Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1404&sort=-title
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-title", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-title", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=-title", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1403&sort=-title" }, "data": [ { "type": "Grant", "id": "11537", "attributes": { "award_id": "5R43AI167095-02", "title": "A biophysical assay targeting SARS CoV-2 RNA", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 26420, "first_name": "MARY KATHERINE", "last_name": "Bradford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-06-27", "end_date": "2024-05-31", "award_amount": 298689, "principal_investigator": { "id": 25502, "first_name": "sandra Paige", "last_name": "story", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1669, "ror": "", "name": "NUBAD, LLC", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The world is immersed in a health crisis rivaled only by the Spanish flu pandemic of 1918-1919. The difference between the crisis of today and the crisis a century ago is that we have advanced communication technology greatly so that huge populations of people around the globe are aware of risks and can take appropriate precautions, such as the employment of quarantining, isolation, social distancing, and masks and handwashing. Governments have closed schools and outlawed large social gatherings. Medical care has greatly improved, and those most affected have received symptomatic treatment in the absence of a cure for CoVID-19. The problem must be dealt at multiple fronts, such as vaccine development, drug development and new technologies, assays for mitigating viral effects. The proposed project is significant because it proposes a novel in vitro biophysical screening assay for a unique and yet untapped RNA structure in SARS-CoV-2 virus, that can be used in the future to generate RNA specific antiviral compounds. Nucleic acids are promising avenues for drug design, both as therapeutics and as targets. Here we propose an innovative screening approach for identification of a novel class of ligands that are specific for an RNA element within the viral RNA genome that is vital for replication of the virus, and we propose a biophysical screening assay as a first step for identifying such ligands. First, as outlined in Specific Aim 1, we will characterize a model nucleic acid (RNA) domain that will be synthesized, characterized and used to identify a RNA specific fluorescent probe. The optimized probe will then be used for developing a high-throughput screening assay for discovery of nanomolar binders to this RNA. The RNA specific high-affinity binders will then be combined with sequence-specific RNA binding ligands to validate the assay development and its utility. The mechanism of action will be confirmed using inhibition of firefly luciferase translation in a reporter gene assay (Specific Aim 2). While the focus of this application, as the needed first step, is on the development and validation of the biophysical assay for the underlying SARS-CoV-2 RNA structures, a successful validation of the approach will open the doors for discovery and development of lead compounds for inhibition of SARS-CoV in Phase II studies. NUBAD and its team of scientists and collaborators is uniquely qualified to perform these assays and develop the potential leads in Phase II, in addition to providing a template for the scientific community to use the screening technology for their own discovery platforms. Success of the approach will also allow us to expand the screening technology to other RNA structures in SARS and other RNA viruses, and provide the screening resource as a service to the scientific community.", "keywords": [ "1918 influenza pandemic", "2019-nCoV", "5&apos", "Untranslated Regions", "Address", "Affect", "Affinity", "Amino Sugars", "Antisense Oligonucleotides", "Antiviral Agents", "Awareness", "Bacterial Genes", "Binding", "Biological Assay", "Biophysics", "COVID-19", "COVID-19 pandemic", "COVID-19 treatment", "Caring", "Cell Culture Techniques", "Cessation of life", "Chemicals", "Chemistry", "Communication", "Communities", "Complex", "Coughing", "Country", "Development", "Disease", "Drug Design", "Elements", "Employment", "Event", "Exposure to", "Firefly Luciferases", "Fluorescence", "Fluorescent Probes", "Future", "Genes", "Genetic Transcription", "Genome", "Government", "Grant", "Handwashing", "Health", "Health Status", "Healthcare Systems", "High Pressure Liquid Chromatography", "Human", "In Vitro", "Individual", "Infection", "Infection prevention", "Interruption", "Laboratories", "Lead", "Legal patent", "Libraries", "Life", "Ligand Binding", "Ligands", "Masks", "Medical", "Mental Health", "Messenger RNA", "Modeling", "National Institute of Allergy and Infectious Disease", "Nucleic Acids", "Persons", "Phase", "Population", "Proteins", "Proteome", "Public Health", "Qualifying", "Quarantine", "RNA", "RNA Binding", "RNA Sequences", "RNA Viruses", "RNA library", "RNA replication", "Rapid screening", "Reporter Genes", "Resources", "Respiratory distress", "Reverse Transcription", "Ribonucleic Acid Regulatory Sequences", "Risk", "Role", "SARS coronavirus", "SARS-CoV-2 infection", "Scientist", "Services", "Severe Acute Respiratory Syndrome", "Small Business Innovation Research Grant", "Small Business Technology Transfer Research", "Social Distance", "Solid", "Structure", "Technology", "Tennessee", "Therapeutic", "Transactivation", "Transcript", "Translations", "Universities", "Untranslated Regions", "Vaccination", "Vaccines", "Validation", "Viral", "Viral Proteins", "Virus", "Virus Replication", "Work", "analog", "assay development", "biophysical analysis", "chemical synthesis", "combat", "design", "drug development", "experimental study", "genomic RNA", "high throughput