Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=-title
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-title", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1423&sort=-title", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=-title", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=-title" }, "data": [ { "type": "Grant", "id": "4822", "attributes": { "award_id": "1246432", "title": "4th Beneficial Microbes ConferenceSan Antonio, Tx, October 22 - 26, 2012", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Symbiosis Infection & Immunity" ], "program_reference_codes": [], "program_officials": [], "start_date": "2012-08-01", "end_date": "2013-07-31", "award_amount": 10000, "principal_investigator": { "id": 16745, "first_name": "Joerg", "last_name": "Graf", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1342, "ror": "https://ror.org/04xsjmh40", "name": "American Society for Microbiology", "address": "", "city": "", "state": "DC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1342, "ror": "https://ror.org/04xsjmh40", "name": "American Society for Microbiology", "address": "", "city": "", "state": "DC", "zip": "", "country": "United States", "approved": true }, "abstract": "The tremendous progress of high throughput technologies including DNA sequencing and proteomics is rapidly advancing the understanding of beneficial microbe-host interactions. Most animals and plants depend upon associations with coevolved communities of microorganisms that play critical roles in physiological balance and maintaining homeostasis. Recognition of these phenomena is revolutionizing how biologists view the function of the normal microbiota with respect to their association with hosts. The Beneficial Microbes Conference is unique in cutting across disciplines by bringing together ecologists, microbiologists, molecular biologists and computational biologists that have the common goal to understand the mechanisms and benefits of microbial interactions with a variety of hosts, from plants to humans. The conference will be held in San Antonio, Texas as a convenient central location in the United States. The aim is to provide a forum for increasing cross-disciplinary interactions and thus to develop new insights and approaches to the study of beneficial host-microbe interactions. This field is currently very popular as demonstrated by past scientist attendance to this conference series, including graduate students and postdoctoral researchers. To assure a broad representation, the organizational committee has well balanced demographic representation. One third of the invited speakers are junior (pre-tenure), and 6 of 19 invited speakers are women. Of the 36 contributed oral presentations, 17 (47%) will be selected from submitted abstracts, ensuring ample high-visibility for students and postdocs with innovative ideas. As in the previous meetings, the selection process for these student and postdoc presentations will focus on junior researchers, women and minorities. Students at underrepresented minority institutions will also be targets for support. The proposal budget includes 5 travel awards for minority graduate students, and the awardees will be selected based on the quality of their abstracts. Only poster presenters who are U.S. citizens will receive travel support.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6139", "attributes": { "award_id": "3R34DA050287-01S3", "title": "4:4 Investigation of opioid exposure and neurodevelopment (iOPEN)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20863, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 228933, "principal_investigator": { "id": 20864, "first_name": "Veerle", "last_name": "Bergink", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 20865, "first_name": "Moriah E", "last_name": "Thomason", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The SARS-CoV-2 (COVID-19) pandemic represents the most significant environmental event in living history. Sixty-eight million people worldwide have fallen ill to this disease, and 1.5 million people have died. Amongst those at greatest risk are society’s most vulnerable populations, including pregnant women and their children. It is unclear whether and how COVID-19 illness during pregnancy impacts the development of the child, as well as whether the timing of illness has any influence over this effect. It is also unknown whether environmental factors may mitigate observed outcomes. The present study will examine neurobehavioral trajectories in 100 children, half of whom will be born to women with COVID-19 infection diagnoses during pregnancy. Infants will undergo prospective longitudinal assessments at 1-, 6-, 9- and 12-months, including MRI 1 month (N = 50) and 12 months (N = 100). Our central hypotheses are that (1) perinatal COVID-19 leads to differences in infant attention, affect, myelination, and systems-level neural functional connectivity and that (2) earlier timing of prenatal infection and illness severity increase risk for developmental delay. We will explore specific environmental factors with potential influence over