a key clinical indicator of growth used by pediatricians and pediatric endocrinologists. As a person’s body ages, from birth through childhood, puberty, and adulthood, the size and shape of the bones of the skeleton change. Growth plates, initially wide open, fuse progressively in childhood. The BA is meant to be the “average” age at which the skeleton reaches a certain degree of maturation. In combination with other measures, it can be used to predict future adult height and detect possible growth disorders or abnormal pubertal maturation. The estimation of BA with a radiological image of the left hand and wrist describes the degree of maturation of a child’s skeleton. The most commonly available standards for the BA estimation, such as the Greulich and Pyle (G&P) Atlas (1959) and the Tanner-Whitehouse method, involve visual inspection of X-ray images of the person’s left hand and wrist, followed by its comparison with the set of reference images. This manual inspection is not only time- consuming, but subjective, and the estimation among radiologists may vary depending upon experience / expertise. Moreover, the data collected in these approaches is outdated: the current population of the United States has been much reshaped in the last 60 years, due to a larger number of children of international ancestry and a nutritional environment, particularly during the COVID pandemic, that has resulted in an obesity pandemic that affects the growth and rate of physical maturation of children. Thus, there is a need to renovate these bone age standards such that the reference is representative of the current population and develop an AI-assisted system for the accurate prediction of bone age. Moreover, the research team for the proposed project will develop an adjustment factor to incorporate the BMI Z-score for more clinical relevance of the AI- assisted outcome. The proposed technical approach is three-pronged. Specific Aim 1 is to establish a database for BA assessment in children that addresses racial and ethnic disparities and reduces spacing between available standards. Specific Aim 2 is to develop and validate an AI-assisted classification system for BA readings from the X-ray images. Finally, Specific Aim 3 is to enhance BA determination by an adjustment factor reflecting the impact of BMI Z-score on skeletal maturation. In support of all three aims, a web designer will build and deploy a web application capable of incorporating the AI algorithm for the adjusted Bone Age determination with qualitative data provided by users.", "keywords": [ "Address", "Adoption", "Adrenal Gland Diseases", "Adult", "Affect", "Age", "Anxiety", "Artificial Intelligence enhanced", "Atlases", "Automobile Driving", "Birth", "Black race", "Body mass index", "COVID-19 pandemic", "Child", "Child Health", "Childhood", "Chronology", "Classification", "Clinical", "Computerized Medical Record", "Consultations", "Consumption", "Data", "Databases", "Decision Making", "Elements", "Endocrinologist", "Environment", "Epiphysial cartilage", "Ethnic Origin", "European ancestry", "Evaluation", "FDA approved", "Fostering", "Future", "Growth", "Growth Disorders", "Hand", "Health", "Health Care Costs", "Height", "Hormonal", "Image", "International", "Internet", "Left", "Link", "Machine Learning", "Manuals", "Marketing", "Measures", "Medical", "Methods", "Michigan", "North America", "Nutritional", "Obesity", "Obesity Epidemic", "Ohio", "Outcome", "Pattern", "Performance", "Persons", "Population", "Precocious Puberty", "Predisposition", "Procedures", "Puberty", "Race", "Radiology Specialty", "Reader", "Reading", "Research", "Roentgen Rays", "Sampling", "Selection Bias", "Shapes", "Skeletal bone", "Skeleton", "Societies", "Somatotropin", "Specialist", "Standardization", "System", "Technology", "Testing", "Time", "Underweight", "United States", "Universities", "Variant", "Visual", "Weight", "Wrist", "X-Ray Medical Imaging", "artificial intelligence algorithm", "bone age", "boys", "care providers", "clinical practice", "clinically relevant", "cost", "database expansion", "ethnic disparity", "experience", "girls", "health disparity", "infancy", "innovation", "novel", "novel strategies", "obesity in children", "pandemic disease", "pediatrician", "racial disparity", "racial diversity", "radiological imaging", "radiologist", "skeletal maturation", "stem", "tool", "web app", "young