Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=-abstract
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-abstract", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=-abstract", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=-abstract", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=-abstract" }, "data": [ { "type": "Grant", "id": "6453", "attributes": { "award_id": "3R01NR017649-04S1", "title": "A Randomized Controlled Trial to Reduce Hopelessness through Enhanced Physical Activity in Adults with Ischemic Heart Disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 21671, "first_name": "AMANDA ALISE", "last_name": "Price", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-08-01", "end_date": "2023-05-31", "award_amount": 159900, "principal_investigator": { "id": 21672, "first_name": "SUSAN L", "last_name": "DUNN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 163, "ror": "https://ror.org/02mpq6x41", "name": "University of Illinois at Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "(R01-funded parent RCT) Hopelessness is associated with a 3.4 times increased risk of mortality or nonfatal myocardial infarction in patients with ischemic heart disease (IHD), independent of depression. Hopelessness has been identified in 27–52% of patients with IHD and can persist for up to 12 months after hospital discharge. Hopelessness, a negative outlook and sense of helplessness toward the future, can be a temporary response to an event (state) or a habitual outlook (trait). Hopelessness is associated with decreased physical functioning and lower physical activity (PA) levels in individuals with IHD. Low levels of PA independently contribute to increased death and adverse events in patients with IHD. Rates of PA in IHD patients continue to be unacceptably low in both hospital-based cardiac rehabilitation and home settings. Hopelessness frequently compounds this issue. The links among hopelessness, PA, and mortality and morbidity for patients with IHD remain unknown. While research has investigated strategies to increase PA among IHD patients in general, we are the only group to design an intervention to promote PA specifically in hopeless IHD patients. Our work, based on Self Determination Theory and Cohen’s Stress and Coping Social Support Theory, has shown feasibility and preliminary efficacy for a motivational intervention that integrates social support from both the patient’s nurse and significant other to promote increased PA. The purpose of this randomized controlled trial is to establish the effectiveness of our 6-week mHealth intervention (Heart Up!) to promote increased PA in hopeless patients with IHD. We will enroll 225 hopeless IHD patients from a large community teaching hospital in the Midwest. Patients will be randomized (75 per group) to one of three groups: 1) motivational social support (MSS) from a nurse, 2) MSS from a nurse with additional significant other support (SOS), or 3) attention control (AC). Data will be collected at baseline, 8 and 24 weeks using an accelerometer for PA and valid and reliable instruments of physical and emotional health and behaviors. The specific aims are to: 1) test the effectiveness of 6 weeks of MSS and MSS with SOS on increasing mean minutes per day of moderate to vigorous PA, measured by an ActiGraph accelerometer; 2) determine the effects of change in minutes per day of moderate to vigorous PA on state hopelessness, measured by the State-Trait Hopelessness Scale; and 3): determine if social support (measured by the ENRICHD Social Support Inventory) and motivation (measured by the Exercise Self- Regulation Questionnaire) mediate the effects of the Heart Up! intervention on PA. The findings from this study could transform care for IHD patients who are hopeless by promoting self-management of important PA goals that can contribute to better health outcomes. This proposal supports NINR’s investment in self-management to improve the quality of life for individuals with chronic illness.", "keywords": [ "Accelerometer", "Adult", "Adverse event", "Anxiety", "Behavioral", "COVID-19", "COVID-19 pandemic", "Cardiac rehabilitation", "Caring", "Cessation of life", "Characteristics", "Chronic Disease", "Climacteric", "Communities", "Containment", "Coronavirus", "Data", "Data Collection", "Diagnosis", "Effectiveness", "Emotional", "Employment", "Enrollment", "Equipment and supply inventories", "Event", "Exercise", "Extended Family", "Feeling hopeless", "Feeling suicidal", "Food", "Funding", "Future", "Goals", "Health", "Health Professional", "Health behavior", "Healthcare", "Heart", "Heart Diseases", "Home environment", "Hospitals", "Income", "Individual", "Informal Social Control", "Institutional Review Boards", "Intervention", "Investments", "Knowledge", "Lead", "Life", "Link", "Measures", "Mediating", "Medical", "Mental Depression", "Mental Health", "Midwestern United States", "Morbidity - disease rate", "Motivation", "Multi-Ethnic Study of Atherosclerosis", "Myocardial Infarction", "Myocardial Ischemia", "Nurses", "Outcome", "Parents", "Participant", "Patient Care", "Patients", "Personal Satisfaction", "Persons", "Physical Function", "Physical activity", "Populations at Risk", "Positioning Attribute", "Protocols documentation", "Psyche structure", "Quality of life", "Questionnaires", "Randomized", "Randomized Controlled Trials", "Reporting", "Research", "Science", "Self Determination", "Self Management", "Shelter facility", "Social Distance", "Social support", "Stress", "Stress and Coping", "Symptoms", "Teaching Hospitals", "Telephone", "Testing", "Time", "United States National Institutes of Health", "Videoconferencing", "Vulnerable Populations", "Work", "actigraphy", "arm", "attentional control", "base", "behavioral health", "comparative", "effectiveness testing", "high risk", "high risk population", "improved", "innovation", "instrument", "longitudinal design", "mHealth", "moderate-to-vigorous physical activity", "mortality", "mortality risk", "motivational intervention", "pandemic disease", "programs", "public health emergency", "response", "social", "symposium", "theories", "therapy design", "three-arm study", "trait", "treatment arm" ], "approved": true } }, { "type": "Grant", "id": "5646", "attributes": { "award_id": "3R01NR017649-05S1", "title": "A Randomized Controlled Trial to Reduce Hopelessness through Enhanced Physical Activity in Adults with