the association between maternal prenatal COVID-19 infection and child outcomes, particularly pre- and postnatal psychological health and partner support. We will thus be able to meaningfully evaluate whether, and how, prenatal COVID-19 illness modifies neurobehavioral development of infants and will address how variation in maternal psychobiological health influences observed associations.", "keywords": [ "2019-nCoV", "Address", "Affect", "Age", "Attention", "Baseline Surveys", "Behavioral", "Biological Factors", "Birth", "Brain", "COVID-19", "COVID-19 diagnosis", "COVID-19 pandemic", "Cessation of life", "Child", "Child Development", "Classification", "Clinical Management", "Coronavirus", "Country", "Data", "Data Collection", "Development", "Developmental Delay Disorders", "Diagnosis", "Disease", "Emotional", "Environment", "Environmental Risk Factor", "Event", "Exposure to", "Fetal Distress", "Goals", "Health", "Health behavior", "Human", "Human Development", "Incidence", "Income", "Individual", "Individual Differences", "Infant", "Infant Development", "Infection", "Inflammation", "Infrastructure", "Investigation", "Life", "Magnetic Resonance Imaging", "Measures", "Mental Health", "Mothers", "Myelin", "Neurocognitive", "New York City", "Newborn Infant", "Outcome", "Outcome Measure", "Outcome Study", "Perinatal", "Population", "Pregnancy", "Pregnant Women", "Premature Labor", "Protocols documentation", "Psychosocial Factor", "Psychosocial Stress", "Public Health", "Receiver Operating Characteristics", "Recording of previous events", "Reporting", "Research", "Research Personnel", "Risk", "Risk Factors", "SARS-CoV-2 infection", "Series", "Severity of illness", "Societies", "Stress", "Surveys", "System", "Testing", "Third Pregnancy Trimester", "United States National Institutes of Health", "Validation", "Variant", "Vertical Disease Transmission", "Vulnerable Populations", "Water", "Woman", "Work", "antenatal", "caregiving", "cohort", "contextual factors", "experience", "high dimensionality", "in utero", "infancy", "infant outcome", "multimodality", "myelination", "negative affect", "neurobehavioral", "neurodevelopment", "novel", "offspring", "opioid exposure", "pandemic disease", "postnatal", "pregnant", "prenatal", "prospective", "protective factors", "psychobiologic", "recruit", "relating to nervous system", "repository", "resilience", "sex", "tool" ], "approved": true } }, { "type": "Grant", "id": "4859", "attributes": { "award_id": "1055082", "title": "45th Annual Spring Topology and Dynamical Systems Conference", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "TOPOLOGY" ], "program_reference_codes": [], "program_officials": [ { "id": 16879, "first_name": "Joanna", "last_name": "Kania-Bartoszynska", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2011-01-15", "end_date": "2011-12-31", "award_amount": 49556, "principal_investigator": { "id": 16880, "first_name": "Sheldon", "last_name": "Davis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1349, "ror": "", "name": "University of Texas at Tyler", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1349, "ror": "", "name": "University of Texas at Tyler", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "The 45th Annual Spring Topology and Dynamical Systems Conference will be held at the University of Texas at Tyler from Thursday March 17 through Saturday March 19, 2011. The conference will offer special sessions in Continuum Theory, Dynamical Systems, Geometric Group Theory, Geometric Topology, and Set-theoretic Topology, as well as six plenary talks and 12 semi-plenary talks covering the breadth of the special sessions. The conference is organized by the special session organizing committees, the conference steering committee, and the principal investigator on the grant. The grant provides funds to support travel for graduate students and young researchers, in addition to the invited speakers.\n \nThe series of conferences is one of the longest running in mathematics. In the spring of 1967, the first conference was held at Arizona State University, and it was primarily a conference on general topology and continuum theory. In the past 45 years, the conference has grown in size and scope. It has continued to be the most important conference of the year in set-theoretic topology and continuum theory, while expanding to include the areas of dynamical systems, geometric group theory, and geometric topology. Over the years, the conference has made special efforts to broaden participation by women, underrepresented groups, graduate students, and young researchers, while expanding to cover a broader section of topology. Many of the most famous results of the last 45 years have been first announced at this conference.