adult" ], "approved": true } }, { "type": "Grant", "id": "15757", "attributes": { "award_id": "1R01HD114714-01A1", "title": "Bone age determination for the 21st Century: Using AI to broaden and diversify a 60-year-old gold standard and overcome reader bias", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 21091, "first_name": "KAREN", "last_name": "WINER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-01", "end_date": "2030-04-30", "award_amount": 448280, "principal_investigator": { "id": 32820, "first_name": "Anouck", "last_name": "Girard", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32821, "first_name": "JOSEPHINE Z", "last_name": "KASA-VUBU", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32822, "first_name": "Niko Albert", "last_name": "Kaciroti", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2626, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract Bone age (BA) is a measure of maturation of a child’s skeleton, and, as such, a key clinical indicator of growth used by pediatricians and pediatric endocrinologists. As a person’s body ages, from birth through childhood, puberty, and adulthood, the size and shape of the bones of the skeleton change. Growth plates, initially wide open, fuse progressively in childhood. The BA is meant to be the “average” age at which the skeleton reaches a certain degree of maturation. In combination with other measures, it can be used to predict future adult height and detect possible growth disorders or abnormal pubertal maturation. The estimation of BA with a radiological image of the left hand and wrist describes the degree of maturation of a child’s skeleton. The most commonly available standards for the BA estimation, such as the Greulich and Pyle (G&P) Atlas (1959) and the Tanner-Whitehouse method, involve visual inspection of X-ray images of the person’s left hand and wrist, followed by its comparison with the set of reference images. This manual inspection is not only time- consuming, but subjective, and the estimation among radiologists may vary depending upon experience / expertise. Moreover, the data collected in these approaches is outdated: the current population of the United States has been much reshaped in the last 60 years, due to a larger number of children of international ancestry and a nutritional environment, particularly during the COVID pandemic, that has resulted in an obesity pandemic that affects the growth and rate of physical maturation of children. Thus, there is a need to renovate these bone age standards such that the reference is representative of the current population and develop an AI-assisted system for the accurate prediction of bone age. Moreover, the research team for the proposed project will develop an adjustment factor to incorporate the BMI Z-score for more clinical relevance of the AI- assisted outcome. The proposed technical approach is three-pronged. Specific Aim 1 is to establish a database for BA assessment in children that addresses racial and ethnic disparities and reduces spacing between available standards. Specific Aim 2 is to develop and validate an AI-assisted classification system for BA readings from the X-ray images. Finally, Specific Aim 3 is to enhance BA determination by an adjustment factor reflecting the impact of BMI Z-score on skeletal maturation. In support of all three aims, a web designer will build and deploy a web application capable of incorporating the AI algorithm for the adjusted Bone Age determination with qualitative data provided by users.", "keywords": [ "Address", "Adoption", "Adrenal Gland Diseases", "Adult", "Affect", "Age", "Anxiety", "Artificial Intelligence enhanced", "Atlases", "Automobile Driving", "Birth", "Black race", "Body mass index", "COVID-19 pandemic", "Child", "Child Health", "Childhood", "Chronology", "Classification", "Clinical", "Computerized Medical Record", "Consultations", "Consumption", "Data", "Databases", "Decision Making", "Elements", "Endocrinologist", "Environment", "Epiphysial cartilage", "Ethnic Origin", "European ancestry", "Evaluation", "FDA approved", "Fostering", "Future", "Growth", "Growth Disorders", "Hand", "Health", "Health Care Costs", "Height", "Hormonal", "Image", "International", "Internet", "Left", "Link", "Machine Learning", "Manuals", "Marketing", "Measures", "Medical", "Methods", "Michigan", "North America", "Nutritional", "Obesity", "Obesity