Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1405&sort=-abstract
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-abstract", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-abstract", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1406&sort=-abstract", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1404&sort=-abstract" }, "data": [ { "type": "Grant", "id": "15987", "attributes": { "award_id": "1R21AI196149-01", "title": "Identification of Novel Targets for Enhancing Targeted RNA Degradation in Antiviral Discovery", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32536, "first_name": "DIPANWITA", "last_name": "BASU", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2026-02-05", "end_date": "2028-01-31", "award_amount": 451000, "principal_investigator": { "id": 44441, "first_name": "Jingxin", "last_name": "Wang", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 3437, "ror": "", "name": "UNIVERSITY OF CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT The development of targeted RNA degradation (TRD) technologies, such as RNA-degrading chimeras, holds significant promise for antiviral therapies by reducing viral RNA levels to prevent viral replication. Despite their potential, current TRD mechanisms exhibit limited potency. In various literature reports, ribonuclease- targeting chimeras (RIBOTACs) exemplify this problem, achieving only ~75% maximum degradation of distinct RNA targets in cells. For example, our preliminary work optimized a synthetic RNA ligand, C34, which binds robustly to an RNA G bulge in the 5’ untranslated region of SARS-CoV-2’s RNA genome with a low nanomolar dissociation constant. However, the minimum inhibitory concentration (MIC) of the C34-based RIBOTAC remained moderately high at 20 μM in SARS-CoV-2-infected cells, indicating insufficient cellular potency. RIBOTAC is a drug-induced TRD modality utilizing an endogenous ribonuclease, RNase L. Interestingly, this RIBOTAC potency cap in cells was not observed in cell-free assays using purified recombinant RNase L, indicating the possible presence of cellular factors that inhibit the RNase L degradation complex. To address this potency limitation, the proposed project aims to discover novel cellular targets to significantly enhance RNase L activity and brand-new TRD mechanisms for future drug development through two specific aims. Aim 1 focuses on identifying cellular determinants that inhibit RNase L-dependent RIBOTAC activity using a genome-wide CRISPR knockout screen. By targeting these inhibitory genes, we aim to significantly boost the efficacy of existing RIBOTACs. Aim 2 focuses on discovering novel cellular targets for TRD by performing genome-wide screenings in three screening platforms. We will utilize a plasmid library comprising ~14,000 open reading frames from the human genome to identify candidate genes that can effectively induce TRD through drug-induced proximity. Both aims will leverage a SARS-CoV-2 cellular model and our optimized RNA ligand C34 to validate these new mechanisms in antiviral research. Ultimately, this project seeks to expand our chemical genetics toolbox by unveiling new mechanisms and targets for RNA degradation. These advancements will be pivotal in developing new chimeric molecules designed to combat a variety of infectious diseases, significantly enhancing our capacity to address global health challenges. 1", "keywords": [ "2019-nCoV", "5' Untranslated Regions", "Address", "Anti-viral Therapy", "Autophagocytosis", "Bar Codes", "Binding", "Biochemical", "Biological Assay", "Candidate Disease Gene", "Cell model", "Cells", "Chimera organism", "Clinical", "Clustered Regularly Interspaced Short Palindromic Repeats", "Communicable Diseases", "Complex", "DNA", "Data", "Degradation Pathway", "Development", "Dissociation", "Exhibits", "Exposure to", "Flow Cytometry", "Future", "Gene Targeting", "Genes", "Genome", "Guide RNA", "Human", "Human Genome", "Individual", "Infection", "Infection Control", "Integration Host Factors", "Knock-out", "Libraries", "Life Cycle Stages", "Ligands", "Literature", "Luciferases", "Minimum Inhibitory Concentration measurement", "Minor Groove", "Modality", "Modeling", "Open Reading Frames", "Pancreatic ribonuclease", "Pathway interactions", "Pharmaceutical Preparations", "Plasmids", "Protac", "Proteins", "Protocols documentation", "RNA", "RNA Binding", "RNA Degradation", "Recombinants", "Reporting", "Research", "Ribonucleases", "Structure", "Tacrolimus Binding Proteins", "Technology", "Therapeutic", "Untranslated RNA", "Untranslated Regions", "Viral", "Virus", "Virus Replication", "Work", "antiviral drug development", "arm", "candidate identification", "candidate validation", "cellular targeting", "chemical genetics", "combat", "cytotoxicity", "design", "drug development", "drug discovery", "druggable target", "genome wide screen", "genome-wide", "global health", "human disease", "improved", "inhibitor", "interest", "nanomolar", "novel", "novel therapeutics", "pharmacologic", "prevent", "protein degradation", "recruit", "screening", "success", "transcriptome sequencing", "viral RNA", "virulence gene", "whole genome" ], "approved": true } }, { "type": "Grant", "id": "15278", "attributes": { "award_id": "1R21HD116227-01", "title": "Investigating the impact of COVID-19 pandemic child care closures on developmental outcomes of young children in low-income families", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8605, "first_name": "JAMES", "last_name": "GRIFFIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-08-07", "end_date": "2026-07-31", "award_amount": 263134, "principal_investigator": { "id": 31865, "first_name": "Maria Jose", "last_name": "Prados", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract The COVID-19 pandemic exacerbated many existing inequalities, including access to child care, education, and