Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=-start_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-start_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-start_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=-start_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=-start_date" }, "data": [ { "type": "Grant", "id": "6564", "attributes": { "award_id": "5P20GM103395-21", "title": "Alaska INBRE 4 One Health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 21992, "first_name": "Sheila", "last_name": "Caldwell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-24", "end_date": "2024-07-31", "award_amount": 4507434, "principal_investigator": { "id": 21993, "first_name": "BRIAN M", "last_name": "BARNES", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 751, "ror": "https://ror.org/01j7nq853", "name": "University of Alaska Fairbanks", "address": "", "city": "", "state": "AK", "zip": "", "country": "United States", "approved": true }, "abstract": "Alaska INBRE 4 - OVERALL PROJECT SUMMARY Since 2014, AK INBRE 3 has enhanced the research capacity of developing faculty and investigators throughout its network of University of Alaska universities by awarding pilot research grants, providing salaries to technicians, training of post-doctoral scientists and graduate and undergraduate students, and supporting travel, science advising, and equipment purchases. AK INBRE 3 provided support for bioinformatics and biostatistical analyses to network investigators through building local capacity in genomics, distributing service awards for DNA sequencing, data analysis, and networking with national bioinformatics centers, and supporting three summer workshops for advancing lab and computational skills. This support has been instrumental in increasing the number of independent NIH R-series awards to investigators in the network from 7 to 17 and total annual NIH funding to Alaska from $9.5 to $21.2M. Four developing faculty transitioned to independent status. To enhance translational and clinical research and strengthen its focus on Alaska Native health research as part of its research theme of One Health, AK INBRE 3 expanded its network in 2017 to include two Tribal health organizations, the Southcentral Foundation and the Alaska Native Tribal Health Consortium. AK INBRE 3 led statewide summits for the coordination of relevant curriculum development and provided support for new and augmented biomedical courses throughout the UA system. AK INBRE 3 supported research experiences for 100 undergraduate students in biomedical laboratories and proposes for AK INBRE 4 a new partnership with the Alaska Native Science and Engineering Program to increase the number of Alaska Native students pursuing careers in biomedical and behavioral health research. AK INBRE 3 developed an effective administrative core with capable leadership distributed across its network and transparent, merit-based mechanisms for distribution of support. It has helpful and committed advisory committees with national representation. AK INBRE 3 led efforts for the coordination of planning and sharing of resources with other infrastructure and diversity programs in Alaska with common goals of enhancing the health of people and communities and promoting workforce development in Alaska and the nation. In a time of economic stress, the University of Alaska has recruited 29 faculty with programs in biomedical and behavioral research and is committing substantial institutional support for investing in their development and the retention of successful investigators achieving independent researcher status through a Sustaining Research Excellence Core proposed for AK INBRE 4. An award for continuing the INBRE program will be crucial to building on the initial success of the new partnerships and sustaining the momentum of growth recently seen in biomedical and behavioral research in Alaska.", "keywords": [ "Address", "Advisory Committees", "Alaska", "Alaska Native", "Alaskan", "Animals", "Award", "Bacteriology", "Behavioral Research", "Bioinformatics", "Biomedical Research", "Biometry", "Clinical Research", "Collaborations", "Communities", "DNA sequencing", "Data Analyses", "Development", "Ecology", "Economics", "Educational workshop", "Engineering", "Environment", "Environmental Health", "Equipment", "Evaluation", "Faculty", "Family", "Fostering", "Foundations", "Funding", "Genomics", "Goals", "Growth", "Health", "Human", "Individual", "Infrastructure", "Institution", "Interdisciplinary Study", "Laboratories", "Leadership", "Minority Groups", "Modeling", "Modernization", "Native-Born", "Personal Satisfaction", "Postdoctoral Fellow", "Program Research Project Grants", "Reporting", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Support", "Resource Sharing", "Resources", "Science", "Scientist", "Series", "Services", "Stress", "Students", "System", "Time", "Training", "Training and Education", "Translational Research", "Travel", "United States National Institutes of Health", "Universities", "Wages", "Workforce Development", "base", "behavioral health", "bioinformatics network", "bioinformatics resource", "career", "curriculum development", "data acquisition", "data resource", "equipment acquisition", "experience", "graduate student", "health disparity", "health organization", "improved", "interdisciplinary collaboration", "knowledge base", "microbiome research", "outreach", "post-doctoral training", "programs", "recruit", "skills", "success", "symposium", "tribal health", "undergraduate student", "underserved minority" ], "approved": true } }, { "type": "Grant", "id": "6586", "attributes": { "award_id": "5P20GM103443-20", "title": "South Dakota Biomedical Research Infrastructure Network", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22074, "first_name": "Yang", "last_name": "Zhou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-24", "end_date": "2025-08-31", "award_amount": 3772381, "principal_investigator": { "id": 22075, "first_name": "Victor Chester", "last_name": "Huber", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1063, "ror": "https://ror.org/0043h8f16", "name": "University of South Dakota", "address": "", "city": "", "state": "SD", "zip": "", "country": "United States", "approved": true }, "abstract": "South Dakota Biomedical Research Infrastructure Network (SD BRIN), hosted by the Sanford School of