Ischemic Heart Disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 19530, "first_name": "AMANDA ALISE", "last_name": "Price", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-08-01", "end_date": "2023-05-31", "award_amount": 157147, "principal_investigator": { "id": 19531, "first_name": "SUSAN L", "last_name": "DUNN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 163, "ror": "https://ror.org/02mpq6x41", "name": "University of Illinois at Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "(R01-funded parent RCT) Hopelessness is associated with a 3.4 times increased risk of mortality or nonfatal myocardial infarction in patients with ischemic heart disease (IHD), independent of depression. Hopelessness has been identified in 27–52% of patients with IHD and can persist for up to 12 months after hospital discharge. Hopelessness, a negative outlook and sense of helplessness toward the future, can be a temporary response to an event (state) or a habitual outlook (trait). Hopelessness is associated with decreased physical functioning and lower physical activity (PA) levels in individuals with IHD. Low levels of PA independently contribute to increased death and adverse events in patients with IHD. Rates of PA in IHD patients continue to be unacceptably low in both hospital-based cardiac rehabilitation and home settings. Hopelessness frequently compounds this issue. The links among hopelessness, PA, and mortality and morbidity for patients with IHD remain unknown. While research has investigated strategies to increase PA among IHD patients in general, we are the only group to design an intervention to promote PA specifically in hopeless IHD patients. Our work, based on Self Determination Theory and Cohen’s Stress and Coping Social Support Theory, has shown feasibility and preliminary efficacy for a motivational intervention that integrates social support from both the patient’s nurse and significant other to promote increased PA. The purpose of this randomized controlled trial is to establish the effectiveness of our 6-week mHealth intervention (Heart Up!) to promote increased PA in hopeless patients with IHD. We will enroll 225 hopeless IHD patients from a large community teaching hospital in the Midwest. Patients will be randomized (75 per group) to one of three groups: 1) motivational social support (MSS) from a nurse, 2) MSS from a nurse with additional significant other support (SOS), or 3) attention control (AC). Data will be collected at baseline, 8 and 24 weeks using an accelerometer for PA and valid and reliable instruments of physical and emotional health and behaviors. The specific aims are to: 1) test the effectiveness of 6 weeks of MSS and MSS with SOS on increasing mean minutes per day of moderate to vigorous PA, measured by an ActiGraph accelerometer; 2) determine the effects of change in minutes per day of moderate to vigorous PA on state hopelessness, measured by the State-Trait Hopelessness Scale; and 3): determine if social support (measured by the ENRICHD Social Support Inventory) and motivation (measured by the Exercise Self- Regulation Questionnaire) mediate the effects of the Heart Up! intervention on PA. The findings from this study could transform care for IHD patients who are hopeless by promoting self-management of important PA goals that can contribute to better health outcomes. This proposal supports NINR’s investment in self-management to improve the quality of life for individuals with chronic illness.", "keywords": [ "Accelerometer", "Adherence", "Adult", "Adverse event", "Cardiac rehabilitation", "Cardiovascular system", "Caring", "Cellular Phone", "Cessation of life", "Chronic", "Chronic Disease", "Communities", "Control Groups", "Data", "Diagnosis", "Effectiveness", "Effectiveness of Interventions", "Elderly", "Emotional", "Energy Metabolism", "Enrollment", "Equipment and supply inventories", "Event", "Exercise", "Feeling hopeless", "Female", "Future", "General Population", "Goals", "Guidelines", "Health", "Health behavior", "Heart", "Heart Diseases", "Home", "Hospitals", "Hour", "Individual", "Informal Social Control", "Interdisciplinary Study", "Intervention", "Investments", "Link", "Measures", "Mediating", "Mental Depression", "Midwestern United States", "Mission", "Modeling", "Morbidity - disease rate", "Motivation", "Movement", "Muscle", "Myocardial Infarction", "Myocardial Ischemia", "Nurses", "Outcome", "Patient Care", "Patient-Focused Outcomes", "Patients", "Physical Function", "Physical activity", "Population", "Quality of life", "Questionnaires", "Randomized", "Randomized Controlled Trials", "Recommendation", "Reporting", "Research", "Research Personnel", "Risk", "Risk Factors", "Sampling", "Science", "Self Determination", "Self Management", "Social support", "Stress and Coping", "Support Groups", "Teaching Hospitals", "Testing", "Text Messaging", "Time", "Training", "Translations", "Woman", "Work", "actigraphy", "attentional control", "base", "design", "effectiveness testing", "exercise program", "high risk", "high risk population", "improved", "innovation", "instrument", "mHealth", "men", "moderate-to-vigorous physical activity", "mortality", "mortality risk", "motivational enhancement therapy", "motivational intervention", "novel", "physical inactivity", "programs", "response", "socioeconomic disadvantage", "theories", "therapy design", "trait" ], "approved": true } }, { "type": "Grant", "id": "7651", "attributes": { "award_id": "1R01MD016026-01", "title": "Reducing Racial Disparities in SMM post COVID19: Assessing the integration of maternal safety bundles and community based doulas to improve outcomes for Black women", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6437, "first_name": "Rada K", "last_name": "Dagher", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-17", "end_date": "2025-06-30", "award_amount": 717913, "principal_investigator": { "id": 23456, "first_name": "NDIDIAMAKA", "last_name": "AMUTAH-ONUKAGHA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 863, "ror": "", "name": "TUFTS UNIVERSITY BOSTON", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22627, "first_name": "Hafsatou", "last_name": "Diop", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1517, "ror": "", "name": "MASSACHUSETTS STATE DEPT OF PUB HEALTH", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, { "id": 23457, "first_name": "EUGENE