screening", "improved", "innovation", "interest", "microbial", "mutant", "nanomolar", "new technology", "novel", "pandemic coronavirus", "pandemic disease", "phase 2 study", "phosphorodiamidate morpholino oligomer", "physical conditioning", "prevent", "respiratory", "school closure", "screening", "social", "stem", "success", "symptom managem" ], "approved": true } }, { "type": "Grant", "id": "15932", "attributes": { "award_id": "3U24DK112340-08S1", "title": "A biochemical roadmap of exercise signal", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 44377, "first_name": "PADMA", "last_name": "MARUVADA", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2027-05-31", "award_amount": 500000, "principal_investigator": { "id": 44378, "first_name": "Clary B", "last_name": "Clish", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 24074, "first_name": "ROBERT E", "last_name": "GERSZTEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 771, "ror": "https://ror.org/04drvxt59", "name": "Beth Israel Deaconess Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 1003, "ror": "", "name": "BROAD INSTITUTE, INC.", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Exercise is an effective intervention for both the prevention and treatment of cardiometabolic diseases, but the mechanistic underpinnings of the health benefits of exercise remain incompletely defined. Recent work highlights the importance of inter-organ circuits in mediating healthful exercise responses. We identified β- aminoisobutyric acid (BAIBA) as a novel small molecule “myokine” that increases the expression of brown adipocyte-specific genes in vitro and improves glucose disposal and decreases weight gain in mice. In humans, plasma BAIBA concentrations are increased with chronic exercise and demonstrate a strong inverse association with metabolic risk factors. Further, related efforts by our group have positioned us as leaders in characterizing within- and between-tissue molecular responses to exercise and dietary interventions. These experiences, coupled with the high translational relevance of the research problem, motivated our participation in the MoTrPAC initiative. Our team was built upon existing collaborations between Duke, Harvard and the Broad Institute with complementary strengths in metabolomics and proteomics technologies and decades of experience in cardiometabolic research. To date, we have provided a deep menu of analytical tools for targeted and non-targeted metabolomics, protein profiling, and the analysis of key protein post-translational modifications. Group members have been deeply involved in the animal and pre-COVID biochemical profiling efforts, in collaborations with other Chemical Analysis Sites (CAS) and the Bioinformatics Core to harmonize workflows, and in the working groups necessary to integrate the data. We have also played key roles in associated scholarly activities and in developing the next generation of translational investigators focused on exercise science. An additional distinction of our team is the ability to integrate new findings from MoTrPAC with ongoing genomic, proteomic and metabolomic analyses in large human cohorts and other exercise studies led by our investigators. We hypothesize that integrating the metabolomic and proteomic profiles of human tissues and blood during exercise with genetics and detailed human phenotyping will provide novel insights into the interorgan circuits and within-organ responses that mediate its salutary effects. We are deeply committed to the notion that all data generated by this multi-disciplinary consortium will be made rapidly available to the scientific community.", "keywords": [ "Adipocytes", "Aminoisobutyric Acids", "Animals", "Biochemical", "Bioinformatics core", "Blood", "COVID-19", "Cardiometabolic Disease", "Chemicals", "Chronic", "Collaborations", "Communities", "Coupled", "Data", "Dietary Intervention", "Exercise", "Genes", "Genetic", "Genomics", "Goals", "Health", "Health Benefit", "Heart Diseases", "Human", "In Vitro", "Individual", "Longevity", "Mediating", "Metabolic", "Metabolic Diseases", "Molecular", "Mus", "Organ", "Phenotype", "Plasma", "Play", "Positioning Attribute", "Post-Translational Protein Processing", "Prevention", "Proteomics", "Research", "Research Personnel", "Risk Factors", "Science", "Signal Transduction", "Site", "Technology", "Therapeutic Intervention", "Tissues", "Weight Gain", "Work", "analytical tool", "cardiometabolism", "cohort", "data integration", "effective intervention", "exercise intervention", "experience", "glucose disposal", "human tissue", "improved", "insight", "member", "metabolomics", "multidisciplinary", "next generation", "novel", "novel therapeutics", "protein profiling", "response", "small molecule", "translational scientist", "working group" ], "approved": true } }, { "type": "Grant", "id": "4587", "attributes": { "award_id": "1359595", "title": "A Bioarchaeological Reconstruction of Demography and Social Class", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "Archaeology" ], "program_reference_codes": [], "program_officials": [ { "id": 15838, "first_name": "John", "last_name": "Yellen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2014-06-01", "end_date": "2020-09-30", "award_amount": 207772, "principal_investigator": { "id": 15839, "first_name": "Bethany", "last_name": "Turner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 300, "ror": "", "name": "Georgia State University Research Foundation, Inc.", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 300, "ror": "", "name": "Georgia State University Research Foundation, Inc.", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The fundamental goal of this research is to gain insight into how large political entities such as empires and state level societies integrate large numbers of individuals, often speaking different languages and of different ethnicities into centralized functioning units and the effect that such integration has on different groups of individuals. Through use of archaeological data it is possible both to trace such processes over time and to examine aspects of human biology which might be difficult to accomplish with living populations.