Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=program_reference_codes
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=program_reference_codes", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=program_reference_codes", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=program_reference_codes", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=program_reference_codes" }, "data": [ { "type": "Grant", "id": "1482", "attributes": { "award_id": "2031756", "title": "RAPID: Mathematical Models for Understanding Key Epidemiological Parameters and Transmission of SARS-CoV-2", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)" ], "program_reference_codes": [ "096Z", "7914", "9150" ], "program_officials": [ { "id": 3851, "first_name": "Krastan", "last_name": "Blagoev", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2021-05-31", "award_amount": 200000, "principal_investigator": { "id": 3855, "first_name": "Alan", "last_name": "Perelson", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 606, "ror": "https://ror.org/01qnpp968", "name": "New Mexico Consortium", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 3852, "first_name": "Nicolas W", "last_name": "Hengartner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 3853, "first_name": "Ethan O", "last_name": "Romero-Severson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 3854, "first_name": "Ruian", "last_name": "Ke", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 606, "ror": "https://ror.org/01qnpp968", "name": "New Mexico Consortium", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic, caused by SARS-CoV-2, represents a true global emergency and crisis that needs to be addressed immediately. Currently we do not have a good understanding of quantitative estimates of key epidemiological parameters, such as the time from infection to becoming infectious, the duration of infectiousness, and how these durations are affected by symptom severity. We do not know how much transmission is driven by asymptomatic individuals and individuals with mild, moderate, or severe symptoms. Lastly, we do not know how the viral load relates to the infectiousness of an individual. By constructing multiscale models and integrating multiple streams of data from different biological scales into a coherent model framework, the project will address these unknowns through mathematical modeling and thus advance our understanding of COVID-19 transmission. This understanding will be then used to make precise predictions and evaluations of the impacts of interventions, i.e. much needed intellectual advancement to address the current COVID-19 global pandemic. The results of the project will be presented to public health professionals and government officials to aid decision making through regular meetings and connections that the team members participate and maintain. For example, co-PI Ke regularly participates in weekly CDC modeling group meetings and in monthly meetings with a working group commissioned by the White House called PPFST. Co-PIs Hengartner and Romero-Severnson have close connections with the New Mexico Department of Health. The PIs will ensure that the project is designed and formulated to address critical public health questions and that the results can be used by public health officials.The objective of this research project is to advance the fundamental understanding of key epidemiological parameters and determinants for SARS-CoV-2 that are essential to better quantify and predict SARS-CoV-2 transmission dynamics. The investigators will use mathematical modeling of SARS-CoV-2 dynamics across multiple scales. First, the PI will develop within-host models of SARS-CoV-2 infection and will fit the model to data from literature to estimate parameters such as the time from cell infection to release of virus into bodily fluids, the rate of viral production from infected cells, the infected cell lifespan, and other factors that link to transmission and disease severity. Another aim is to use the model to predict the effectiveness of drug therapy as a function of person's viral load. Second, the PI will tie the within-host dynamics to clinical factors, such as the time between infection and viral shedding, time to symptoms, and in some cases to time of death, which are important in understanding transmission dynamics and intervention effectiveness. Ultimately, this project will provide a quantitative framework to evaluate the effectiveness of pharmaceutical and non-pharmaceutical interventions, e.g., quarantine, school closures, and other means of social distancing.This grant is being awarded using funds made available by the Coronavirus Aid, Relief, and Economic Security (CARES) Act supplement allocated to MPS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1544", "attributes": { "award_id": "2031851", "title": "RAPID: Ethical Decision-Making about Conducting Essential Research in a Pandemic: Experiences of Principal Investigators and Research Personnel", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)" ], "program_reference_codes": [ "096Z", "7914", "9150" ], "program_officials": [ { "id": 4029, "first_name": "Wenda K.", "last_name": "Bauchspies", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-08-01", "end_date": "2021-09-30", "award_amount": 199388, "principal_investigator": { "id": 4031, "first_name": "Tristan", "last_name": "McIntosh", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 304, "ror": "", "name": "Washington University", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4030, "first_name": "Alison