Represents Grant table in the DB

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                "award_id": "1R01HD110844-01",
                "title": "\"Chanjo Kwa Wakati\" - Leveraging community health workers and a responsive digital health system to improve vaccination coverage and timeliness in rural settings",
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                "start_date": "2022-09-18",
                "end_date": "2027-08-31",
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                    "first_name": "Esther Stanslaus",
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                    "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA",
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                "abstract": "Ensuring equitable vaccinations is critical for protecting all children against preventable and potentially dangerous infections such as polio, diphtheria, and measles. Yet, numerous studies have highlighted low vaccination coverage and timeliness, particularly among children from resource-limited settings. For example, in Tanzania, only 68% of children receive all basic vaccines that are recommended in the first year of life. Reasons for vaccination inequities are multifaceted; they include low caregiver knowledge about vaccines, and challenges with health service delivery and access. Health service interruptions during the global COVID-19 pandemic have further restricted opportunities for caregiver education, impacted vaccine access, and exacerbated vaccination inequities. Approaches that optimally utilize limited health workforce capacity and rapidly evolving digital health capacity for remote healthcare in resource-limited settings hold great potential for mitigating childhood vaccination inequities. We recently completed (1) a Fogarty-funded study (R21TW010262) that demonstrated the feasibility and efficacy of mobile phone-based reminders and conditional financial incentives for improving the coverage and timeliness of childhood vaccinations, and (2) a community health worker (CHW) intervention that was shown to be acceptable for mitigating caregiver knowledge gaps about childhood vaccines. Building on this prior work and with support from Tanzania’s National Immunization and Vaccine Development program, we propose to evaluate an integrated, community-based, digital intervention for promoting equity in childhood vaccinations. The outreach and educational intervention, called ”Chanjo Kwa Wakati” (“timely vaccination”), is targeted toward recent mothers and comprises a combination of CHW outreach and low-cost digital strategies (autonomous mobile phone-based vaccination promotion messages, reminders, stockout notifications, and incentive offers for timely vaccinations). In Aim 1, we will evaluate the effectiveness of Chanjo Kwa Wakati in promoting the coverage and timeliness of childhood vaccinations in a Type I effectiveness implementation hybrid trial. The trial will involve the staggered implementation of the intervention across catchment areas of 40 rural health facilities in two predominantly rural regions of Tanzania with large numbers of un- or under-vaccinated children. Vaccination outcomes will be analyzed for children born to 1200 women participating in the trial. In Aim 2, we will evaluate implementation factors associated with variations in intervention effectiveness, analyze the cost effectiveness of the intervention, and develop an implementation blueprint to guide scale-up to other settings. In Aim 3, we will evaluate the feasibility and potential efficacy of a machine learning approach for proactively identifying children at risk of non- or delayed vaccinations and validate predictive models using vaccination data gathered in Aim 1. Study findings will inform future implementations and scale up of Chanjo Kwa Wakati, including potential interventions to improve vaccination equity for children living in rural, resource- limited, or underserved communities in the United States.",
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                "title": "\"Blueprint of Life\" Genomic Literacy Tool: An interactive to enhance genetic and genomic understanding with middle/high school students and their teachers through personal genetics and human disease",
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                            "name": "D'VINCI INTERACTIVE, INC.",
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                "abstract": "The increasing prevalence of genetics and genomics information in modern life calls for an equally relevant and engaging solution to teach the next generation. Additionally, educational interventions that help close the participation and achievement gap of underrepresented demographic groups in STEM are sorely needed. In this NIGMS Phase II SBIR project, d’Vinci Interactive, in collaboration with The Jackson Laboratory, proposes to develop and evaluate a full-function prototype of the “Blueprint of Life” online educational solution, which is aimed at embedding genomics into middle school and high school classrooms. The solution will feature an expanded, NGSS-aligned supplemental curriculum that teaches key concepts around molecular genetics of personalized medicine, use of bioinformatics tools, the viral genome (particularly with regard to the COVID-19 pandemic), careers in genetics science, and the ethics of genetics research. The curriculum will be delivered via an online student learning portal designed to provide learning experiences that are engaging, inspirational, accessible, inclusive, and relevant to students’ lives, with features such as an immersive 3D/VR genome