\n\nWith support from the National Science Foundation, Dr. Bethany Turner will conduct a three-year project analyzing archaeological human remains from the southern highlands of Peru. In collaboration with her Peruvian colleagues and their students, as well as her own students, Dr. Turner will reconstruct patterns of diet and migration in over two hundred individuals recovered from three sites in the heartland of the Inca Empire. In just under a century, the Inca took control of large areas of western South America and subjugated an estimated twelve million people. As part of their governing strategies, Inca administrators forcibly relocated individuals and even entire communities throughout the empire - this strategy quashed pockets of resistance, relocated communities of specialists to where their skills were most needed, and provided an enormous labor pool for military campaigns and building projects. It also translated to different patterns of diet, disease exposure, violence, and other key factors influencing the health and well-being of Inca subjects. Reconstructing the composition of populations at different Inca sites is therefore critical to better understanding whether, and if so, how the life histories of different Inca subjects were affected by Inca imperialism: estimating who was moved, from where, to where, and why can provide insights into not only their life histories, but those of in situ populations by comparison.\n\nTo accomplish this goal, Turner and her colleagues will produce a combination of multi-isotopic data from collected samples of bone and tooth fragments from each individual, as well as dental data that represent aspects of genetic ancestry. These data will be used to create in-depth profiles of diet and residence at different points in the lifespan and relate them to genetic variation within and between each site. Moreover, these data will be analyzed along with published and unpublished data on skeletal health and disease, using Turner's novel approach to better understanding the causes of common skeletal pathological conditions.\n\nThe intellectual merit of this study lies in its use of multiple lines of data to reconstruct aspects of identity and life history in a large sample of indigenous remains, and interpret them using a theoretical perspective centered on social stratification, resource inequality, and ancient statecraft. These data also provide new opportunities to tease apart the different causes of stressors affecting the skeleton, an area of longstanding debate in biological anthropology.\n\nThis study has broader impacts for archaeology and historical studies, particularly of complex and urbanized societies. The Inca Empire was like other states, past and present, in that it stood on the shoulders of its people, most of whom passed anonymously into history. This study's focus on analyzing the skeletal remains of Inca subjects opens a new window into understanding the workings of this ancient empire. This study also provides valuable research opportunities for students in the United States and Peru. Importantly, the results of these analyses will be disseminated to academic and non-academic audiences in the United States and Peru, including to those indigenous descendants of the Inca who are often marginalized in modern Peruvian culture.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "9591", "attributes": { "award_id": "2217953", "title": "A Bioarchaeological Investigation of Mobility and Infectious Disease", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "Biological Anthropology" ], "program_reference_codes": [], "program_officials": [ { "id": 3025, "first_name": "Rebecca", "last_name": "Ferrell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-15", "end_date": "2025-07-31", "award_amount": 415000, "principal_investigator": { "id": 9422, "first_name": "Jane", "last_name": "Buikstra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25348, "first_name": "Anne C", "last_name": "Stone", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 25349, "first_name": "Kelly J", "last_name": "Knudson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 25350, "first_name": "Allisen C", "last_name": "Dahlstedt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 25351, "first_name": "Kelly E", "last_name": "Blevins", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 147, "ror": "https://ror.org/03efmqc40", "name": "Arizona State University", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "Tuberculosis is second only to COVID-19 as a worldwide cause of death by a single pathogen. Its history reflects extraordinary resiliency, which involves a remarkable number of nonhuman hosts in its global spread. This project, which uses molecular and biogeochemical methods, extends knowledge of the history and spread of tuberculosis in relationship to human mobility across ancient communities from a diverse landscape. Studying humankind’s past experience with epidemic disease over time encourages attention to the factors responsible for disease spread and importance of viewing disease in the broadest possible landscape—one that includes the environment and all microbes and potential hosts. This study reaches the public through active websites, presentations, publicly available YouTube videos in both English and Spanish, as well as in-person presentations. The project fosters international research collaborations and provides research experiences for undergraduate and graduate students and professionals in molecular techniques, biogeochemical analyses, and data analysis that will help