R", "last_name": "DECLERCQ", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 863, "ror": "", "name": "TUFTS UNIVERSITY BOSTON", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "(Project Summary) Black women experience stark disparities in pregnancy care, complications, and outcomes, compared to White women. Recognizing, tracking and understanding patterns of severe maternal mortality (SMM) and associated inequities by race/ethnicity, along with developing and carrying out interventions to improve the quality of maternal care, are essential to reducing SMM and thereby maternal mortality. To date, there has been little research specifically aimed at understanding whether the maternal health inequities as experienced by Black women can be ameliorated through an integrated care model that includes engagement of mothers of color in the planning and implementation of maternal safety bundles in addition to prenatal, birth and postpartum support from community doulas. We intend to use the Health Impact Pyramid to develop, implement and assess the effectiveness of such a system in reducing disparities in SMM and mortality. The data sources for this study will include state-level and hospital-specific discharge data collected as part of the Alliance for Innovation on Maternal Health (AIM) project; the Maternal Mortality Review Committee (MMRC); and the Pregnancy to Early Life Longitudinal (PELL) data system, which focuses on population-level data needed to examine health inequities among racial and ethnic minorities in Massachusetts. In addition to these existing data sources, we intend to establish a data collection tool to assess doula services as well as analyze qualitative data from interviews with black women, and focus groups with providers and doulas to explore the effect of incorporating doula-provided services into prenatal, birth and postpartum care. This proposal has three main study areas that will lead to a systematic understanding of ways to address and prevent SMM among black women and thus, establish a foundation for the development, testing and scale-up of future interventions to improve maternal health outcomes: 1) Use longitudinally linked hospital discharge data from PELL (2008-2018) to characterize preconception, prenatal and postpartum hospital encounters among women with SMM in order to identify key points where opportunities to intervene were missed. 2): Among hospitals that serve black women, to assess the impact of implementing maternal safety bundles to ensure that black women are receiving quality obstetric care 3): Examine how systems integrating community-based doula support could decrease the inequities of SMM among black and white mothers. Our study will lead to a more systematic understanding of pregnancy outcomes for Black women at highest risk of SMM, thus establishing a foundation for development and testing of future interventions to improve maternal outcomes.", "keywords": [ "Address", "Area", "Attitude", "Biological", "Birth", "COVID-19", "Caring", "Centers for Disease Control and Prevention (U.S.)", "Color", "Communities", "Data", "Data Collection", "Data Linkages", "Data Sources", "Development", "Discipline of obstetrics", "Effectiveness", "Ensure", "Ethnic Origin", "Ethnic group", "Focus Groups", "Foundations", "Future", "Health", "Health Personnel", "Hemorrhage", "High Prevalence", "High Risk Woman", "Hispanics", "Hospitalization", "Hospitals", "Hybrids", "Hypertension", "Individual", "Information Systems", "Intervention", "Interview", "Investigation", "Life", "Link", "Live Birth", "Massachusetts", "Maternal Health", "Maternal Mortality", "Medical Care Team", "Methods", "Modeling", "Morbidity - disease rate", "Mothers", "Not Hispanic or Latino", "Outcome", "Pattern", "Perinatal Care", "Population", "Postpartum Period", "Pregnancy", "Pregnancy Complications", "Pregnancy Outcome", "Prenatal care", "Process", "Provider", "Public Health", "Race", "Recommendation", "Reporting", "Research", "Review Committee", "Risk", "Safety", "Services", "System", "Testing", "Time", "United States", "Woman", "Women&apos", "s Group", "Women&apos", "s Health", "base", "design", "disparity reduction", "ethnic minority population", "experience", "health care service utilization", "health disparity", "implementation science", "improved", "improved outcome", "innovation", "longitudinal design", "maternal outcome", "mortality", "mortality disparity", "obstetric care", "peer", "postpartum care", "prenatal", "prevent", "preventable death", "programs", "racial disparity", "racial minority", "scale up", "secondary analysis", "severe maternal morbidity", "tool" ], "approved": true } }, { "type": "Grant", "id": "8981", "attributes": { "award_id": "5R01MD016026-02", "title": "Reducing Racial Disparities in SMM post COVID19: Assessing the integration of maternal safety bundles and community based doulas to improve outcomes for Black women", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6437, "first_name": "Rada K", "last_name": "Dagher", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-17", "end_date": "2025-06-30", "award_amount": 630060, "principal_investigator": { "id": 23456, "first_name": "NDIDIAMAKA", "last_name": "AMUTAH-ONUKAGHA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 863, "ror": "", "name": "TUFTS UNIVERSITY BOSTON", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22627, "first_name": "Hafsatou", "last_name": "Diop", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1517, "ror": "", "name": "MASSACHUSETTS STATE DEPT OF PUB HEALTH", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, { "id": 23457, "first_name": "EUGENE R", "last_name": "DECLERCQ", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 863, "ror": "", "name": "TUFTS UNIVERSITY BOSTON", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "(Project Summary) Black women experience stark disparities in pregnancy care, complications, and outcomes, compared to White women. Recognizing, tracking and understanding patterns of severe maternal mortality (SMM) and associated inequities by race/ethnicity, along with developing and carrying out interventions to improve the quality of maternal care, are essential to reducing SMM and thereby maternal mortality. To date, there has been little research specifically aimed at understanding whether the maternal health inequities as experienced by Black women can be ameliorated through an integrated care model that