L", "last_name": "Antes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 304, "ror": "", "name": "Washington University", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has confronted researchers with unprecedented challenges. One of these challenges is the need to determine whether ongoing or new research projects are essential to conduct in-person during the crisis, and if so, which research personnel should conduct this research. Such decisions have been made all the more difficult by the challenges that plague them, including extreme time pressures, insufficient or vague guidance, competing personal and professional trade-offs, and uncertain ramifications for those affected by these decisions. A thorough understanding of the ethical and practical dimensions of these decisions is needed to help researchers and institutional officials better prepare for managing the scientific workforce during future crises. This project aims to understand how principal investigators have made these decisions during the current pandemic and identify the factors in their environments that shaped their decision-making, and how these decisions impact research personnel in their lab (e.g., graduate students, postdocs, technicians, staff scientists). Data from this project can help improve understanding about how principal investigators might approach challenging decision-making during similar future situations and how research personnel perceive and are affected by these decisions. Fostering enhanced awareness of and deepened appreciation for the unique challenges such emergencies pose to essential researchers will be valuable for researchers and the broader community that benefits from their work.This project addresses two primary research questions: 1) what ethical considerations and practical challenges shape principal investigators’ decision-making about whether and how to conduct in-person research projects during the COVID-19 pandemic?, and 2) how do research personnel ethically appraise their PI’s decisions and decision processes in light of their relationship and the context of the pandemic? Data collection will proceed using a mixed-methods approach to synthesize quantitative survey-based information from principal investigators and research personnel and interviews with select researchers, graduate students, and research staff. Initial surveys will be completed by hundreds of NSF- and NIH-funded scientists and research assistants, and follow-up interviews will be conducted with select participants. Data will then be synthesized, analyzed, and interpreted. Findings will be disseminated widely to benefit researchers in future emergencies. Answering these questions contributes to the research on ethical decision-making, ethical research cultures, research leadership, and pandemic policy-making.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1554", "attributes": { "award_id": "2031591", "title": "RAPID: Pandemic Anxiety, Recovery, and Inequality: Evaluating Institutions and Policy in a Coronavirus Hotspot", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)" ], "program_reference_codes": [ "096Z", "7914", "9150" ], "program_officials": [ { "id": 4056, "first_name": "Jan", "last_name": "Leighley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2021-05-31", "award_amount": 138613, "principal_investigator": { "id": 4058, "first_name": "Michael", "last_name": "Henderson", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 360, "ror": "https://ror.org/05ect4e57", "name": "Louisiana State University", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4057, "first_name": "Martin", "last_name": "Johnson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 360, "ror": "https://ror.org/05ect4e57", "name": "Louisiana State University", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic simultaneously unleashed health and economic threats on American society, each of which produces anxiety. Ultimately, recovery will require reintegration into the social and economic fabric after periods defined by quarantine and social distancing measures aimed at mitigating the spread of the virus. To what extent will experiences of anxiety in the face of these threats curb downstream recovery? The objective of this project is to understand experiences of anxiety and recovery among a representative sample of adults in Louisiana, a coronavirus hotspot whose COVID-19 mortality rate is one of the deadliest in the nation. The proposed study will also offer guidance to governing officials in how anxiety inhibits economic and health recovery even as the experiences of threat change. To measure the durability of anxiety and its effects on social trust and engagement, data will be collected in a four-wave representative panel of adult Louisiana residents using YouGov. The investigators will measure respondents’ exposure to the health and economic threats and their anxiety over them, as well as outcome variables including perceptions of progress of recovery; trust in institutions, leaders, and residents of their communities; civic, social, and economic activity; and support for policies aimed at mitigating threat impact or reopening the economy. The major contribution of this study will be to extend the scope of analysis from the immediate, short-run effects of anxiety to the long-run patterns by which anxiety persists and has downstream consequences for social and economic engagement, as well as deepen our understanding individual differences in how