them be competitive in the job market. \n\nThis study explores the spread of a form of tuberculosis that severely affected communities throughout the Americas long before European contact. In so doing, it considers intersecting identities and mobility patterns, along with human interactions with other species (pinnipeds, bacteria) in contrastive environmental settings. The database reflects a comprehensive survey of a region with extensive evidence of ancient tuberculosis. By combining molecular and skeletal evidence with biogeochemical indicators of paleomobility, this research can characterize the complex cycles of tuberculosis introduction and spread from a pinniped source along the coast to inland communities where it apparently became a human disease. The study considers the complex routes by which tuberculosis can spread across communities. Hypotheses specifically address expected outcomes of ongoing introductions from sea mammals and humans as novel primary hosts and disease spreaders. An important part of this project is to characterize the mobility and interaction patterns of individuals and communities that present evidence of Mycobacterium tuberculosis complex diseases. Such evidence is crucial to developing nuanced models for disease spread across time and space. The data generated and results are to be published in peer-reviewed articles and formats accessible to the public.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15927", "attributes": { "award_id": "1U01DA063078-01", "title": "A binational cohort of the intersection between substance use, HIV, and associated comorbidities among people who inject drugs in San Diego, CA", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 44370, "first_name": "SHEBA KING", "last_name": "DUNSTON", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-07-15", "end_date": "2030-05-31", "award_amount": 2437310, "principal_investigator": { "id": 23320, "first_name": "STEFFANIE A.", "last_name": "STRATHDEE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 760, "ror": "https://ror.org/0168r3w48", "name": "University of California, San Diego", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 44371, "first_name": "Britt", "last_name": "Skaathun", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2637, "ror": "", "name": "UNIVERSITY OF CALIFORNIA, SAN DIEGO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "We will prospectively study the intersection between substance use, HIV and related co-morbidities in a cohort of people who use drugs (PWUD) in San Diego County (SD). For >25 years, Strathdee has studied the epidemiology of HIV and related co-infections among PWUD across North America, with N=500-1000 and annual retention ≥90%. Since 2020, our La Frontera I cohort situated on the U.S.-Mexico border has documented the highest HIV and HCV incidence among people who inject drugs in North America. Currently, HIV prevalence among former injectors in SD is 16% compared to 10% among current injectors. Consistent with other U.S. cities, we observed a dramatic shift from injection to non-injection of opiates in recent years, leading us to propose cohort expansion to non-injectors. Due to our location on a major drug trafficking corridor, we observe a wide range of substances (e.g., heroin, fentanyl, methamphetamine, xylazine, benzodiazepines). We previously leveraged La Frontera I to evaluate initiatives to improve uptake of PrEP, COVID-19 testing and vaccination. We propose: 1) To characterize trends and predictors of use of established and emerging drugs, drug use transitions (e.g., shifts from IDU to non-IDU & vice versa) and their impact on HIV incidence and utilization of HIV prevention and treatment. 2) To study prevalence and incidence of the following co-morbidities and their relationship to HIV incidence and utilization of HIV prevention and treatment: i) HCV; ii) STIs (i.e., syphilis, gonorrhea, Chlamydia, MPox), iii) neurobehavioral disturbances. 3) To evaluate the influence of structural interventions on HIV-related risk behaviors and utilization of HIV prevention and treatment including: i) new homelessness policies; ii) drug checking services; iii) vending machines. 4) To contribute to a shared database and biorepositories that serve as a platform for collaborations with end users and community partners. To meet these aims, we will continue to follow PWUD from La Frontera I who are actively using illicit substances, replenishing to arrive at 500 PWID and 500 PWUD (non-injectors) for a total sample of 1000. This will include subgroups vulnerable to HIV in SD (e.g., sex workers, people experiencing homelessness) among whom we expect 52 HIV seroconversions after 5 years of follow-up. Our cohort will include at least 50 PWUD living with HIV who will provide samples for viral load, sequencing and biobanking. All participants will undergo semi-annual interviews and specimen collection. SD is designated as a high priority jurisdiction for the Ending the HIV Epidemic Initiative (EHE) and a high intensity drug trafficking area by the DEA. La Frontera II leverages NIH-funded T32s, the California NeuroHIV Tissue Network, Last Gift Study brain/tissue repositories and the PREPARE Institute which tracks emerging and re-emerging infectious disease threats. Our work is aligned with priorities identified by RFA-DA-25-003, the NIH Office of AIDS Research and the EHE.", "keywords": [ "AIDS prevention", "Area", "Benzodiazepines", "Biological", "Border Crossings", "Brain", "COVID-19", "COVID-19 testing", "COVID-19 vaccination", "California", "Chlamydia", "Cities", "Collaborations", "County", "Coupled", "Drug usage", "Drug user", "Emerging Communicable Diseases", "Environmental Exposure", "Epidemic", "Epidemiology", "Fentanyl", "Functional disorder", "Funding", "Gifts", "Goals", "Gonorrhea", "HIV", "HIV Seropositivity", "HIV risk", "HIV/HCV", "Harm