Epidemic", "Ohio", "Outcome", "Pattern", "Performance", "Persons", "Population", "Precocious Puberty", "Predisposition", "Procedures", "Puberty", "Race", "Radiology Specialty", "Reader", "Reading", "Research", "Roentgen Rays", "Sampling", "Selection Bias", "Shapes", "Skeletal bone", "Skeleton", "Societies", "Somatotropin", "Specialist", "Standardization", "System", "Technology", "Testing", "Time", "Underweight", "United States", "Universities", "Variant", "Visual", "Weight", "Wrist", "X-Ray Medical Imaging", "artificial intelligence algorithm", "bone age", "boys", "care providers", "clinical practice", "clinically relevant", "cost", "database expansion", "ethnic disparity", "experience", "girls", "health disparity", "infancy", "innovation", "novel", "novel strategies", "obesity in children", "pandemic disease", "pediatrician", "racial disparity", "racial diversity", "radiological imaging", "radiologist", "skeletal maturation", "stem", "tool", "web app", "young adult" ], "approved": true } }, { "type": "Grant", "id": "15753", "attributes": { "award_id": "1R21ES038077-01", "title": "Project Firestorm: Assessing Respiratory and Mental Health Impacts of Wildland-Urban Interface Fires and Long-Term Toxic Exposures", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 32812, "first_name": "ASHLINN KO", "last_name": "QUINN", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-25", "end_date": "2027-08-24", "award_amount": 456500, "principal_investigator": { "id": 32813, "first_name": "FRANK D.", "last_name": "GILLILAND", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32814, "first_name": "Daniel", "last_name": "Soto", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32815, "first_name": "Jennifer Beth", "last_name": "Unger", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2622, "ror": "", "name": "UNIVERSITY OF SOUTHERN CALIFORNIA", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT The Los Angeles firestorms in January 2025 burned over 50,000 acres, destroyed over 16,000 homes and other structures, and displaced over 150,000 Los Angeles County residents. Most importantly, the fires have significantly impacted air quality across the Los Angeles Basin. The fires released high levels of fine particulate matter, VOCs, CO, NOx, and ozone precursors, exacerbating respiratory and cardiovascular conditions for those throughout Los Angeles. These findings stress the need to study long-term health impacts of wildland- urban interface (WUI) wildfire smoke. The acute and longer-term health effects of exposures from these catastrophic wildfires have yet to be defined. A better understanding of WUI) fire-related exposures and the health impacts is an urgent public health priority for Los Angeles. We will collect biological samples from affected individuals and analyze home dust, surface contaminants and outdoor soil and ash over time. After a wildfire it is critical to assess exposure levels and characterize the composition of toxins before home clean-up and environmental factors, such as wind and rain, alter its distribution or concentrations. We propose to conduct Project Firestorm, a rapid study to quantify the health effects of the wildfires. We will leverage an existing cohort of over 9,000 USC faculty, staff, and students who participated in a longitudinal COVID-19 study in 2021-2022. These participants, most of whom live in or around Los Angeles, have completed surveys about their physical and mental health and sociodemographics, providing an essential baseline assessment. The participants have signed consent forms giving their permission to be recontacted for future studies, enabling us to launch the study quickly without extensive recruitment time. We will recontact these participants and invite them to complete a survey about the effects of the fires on physical, mental, and financial health over the next year. From those who complete the survey (N=approximately 3000), we will recruit and collect more detailed data from a sample of 200 participants--100 who lived near the fires (fire-adjacent) and 100 who live over 15 miles away from the burn site (fire-distant). These participants will provide health outcome data on respiratory and other key outcomes, hair samples, wear silicone bracelets for VOC measurements, and samples of their house dust, surface wipes and yard soil for analysis, in February-March 2025 and again in February-March 2026. We