anxiety is associated with social and economic judgments.This project is jointly funded by the Accountable Institutions and Behavior (AIB) program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "2177", "attributes": { "award_id": "2027653", "title": "RAPID: Collaborative Research: COVID-19, Crises, and Support for the Rule of Law", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)" ], "program_reference_codes": [ "096Z", "7914", "9150" ], "program_officials": [ { "id": 5889, "first_name": "Reginald", "last_name": "Sheehan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-04-15", "end_date": "2021-03-31", "award_amount": 142850, "principal_investigator": { "id": 5890, "first_name": "Jay", "last_name": "Krehbiel", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 385, "ror": "", "name": "West Virginia University Research Corporation", "address": "", "city": "", "state": "WV", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 385, "ror": "", "name": "West Virginia University Research Corporation", "address": "", "city": "", "state": "WV", "zip": "", "country": "United States", "approved": true }, "abstract": "The rule of law is at the foundation of modern liberal democracy. Crises like the Coronavirus (COVID-19) pandemic, however, pose a challenge to this long-standing norm that buttresses modern democracies the world over. In the midst of a crisis, individuals' support for the rule of law is tested because their fundamental concern for the health, safety, and welfare of themselves, their families, and their friends is pitted against an abstract belief that the government “checks all the boxes” before carrying out potentially lifesaving policies. In these situations, one’s desire for decisive government action may overwhelm, and subsequently lead to a decline in, one’s commitment to abstract democratic principles like the rule of law. Consequently, evaluating how crises affect support for fundamental democratic norms is critical for understanding their impact on the health and stability of the liberal democratic order.This project leverages the COVID-19 outbreak to examine this relationship and determine (a) whether governmental responses to crises affect citizens’ support for the rule of law; (b) whether citizens’ faith in government efforts is buttressed or undermined in response to elite and expert cues; and (c) whether citizens’ attitudes change after a crisis has dissipated. Each of these theoretical aims is tied to one of three unique features of the research design, which relies upon surveys of European democracies. First, to examine the effects of governmental responses, the project will collect survey data on support for the rule of law across four Western democracies in April 2020: Germany, Spain, the United Kingdom, and the United States. Second, an original panel survey in Germany will enable the evaluation of changes to individual-level rule of law judgments in the short, medium, and long term. Lastly, embedded survey experiments will provide causal evidence on how elite and expert cues affect both the acceptance of policies and support for key aspects of the rule of law, such as compliance with laws and support for judicial constraints on executive and legislative power. Findings from each part of the project will provide insights into the individual-level dynamics crises activate in citizens’ relationship with democratic principles.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1597", "attributes": { "award_id": "2032153", "title": "RAPID: The potential of SARS-CoV2 to utilize the ACE2 receptor of domesticated and wild animals for cell entry.", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178" ], "program_officials": [ { "id": 4192, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-15", "end_date": "2021-08-31", "award_amount": 199594, "principal_investigator": { "id": 4195, "first_name": "Paul A", "last_name": "Rowley", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 627, "ror": "", "name": "Regents of the University of Idaho", "address": "", "city": "", "state": "ID", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4193, "first_name": "James T Van", "last_name": "Leuven", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 4194, "first_name": "Jagdish Suresh", "last_name": "Patel", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 627, "ror": "", "name": "Regents of the University of Idaho", "address": "", "city": "", "state": "ID", "zip": "", "country": "United States", "approved": true }, "abstract": "Zoonotic coronaviruses (CoVs) have caused two serious epidemics in humans (MERS-CoV and SARS-CoV) and the current COVID-19 pandemic (SARS-CoV2). There is evidence suggesting that although these CoVs originated from bats, other mammals could have been intermediate hosts that transmitted the virus to humans. Research supported by this award will help to identify animal populations that are likely susceptible to the current pandemic CoV (SARS-CoV2) and could potentially act as viral reservoirs and initiate new disease outbreaks. Determining the animal receptors that enable SARS-CoV2 cell entry will benefit both human and animal health by directing future studies of CoV tropism. This knowledge will also focus surveillance efforts to species most likely involved in zoonotic and reverse zoonotic transmission of SARS-CoV2 and other CoVs. This proposal will train undergraduate research students in computational and laboratory skills during the proposed project. Results from these studies will be published in peer-reviewed