Reduction", "Health", "Hepatitis C Incidence", "Hepatitis C virus", "Heroin", "Homelessness", "Incidence", "Infectious disease threat", "Injecting drug user", "Injections", "Intervention", "Interview", "Lived experience", "Location", "Meta-Analysis", "Methamphetamine", "Mexico", "Modeling", "Molecular Epidemiology", "Monkeypox", "Mood Disorders", "NIH Office of AIDS Research", "National Institute of Drug Abuse", "Needle Sharing", "Neurocognitive", "North America", "Opioid", "Participant", "Pattern", "Persons", "Pharmaceutical Preparations", "Policies", "Positioning Attribute", "Postdoctoral Fellow", "Prevalence", "Prevalence Study", "Prospective Studies", "Prospective cohort", "Prospective cohort study", "Research", "Research Priority", "Risk Behaviors", "Sample Size", "Sampling", "Services", "Statutes and Laws", "Subgroup", "Syphilis", "Testing", "Tissue Banks", "Tissues", "Travel", "United States National Institutes of Health", "Viral Load result", "Visit", "Work", "Xylazine", "biobank", "co-infection", "cohort", "community partners", "comorbidity", "data sharing", "end of life", "epidemiology study", "experience", "fentanyl use", "follow-up", "housing instability", "improved", "member", "neuroAIDS", "neurobehavioral", "novel", "pre-doctoral", "pre-exposure prophylaxis", "prevention service", "recruit", "repository", "response", "retention rate", "sample collection", "seroconversion", "severe mental illness", "sex", "shared database", "sociodemographics", "substance use", "syndemic", "synthetic drug", "systematic review", "trafficking", "transmission process", "treatment services", "trend", "uptake" ], "approved": true } }, { "type": "Grant", "id": "10514", "attributes": { "award_id": "1G20AI174728-01", "title": "A Bedside-to-Bench Approach to Pandemic Preparedness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 24445, "first_name": "Nancy G.", "last_name": "Boyd", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-16", "end_date": "2024-02-29", "award_amount": 3906967, "principal_investigator": { "id": 26522, "first_name": "KENNETH W.", "last_name": "BAYLES", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 628, "ror": "https://ror.org/00thqtb16", "name": "University of Nebraska Medical Center", "address": "", "city": "", "state": "NE", "zip": "", "country": "United States", "approved": true }, "abstract": "The clinical capabilities of the University of Nebraska Medical Center (UNMC) and its clinical partner, Nebraska Medicine (NM), played vital roles in the treatment of U.S. citizens infected with Ebola in 2014 and the early response to the COVID-19 pandemic. While the presence of the National Quarantine Unit (NQU) and the Nebraska Biocontainment Unit (NBU) on campus provided UNMC researchers with some of the earliest access to individuals exposed to infectious agents (in the NQU), as well as those who begin to develop disease (in the NBU), we recognized a key gap in our capabilities is the lack of modern technologies within our high- containment spaces required to gain greater insights into the pathogenic mechanisms utilized by new and emerging pathogens. Therefore, the overall goal of this proposed project is to modernize our high-containment research laboratories to maximize their research potential and to leverage our clinical expertise to foster research on vaccine and therapeutic development. This will be achieved in two ways: First, we will improve our biocontainment infrastructure within key biocontainment research facilities in a way that increases our capacity to conduct research on high-consequence pathogens, maximizes synergy between the various biocontainment laboratories, and increases biosecurity. Second, we will invest in the modern technologies needed in our BSL-3 and ABSL-3 laboratories to conduct cutting-edge studies on new and emerging pathogens and to address critical questions related to disease pathogenesis. Upon completion, these improvements will foster much greater synergy between the clinical and research arms of UNMC and NM, leveraging early access to clinical data/samples to streamline research into disease pathogenesis, and to accelerate the development of new vaccines and therapeutics during future pandemics.", "keywords": [ "Address", "Animal Model", "COVID-19 pandemic", "Cell Separation", "Cell physiology", "Clinical", "Clinical Data", "Clinical Research", "Communicable Diseases", "Containment", "Decontamination", "Development", "Diagnostic", "Disease", "Ebola", "Enhancement Technology", "Environment", "Equipment", "Event", "Exposure to", "Faculty", "Fostering", "Future", "Goals", "Human Resources", "Individual", "Infection", "Infectious Agent", "Infectious Diseases Research", "Infrastructure", "Investments", "Laboratories", "Laboratory Research", "Medical center", "Medicine", "Microscopy", "Modernization", "Nebraska", "Pathogenesis", "Pathogenicity", "Patients", "Play", "Quarantine", "Research", "Research Personnel", "Role", "Sampling", "Standardization", "Technology", "Universities", "Update", "Work", "arm", "bench to bedside", "biocontainment facility", "biosecurity", "diagnostic assay", "emerging pathogen", "high efficiency particulate air filter", "improved", "insight", "interoperability", "laboratory development", "novel diagnostics", "novel therapeutics", "novel vaccines", "pandemic disease", "pandemic preparedness", "pathogen", "recruit", "research facility", "response", "synergism", "therapeutic development", "vaccine development" ], "approved": true } }, { "type": "Grant", "id": "5504", "attributes": { "award_id": "3U54AI142766-04S1", "title": "A 3D Tissue Map of the Human Lymphatic System", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 19154, "first_name": "Kentner L.", "last_name": "Singleton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-08", "end_date": "2022-06-30", "award_amount": 433718, "principal_investigator": { "id": 19155, "first_name": "MARK