Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1404&sort=awardee_organization
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=awardee_organization", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=awardee_organization", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=awardee_organization", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1403&sort=awardee_organization" }, "data": [ { "type": "Grant", "id": "15551", "attributes": { "award_id": "75N95024D00006-P00001-759502400001-1", "title": "TO1 - STSS PROGRAM SUPPORT 1.0", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Advancing Translational Sciences (NCATS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2024-02-08", "end_date": "2024-05-31", "award_amount": 10367151, "principal_investigator": { "id": 26488, "first_name": "GARY", "last_name": "MAYS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2550, "ror": "", "name": "AXLE INFORMATICS, LLC", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "National COVID-19 Cohort Collaborative (N3C): The National COVID-19 Cohort Collaborative (N3C) sponsors the NIH COVID-19 Data Enclave, one of the largest data enclaves in the world supporting COVID-19 research. N3C is a partnership among the NCATS-supported Clinical and Translational Science Awards (CTSA) Program hubs, with overall stewardship by NCATS. The N3C program consists of thousands of researchers, requiring enterprise level information technology (IT) support as part of a virtual research organization (VRO). This contract is necessary to ensure that NCATS and N3C can continue to provide adequate support for a secure, collaborative, VRO. This contract allows for continued support of the VRO which supports all of the required information technology functions to support an environment of over 4,000 users, including cloud-based productivity tools, a service desk, commercial and open-source deployments of analytical tools for the community to use, and expansion of the data types available for analysis, such as imaging, viral variant genomic sequences, etc. The common need is to share a collaborative cloud environment capable of ingesting billions of data points and performing a variety of complex analyses against multimodal data types, ranging from pathology and radiology data, synthetic data, genomic information, electronic health records (EHRs) and a wide variety of others. All of this must be done while meeting the highest levels of security and privacy, given the sensitivity of some of the data types being collected and the importance of the work being done in the environment. This contract provides support for all of these enterprise IT efforts.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15627", "attributes": { "award_id": "1R43GM157920-01", "title": "Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 31602, "first_name": "Sailaja", "last_name": "Koduri", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-01-01", "end_date": "2025-06-30", "award_amount": 306873, "principal_investigator": { "id": 32127, "first_name": "Po-Lun", "last_name": "Feng", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2551, "ror": "", "name": "OSEM FLUIDICS INC", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has established the importance of nucleic acid-based lipid nanoparticles (LNPs) for the future of global health. The benefits of lipid nanoparticles are multifaceted as they protect sensitive pharmaceutical payloads from enzymatic degradation and allow for the modification of solubility, release kinetics, and bioavailability. While chemical formulation of LNPs has been widely explored, the effects of manufacturing—specifically microfluidics processing—are not currently well-understood. This knowledge gap presents challenges in the production of intricate nanoparticle structures, which require specialized microfluidic systems that produce well-defined and reproducible flow configurations. The proposed research focuses on developing 3D-printed channel architectures to precisely control LNP structure and properties to enhance transfection efficiency without modifying their chemical composition. Aim 1 involves designing, simulating, and testing various 3D channel architectures to manipulate flow conditions and tailor LNP properties. Aim 2 focuses on structural determination via SAXS and CryoTEM, and assesses the impact of LNP structures on mRNA transfection efficiency through in vitro transfection studies. Aim 3 will demonstrate the therapeutic- and disease-agnostic design workflow by robustly encapsulating siRNA and pDNA. This project aims to overcome the limitations of current LNP manufacturing methods which are constrained by fixed geometries and limited control over LNP assembly processes. Development of our enabling technology will offer an additional process parameter - channel architecture, for tuning LNP properties and structure in a rapid and customizable manner that is broadly applicable.", "keywords": [ "3-Dimensional", "3D Print", "Acceleration", "Address", "Affect", "Architecture", "Biological Availability", "COVID-19", "COVID-19 pandemic", "COVID-19 vaccine", "Characteristics", "Chemicals", "Chemistry", "Cholesterol", "Complex", "Development", "Devices", "Disease", "Encapsulated", "Formulation", "Foundations", "Future", "Gene Delivery", "Gene Expression", "Geometry", "Image", "In