will analyze (1) differences between fire-adjacent and fire-distant participants at baseline, and (2) change over a one-year period among fire-affected households and more distant households. Findings will guide public health interventions, long-term remediation efforts, and strategies to mitigate the WUI fires’ health impacts.", "keywords": [ "Acute", "Adult", "Affect", "Air", "Anxiety", "Area", "Aromatic Polycyclic Hydrocarbons", "Arsenic", "Authorization documentation", "Biological", "Burn injury", "COVID-19", "Cadmium", "Carbon Black", "Carbon Monoxide", "Cardiovascular system", "Characteristics", "Chemical Burns", "Communities", "Consent", "Consent Forms", "Consumption", "County", "Data", "Dioxins", "Disasters", "Distant", "District of Columbia", "Dose", "Environmental Risk Factor", "Environmental Wind", "Evaluation", "Event", "Exposure to", "Faculty", "Financial Hardship", "Fire - disasters", "Flame Retardants", "Funding", "Future", "Hair", "Health", "High Prevalence", "Home", "House Dust", "Household", "Individual", "Intervention", "Investigation", "Lead", "Lead levels", "Longitudinal Studies", "Los Angeles", "Measurement", "Measures", "Mental Depression", "Mental Health", "Mercury", "Metals", "National Institute of Environmental Health Sciences", "Nitrogen Oxides", "Outcome", "Ozone", "Participant", "Particulate Matter", "Pattern", "PhenX Toolkit", "Physical assessment", "Policies", "Polychlorinated Biphenyls", "Positioning Attribute", "Post-Traumatic Stress Disorders", "Protocols documentation", "Psyche structure", "Public Health", "Rain", "Readiness", "Recontacts", "Reporting", "Research", "Respiratory Signs and Symptoms", "Risk", "Sampling", "Silicones", "Site", "Smoke", "Soil", "Standardization", "Stress", "Structure", "Students", "Surface", "Surveys", "Testing", "Time", "Toxicant exposure", "Toxin", "Wildfire", "Wrist", "air monitoring", "coarse particles", "cohort", "design", "exposed human population", "fine particles", "health data", "improved", "persistent organic pollutants", "phthalates", "physical conditioning", "physical symptom", "pollutant", "psychological symptom", "public health intervention", "public health priorities", "recruit", "remediation", "respiratory", "respiratory health", "sociodemographics", "tool", "toxic metal", "volatile organic compound", "wristband" ], "approved": true } }, { "type": "Grant", "id": "15753", "attributes": { "award_id": "1R21ES038077-01", "title": "Project Firestorm: Assessing Respiratory and Mental Health Impacts of Wildland-Urban Interface Fires and Long-Term Toxic Exposures", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 32812, "first_name": "ASHLINN KO", "last_name": "QUINN", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-25", "end_date": "2027-08-24", "award_amount": 456500, "principal_investigator": { "id": 32813, "first_name": "FRANK D.", "last_name": "GILLILAND", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32814, "first_name": "Daniel", "last_name": "Soto", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32815, "first_name": "Jennifer Beth", "last_name": "Unger", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2622, "ror": "", "name": "UNIVERSITY OF SOUTHERN CALIFORNIA", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT The Los Angeles firestorms in January 2025 burned over 50,000 acres, destroyed over 16,000 homes and other structures, and displaced over 150,000 Los Angeles County residents. Most importantly, the fires have significantly impacted air quality across the Los Angeles Basin. The fires released high levels of fine particulate matter, VOCs, CO, NOx, and ozone precursors, exacerbating respiratory and cardiovascular conditions for those throughout Los Angeles. These findings stress the need to study long-term health impacts of wildland- urban interface (WUI) wildfire smoke. The acute and longer-term health effects of exposures from these catastrophic wildfires have yet to be defined. A better understanding of WUI) fire-related exposures and the health impacts is an urgent public health priority for Los Angeles. We will collect biological samples from affected individuals and analyze home dust, surface contaminants and outdoor soil and ash over time. After a wildfire it is critical to assess exposure levels and characterize the composition of toxins before home clean-up and environmental factors, such as wind and rain, alter its