A.", "last_name": "ATKINSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 19156, "first_name": "Bernd", "last_name": "Bodenmiller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 19157, "first_name": "HARRY S", "last_name": "NICK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The lymphatic system serves five primary roles: 1) removal of excess body fluids; 2) absorption and transport of fatty acids/chyle to the circulatory system; 3) blood filtration; 4) mounting the primary defense against infections and cancer through immune cell production and activation; and 5) generation and activation of regulatory immune cells that protect against autoimmune/autoinflammatory disease. Given these key physiological functions, we deem it important to develop a three-dimensional (3D) tissue map for three major lymphoid organs of the human immune system: spleen, thymus and lymph nodes (Organ Specific Projects 1- 3, respectively). As one of our primary strengths, we have over 10 years of experience in the procurement of transplant-quality organs for research, including those of the lymphatic system. As part of this 24/7/365 effort, we have well-established relationships with the U.S. Organ Procurement Organizations (OPO), having referrals from 56/58 over the last decade. Our standard operating procedures (SOPs), both published and web-based, include assessment of normality, quality control assays, and systematic anatomical dissection/storage. We also participate in National QA/QC programs to evaluate tissue processing/banking procedures. Our approach to developing assay pipelines towards the common goal of a 3D tissue map will initially involve acquiring a macro image of the intact tissue and addressing tissue morphology, using our strengths in magnetic resonance imaging (MRI). The proposed optical microscopy pipeline will address microanatomical features using formalin fixed paraffin embedded (FFPE) and optimal cutting temperature (OCT) compound embedded sections as well as tissue optical clearing and expansion. These specimens will be studied from nm to mm resolution using stochastic optical reconstruction microscopy (STORM), confocal, multiphoton and light sheet fluorescence microscopies (LSFM), with all pipelines sharing a common file format for simplified 3D reconstruction. Based on the unique role for lymphatic organs in production and trafficking of immune cells, fluorescence activated cell sorting (FACS) of cells from blood and each lymphatic organ will provide a comparison of the patient- specific immune cell repertoire and serve in subsequent single cell RNA-seq analyses. To co-register biomolecules to their cognate cells, we will employ imaging mass cytometry (IMC), multiplex single molecule fluorescence in situ hybridization (smFISH) and multiplexed error-robust FISH (MERFISH) to map cellular protein and mRNA expression, ultimately on each 3D tissue atlas. Our experience in organ procurement, the availability of the National High Magnetic Field Laboratory (NHML) Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility at UF, multiphoton/confocal microscopy, LSFM, state of the art FACS, 10X GENOMICS Chromium controller, and high throughput cDNA library sequencing for RNA-Seq at the University of Florida, as well as world leading IMC and 3D data analysis facility at the University of Zurich, ideally positions us to provide the highest quality 3D Human BioMolecular Atlas (HuBMAP) of the lymphatic organs.", "keywords": [ "3-Dimensional", "Address", "Advisory Committees", "Aging", "Algorithms", "Anatomy", "Antigen-Presenting Cells", "Architecture", "Atlases", "Autoimmune", "B-Lymphocytes", "Back", "Biological Assay", "Blood", "Blood Circulation", "Body Fluids", "Body fat", "Cardiovascular system", "Cell Separation", "Cells", "Chromium", "Chyle", "Clinical Data", "Collaborations", "Communities", "Confocal Microscopy", "Consultations", "Coupled", "Cytometry", "Data", "Data Analyses", "Data Files", "Dendritic Cells", "Diabetes Mellitus", "Discontinuous Capillary", "Disease", "Dissection", "Drainage procedure", "Erythrocytes", "Excision", "Exclusion Criteria", "Florida", "Flow Cytometry", "Fluorescence Microscopy", "Fluorescence-Activated Cell Sorting", "Fluorescent in Situ Hybridization", "Formalin", "Fostering", "Generations", "Goals", "Housing", "Human", "Human BioMolecular Atlas Program", "Human body", "IgG2", "Image", "Immune", "Immune response", "Immune system", "Immunity", "Immunoglobulin M", "Immunohistochemistry", "Immunologic Surveillance", "In Situ Hybridization", "Infection", "Invaded", "Knowledge", "Laboratories", "Leukocytes", "Life", "Light", "Link", "Lobular", "Longevity", "Lymph", "Lymphatic System", "Lymphatic function", "Lymphocyte", "Magnetic Resonance Imaging", "Malignant Neoplasms", "Malpighian corpuscles", "Maps", "Messenger RNA", "Microscopy", "Morphology", "Normalcy", "Online Systems", "Optics", "Organ", "Organ Donor", "Organ Procurements", "Organism", "Pancreas", "Paraffin Embedding", "Pathologist", "Patients", "Periarteriolar Lymphoid Sheath", "Peripheral", "Physiological", "Positioning Attribute", "Pregnancy", "Procedures", "Production", "Proliferating", "Protocols documentation", "Publishing", "Quality Control", "Recording of previous events", "Reproducibility", "Research", "Research Personnel", "Resolution", "Reticular Cell", "Rodent", "Role", "Series", "Site", "Specimen", "Spleen", "Splenic Red Pulp", "Stains", "Stretching", "Structure", "Structure of germinal center of lymph node", "Structure of thymic cortex", "System", "T-Cell Development", "T-Lymphocyte", "Temperature", "Thymus Gland", "Tissues", "Transplantation", "United States National Institutes of Health", "Universities", "Vascular blood supply", "Veins", "Visualization", "Work", "absorption", "arteriole", "autoinflammatory", "base", "blood filter", "blood filtration", "cDNA Library", "cancer cell", "data sharing", "daughter