\n\nConference website: http://www.math.uttyler.edu/sgraves/STDC2011/Welcome.html", "keywords": [], "approved": true } }, { "type": "Grant", "id": "4720", "attributes": { "award_id": "1256700", "title": "43rd Linguistic Symposium on Romance Languages: Special Session on Romance Parsed Corpora-New York City - April, 2013", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Linguistics" ], "program_reference_codes": [], "program_officials": [ { "id": 16364, "first_name": "Joan", "last_name": "Maling", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2013-03-01", "end_date": "2014-02-28", "award_amount": 13796, "principal_investigator": { "id": 16365, "first_name": "Christina", "last_name": "Tortora", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1143, "ror": "", "name": "CUNY College of Staten Island", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1143, "ror": "", "name": "CUNY College of Staten Island", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The principal object of study for a core area of Linguistics is the individual speaker's knowledge of his/her native language, or \"grammar.\" Given that a speaker's knowledge of grammar is unconscious, a challenge for the discipline is to develop reliable methodologies that uncover the right data and enhance replicability. \"Parsed corpora\" projects are an important component in an emerging methodology being used to uncover the syntactic patterns underlying speakers' use of language. These are texts, both written and spoken, which are annotated with detailed grammatical information, and then used as tools to test hypotheses about statistical tendencies in syntactic patterning. While there is a rapidly growing body of Germanic parsed corpora in the discipline, there have been equally important developments in parsed corpora in Romance.\n\nWith support from the National Science Foundation, a \"Special Session on Parsed Corpora of Romance languages\" will be held at the 43rd Linguistic Symposium on Romance Languages (LSRL43), April 17-19, 2013, at The Graduate Center of The City University of New York. As the largest annual gathering of linguists working on Romance languages, the LSRL affords the perfect occasion to make the Romance linguistics community aware of some of the most exciting recent advances in syntax, which are based on these innovative tools. The objective is to provide a focused discussion of how these parsed corpora can be used as tools by anyone in the discipline, and to thereby foster scientific activity. The Session will include three one-hour talks on both historical and synchronic parsed corpora in Romance languages: (1) the \"Modelling Change: The Paths of French\" corpus, presented by Anthony Kroch and Beatrice Santorini (University of Pennsylvania), (2) the \"Syntax-oriented corpus of Portuguese dialects,\" presented by Ana Maria Martins (University of Lisbon), and (3) the \"Tycho Brahe Parsed Corpus of Historical Portuguese,\" presented by Charlotte Galves (University of Campinas).", "keywords": [], "approved": true } }, { "type": "Grant", "id": "7339", "attributes": { "award_id": "3R34DA050290-01S2", "title": "4/7: Longitudinal Evaluation of the Impact of the COVID-19 Pandemic on High-risk New and Expectant Mothers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 158349, "principal_investigator": { "id": 22880, "first_name": "Elizabeth E", "last_name": "Krans", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23130, "first_name": "BEATRIZ", "last_name": "LUNA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] }, { "id": 23131, "first_name": "Ashok", "last_name": "Panigrahy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "While the rate of neonatal abstinence syndrome has reached a staggering 6.5 per 1,000 births nationwide, the short- and long-term effects of in-utero opioid exposure are far from clear. We lack fundamental knowledge of neurotypical neonatal development and struggle to disentangle the effect of opioid exposure from other protective and risk factors impacting infant health. The fetal stage of brain development is a critical period when foundational aspects of brain structure and function are being established. In addition, postnatal brain development and specialization are shaped by environmental experiences thus allowing maturation to be influenced by lifestyle factors associated with opioid use. This Phase I project will plan for a large scale, multi- site research study to prospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally through childhood. The University of Pittsburgh is one of four linked sites including Oregon Health and Sciences University, New York University and the University of Vermont that will address key challenges critical to the success of the planned Phase II study. Aim 1 will develop, implement and evaluate innovative recruitment and retention strategies for high-risk populations through a longitudinal survey of 150 pregnant women per site (n=600 across sites), half of whom are opioid using. Aim 2 will implement a multi-site, standardized, longitudinal research protocol by enrolling 20 pregnant women per site (n=80 across sites), half of whom are opioid using. This prospective longitudinal study will collect fetal and neonatal multimodal MRI, biospecimens, and maternal psychosocial and health assessments. Aim 3 will evaluate data acquisition, processing, and statistical considerations to maximize data quality, usability, and integration across sites. We will test the