Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=title
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=title", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=title", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=title", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=title" }, "data": [ { "type": "Grant", "id": "1170", "attributes": { "award_id": "2128836", "title": "Upskilling Workers and Re-designing Workplaces for the Future of Automation in the Hospitality Industry", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)" ], "program_reference_codes": [], "program_officials": [ { "id": 2973, "first_name": "Balakrishnan", "last_name": "Prabhakaran", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-10-15", "end_date": "2025-09-30", "award_amount": 446021, "principal_investigator": { "id": 2974, "first_name": "Christine A", "last_name": "Riordan", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 281, "ror": "", "name": "University of Illinois at Urbana-Champaign", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 281, "ror": "", "name": "University of Illinois at Urbana-Champaign", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "This multi-institutional collaborative research project seeks to envision, design and engage in worker-oriented research and training related to the proliferation of automation in the hospitality industry, which has been accelerated by the COVID-19 pandemic. Large numbers of hospitality workers, who are majority female and from underrepresented groups, are being displaced by these technological changes. Workers’ positions are currently being augmented with algorithmic management and robotic assistance, replacing some jobs and transforming others that cannot be completely automated — for example, high-touch, face-to-face service interactions which are critical to the success of the hospitality industry. The research team will investigate ways that technological innovations of the future can be developed and implemented with input from the workers who are best suited to understand their benefits and pitfalls. It is expected that this project will positively impact the hospitality workforce by preserving jobs, giving people more job satisfaction, reducing the way technology drives inequality, and developing policies and training programs that will generalize to other high-touch service industries.This project brings together several disciplines, including hospitality, human-computer interaction, service design, learning science, labor economics, and industrial relations. The research team has partnered with UNITE HERE, the largest hospitality union in the United States, which will provide a unique opportunity to research, prototype, and evaluate the research outcomes in training facilities and hotels, casinos, and food service establishments. The investigator team is structured to achieve multiple convergent goals. This process will have four iterative, overlapping phases: (1) to qualitatively and quantitatively understand the current state of union hospitality workers, hospitality work, and automation technology; (2) to co-design technology deployment models; (3) to identify workforce needs and training materials to prepare for the future; and (4) to evaluate outcomes to understand how they may impact the future of work. The project will address the lack of worker voice on the impact of future automation technology in the hospitality industry, and to make suggestions for enhancing future workers and future work. This project is funded by the NSF Future of Work at the Human-Technology Frontier cross-directorate program to promote deeper basic understanding of the interdependent human-technology partnership in work contexts by advancing the design of intelligent work technologies that operate in harmony with human workers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5228", "attributes": { "award_id": "1R01AI169239-01", "title": "Uptake, Safety and Effectiveness of COVID‐19 Vaccines during Pregnancy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 18489, "first_name": "BROOKE ALLISON", "last_name": "Bozick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-04-08", "end_date": "2025-03-31", "award_amount": 511677, "principal_investigator": { "id": 18490, "first_name": "Annette Karena", "last_name": "Regan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 883, "ror": "https://ror.org/029m7xn54", "name": "University of San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Pregnant persons are at increased risk for severe COVD-19 illness compared to non-pregnant women of reproductive age, experiencing higher rates of admission to intensive care, mechanical ventilation and death. In addition to the direct impacts on the health of pregnant persons, there is growing evidence to suggest COVID-19 adversely impacts fetal and neonatal health. As of May 2021, three vaccines have been issued Emergency Use Approval in the US. However, because pregnant persons were excluded from initial Phase 3 clinical trials, data to confirm the safety and effectiveness of COVID-19 vaccination during pregnancy are lacking. Driven by this limited data, obstetric and public health governing bodies do not currently directly recommend vaccination for pregnant persons. The American College of Obstetricians and Gynecologists and the US Centers for Disease Control and Prevention (CDC) advise that COVID-19 vaccines should not be withheld from pregnant persons. As a result, the decision to vaccinate is made at the individual level, and pregnant persons express anxiety around making this decision. Additional data to inform the safety and effectiveness of COVID-19 vaccines administered during pregnancy would strengthen current clinical guidelines. Despite weak guidance, individuals are choosing to be vaccinated during pregnancy. As of 3 May 2021, 106,241 pregnant persons were reported as having received a COVID-19 vaccine through V-SAFE, the CDC’s active vaccine safety surveillance system. When surveyed, more than 50% of pregnant persons report an intention to receive a COVID-19 vaccine. Phase 2/3 clinical trial data are currently being gathered to evaluate safety and efficacy. While these clinical trial data are being collected, we have the opportunity to learn from large