Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=title
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=title", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=title", "next": null, "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=title" }, "data": [ { "type": "Grant", "id": "11355", "attributes": { "award_id": "1S10OD034383-01", "title": "Zeiss LSM 980 Airyscan 2 laser scanning confocal microscope", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 27409, "first_name": "MONIKA", "last_name": "Aggarwal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-05-01", "end_date": "2024-04-30", "award_amount": 593045, "principal_investigator": { "id": 27410, "first_name": "Neal Mathew", "last_name": "Alto", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1215, "ror": "", "name": "UT SOUTHWESTERN MEDICAL CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "We are requesting funds to purchase a Zeiss LSM 980 Airyscan 2 confocal microscope for the Microbiology Live Cell Imaging Facility at UTSW Medical Center in Dallas, TX. The system will be dedicated to live cell imaging of Biosafety Level 2 (BSL2) pathogens, experiments that cannot be done on other shared university microscopes due to institutional biosafety regulations. Currently, the only microscope available for live imaging of BSL2 pathogens is over 14 years old and has no capability for super-resolution imaging, an advance in imaging technology with substantial benefits for visualizing tiny microorganisms. The Zeiss LSM 980 instrument will represent a significant addition to the research infrastructure of the university by providing up-to-date imaging technology for a sizable group of investigators in multiple campus departments who are working to understand human infectious diseases and the immune response. To date, the lack of state-of-the-art imaging technology for BSL2 research at UTSW has discouraged researchers from venturing into lines of investigation that involve visualizing living pathogenic microorganisms and how they function in infected cells. The long-term objective of this application is to provide a central, managed, safe imaging facility with modern equipment to support these important research directions. To meet this objective, we have already implemented a fully compliant BSL2 live imaging facility managed by the Microbiology department. The requested instrument will meet our need for a modern live cell imaging system that is suitable for a wide range of applications. The system includes 4 laser lines, Airyscan 2 to enable super- and confocal-resolution imaging with high sensitivity and minimal phototoxicity, and Multiplex plus 8x parallelization for high temporal resolution, a full incubation enclosure for maintaining cells under optimum culture conditions, a motorized scanning stage for multi-position acquisition, definite focus and a piezo z-stage for fast acquisition of z-stacks. Access to a BSL2-specific live cell imaging instrument will allow microbiology, infectious disease and immunology investigators at UTSW to take advantage of live imaging technology to better understand pathogens that impact human health worldwide (e.g. models of Mycoplasma tuberculosis, attenuated HIV, models of SARS-Cov2, herpesviruses, poxviruses, EHEC, Salmonella, Shigella, Listeria, Campylobacter, Leishmania, Trypanosoma). The ongoing coronavirus pandemic has clearly demonstrated the importance of understanding how these and other microbial agents evolve, survive, spread and bypass the human immune system.", "keywords": [ "14 year old", "2019-nCoV", "Attenuated", "Bypass", "Campylobacter", "Cells", "Communicable Diseases", "Dedications", "Equipment", "Escherichia coli EHEC", "Funding", "HIV", "Health", "Herpesviridae", "Human", "Image", "Imaging Device", "Imaging technology", "Immune response", "Immune system", "Immunology", "Incubated", "Institution", "Investigation", "Lasers", "Leishmania", "Listeria", "Medical center", "Microbiology", "Microscope", "Modeling", "Modernization", "Motor", "Mycoplasma", "Pathogenicity", "Phototoxicity", "Positioning Attribute", "Poxviridae", "Regulation", "Research", "Research Infrastructure", "Research Personnel", "Resolution", "Salmonella", "Scanning", "Shigella", "System", "Trypanosoma", "Tuberculosis", "Universities", "Visualization", "experimental study", "imaging facilities", "imaging system", "instrument", "live cell imaging", "microbial", "microorganism", "pandemic coronavirus", "parallelization", "pathogen", "superresolution