efficacy of (A) real-time motion monitoring/quality assessment for improving overall data quality and (B) time-savings versus MRI quality using new acceleration sequence protocols. This approach will inform and set a strong foundation for a comprehensive and effective Phase II research plan. The University of Pittsburgh site is led by a highly productive, NIH-funded investigative team with multidisciplinary expertise in substance use (Krans, Bogen), pregnancy (Krans), and fetal, neonatal, and pediatric neuroimaging (Luna, Panigrahy). Specifically, our team has established study protocols that yield excellent recruitment (~76%) and retention (~74%) rates among opioid using pregnant women, has substantial experience with imaging the immature brain (fetal/neonatal) and is a leader in developmental cognitive neuroscience using multimodal imaging to investigate neural mechanisms underlying neurocognitive development through adolescence. We will leverage our on-going, NIH-funded, multi-center neuroimaging studies to provide imaging harmonization techniques and assist with the development of structural fetal brain and placental imaging pipeline for all linked sites to assistant with development of Phase II protocol. Further, we will pilot innovative studies of age-related Iron deposition and quantitative fetal MR spectroscopy.", "keywords": [ "Acceleration", "Address", "Adolescence", "Alcohol or Other Drugs use", "Apgar Score", "Behavioral", "Biological", "Biological Specimen Banks", "Biology", "Birth", "Birth Records", "Brain", "COVID-19", "COVID-19 pandemic", "Caring", "Child", "Child Health", "Child Rearing", "Childhood", "Cognitive", "Collection", "Communities", "Coping Behavior", "Data", "Data Set", "Deposition", "Development", "Developmental Delay Disorders", "Economics", "Emotional", "Enrollment", "Equation", "Event", "Exposure to", "Factor Analysis", "Fetal Structures", "Foundations", "Funding", "Future", "Gene Expression", "Geographic Locations", "Geography", "Gestational Age", "Health", "Health Sciences", "Healthcare", "Human", "Human Development", "Image", "Impact evaluation", "Individual", "Infant", "Infant Health", "Institution", "Intervention", "Iron", "Knowledge", "Life", "Link", "Local Government", "Long-Term Effects", "Longitudinal Surveys", "Longitudinal prospective study", "Low Birth Weight Infant", "Magnetic Resonance Imaging", "Magnetic Resonance Spectroscopy", "Medical Economics", "Medical center", "Mental Health", "Modeling", "Monitor", "Mothers", "Motion", "Multimodal Imaging", "Neonatal", "Neonatal Abstinence Syndrome", "Neurocognitive", "New York", "Oregon", "Outcome", "Parents", "Perinatal", "Phase", "Phase II Clinical Trials", "Policies", "Postpartum Period", "Postpartum Women", "Predisposition", "Pregnancy", "Pregnant Women", "Protocols documentation", "Proxy", "Psychological Stress", "Psychosocial Assessment and Care", "Recording of previous events", "Research", "Resources", "Risk", "Risk Factors", "Sampling", "Savings", "Severities", "Site", "Social support", "Specimen", "Standardization", "Stress", "Structure", "Surveys", "Techniques", "Testing", "Time", "Uncertainty", "United States National Institutes of Health", "Universities", "Variant", "Vermont", "Viral", "Virus", "Vulnerable Populations", "Washington", "Woman", "Work", "age related", "behavioral health", "brain health", "cognitive development", "cognitive neuroscience", "cohort", "contextual factors", "coping", "coronavirus disease", "critical period", "data acquisition", "data quality", "efficacy testing", "experience", "fetal", "health assessment", "health economics", "high risk", "high risk population", "improved", "in utero", "indexing", "individual variation", "infant temperament", "inflammatory marker", "innovation", "interest", "lifestyle factors", "mat" ], "approved": true } }, { "type": "Grant", "id": "6365", "attributes": { "award_id": "3R34DA050341-01S2", "title": "4/6 Planning for the HEALthy Early Development Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 21446, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 228033, "principal_investigator": { "id": 21447, "first_name": "CHRISTINA", "last_name": "CHAMBERS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 760, "ror": "https://ror.org/0168r3w48", "name": "University of California, San Diego", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.", "keywords": [ "2019-nCoV", "Address", "Administrative Supplement", "Affect", "Age", "Alcohol or Other Drugs use", "Antibodies", "Anxiety", "Area", "Behavior", "Behavioral", "Birth Weight", "Brain", "COVID-19", "Canada", "Child", "Child Development", "Clinical Research", "Cognitive", "Cohort Studies", "Collection", "Congenital Abnormality", "Consent", "Data", "Data Analyses", "Development", "Emotional", "Enrollment", "Ethics", "Event", "Exposure to", "Family", "Fright", "Funding", "Future", "Goals", "Grant", "Growth and Development function", "Health", "Health Status", "Health behavior", "Human", "Individual", "Infant", "Infection", "Infrastructure", "Interview", "Knowledge", "Life", "Link", "Longitudinal Studies", "Maternal Health", "Measures", "Medical", "Medical