observational studies of pregnant persons who have chosen to be vaccinated. Leveraging existing national medical claims and electronic medical records for more than 870,000 pregnancies, we plan to conduct large-scale post-implementation cohort studies to evaluate the uptake, safety and effectiveness of COVID-19 vaccines administered during pregnancy. Completion of the proposed research will provide important epidemiological evidence on the safety and effectiveness of COVID-19 vaccination during pregnancy. This evidence will aid informed decision and policy-making around COVID-19 vaccination for pregnant persons.", "keywords": [ "2019-nCoV", "Admission activity", "Advisory Committees", "Age", "American College of Obstetricians and Gynecologists", "Anxiety", "COVID-19", "COVID-19 diagnosis", "COVID-19 vaccination", "COVID-19 vaccine", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Clinical", "Clinical Trials", "Cohort Studies", "Computerized Medical Record", "Data", "Databases", "Decision Making", "Discipline of obstetrics", "Disease", "Effectiveness", "Electronic Health Record", "Eligibility Determination", "Emergency Situation", "Ensure", "Epidemiology", "Event", "Exposure to", "FDA Emergency Use Authorization", "Fetal health", "Goals", "Guidelines", "Health", "Health Personnel", "Immunization", "Individual", "Infant", "Infant Health", "Infection", "Intensive Care", "Intention", "Lead", "Learning", "Link", "Maternal Health", "Mechanical ventilation", "Medical", "Mothers", "Nature", "Observational Study", "Outcome", "Participant", "Passive Immunity", "Perinatal", "Perinatal mortality demographics", "Persons", "Phase", "Phase II/III Clinical Trial", "Phase III Clinical Trials", "Planned Pregnancy", "Policy Making", "Population", "Population Group", "Population Policies", "Pregnancy", "Pregnancy loss", "Premature Birth", "Probability", "Public Health", "Recommendation", "Reporting", "Research", "Risk", "Risk Factors", "SARS-CoV-2 infection", "Safety", "Special Event", "Surveys", "System", "Time", "Update", "Vaccinated", "Vaccination", "Vaccines", "adverse outcome", "adverse pregnancy outcome", "care providers", "experience", "fetal", "high risk", "implementation evaluation", "influenza virus vaccine", "interest", "maternal outcome", "neonatal health", "neonatal outcome", "neonate", "new technology", "perinatal health", "policy implication", "policy recommendation", "post implementation", "pregnant", "prevent", "programs", "reproductive", "severe COVID-19", "sociodemographics", "systematic review", "uptake", "vaccination outcome", "vaccination strategy", "vaccine acceptance", "vaccine safety", "variants of concern" ], "approved": true } }, { "type": "Grant", "id": "11645", "attributes": { "award_id": "5R01AI169239-02", "title": "Uptake, Safety and Effectiveness of COVID‐19 Vaccines during Pregnancy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6243, "first_name": "BROOKE ALLISON", "last_name": "Bozick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-04-08", "end_date": "2025-03-31", "award_amount": 383326, "principal_investigator": { "id": 7298, "first_name": "Annette Karena", "last_name": "Regan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 883, "ror": "https://ror.org/029m7xn54", "name": "University of San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 883, "ror": "https://ror.org/029m7xn54", "name": "University of San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Pregnant persons are at increased risk for severe COVD-19 illness compared to non-pregnant women of reproductive age, experiencing higher rates of admission to intensive care, mechanical ventilation and death. In addition to the direct impacts on the health of pregnant persons, there is growing evidence to suggest COVID-19 adversely impacts fetal and neonatal health. As of May 2021, three vaccines have been issued Emergency Use Approval in the US. However, because pregnant persons were excluded from initial Phase 3 clinical trials, data to confirm the safety and effectiveness of COVID-19 vaccination during pregnancy are lacking. Driven by this limited data, obstetric and public health governing bodies do not currently directly recommend vaccination for pregnant persons. The American College of Obstetricians and Gynecologists and the US Centers for Disease Control and Prevention (CDC) advise that COVID-19 vaccines should not be withheld from pregnant persons. As a result, the decision to vaccinate is made at the individual level, and pregnant persons express anxiety around making this decision. Additional data to inform the safety and effectiveness of COVID-19 vaccines administered during pregnancy would strengthen current clinical guidelines. Despite weak guidance, individuals are choosing to be vaccinated during pregnancy. As of 3 May 2021, 106,241 pregnant persons were reported as having received a COVID-19 vaccine through V-SAFE, the CDC’s active vaccine safety surveillance system. When surveyed, more than 50% of pregnant persons report an intention to receive a COVID-19 vaccine. Phase 2/3 clinical trial data are currently being gathered to evaluate safety and efficacy. While these clinical trial data are being collected, we have the opportunity to learn from large observational studies of pregnant persons who have chosen to be vaccinated. Leveraging existing national medical claims and electronic medical records for more than 870,000 pregnancies, we plan to conduct large-scale post-implementation cohort studies to evaluate the uptake, safety and effectiveness of COVID-19 vaccines administered during pregnancy. Completion of the proposed research will provide important epidemiological evidence on the safety and effectiveness of COVID-19 vaccination during pregnancy. This evidence will aid informed decision and policy-making around COVID-19 vaccination for pregnant persons.", "keywords": [ "2019-nCoV", "Admission activity", "Advisory Committees", "Age", "American College of Obstetricians and Gynecologists", "Anxiety", "COVID-19", "COVID-19 diagnosis", "COVID-19 impact", "COVID-19 vaccination", "COVID-19 vaccine", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Clinical", "Clinical Trials", "Cohort Studies", "Computerized Medical Record", "Data", "Databases", "Decision Making", "Discipline of