distribution or concentrations. We propose to conduct Project Firestorm, a rapid study to quantify the health effects of the wildfires. We will leverage an existing cohort of over 9,000 USC faculty, staff, and students who participated in a longitudinal COVID-19 study in 2021-2022. These participants, most of whom live in or around Los Angeles, have completed surveys about their physical and mental health and sociodemographics, providing an essential baseline assessment. The participants have signed consent forms giving their permission to be recontacted for future studies, enabling us to launch the study quickly without extensive recruitment time. We will recontact these participants and invite them to complete a survey about the effects of the fires on physical, mental, and financial health over the next year. From those who complete the survey (N=approximately 3000), we will recruit and collect more detailed data from a sample of 200 participants--100 who lived near the fires (fire-adjacent) and 100 who live over 15 miles away from the burn site (fire-distant). These participants will provide health outcome data on respiratory and other key outcomes, hair samples, wear silicone bracelets for VOC measurements, and samples of their house dust, surface wipes and yard soil for analysis, in February-March 2025 and again in February-March 2026. We will analyze (1) differences between fire-adjacent and fire-distant participants at baseline, and (2) change over a one-year period among fire-affected households and more distant households. Findings will guide public health interventions, long-term remediation efforts, and strategies to mitigate the WUI fires’ health impacts.", "keywords": [ "Acute", "Adult", "Affect", "Air", "Anxiety", "Area", "Aromatic Polycyclic Hydrocarbons", "Arsenic", "Authorization documentation", "Biological", "Burn injury", "COVID-19", "Cadmium", "Carbon Black", "Carbon Monoxide", "Cardiovascular system", "Characteristics", "Chemical Burns", "Communities", "Consent", "Consent Forms", "Consumption", "County", "Data", "Dioxins", "Disasters", "Distant", "District of Columbia", "Dose", "Environmental Risk Factor", "Environmental Wind", "Evaluation", "Event", "Exposure to", "Faculty", "Financial Hardship", "Fire - disasters", "Flame Retardants", "Funding", "Future", "Hair", "Health", "High Prevalence", "Home", "House Dust", "Household", "Individual", "Intervention", "Investigation", "Lead", "Lead levels", "Longitudinal Studies", "Los Angeles", "Measurement", "Measures", "Mental Depression", "Mental Health", "Mercury", "Metals", "National Institute of Environmental Health Sciences", "Nitrogen Oxides", "Outcome", "Ozone", "Participant", "Particulate Matter", "Pattern", "PhenX Toolkit", "Physical assessment", "Policies", "Polychlorinated Biphenyls", "Positioning Attribute", "Post-Traumatic Stress Disorders", "Protocols documentation", "Psyche structure", "Public Health", "Rain", "Readiness", "Recontacts", "Reporting", "Research", "Respiratory Signs and Symptoms", "Risk", "Sampling", "Silicones", "Site", "Smoke", "Soil", "Standardization", "Stress", "Structure", "Students", "Surface", "Surveys", "Testing", "Time", "Toxicant exposure", "Toxin", "Wildfire", "Wrist", "air monitoring", "coarse particles", "cohort", "design", "exposed human population", "fine particles", "health data", "improved", "persistent organic pollutants", "phthalates", "physical conditioning", "physical symptom", "pollutant", "psychological symptom", "public health intervention", "public health priorities", "recruit", "remediation", "respiratory", "respiratory health", "sociodemographics", "tool", "toxic metal", "volatile organic compound", "wristband" ], "approved": true } }, { "type": "Grant", "id": "15739", "attributes": { "award_id": "1RF1NS144213-01", "title": "SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 32579, "first_name": "WILLIAM PATRICK", "last_name": "DALEY", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-15", "end_date": "2029-07-31", "award_amount": 3039032, "principal_investigator": { "id": 8182, "first_name": "Ananth V", "last_name": "Annapragada", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 566, "ror": "https://ror.org/02pttbw34", "name": "Baylor College of Medicine", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 7071, "first_name": "Shannon", "last_name": "Ronca", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32793, "first_name": "Andrew