includes engagement of mothers of color in the planning and implementation of maternal safety bundles in addition to prenatal, birth and postpartum support from community doulas. We intend to use the Health Impact Pyramid to develop, implement and assess the effectiveness of such a system in reducing disparities in SMM and mortality. The data sources for this study will include state-level and hospital-specific discharge data collected as part of the Alliance for Innovation on Maternal Health (AIM) project; the Maternal Mortality Review Committee (MMRC); and the Pregnancy to Early Life Longitudinal (PELL) data system, which focuses on population-level data needed to examine health inequities among racial and ethnic minorities in Massachusetts. In addition to these existing data sources, we intend to establish a data collection tool to assess doula services as well as analyze qualitative data from interviews with black women, and focus groups with providers and doulas to explore the effect of incorporating doula-provided services into prenatal, birth and postpartum care. This proposal has three main study areas that will lead to a systematic understanding of ways to address and prevent SMM among black women and thus, establish a foundation for the development, testing and scale-up of future interventions to improve maternal health outcomes: 1) Use longitudinally linked hospital discharge data from PELL (2008-2018) to characterize preconception, prenatal and postpartum hospital encounters among women with SMM in order to identify key points where opportunities to intervene were missed. 2): Among hospitals that serve black women, to assess the impact of implementing maternal safety bundles to ensure that black women are receiving quality obstetric care 3): Examine how systems integrating community-based doula support could decrease the inequities of SMM among black and white mothers. Our study will lead to a more systematic understanding of pregnancy outcomes for Black women at highest risk of SMM, thus establishing a foundation for development and testing of future interventions to improve maternal outcomes.", "keywords": [ "Address", "Area", "Attitude", "Biological", "Birth", "COVID-19", "Caring", "Centers for Disease Control and Prevention (U.S.)", "Color", "Communities", "Data", "Data Collection", "Data Linkages", "Data Sources", "Development", "Discipline of obstetrics", "Ensure", "Ethnic Origin", "Ethnic group", "Focus Groups", "Foundations", "Future", "Health", "Health Personnel", "Hemorrhage", "High Prevalence", "High Risk Woman", "Hispanics", "Hospitalization", "Hospitals", "Hypertension", "Individual", "Information Systems", "Intervention", "Interview", "Investigation", "Life", "Link", "Live Birth", "Massachusetts", "Maternal Health", "Maternal Mortality", "Medical Care Team", "Methods", "Modeling", "Morbidity - disease rate", "Mothers", "Not Hispanic or Latino", "Outcome", "Pattern", "Perinatal Care", "Population", "Postpartum Period", "Pregnancy", "Pregnancy Complications", "Pregnancy Outcome", "Prenatal care", "Provider", "Public Health", "Race", "Recommendation", "Reporting", "Research", "Review Committee", "Risk", "Services", "System", "Testing", "Time", "United States", "Woman", "Women&apos", "s Group", "Women&apos", "s Health", "base", "black women", "design", "disparity reduction", "effectiveness evaluation", "ethnic minority population", "experience", "health care service utilization", "health disparity", "health inequalities", "hybrid type 1 trial", "implementation framework", "implementation outcomes", "implementation process", "implementation science", "improved", "improved outcome", "innovation", "longitudinal design", "maternal outcome", "maternal safety", "mortality", "mortality disparity", "obstetric care", "peer", "postpartum care", "prenatal", "prevent", "preventable death", "programs", "racial disparity", "racial minority", "scale up", "secondary analysis", "severe maternal morbidity", "tool" ], "approved": true } }, { "type": "Grant", "id": "9677", "attributes": { "award_id": "1P30ES032756-01A1", "title": "Pilot Project Program", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-06-24", "end_date": "2026-03-31", "award_amount": 378860, "principal_investigator": { "id": 25498, "first_name": "Thomas", "last_name": "Hartung", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "(PILOT PROJECT PROGRAM) The Pilot Project Program (PPP) is critical to the ability of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease (CHARMED) to achieve its central goals of fostering innovative interdisciplinary research in environmental health, translating knowledge into action to address community environmental challenges in the Maryland region, and nurturing and supporting the next generation of environmental scientists. Funding pilot grants represents a major strategy for promoting and supporting community-scientist partnerships, seeding emerging research areas, driving development of novel scientific approaches, and supporting translational research in environmental health research that could evolve into independently funded research. The Specific Aims of the PPP are to: 1) To foster and support research that addresses environmental health challenges of communities in the Maryland region; 2) facilitate the dissemination of findings from CHARMED-supported Pilot Projects to relevant stakeholders; and 3) evaluate the effectiveness and impact of the PPP. To achieve these goals, the PPP will provide pilot project funding for four types of research proposals: 1) Community-Engaged Research (CEnR) Awards, which will be awarded to any JHU or university faculty in the Maryland region working together with community partners on projects designed and conducted with the active participation of said partners; 2) Career Development Awards (CD), which will promote and support the success of the careers of Early Stage and Mid-career Investigators in community- engaged environmental health research; 3) New Direction Awards (ND), which will support high impact, innovative projects that focus on the scientific themes of the Center, especially those which lead to the pursuit of multi-investigator grants; which will be awarded to established investigators from non-environmental health disciplines who intend to expand their research to include environmental health research; 4) Rapid Response Pilot Project Awards (RRP), which will enable