Medicine of the University of South Dakota (USD) in Vermillion, SD, is the SD component of IDeA Networks of Biomedical Research Excellence (INBRE) funded by the NIH/NIGMS Institutional Development Award (IDeA) program since 2002. This proposal has evolved from insights gained and enhancements made during the previous phase of INBRE (2015-2020) especially related to the successful implementation of the Developmental Research Project Program for advancing the research initiatives of participating faculty members from our partners at predominantly undergraduate institutions. The specific aims of the SD BRIN program have not changed from its beginning. SD BRIN Aim 1 addresses the needs of biomedical researchers at USD (the lead research intensive institution) and provides resources and support to other researchers throughout the state. SD BRIN Aim 2 addresses the needs of science faculty and undergraduate researchers at the partner predominantly undergraduate institutions and tribal colleges. Therefore, the aims of this phase of INBRE in South Dakota are to: 1) Continue to develop the research capacity of South Dakota in the area of cell biology and the control of cell growth with special emphasis on proteomics and genomics by: a) enhancing the research capacity of investigators in proteomics, b) maintaining proteomics, bioinformatics, and nucleic acid sequencing and genotyping core facilities (with professional staff) accessible to investigators throughout SD (and other IDeA states), c) offering opportunities for graduate training in proteomics, nucleic acid sequencing, and bioinformatics, and d) supporting access to online library scientific databases to all faculty and students from all SD BRIN participating institutions. 2) Develop human resources for undergraduate and graduate programs in the biomedical sciences and bioinformatics by helping to instill a culture of research and provide a pipeline for students interested in biomedical research at South Dakota’s predominantly undergraduate institutions and tribal colleges by: a) providing research support and mentoring for faculty from participating institutions, b) providing opportunities for, and understanding of, cutting-edge scientific research for students at participating institutions, c) introducing undergraduates to graduate programs and future careers in biomedical sciences and bioinformatics, and d) enhancing science education and research capabilities at tribal colleges, providing opportunities for further education and careers in science and research.", "keywords": [ "Address", "Area", "Award", "Bioinformatics", "Biomedical Research", "Cells", "Cellular biology", "Core Facility", "Databases", "Development", "Education", "Faculty", "Funding", "Funding Agency", "Future", "Genetic", "Genomics", "Genotype", "Growth", "Human Resources", "Institution", "Lead", "Libraries", "National Institute of General Medical Sciences", "Network Infrastructure", "Nucleic acid sequencing", "Phase", "Program Research Project Grants", "Proteomics", "Publications", "Research", "Research Personnel", "Research Support", "Resources", "Science", "South Dakota", "Students", "Training", "United States National Institutes of Health", "Universities", "career", "cell growth", "education research", "faculty mentor", "insight", "interest", "medical schools", "member", "microbial", "programs", "science education", "tribal college", "undergraduate research", "undergraduate student" ], "approved": true } }, { "type": "Grant", "id": "6292", "attributes": { "award_id": "3P01AG019783-18S1", "title": "Causes and Consequences of Healthcare Efficiency", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21255, "first_name": "PARTHA", "last_name": "BHATTACHARYYA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-15", "end_date": "2023-02-28", "award_amount": 337564, "principal_investigator": { "id": 21256, "first_name": "AMBER E", "last_name": "BARNATO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 386, "ror": "https://ror.org/049s0rh22", "name": "Dartmouth College", "address": "", "city": "", "state": "NH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 21257, "first_name": "Carrie Hoverman", "last_name": "Colla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 386, "ror": "https://ror.org/049s0rh22", "name": "Dartmouth College", "address": "", "city": "", "state": "NH", "zip": "", "country": "United States", "approved": true }, "abstract": "CAUSES AND CONSEQUENCES OF HEALTHCARE EFFICIENCY: OVERVIEW U.S. health care spending is at an all-time high, yet life expectancy is stagnant, raising concerns that projected spending growth won’t lead to commensurate health gains. This is a problem especially pertinent to older adults, with a high burden of illness and intense use of health care. In this P01 renewal application, we propose to continue our long-standing work identifying efficiency and inefficiency in U.S. health care by applying sophisticated empirical methods to more than 1 billion person-years of health data. We address 3 topics integral to health care delivery efficiency: First, our exploration of challenges in clinical decision making is expected to identify systematic underuse of effective care and overuse of ineffective care, and provide evidence where clinical trials are lacking. Second, we will examine the role of the health care delivery environment – how do patient-sharing networks, payment models, and regulations affect patient health? Third, through our multi-payer data, we seek to understand the limitations of policy analysis arising from a focus on just Medicare or private (commercial) data. For example, we seek to measure how high commercial payment rates affect access for Medicare or Medicaid enrollees. All projects aim to measure and improve quality of care for older, vulnerable populations, including people with Alzheimer’s Disease and related dementia (ADRD). We propose 3 cores and 5 projects. Core A provides administrative support, Core B coordinates data;; and Core C (Methods) develops new approaches to network analysis used in all 5 projects. In Project 1, “Correlates and Consequences of Making an Alzheimer’s Disease Clinical Diagnosis,” we use the 100% Medicare files and clinically rich survey data to document variation in ADRD diagnosis, and test whether early diagnosis is, on net, beneficial to patients. Project 2, “The Causes and Consequences