imaging", "temporal measurement" ], "approved": true } }, { "type": "Grant", "id": "15182", "attributes": { "award_id": "1R01GM155729-01", "title": "Zwitterionic polyethylene glycol for therapeutic delivery", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 31602, "first_name": "Sailaja", "last_name": "Koduri", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-05", "end_date": "2026-06-30", "award_amount": 318457, "principal_investigator": { "id": 27922, "first_name": "Hao", "last_name": "Cheng", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 377, "ror": "https://ror.org/04bdffz58", "name": "Drexel University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Biologic drugs and nanomedicines with conjugated polyethylene glycol (PEG) show extended circulation in the blood, increasing therapeutic efficacy. The U.S. FDA has approved more than 30 PEGylated biologics, including proteins, nucleotides, and peptides, and a few PEGylated nanomedicines, for example COVID-19 mRNA vaccines. Attached PEG chains increase the hydrodynamic radiuses of these therapeutics to reduce their renal clearance during blood circulation. More importantly, PEG conceals therapeutics from immune cells by repelling plasma proteins, rendering therapeutics stealth behavior. The adsorption of a few types of plasma proteins onto therapeutics can lead to the removal of therapeutics by immune cells. PEG chains are hydrophilic and flexible. They can repel plasma proteins through a thermodynamic-driven entropic repulsion. Despite the unique advantage, the application of PEGylated therapeutics is limited by the presence of anti-PEG antibodies (aPEG Abs). These antibodies not only accelerate the clearance of PEGylated therapeutics and attenuate their efficacies but may also cause severe side effects. Varied percentages of populations were found to have pre- existing aPEG Abs in different studies, with the percentage as high as 40%. The high prevalence is likely due to the broad use of PEG in cosmetic and healthcare products. To further improve the pharmacokinetics of therapeutics and circumvent the problem of aPEG Abs, researchers have strived to find PEG alternatives. Among these alternative polymers, zwitterionic polymers have attracted the most attention. In contrast to PEG, zwitterionic polymers repel protein adsorption by forming a hydration layer around the polymers. We hypothesize that zwitterionic PEG (ZPEG) that combines the advantageous characteristics of both PEG and conventional zwitterionic polymers will be superior to them in extending the circulation of therapeutics and minimize the generation of anti-ZPEG antibodies. To develop a ZPEG to replace PEG for therapeutic delivery, we propose the following research plans: 1) synthesize and characterize ZPEG with different chemical structures and reveal the mechanism of enhanced blood circulation of ZPEG-modified proteins; 2) investigate the immunogenicity of ZPEG; 3) investigate the pharmacokinetics and immune responses of nanoparticles covered with ZPEG. Because of the broad application of PEG, an excellent PEG replacement will generate tremendous societal impact. This project will pave the way to replace PEG with ZPEG in therapeutic delivery for minimized side effects and consistent efficacy.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8342", "attributes": { "award_id": "5R01MH126468-02", "title": "“Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 6363, "first_name": "Julia L", "last_name": "Zehr", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-05-15", "end_date": "2025-03-31", "award_amount": 765608, "principal_investigator": { "id": 22463, "first_name": "Natalie Hiromi", "last_name": "Brito", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 167, "ror": "https://ror.org/0190ak572", "name": "New York University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20865, "first_name": "Moriah E", "last_name": "Thomason", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is exerting wide-spread impact on the lives of expectant mothers around the world. Particularly salient pandemic- related stressors that are being experienced by pregnant women are social isolation and uncertainty stress. There is ample physiological and behavioral literature showing that social isolation and uncertainty stress affect typical human and animal psychobiological functioning, but there is an absence of knowledge about how these conditions might impact the physical and