Records", "Mental Depression", "Mental Health", "Newborn Infant", "Participant", "Pattern", "Phase", "Population", "Pregnancy", "Pregnancy Outcome", "Pregnancy loss", "Pregnant Women", "Premature Birth", "Protocols documentation", "Recommendation", "Research", "Research Personnel", "Safety", "Sampling", "Site", "Social Impacts", "Stress", "Symptoms", "Test Result", "Testing", "Time", "Virus", "Visit", "Vulnerable Populations", "Woman", "Women&apos", "s Health", "Work", "care outcomes", "design", "disorder risk", "early childhood", "economic impact", "experience", "follow-up", "high risk", "innovative technologies", "neuroimaging", "new technology", "offspring", "pandemic disease", "phase 2 study", "postnatal", "pregnant", "prenatal", "prenatal testing", "prospective", "recruit", "reproductive", "research study", "social", "stressor", "uptake", "working group" ], "approved": true } }, { "type": "Grant", "id": "5974", "attributes": { "award_id": "3R34DA050289-01S3", "title": "4/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes (Administrative Supplement)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 20444, "first_name": "Janani", "last_name": "Prabhakar", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2022-03-31", "award_amount": 193936, "principal_investigator": { "id": 20445, "first_name": "CHARLES Alexander", "last_name": "NELSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 798, "ror": "https://ror.org/00dvg7y05", "name": "Boston Children's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Over a year into the global pandemic, COVID-19 poses serious threats to physical health and emotional well-being. Pregnant women are at risk for serious morbidity due to COVID-19 and may be particularly vulnerable to psychological distress, compounded by continued social isolation, financial insecurity, and uncertainty about their own health, as well as that of their unborn child. To date, 73,617 pregnant women in the U.S. have tested positive for COVID-19. Understanding how prenatal exposure to COVID-19 and associated stress impact the developing fetus is of critical relevance to public health. Prenatal exposure to maternal infection and related stress has been strongly associated with disrupted child neurodevelopment. Although risk for vertical transmission of COVID-19 is low (Golden & Simmons, 2020), maternal immune activation is a potential mechanism by which prenatal exposure to infection can impact neurodevelopment. Epidemiological studies have revealed that maternal infections during pregnancy are linked to higher incidence of autism, schizophrenia, and central nervous system disorders (e.g., cerebral palsy) among offspring (Solek et al., 2018; Knuesel et al., 2014; Bauman & Van de Water, 2020). Animal models suggest that maternal immune activation can alter fetal brain development, increasing neurodevelopmental risk (Bergdolt & Dunaevsky, 2019). Effects of maternal stressors are observed at multiple levels, including disrupted brain maturation, epigenetic alterations, and poor developmental outcomes among offspring (Bick & Nelson, 2016; Nelson, 2020; Lupien et al., 2019; McEwen, 2012, 2017; Vanderberg et al., 2017; Wu et al., 2020). Cumulative effects of prenatal infection and stress may exacerbate neuropsychiatric risk: for example, mothers who experienced an infection and elevated stress during pregnancy are more likely to have adolescent offspring with depression (Murphy et al., 2017). To inform effective interventions, it is critical to examine whether–– and how–– maternal COVID-19 exposure and related stress affect infant neurodevelopment. At Boston Children's Hospital (BCH), we are ideally positioned to build on current funding (R34 DA050289) and an approved IRB protocol (IRB-P00035929) to perform neurodevelopmental follow-up of infants born to COVID-19-positive women, enrolled in the Massachusetts General Hospital (MGH) COVID-19 Pregnancy Biorepository (PI: Edlow). In the next 6 months, we will enroll 60 mother-infant dyads from this large cohort to participate in two visits at the PI's BCH lab (ages 9 and 12 months). At each visit, we will conduct study procedures assessing maternal stress, neurophysiology (EEG, eyetracking), and developmental outcomes. A subset of participants will complete an MRI at 9 months.", "keywords": [ "Administrative Supplement", "Affect", "Age", "Age-Months", "Animal Model", "Boston", "Brain", "COVID-19", "COVID-19 diagnosis", "COVID-19 pandemic", "Case Study", "Cells", "Central Nervous System Diseases", "Cerebral Palsy", "Child", "Child Health", "Coronavirus", "Data", "Development", "Electroencephalography", "Enrollment", "Environmental Risk Factor", "Epigenetic Process", "Event", "Exposure to", "Fetal Development", "Funding", "General Hospitals", "Grant", "Health", "Imaging Device", "Immune", "Immunologic Markers", "Incidence", "Infant", "Infant Development", "Infection", "Inflammation", "Institutional Review Boards", "Language", "Learning", "Life", "Link", "Magnetic Resonance Imaging", "Massachusetts", "Maternal Exposure", "Measures", "Mental Depression", "Microglia", "Modeling", "Morbidity - disease rate", "Mother-Child Relations", "Mothers", "Motor Skills", "Opioid", "Outcome", "Parents", "Participant", "Pathway interactions", "Pattern", "Pediatric Hospitals", "Perinatal", "Physiological", "Population", "Positioning Attribute", "Postpartum Depression", "Pregnancy", "Pregnant Women", "Procedures", "Protocols documentation", "Psychosocial Stress", "Public Health", "Questionnaires", "Rest", "Risk", "SARS-CoV-2 infection", "SARS-CoV-2 positive", "SARS-CoV-2 transmission", "Scanning", "Schizophrenia", "Shapes", "Social isolation", "Stress", "Structure", "Surveys", "System", "Testing", "Umbilical Cord Blood", "Uncertainty", "Vertical Disease Transmission", "Visit", "Visual", "Water", "Well in self", "Woman", "Zika Virus", "adolescent offspring", "autism spectrum disorder", "behavior measurement", "biobank", "cohort", "comparison group", "congenital zika syndrome", "early life adversity", "effective intervention", "epidemiology study", "experience", "fetal", "follow-up", "immune activation", "indexing", "infant outcome", "inflammatory marker", "language outcome", "maternal stress", "morphometry", "neonate", "neural growth", "neural network", "neurodevelopment", "neurophysiology", "neuropsychiatry", "non-invasive imaging", "novel", "offspring", "pandemic disease", "parent grant", "parent project", "perceived stress", "physical conditioning", "prenatal", "prenatal exposure", "primary outcome", "prisma", "psychologic", "psychological distress", "recruit", "relating to nervous system", "resilience", "response", "stressor", "unborn child", "visual tracking", "white matter" ], "approved": true } }, { "type": "Grant", "id": "7310", "attributes": { "award_id": "3R34DA050289-01S2", "title": "4/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 196414, "principal_investigator": { "id": 12932, "first_name": "CHARLES Alexander", "last_name": "NELSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 798, "ror": "https://ror.org/00dvg7y05", "name": "Boston Children's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 798, "ror": "https://ror.org/00dvg7y05", "name": "Boston Children's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Beyond the grave health threats posed by COVID-19, this world-wide pandemic has also dramatically increased psychological distress among much of the population. For those particularly vulnerable to stress-related disorders, COVID-19 represents an unprecedented challenge. Individuals both directly and indirectly affected by the virus are forced to navigate through a range of hardships, including social isolation, financial insecurity, and uncertainty about the health and safety of self and loved ones. High on the list of psychologically vulnerable groups are pregnant women. Psychological distress may be compounded both by the uncertainty surrounding COVID-19's vertical transmission and by the potential effects of maternal distress on fetal brain development. Numerous studies have reported strong associations between maternal stress during pregnancy and disruptions in child development. The effects of maternal psychological stressors on fetal and infant development have been demonstrated across multiple levels, including disrupted fetal brain maturation, alterations in miRNA expression and DNA methylation, and increased risks for altered developmental outcomes and neuropsychiatric disorders (Babenko, 2015; Bick & Nelson, 2016; Hackman et al., 2010; Nelson, 2020; Lupien et al., 2019; McEwen, 2012, 2017; Vanderberg et al., 2017; Laplante et al., 2015; Wu et al., 2020). Previous work supports that mothers who experienced either a bacterial or viral infection and elevated stress during pregnancy were more likely to have an adolescent child diagnosed with depression (Murphy et al., 2017). Similarly, children exposed to a prenatal infection of the 2001 H1N1 virus displayed slightly delayed development (Borren et al, 2018).With these findings in mind, it is critical to determine the extent to which a COVID-19 exposure and related prenatal stress affects infant development in order to provide appropriate treatment and interventions. At Boston Children's Hospital, we are in the unique position to build on our current funding (R34 DA050289) to study infants born to COVID-19-positive women. Among our Boston-based collaborative group, we estimate that over the next 6 months we should be able to enroll 75 pregnant women, limiting ourselves to just one Harvard-affiliated hospital, Brigham and Women's Hospital (BWH). Our plan is to administer a number of questionnaires to these women prior to giving birth. At birth, we will work with the OB team to decide which mothers to approach about seeking consent to perform an MRI on their newborns, as well as 2 follow up visits to the PI's lab at Boston Children's Hospital.", "keywords": [ "Adolescent", "Affect", "Age-Months", "Amygdaloid structure", "Animal Model", "Animal Testing", "Antibodies", "Bacterial Infections", "Birth", "Boston", "Brain", "COVID-19", "COVID-19 pandemic", "Child", "Child Development", "Child Health", "Childhood", "Clinical", "Cognition", "Cognitive", "Consent", "Consequentialism", "Contracts", "DNA