journals, presented at scientific meetings, posted to shared data repositories, and also shared through social media.Research supported by this award will employ computational modeling and empirical laboratory research to identify animal angiotensin converting-enzyme 2 (ACE2) cell receptors that confer susceptibility to SARS-CoV2. Researchers will test the hypothesis that certain amino acid residues in animal ACE2 are essential for coronavirus (CoV) spike protein interaction and cell entry. A computational pipeline will be developed to model and simulate the docking of the SARS-CoV2 receptor binding domain to the ACE2 cell receptor from hundreds of divergent animal species. We will also empirically test the capacity of SARS-CoV2 spike protein to utilize ACE2 through heterologous expressions systems and in vitro cell culture studies. The research has the potential to identify a wide spectrum of animal species that are susceptible to SARS-CoV2. This will aid in the understanding of the relationship between ACE2 genotype and SARS-CoV2 cell entry and allow the prediction of ACE2 residues that are critical for determining CoV susceptibility. This RAPID award is made by the Symbiosis, Defense, and Self-recognition Program in the BIO Division of Integrative Organismal Systems, and by the Established Program to Stimulate Competitive Research (EPSCoR), using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1922", "attributes": { "award_id": "2031761", "title": "RAPID: Collaborative Research: COVID-19, human milk and infant feeding", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178", "9179" ], "program_officials": [ { "id": 5101, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2022-05-31", "award_amount": 10000, "principal_investigator": { "id": 5102, "first_name": "Sylvia H", "last_name": "Ley", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 305, "ror": "https://ror.org/04vmvtb21", "name": "Tulane University", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 305, "ror": "https://ror.org/04vmvtb21", "name": "Tulane University", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has resulted in untold challenges to personal and public health, largely because scientists and clinicians know very little about the virus that causes it and how transmission occurs. Whereas respiratory droplets are known to be a major mode of transmission, it is very likely that there are other sources. One understudied possibility is transmission from mother to infant via breastfeeding. Although researchers know that some viruses can be passed from mother to infant in this fashion, almost nothing is known about SARS-CoV-2 (the virus that causes COVID-19). For this reason, there is substantial confusion as to whether breastfeeding is safe and/or beneficial when a mother is known to be infected. This study will provide fundamental information about this basic biological property of SARS-CoV-2, information that will be immediately usable by women, healthcare providers, and public policy makers. This study will investigate whether SARS-CoV-2 and anti-SARS-CoV-2 antibodies can be detected in breast milk produced by infected women. Results will provide needed information about potential spread of the disease between breastfeeding mothers and infants as compared to formula-feeding mothers and infants. This topic is urgent because women continue to give birth and breastfeed during the pandemic, and guidance is critically needed. The Broader Impacts of this project include both outreach to the public to inform breastfeeding mothers about breast-feeding choices, and education of an undergraduate and graduate student.Although respiratory droplets are a known source of SARS-CoV-2 transmission, other modes likely exist. One such possibility is SARS-CoV-2 vertical transmission during breastfeeding, but little is known about this type of transfer for any coronaviruses. For SARS-CoV-2, there are only a handful of studies that report analysis of milk produced by COVID-19+ women; all but three report no evidence of virus in milk. There is similarly limited research on the effects of maternal milk antibodies on infant immune responses and severity of symptoms. As a result, there is substantial confusion as to the risks and benefits of breastfeeding for SARS-CoV-2+ mothers. This proposed research is a longitudinal, repeated-measures study of 25 breastfeeding mothers and infants and 25 formula-feeding mothers and infants. Dyads will be recruited within 7 days of maternal COVID-19 diagnosis and followed for 2 months during which time milk and breast swabs will be repeatedly collected (from breastfeeding mothers) and analyzed for SARS-CoV-2 RNA using an RT-qPCR; milk will also be analyzed for SARS-CoV-2-specific antibodies. Stool samples will also be collected and analyzed to assess viral exposure/shedding; and dried blood spots collected and analyzed to assess viremia and antibody (IgG and IgA) titers. Results will immediately inform women, healthcare providers, and public policy makers regarding infant feeding choices during the postpartum period. This RAPID award is made by the Physiological and Structural Systems Cluster in the BIO Division of Integrative Organismal Systems, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1923", "attributes": { "award_id": "2031753", "title": "RAPID: Collaborative Research: COVID-19, human milk and infant feeding", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178", "9179" ], "program_officials": [ { "id": 5103, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2022-05-31", "award_amount": 