family support services. Children in low-income families and minorities, already vulnerable, were overrepresented in areas with high rates of pandemic- induced child care center closures. This is especially concerning in a context where children exposed to environmental risk factors like poverty and maltreatment face significant barriers in early identification of developmental disorders and early intervention. Child care centers can be instrumental for timely identification and reporting developmental delays, and early intervention is key to prevent further developmental disorders. Early education and quality child care have been found to help vulnerable children’s development in many dimensions. Therefore, the potential impact of the pandemic in general, and of childcare center closures in particular, on vulnerable children’s development is concerning. To date, little is known about the quantitative impact of these disruptions on vulnerable children’s outcomes. The purpose of the proposed analysis is to measure the effects of decreased access to child care centers during the pandemic on COVID-19 pandemic on developmental screening outcomes of infants and toddlers in low-income and at-risk families who receive services from a home visitation program. In a context of pre-existing inequities, this project also seeks to elucidate how structural inequalities disproportionately hurting low-income families and racial- ethnic minorities affect this impact. Inferring causality about these issues is typically challenging because a family’s characteristics that affect its childcare options and location decisions may also determine the child’s developmental outcomes. To tackle this issue, we will exploit the geographic variation in disruptions in child care centers closures during the pandemic as a natural experiment generating exogenous variation in availability. Correctly assessing any expected deteriorations in the developmental progress of vulnerable and at-risk children in these communities is crucial to determine early intervention actions that can address this issue. Results from this work will increase our understanding of the potential long-term consequences of the COVID-19 crisis via its effect on vulnerable children. Our findings will also speak to the broader issue of the consequences of structural inequalities and lack of family support for our children’s development, and can serve as guidelines for policies and health initiatives targeted at vulnerable children and their families.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6664", "attributes": { "award_id": "5R25GM142065-02", "title": "Project SCORE (Student Centered Outcomes Research Experience)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22329, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-06-01", "end_date": "2026-02-28", "award_amount": 262474, "principal_investigator": { "id": 22330, "first_name": "Marie", "last_name": "Barnard", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 311, "ror": "https://ror.org/02teq1165", "name": "University of Mississippi", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 311, "ror": "https://ror.org/02teq1165", "name": "University of Mississippi", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Project SCORE Systemic inequities in access to healthcare and quality educational opportunity for the youth of Mississippi (MS) are powerful forces that disengage students from entering pathways toward STEM careers. Project SCORE (Student Centered Outcomes Research Experience) proposes to engage students from groups underrepresented in STEM career trajectories through a youth participatory action research (YPAR) approach, capturing and retaining their attention through the immediacy of health threats such as COVID-19. Guided by a YPAR approach, Project SCORE will leverage a near-peer mentor model to engage and support underrepresented students in an exploration of the field of public health. Project SCORE will bring together underrepresented high school and graduate health sciences students from two communities with significant health disparities in a year-long weekly afterschool program to develop relevant health behavior research questions, provide training in research methods, and facilitate the development of student-conducted research projects mentored by near-peer graduate health sciences students and faculty. A student-centered research agenda will be developed to support future research initiatives. Students will complete their experience with a week-long on campus immersion experience. This project seeks to increase awareness of and interest in public health, science engagement, and STEM careers, as well as increase matriculation into higher education STEM programs to enhance and diversify the future biomedical workforce.", "keywords": [ "Address", "Adolescent", "Adopted", "Advocate", "Affect", "Area", "Attention", "Awareness", "Bachelor&apos", "s Degree", "Behavior", "Birth", "COVID-19", "Career Exploration", "Chronic Disease", "Communication", "Communities", "Development", "Education", "Educational Intervention", "Engineering", "Exercise", "Exposure to", "Faculty", "Future", "Health", "Health Food", "Health Promotion", "Health Sciences", "Health Status", "Health behavior", "Health education", "Healthy Eating", "High School Student", "Immersion", "Individual", "Intervention", "Knowledge", "Leadership", "Mediation", "Mentors", "Methods", "Mississippi", "Modeling", "Occupations", "Outcome", "Outcomes Research", "Participant", "Pathway interactions", "Patients", "Populations at Risk", "Prevention", "Public Health", "Public Health Education", "Published Comment", "Reporting", "Research", "Research Methodology", "Research Project Grants", "Research Subjects", "Role", "STEM career", "STEM program", "Science", "Scientist", "Seat Belts", "Students", "Time", "Tobacco