Arun", "last_name": "Badachhape", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32794, "first_name": "Parag", "last_name": "Parekh", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2610, "ror": "", "name": "BAYLOR COLLEGE OF MEDICINE", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "The uncertain e,ology of Alzheimer’s disease poses significant obstacles to the development of both therapeu,c and preven,on strategies. At the root of this quandary is the fact that familial disease accounts for a very small frac,on of cases, with the vast majority remaining gene,cally sporadic. The most widely known risk factor, the ApoE4 allele of the gene coding for apolipoprotein E, has been iden,fied, but mechanis,c ,es to disease development are s,ll emerging. Neuroinflamma,on has long been suspected as a contribu,ng factor, and regular exercise documented as a mi,ga,ng factor, with theories to explain their effects being posed, but again with liGle mechanis,c proof. A picture of a very complex process of ini,a,on and progression of Alzheimers disease and related demen,as (AD/RD) including Pick’s disease, fronto-temporal demen,a (FTD) and other tauopathies, is slowly emerging. A key factor in the e,ology of AD/RD that repeatedly crops up is viral infec,on. COVID-19 has brought new aGen,on to this factor, with the observa,on that a frac,on of those infected experience “brain-fog”, a catch-all term that includes cogni,ve dysfunc,on, memory dysfunc,on and mental fa,gue, marked by impaired ability to perform mental tasks compared to before the infec,on. Several factors however, complicate an understanding of the effect of COVID-19 on AD/RD and cons%tute the driving ques%ons for this proposal: These include (1) What are the rela,ve contribu,ons of gene,c risk factors and COVID-19 on ini,a,on and progression of AD/RD? (2) What are the effects of SARS-CoV-2 variants: ex,nct strains e.g. Wuhan, alpha, delta vs. current strains e.g. omicron and its lineage, and their sequen,al infec,on on AD/RD ini,a,on and progression? (3) What are the effects of prior infec,ons with other highly prevalent viruses e.g. HSV-1 on the ini,a,on and progression of AD/RD by SARS-CoV-2? Successful comple,on of this work will probe the rela,onship between COVID-19 and neurodegenera,on, while yielding deep mechanis,c insights into the role of SARS-CoV-2 in combina,on with HSV-1 in triggering/accelera,ng an AD phenotype and focus a search for therapeu,c targets to counteract AD ini,a,on/accelera,on/progression.", "keywords": [ "2019-nCoV", "Acceleration", "Acids", "Alleles", "Alzheimer's Disease", "Alzheimer's disease model", "Alzheimer's disease pathology", "Alzheimer's disease related dementia", "Amyloid", "Amyloid beta-Protein Precursor", "Apolipoprotein E", "Automobile Driving", "COVID-19", "COVID-19 impact", "Code", "Common Cold", "Complex", "Coronavirus", "Coupled", "Development", "Disease", "Exercise", "Familial disease", "Genes", "Herpesvirus 1", "Histopathology", "Image", "Impairment", "Inflammatory", "Interferons", "Interleukin-1", "Interleukin-6", "Link", "MAPT gene", "Magnetic Resonance Imaging", "Measurement", "Measures", "Memory", "Memory Loss", "Metabolism", "Methodology", "Methods", "Modeling", "National Institute of Neurological Disorders and Stroke", "Neurofibrillary Tangles", "Pathology", "Pathway interactions", "Phenotype", "Pick Disease of the Brain", "Process", "Psyche structure", "Recording of previous events", "Reporting", "Risk", "Risk Factors", "Role", "SARS-CoV-2 B.1.617.2", "SARS-CoV-2 variant", "Severity of illness", "Signal Transduction", "Study models", "Tauopathies", "Testing", "Transgenic Mice", "Viral", "Virus", "Work", "apolipoprotein E-4", "brain fog", "cytokine", "disease model", "experience", "human coronavirus", "hyperphosphorylated tau", "in vivo imaging", "insight", "mouse model", "neuropathology", "novel", "post-COVID-19", "presenilin-1", "response", "tau Proteins", "theories", "transcriptomics" ], "approved": true } }, { "type": "Grant", "id": "15739", "attributes": { "award_id": "1RF1NS144213-01", "title": "SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 32579, "first_name": "WILLIAM PATRICK", "last_name": "DALEY", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-15", "end_date": "2029-07-31", "award_amount": 3039032, "principal_investigator": { "id": 8182, "first_name": "Ananth