investigators to address emergent environmental concerns (e.g. hurricanes, COVID-19, oil spills) and or to generate preliminary data for grant submissions or resubmissions to enhance their chances of success. Applications will receive high priority if they address important community concerns, are likely to lead to extramural funding, utilize one or more facility cores, and or bring innovative approaches to the field. As all pilot project grant awardees will be expected to become Center members and participate in all Center activities, we anticipate that this funding mechanism will greatly expand the community- engaged research activities of the Center by fostering an ecosystem of innovative research in environmental health focused on the main scientific themes of the Center.", "keywords": [ "Address", "Area", "Automobile Driving", "Award", "COVID-19", "Communities", "Community Health", "Core Facility", "Data", "Decision Making", "Development", "Discipline", "Disease", "Ecosystem", "Environmental Exposure", "Environmental Health", "Extramural Activities", "Faculty", "Faculty Recruitment", "Fostering", "Funding", "Funding Mechanisms", "Goals", "Grant", "Group Meetings", "Historically Black Colleges and Universities", "Hurricane", "Incentives", "Institution", "Interdisciplinary Study", "K-Series Research Career Programs", "Knowledge", "Lead", "Maryland", "Mentorship", "Neighborhood Health Center", "Oils", "Outcome", "Peer Review", "Pennsylvania", "Pilot Projects", "Press Releases", "Public Health", "Publications", "Research", "Research Activity", "Research Personnel", "Research Proposals", "Research Support", "Resources", "Risk", "Science", "Scientist", "Seeds", "Services", "Time", "Translating", "Translational Research", "Translations", "Universities", "base", "career", "community center", "community engaged research", "dashboard", "design", "effectiveness evaluation", "environmental justice", "faculty community", "high risk", "improved", "innovation", "meetings", "member", "mid-career faculty", "new technology", "next generation", "novel", "prevent", "programs", "response", "social media", "success", "symposium", "web site" ], "approved": true } }, { "type": "Grant", "id": "11234", "attributes": { "award_id": "5P30ES032756-02", "title": "Pilot Project Program", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-06-24", "end_date": "2026-03-31", "award_amount": 378860, "principal_investigator": { "id": 25498, "first_name": "Thomas", "last_name": "Hartung", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "(PILOT PROJECT PROGRAM) The Pilot Project Program (PPP) is critical to the ability of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease (CHARMED) to achieve its central goals of fostering innovative interdisciplinary research in environmental health, translating knowledge into action to address community environmental challenges in the Maryland region, and nurturing and supporting the next generation of environmental scientists. Funding pilot grants represents a major strategy for promoting and supporting community-scientist partnerships, seeding emerging research areas, driving development of novel scientific approaches, and supporting translational research in environmental health research that could evolve into independently funded research. The Specific Aims of the PPP are to: 1) To foster and support research that addresses environmental health challenges of communities in the Maryland region; 2) facilitate the dissemination of findings from CHARMED-supported Pilot Projects to relevant stakeholders; and 3) evaluate the effectiveness and impact of the PPP. To achieve these goals, the PPP will provide pilot project funding for four types of research proposals: 1) Community-Engaged Research (CEnR) Awards, which will be awarded to any JHU or university faculty in the Maryland region working together with community partners on projects designed and conducted with the active participation of said partners; 2) Career Development Awards (CD), which will promote and support the success of the careers of Early Stage and Mid-career Investigators in community- engaged environmental health research; 3) New Direction Awards (ND), which will support high impact, innovative projects that focus on the scientific themes of the Center, especially those which lead to the pursuit of multi-investigator grants; which will be awarded to established investigators from non-environmental health disciplines who intend to expand their research to include environmental health research; 4) Rapid Response Pilot Project Awards (RRP), which will enable investigators to address emergent environmental concerns (e.g. hurricanes, COVID-19, oil spills) and or to generate preliminary data for grant submissions or resubmissions to enhance their chances of success. Applications will receive high priority if they address important community concerns, are likely to lead to extramural funding, utilize one or more facility cores, and or bring innovative approaches to the field. As all pilot project grant awardees will be expected to become Center members and participate in all Center activities, we anticipate that this funding mechanism will greatly expand the community- engaged research activities of the Center by fostering an ecosystem of innovative research in environmental health focused on the main scientific themes of the Center.", "keywords": [ "Address", "Area", "Automobile Driving", "Award", "COVID-19", "Communication", "Communities", "Core Facility", "Data", "Decision Making", "Development", "Discipline", "Disease", "Ecosystem", "Environmental Exposure", "Environmental Health", "Extramural Activities", "Faculty", "Faculty Recruitment", "Fostering", "Funding", "Funding Mechanisms", "Goals", "Grant", "Group Meetings", "Health", "Historically Black Colleges and Universities", "Hurricane", "Incentives", "Interdisciplinary Study", "K-Series Research Career Programs", "Knowledge", "Lead", "Maryland", "Mentorship", "Neighborhood Health Center", "Oils", "Outcome", "Peer Review", "Pennsylvania", "Pilot Projects", "Press Releases", "Public Health", "Publications", "Research", "Research Activity", "Research Institute", "Research Personnel", "Research Proposals", "Research Support", "Resources", "Risk Reduction", "Science", "Scientist", "Services", "Time", "Translating", "Translational Research", "Translations", "Universities", "career", "community