use", "Training", "Underrepresented Populations", "Underrepresented Students", "United States", "Work", "Youth", "after-school program", "biobehavior", "career", "career awareness", "college", "community based participatory research", "community engaged research", "community engagement", "data literacy", "design", "experience", "graduate student", "health care availability", "health care quality", "health disparity", "health literacy", "high risk sexual behavior", "high school", "higher education", "improved", "insight", "interest", "intervention program", "matriculation", "next generation", "novel", "patient oriented", "peer", "peer coaching", "preventable death", "programs", "protective behavior", "public health intervention", "recruit", "skills", "social", "synergism" ], "approved": true } }, { "type": "Grant", "id": "8357", "attributes": { "award_id": "1R25GM142065-01", "title": "Project SCORE (Student Centered Outcomes Research Experience)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-06-01", "end_date": "2026-02-28", "award_amount": 267641, "principal_investigator": { "id": 22330, "first_name": "Marie", "last_name": "Barnard", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 311, "ror": "https://ror.org/02teq1165", "name": "University of Mississippi", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 311, "ror": "https://ror.org/02teq1165", "name": "University of Mississippi", "address": "", "city": "", "state": "MS", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Project SCORE Systemic inequities in access to healthcare and quality educational opportunity for the youth of Mississippi (MS) are powerful forces that disengage students from entering pathways toward STEM careers. Project SCORE (Student Centered Outcomes Research Experience) proposes to engage students from groups underrepresented in STEM career trajectories through a youth participatory action research (YPAR) approach, capturing and retaining their attention through the immediacy of health threats such as COVID-19. Guided by a YPAR approach, Project SCORE will leverage a near-peer mentor model to engage and support underrepresented students in an exploration of the field of public health. Project SCORE will bring together underrepresented high school and graduate health sciences students from two communities with significant health disparities in a year-long weekly afterschool program to develop relevant health behavior research questions, provide training in research methods, and facilitate the development of student-conducted research projects mentored by near-peer graduate health sciences students and faculty. A student-centered research agenda will be developed to support future research initiatives. Students will complete their experience with a week-long on campus immersion experience. This project seeks to increase awareness of and interest in public health, science engagement, and STEM careers, as well as increase matriculation into higher education STEM programs to enhance and diversify the future biomedical workforce.", "keywords": [ "Address", "Adolescent", "Adopted", "Advocate", "Affect", "Area", "Attention", "Awareness", "Bachelor&apos", "s Degree", "Behavior", "Birth", "COVID-19", "Career Exploration", "Chronic Disease", "Communication", "Communities", "Development", "Education", "Educational Intervention", "Engineering", "Exercise", "Exposure to", "Faculty", "Future", "Health", "Health Food", "Health Promotion", "Health Sciences", "Health Status", "Health behavior", "Health education", "Healthy Eating", "High School Student", "Immersion", "Individual", "Intervention", "Knowledge", "Leadership", "Mediation", "Mentors", "Methods", "Mississippi", "Modeling", "Occupations", "Outcome", "Outcomes Research", "Participant", "Pathway interactions", "Patients", "Populations at Risk", "Prevention", "Public Health", "Public Health Education", "Published Comment", "Reporting", "Research", "Research Methodology", "Research Project Grants", "Research Subjects", "Role", "STEM career", "STEM program", "Science", "Scientist", "Seat Belts", "Students", "Time", "Tobacco use", "Training", "Underrepresented Populations", "Underrepresented Students", "United States", "Work", "Youth", "after-school program", "biobehavior", "career", "career awareness", "college", "community based participatory research", "community engaged research", "community engagement", "data literacy", "design", "experience", "graduate student", "health care availability", "health care quality", "health disparity", "health literacy", "high risk sexual behavior", "high school", "higher education", "improved", "insight", "interest", "intervention program", "matriculation", "next generation", "novel", "patient oriented", "peer", "peer coaching", "preventable death", "programs", "protective behavior", "public health intervention", "recruit", "skills", "social", "synergism" ], "approved": true } }, { "type": "Grant", "id": "15706", "attributes": { "award_id": "1K23GM159013-01", "title": "Targeting Immune Dysregulated Endotypes in Sepsis (TIDES)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 24133, "first_name": "SYDELLA ANNE", "last_name": "BLATCH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2028-05-31", "award_amount": 179475, "principal_investigator": { "id": 32578, "first_name": "Robert B", "last_name": "Lindell", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1073, "ror": "", "name": "CHILDREN'S HOSP OF PHILADELPHIA", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Pediatric sepsis is the leading cause of death of hospitalized children worldwide. While sepsis is defined as life-threatening organ dysfunction that develops in the setting of immune dysregulation, optimal management of immune dysregulation in pediatric sepsis is a fundamental knowledge gap. A successful precision medicine approach to pediatric sepsis