Vitro", "Kinetics", "Knowledge", "Lipids", "Liquid substance", "Messenger RNA", "Methods", "Microfabrication", "Microfluidic Microchips", "Microfluidics", "Modality", "Modification", "Nucleic Acids", "Outcome", "Pharmacologic Substance", "Phase", "Process", "Production", "Property", "Reproducibility", "Research", "Research Personnel", "Roentgen Rays", "Route", "SARS-CoV-2 spike protein", "Series", "Small Interfering RNA", "Solubility", "Structure", "System", "Technology", "Testing", "Therapeutic", "Time", "Transfection", "United States National Institutes of Health", "clinically relevant", "cost", "design", "experimental study", "fabrication", "fluid flow", "global health", "improved", "in vivo", "innovation", "interest", "lipid nanoparticle", "mRNA lipid nano particle vaccine", "manufacture", "manufacturing systems", "millimeter", "nanoparticle", "novel", "novel therapeutics", "nucleic acid delivery", "nucleic acid structure", "nucleic acid-based therapeutics", "operation", "particle", "pre-clinical", "prevent", "spatiotemporal", "therapeutic development", "tool" ], "approved": true } }, { "type": "Grant", "id": "15649", "attributes": { "award_id": "2451399", "title": "SBIR Phase I: Novel Peptide Immunomodulators for Treatment of Autoimmune and Inflammatory Disorders", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "SBIR Phase I" ], "program_reference_codes": [], "program_officials": [ { "id": 936, "first_name": "Henry", "last_name": "Ahn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-03-01", "end_date": null, "award_amount": 305000, "principal_investigator": { "id": 32152, "first_name": "Masha", "last_name": "Fridkis-Hareli", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2552, "ror": "", "name": "PALENA THERAPEUTICS, INC.", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is in developing a novel class of compounds capable of treating autoimmune and inflammatory conditions safely and effectively. With the constant threat of new COVID variants, influenza, and RSV, there is an unmet medical need for therapeutics that can effectively treat autoimmune diseases especially in pediatric patients without compromising the immune system to respond to infections. This problem has been overcome with the discovery of novel compositions that demonstrate efficacy equal or superior to many of the first line therapies used to treat immune diseases. The improved safety, efficacy and lower cost of these therapeutics should provide a significant benefit to patients by overall contributing to their quality of life as compared to current medications, as well as marketing and partnering advantage in its commercialization efforts, which will focus on rare diseases, such as juvenile idiopathic arthritis-associated uveitis and pediatric Crohn’s disease among others. In the era of socio-economic disparities, these affordable drugs will become available to the historically neglected low-income communities. If executed successfully, this proposal would validate the platform technology and demonstrate the feasibility of identifying candidates for further development into life-changing treatments. This Small Business Innovation Research (SBIR) Phase I project will demonstrate the unique design of novel compounds to augment and re-program the immune responses from pro- to anti-inflammatory, based on the binding to MHC class II molecules that leads to immunomodulation. The technical complexities of understanding the effects of peptide sequences on the outcomes of cellular interactions present challenges related to selecting the appropriate amino acids both for the random and specific components of these compositions. These hurdles will be addressed by design of several candidate compounds for each target condition, juvenile idiopathic arthritis-associated uveitis and pediatric Crohn’s disease, that will take into account the structure of autoantigenic peptides known to interact with both the MHC class II and T cell receptor (TCR). These candidate compounds will be initially tested in vitro in human macrophages to assess their potential to inhibit secretion of pro-inflammatory cytokines. Of these compounds, the most efficient ones will be tested for activity in relevant animal models. This approach will allow identifying and selecting the best drug candidates for further development into therapies for pediatric conditions as outlined above. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15680", "attributes": { "award_id": "2508854", "title": "Postdoctoral Fellowship: PRFB: How host immunity drives the evolution of pathogen virulence", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Biology Postdoctoral Research" ], "program_reference_codes": [], "program_officials": [ { "id": 30092, "first_name": "Joel", "last_name": "Abraham", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-07-01", "end_date": null, "award_amount": 270000, "principal_investigator": { "id": 32526, "first_name": "Michael", "last_name": "Blazanin", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2603, "ror": "", "name": "Blazanin, Michael", "address": "", "city": "", "state": "", "zip": "", "country": "CA", "approved": true }, "abstract": "This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2025. The fellowship supports research and training of the fellow that will contribute to biology in innovative ways. This research will improve our understanding