cell" ], "approved": true } }, { "type": "Grant", "id": "6588", "attributes": { "award_id": "3R01AA026289-05S1", "title": ": Complex systems analysis of the impact of alcohol on bone in non-human primates", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 22078, "first_name": "Andras", "last_name": "Orosz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-09-20", "end_date": "2023-05-31", "award_amount": 72235, "principal_investigator": { "id": 22079, "first_name": "URSZULA T", "last_name": "IWANIEC", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 154, "ror": "https://ror.org/00ysfqy60", "name": "Oregon State University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "Understanding the impact of alcohol consumption on bone health is important because alcohol influences bone metabolism and over half of the adult population in the United States drinks alcoholic beverages. Low to moderate levels of alcohol consumption are generally associated with beneficial skeletal effects while chronic alcohol abuse predisposes individuals to bone fractures. The long-term goal of our research is to delineate the primary mechanisms mediating the divergent skeletal effects of low/moderate and heavy alcohol consumption. An appreciation of the precise effects and mechanisms of action of alcohol on bone metabolism is important because of the enormous economic, social and personal burden associated with poor bone health. Progress in understanding the actions of alcohol on bone metabolism are hampered by (1) the extreme difficulty in performing intervention studies in humans, (2) limitations of commonly used animal models, (3) failure to adequately consider alcohol’s effects on tissue and organ systems that impact bone, and (4) difficulty in accurately replicating human drinking behavior in animals. The studies proposed in this R01 application will overcome limitations of human and prior animal studies by using a non-human primate (monkey) model for voluntary alcohol consumption that mimics the full range of human drinking behavior. We will use linear regression models, multivariate linear regression models, machine learning, and systems analysis to establish the impact of pattern of alcohol consumption (none, light/moderate, binge, heavy and very heavy) on bone metabolism in rhesus (Macaca mulatta; n=105) and cynomolgus (Macaca fascicularis; n=86) macaques in the context of sex, age and alcohol-induced perturbations in tissue and organ systems that can influence bone. We will identify the latter perturbations by determining the effect of alcohol on specific protein (e.g., peptide hormones and cytokines) and small molecule (e.g., steroid hormones) effectors in blood. Our central hypothesis, based in part on our preliminary data in rats, macaques and humans, is that changes in the blood levels of bone-active hormones and cytokines, derived from several tissues/organs, in response to alcohol intake act in concert to modulate bone cell number and activity. To test our hypothesis, we propose the following two Specific Aims: Specific Aim 1: Define the correlative relationships between the quantity and pattern of alcohol consumption and bone in male and female macaques. Specific Aim 2: Define the correlative relationships among blood ethanol levels, key bone active hormones and cytokines, and biochemical markers of bone turnover in male and female macaques. At the completion of this project, we expect to have established that the magnitude of skeletal response to alcohol will correlate with changes in serum biochemical markers of bone turnover which, in turn, will correlate with changes in circulating levels of specific hormones and cytokines. The primary positive impact of our anticipated findings is identification of key underlying factors responsible for the complex, context-dependent actions of alcohol on bone metabolism.", "keywords": [ "Adult", "Affect", "Age", "Age of Onset", "Alcohol abuse", "Alcohol consumption", "Alcoholic Beverages", "Alcohols", "Animal Model", "Animals", "Biochemical Markers", "Blood", "Bone Density", "Cell Count", "Cells", "Chronic", "Complex", "Data", "Diet", "Economics", "Energy Intake", "Ethanol", "Failure", "Female", "Fracture", "Goals", "Grant", "Health", "Hormones", "Human", "Individual", "Intake", "Intervention Studies", "Intrinsic factor", "Lead", "Light", "Linear Regressions", "Macaca", "Macaca fascicularis", "Macaca mulatta", "Machine Learning", "Mediating", "Metabolic dysfunction", "Modeling", "Molecular", "Monkeys", "National Institute on Alcohol Abuse and Alcoholism", "Oregon", "Organ", "Outcome", "Pathology", "Pattern", "Physiological", "Population", "Primates", "Proteins", "Rattus", "Research", "Research Project Grants", "Rhesus", "Risk Factors", "Serum", "Site", "Skeleton", "Specimen", "Strategic Planning", "System", "Systems Analysis", "Testing", "Tissues", "Transcend", "United States", "Variant", "alcohol effect", "alcohol measurement", "alcohol research", "alcohol response", "base", "body system", "bone", "bone cell", "bone health", "bone mass", "bone metabolism", "bone turnover", "cytokine", "density", "drinking", "drinking behavior", "drinking onset", "fracture risk", "insight", "male", "multidisciplinary", "nonhuman primate", "nutrient metabolism", "peptide hormone", "sex", "skeletal", "small molecule", "social", "steroid hormone" ], "approved": true } }, { "type": "Grant", "id": "2998", "attributes": { "award_id": "1945322", "title": "9th Workshop on Parallel-in-Time Integration", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "COMPUTATIONAL MATHEMATICS" ], "program_reference_codes": [], "program_officials": [ { "id": 9176, "first_name": "Leland", "last_name": "Jameson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-10-15", "end_date": "2021-09-30", "award_amount": 25185, "principal_investigator": { "id": 9178, "first_name": "Benjamin", "last_name": "Ong", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 512, "ror": "https://ror.org/0036rpn28", "name": "Michigan Technological University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 9177, "first_name": "Jacob B", "last_name": "Schroder", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 512, "ror": "https://ror.org/0036rpn28", "name": "Michigan Technological University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "9th Workshop on Parallel-in-Time Integration\nMichigan Technological University Houghton, Michigan June 8-12,2020.