of Risky Prescribing,” uses Medicare Part D prescription data to study adverse outcomes associated with individual drugs and drug combinations including opioid analgesics, benzodiazepines, and sedative hypnotics. We consider forces influencing high-risk prescribing, such as shared-patient networks and legal restrictions. Project 3, “Identifying Efficient Health Care Providers: Evidence from Hospital Closures and Registry Data” uses peripheral vascular disease (PAD) registry data, and claims data, to estimate the relative expertise of community hospitals. This project will validate methods with natural experiments (hospital closing) and an ongoing randomized trial. Project 4, “Causes and Consequences of Variation in Public and Private Payment Rates,” hypothesizes that high commercial reimbursement rates can negatively affect access to care for Medicare and Medicaid patients. Finally, Project 5, “Physician Cognition, Inpatient Advance-Care Planning, and Outcomes for Seriously Ill Older Adults,” uses a combination of observational and experimental (randomized-trial) research in 250 community hospitals across the U.S. to improve the quality of inpatient physician decision-making.", "keywords": [ "Address", "Advance Care Planning", "Affect", "Age", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease related dementia", "Benefits and Risks", "Benzodiazepines", "Caring", "Characteristics", "Clinical", "Clinical Trials", "Cognition", "Community Hospitals", "Computing Methodologies", "Coupled", "Data", "Data Analyses", "Data Sources", "Decision Making", "Diagnosis", "Diagnostic", "Drug Combinations", "Drug Prescriptions", "Early Diagnosis", "Elderly", "Environment", "Environmental Risk Factor", "Evaluation", "Fee-for-Service Plans", "Growth", "Health", "Health Personnel", "Health Policy", "Health Services Accessibility", "Health and Retirement Study", "Healthcare", "Heterogeneity", "Hospital Closures", "Hospitals", "Income", "Individual", "Inpatients", "Insurance", "Intervention", "Laws", "Lead", "Legal", "Life Expectancy", "Measures", "Medicaid", "Medicare", "Medicare/Medicaid", "Methods", "Modeling", "Natural experiment", "Nurses", "Older Population", "Opioid Analgesics", "Outcome", "Pathway Analysis", "Patient Care", "Patient Preferences", "Patient-Focused Outcomes", "Patients", "Pattern", "Performance", "Peripheral Vascular Diseases", "Persons", "Physicians", "Play", "Policies", "Policy Analysis", "Price", "Privatization", "Quality of Care", "Regulation", "Research", "Research Proposals", "Risk", "Role", "Single-Payer System", "Source", "Surgeon", "Surveys", "System", "Testing", "Time", "Variant", "Vascular Diseases", "Vulnerable Populations", "Work", "acute care", "adverse outcome", "age group", "base", "burden of illness", "care delivery", "clinical Diagnosis", "clinical decision-making", "clinical practice", "cost", "data registry", "disease registry", "health care delivery", "health care service organization", "health care service utilization", "health data", "high risk", "hypnotic", "improved", "innovation", "mouse model", "negative affect", "novel strategies", "organizational structure", "outcome forecast", "payment", "randomized trial", "sedative" ], "approved": true } }, { "type": "Grant", "id": "7217", "attributes": { "award_id": "3R01DC005575-19S1", "title": "Genetic underpinnings of dysosmia in COVID-19", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Deafness and Other Communication Disorders (NIDCD)" ], "program_reference_codes": [], "program_officials": [ { "id": 23008, "first_name": "Bracie", "last_name": "Watson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-15", "end_date": "2022-08-31", "award_amount": 191875, "principal_investigator": { "id": 23009, "first_name": "XUE Z", "last_name": "LIU", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 872, "ror": "", "name": "UNIVERSITY OF MIAMI SCHOOL OF MEDICINE", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 872, "ror": "", "name": "UNIVERSITY OF MIAMI SCHOOL OF MEDICINE", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "entitled “Genetic underpinnings of dysosmia in COVID-19”: There is evidence that smell and taste dysfunction is an early and often the only identifier in COVI-19 positive patients. We hypothesize that genetic variants in specific candidate genes associated with the development of unique sensory phenotypes of COVID-19 patients: In patients reported to the American Academy of Otolaryngology-Head and Neck Surgery using the COVID-19 Anosmia Reporting Tool for Clinicians, in the first 237 entries anosmia was noted in 73% of patients prior to COVID-19 diagnosis and was the initial symptom in 26.6%. The occurrence in asymptomatic individuals makes this finding a useful target for public health screening and would facilitate earlier diagnosis and treatment, as well as the identification of those individuals who are not ill but still capable of spreading the disease. The mechanism underlying sensory alteration is currently unknown. Infectious diseases may demonstrate a heritable component – that is the propensity to contract and develop active infection and the severity of the immune response is influenced by host genetic factors to some extent and may reflect inter-individual variation in the host immune response. The genetic basis of this variability in response will provide important clues for therapeutics and lead to identification of groups at high risk of death. Public health measures to identify those at increased genetic risk of severe infection would be useful as a way of mitigating the economic effects of lockdown and social distancing policies. The genetic influence on COVID-19 symptoms may reflect genotype status of candidate genes such as ACE2 and TMPRSS2. Our team has been on the forefront to collect preliminary data on the presence of neurosensory disturbances in COVID-19 patients. We and others reported that anosmia is an important predictive symptom of COVID-19. Moreover, a UK twin study has shown that anosmia in COVID-19 patients has a high heritability (h2 = 0.48), suggesting that an individual's genotype plays a role in the presence or absence of this symptom. The goal of this study is to determine the susceptibility which may be influenced by host genotype to sensory disorders in COVID-19 patients to estimate the heritability of covid-19 sensory symptoms. In this study we will expand