of how pathogens evolve. More clearly than ever following the COVID-19 pandemic, pathogens can evolve extremely rapidly with global impacts. One of the most important ways that pathogens evolve is in their virulence, the harm they inflict upon their hosts. Understanding and predicting how pathogen virulence will evolve is paramount for fields from vaccine design to epidemiology, agriculture, and healthcare. The evolution of virulence can be shaped by numerous factors, but one of the most important factors that every pathogen interacts with is the host’s immune system. This project will test how immunity influences pathogen evolution, using experimental and simulation methodologies to build a predictive understanding of how pathogen virulence is shaped by the host immune system. The results of this research have broad implications, including for public health. This fellowship will also support mentorship, training, and education for undergraduate and graduate students. To test how immunity influences pathogen evolution, this project will use mathematical models and laboratory experiments. It aims to answer two questions: 1) how do different parts of the immune system individually shape pathogen virulence evolution, and 2) how does variation in immunity between hosts in a population shape pathogen virulence evolution. To answer these questions, this project leverages an extremely powerful laboratory model system: Caenorhabditis elegans nematodes. These nematodes are easy to experiment with, and their innate immune system shares many similarities with mammals. In this research, C. elegans will be experimentally infected with a widespread bacterial pathogen, Pseudomonas aeruginosa, to directly observe how Pseudomonas evolves depending on the immune state of C. elegans. Experimental measurements will be integrated with mathematical models to directly test how well model predictions match experimental outcomes. Through the course of this fellowship training, the fellow will develop expertise with C. elegans-bacteria systems, build essential bioinformatic skills, and gain experience with evolutionary modeling. The broader impacts of this project include potential applications in public health policy and vaccine design, mentorship and hands-on research training for undergraduate students, development of a peer mentorship program for graduate students, and instructional modules that integrate research into undergraduate education. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15699", "attributes": { "award_id": "1R43AR084352-01A1", "title": "Use of HIF-1alpha mRNA to Promote Pedicle Flap Healing.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 32563, "first_name": "XIBIN", "last_name": "WANG", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 296256, "principal_investigator": { "id": 32564, "first_name": "John M", "last_name": "Abraham", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2604, "ror": "", "name": "ADVANCED MOLECULAR HEALIX INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Summary/Abstract. Surgical debridement is often used when treating major wounds, and pedicle flaps are a critical component in subsequent surgical reconstructions. Distal portions of the flap require vascular perfusion for overall success of wound repair and reconstruction. Hypoxia-inducible factor-1α (HIF-1α) is an important inducible transcription factor that orchestrates and controls cellular responses to hypoxia when paired with constitutively expressed HIF-1. HIF-1α enhances cell survival in wounds by regulating the expression of over 200 genes, including many angiogenic growth factors responsible for restoration of vascular beds. By combining the concept of increasing HIF-1α in wounds to promote cell survival and revascularization, with contemporary approaches for RNA transduction pioneered in COVID vaccines, our goal is to create a novel therapeutic strategy for enhancing pedicle flap survival. Experiments that support progress toward this goal are proposed in two specific aims: Specific Aim 1A: Quantitation of HIF-1α mRNA and response genes following intradermal injection in Sprague Dawley rats. Based on encouraging preliminary results both in vitro and in vivo, we are developing new versions of our HIF-1 mRNA reagents that are designed to improve activity when delivered in vivo using a proprietary lipid nanoparticle carrier. Rat and porcine versions of our HIF-1 mRNA reagents are being developed for use in pedicle flap assays described in Aims 1B and 2. Specific Aim 1B: In vivo assessment of HIF-1α mRNA therapeutics in a Sprague Dawley rat model of pedicle flap surgery. Findings in Aim 1A will provide preliminary data on best performing reagent structures, dose, and delivery formulations to inform testing in pedicle flap assays in male and female rats. In this aim we will measure HIF-1 expression and downstream gene induction as in Aim1A and add macroscopic monitoring of wound resolution and molecular phenotyping of the wound site using quantitative PCR and immunohistochemistry. Specific Aim 2: In vivo assessment of HIF-1α mRNA therapeutics in a porcine model of pedicle flap surgery. Pigs are valuable preclinical models for testing novel wound healing strategies. The mRNA reagents and formulations that show promise in the rat pedicle flap model in Aim 1B will subsequently be tested in a porcine model