requires that we understand the molecular events that cause organ failure, which of these events are potentially reversible, and how to identify this reversible patient pathobiology in real-time. We recently identified features of cellular immune dysregulation in children with sepsis and used proteomics to define three molecular subphenotypes which predict the severity of organ failure and mortality. Reproducible, validated molecular sepsis subphenotypes are viable candidates for translation to clinical trials, as models based on clinical data and plasma proteins could be used to identify “treatable traits” in real-time for both prognostic and predictive enrichment. Our preliminary data also identifies a pathologic and potentially reversible role for STAT3 hyperactivation in our most severe sepsis subphenotype. The IL-6/JAK/STAT3 signaling pathway is a canonical inflammatory pathway associated with capillary leak, endothelial dysfunction, emergency granulopoiesis, and lymphocyte dysregulation. Selective and non-selective JAK inhibitors have been used clinically to treat COVID-19 ARDS and pediatric hemophagocytic lymphohistiocytosis (HLH). It is not known if JAK inhibition can reverse immune dysregulation in sepsis, despite its related pathobiology. We propose to address these current knowledge gaps by defining and validating molecular subphenotype that predicts sepsis severity and testing the reversibility of T cell STAT3 hyperactivation. The overall objectives of this application are to define and prospectively evaluate a model to identify prognostic molecular sepsis subphenotypes (Aim 1) and to determine the impact of ex vivo JAK/STAT inhibition to reduce immune dysregulation in pediatric patients with sepsis (Aim 2). My central hypothesis is that immune dysregulation in pediatric sepsis can be identified in the plasma proteome and reversed with targeted immunomodulation. By validating a model to prospectively identify prognostic molecular sepsis subphenotypes and determining the impact of JAK/STAT inhibition on immune dysregulation, this study will support a precision approach to immunomodulation in pediatric patients with sepsis. My long-term goal is to design precision approaches to immunomodulation in critically ill children as a translational critical care physician-scientist trained in computational human immunology. I am optimally situated to perform these studies given my background as a clinician, my experience in prospective cohort development and proteomic subphenotyping, and the strong mentorship and supportive environment at CHOP/UPenn. The K23 award will provide new skills in translational research and computational analysis, facilitating my development as an independent investigator with expertise in translational human immunology.", "keywords": [ "Address", "Blood capillaries", "Blood specimen", "COVID-19 patient", "COVID-19 treatment", "COVID-19/ARDS", "Cause of Death", "Childhood", "Clinical", "Clinical Data", "Clinical Trials", "Computer Analysis", "Computing Methodologies", "Critical Care", "Critically ill children", "Cryopreservation", "Data", "Data Set", "Development", "Dimerization", "Emergency Situation", "Enrollment", "Event", "Factor Analysis", "Flow Cytometry", "Functional disorder", "Genetic Transcription", "Goals", "Granulopoiesis", "Hemophagocytic Lymphohistiocytoses", "Hospitalized Child", "Human", "IL6ST gene", "Immune", "Immune Targeting", "Immunoassay", "Immunology", "Inflammatory", "Interleukin-6", "JAK1 gene", "Knowledge", "Life", "Lymphocyte", "Machine Learning", "Mediating", "Mentored Clinical Scientist Development Program", "Mentored Patient-Oriented Research Career Development Award", "Mentorship", "Modeling", "Molecular", "Multiomic Data", "Multiple Organ Failure", "Organ", "Organ failure", "Pathologic", "Pathway interactions", "Patients", "Performance", "Peripheral Blood Mononuclear Cell", "Phenotype", "Phosphorylation", "Physicians", "Plasma", "Plasma Proteins", "Positioning Attribute", "Production", "Prospective cohort", "Protein Tyrosine Kinase", "Proteins", "Proteome", "Proteomics", "Recovery", "Reproducibility", "Research Personnel", "Role", "STAT3 gene", "Sampling", "Scientist", "Sepsis", "Severities", "Signal Transduction", "Stat3 Signaling Pathway", "System", "T-Lymphocyte", "TYK2", "Testing", "Therapeutic Effect", "Time", "Training", "Translational Research", "Translations", "Validation", "Whole Blood", "cohort", "cytokine", "design", "endothelial dysfunction", "experience", "immunoregulation", "improved", "inhibitor", "learning strategy", "mortality", "multiple omics", "pediatric patients", "pediatric sepsis", "personalized approach", "precision medicine", "predict clinical outcome", "prognostic", "prospective", "randomized trial", "septic patients", "severe sepsis", "single-cell RNA sequencing", "skills", "supportive environment", "trait", "transcription factor" ], "approved": true } }, { "type": "Grant", "id": "14338", "attributes": { "award_id": "5R01MH133226-02", "title": "Leveraging Noninvasive Transcutaneous Vagus Nerve Stimulation and Smartphone Technology to Reduce Suicidal Behaviors and Suicide Among Highly Vulnerable Adolescents", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10326, "first_name": "Christopher S.", "last_name": "Sarampote", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2027-07-31", "award_amount": 750392, "principal_investigator": { "id": 26523, "first_name": "Theodore Patrick", "last_name": "Beauchaine", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26524, "first_name": "Arielle Hope", "last_name": "Sheftall", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26525, "first_name": "Kristin", "last_name": "Valentino", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 171, "ror": "https://ror.org/00mkhxb43", "name": "University of Notre Dame", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Over