\nhttp://conferences.math.mtu.edu\n\nComputer models and simulations play a central role in the study of complex systems in engineering, life sciences, medicine, chemistry, and physics. Utilizing modern supercomputers to run models and simulations allows for experimentation in virtual laboratories, thus saving both time and resources. Although the next generation of supercomputers will contain an unprecedented number of processors, this will not automatically increase the speed of running simulations. New mathematical algorithms are needed that can fully harness the processing potential of these new systems. Parallel-in-time methods, the subject of this workshop, are timely and necessary, as they extend existing computer models to these next generation machines by adding a new dimension of scalability. Thus, the use of parallel-in-time methods will provide dramatically faster simulations in many important areas, such as biomedical applications (e.g., heart modeling), computational fluid dynamics (e.g., aerodynamics and weather prediction), and machine learning. Computational and applied mathematics plays a foundational role in this projected advancement. \n\nThe primary focus of the parallel-in-time workshop is to disseminate cutting-edge research and facilitate scientific discussions on the field of parallel time integration methods. This workshop aligns with the National Strategic Computing Initiative (NCSI) objective: 'increase coherence between technology for modeling/simulation and data analytics'. The need for parallel time integration is being driven by microprocessor trends, where future speedups for computational simulations will come through using increasing numbers of cores and not through faster clock speeds. Thus as spatial parallelism techniques saturate, parallelization in the time direction offers the best avenue for leveraging next generation supercomputers with billions of processors. Regarding the mathematical treatment of parallel time integrators, one must use advanced methodologies from the theory of partial differential equations in a functional analytic setting, numerical discretization and integration, convergence analyses of iterative methods, and the development and implementation of new parallel algorithms. Thus, the workshop will bring together an interdisciplinary group of experts spanning these areas. NSF support for this conference will be used to engage junior researchers in this important research topic.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14025", "attributes": { "award_id": "2136230", "title": "8th Annual HBCU Climate Education Conference", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "GOLD-GEO Opps LeadersDiversity" ], "program_reference_codes": [], "program_officials": [ { "id": 1400, "first_name": "Brandon", "last_name": "Jones", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-01", "end_date": null, "award_amount": 49500, "principal_investigator": { "id": 30514, "first_name": "Beverly", "last_name": "Wright", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2395, "ror": "", "name": "SOUTHERN CENTER FOR ENVIRONMENTAL JUSTICE INC., DEEP SOUTH CENTE", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The Deep South Center for Environmental Justice will partner with the Barbara Jordan-Mickey Leland School of Public Affairs at Texas Southern University, in collaboration with thirty-two (32) Historically Black Colleges and Universities (HBCUs) and fifteen (15) community-based organizations, to host the 8th Annual HBCU Climate Education Conference in New Orleans, Louisiana on October 6 – 10, 2021. The Conference addresses the significant need for climate education for HBCU students who are largely under-represented in scholarship on climate science, but over-represented as members of communities most vulnerable to climate impacts. Conference sessions will explore the dynamics of racial, social, public health and economic disparities in the wake of climate-related disasters, serving as a call to action for students at HBCUs to become engaged in the conversation around climate impacts and equity.<br/><br/>The aim of the Conference is to bridge the gap between theory and the experiential realities of climate impacts by bringing together HBCU faculty and students, researchers, climate scientists, and environmental justice and coastal community residents impacted by toxic facilities and severe weather events. The major purpose of the Conference is four-fold: (1) introduce HBCU students to climate science; (2) engage students with Gulf Coast communities experiencing climate impacts; (3) engage students in the practice of the profession through the presentation of research findings; and (4) interact with and learn from professional experts in the field. The Conference is a one-of-a-kind national meeting that strives to create synergy between academia and vulnerable communities; contribute to addressing chronic or emerging challenges related to climate impacts in coastal regions and port cities that can be exacerbated by offshore oil and gas operations and natural disasters; and foster the development of leadership and communication skills, competencies in science literacy, and capabilities of participating HBCU students.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1404, "pages": 1424, "count": 14236 } } }