obstetrics", "Disease", "Effectiveness", "Electronic Health Record", "Eligibility Determination", "Emergency Situation", "Ensure", "Epidemiology", "Event", "Exclusion", "FDA Emergency Use Authorization", "Fetal health", "Goals", "Guidelines", "Health", "Health Personnel", "Immunization", "Individual", "Infant", "Infant Health", "Infection", "Intensive Care", "Intention", "Learning", "Link", "Maternal Health", "Mechanical ventilation", "Medical", "Mothers", "Nature", "Observational Study", "Outcome", "Participant", "Passive Immunity", "Perinatal", "Perinatal mortality demographics", "Persons", "Phase", "Phase II/III Clinical Trial", "Phase III Clinical Trials", "Planned Pregnancy", "Policies", "Policy Making", "Population", "Population Group", "Pregnancy", "Pregnancy loss", "Premature Birth", "Probability", "Public Health", "Recommendation", "Reporting", "Research", "Risk", "Risk Factors", "SARS-CoV-2 exposure", "SARS-CoV-2 infection", "Safety", "Special Event", "Surveys", "System", "Time", "Update", "Vaccinated", "Vaccination", "Vaccines", "Woman", "adverse outcome", "adverse pregnancy outcome", "care providers", "experience", "fetal", "high risk", "implementation evaluation", "influenza virus vaccine", "interest", "maternal outcome", "neonatal health", "neonatal outcome", "neonate", "new technology", "policy implication", "policy recommendation", "post SARS-CoV-2 infection", "post implementation", "pregnant", "prevent", "programs", "reproductive", "severe COVID-19", "sociodemographics", "systematic review", "unvaccinated", "uptake", "vaccination outcome", "vaccination strategy", "vaccine acceptance", "vaccine safety", "variants of concern" ], "approved": true } }, { "type": "Grant", "id": "6583", "attributes": { "award_id": "3U01AA020776-10S2", "title": "URBAN ARCH (3/5) Uganda Cohort TB preventive therapy for HIV-infected alcohol users in Uganda: an evaluation of safety tolerability and adherence", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 22059, "first_name": "LI", "last_name": "Lin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-09-22", "end_date": "2022-08-31", "award_amount": 164963, "principal_investigator": { "id": 22060, "first_name": "JUDITH ALISSA", "last_name": "HAHN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "This application proposes the Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPT-TB) study, a continuation of the Uganda Alcohol Research Collaboration on HIV (ARCH) cohort of HIV-infected alcohol users in Uganda. Tuberculosis (TB) is the leading cause of mortality in persons with HIV. Isoniazid (INH) preventive therapy (IPT) decreases all-cause mortality and active TB in persons with HIV by 30-50% above and beyond the benefits of antiretroviral therapy (ART) alone. Based on these findings, the World Health Organization (WHO) recommends IPT for all persons with HIV in resource constrained settings, but warns against IPT for persons with “regular and heavy alcohol use” due to concern for increased hepatotoxicity in heavy drinkers in settings where liver enzymes are not routinely monitored. Approximately one quarter of HIV- infected persons in sub-Saharan Africa (SSA) are heavy drinkers, but no studies have systematically assessed the safety of TB preventive therapy in alcohol users. Thus, the ADEPT-TB study aims to determine the safety and tolerability of TB preventive therapy for HIV-infected drinkers, and examine if the benefits in preventing TB outweigh the risks. Adherence to TB preventive therapy impacts the level of benefit and may also impact hepatotoxicity. Alcohol use is an established risk factor for decreased ART adherence and active TB treatment discontinuation, but it is not known whether HIV-infected drinkers on daily ART can be adherent to TB preventive therapy. Standard IPT is comprised of daily INH for 6-9 months; a shorter-course, such as 3 months of INH plus rifampicin, could improve adherence. The ADEPT-TB study will examine the safety and tolerability of, and adherence to, 6 months of daily INH (6H) and 3 months of daily INH plus rifampicin (3HR) in 380 HIV-infected drinkers in Uganda. We will randomize participants to one of the two regimens (n=190 per arm). Our first aim is to evaluate the safety and tolerability within each regimen and by level of alcohol use. Our second aim is to compare adherence by regimen; we hypothesize that adherence will be greater in the 3HR arm compared to the 6H arm. Self-reported measures of alcohol use will be augmented by phosphatidylethanol (PEth), an established biomarker of alcohol use. Objective measures of adherence will include electronic pill bottle monitoring and a novel measure of INH exposure, INH concentration in hair. We will actively monitor for hepatotoxicity using the U.S. standard of care for TB preventive therapy for heavy drinkers. We will use the safety, tolerability, and adherence results, together with the known efficacy and mortality benefit of TB preventive therapy in HIV-infected persons in SSA, and an established decision analytic model of TB preventive therapy to conduct our third aim: to determine whether the benefits of TB preventive therapy outweigh the toxicity risks for HIV-infected drinkers in resource limited settings. These data will provide critical insights to inform the guidelines for TB preventive therapy for alcohol-using, HIV-infected persons in TB endemic areas where HIV and alcohol use are common.", "keywords": [ "AIDS/HIV problem", "Accounting", "Adherence", "Africa South of the Sahara", "Alcohol consumption", "Alcoholic beverage heavy drinker", "Alcohols", "Area", "Biological Markers", "Boston", "Cessation of life", "Clinical", "Collaborations", "Control Groups", "Data", "Disease", "Enzymes", "Ethics", "Evaluation", "Exclusion", "Exposure to", "Family", "Guidelines", "HIV", "HIV Infections", "HIV therapy", "HIV/TB", "Hair", "Heavy Drinking", "Hepatotoxicity", "Laboratories", "Life Expectancy", "Liver", "Measures", "Modeling", "Monitor", "Morbidity - disease rate", "Participant", "Patient Self-Report", "Persons", "Pharmaceutical Preparations", "Population", "Prevention", "Preventive", "Preventive therapy", "Quality-Adjusted Life Years", "Randomized", "Records", "Regimen", "Research", "Resources", "Rifampin", "Rifamycins", "Risk", "Risk Factors", "Russia", "Safety", "Toxic effect", "Tuberculosis", "Uganda", "United