the past two decades, suicide rates have increased nearly 35% in the U.S., with up- ward trends in nearly all demographic groups. Further increases have occurred since the COVID-19 pandemic began. Despite ambitious goals for reducing suicides and significant fed- eral and private investment, suicide rates continue to rise unabated. To date, the predominant approach to mitigating suicide risk in the U.S. is secondary prevention. Typically, these pro- grams identify risk of recurrence among those who have already attempted suicide at least once. Although secondary prevention is crucial, the majority of deaths by suicide occur on first attempt. Thus, targeted primary prevention earlier in development is essential. Most current pri- mary prevention programs are intensive, expensive, and delivered by highly trained mental health providers, who are in short supply. Traditional face-to-face therapy is also unavailable to many who live in underserved communities, and disliked by adolescents, who much prefer digi- tal delivery on their devices. This high-risk, high-reward proposal addresses these limitations and needs. We use an experimental therapeutics approach to evaluate the independent and combined efficacies of two unconventional but scalable interventions: transcutaneous vagus nerve stimulation (tVNS) to target emotion dysregulation, and a peer-support smartphone app to combat social isolation. These low-cost interventions, which hold strong promise but have not been used before, can reach large numbers of adolescents, with much potential to reduce pro- spective suicide risk. We will enroll 212 adolescents, ages 13-17 years, who show elevations on at least two prominent risk factors for suicide (e.g., self-injury, maltreatment). Using a 2 × 2 de- sign, adolescents will be assigned randomly to receive 30 days of treatment with (1) tVNS to tar- get emotion dysregulation, (2) a peer-support phone app to target social isolation, (3) tVNS + a peer-support phone app, or (4) enhanced treatment as usual with monitoring and access to re- sources. Intervention effects on mechanisms (emotion dysregulation, social isolation) proximal efficacy signals (e.g., physiological reactivity, self-harm) and target outcomes (suicidal ideation, suicidal behaviors) will be evaluated immediately post-intervention and at one-year follow-up. Treatment data will be monitored daily to fine-tune dosing of both interventions. This transforma- tive and innovative proposal tests two novel, scalable preventive interventions designed to “meet adolescents where they are\" by using digital technologies to address core mechanisms of suicide risk.", "keywords": [ "17 year old", "Acceleration", "Adaptive Behaviors", "Address", "Adolescence", "Adolescent", "Age", "Biosensor", "Brain", "COVID-19 pandemic", "Cause of Death", "Cellular Phone", "Data", "Depressed mood", "Detection", "Development", "Devices", "Dose", "Ear", "Effectiveness", "Emotional", "Emotions", "Enrollment", "Family", "Feeling suicidal", "Fright", "Future", "Goals", "Health Personnel", "Hospitalization", "Intervention", "Investigational Therapies", "Investments", "Loneliness", "Mental Depression", "Mental Health", "Monitor", "Music", "National Institute of Mental Health", "Outcome", "Patient Self-Report", "Physiological", "Population", "Prevention", "Prevention approach", "Prevention program", "Preventive service", "Primary Prevention", "Privatization", "Protocols documentation", "Public Health", "Randomized", "Recording of previous events", "Recurrence", "Reporting", "Resources", "Risk", "Risk Factors", "Rural", "Secondary Prevention", "Secure", "Self-Injurious Behavior", "Sensitivity and Specificity", "Services", "Signal Transduction", "Social isolation", "Stimulus", "Structure", "Suicide", "Suicide attempt", "Suicide prevention", "Technology", "Telephone", "Testing", "Training", "Vagus nerve structure", "Youth", "combat", "cost", "design", "digital", "digital delivery", "digital technology", "emotion dysregulation", "emotion regulation", "follow-up", "high reward", "high risk", "high risk behavior", "improved", "innovation", "innovative technologies", "insight", "intervention cost", "intervention delivery", "intervention effect", "maltreatment", "mental training", "negative affect", "neighborhood disadvantage", "neural", "novel", "peer", "peer support", "positive emotional state", "post intervention", "preference", "preventive intervention", "programs", "prospective", "recruit", "reducing suicide", "response", "satisfaction", "scale up", "smartphone application", "social", "suicidal", "suicidal adolescent", "suicidal behavior", "suicidal morbidity", "suicidal risk", "suicide rate", "therapy design", "treatment as usual", "treatment duration", "trend", "underserved community", "vagus nerve stimulation", "vulnerable adolescent" ], "approved": true } }, { "type": "Grant", "id": "10515", "attributes": { "award_id": "1R01MH133226-01", "title": "Leveraging Noninvasive Transcutaneous Vagus Nerve Stimulation and Smartphone Technology to Reduce Suicidal Behaviors and Suicide Among Highly Vulnerable Adolescents", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10326, "first_name": "Christopher S.", "last_name": "Sarampote", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2027-07-31", "award_amount": 1014872, "principal_investigator": { "id": 26523, "first_name": "Theodore Patrick", "last_name": "Beauchaine", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26524, "first_name": "Arielle Hope", "last_name": "Sheftall", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26525, "first_name": "Kristin", "last_name": "Valentino", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 171, "ror": "https://ror.org/00mkhxb43", "name": "University of Notre Dame", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Over the past two decades, suicide rates have increased