101268, "principal_investigator": { "id": 5107, "first_name": "Michelle K", "last_name": "McGuire", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 627, "ror": "", "name": "Regents of the University of Idaho", "address": "", "city": "", "state": "ID", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 5104, "first_name": "Mark", "last_name": "McGuire", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 5105, "first_name": "Janet E", "last_name": "Williams", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 984, "ror": "https://ror.org/03hbp5t65", "name": "University of Idaho", "address": "", "city": "", "state": "ID", "zip": "", "country": "United States", "approved": true } ] }, { "id": 5106, "first_name": "Ryan M", "last_name": "Pace", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 627, "ror": "", "name": "Regents of the University of Idaho", "address": "", "city": "", "state": "ID", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has resulted in untold challenges to personal and public health, largely because scientists and clinicians know very little about the virus that causes it and how transmission occurs. Whereas respiratory droplets are known to be a major mode of transmission, it is very likely that there are other sources. One understudied possibility is transmission from mother to infant via breastfeeding. Although researchers know that some viruses can be passed from mother to infant in this fashion, almost nothing is known about SARS-CoV-2 (the virus that causes COVID-19). For this reason, there is substantial confusion as to whether breastfeeding is safe and/or beneficial when a mother is known to be infected. This study will provide fundamental information about this basic biological property of SARS-CoV-2, information that will be immediately usable by women, healthcare providers, and public policy makers. This study will investigate whether SARS-CoV-2 and anti-SARS-CoV-2 antibodies can be detected in breast milk produced by infected women. Results will provide needed information about potential spread of the disease between breastfeeding mothers and infants as compared to formula-feeding mothers and infants. This topic is urgent because women continue to give birth and breastfeed during the pandemic, and guidance is critically needed. The Broader Impacts of this project include both outreach to the public to inform breastfeeding mothers about breast-feeding choices, and education of an undergraduate and graduate student.Although respiratory droplets are a known source of SARS-CoV-2 transmission, other modes likely exist. One such possibility is SARS-CoV-2 vertical transmission during breastfeeding, but little is known about this type of transfer for any coronaviruses. For SARS-CoV-2, there are only a handful of studies that report analysis of milk produced by COVID-19+ women; all but three report no evidence of virus in milk. There is similarly limited research on the effects of maternal milk antibodies on infant immune responses and severity of symptoms. As a result, there is substantial confusion as to the risks and benefits of breastfeeding for SARS-CoV-2+ mothers. This proposed research is a longitudinal, repeated-measures study of 25 breastfeeding mothers and infants and 25 formula-feeding mothers and infants. Dyads will be recruited within 7 days of maternal COVID-19 diagnosis and followed for 2 months during which time milk and breast swabs will be repeatedly collected (from breastfeeding mothers) and analyzed for SARS-CoV-2 RNA using an RT-qPCR; milk will also be analyzed for SARS-CoV-2-specific antibodies. Stool samples will also be collected and analyzed to assess viral exposure/shedding; and dried blood spots collected and analyzed to assess viremia and antibody (IgG and IgA) titers. Results will immediately inform women, healthcare providers, and public policy makers regarding infant feeding choices during the postpartum period. This RAPID award is made by the Physiological and Structural Systems Cluster in the BIO Division of Integrative Organismal Systems, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1924", "attributes": { "award_id": "2031715", "title": "RAPID: Collaborative Research: COVID-19, human milk and infant feeding", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178", "9179" ], "program_officials": [ { "id": 5108, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2022-05-31", "award_amount": 53163, "principal_investigator": { "id": 5110, "first_name": "Courtney L", "last_name": "Meehan", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 306, "ror": "https://ror.org/05dk0ce17", "name": "Washington State University", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 5109, "first_name": "Celestina", "last_name": "Barbosa-Leiker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 306, "ror": "https://ror.org/05dk0ce17", "name": "Washington State University", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has resulted in untold challenges to personal and public health, largely because scientists and clinicians know very little about the virus that causes it and how transmission occurs. Whereas respiratory droplets are known to be a major mode of transmission, it is very likely that there are other sources. One understudied possibility is transmission from mother to infant via breastfeeding. Although researchers know that some viruses can be passed from mother to infant in this fashion, almost nothing is known about SARS-CoV-2 (the virus that causes