States National Institutes of Health", "World Health Organization", "alcohol comorbidity", "alcohol measurement", "alcohol research", "antiretroviral therapy", "arm", "base", "cohort", "comparative efficacy", "drinking", "high risk", "improved", "insight", "isoniazid", "mortality", "novel", "phosphatidylethanol", "pill", "prevent", "standard of care", "stem", "therapy adherence", "treatment adherence", "tuberculosis treatment" ], "approved": true } }, { "type": "Grant", "id": "5743", "attributes": { "award_id": "3U01AA020784-10S2", "title": "URBAN ARCH (5/5) Boston Cohort - Alcohol and HIV-associated comorbidity and complications: Frailty, Functional impairment, Falls, and Fractures (the 4F study)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 19794, "first_name": "Joe", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-09-20", "end_date": "2022-08-31", "award_amount": 161316, "principal_investigator": { "id": 19795, "first_name": "Timothy C.", "last_name": "Heeren", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 19796, "first_name": "Theresa W", "last_name": "Kim", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 860, "ror": "", "name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Up to a third of middle-aged people living with HIV infection (PLWH) experience falls each year. Falls are the most common cause of non-fatal injury in the US and the cost from emergency department visits and hospitalizations are enormous. PLWH are more susceptible to falls and their serious consequences because 1) despite control of HIV viremia, inflammation persists and underlies HIV-associated comorbidities and complications that occur at a relatively young age (so-called premature aging), 2) specific comorbidities (e.g. neuropathy, osteoporosis) and complications (e.g. frailty and impaired physical function) make falls more likely and recovery from them more difficult, 3) alcohol use exacerbates inflammation, and may increase risk for comorbidities and complications, and 4) alcohol use, illicit drug use and polypharmacy can increase the likelihood of a fall. Despite this, fall prevention has not been extensively studied among PLWH. We need interventions to address falls in PLWH but none have been tailored for this population. Understanding risk factors and targets for intervention among PLWH are essential; cohort studies can provide the information needed for intervention development. This proposal is part the Consortia for HIV/AIDS and Alcohol-Related Research Trials (CHAART). It describes the continuation and expansion of a cohort that is one of three in the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH). The URBAN ARCH theme is to address consequences of alcohol use on HIV-associated comorbidities and complications to increase treatment availability and improve outcomes. In line with that theme we propose to continue to follow and expand (to 400) an existing cohort of PLWH and a high prevalence of exposure to alcohol, illicit drugs, and polypharmacy (the Boston ARCH Cohort) in the Frailty, Functional impairment, Falls, and Fractures (4F study) to: (in 2 Primary Aims) 1) Test the associations between alcohol (and illicit drugs and polypharmacy) and falls (fractures secondarily); and 2) Test the associations between alcohol (and illicit drugs and polypharmacy) and acute healthcare utilization (emergency department use and hospitalization for falls and fractures). We will also examine the role frailty plays in these associations between alcohol, drugs and medications and the aforementioned clinical and utilization outcomes. In Exploratory Aims we will test associations between alcohol use and inflammatory markers, and between markers and HIV-associated complication outcomes (4Fs); and develop and pilot test the feasibility of a falls prevention intervention tailored to address the identified risk factors (e.g. alcohol, illicit drugs, polypharmacy) in this population. By achieving these aims we will gain substantially greater understanding of these comorbidities and complications in PLWH exposed to alcohol and other psychoactive substances; this knowledge will serve to inform the development of ways to identify, prevent and manage falls, fractures, frailty and functional impairment.", "keywords": [ "AIDS/HIV problem", "Accident and Emergency department", "Acute", "Address", "Affect", "Age", "Aging", "Alcohol consumption", "Alcohols", "Body Weight decreased", "Boston", "Cessation of life", "Clinical", "Cohort Studies", "Collaborations", "Complication", "Development", "Disease", "Drug usage", "Elderly", "Emergency department visit", "Fall prevention", "Fracture", "HIV", "HIV Infections", "HIV risk", "Hepatitis C co-infection", "High Prevalence", "Hospitalization", "Illicit Drugs", "Impairment", "Inflammation", "Injury", "Intervention", "Intervention Studies", "Knowledge", "Lead", "Mediating", "Mediation", "Morbidity - disease rate", "Nature", "Neuropathy", "Opioid", "Osteopenia", "Osteoporosis", "Osteoporotic", "Outcome", "Pharmaceutical Preparations", "Phenotype", "Physical Function", "Play", "Polypharmacy", "Population", "Premature aging syndrome", "Recovery", "Research", "Research Priority", "Risk", "Risk Factors", "Role", "Russia", "Substance Use Disorder", "Testing", "Translating", "Uganda", "United States National Institutes of Health", "Viremia", "Walking", "alcohol and other drug", "alcohol consequences", "alcohol exposure", "alcohol research", "antiretroviral therapy", "base", "cohort", "comorbidity", "cost", "efficacious intervention", "exhaustion", "experience", "fall risk", "falls", "feasibility testing", "frailty", "functional disability", "grasp", "health care service utilization", "high risk", "illicit drug use", "improved outcome", "inflammatory marker", "microbial", "middle age", "mortality", "prevent", "preventive intervention", "substance use", "systematic review", "therapy development", "virology" ], "approved": true } }, { "type": "Grant", "id": "7035", "attributes": { "award_id": "3U01AA020784-10S1", "title": "URBAN ARCH (5/5) Boston Cohort - Alcohol and HIV-associated comorbidity and complications: Frailty, Functional impairment, Falls, and Fractures (the 4F study)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 