nearly 35% in the U.S., with up- ward trends in nearly all demographic groups. Further increases have occurred since the COVID-19 pandemic began. Despite ambitious goals for reducing suicides and significant fed- eral and private investment, suicide rates continue to rise unabated. To date, the predominant approach to mitigating suicide risk in the U.S. is secondary prevention. Typically, these pro- grams identify risk of recurrence among those who have already attempted suicide at least once. Although secondary prevention is crucial, the majority of deaths by suicide occur on first attempt. Thus, targeted primary prevention earlier in development is essential. Most current pri- mary prevention programs are intensive, expensive, and delivered by highly trained mental health providers, who are in short supply. Traditional face-to-face therapy is also unavailable to many who live in underserved communities, and disliked by adolescents, who much prefer digi- tal delivery on their devices. This high-risk, high-reward proposal addresses these limitations and needs. We use an experimental therapeutics approach to evaluate the independent and combined efficacies of two unconventional but scalable interventions: transcutaneous vagus nerve stimulation (tVNS) to target emotion dysregulation, and a peer-support smartphone app to combat social isolation. These low-cost interventions, which hold strong promise but have not been used before, can reach large numbers of adolescents, with much potential to reduce pro- spective suicide risk. We will enroll 212 adolescents, ages 13-17 years, who show elevations on at least two prominent risk factors for suicide (e.g., self-injury, maltreatment). Using a 2 × 2 de- sign, adolescents will be assigned randomly to receive 30 days of treatment with (1) tVNS to tar- get emotion dysregulation, (2) a peer-support phone app to target social isolation, (3) tVNS + a peer-support phone app, or (4) enhanced treatment as usual with monitoring and access to re- sources. Intervention effects on mechanisms (emotion dysregulation, social isolation) proximal efficacy signals (e.g., physiological reactivity, self-harm) and target outcomes (suicidal ideation, suicidal behaviors) will be evaluated immediately post-intervention and at one-year follow-up. Treatment data will be monitored daily to fine-tune dosing of both interventions. This transforma- tive and innovative proposal tests two novel, scalable preventive interventions designed to “meet adolescents where they are\" by using digital technologies to address core mechanisms of suicide risk.", "keywords": [ "17 year old", "Address", "Adolescence", "Adolescent", "Age", "Biosensor", "Brain", "COVID-19", "COVID-19 pandemic", "Cause of Death", "Cellular Phone", "Data", "Depressed mood", "Detection", "Development", "Devices", "Dose", "Ear", "Effectiveness", "Emotional", "Emotions", "Enrollment", "Family", "Feeling suicidal", "Future", "Goals", "Health Personnel", "Intervention", "Investigational Therapies", "Investments", "Loneliness", "Mental Depression", "Mental Health", "Monitor", "Music", "National Institute of Mental Health", "Outcome", "Patient Self-Report", "Physiological", "Population", "Prevention", "Prevention approach", "Prevention program", "Preventive service", "Primary Prevention", "Privatization", "Protocols documentation", "Public Health", "Randomized", "Recording of previous events", "Recurrence", "Resources", "Risk", "Risk Factors", "Rural", "Secondary Prevention", "Secure", "Self-Injurious Behavior", "Sensitivity and Specificity", "Services", "Signal Transduction", "Social isolation", "Source", "Structure", "Suicide", "Suicide attempt", "Suicide prevention", "Technology", "Telephone", "Testing", "Training", "Vagus nerve structure", "Youth", "combat", "cost", "design", "digital", "digital delivery", "emotion dysregulation", "emotion regulation", "follow-up", "high reward", "high risk", "high risk behavior", "improved", "innovation", "innovative technologies", "insight", "intervention cost", "intervention delivery", "intervention effect", "maltreatment", "mental training", "negative affect", "neighborhood disadvantage", "novel", "peer", "peer support", "post intervention", "preference", "preventive intervention", "programs", "prospective", "recruit", "reducing suicide", "relating to nervous system", "response", "satisfaction", "scale up", "smartphone Application", "social", "suicidal", "suicidal adolescent", "suicidal behavior", "suicidal morbidity", "suicidal risk", "suicide rate", "therapy design", "treatment as usual", "treatment duration", "trend", "underserved community", "vagus nerve stimulation", "vulnerable adolescent", "ward" ], "approved": true } }, { "type": "Grant", "id": "8952", "attributes": { "award_id": "1R35GM143052-01", "title": "Structural and Functional Studies of Molecular Machines Involved in Chemical Modifications of Macromolecules", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 24785, "first_name": "ANDRE W.", "last_name": "PHILLIPS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-15", "end_date": "2026-06-30", "award_amount": 410000, "principal_investigator": { "id": 24786, "first_name": "Minglei", "last_name": "Zhao", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Our lab focuses on structural and functional studies of molecular machines involved in chemical modifications of macromolecules. Naturally occurring chemical modifications of macromolecules play essential roles in all aspects of molecular biology, from transcriptional and translational regulation to functional modulation of various proteins. Misregulation of the chemical modifications is involved in many human diseases such as cancers and neurodegenerative diseases. Although many have been described and characterized, there are still significant amounts of chemical modification systems that are poorly