center", "community engaged research", "dashboard", "design", "effectiveness evaluation", "environmental justice", "high risk", "improved", "innovation", "meetings", "member", "mid-career faculty", "new technology", "next generation", "novel", "prevent", "programs", "response", "social media", "success", "symposium", "web site" ], "approved": true } }, { "type": "Grant", "id": "12206", "attributes": { "award_id": "1UC7AI180309-01", "title": "UofL RBL Operations, Workforce Development and Pandemic Preparedness Research", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 27982, "first_name": "FAYNA C", "last_name": "Diaz San Segundo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-18", "end_date": "2028-07-31", "award_amount": 2935664, "principal_investigator": { "id": 28078, "first_name": "KENNETH E", "last_name": "PALMER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 795, "ror": "https://ror.org/01ckdn478", "name": "University of Louisville", "address": "", "city": "", "state": "KY", "zip": "", "country": "United States", "approved": true }, "abstract": "(OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is operated by the University Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The RBL is a regional resource that facilitates translational research to develop diagnostics, prognostics, therapeutics and vaccines to mitigate biodefense and emerging infectious disease threats. Our Center operates the only BSL-3 and ABSL-3 facilities currently operating in the Commonwealth of Kentucky. The CPM mandate is to prepare for and respond to public health emergencies, such as the COVID-19 pandemic. The broad, long-range objectives and goals of the University of Louisville (UofL) CPM RBL are: 1. To offer state-of-the-art research services to the regional and national biomedical research community to learn from past pandemics and biological warfare experiences and effectively predict and mitigate future emerging infectious disease threats. 2. To manage, maintain and operate the UofL RBL to serve the national and regional need for biocontainment facilities suitable for research on Risk Group 3 pathogens and other biothreats. 3. To follow a philosophy of continuous improvement in BSL-3 and ABSL-3 work practices and to ensure that all personnel who need to access BSL-3 and ABSL-3 containment laboratories are appropriately trained and prepared to serve the national and regional need for biocontainment research professionals. To achieve these aims we propose to establish three collaborative Cores. The Facilities Management Maintenance and Operations Core (FMMO Core) is responsible for ensuring that the facility is always available to meet the research and emergency preparedness mission of the RBL. The BSL-3 Practices and Workforce Development Core (BSL-3PWD Core) formalizes our mentor-mentee training plan to ensure our laboratory is staffed with BSL-3 research professionals who are proficient at biocontainment research professionals. This core responds to the reality that response to rapidly emerging public health emergencies like COVID-19 is limited by the number of available BSL-3 trained and experienced research professionals. Our Pandemic Preparedness and Response Integrated Research Core (PaPR Core) responds to the substantially increased requests for our BSL-3 research services by organizing an integrated full-service BSL-3 research support function to support investigator needs. These cores will work in unison to achieve the CPM mission: to prepare for and respond to public health emergencies like the COVID-19 pandemic.", "keywords": [ "Attention", "Biological Warfare", "Biomedical Research", "Biotechnology", "COVID-19", "COVID-19 pandemic", "COVID-19 patient", "China", "Clinical Trials", "Communities", "Containment", "Creativeness", "Crowns", "Dedications", "Diagnostic", "Disease Outbreaks", "Economics", "Emerging Communicable Diseases", "Ensure", "Federal Government", "Funding Opportunities", "Future", "Goals", "Health Services Research", "Health care facility", "Hospitals", "Hour", "Human Resources", "Industry", "Infection", "Institution", "International", "Investigational New Drug Application", "Kentucky", "Laboratories", "Leadership", "Learning", "Maintenance", "Managed Care", "Medicine", "Mentors", "Mission", "Modeling", "National Center for Advancing Translational Sciences", "National Institute of Diabetes and Digestive and Kidney Diseases", "Nose", "Patients", "Philosophy", "Play", "Public Health", "Research", "Research Personnel", "Research Support", "Resources", "Rest", "Reverse Transcriptase Polymerase Chain Reaction", "Risk", "Role", "Scientist", "Serology test", "Services", "System", "Talents", "Techniques", "Testing", "Therapeutic", "Training", "Translational Research", "United States National Institutes of Health", "Universities", "University resources", "Vaccines", "Work", "Workforce Development", "biocontainment facility", "biodefense", "biothreat", "cohort", "experience", "improved", "laboratory experience", "medical countermeasure", "metropolitan", "novel", "novel coronavirus", "operation", "pandemic disease", "pandemic preparedness", "pandemic response", "pathogen", "previous pandemic", "prognostic", "prophylactic", "public health emergency", "recruit", "response", "service organization", "skills", "wastewater surveillance" ], "approved": true } }, { "type": "Grant", "id": "9766", "attributes": { "award_id": "1P50CA271338-01", "title": "Advancing cancer care and equity through telehealth, communication science, and behavioral economics", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 25610, "first_name": "ROBIN CLINE", "last_name": "Vanderpool", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-01", "end_date": "2027-07-31", "award_amount": 1137500, "principal_investigator": { "id": 25611, "first_name": "Justin", "last_name": "Bekelman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25612, "first_name": "Katharine", "last_name": "Rendle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 25613, "first_name": "ANIL", "last_name": "VACHANI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "(OVERALL) The University of Pennsylvania Telehealth Research Center in Cancer Care (Penn TRC) will apply insights from communication science and behavioral economics to design and test innovative telehealth strategies to improve effectiveness and equity across the cancer care continuum, with an emphasis