exploration module and an immersive Virtual Laboratory environment (which together represent the core of the project’s technical innovation), creative content that appeals to underrepresented demographic groups, a Spanish-language curriculum version, and adaptive learning technology. Educators will have access to a Learning Management System, online classroom tools that are easy to implement both virtually and in-class, and an Administrative Dashboard for real-time school and school-district level reporting on student learning progress. The aims for this Phase II project are to show that the solution delivers the following learner benefits: (1) effective mastery of the fundamentals of genomics/genetics and personalized medicine, (2) effective understanding of the ethical and healthcare implications of genetics/genomics, (3) motivational impact on students, by promoting interest in genomics/STEM education and careers, (4) strong learning and motivational impact on underrepresented demographic groups. WestEd, will conduct To verify the attainment of these aims, the external research and evaluation partner, a Randomized Controlled Trial (with 750 9th grade students from classrooms with high populations of underserved students) on the fully developed educational solution. Aims 1-3 are supported if students in the treatment group show a pre- versus post-assessment performance improvement (measured in terms of information retention (Aim 1), attitudes towards the practical use of science (Aim 2), and interest in pursuing additional genomics/STEM education and a genomics/STEM career (Aim 3)) that is statistically larger than the improvements observed in the control group. Aim 4 is supported if performance in the treatment group is uncorrelated with demographic factors (i.e. males vs. females and minority vs. non-minority students). Overall, the engaging and inspirational learning solution proposed in this project will help better prepare tomorrow’s healthcare consumers and scientists and promote greater diversity in STEM education and practice.",
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                "abstract": "The increasing prevalence of genetics and genomics information in modern life calls for an equally relevant and engaging solution to teach the next generation. Additionally, educational interventions that help close the participation and achievement gap of underrepresented demographic groups in STEM are sorely needed. In this NIGMS Phase II SBIR project, d’Vinci Interactive, in collaboration with The Jackson Laboratory, proposes to develop and evaluate a full-function prototype of the “Blueprint of Life” online educational solution, which is aimed at embedding genomics into middle school and high school classrooms. The solution will feature an expanded, NGSS-aligned supplemental curriculum that teaches key concepts around molecular genetics of personalized medicine, use of bioinformatics tools, the viral genome (particularly with regard to the COVID-19 pandemic), careers in genetics science, and the ethics of genetics research. The curriculum will be delivered via an online student learning portal designed to provide learning experiences that are engaging, inspirational, accessible, inclusive, and relevant to students’ lives, with features such as an immersive 3D/VR genome exploration module and an immersive Virtual Laboratory environment (which together represent the core of the project’s technical innovation), creative content that appeals to underrepresented demographic groups, a Spanish-language curriculum version, and adaptive learning technology. Educators will have access to a Learning Management System, online classroom tools that are easy to implement both virtually and in-class, and an Administrative Dashboard for real-time school and school-district level reporting on student learning progress. The aims for this Phase II project are to show that the solution delivers the following learner benefits: (1) effective mastery of the fundamentals of genomics/genetics and personalized medicine, (2) effective understanding of the ethical and healthcare implications of genetics/genomics, (3) motivational impact on students, by promoting interest in genomics/STEM education and careers, (4) strong learning and motivational impact on underrepresented demographic groups. WestEd, will conduct To verify the attainment of these aims, the external research and evaluation partner, a Randomized Controlled Trial (with 750 9th grade students from classrooms with high populations of underserved students) on the fully developed educational solution. Aims 1-3 are supported if students in the treatment group show a pre- versus post-assessment performance improvement (measured in terms of information retention (Aim 1), attitudes towards the practical use of science (Aim 2), and interest in pursuing additional genomics/STEM education and a genomics/STEM career (Aim 3)) that is statistically larger than the improvements observed in the control group. Aim 4 is supported if performance in the treatment group is uncorrelated with demographic factors (i.e. males vs. females and minority vs. non-minority students). Overall, the engaging and inspirational learning solution proposed in this project will help better prepare tomorrow’s healthcare consumers and scientists and promote greater diversity in STEM education and practice.",
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                    "approved": true
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                "abstract": "The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.",
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