of pedicle flap survival and wound healing. Surgical outcomes will be assayed as in Aim 1B to monitor potential translatability of our studies for human clinical applications.", "keywords": [ "3&apos", "Untranslated Regions", "Applications Grants", "Award", "Binding Sites", "Biological Assay", "Blood Vessels", "Breast", "COVID-19 vaccine", "Cell Survival", "Clinical", "Complex", "Coupled", "DNA", "Data", "Debridement", "Development", "Distal", "Dose", "Excision", "Failure", "Family suidae", "Female", "Formulation", "Future", "Gene Activation", "Genes", "Goals", "Grant", "Growth Factor", "HIF1A gene", "Hernia of abdominal cavity", "Histopathology", "Human", "Hypoxia", "Hypoxia Inducible Factor", "Immunohistochemistry", "In Vitro", "Infection", "Inflammation", "Injections", "Injury", "Ischemia", "Measures", "Messenger RNA", "Methods", "MicroRNAs", "Military Personnel", "Modeling", "Molecular", "Monitor", "Mutation", "Natural regeneration", "Necrosis", "Operative Surgical Procedures", "Patients", "Perfusion", "Phase", "Plastic Surgical Procedures", "Pre-Clinical Model", "Preclinical Testing", "Preparation", "Procedures", "Protocols documentation", "Pseudouridine", "RNA", "RNA vaccine", "Rattus", "Reagent", "Reconstructive Surgical Procedures", "Resolution", "Rodent Model", "Site", "Skin", "Small Business Innovation Research Grant", "Sprague-Dawley Rats", "Standardization", "Structure", "Surgical Flaps", "System", "Testing", "Therapeutic", "Toxicology", "Translational Repression", "Traumatic injury", "Variant", "cancer surgery", "clinical application", "delivery vehicle", "design", "enhancing factor", "experimental study", "gene induction", "healing", "hypoxia inducible factor 1", "improved", "in vivo", "intradermal injection", "lipid nanoparticle", "male", "molecular phenotype", "nanolipoprotein particles", "nanoparticle delivery", "next generation", "novel", "novel therapeutic intervention", "novel therapeutics", "pharmacokinetics and pharmacodynamics", "porcine model", "preclinical study", "protein degradation", "reconstruction", "repaired", "research clinical testing", "response", "restoration", "revascularization", "success", "surgery outcome", "therapeutic evaluation", "tissue oxygenation", "transcription factor", "vascular bed", "vector", "wound", "wound care", "wound healing", "wound treatment" ], "approved": true } }, { "type": "Grant", "id": "15721", "attributes": { "award_id": "2528179", "title": "STTR Phase I: Room Temperature Stable, Dry Powder Particle-Based Vaccines Against Influenza", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "STTR Phase I" ], "program_reference_codes": [], "program_officials": [ { "id": 936, "first_name": "Henry", "last_name": "Ahn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-10-01", "end_date": null, "award_amount": 305000, "principal_investigator": { "id": 32602, "first_name": "Sean", "last_name": "Kelly", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32601, "first_name": "Kathleen", "last_name": "Ross", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2605, "ror": "", "name": "IMMUNO NANO MED, INC", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to demonstrate room-temperature-stable, dry powder inhalable influenza vaccines represent as an innovative, next generation technology to promote the health and welfare of the American public by eliminating the existing pain points of current influenza vaccines. The global influenza vaccine market size is projected to increase to $17.77 billion by 2032. Therefore, the demand for innovative vaccines against seasonal respiratory viruses remains a high priority. These dry powder vaccines introduce a transformative innovation – induction of durable protective immunity that targets both the upper and lower airways via nasal delivery and removing the cold chain due to room-temperature shelf stability, thereby lowering vaccine costs and wastage. This outcome can result in cost savings of up to 80%. The economic and social benefits of this vaccine technology will lead to achieving and maintaining a significant market share of the flu vaccine market. Additionally, this technology’s plug-and-play capability allows swapping pathogen-specific proteins and creating new inhalable room-temperature-stable vaccines for other respiratory pathogens. Altogether, this advance will significantly lower storage costs while improving our nation’s strategic preparedness in stockpiling vaccines against circulating disease, emerging threats, or biowarfare agents. This Small Business Technology Transfer (STTR) Phase I project will demonstrate the feasibility of producing a novel room-temperature-stable, dry-powder inhalable influenza vaccine and using a new scalable process to manufacture the vaccine. Current flu shots do not provide lung-specific immune responses and require refrigerated storage. This project’s value proposition is to replace current needle-in-the-arm, partially effective flu shots with next-generation vaccines and delivery methods. This project enables the risk-reducing R&D needed to advance a dry powder vaccine manufacturing technology called Payload Reduction and Encapsulation Technology (PRET). The goal is to demonstrate feasibility of this manufacturing method by showing dry powder influenza vaccines synthesized by PRET result in reproducible dry powder vaccine characteristics, high vaccine yields, protection against influenza infection, and room-temperature shelf stability. There are three objectives that will be pursued to demonstrate this: 1) feasibility of achieving initial pilot-scale production and characterization of dry powder influenza vaccines using PRET; 2) dry powder influenza vaccine efficacy compared to traditional flu vaccines; and 3) production of influenza particle-based vaccines using scaled-up engineering runs and evaluation of room-temperature shelf-life. The new paradigm represented by room-temperature-stable, dry powder vaccines has the potential to transform the vaccine-delivery landscape and enhance the nation’s pandemic preparedness. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15722", "attributes": { "award_id": "2449985", "title": "Strengthening Rural STEM Education: An Evidence-Based Framework for Increasing Student Success", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "HSI-Hispanic Serving Instituti" ], "program_reference_codes": [], "program_officials": [ { "id": 1859, "first_name": "Mike", "last_name": "Ferrara", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-10-01", "end_date": null, "award_amount": 2100000, "principal_investigator": { "id": 32769, "first_name": "Jessica", "last_name": "Black", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32766, "first_name": "Melissa", "last_name": "Haeffner", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32767, "first_name": "Alexander", "last_name": "Alexiades", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32768, "first_name": "SaraBecca", "last_name": "Martin", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2606, "ror": "", "name": "Heritage University", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "With support from the Improving Undergraduate STEM Education: Hispanic-Serving Institutions (HSI Program), this Institutional Transformation project aims to develop and implement a comprehensive model for transforming STEM education at a rural institution serving local communities. The project will address academic achievement gaps in STEM fields by fostering strong STEM identities at both institutional and student levels. This work is especially timely as rural, community-based institutions face unique challenges in retaining STEM students, particularly following the COVID-19 pandemic's disproportionate impact on college-level preparedness. The project will transform institutional culture through structured dialogue between leadership and STEM stakeholders, professional development for administration, and increased leadership engagement in student-centered STEM events. Through this dual approach of institutional transformation and evidence-based teaching practices, the project will contribute new understanding of how community-based institutions can effectively support all students while preparing them for the global STEM workforce. Through innovative programming and teaching practices, this work will create a model for other institutions across the United States to follow. The project will pursue two complementary objectives: i) enhancing STEM identity in institutional leadership to transform student support networks, and ii) developing innovative experiential learning opportunities across STEM disciplines. Two primary research questions will guide this work: how backgrounds and experiences found in community-based institutions influence STEM identity development, and what knowledge transfer approaches effectively help students develop STEM identities in varied educational contexts. The project will employ multiple research methods including Photovoice documentation during international experiences, reflective student journaling, traditional storytelling approaches during research fellowships, and semi-structured interviews with institutional leaders. Specific interventions include Undergraduate Research Fellowships fostering mentored research experiences and the global interconnectedness of STEM, and comprehensive academic support systems with early intervention strategies. The project will advance the field by generating new knowledge about institutional transformation in rural higher education settings, particularly regarding the relationship between institutional STEM identity and student success. Expected broader impacts include developing a model for mutual exchange between institutional leadership and students that can inform STEM policy development at other institutions, creating a guide for building community-based programs that benefit both students and their surrounding communities in both regional and international settings, and increasing the number of STEM graduates prepared for the workforce. Results will be disseminated through publications in undergraduate education journals, conference presentations, and through the NSF HSI Program Network Resource Centers and Hubs. The HSI Program aims to enhance undergraduate STEM education and build capacity at HSIs. Projects supported by the HSI Program will also generate new knowledge on how to achieve these aims. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15723", "attributes": { "award_id": "2452299", "title": "Integrating Soft Skills with Technical Skills to Produce Next-Generation Cybersecurity Technicians", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Advanced Tech Education Prog" ], "program_reference_codes": [], "program_officials": [ { "id": 3736, "first_name": "R. Corby", "last_name": "Hovis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-10-01", "end_date": null, "award_amount": 565044, "principal_investigator": { "id": 32772, "first_name": "Alan", "last_name": "Gruver", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32770, "first_name": "Kristopher R", "last_name": "Bradshaw", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32771, "first_name": "David E", "last_name": "Oliver", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2607, "ror": "", "name": "Johnston Community College", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "This project aims to serve the national interest by producing more qualified technicians to meet workforce demands in cybersecurity. Keeping computers and information systems secure is a critical need and a major challenge in business, industry, and government. The growth of cyber-threats has created a need for many more workers who have the knowledge and skills to protect both existing and emerging technologies. Research and feedback from employers indicate that although graduates of cybersecurity programs are generally well-prepared technically, their soft skills remain underdeveloped. (This issue was exacerbated by primarily virtual interactions and remote work during the COVID-19 pandemic.) To address this gap, the investigators intend to integrate the targeted development of soft skills into core cybersecurity courses through structured team-based activities, simulations, and competition-style challenges. The project will focus on five competencies that cybersecurity professionals need in the workplace: communication, critical thinking, problem-solving, continuous learning, and attention to detail. The Business & Industry Leadership Team (BILT) that advises the college's cybersecurity program prioritized these soft skills for attention. The project team will directly embed them into course activities, assignments, and assessments. Specifically, the investigators aim to revise four existing cybersecurity courses -- Introduction to Cyber Crime, Introduction to Protocol Analysis, Security Administration, and Ethical Hacking with Python I -- to include mini-modules and challenge-based team assignments focusing on soft skills. Each course will focus on one or two of the five targeted soft skills, ensuring that each one is addressed in-depth within a technical context. Examples include group-based incident response briefings to strengthen communication and professionalism; packet analysis and network troubleshooting activities completed in teams to promote teamwork and problem-solving; and adaptive policy response scenarios that encourage flexibility and resilience. Each course will include clear learning outcomes, soft skill rubrics, and feedback mechanisms to assess both technical and interpersonal development. In addition, the investigators aim to establish a student cybersecurity competition team as a co-curricular activity and to bring elements of cyber-competition into the classroom for all students. Those activities will include in-class simulations modeled on capture-the-flag or red team/blue team competitions; structured team challenges with rotating roles to develop communication and adaptability; and opportunities for reflection and instructor feedback following simulations or live drills. By embedding a focused set of soft skills into core technical coursework and grounding students' experience in competition-style, gamified team activities, the redesigned cybersecurity program will provide a coherent, high-impact approach to cybersecurity education that aligns with workforce needs and promotes student success. This project is funded by the Advanced Technological Education program, which focuses on the education of technicians for the advanced-technology fields that drive the nation's economy. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15737", "attributes": { "award_id": "2534132", "title": "HBCU-UP RAPID: HBCU Leadership Crisis on STEM Broadening Participation and Research Capacity Building - Impact and Implications", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Hist Black Colleges and Univ" ], "program_reference_codes": [], "program_officials": [ { "id": 1154, "first_name": "Carleitta", "last_name": "Paige-Anderson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-02-15", "end_date": null, "award_amount": 199999, "principal_investigator": { "id": 4514, "first_name": "Trina", "last_name": "Fletcher", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 207, "ror": "https://ror.org/02gz6gg07", "name": "Florida International University", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 2608, "ror": "", "name": "University of Arkansas at Pine Bluff", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "The Historically Black Colleges and Universities - Undergraduate Program (HBCU-UP) supports RAPID projects when there is an urgency concerning the availability of, or access to, data, facilities, or specialized equipment, including quick-response research on natural or anthropogenic disasters and similar unanticipated events, such as the COVID-19 pandemic. During and after the COVID-19 pandemic, several higher education institutions experienced changes in the president and chancellor positions. For Historically Black Colleges and