psychological health of a pregnant woman, and what the consequences of those changes might be for her developing child. The central objective of this proposal is to build foundational knowledge about the effects of prenatal social isolation and uncertainty stress on maternal psychobiology and infant neurobehavior. We will explore several candidate physiological systems in the mother to elucidate mechanisms that underlie associations between maternal stressors and child outcomes. To achieve these goals, we will recruit 200 women from a large New York City cohort established at the height of the pandemic into a prospective, longitudinal study that will include pre- and postnatal biospecimen collection and child neurobehavioral assessments at 6-, 12- and 24 months. Multi-modal neuroimaging strategies, including infant EEG and quantitative MRI, and innovative remote biophysical data collection strategies will be employed. The primary aims of this project are to (i) examine the impact of prenatal social isolation and uncertainty stress on maternal biology and postnatal mental health; (ii) evaluate the influence of maternal prenatal social isolation and uncertainty stress on infant neurobehavioral development; and (iii) examine the role of prenatal social isolation and uncertainty stress on mother-infant bi-directional interactions. We will thus be able to meaningfully evaluate whether, and how, prenatal social isolation and uncertainty stress modify maternal biology and affect, and the neurobehavioral consequences of those impacts on infants. Such work would constitute a substantial advance in our understanding of the longitudinal effects of prenatal psychosocial stress exposures, the underlying mechanistic pathways, and the origins of child neurobehavioral disorders.", "keywords": [ "Address", "Affect", "Age", "Allopregnanolone", "Animals", "Architecture", "Area", "Attention", "Award", "Behavior", "Behavior assessment", "Behavioral", "Bioenergetics", "Biological", "Biology", "Biophysics", "Brain", "COVID-19", "COVID-19 pandemic", "Child", "Child Development", "Collection", "Communicable Diseases", "Data Collection", "Development", "Diffusion", "Disasters", "Economics", "Electrocardiogram", "Electroencephalogram", "Endocrine", "Enrollment", "Environment", "Etiology", "Event", "Fatty Acids", "Fiber", "Foundations", "Glucose", "Goals", "Health", "Height", "Home environment", "Hormonal", "Hour", "Human", "Human Development", "Hydrocortisone", "Infant", "Inflammation", "Inflammatory", "Investigation", "Knowledge", "Learning", "Leptin", "Life", "Literature", "Longitudinal Studies", "Magnetic Resonance Imaging", "Measures", "Medical", "Mental Health", "Modality", "Morbidity - disease rate", "Mothers", "Movement", "Myelin", "Neurocognitive", "New York City", "Outcome", "Parents", "Pathway interactions", "Perinatal", "Persons", "Phase", "Physiological", "Play", "Postpartum Depression", "Postpartum Period", "Pregnancy", "Pregnant Women", "Prevalence", "Psychopathology", "Psychosocial Stress", "Questionnaires", "Relaxation", "Research", "Risk", "Role", "Sinus Arrhythmia", "Social Environment", "Social isolation", "Societies", "Stress", "Sum", "Supervision", "Surveys", "System", "Testing", "Time", "Uncertainty", "United States National Institutes of Health", "Variant", "Woman", "Work", "arm", "awake", "base", "care providers", "cohort", "course development", "experience", "family support", "follow-up", "imaging approach", "innovation", "machine learning algorithm", "multimodality", "neurobehavior", "neurobehavioral", "neurobehavioral disorder", "neurodevelopment", "neuroimaging", "new technology", "offspring", "pandemic disease", "physical conditioning", "postnatal", "preclinical study", "pregnant", "prenatal", "prospective", "psychobiologic", "psychobiology", "psychologic", "public health relevance", "recruit", "remote sensing", "respiratory", "response", "restraint", "sensor technology", "serial imaging", "sound", "stressor", "tool" ], "approved": true } }, { "type": "Grant", "id": "8343", "attributes": { "award_id": "1R01MH126468-01", "title": "“Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 6363, "first_name": "Julia L", "last_name": "Zehr", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-05-15", "end_date": "2025-03-31", "award_amount": 871099, "principal_investigator": { "id": 22463, "first_name": "Natalie Hiromi", "last_name": "Brito", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 167, "ror": "https://ror.org/0190ak572", "name": "New