Methylation", "DSM-V", "Development", "Diagnosis", "Diffusion Magnetic Resonance Imaging", "Distress", "Electroencephalography", "Enrollment", "Environment", "Epigenetic Process", "Event", "Exposure to", "Fetal Development", "Frequencies", "Funding", "Goals", "Grant", "Head", "Health", "Hippocampus (Brain)", "Hospitals", "Human", "Ice", "Individual", "Infant", "Infant Development", "Infection", "Inflammation", "Influenza A Virus H1N1 Subtype", "Intervention", "Interview", "Language", "Learning", "Life", "Linguistics", "Longitudinal Studies", "Magnetic Resonance Imaging", "Maternal Health", "Measures", "Mediating", "Medicine", "Mental Depression", "Mental Health", "Metabolic", "MicroRNAs", "Mind", "Modification", "Mothers", "Motor", "Natural Disasters", "Near-Infrared Spectroscopy", "Neonatal", "Newborn Infant", "Opioid", "Outcome", "Outcome Measure", "Patient Self-Report", "Pattern", "Pediatric Hospitals", "Pediatrics", "Perinatal", "Physiological", "Play", "Population", "Positioning Attribute", "Predisposition", "Pregnancy", "Pregnant Women", "Prevalence", "Psychopathology", "Quebec", "Questionnaires", "Radiology Specialty", "Reporting", "Resolution", "Rest", "Risk", "Role", "Safety", "Sampling", "Scanning", "Science", "Social isolation", "Standardization", "Stress", "Structure", "Symptoms", "System", "Testing", "Thick", "Third Pregnancy Trimester", "Trauma", "Uncertainty", "United States", "Vertical Disease Transmission", "Virus", "Virus Diseases", "Visit", "Visual", "Visual evoked cortical potential", "Vulnerable Populations", "Woman", "Work", "Zika Virus", "autism spectrum disorder", "base", "behavior measurement", "cognitive ability", "cognitive function", "early childhood", "early life adversity", "experience", "fetal", "follow-up", "high risk", "immune function", "infancy", "infant outcome", "language outcome", "loved ones", "magnetic resonance imaging/electroencephalography", "maternal depression", "maternal stress", "medical schools", "morphometry", "neonatal period", "neural network", "neurodevelopment", "neuroimaging", "neuropsychiatric disorder", "offspring", "pandemic di" ], "approved": true } }, { "type": "Grant", "id": "7275", "attributes": { "award_id": "3R34DA050268-01S2", "title": "4/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 169281, "principal_investigator": { "id": 23070, "first_name": "STEPHANIE L", "last_name": "MERHAR", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23071, "first_name": "JENNIFER J.", "last_name": "VANNEST", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has affected the mental and physical health of children and their parents. The pandemic has also affected the ability to conduct in-person research at most institutions across the United States. However, recent technological advances may allow many in-person assessments to transition to virtual formats. There is an urgent need to develop virtual versions of currently used assessments of the home environment and parent-child interactions, and to concurrently study the effect of the COVID-19 pandemic on family relationships. The proposed project seeks to address this urgent need by building upon ongoing research efforts among three sites from the NIH HEALthy Brains and Cognitive Development (HBCD) study: Arkansas Children’s Research Institute, Cincinnati Children’s Hospital, and the University of North Carolina at Chapel Hill. We will develop and test a virtual version of the HOME Inventory in 90 mothers with infants between 6-18 months of age. We will validate this virtual version by performing in-person HOME Inventory assessments in 45 of these dyads. In all participants, we will use standard questionnaires to assess COVID-19 exposure and impact. Finally, we will examine associations between regional and temporal variations in COVID-19 exposure and impact and dimensions of the HOME Inventory. The results of this study will be used to finalize the development of a virtual HOME Inventory protocol that can be widely used in future studies, including the HBCD Phase II study.", "keywords": [ "Address", "Adult", "Affect", "Age-Months", "Anxiety", "Arkansas", "Behavior", "Brain", "COVID-19", "COVID-19 pandemic", "Child", "Child Development", "Child Health", "Child Rearing", "Cognitive", "Cohort Studies", "Development", "Dimensions", "Environment", "Equipment", "Equipment and supply inventories", "Family", "Family Relationship", "Future", "Geography", "Home environment", "Individual", "Infant", "Infection", "Institution", "Manuals", "Measurement", "Measures", "Mental Health", "Mothers", "North Carolina", "Parent-Child Relations", "Parents", "Participant", "Pediatric Hospitals", "Perinatal", "Persons", "Phase", "Protocols documentation", "Psychometrics", "Questionnaires", "Research", "Research Institute", "Safety", "Schools", "Site", "Stress", "Surveys", "Testing", "Time", "Training", "Transcend", "Uncertainty", "United States", "United States National Institutes of Health", "Universities", "Validation", "Variant", "Visit", "cognitive development", "cost", "experience", "innovation", "learning