9113, "first_name": "Joe", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-09-20", "end_date": "2022-08-31", "award_amount": 163640, "principal_investigator": { "id": 10582, "first_name": "Timothy C.", "last_name": "Heeren", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 860, "ror": "", "name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 10583, "first_name": "Theresa W", "last_name": "Kim", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 860, "ror": "", "name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "This proposal is an urgent competitive revision designed to supplement an existing NIH-funded study to assess the impact of the COVID-19 pandemic on alcohol and other drug use, and medication adherence that is critical for preventing HIV disease progression, among people living with HIV (PLWH). The COVID-19 pandemic has profoundly affected lives around the world. In addition to the effects of infection itself, to which PLWH may be more susceptible, COVID-19 has affected employment, access to healthcare, and very likely, the incidence and consequences of other health conditions, by limiting access to healthcare, and through the implementation of physical (social) distancing. PLWH may be at higher risk of consequences of social isolation, and those with addiction, unemployment and homelessness are at an even higher risk with restrictions that affect food availability, hygiene (e.g. handwashing), shelter, and other traditional supports now absent from the already fragile societal safety net. The over-arching goal of this proposal is to assess the impact of the COVID-19 pandemic and the effects of physical (social) distancing and other mitigation strategies (collectively termed “pandemic exposure”) on substance use (heavy alcohol use and/or other drug use including nonmedical prescription medication use) and HIV medication adherence among PLWH. Among an ongoing, well-characterized cohort of people living with HIV/AIDS (the existing Boston ARCH Cohort parent study), this project will: Aim 1: Determine prospective associations between pandemic exposure and changes in alcohol (and other drug) use (primarily) and HIV antiretroviral (ARV) medication nonadherence (secondarily). Aim 2: Identify associations between pandemic exposure and secondary stressors, specifically, food insecurity, loneliness, and pain interference (with activities); and associations between those stressors and changes in alcohol (and other drug) use and HIV ARV medication nonadherence. Aim 3: Determine who is most affected by the pandemic by examining moderators of the associations between pandemic exposure and changes in substance use and HIV ARV nonadherence. To achieve these aims, a supplemental COVID-19 specific assessment will be administered to participants at two time points (6 months apart). Baseline data on substance use, depression, and frailty, collected during pre-pandemic assessments as part of the parent study will be compared against data collected via supplemental COVID-specific assessments. Achieving this proposal’s aims is an important step to identifying modifiable targets for interventions to prevent increased substance use and HIV disease progression after an extreme event such as COVID-19.", "keywords": [ "2019-nCoV", "AIDS/HIV problem", "Acquired Immunodeficiency Syndrome", "Acute", "Address", "Affect", "Alcohol consumption", "Alcohol or Other Drugs use", "Alcohols", "Anti-Retroviral Agents", "Area", "Award", "Boston", "COVID-19", "COVID-19 pandemic", "Cessation of life", "Collaborations", "Coronavirus", "County", "Data", "Data Analyses", "Disease", "Disease Progression", "Drug Use Disorder", "Drug usage", "Emergency Situation", "Employment", "Epidemic", "Event", "Exposure to", "Fire - disasters", "Food", "Fracture", "Funding", "Goals", "HIV", "HIV Infections", "HIV Seropositivity", "HIV antiretroviral", "Handwashing", "Health", "Health Services Accessibility", "Health system", "Healthcare Systems", "Heavy Drinking", "Homelessness", "Hygiene", "Illicit Drugs", "Incidence", "Infection", "Infrastructure", "Intervention", "Interview", "Lead", "Loneliness", "Massachusetts", "Mental Depression", "Mental Health", "Mission", "National Institute on Alcohol Abuse and Alcoholism", "Natural Disasters", "Outcome", "Pain interference", "Parents", "Participant", "Pharmaceutical Preparations", "Population", "Prevalence", "Preventive care", "Prospective Studies", "Prospective cohort", "Public Health", "Research", "Research Priority", "Risk", "Russia", "Severities", "Shelter facility", "Social Distance", "Social isolation", "Social support", "Stress", "Substance Use Disorder", "Surveys", "Symptoms", "Time", "Translational Research", "Uganda", "Uncertainty", "Unemployment", "United States National Institutes of Health", "addiction", "alcohol and other drug", "alcohol research", "alcohol use disorder", "co-infection", "cohort", "comorbidity", "coronavirus disease", "depressive symptoms", "design", "falls", "food insecurity", "frailty", "functional disability", "health care availability", "high risk", "infection rate", "medication compliance", "medication nonadherence", "member", "novel", "novel coronavirus", "opioid mortality", "pandemic disease", "parent grant", "prevent", "prospective", "safety net", "stressor" ], "approved": true } }, { "type": "Grant", "id": "7436", "attributes": { "award_id": "3U01AA020780-10S1", "title": "URBAN ARCH 4/5 Russia Cohort-Targeting HIV-comorbidities with Pharmacotherapy to Reduce Alcohol and Tobacco Use in HIV-infected Russians", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 9113, "first_name": "Joe", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-09-20", "end_date": "2022-08-31", "award_amount": 186966, "principal_investigator": { "id": 20671, "first_name": "MATTHEW S", "last_name": "FREIBERG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1220, "ror": "https://ror.org/010b9wj87", "name": "Boston Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20672, "first_name": "JEFFREY H.", "last_name": "SAMET", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 20673, "first_name": "Hilary A", "last_name": "Tindle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1220, "ror": "https://ror.org/010b9wj87", "name": "Boston Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Over 4,000,000 people worldwide are infected