COVID-19). For this reason, there is substantial confusion as to whether breastfeeding is safe and/or beneficial when a mother is known to be infected. This study will provide fundamental information about this basic biological property of SARS-CoV-2, information that will be immediately usable by women, healthcare providers, and public policy makers. This study will investigate whether SARS-CoV-2 and anti-SARS-CoV-2 antibodies can be detected in breast milk produced by infected women. Results will provide needed information about potential spread of the disease between breastfeeding mothers and infants as compared to formula-feeding mothers and infants. This topic is urgent because women continue to give birth and breastfeed during the pandemic, and guidance is critically needed. The Broader Impacts of this project include both outreach to the public to inform breastfeeding mothers about breast-feeding choices, and education of an undergraduate and graduate student.Although respiratory droplets are a known source of SARS-CoV-2 transmission, other modes likely exist. One such possibility is SARS-CoV-2 vertical transmission during breastfeeding, but little is known about this type of transfer for any coronaviruses. For SARS-CoV-2, there are only a handful of studies that report analysis of milk produced by COVID-19+ women; all but three report no evidence of virus in milk. There is similarly limited research on the effects of maternal milk antibodies on infant immune responses and severity of symptoms. As a result, there is substantial confusion as to the risks and benefits of breastfeeding for SARS-CoV-2+ mothers. This proposed research is a longitudinal, repeated-measures study of 25 breastfeeding mothers and infants and 25 formula-feeding mothers and infants. Dyads will be recruited within 7 days of maternal COVID-19 diagnosis and followed for 2 months during which time milk and breast swabs will be repeatedly collected (from breastfeeding mothers) and analyzed for SARS-CoV-2 RNA using an RT-qPCR; milk will also be analyzed for SARS-CoV-2-specific antibodies. Stool samples will also be collected and analyzed to assess viral exposure/shedding; and dried blood spots collected and analyzed to assess viremia and antibody (IgG and IgA) titers. Results will immediately inform women, healthcare providers, and public policy makers regarding infant feeding choices during the postpartum period. This RAPID award is made by the Physiological and Structural Systems Cluster in the BIO Division of Integrative Organismal Systems, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1931", "attributes": { "award_id": "2031888", "title": "RAPID: Collaborative Research: COVID-19, human milk and infant feeding", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178", "9179" ], "program_officials": [ { "id": 5127, "first_name": "Joanna", "last_name": "Shisler", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2022-05-31", "award_amount": 35563, "principal_investigator": { "id": 5130, "first_name": "Melanie A", "last_name": "Martin", "orcid": "https://orcid.org/0000-0003-0368-2791", "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": "['https://figshare.com/projects/Seattle_Mother-Infant_COVID-19_Study/84008']", "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 5128, "first_name": "Daniel", "last_name": "Eisenberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 5129, "first_name": "Eleanor", "last_name": "Brindle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has resulted in untold challenges to personal and public health, largely because scientists and clinicians know very little about the virus that causes it and how transmission occurs. Whereas respiratory droplets are known to be a major mode of transmission, it is very likely that there are other sources. One understudied possibility is transmission from mother to infant via breastfeeding. Although researchers know that some viruses can be passed from mother to infant in this fashion, almost nothing is known about SARS-CoV-2 (the virus that causes COVID-19). For this reason, there is substantial confusion as to whether breastfeeding is safe and/or beneficial when a mother is known to be infected. This study will provide fundamental information about this basic biological property of SARS-CoV-2, information that will be immediately usable by women, healthcare providers, and public policy makers. This study will investigate whether SARS-CoV-2 and anti-SARS-CoV-2 antibodies can be detected in breast milk produced by infected women. Results will provide needed information about potential spread of the disease between breastfeeding mothers and infants as compared to formula-feeding mothers and infants. This topic is urgent because women continue to give birth and breastfeed during the pandemic, and guidance is critically needed. The Broader Impacts of this project include both outreach to the public to inform breastfeeding mothers about breast-feeding choices, and education of an undergraduate and graduate student.Although respiratory droplets are a known source of SARS-CoV-2 transmission, other modes likely exist. One such possibility is SARS-CoV-2 vertical transmission during breastfeeding, but little is known about this type of transfer for any coronaviruses. For SARS-CoV-2, there are only a handful of studies that report analysis of milk produced by COVID-19+ women; all but three report no evidence of virus in milk. There is similarly limited research on the effects of maternal milk antibodies on infant immune