our work on following Specific Aim: Identify genetic variation associated with the development of dysosmia in COVID-19 patients. We hypothesize that there are genetic variants in the candidate genes that underlie smell and taste dysfunction in both symptomatic and otherwise asymptomatic COVID-19 patients. Preliminary data: We have established an international interdisciplinary collaboration team and have collected and published preliminary data on the role of ENT in COVID-19 and on the prevalence of sensory dysfunction in COVID-19 in our pilot studies. To determine if variants in specific candidate genes are associated with the development of anosmia in COVID-19 patients, we will collect DNA samples in our local COVID-19 patients and international patients from our collaborators for the study. In our hospitals, we have access to over 462 patients with confirmed positive COVID-19, 1565 with confirmed negative, and 390 patients with pending testing results. Over 10% of these patients report smell and taste dysfunction; our international collaborators have a large cohort of COVID-19 patients with smell and taste dysfunction available to us as well (see their LOS). We will perform WES on 120 samples from COVID-19 patients including 60 with smell and taste dysfunction and 60 without. We have established a COVID19 blood sample treatment process at our pathology lab for our ongoing study. Whole exome sequencing will be performed using established methods in the Center for Genome Technology in the Hussman Institute for Human Genomics (HIHG). Innovations in our proposal include: 1. Identify genetic markers for the early detection of mild and asymptotic COVID-19. 2. Our minority focused Miami sensory screening and genomic screening pipeline, and a database of genomic variation and phenotypes – sensory disorders and COVID-19-positive people. 3. A multidisciplinary, international collaboration with samples for duplicating studies.", "keywords": [ "2019-nCoV", "Academy", "Adult", "American", "Anosmia", "Biological Assay", "Blood specimen", "COVID-19", "COVID-19 pandemic", "Candidate Disease Gene", "Cells", "Child", "China", "Collaborations", "Communicable Diseases", "Contracts", "Cornea", "DNA", "Data", "Databases", "Development", "Diagnosis", "Disease", "Dysosmia", "Early Diagnosis", "Early identification", "Early treatment", "Economics", "Epithelial Cells", "France", "Functional disorder", "Genes", "Genetic", "Genetic Markers", "Genetic Risk", "Genetic Variation", "Genome", "Genomics", "Genotype", "Germany", "Goals", "Group Identifications", "Head and Neck Surgery", "Health Personnel", "Heritability", "Hospitals", "Immune response", "Individual", "Infection", "Institutes", "International", "Intestines", "Investigation", "Lead", "Measures", "Medical", "Methods", "Minority", "Multicenter Studies", "Nasal Epithelium", "Natural Immunity", "Olfactory Epithelial Cell", "Otolaryngology", "Pathology", "Patients", "Phenotype", "Pilot Projects", "Play", "Policies", "Predisposition", "Prevalence", "Process", "Provider", "Public Health", "Publishing", "Reporting", "Research", "Role", "Sampling", "Sensory", "Sensory Disorders", "Severities", "Smell Perception", "Social Distance", "Symptoms", "TMPRSS2 gene", "Taste Disorders", "Taste Perception", "Technology", "Test Result", "Therapeutic", "Twin Studies", "Variant", "Virus", "Work", "cohort", "early detection biomarkers", "exome sequencing", "genetic variant", "genomic variation", "high risk", "human genomics", "innovation", "inter-individual variation", "interdisciplinary collaboration", "mortality risk", "multidisciplinary", "neurosensory", "novel", "olfactory disorder", "respiratory", "response", "screening", "seroconversion", "sustentacular cell", "therapeutic target", "tool" ], "approved": true } }, { "type": "Grant", "id": "6563", "attributes": { "award_id": "3P20GM103440-19S1", "title": "Nevada IDeA Networks of Biomedical Research Excellence (INBRE)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 21990, "first_name": "LAKSHMI KUMAR", "last_name": "Matukumalli", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-09-01", "end_date": "2026-03-31", "award_amount": 720000, "principal_investigator": { "id": 21991, "first_name": "Jonathan E.", "last_name": "Baker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 953, "ror": "https://ror.org/01keh0577", "name": "University of Nevada Reno", "address": "", "city": "", "state": "NV", "zip": "", "country": "United States", "approved": true }, "abstract": "Overall Network Organization and Management Plan – Abstract In this proposal the NV INBRE will continue to pursue the goals of enhancing biomedical research infrastructure, research competitiveness, training and workforce development throughout the state of Nevada. The specific focus of this research is Cell Growth and Differentiation. Every two- and four-year teaching college and university in Nevada participates in this program as either Lead (University of Nevada, Reno), Partner (University of Nevada, Las Vegas and Desert Research Institute) or Outreach Institution. The Developmental Research Project Program (DRPP) will provide biomedical research opportunities designed to develop research scientists and provide students research experiences at both Partner and Outreach Institutions. Structured mentorship and collaboration programs enhance DRPP success. The Administrative Core will provide operational support and will coordinate undergraduate research programs at Outreach and Partner Institutions. Research faculty and students will present their research at the NV INBRE Annual Meeting as well as at scientific meetings held at two different Outreach Institutions. The Data Science Core will provide statewide research resources in bioinformatics, proteomics, genomics, cloud computing, and data storage and processing and will provide workshops, education, and training to Outreach and Partner Institutions. Nevada is a majority minority state and NV INBRE ensures that underrepresented populations are proportionally represented in our Administrative Core and in all of our programs. Through these programs, NV INBRE will continue to improve Nevada’s healthcare and biomedical workforce, infrastructure, and base.", "keywords": [ "Award", "Bioinformatics", "Biomedical Research", "COVID-19", "Centers of Research Excellence", "Cloud Computing", "Collaborations", "Communication", "Communities", "Complement", "Data