with COVID19 and cases are rising. Acute respiratory infections (e.g., Severe Acute Respiratory Virus), are associated with increased cardiovascular disease (CVD) risk, and early data indicate that COVID19 is associated with higher CVD risk. People living with HIV (PLWH) also have increased CVD risk compared to uninfected people and this risk is highest among those who are hazardous drinkers and smokers. Our research is designed to reduce CVD risk among these high risk PLWH and to elucidate key mechanism(s). St PETER HIV (U01AA020780) is a randomized controlled trial in St. Petersburg, Russia comparing the effects of nicotinic partial agonists on alcohol consumption, smoking, and inflammation and CVD risk among PWLH who are heavy drinkers and smokers. The Alcohol associated Comorbidity and Microbiome Evaluation (ACME ½ U01AA026222) study, nested within St PETER HIV, examines the gut microbiome as a novel pathway for increased CVD risk among these PLWH. HIV infection and hazardous drinking both cause microbial translocation, which increases systemic inflammation and leads to CVD. Whether COVID19 co-infection among PLWH who drink and smoke increases inflammation, alters the gut microbiome (i.e., reduces beneficial butyrate-producing bacteria which protect the gut from microbial translocation) and by extension alters the plasma metabolome (e.g., reduces plasma butyrate levels) is unknown. Sparse data describe the prevalence of COVID19 among PLWH who are heavy drinkers and smokers, and no data exist assessing the association between COVID19 and biomarker levels of inflammation and the plasma metabolome (e.g., butyrate) in this population. Our overarching hypothesis is that COVID19 is a CVD risk factor among heavy drinking and smoking PLWH. For this application, we hypothesize that COVID19 infection will be: (1) common among St PETER HIV participants; (2) associated with increased inflammation (e.g., higher IL-6); and (3) associated with an unfavorable metabolomic profile (i.e., lower plasma butyrate) as compared to those not infected with COVID19. To test our hypotheses, we will leverage existing data from and collect new data among St PETER HIV and ACME 1/2 participants including alcohol measures using the timeline follow-back; biomarkers of inflammation, data on comorbid conditions, longitudinal stored blood and fecal samples and imaging data. New data will include: COVID19 survey items and testing, alcohol and smoking data, and inflammatory/metabolomic biomarker testing. We will leverage these data to complete Aim 1: to describe and estimate prevalence of COVID19 infection in the St PETER HIV cohort; Aim 2: to determine the association between COVID19 infection and biomarkers of systemic inflammations; and Aim 3 (exploratory) to determine metabolic profiles among heavy drinking and smoking PLWH. Completing these aims will advance understanding of COVID19 effects on innate immune function and the plasma metabolome. Results will inform future interventions targeting the GI microbiome among PLWH.", "keywords": [ "Acute", "Acute respiratory infection", "Agonist", "Alcohol consumption", "Alcohol or Other Drugs use", "Alcoholic beverage heavy drinker", "Alcohols", "Atherosclerosis", "Back", "Bacteria", "Biological Assay", "Biological Markers", "Blood", "Blood specimen", "Butyrates", "C-reactive protein", "COVID-19", "Cardiovascular Diseases", "Data", "Development", "Echocardiography", "Epidemiology", "Equilibrium", "Evaluation", "Future", "HIV", "HIV Infections", "HIV-1", "Heavy Drinking", "Hepatic", "Image", "Infection", "Inflammation", "Inflammatory", "Innate Immune Response", "Interleukin-6", "Intervention", "Intervention Trial", "Intestinal permeability", "Laboratories", "Literature", "Measures", "Participant", "Pathway interactions", "Pharmacotherapy", "Plasma", "Population", "Prevalence", "RNA", "Randomized Controlled Trials", "Reporting", "Research", "Risk", "Risk Factors", "Role", "Russia", "Sampling", "Smoke", "Smoker", "Smoking", "Specimen", "Statistical Data Interpretation", "Surveys", "Testing", "Time", "TimeLine", "Tobacco use", "Visit", "Volatile Fatty Acids", "Work", "cardiovascular disorder risk", "cardiovascular risk factor", "cigarette smoking", "co-infection", "cohort", "comorbidity", "coronavirus disease", "cytisine", "cytokine", "design", "gut microbiome", "hazardous drinking", "high risk", "innate immune function", "intestinal fatty acid binding protein", "metabolic profile", "metabolome", "metabolomics", "microbial", "microbiome", "mortality risk", "nicotine replacement", "novel", "reduced alcohol use", "respiratory virus", "trial design", "varenicline" ], "approved": true } }, { "type": "Grant", "id": "6064", "attributes": { "award_id": "3U01AA020780-10S2", "title": "URBAN ARCH 4/5 Russia Cohort-Targeting HIV-comorbidities with Pharmacotherapy to Reduce Alcohol and Tobacco Use in HIV-infected Russians", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20670, "first_name": "Joe", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-09-20", "end_date": "2022-08-31", "award_amount": 147070, "principal_investigator": { "id": 20671, "first_name": "MATTHEW S", "last_name": "FREIBERG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1220, "ror": "https://ror.org/010b9wj87", "name": "Boston Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20672, "first_name": "JEFFREY H.", "last_name": "SAMET", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 20673, "first_name": "Hilary A", "last_name": "Tindle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1220, "ror": "https://ror.org/010b9wj87", "name": "Boston Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "HIV infected (HIV+) heavy drinking smokers are at high risk for coronary heart disease (CHD) and death. The mechanisms driving increased CHD risk in HIV+ people are unclear, but are linked to inflammation. HIV, heavy drinking, and smoking are all pro-inflammatory. HIV viral suppression with antiretroviral therapy does not eliminate the elevated CHD risk nor the increased inflammation (i.e., pre-HIV infection levels are not restored). Interventions that reduce alcohol use, smoking, or both in HIV+ people could lower inflammation, CHD and death risk. Varenicline and cytisine are proven therapies for smoking cessation. When compared to