V", "last_name": "Annapragada", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 566, "ror": "https://ror.org/02pttbw34", "name": "Baylor College of Medicine", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 7071, "first_name": "Shannon", "last_name": "Ronca", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32793, "first_name": "Andrew Arun", "last_name": "Badachhape", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32794, "first_name": "Parag", "last_name": "Parekh", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2610, "ror": "", "name": "BAYLOR COLLEGE OF MEDICINE", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "The uncertain e,ology of Alzheimer’s disease poses significant obstacles to the development of both therapeu,c and preven,on strategies. At the root of this quandary is the fact that familial disease accounts for a very small frac,on of cases, with the vast majority remaining gene,cally sporadic. The most widely known risk factor, the ApoE4 allele of the gene coding for apolipoprotein E, has been iden,fied, but mechanis,c ,es to disease development are s,ll emerging. Neuroinflamma,on has long been suspected as a contribu,ng factor, and regular exercise documented as a mi,ga,ng factor, with theories to explain their effects being posed, but again with liGle mechanis,c proof. A picture of a very complex process of ini,a,on and progression of Alzheimers disease and related demen,as (AD/RD) including Pick’s disease, fronto-temporal demen,a (FTD) and other tauopathies, is slowly emerging. A key factor in the e,ology of AD/RD that repeatedly crops up is viral infec,on. COVID-19 has brought new aGen,on to this factor, with the observa,on that a frac,on of those infected experience “brain-fog”, a catch-all term that includes cogni,ve dysfunc,on, memory dysfunc,on and mental fa,gue, marked by impaired ability to perform mental tasks compared to before the infec,on. Several factors however, complicate an understanding of the effect of COVID-19 on AD/RD and cons%tute the driving ques%ons for this proposal: These include (1) What are the rela,ve contribu,ons of gene,c risk factors and COVID-19 on ini,a,on and progression of AD/RD? (2) What are the effects of SARS-CoV-2 variants: ex,nct strains e.g. Wuhan, alpha, delta vs. current strains e.g. omicron and its lineage, and their sequen,al infec,on on AD/RD ini,a,on and progression? (3) What are the effects of prior infec,ons with other highly prevalent viruses e.g. HSV-1 on the ini,a,on and progression of AD/RD by SARS-CoV-2? Successful comple,on of this work will probe the rela,onship between COVID-19 and neurodegenera,on, while yielding deep mechanis,c insights into the role of SARS-CoV-2 in combina,on with HSV-1 in triggering/accelera,ng an AD phenotype and focus a search for therapeu,c targets to counteract AD ini,a,on/accelera,on/progression.", "keywords": [ "2019-nCoV", "Acceleration", "Acids", "Alleles", "Alzheimer's Disease", "Alzheimer's disease model", "Alzheimer's disease pathology", "Alzheimer's disease related dementia", "Amyloid", "Amyloid beta-Protein Precursor", "Apolipoprotein E", "Automobile Driving", "COVID-19", "COVID-19 impact", "Code", "Common Cold", "Complex", "Coronavirus", "Coupled", "Development", "Disease", "Exercise", "Familial disease", "Genes", "Herpesvirus 1", "Histopathology", "Image", "Impairment", "Inflammatory", "Interferons", "Interleukin-1", "Interleukin-6", "Link", "MAPT gene", "Magnetic Resonance Imaging", "Measurement", "Measures", "Memory", "Memory Loss", "Metabolism", "Methodology", "Methods", "Modeling", "National Institute of Neurological Disorders and Stroke", "Neurofibrillary Tangles", "Pathology", "Pathway interactions", "Phenotype", "Pick Disease of the Brain", "Process", "Psyche structure", "Recording of previous events", "Reporting", "Risk", "Risk Factors", "Role", "SARS-CoV-2 B.1.617.2", "SARS-CoV-2 variant", "Severity of illness", "Signal Transduction", "Study models", "Tauopathies", "Testing", "Transgenic Mice", "Viral", "Virus", "Work", "apolipoprotein E-4", "brain fog", "cytokine", "disease model", "experience", "human coronavirus", "hyperphosphorylated tau", "in vivo imaging", "insight", "mouse model", "neuropathology", "novel", "post-COVID-19", "presenilin-1", "response", "tau Proteins", "theories", "transcriptomics" ], "approved": true } } ], "meta": { "pagination": { "page": 2, "pages": 1405, "count": 14046 } } }