Science Core", "Data Storage and Retrieval", "Development", "Differentiation and Growth", "Doctor of Philosophy", "Education", "Educational process of instructing", "Educational workshop", "Ensure", "Equipment", "Faculty", "Funding", "Goals", "Grant", "Growth", "Health", "Healthcare", "Human", "Infrastructure", "Institution", "Interdisciplinary Study", "Lead", "Leadership", "Mentorship", "Minority", "Mission", "Nevada", "Privatization", "Program Research Project Grants", "Proteomics", "Research", "Research Infrastructure", "Research Institute", "Research Personnel", "Research Project Grants", "Research Support", "Resources", "Scientist", "Services", "Site Visit", "Structure", "Students", "Time", "Training", "Training and Education", "Training and Infrastructure", "Underrepresented Populations", "Underrepresented Students", "United States National Institutes of Health", "Universities", "Work", "Workforce Development", "Writing", "base", "career", "cell growth", "college", "computerized data processing", "design", "experience", "faculty research", "genomics cloud", "improved", "interest", "medical schools", "meetings", "outreach", "outreach program", "programs", "response", "success", "undergraduate research", "undergraduate research experience", "undergraduate student", "web site" ], "approved": true } }, { "type": "Grant", "id": "6940", "attributes": { "award_id": "5P30AI050410-25", "title": "NC Collaborative HIV Epidemiology and Prevention (NC-CHEP) SWG", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2001-08-20", "end_date": "2026-05-31", "award_amount": 55310, "principal_investigator": { "id": 22788, "first_name": "Christopher Browning", "last_name": "Hurt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "– NC-CHEP SWG Despite a robust toolkit of prevention and treatment options, HIV incidence in the US stubbornly remains around 39,000 cases per year. The reasons for this sustained, endemic spread of HIV are complex and interconnected, making it an inherently challenging area of scholarship whose success depends on team science, interdisciplinary approaches. It is precisely this kind of dynamic research environment that CFAR Scientific Working Groups (SWGs) are designed for, and the UNC CFAR will promote research supporting Ending the HIV Epidemic efforts through its North Carolina (NC) Collaborative HIV Epidemiology and Prevention (CHEP) SWG. This team builds upon the long-standing partnership between UNC CFAR consortium partners and the NC Department of Health and Human Services (DHHS), applying epidemiological data at the intersection of biomedical and social sciences. The NC-CHEP SWG will bring together experts across disciplines and investigators new to HIV to share ideas and approaches, with the goal of fostering an academic environment conducive to thinking “outside the box.” Under a conceptual framework acknowledging the interconnected social, ecological, and clinical realities of HIV prevention and care, the NC-CHEP SWG aims to: (1) develop and refine resources for characterizing and exploring the HIV prevention and care continuum; (2) sponsor and support activities to bring together intra- and extramural expertise on basic, social, implementation, and prevention science to share perspectives and develop research ideas; and (3) identify, recruit, and mentor new and early career HIV investigators, highlighting the unique intersections among social science, basic science, and medicine within the HIV field. To achieve these aims, the NC-CHEP SWG will: (1) update and curate a SWG membership directory and place it online; (2) meet with NC DHHS personnel to understand available data, any interval changes, and how to continue successfully working with NC DHHS data scientists and epidemiologists for data sharing; (3) work with the Clinical Core to expand the number of HIV-uninfected, at-risk individuals represented in the UNC CFAR HIV Clinical Cohort database; (4) initiate and direct work to characterize the prevention and care continuum in the context of the COVID-19 pandemic; (5) offer consistent, regularly scheduled programming with physical and virtual options to help members stay abreast of the “state of the science” in treatment and biomedical HIV prevention; (6) promote high-quality research ideas based on team science approaches through face-to-face and digital (asynchronous) peer review; (7) work with key faculty at UNC and our partners at historically Black colleges and universities to promote HIV science as a career path; and (8) increase the reach of the SWG members for disseminating their research by partnering with the state’s AIDS Education and Training Center to host webinars, work-in-progress talks, and virtual symposia.", "keywords": [ "AIDS education", "AIDS prevention", "Acquired Immunodeficiency Syndrome", "Area", "Awareness", "Basic Science", "Behavioral", "Biology", "COVID-19 pandemic", "Career Choice", "Caring", "Clinical", "Clinical Sciences", "Collaborations", "Complex", "Concept Review", "Continuity of Patient Care", "Data", "Data Scientist", "Databases", "Development", "Diagnosis", "Directories", "Discipline", "Environment", "Epidemic", "Epidemiologist", "Epidemiology", "Extramural Activities", "Faculty", "Fostering", "Funding", "Funding Opportunities", "Goals", "HIV", "HIV Seropositivity", "HIV risk", "Healthcare", "Historically Black Colleges and Universities", "Human Resources", "Incidence", "Individual", "Investments", "Manuscripts", "Marriage", "Medicine", "Mentors", "Mentorship", "North Carolina", "Peer Review", "Perception", "Persons", "Pharmaceutical Preparations", "Play", "Prevention", "Provider", "Public Health", "Publications", "Research", "Research Personnel", "Research Support", "Resources", "Risk", "Role", "Safety", "Schedule", "Scholarship", "Science", "Scientific Advances and Accomplishments", "Site", "Social Sciences", "South Carolina", "Strategic Planning", "Technology", "Testing", "Training and Education", "Translating", "United States", "United States Dept. of Health and Human Services", "United States National Institutes of Health", "Universities", "Update", "Viral Load result", "Virus", "Work", "acute infection", "antiretroviral therapy", "base", "career", "cohort", "comparative", "cost", "data sharing", "design", "digital", "epidemiologic data", "health literacy", "implementation