placebo, varenicline has higher cessation rates than cytisine. Human trials suggest varenicline also has efficacy for reducing alcohol consumption and craving in heavy drinking smokers. In murine models, cytisine reduces alcohol consumption. The comparative efficacy of varenicline and cytisine to reduce alcohol consumption and by extension, inflammation, CHD, and mortality risk, in humans has not been tested, nor has their comparative effectiveness been tested for smoking. Neither drug has been tested for smoking cessation against nicotine replacement therapy (NRT) in HIV+ heavy drinking smokers. Three compelling reasons to test varenicline and cytisine in HIV+ heavy drinking smokers are: 1) both show promise in HIV-uninfected people; 2) the morbidity caused by heavy drinking and smoking in HIV+ persons is significant; and 3) treating heavy drinking and smoking with one medication represents a significant advance in reducing polypharmacy and improving patient care. Thus, we propose a 4-arm placebo-controlled randomized controlled trial (RCT) among 400 HIV+ heavy drinking smokers. Trial arms are varenicline+NRT placebo, cytisine+NRT placebo, NRT+varenicline placebo, NRT+cytisine placebo. All participants will receive counseling (alcohol & tobacco) and medications (placebo & active). Our specific aims will compare effects of varenicline, cytisine, and NRT at 3 months on past month % heavy drinking days and alcohol craving, cigarettes per day and smoking abstinence (verified by carbon monoxide), inflammation (hsCRP, IL-6), CHD (Reynolds risk score), and mortality (VACS index) risk. We hypothesize that (1) Varenicline has greater efficacy than NRT for reducing heavy drinking, smoking, inflammation, CHD and mortality risk; (2) Cytisine has greater efficacy than NRT; and (3) Varenicline has greater efficacy than cytisine for these outcomes. We will conduct an RCT, Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians with HIV (St PETER HIV), in a country with an HIV epidemic and high per-capita alcohol consumption and smoking. We will recruit from our ongoing Russia ARCH cohort in St. Petersburg (part of our NIAAA funded HIV/AIDS Alcohol Consortium – URBAN ARCH). If our hypotheses are correct, St PETER HIV could make nicotinic partial-agonists standard care for HIV+ heavy drinking smokers, and lead to reduced inflammation, CHD and mortality risk through this “one drug, two diseases” approach. This trial addresses the paucity of RCT data to guide treatment of these CHD risk factors in HIV+ people.", "keywords": [ "AIDS/HIV problem", "Abstinence", "Address", "Agonist", "Alcohol consumption", "Alcoholic beverage heavy drinker", "Alcohols", "Automobile Driving", "Biochemical", "Biological Markers", "Blood Pressure", "Boston", "Carbon Monoxide", "Cardiovascular system", "Cessation of life", "Cigarette", "Cohort Studies", "Collaborations", "Coronary heart disease", "Counseling", "Country", "Data", "Disease", "Eastern Europe", "Epidemic", "Ethanol", "Funding", "Future", "HIV", "HIV Infections", "Heavy Drinking", "Human", "Inflammation", "Inflammatory", "Interleukin-6", "Intervention", "Intervention Studies", "Lead", "Link", "Monitor", "Morbidity - disease rate", "National Institute on Alcohol Abuse and Alcoholism", "Nicotine", "Nicotinic Receptors", "Outcome", "Participant", "Patient Care", "Patient Self-Report", "Persons", "Pharmaceutical Preparations", "Pharmacotherapy", "Placebos", "Polypharmacy", "Prevalence", "Randomized Controlled Trials", "Reporting", "Research", "Risk", "Risk Factors", "Russia", "Self Administration", "Side", "Smoke", "Smoker", "Smoking", "Testing", "Therapeutic Agents", "Tobacco", "Tobacco Use Cessation", "Tobacco use", "Uganda", "United States National Institutes of Health", "Viral", "alcohol craving", "alcohol research", "antiretroviral therapy", "arm", "base", "cohort", "comorbidity", "comparative", "comparative effectiveness", "comparative efficacy", "cost", "cytisine", "drinking", "evidence base", "heart disease risk", "high risk", "improved", "indexing", "mortality", "mortality risk", "mouse model", "neuropsychiatry", "nicotine replacement", "primary outcome", "recruit", "reduced alcohol use", "smoking abstinence", "smoking cessation", "standard care", "synthetic drug", "therapy outcome", "varenicline" ], "approved": true } }, { "type": "Grant", "id": "5639", "attributes": { "award_id": "3R01CA149105-10S1", "title": "Urban Revitalization and Long-Term Effects on Diet, Economic, and Health Outcomes", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 19509, "first_name": "Jill", "last_name": "Reedy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2010-05-14", "end_date": "2023-05-31", "award_amount": 196619, "principal_investigator": { "id": 19510, "first_name": "Tamara", "last_name": "Dubowitz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 515, "ror": "https://ror.org/00f2z7n96", "name": "RAND Corporation", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Food insecurity—a lack of consistent access to enough food for an active, healthy life—is a fundamental social determinant of health linked to poor nutrition, obesity, and chronic disease. During the initial months of the COVID-19 pandemic, existing racial inequities in food insecurity were exacerbated. Compared to an estimated increase of 60% in the U.S. general population, food insecurity increased nearly 80% among residents of two low-income African American food desert neighborhoods in Pittsburgh, Pennsylvania. Other data from our cohort as well as other studies suggests there were also substantial upticks in financial instability and mental health challenges as the pandemic and policy responses to it unfolded. We propose these three factors may be part of a syndemic (synergy of epidemics), i.e., that food insecurity, financial instability and mental distress may share similar causal roots, that they also influence one another, and that this process is exacerbated by disadvantage. Few scientific studies have longitudinal data with which to examine these factors. Our longitudinal cohort of low-income African Americans allows an opportunity to examine the health and economic impact of the pandemic. We propose analyses of our Pittsburgh Research on Neighborhood Change and Health (PHRESH) cohort data collected during three