responses and severity of symptoms. As a result, there is substantial confusion as to the risks and benefits of breastfeeding for SARS-CoV-2+ mothers. This proposed research is a longitudinal, repeated-measures study of 25 breastfeeding mothers and infants and 25 formula-feeding mothers and infants. Dyads will be recruited within 7 days of maternal COVID-19 diagnosis and followed for 2 months during which time milk and breast swabs will be repeatedly collected (from breastfeeding mothers) and analyzed for SARS-CoV-2 RNA using an RT-qPCR; milk will also be analyzed for SARS-CoV-2-specific antibodies. Stool samples will also be collected and analyzed to assess viral exposure/shedding; and dried blood spots collected and analyzed to assess viremia and antibody (IgG and IgA) titers. Results will immediately inform women, healthcare providers, and public policy makers regarding infant feeding choices during the postpartum period. This RAPID award is made by the Physiological and Structural Systems Cluster in the BIO Division of Integrative Organismal Systems, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "1533", "attributes": { "award_id": "2030037", "title": "Collaborative Research: RAPID: Spatial Modeling of Immune Response to Multifocal SARS-CoV-2 Viral Lung Infection", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)" ], "program_reference_codes": [ "096Z", "7914", "9150", "9178", "9179" ], "program_officials": [ { "id": 3999, "first_name": "Kathryn", "last_name": "Dickson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-01", "end_date": "2022-05-31", "award_amount": 130391, "principal_investigator": { "id": 4001, "first_name": "Melanie", "last_name": "Moses", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 170, "ror": "https://ror.org/05fs6jp91", "name": "University of New Mexico", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4000, "first_name": "Judy L", "last_name": "Cannon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 170, "ror": "https://ror.org/05fs6jp91", "name": "University of New Mexico", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 recently emerged as a worldwide pandemic, causing untold human suffering and severe economic disruptions. How individual immune systems respond to a novel coronavirus, for example, why some individuals clear infection efficiently while others do not is not known. This project seeks to understand how immune cells, specifically T cells, find cells infected with virus that are dispersed in the lung. It will address how spatial distributions of infected cells and movement patterns of T cells through complex lung structures determine the course of infection. The project will develop the Spatial Immunological Model of Coronavirus (SIM-Cov), a simulation model for studying these effects and improving understanding of how the immune system controls infection by coronaviruses. The model will take computed tomography (CT) scans of an infected human lung as input, as well as biological data on how T cells interact with the virus and infected lung cells. The model will predict the course of infection in the form of visually intuitive movies showing how the infection progresses through time in different individuals. By modeling variability in individuals’ infectious rates over time, SIM-Cov will improve our understanding of why the severity of COVID-19 varies so much among individuals. The model and movies will be publicly accessible, and incorporated into educational materials for high school and college students. The project will also train two graduate and one undergraduate students in interdisciplinary research.One gap in understanding infection dynamics of the novel coronavirus SARS-CoV-2 is why the severity of infection varies so much among individuals. This project addresses that gap by incorporating the role played by spatial-temporal dynamics in within-host infections and immune control, particularly the role of T cells which are required for viral clearance. Most quantitative models of viral infection use differential equations or stochastic models and do not account for the spatial distribution of infected cells or T cell movement patterns. The project addresses this gap by developing a three-dimensional spatial model of the whole lung (SIM-Cov) that tests how spatial interactions between T cells and virus affect viral growth, load and clearance within the lungs. Ultimately, these within-host factors contribute to the rate of clearance within a single host and transmission between hosts. SIM-Cov will be parameterized and validated with empirical imaging data (CT scans of SARS-infected patients) and the emerging literature on SARS-CoV-2 and immune responses. SIM-Cov will model the lung microenvironment, including vasculature and epithelium surrounding the airways and alveolar spaces, the spatial and temporal spread of virus throughout the lung, and the spatial arrangement and movement of T cells. The project will have broad-ranging impacts for understanding coronavirus infection dynamics and educational impacts through dissemination of the model and movies produced in the project, as well as the engagement of three students in interdisciplinary research.This RAPID award is made by the Physiological Mechanisms and Biomechanics Program and the Symbiosis, Defense, and Self-recognition Program in the BIO Division of Integrative Organismal Systems, and by the Established Program to Stimulate Competitive Research (EPSCoR), using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1424, "count": 14236 } } }