science", "improved", "interdisciplinary approach", "member", "new technology", "pre-exposure prophylaxis", "preventive intervention", "recruit", "scale up", "service delivery", "social", "social stigma", "success", "symposium", "tool", "transmission process", "virtual", "webinar", "working group" ], "approved": true } }, { "type": "Grant", "id": "7127", "attributes": { "award_id": "5U41HG002371-21", "title": "The UCSC Genome Browser", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22846, "first_name": "Christopher", "last_name": "Wellington", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-07-12", "end_date": "2022-06-30", "award_amount": 3552762, "principal_investigator": { "id": 22925, "first_name": "William James", "last_name": "Kent", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1547, "ror": "", "name": "UNIVERSITY OF CALIFORNIA SANTA CRUZ", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1547, "ror": "", "name": "UNIVERSITY OF CALIFORNIA SANTA CRUZ", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "This proposal describes plans to maintain and extend the UCSC Genome Browser at https://genome.ucsc.edu/ and its related web pages, databases, and computer programs. The web-based Genome Browser tool has been used by hundreds of thousands of biomedical researchers who seek to understand the human genome and those of other animals, particularly vertebrates and model organisms. The browser aggregates the research results of hundreds of biomedical labs – including a wide range of biochemical assays, genetic studies, curational efforts, sequencing projects, computer analyses, and text-mining of scientific literature – into a series of tracks aligned to the underlying DNA sequence. The genome provides a natural integration framework for these diverse data sources, which the browser exploits to its fullest at a variety of display scales ranging from the single base to individual genes, entire chromosomes, and ultimately to the genome as a whole. The Genome Browser is implemented using robust, fast, high-quality software capable of handling over one million hits per day. This web software provides a window into an exceptionally detailed and well-documented database that can be queried computationally as well as browsed graphically. The database is loaded with a suite of programs, developed both at UCSC and elsewhere, capable of distilling huge genomics data sets into high-quality annotations of the genome. Significant engineering effort is invested to ensure the quality of the software and data sets, including those developed by external contributors. We aim to extend the software and database in significant ways. We plan to develop displays for personal, family, and tumor genomes that will help researchers separate significant mutations from the background of other genetic variation. We will make it possible to view regions together in a single window that are separate in the linear structure of the chromosome, but in close proximity in the higher-order three-dimensional structure, or that are related by biochemical pathways, homology, or other relationships. We plan to develop a version of the browser optimized for mobile devices such as smartphones and tablets. We will improve the search capabilities we offer, particularly of large remote datasets. We will continue to import genome assemblies for species of biomedical interest, and integrate a broad range of useful new genomic data from the scientific community, including the ENCODE project. We will collaborate in developing and deploying data exchange standards such as file formats, APIs, and controlled vocabularies that help other groups leverage our resource and extend the reach of the browser to any dataset in compliance with the APIs. We will support this work with effective scientific, project, and personnel management; a plan for broadly disseminating the software tools, libraries, source code and data; and well-established training and outreach mechanisms.", "keywords": [ "Animal Model", "Animals", "Biochemical", "Biochemical Pathway", "Biological Assay", "Cellular Phone", "Chromosome Structures", "Chromosomes", "Communities", "Computer Analysis", "Computer software", "Controlled Vocabulary", "DNA", "DNA Sequence", "Data", "Data Analyses", "Data Set", "Data Sources", "Databases", "Education and Outreach", "Engineering", "Ensure", "Family", "Genes", "Genetic Variation", "Genetic study", "Genome", "Genomic Segment", "Genomics", "Human Genome", "Human Genome Project", "Individual", "Internet", "Libraries", "Literature", "Mutation", "Online Systems", "Other Genetics", "Personnel Management", "Research", "Research Personnel", "Resources", "Scientist", "Series", "Software Tools", "Source Code", "Tablets", "Variant", "Vertebrates", "Work", "base", "biomedical scientist", "cancer genome", "computer program", "data exchange", "diverse data", "file format", "genome annotation", "genome browser", "genome sequencing", "genomic data", "handheld mobile device", "improved", "interest", "programs", "text searching", "three dimensional structure", "tool", "web page", "web site", "web-based tool" ], "approved": true } }, { "type": "Grant", "id": "5918", "attributes": { "award_id": "3R01AA013328-14S1", "title": "Impact of supportive policies on minority stress, drinking and health among women", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20220, "first_name": "Robert", "last_name": "Freeman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-07-01", "end_date": "2022-07-31", "award_amount": 135171, "principal_investigator": { "id": 20221, "first_name": "TONDA L", "last_name": "HUGHES", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 20222, "first_name": "Alicia K", "last_name": "Matthews", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 163, "ror": "https://ror.org/02mpq6x41", "name": "University of Illinois at Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract. The proposed research responds directly to NOT-OD-20-097 by building on the aims of our current R01 study (AA013328-13). Over the past several decades research has clearly demonstrated that compared with their heterosexual counterparts, sexual minority women (SMW; lesbian, bisexual) are at substantially higher risk of hazardous drinking (HD; i.e., heavy average drinking, heavy episodic drinking, intoxication, adverse drinking consequences and alcohol dependence symptoms). HD-related