periods, including before and during the COVID-19 pandemic, to test these ideas. Specifically, our aims are to: (1) Examine the effects of the COVID-19 containment and mitigation efforts (shut downs, stay at home orders, school closings) on food security, financial stability, and mental health from pre-pandemic (2018) to its early months (Spring 2020), to more than one year following the U.S. outbreak (through mid-year 2021), testing for trends in these outcomes and how these trends are associated with one another. In addition, we will (2) test the extent to which pre-existing (2018) individual-level perceived (e.g., self-reported discrimination, low social status) and structural (neighborhood investments, improved socioeconomic conditions, walkability) inequities moderated pandemic impacts, buffering or exacerbating its influence on residents’ food security, financial stability and mental health.", "keywords": [ "Address", "Affect", "African American", "Buffers", "COVID-19", "COVID-19 pandemic", "Chronic Disease", "Communities", "Containment", "Data", "Development", "Diet", "Disadvantaged", "Discrimination", "Disease Outbreaks", "Distress", "Documentation", "Economics", "Epidemic", "Food", "Funding", "General Population", "Grant", "Health", "Health Policy", "Home", "Individual", "Intervention", "Investments", "Life", "Link", "Long-Term Effects", "Longitudinal Studies", "Longitudinal cohort", "Low income", "Mental Health", "Natural experiment", "Neighborhoods", "Nutritional", "Obesity", "Outcome", "Parents", "Patient Self-Report", "Pennsylvania", "Personal Satisfaction", "Plant Roots", "Policies", "Privatization", "Process", "Psyche structure", "Public Housing", "Research", "Risk", "Role", "Schools", "Series", "Services", "Social Distance", "Social status", "Structure", "Supermarket", "Testing", "Work", "base", "behavioral economics", "cohort", "economic impact", "epidemiology study", "experience", "food desert", "food insecurity", "food security", "health economics", "health inequalities", "improved", "marginalized population", "nutrition", "pandemic disease", "parent grant", "psychological distress", "resilience", "response", "social", "social health determinants", "socioeconomics", "synergism", "trend", "walkability" ], "approved": true } }, { "type": "Grant", "id": "4082", "attributes": { "award_id": "1560962", "title": "Urban Water Provisioning Systems and Household Water Security", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Geography and Spatial Sciences" ], "program_reference_codes": [], "program_officials": [], "start_date": "2016-06-01", "end_date": "2020-11-30", "award_amount": 254082, "principal_investigator": { "id": 13697, "first_name": "Wendy", "last_name": "Jepson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 342, "ror": "https://ror.org/01f5ytq51", "name": "Texas A&M University", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Water security remains a major challenge for rapidly growing urban areas of the developing world and impoverished areas in developed countries where unregulated and informal domestic water provisioning practices persist despite increases in household access to piped water. Urban water provision is an assemblage of water vendors, networked pipes, plastic jugs, standpipes, water meters, rainwater and greywater collection tanks, and water trucks that convey and manage domestic water provision to help households cope and meet needs of everyday life. This project examines how and why urban households obtain water through these hybrid infrastructure systems and tests their efficacy in terms of household water security, defined as reliable, adequate and affordable water for a healthy life, using a scaled metric developed by the investigator. The project will be conducted in metropolitan Fortaleza, Brazil, where domestic water provision reflects typical configurations of water provision in the developing world. Research outcomes will provide meaningful insights as to the benefits and limitations of hybrid water-provisioning systems and inform development interventions, technological innovations for water provision, and infrastructure investments. Investigators will create a publicly available online portal to disseminate project information and photos, research findings, and a computational tool to standardize the household water security metric for cross-regional comparisons, allowing researchers to examine impacts of household water insecurity on diverse areas such as public health and water infrastructure planning. The project will also deepen research networks between Brazilian and US researchers, broaden participation of underrepresented groups in science through its research design, and contribute to the development of a globally competitive STEM workforce by training one computer science undergraduate and one geography graduate student. \n\nThe emergence of regulated and unregulated water provisioning systems begs the question of its efficacy for human development and water security: Do hybrid urban water systems increase or decrease household water security? What particular configuration of formal and informal technologies and practices enhances or reduces household water security? How do different hybrid water-provisioning systems compare in terms of household water security? The major social scientific contribution of this project is to answer these questions by employing a mix of qualitative (observation; open-ended and semi-structured interviews), participatory (photovoice), and quantitative (survey) methods. The investigator will describe and develop a typology of water provision, assess how households interact with the existing systems, and measure household-level water security in selected urban communities. The household water security metric calculated from the survey data can be used to statistically test and model the relationship of water insecurity to several factors, including water-provisioning type, income, education, and health. This project will provide new empirical data to engage larger theoretical debates on the benefits of coexistence, the efficacy of centralized, piped water networks as the modern ideal of water provision, and urban water governance, more broadly.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1442, "count": 14420 } } }