on understanding mechanisms of action. The COVID-19 pandemic led to dramatic growth in the use of telehealth for cancer care delivery, fostered by both clinical need and temporary waivers. Telehealth strategies have included both synchronous communication (real-time video or telephone conferencing) and asynchronous communication (sequential health information exchange through text messaging or secure portals). Yet, fundamental knowledge gaps include the extent to which telehealth may be superior to non-telehealth care delivery strategies for access, quality, and outcomes; how telehealth may enhance or detract from achieving health equity in cancer care in the context of the digital divide and persistent cancer disparities; and the impact of telehealth on health care efficiency. The Penn TRC will address an overarching research theme: to apply insights from communication science and behavioral economics to design and test synchronous telehealth strategies, supported by asynchronous elements, to improve access, quality, outcomes, equity, and efficiency across the cancer care continuum. We focus on lung cancer as a model for telehealth across the care continuum, from screening to treatment to survivorship. We bring together a team of international experts in communication science, behavioral economics, cancer care delivery, telehealth, health care innovation, mixed methods, and health equity to achieve the following specific aims: 1) Apply concepts, strategies, tools, and methods from communication science and behavioral economics to design and test synchronous telehealth strategies, supported by asynchronous elements, to improve access, quality, outcomes, equity, and efficiency for patients across the care continuum; 2) Conduct a pragmatic randomized clinical trial to compare the effectiveness of telehealth strategies to increase shared decision making for lung cancer screening using a Sequential Multiple Assignment Randomized Trial (SMART) design; 3) Conduct two rapid-cycle pilot projects, with methods and measures aligned with the pragmatic trial, to design and test the effectiveness of telehealth to improve cancer care, identify multilevel mechanisms of action, and lay the foundation for future, more definitive pragmatic trials; and 4) Build capacity to advance a national telehealth research agenda and train the next generation of investigators with expertise in cancer care, telehealth and health equity. By joining together interdisciplinary faculty across Penn, the Penn TRC will result in novel, scalable, and generalizable disseminated strategies to drive lasting improvements in cancer care and health equity. Penn has an unparalleled environment in which to bring together these areas of study.", "keywords": [ "Address", "Advanced Malignant Neoplasm", "American", "Area", "Award", "COVID-19 pandemic", "Clinical", "Communication", "Communication Methods", "Continuity of Patient Care", "Discipline", "Doctor of Philosophy", "Effectiveness", "Elements", "Environment", "Faculty", "FarGo", "Fostering", "Foundations", "Future", "Goals", "Grant", "Growth", "Health", "Health Services Accessibility", "Healthcare", "Improve Access", "Individual", "International", "Intervention", "Knowledge", "Learning", "Malignant neoplasm of lung", "Measures", "Methods", "Mind", "Modeling", "Molecular", "Nurses", "Outcome", "Palliative Care", "Patients", "Pennsylvania", "Pilot Projects", "Randomized Clinical Trials", "Recommendation", "Research", "Research Methodology", "Research Personnel", "Resources", "Science", "Secure", "Sequential Multiple Assignment Randomized Trial", "Telephone", "Testing", "Text Messaging", "Time", "Training", "Universities", "Work", "asynchronous communication", "behavioral economics", "cancer care", "cancer health disparity", "care delivery", "clinical practice", "compare effectiveness", "design", "digital", "effectiveness testing", "evidence base", "health equity", "improved", "innovation", "insight", "lung cancer screening", "next generation", "novel", "pragmatic trial", "screening", "shared decision making", "survivorship", "symposium", "telehealth", "tool", "trial design", "waiver" ], "approved": true } }, { "type": "Grant", "id": "7374", "attributes": { "award_id": "3U42OD011140-18S1", "title": "National Swine Resource and Research Center 1", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 20741, "first_name": "MIGUEL A.", "last_name": "CONTRERAS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2003-09-01", "end_date": "2023-07-31", "award_amount": 499943, "principal_investigator": { "id": 23167, "first_name": "RANDALL S", "last_name": "PRATHER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1049, "ror": "", "name": "UNIVERSITY OF MISSOURI-COLUMBIA", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23168, "first_name": "Kevin Dale", "last_name": "Wells", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1049, "ror": "", "name": "UNIVERSITY OF MISSOURI-COLUMBIA", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "(Overall) The overall goal of this application is to continue and expand operation of the National Swine Resource and Research Center (NSRRC). The NSRRC is in its 14th year of operation and it has developed the infrastructure needed to assist swine-based research across multiple disciplines, including xenotransplantation. The NSRRC has developed new models of human disease by genetic engineering, it has recruited models created by others, and it has distributed expertise, cells, tissues, organs and pigs to investigators throughout the United States. Since genetic engineering of pigs requires specialized facilities and expertise, the NSRRC provides invaluable services to the research community by using the latest in gene editing technology to create new genetically-engineered swine models. The NSRRC also provides training and education by interacting with individuals, publishing manuscripts and sponsoring workshops and meetings that promote the use of pigs for studying human diseases. The NSRRC has a state-of-the-art building with high biosecurity to house animals free of specific pathogens. The Specific Aims for the upcoming grant period are as follows: 1. To operate the National Swine Research and Resource Center. Functions of the NSRRC will continue to include: a) importation of existing swine models of human health and disease; b) rederivation of pigs to eliminate specific pathogens, and health monitoring to assure maintenance of a specific pathogen-free status; c) cryopreservation and storage of gametes, embryos, and somatic cells to prevent future loss of valuable models; d) distribution of expertise, reagents, cells, tissues, organs, and pathogen-free pigs; and e) use state of the art technology for the creation of new genetically-engineered pigs needed by the biomedical research community. Rigorous quality control will ensure that only high quality genetics are distributed. The NSRRC will also serve as a site for training and educational activities related to research employing swine models. 