risks among women are associated with stress. Added to the stress experienced by women in the general population are stressors unique to having a minority sexual identity, such as stigma and discrimination. Sexual minority stressors are likely amplified by COVID-19 (C-19). For the past 20 years, the Chicago Health and Life Experiences of Women (CHLEW) study has focused on identifying risk and protective factors and the mechanisms by which these factors influence HD among SMW. The parent grant for this supplement (CHLEW Waves 4 & 5; R01 AA013328) focuses on the impact of an historic structural-level event (i.e., legalization of same-sex marriage) assumed to be supportive of SMW and their health. We are now confronted by another historic macro-level event—the C-19 pandemic. In this case the impact is assumed to be threatening rather than supportive. To rapidly improve understanding of critical social and behavioral aspects of the pandemic relative to HD among SMW, we will add an online C-19 module to W5 of the CHLEW, currently underway. We will compare drinking outcomes in W5 with those assessed in W4 (2018-19), before the pandemic. The online C-19-specific questions will complement the unique and rich data on social and behavioral factors already collected that are highly relevant to the pandemic. Specific aims are to: Aim 1: Examine the impact of the C-19 pandemic on drinking outcomes in a diverse sample of SMW. To gain an understanding of C-19’s impact on drinking among SMW we will compare changes in drinking outcomes in W4 (2018-19) and in W5 (currently in progress). We expect that SMW overall will report higher volumes of alcohol consumption and higher levels of HD indicators following the onset of C-19. Aim 2: Compare drinking outcomes among SMW based on two major C-19- related impacts (isolation and loss of employment) and by race/ethnicity, age, and sexual identity. In general, we expect that SMW who are more isolated (e.g., live alone) and those who experience recent loss of employment will report greater increases in alcohol consumption and in HD than SMW who live with a partner or their families, or SMW who are employed. However, associations between these factors and drinking will vary by living situation (e.g., living with/caring for children or elderly parents) and type of employment (front-line or other high-risk job). We also expect to find subgroup differences in HD based on race/ethnicity, age, and sexual identity. Results of the study will enhance understanding of the pandemic’s personal and economic costs and behavioral outcomes in an already vulnerable population.", "keywords": [ "2019-nCoV", "Administrative Supplement", "Age", "Alcohol consumption", "Alcohol dependence", "Anxiety", "Attenuated", "Behavioral", "Bisexual", "COVID-19", "Chicago", "Child Care", "Complement", "Containment", "Coping Behavior", "Data", "Discrimination", "Elderly", "Employment", "Ethnic Origin", "Event", "Family", "Feeling suicidal", "General Population", "Health", "Health behavior", "Healthcare", "Heterosexuals", "Hispanics", "Intoxication", "Knowledge", "Latinx", "Legal", "Lesbian", "Life Experience", "Marriage", "Mental Depression", "Minority", "Occupations", "Outcome", "Parents", "Perception", "Personal Satisfaction", "Policies", "Positioning Attribute", "Race", "Reporting", "Research", "Risk", "Risk Factors", "Sampling", "Socioeconomic Status", "Stress", "Structure", "Subgroup", "Symptoms", "Vulnerable Populations", "Woman", "alcohol expectancy", "base", "behavioral outcome", "behavioral/social science", "binge drinking", "cohort", "coping", "cost outcomes", "drinking", "drinking behavior", "economic cost", "experience", "hazardous drinking", "health economics", "high risk", "improved", "pandemic disease", "parent grant", "protective factors", "psychologic", "public health relevance", "resilience", "response", "same-sex marriage", "sexual identity", "sexual minority", "social", "social stigma", "stressor", "substance use treatment", "theories" ], "approved": true } }, { "type": "Grant", "id": "6331", "attributes": { "award_id": "3P40OD011062-20S1", "title": "Rat Resource and Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 21352, "first_name": "Oleg", "last_name": "Mirochnitchenko", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-06-01", "end_date": "2021-02-28", "award_amount": 203950, "principal_investigator": { "id": 21353, "first_name": "Elizabeth C", "last_name": "Bryda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1049, "ror": "", "name": "UNIVERSITY OF MISSOURI-COLUMBIA", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1049, "ror": "", "name": "UNIVERSITY OF MISSOURI-COLUMBIA", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall goal of this proposal is to expand the functions and capabilities of the Rat Resource and Research Center (RRRC) to provide biomedical investigators with the rat models, embryonic stem cells, related reagents, protocols and services that will facilitate their research. The RRRC provides a unique repository service to the research community by importing, storing and distributing a large number of rat strains. It assures that valuable models are preserved and made available to interested investigators, allows researchers to satisfy NIH requirements for resource sharing, relieves individual investigators from the burden of animal distribution and ensures that models are maintained with rigorous genetic quality control and health monitoring to promote experimental reproducibility. Recent advances in genome editing technologies that can be used successfully in virtually any species to make targeted mutations (e.g., knock-outs and knock-ins) will facilitate the ability to genetically engineer rats to create new disease models. As a result, the number of rat models and the number of investigators using rat models for biomedical research is likely to increase substantially and the RRRC, as one of the only centralized repositories in the world will continue to serve a critical role for archiving and distributing these new models. To improve repository functions, applied research to optimize methods of sperm cryopreservation and subsequent recovery will be performed. To begin to address emerging awareness of the impact of the microbiome on model phenotype and experimental reproducibility, the RRRC will provide services to assess microbiota as