understood. Our long term goal is to elucidate the structure and function of molecular machines involved in various chemical modification systems and develop new tools and strategies to modulate their activity against the relevant diseases based on what we have learned. In the next five years, we will be focusing on two systems, the p97 related ubiquitination system and the Vault related ADP-ribosylation system. More than thirty mutations of human p97 have been identified, which are associated with a number of neurodegenerative diseases. The molecular mechanism, however, remains elusive. Through structural biology approaches and protein engineering, we will address 1) how p97 processes ubiquitin chains of different topologies through the cofactors; 2) the structural and functional consequences of disease mutations; 3) the mechanism of inhibitors of p97 and its cofactors. Our efforts promise unprecedented insights into the function of p97, a central hub of cellular protein homeostasis. Vault is the largest ribonucleoprotein in eukaryotic cells with a unique structure. The function of Vault has been linked to drug resistance in cancer and innate immune response. Recently, major vault protein (MVP) was identified as one of the 9 marker genes that can predict influenza vaccination responses. Given the importance of vaccine development during this COVID-19 pandemic, a deep understanding of Vault’s molecular mechanism is critical. We are going to focus on PARP4, the only enzyme in the Vault complex catalyzing ADP-ribosylation. Elucidating the function of PARP4 and how it interacts with Vault particle is the key to understand the molecular function of Vault.", "keywords": [ "ADP ribosylation", "Address", "Adopted", "Biology", "COVID-19 pandemic", "Chemicals", "Complex", "Disease", "Drug resistance", "Enzymes", "Eukaryotic Cell", "Genes", "Goals", "Human", "Influenza vaccination", "Innate Immune Response", "Link", "Malignant Neoplasms", "Methods", "Modification", "Molecular", "Molecular Biology", "Molecular Machines", "Mutation", "Neurodegenerative Disorders", "Play", "Process", "Protein Engineering", "Proteins", "Ribonucleoproteins", "Role", "Structure", "System", "Transcriptional Regulation", "Translational Regulation", "Ubiquitin", "Ubiquitination", "base", "cofactor", "human disease", "inhibitor/antagonist", "insight", "macromolecule", "major vault protein", "particle", "proteostasis", "response", "structural biology", "tool", "vaccine development" ], "approved": true } }, { "type": "Grant", "id": "15002", "attributes": { "award_id": "5R01AI177010-02", "title": "Retaining relevance: extending clinical retention measures to improve their utility in describing HIV care engagement in the United States", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6828, "first_name": "Rosemary G", "last_name": "McKaig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-20", "end_date": "2028-06-30", "award_amount": 630091, "principal_investigator": { "id": 22255, "first_name": "Keri Nicole", "last_name": "Althoff", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 27401, "first_name": "Peter F", "last_name": "Rebeiro", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract HIV remains a major public health concern in the United States. The proportions of people with HIV (PWH) in 2020 who knew their HIV status, were linked to care, retained in clinical care (50%), and had suppressed viral loads (57%), were lackluster. Retention in clinical care is a core quality-of-care indicator and the central stage of the HIV care continuum. Suboptimal clinical retention is strongly associated with virologic failure while on ART, high-risk behavior, and poorer survival. Furthermore, it is estimated that 43% of new HIV transmissions are from PWH who are out of care (the largest proportion from any one care continuum stage). The implication, echoed in multiple public health policies over the past decade, is that high retention and engagement in clinical care are critical for blunting the HIV-related morbidity and mortality and reducing the number of new HIV infections. However, despite consensus that “retention” in care is critical and “engagement” in care must be increased, we do not fully understand how best to measure retention and engagement among patients in high-income settings, particularly in the modern ART era and given changes in care delivery that were introduced during the COVID-19 pandemic. Earlier research indicated that sicker patients (i.e., those with lower CD4) were more likely to miss clinic visits. More recent work, though, found that patients attending clinic visits less frequently may continue to receive laboratory monitoring services; this could well be an indication that healthier patients (i.e., those with higher CD4) who are stably virally suppressed are compliant with newer monitoring guidelines which demand less frequent clinic visits. However, the field has yet to delineate the optimal frequency of clinic visits for these healthier, virally suppressed patients as opposed to individuals in multiple other risk strata, though applying a single metric regardless of sub-population could produce spurious findings of poor retention among clinically stable individuals. In this respect, our proposal is truly novel. The proposed research will therefore extract, harmonize, and analyze readily available data on clinical care patterns within the largest HIV cohort in North America: the North American AIDS Cohort Collaboration on Research and Design. We will use these data to describe patterns of retention and engagement (Aim 1), isolate multiple measures of care receipt (Aims 1 and 2) that predict improved survival and viral suppression, and assess multiple methods for stratifying populations while quantifying the expected causal impact of improved retention on HIV outcomes under existing and novel, optimized metrics (Aim 3). The public health impact of improved retention metrics, based on population-specific HIV clinical care engagement, would be profound, particularly in light of changes in HIV disease and comorbidity clinical management and laboratory monitoring under a primary care model, as well as changing care modalities during the COVID-19 pandemic. This proposal therefore holds unique promise, enabling improved HIV care continuum measurement in the US.