2. To perform innovative research that will benefit the NSRRC and the biomedical research community. Applied research projects are aimed at improving: a) the cryopreservation of pig reproductive cells and tissues, b) methods for the production of genetically-engineered pigs, c) state-of-the-art testing methods for swine health surveillance, and d) right-size the pig for greater adoption of pig models.", "keywords": [ "Adoption", "Anatomy", "Animals", "Applied Research", "Area", "Arteriosclerosis", "Biomedical Research", "Cardiovascular Diseases", "Cells", "Characteristics", "Communicable Diseases", "Communities", "Country", "Critical Pathways", "Cryopreservation", "Diabetes Mellitus", "Discipline", "Disease", "Educational Activities", "Educational workshop", "Embryo", "Ensure", "Family suidae", "Future", "Genes", "Genetic", "Genetic Diseases", "Genetic Engineering", "Genetic Materials", "Germ Cells", "Goals", "Grant", "Health", "Human", "Individual", "Infrastructure", "Laboratories", "Maintenance", "Manuscripts", "Medical Device", "Medical Research", "Methods", "Modeling", "Modification", "Molecular", "Monitor", "Optics", "Organ", "Patients", "Pharmaceutical Preparations", "Physiological", "Physiology", "Play", "Production", "Progress Reports", "Publishing", "Quality Control", "Reagent", "Reproducibility", "Research", "Research Personnel", "Research Project Grants", "Resources", "Role", "Scientist", "Serologic tests", "Services", "Site", "Somatic Cell", "Study models", "Technology", "Testing", "Therapeutic", "Therapeutic Agents", "Tissues", "Training Activity", "Training and Education", "Translational Research", "United States", "United States National Institutes of Health", "Xenograft procedure", "animal care", "base", "biosecurity", "clinical practice", "drug development", "embryo cell", "experience", "germ free condition", "human disease", "human model", "improved", "innovation", "investigator training", "meetings", "novel therapeutic intervention", "novel therapeutics", "operation", "pathogen", "pig genome", "pre-clinical", "predictive modeling", "prevent", "recruit", "repository", "rho", "sperm cell", "tool" ], "approved": true } }, { "type": "Grant", "id": "7779", "attributes": { "award_id": "3R01EB022230-04S1", "title": "Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 22599, "first_name": "TATJANA", "last_name": "Atanasijevic", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-09-16", "end_date": "2022-09-21", "award_amount": 651080, "principal_investigator": { "id": 23584, "first_name": "Hak Soo SOO", "last_name": "Choi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23585, "first_name": "Maged M", "last_name": "Henary", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "(limit within 30 lines) The COVID-19 emerged in December 2019 and then spread rapidly over 214 countries. As of May 15, 2020, a total of more than 4.5M confirmed cases and over 300,000 deaths have been reported worldwide, posing significant health and economic threats to our society. Currently, an array of drugs approved for other indications have been studied, in addition to multiple investigational agents, for the treatment of COVID-19. Antivirals including remdesivir, favipiravir, chloroquine, and hydroxychloroquine have been rapidly tested in these clinical studies and demonstrated preliminary efficacy against COVID-19. However, these studies also revealed that a proportion of patients receiving remdesivir had significant adverse effects, including multiple-organ dysfunction syndrome, septic shock, and acute liver and kidney injury. Similarly, the use of chloroquine and hydroxychloroquine in COVID-19 patients has raised serious safety concerns including arrhythmias, cardiomyopathy, and retinopathy. These adverse effects are related to their wide distribution of drugs in the whole body after administration, causing damages in off-target vital organs. Therefore, tissue-specific delivery of antiviral therapeutics would ameliorate adverse effects while maintaining their efficacy to treat COVID-19. Our hypothesis that renal clearable ultrasmall nanocarriers can payload antiviral drugs selectively and deliver them to treat COVID-19 with reduced side effects. In our parent R01 (NIBIB #R01EB022230), we have developed ultrasmall nanocarriers for targeting, imaging, and image-guided surgery of pancreatic neuroendocrine tumors. Importantly, over 80% of the unbound dose was ultimately eliminated into the urine within 24 h post-injection after systemic circulation. This narrows the design of nanocarriers to include a targeting anchor, an imaging moiety, and a distribution domain, and we have worked diligently to create a reciprocal arrangement whereby each chemical composition provides balancing properties to the others. Interestingly, during the evaluation of inclusion complexation, we found that the nanocarriers can deliver other types of drugs including imatinib (Kang et al. Adv Mater, 2020). This result suggests that ultrasmall nanocarriers can also deliver antiviral drugs to the target with reduced side effects due to rapid renal clearance of unbound molecules. Therefore, the ultimate goal in this administrative supplement application is to develop ultrasmall nanotherapeutics that are complexed with antivirals to treat COVID-19. By payloading selected antiviral drugs into the ultrasmall nanocarriers, we will be able to achieve image-guided drug delivery to the respiratory system with reduced side effects due to the rapid renal clearance of unbound drugs. To achieve this goal, we propose 1) to develop renal clearable nanocarriers for antiviral drug delivery and 2) to evaluate the pharmacodynamics and therapeutic efficacy of the nanocarriers in mouse models of coronavirus infection. 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