well as conduct research to better characterize the gut microbiota in rats. To expand the broad utility of the RRRC, we propose to increase our fee-for-services in the areas of model generation, characterization, cryopreservation and rederivation. By expanding our services, the RRRC will serve as a much- needed “one stop” resource for investigators using rats in biomedical research.", "keywords": [ "Address", "Animal Model", "Animals", "Applied Research", "Archives", "Area", "Artificial Insemination", "Awareness", "Behavioral", "Biomedical Research", "CRISPR/Cas technology", "Cardiovascular system", "Communication", "Communities", "Congresses", "Consultations", "Cryopreservation", "Cytogenetics", "Derivation procedure", "Disease", "Disease model", "ES Cell Line", "Embryo", "Ensure", "Fee-for-Service Plans", "Fertilization in Vitro", "Generations", "Genetic", "Genetic Engineering", "Goals", "Health", "Individual", "Knock-out", "Libraries", "Methods", "Modeling", "Monitor", "Mus", "Mutation", "Phenotype", "Physiology", "Play", "Process", "Protocols documentation", "Quality Control", "Rat Strains", "Rattus", "Reagent", "Recovery", "Reproducibility", "Reproductive Biology", "Research", "Research Personnel", "Resource Sharing", "Resources", "Rodent Model", "Role", "Services", "Spectral Karyotyping", "Technology", "Therapeutic", "Time", "Tissues", "Toxicology", "United States", "United States National Institutes of Health", "Vendor", "assay development", "biomedical resource", "cost effective", "drug development", "embryonic stem cell", "genetic analysis", "genome editing", "gut microbiota", "human disease", "human model", "improved", "improved functioning", "innovation", "interest", "microbiome", "microbiota", "model development", "preservation", "rat genome", "repository", "service delivery", "sperm cell", "sperm cryopreservation", "stem", "virtual" ], "approved": true } }, { "type": "Grant", "id": "5209", "attributes": { "award_id": "3R01AI048638-22S1", "title": "Metabolic imprinting of dendritic cell fate and function in tissues", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 18435, "first_name": "Wendy F.", "last_name": "Davidson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2001-03-01", "end_date": "2025-01-31", "award_amount": 118275, "principal_investigator": { "id": 18436, "first_name": "BALI", "last_name": "PULENDRAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Dendritic cells (DCs) play a central role in sensing pathogens and tuning immune responses. Functionally distinct subsets of DCs can stimulate different types of immune responses, but DCs also display functional plasticity in response to microbial stimuli or signals from the tissue microenvironment. However, it is now clear that DCs sense not just microbial stimuli, but also various stress signals (e.g. amino acid starvation), through ancient stress sensing mechanisms, leading to a metabolic reprogramming of their function. In particular our recent work has revealed fundamental roles for two major amino acid sensors GCN2 and mTOR, in programming DCs to modulate adaptive immunity and inflammation. We have shown that GCN2 plays a role in programming DCs to respond to viral vaccination, and in controlling intestinal inflammation by promoting autophagy and suppressing inflammasome activation in gut APCs and epithelial cells. Furthermore, our recent data demonstrates that GCN2 regulates allergic inflammation in the lung. In addition to these effects of GCN2, we have recently shown that mTOR regulates developmental fate of DCs and alveolar macrophages (AMs) in the lung, and reprograms their metabolic state to modulate the outcome of allergic inflammation. In the following aims, we will determine the mechanisms of this metabolic imprinting. Aim 1: To determine the mechanisms by which mTOR controls the homeostasis and function of lung DCs and AMs in the steady state and during allergic inflammation. Our recent work demonstrates that in mice in which mTOR is genetically ablated in CD11c+ cells (mTORAPC mice): (i) CD103+ DCs and AMs in the lung are greatly reduced in number, in the steady state. (ii) Although the lung CD11c+CD11b+ DCs were numerically unaffected, they were skewed in their transcriptional identity towards the macrophage/monocytic profile. (iii) Lung allergic Th2 inflammation was skewed toward the Th17/neutrophilic phenotype. In the present aim, we will investigate the mechanisms underlying these effects, and investigate the potential role of 4E-BP3 dependent translational control, lipid metabolism and epigenetic reprograming in mediating the effects of mTOR signaling. Aim 2: To determine the mechanisms by which GCN2 regulates Th2 responses and allergic inflammation. Our preliminary data demonstrate that GCN2 knockout mice display markedly reduced allergic inflammation in the lung. In this aim we will determine the molecular mechanisms underlying this effect. The successful completion of these aims will yield rich mechanistic insights about metabolic imprinting of DC fate and function.", "keywords": [ "ATAC-seq", "Adoptive Transfer", "Allergic", "Allergic inflammation", "Alveolar Macrophages", "Amino Acids", "Autophagocytosis", "Bone Marrow", "Cell physiology", "Cells", "Cellular biology", "Chimera organism", "Data", "Dendritic Cells", "Development", "EIF4EBP1 gene", "Epigenetic Process", "Epithelial Cells", "FRAP1 gene", "Genetic Transcription", "Genetic Translation", "Hematopoietic", "Homeostasis", "ITGAM gene", "ITGAX gene", "Immune response", "Immunity", "In Situ", "Infection", "Inflammasome", "Inflammation", "Knockout Mice", "Lung", "Lymphoid Cell", "Mediating", "Metabolic", "Modeling", "Molecular", "Mus", "Natural Killer Cells", "Nature", "Organ", "Outcome", "Pathway interactions", "Phenotype", "Play", "Raptors", "Role", "Signal Pathway", "Signal Transduction", "Spleen", "Starvation", "Stimulus", "Stress", "Tissues", "Vaccination", "Viral", "Work", "adaptive immunity", "cell type", "conditional knockout", "functional plasticity", "gene repression", "imprint", "inflammatory disease of the intestine", "insight", "lipid metabolism", "mTOR Signaling Pathway", "macrophage", "metabolic profile", "microbial", "monocyte", "neutrophil", "pathogen", "programs", "pulmonary function", "receptor", "response", "sensor", "transcription factor" ], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1424, "count": 14236 } } }