materials", "pandemic disease", "phase 1 study", "phase 2 study", "physical conditioning", "social", "virtual" ], "approved": true } }, { "type": "Grant", "id": "15698", "attributes": { "award_id": "4R44AI179588-02", "title": "3STEP: A swab-seal-read assay for tuberculosis and RIF resistance enabled by autonomous extraction technology", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32562, "first_name": "KAREN A", "last_name": "LACOURCIERE", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-07-03", "end_date": "2027-06-30", "award_amount": 1000000, "principal_investigator": { "id": 31601, "first_name": "Jay Wyatt", "last_name": "Warrick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2509, "ror": "", "name": "SALUS DISCOVERY, LLC", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "In 2021 there were 10.6 million new cases of Mycobacterium tuberculosis (TB) and 1.6 million TB-related deaths, making TB the second leading infectious cause of death worldwide behind only COVID-19. Standard TB diagnostic methods are insufficient in that they either 1) utilize challenging sample types and are often invasive (e.g., sputum, gastric aspiration, lymph node biopsy), 2) lack sufficient sensitivity and/or specificity (e.g., culture, reliance on clinical observation alone), or 3) cannot be widely implemented in community point-of-care (POC) settings. As a result, there remains a significant unmet need for affordable POC technologies that can be used at local or temporary clinics, urgent care facilities, pharmacies, and school health clinics with easier to acquire samples (e.g., urine or oral swabs). In addition, TB is notoriously difficult to lyse adding another challenge to the creation of a POC solution. Salus Discovery has developed 3STEP, a new LAMP-based POC NAT for TB that directly overcomes the above mentioned challenges. 3STEP provides lab-quality, PCR sensitivity (<10 CFU/swab analytical sensitivity) with the speed and simplicity of a lateral flow assay (LFA), (i.e., a simple tongue swab, 3 user steps, no liquid transfers, and results within ~30 minutes). 3STEP also addresses challenges of spectral multiplexing in LAMP reactions by enabling spatial multiplexing for integrated detection of drug-resistant infections. Importantly, our novel stabilized interface technology (SIFT) used to create 3STEP enables both an ultra-cheap disposable and an affordable isothermal instrument design. In this SBIR Fast Track Phase I/Phase II proposal we will continue developing 3STEP for the detection of TB and rifampin resistant (RR) TB from tongue swabs by: In Aim 1 (Phase I), optimizing 3STEP for TB oral swabs using contrived samples, including designing and implementing RR testing into the spatial multiplexing capabilities of 3STEP; In Aim 2 (Phase I), prototyping and testing a POC lysis module; In Aim 3 (Phase I), assessing clinical sensitivity in a small pilot study using bio-banked samples collected through FIND’s FEND-TB program; In Aim 4 (Phase II), finalizing the 3STEP assay and consumable for an expanded clinical evaluation; And in Aim 5 (Phase II), performing a larger scale clinical evaluation of the multiplexed 3STEP TB/RR assay. Results will be important to subsequent funding efforts for 3STEP commercial development (assay and reader) and to demonstrate field-readiness for participation in TB diagnostic evaluation studies similar to R2D2, DriveDx4TB, SMART4TB, and FEND-TB.", "keywords": [ "Address", "Benchmarking", "Binding", "Biological Assay", "Budgets", "COVID-19", "Cause of Death", "Cessation of life", "Chemistry", "Clinic", "Clinical", "Clinical Sensitivity", "Closure by clamp", "Collection", "Communities", "Consultations", "Cytolysis", "DNA", "Detection", "Development", "Devices", "Diagnostic Procedure", "Diagnostic tests", "Disease", "Drug resistance", "Dryness", "Ensure", "Evaluation", "Evaluation Studies", "Freeze Drying", "Funding", "Future", "Health Care Facility", "Infection", "Injections", "Learning", "Liquid substance", "Manufacturer", "Methods", "Molds", "Molecular", "Mutation", "Mycobacterium tuberculosis", "Oral", "Oral Tuberculosis", "Organism", "Patients", "Performance", "Pharmacy facility", "Phase", "Pilot Projects", "Point of Care Technology", "Polymorphism Analysis", "Preparation", "Reaction", "Reader", "Readiness", "Recommendation", "Rifampicin resistance", "Sampling", "Single Nucleotide Polymorphism", "Small Business Innovation Research Grant", "Specificity", "Speed", "Sputum", "Stomach", "Swab", "Technology", "Testing", "Time", "Tongue", "Tube", "Tuberculosis", "Ultrasonics", "Urine", "Validation", "aspirate", "assay development", "biobank", "commercialization", "cost", "design", "drug testing", "feasibility testing", "instrument", "instrumentation", "lateral flow assay", "lymph node biopsy", "novel", "point of care", "point-of-care diagnostics", "programs", "prototype", "research clinical testing", "resistant strain", "resistant tuberculosis", "school based health center", "seal", "stability testing", "tuberculosis diagnostics", "urgent care" ], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1423, "count": 14222 } } }