Universities (HBCUs), in 2022 alone, there were 23 leadership changes announced, and in 2023, 41 changes were announced, almost double within one year. Essentially, one in four HBCUs experienced a resignation or termination at the highest administrative level. These leadership changes have been an added challenge to the ongoing recovery efforts of many HBCUs that were also disproportionately impacted by the global pandemic. HBCUs are critical for science, technology, engineering, and mathematics (STEM) education and workforce development and for their contributions to STEM research. HBCUs are critical players in helping the nation stay competitive globally and are a national asset, considering the large numbers of diverse students earning degrees in STEM from HBCUs. Unfortunately, excessive executive leadership turnover could negatively impact those efforts. This research study will explore the institutional impact of turnover at the President/Chancellor and executive cabinet levels at HBCUs. By using pilot data collected at one of the largest annual convenings of HBCU executives related to the impact and implications of HBCU leadership turnover, our proposed convening to collect rich qualitative data, and their feedback on the pilot survey results, will dynamically and strategically gain insight on this unprecedented challenge. This project will contribute to better understanding the impacts of leadership turnover and create recommendations for best practices. Ultimately, the results from this study are intended to increase stability at HBCUs experiencing leadership transitions so HBCUs can continue to play their important role in broadening participation in STEM, undertaking important STEM research, and providing excellent STEM educational programs. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15738", "attributes": { "award_id": "1R21AI183025-01A1", "title": "Endoplasmic Reticulum (ER)-phagy in Influenza Infection", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 32597, "first_name": "BROOKE ALLISON", "last_name": "BOZICK", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-12", "end_date": "2027-07-31", "award_amount": 433423, "principal_investigator": { "id": 2476, "first_name": "Vikas", "last_name": "Anathy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2609, "ror": "", "name": "UNIVERSITY OF VERMONT & ST AGRIC COLLEGE", "address": "", "city": "", "state": "VT", "zip": "", "country": "United States", "approved": true }, "abstract": "Influenza infection in susceptible patients results in a higher viral load, cytokine storm, tissue damage, lung function decline, and mortality. It is well known that interferons control influenza burden and inflammatory responses. However, mechanistic understandings of IFN-mediated regulation of influenza burden in the lung epithelial cells is unclear. We have identified a novel association between Endoplasmic Reticulum (ER)-specific-autophagy response, termed ER- phagy, as regulators of the influenza burden in lung epithelial cells. Characterizing the epithelial ER-Phagy-IFN axis in influenza infection will be the focus of the current application. Unraveling this axis in lung epithelial cells provides much-needed mechanistic insights into controlling viral burden and mitigating virus-induced lung injury. Our preliminary data suggest that levels of ER- phagy receptors in lung epithelial cells regulate viral burden in an IFNβ dependent manner. Based on these novel data, we hypothesize that lung epithelial cells upregulate IFNβ- and IRE1- dependent ER-phagy to diminish viral burden. We will test this hypothesis in the following specific aims: In specific aim 1, we will determine that specific ER-phagy receptors are required to decrease influenza burden in epithelial cells and subsequent lung injury. Aim 2 will use epithelial-specific knockouts of IFNAR1 receptor and recombinant interferons to determine that the type-I IFNs regulate ER-phagy activity post-IAV infection to control IAV burden and lung injury. These studies will determine that the ER-Phagy-IFN axis acts as a first line of defense in the primary site of influenza infection (epithelial cells) to decrease the IAV burden and subsequent lung injury.", "keywords": [ "Ablation", "Affect", "Architecture", "Autophagocytosis", "Autophagosome", "Cell Physiology", "Cells", "Data", "Endoplasmic Reticulum", "Epithelial Cells", "Epithelium", "Functional disorder", "Future", "Human", "Infection", "Inflammatory Response", "Influenza", "Influenza A virus", "Injury", "Interferon-α", "Interferons", "Knock-out", "Link", "Literature", "Lung", "Lysosomes", "Measures", "Mediating", "Monitor", "Mus", "Organelles", "Pathway interactions", "Patients", "Phagosomes", "Predisposition", "Process", "Proteome", "Recombinant Interferon", "Regulation", "Respiratory Failure", "Role", "Site", "Stimulus", "Stress", "Testing", "Tissues", "Upregulation", "Viral", "Viral Load result", "Viral Proteins", "Virus", "Virus Diseases", "airway epithelium", "cell type", "cytokine release syndrome", "epithelial injury", "flu", "influenza infection", "insight", "interferon alpha receptor", "lung injury", "mortality", "novel", "patient population", "pulmonary function decline", "receptor", "response", "smooth endoplasmic reticulum membrane" ], "approved": true } } ], "meta": { "pagination": { "page": 1404, "pages": 1424, "count": 14236 } } }