York University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20865, "first_name": "Moriah E", "last_name": "Thomason", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is exerting wide-spread impact on the lives of expectant mothers around the world. Particularly salient pandemic- related stressors that are being experienced by pregnant women are social isolation and uncertainty stress. There is ample physiological and behavioral literature showing that social isolation and uncertainty stress affect typical human and animal psychobiological functioning, but there is an absence of knowledge about how these conditions might impact the physical and psychological health of a pregnant woman, and what the consequences of those changes might be for her developing child. The central objective of this proposal is to build foundational knowledge about the effects of prenatal social isolation and uncertainty stress on maternal psychobiology and infant neurobehavior. We will explore several candidate physiological systems in the mother to elucidate mechanisms that underlie associations between maternal stressors and child outcomes. To achieve these goals, we will recruit 200 women from a large New York City cohort established at the height of the pandemic into a prospective, longitudinal study that will include pre- and postnatal biospecimen collection and child neurobehavioral assessments at 6-, 12- and 24 months. Multi-modal neuroimaging strategies, including infant EEG and quantitative MRI, and innovative remote biophysical data collection strategies will be employed. The primary aims of this project are to (i) examine the impact of prenatal social isolation and uncertainty stress on maternal biology and postnatal mental health; (ii) evaluate the influence of maternal prenatal social isolation and uncertainty stress on infant neurobehavioral development; and (iii) examine the role of prenatal social isolation and uncertainty stress on mother-infant bi-directional interactions. We will thus be able to meaningfully evaluate whether, and how, prenatal social isolation and uncertainty stress modify maternal biology and affect, and the neurobehavioral consequences of those impacts on infants. Such work would constitute a substantial advance in our understanding of the longitudinal effects of prenatal psychosocial stress exposures, the underlying mechanistic pathways, and the origins of child neurobehavioral disorders.", "keywords": [ "Address", "Affect", "Age", "Allopregnanolone", "Animals", "Architecture", "Area", "Attention", "Award", "Behavior", "Behavior assessment", "Behavioral", "Bioenergetics", "Biological", "Biology", "Biophysics", "Brain", "COVID-19", "COVID-19 pandemic", "Child", "Child Development", "Collection", "Communicable Diseases", "Data Collection", "Development", "Diffusion", "Disasters", "Economics", "Electrocardiogram", "Electroencephalogram", "Endocrine", "Enrollment", "Environment", "Etiology", "Event", "Fatty Acids", "Fiber", "Foundations", "Glucose", "Goals", "Health", "Height", "Home environment", "Hormonal", "Hour", "Human", "Human Development", "Hydrocortisone", "Infant", "Inflammation", "Inflammatory", "Investigation", "Knowledge", "Learning", "Leptin", "Life", "Literature", "Longitudinal Studies", "Magnetic Resonance Imaging", "Measures", "Medical", "Mental Health", "Modality", "Morbidity - disease rate", "Mothers", "Movement", "Myelin", "Neurocognitive", "New York City", "Outcome", "Parents", "Pathway interactions", "Perinatal", "Phase", "Physiological", "Play", "Postpartum Depression", "Postpartum Period", "Pregnancy", "Pregnant Women", "Prevalence", "Psychopathology", "Psychosocial Stress", "Questionnaires", "Relaxation", "Research", "Risk", "Role", "Sinus Arrhythmia", "Social Environment", "Social isolation", "Societies", "Stress", "Sum", "Supervision", "Surveys", "System", "Testing", "Time", "Uncertainty", "United States National Institutes of Health", "Variant", "Woman", "Work", "arm", "awake", "base", "care providers", "cohort", "course development", "experience", "family support", "follow-up", "imaging approach", "innovation", "machine learning algorithm", "multimodality", "neurobehavior", "neurobehavioral", "neurobehavioral disorder", "neurodevelopment", "neuroimaging", "new technology", "offspring", "pandemic disease", "physical conditioning", "postnatal", "preclinical study", "pregnant", "prenatal", "prospective", "psychobiologic", "psychobiology", "psychologic", "public health