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12003", "attributes": { "award_id": "1R01AI177010-01A1", "title": "Retaining relevance: extending clinical retention measures to improve their utility in describing HIV care engagement in the United States", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6828, "first_name": "Rosemary G", "last_name": "McKaig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-20", "end_date": "2028-06-30", "award_amount": 681131, "principal_investigator": { "id": 22255, "first_name": "Keri Nicole", "last_name": "Althoff", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 27401, "first_name": "Peter F", "last_name": "Rebeiro", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract HIV remains a major public health concern in the United States. The proportions of people with HIV (PWH) in 2020 who knew their HIV status, were linked to care, retained in clinical care (50%), and had suppressed viral loads (57%), were lackluster. Retention in clinical care is a core quality-of-care indicator and the central stage of the HIV care continuum. Suboptimal clinical retention is strongly associated with virologic failure while on ART, high-risk behavior, and poorer survival. Furthermore, it is estimated that 43% of new HIV transmissions are from PWH who are out of care (the largest proportion from any one care continuum stage). The implication, echoed in multiple public health policies over the past decade, is that high retention and engagement in clinical care are critical for blunting the HIV-related morbidity and mortality and reducing the number of new HIV infections. However, despite consensus that “retention” in care is critical and “engagement” in care must be increased, we do not fully understand how best to measure retention and engagement among patients in high-income settings, particularly in the modern ART era and given changes in care delivery that were introduced during the COVID-19 pandemic. Earlier research indicated that sicker patients (i.e., those with lower CD4) were more likely to miss clinic visits. More recent work, though, found that patients attending clinic visits less frequently may continue to receive laboratory monitoring services; this could well be an indication that healthier patients (i.e., those with higher CD4) who are stably virally suppressed are compliant with newer monitoring guidelines which demand less frequent clinic visits. However, the field has yet to delineate the optimal frequency of clinic visits for these healthier, virally suppressed patients as opposed to individuals in multiple other risk strata, though applying a single metric regardless of sub-population could produce spurious findings of poor retention among clinically stable individuals. In this respect, our proposal is truly novel. The proposed research will therefore extract, harmonize, and analyze readily available data on clinical care patterns within the largest HIV cohort in North America: the North American AIDS Cohort Collaboration on Research and Design. We will use these data to describe patterns of retention and engagement (Aim 1), isolate multiple measures of care receipt (Aims 1 and 2) that predict improved survival and viral suppression, and assess multiple methods for stratifying populations while quantifying the expected causal impact of improved retention on HIV outcomes under existing and novel, optimized metrics (Aim 3). The public health impact of improved retention metrics, based on population-specific HIV clinical care engagement, would be profound, particularly in light of changes in HIV disease and comorbidity clinical management and laboratory monitoring under a primary care model, as well as changing care modalities during the COVID-19 pandemic. This proposal therefore holds unique promise, enabling improved HIV care continuum measurement in the US.", "keywords": [ "Acquired Immunodeficiency Syndrome", "American", "Benchmarking", "Black Populations", "CD4 Lymphocyte Count", "COVID-19 pandemic", "Caring", "Categories", "Cells", "Classification", "Clinic Visits", "Clinical", "Clinical Management", "Collaborations", "Consensus", "Continuity of Patient Care", "Critical Care", "Data", "Disease", "Disease Management", "Disease Outcome", "Disparity", "Ethnic Origin", "Failure", "Frequencies", "Growth", "Guidelines", "HIV", "HIV Infections", "HIV disparities", "HIV-1", "Health Policy", "Hispanic Populations", "Income", "Individual", "Laboratories", "Light", "Link", "Measurement", "Measures", "Methods", "Modality", "Modeling", "Modernization", "Monitor", "Morbidity - disease rate", "North America", "Outcome", "Patients", "Pattern", "Patterns of Care", "Persons", "Policies", "Population", "Primary Care", "Public Health", "Quality of Care", "RNA", "Race", "Recommendation", "Research", "Risk", "Services", "Techniques", "Time", "United States", "Update", "Viral", "Viral Load result", "Visit", "Work", "care delivery", "clinical care", "cohort", "comorbidity", "design", "eVisit", "epidemiological model", "experience", "health disparity", "high risk behavior", "improved", "men who have sex with men", "mortality", "novel", "population stratification", "primary care visit", "programs", "public health relevance", "sexual risk behavior", "telehealth", "theories", "transmission process" ], "approved": true } } ], "meta": { "pagination": { "page": 1405, "pages": 1424, "count": 14236 } } }