relevance", "recruit", "remote sensing", "respiratory", "response", "restraint", "sensor technology", "serial imaging", "sound", "stressor", "tool" ], "approved": true } }, { "type": "Grant", "id": "10088", "attributes": { "award_id": "2218973", "title": "“Puerto Rican Higher Education Researchers Association, Thriving not just Surviving (HEARTS) conference", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Education and Human Resources (EHR)", "HSI-Hispanic Serving Instituti" ], "program_reference_codes": [], "program_officials": [ { "id": 2964, "first_name": "Sonja", "last_name": "Montas-Hunter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-15", "end_date": "2024-07-31", "award_amount": 34314, "principal_investigator": { "id": 25980, "first_name": "Kelly", "last_name": "Mack", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1883, "ror": "https://ror.org/015t7hs32", "name": "Association of American Colleges and Universities", "address": "", "city": "", "state": "DC", "zip": "", "country": "United States", "approved": true }, "abstract": "With support from the Improving Undergraduate STEM Education: Hispanic-Serving Institutions (HSI Program), this conference aims to support faculty in Puerto Rico so that they can impact the retention and graduation rates of Hispanic students through implementing best practices and improving faculty wellness, resulting in improved student/faculty engagement and faculty grant-writing skills. Puerto Rican faculty are in urgent need of physical, emotional, pedagogical, and financial support so that they can refresh, rejuvenate, and adapt to transition from surviving to thriving in this pandemic-fueled “new normal.” The Puerto Rican Higher Education Researchers Association, Thriving not just Surviving (HEARTS) Conference will provide this support for faculty to heal, learn, share and grow to better support Hispanic STEM students and the HSIs of Puerto Rico. The conference will bring together faculty in higher education research programs from across the island. The conference will address topics of wellness, grant-writing support, best practices for virtual and/or hybrid learning (especially in STEM) and culturally competent pedagogy. These four topics, combined into one event, will offer holistic support for the faculty that are on the frontlines of the implementation of education research programming that seeks to improve outcomes for Hispanic students in STEM and broadly in higher education in Puerto Rico. Faculty will be better equipped to meet the challenges of this “new normal” if they are supported by each other, focused on their own wellness, trained for writing competitive grants, and trained in best practices for hybrid and/or virtual STEM instruction in a culturally supportive environment to promote the success of Hispanic STEM students.\n\nThe design and analysis of this mixed-methods evaluative research study are based on Kezar’s (2013) framework of organizational learning through “sensemaking.” The project will help faculty “make sense” of their value and how they require personal wellness and stronger communities to be effective. Participants in the conference will learn about successful capacity-building efforts of other STEM faculty and administrators which resulted in student success. The conference will address the topics of (1) faculty wellness, (2) creating communities through sustained dialogues, (3) grant-writing, and (4) culturally responsive pedagogies. The main goals are to (1) equip HSI faculty from PR to meet the challenges of today’s “new normal” by focusing on their own wellness; (2) create a sustained dialogue on the importance of collaboration among HSIs in Puerto Rico and in the US; (3) empower faculty to use best practices for Hispanic students to promote the success and (4) receive training for competitive grant-writing (to secure funds to support their work). The conference activities will generate evidence of faculty improved faculty wellbeing, sense of belonging, self-efficacy in grant-writing, and implementation of best practices in the classroom to support STEM students. This evidence will be used to seek additional funding to support yearly iterations of the conference with the long-term goal of forming a self-sustaining education research association on the island that will foster long-term excellence in higher education research for HSIs in Puerto Rico as well as collaborations with the US mainland to promote education research that builds capacity for student success. The HSI Program aims to enhance undergraduate STEM education and build capacity at HSIs. Projects supported by the HSI Program will also generate new knowledge on how to achieve these aims.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10668", "attributes": { "award_id": "1C06OD034041-01", "title": "“Renovation of Building 29 laboratories at the New Iberia Research Center\"", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-19", "end_date": "2026-08-31", "award_amount": 2000000, "principal_investigator": { "id": 24751, "first_name": "Francois J", "last_name": "Villinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette has undergone tremendous growth over the last 6 years adding some 3000 nonhuman primates for a current total of 9400 animals on site, and its research expenditure rose from ~19 to over 70 million between FY2016 and 2021. This expansion has been markedly accelerated during the COVID pandemic in 2 ways: 1) NIRC has supported the testing of no less than 12 COVID vaccines including the Pfizer-BioNTech as well as monitored the distribution and pharmacokinetics of convalescent antibodies via dynamic PET/CT imaging. 2) Owing to fact that many labs were closed across US institutions during 2020, NIRC scientists ensured that ongoing nonhuman primate experiments could be continued to avoid wasting precious resources. The expansion of NIRC’s in house HIV/AIDS research program is currently limited by the lack of additional research laboratory space to house new hires and their teams, with several candidates interested in joining NIRC and the University of Louisiana at Lafayette, which in December 2021 obtained the coveted R1 status by the Carnegie Commission on Institutions of Higher Education. In preparation of such laboratory expansion, NIRC has completed the demolition of the third floor of Building 29 (~9100 sq ft) along with complete and certified asbestos removal. This space will be ideal to house up to 6 research teams in a combination of open shared as well as separate laboratory spaces, complete with offices, cubicles and a conference room. NIRC supports many onsite and collaborative programs on using nonhuman primates on various metabolic and infectious diseases, most notably HIV lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to single cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the fight against COVID-19. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the breeding and the transfer of new programs such as the NIAID funded SVEU breeding program. In addition to over 6500 Indian origin rhesus macaques, NIRC is breeding and using Mauritian cynomolgus macaques and African green monkeys as well as a few pigtailed macaques. This NHP program is largely supported by a state-of-the-art onsite clinical laboratory, expert veterinary care and equipment. NIRC has also established an expandable rodent vivarium in the support of research and is planning to build a BSL-3 facility complete with laboratories, rodent and monkey housing. The addition of research laboratories at NIRC will markedly enhance the ability of the Center to assemble a critical mass of scientists focused on HIV research, expanding the breath of the research program fully supported by NHP models, and compete for external funding.", "keywords": [ "AIDS/HIV problem", "African Green Monkey", "Animals", "Antibodies", "Asbestos", "Breeding", "COVID-19", "COVID-19 pandemic", "Caring", "Clinical", "Colorectal", "Communicable Diseases", "Drug Kinetics", "Ensure", "Equipment", "Excision", "Expenditure", "Floor", "Funding", "Growth", "HIV", "Housing", "Institution", "Laboratories", "Laboratory Research", "Louisiana", "Macaca", "Macaca fascicularis", "Macaca mulatta", "Macaca nemestrina", "Metabolic Diseases", "Modeling", "Monitor", "Monkeys", "Mucous Membrane", "National Institute of Allergy and Infectious Disease", "PET/CT scan", "Pathogenesis", "Preparation", "Research", "Research Support", "Resources", "Rodent", "Scientist", "Site", "Testing", "Therapeutic", "Universities", "Vaccines", "Vagina", "Viral", "X-Ray Computed Tomography", "biosafety level 3 facility", "building renovation", "coronavirus disease", "experimental study", "fight against", "higher education", "imaging capabilities", "interest", "microbicide", "nonhuman primate", "pandemic disease", "prevent", "programs", "single cell analysis", "symposium", "wasting" ], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1405, "count": 14046 } } }