Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1404&sort=-award_amount
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-award_amount", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-award_amount", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=-award_amount", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1403&sort=-award_amount" }, "data": [ { "type": "Grant", "id": "12267", "attributes": { "award_id": "1I01BX006270-01", "title": "SARS-CoV-2 and Innate Immunity: Mechanisms of Resistance to Human Interferons", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2027-09-30", "award_amount": null, "principal_investigator": { "id": 28150, "first_name": "Eric M.", "last_name": "Poeschla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1828, "ror": "https://ror.org/04d7ez939", "name": "VA Eastern Colorado Health Care System", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "12769", "attributes": { "award_id": "1I01BX004686-01A2", "title": "Calcium release-activated calcium (CRAC) channels in experimental traumatic brain injury", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2027-09-30", "award_amount": null, "principal_investigator": { "id": 28673, "first_name": "Midori A", "last_name": "Yenari", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1522, "ror": "", "name": "VETERANS AFFAIRS MED CTR SAN FRANCISCO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will explore calcium-release-activated calcium channels (CRAC) as a potential therapeutic target in a laboratory model of traumatic brain injury (TBI). TBI is a common problem in the Veteran and civilian populations but definitive treatments are few. Microglia are the brain’s resident immune cell, and many studies have now shown that when activated, they contribute negatively to neurological outcome. Thus, strategies to inhibit microglial functions could prove therapeutic. Recent work has focused on the role of CRAC channels in inflammatory cells such as T cells, mast cells and neutrophils, and other inflammatory conditions such as autoimmune disease and acute pancreatitis; however, very little work has been published on CRAC channels as they pertain to microglia or inflammation in the brain. Past work has focused on calcineurin inhibitors such as cyclosporine A and FK 506 which act downstream of the CRAC channel, but have many off target effects and clinical toxicities which limit their use. These CRAC channel inhibitors are already being studied at the clinical level for other indications, and do not appear to have the same toxicities as the CNIs. In fact, a similar inhibitor produced by the same company was recently shown to improve outcome from severe COVID-19 pneumonia following infection with the SARS-CoV-2 virus, and was well tolerated in this patient population. Prior work in our lab showed that these specific CRAC channel inhibitors block microglial activation and that at least one of these inhibitors protects the brain from experimental TBI. This project will study CRAC channel inhibitors in a model of TBI to further define the conditions where neuroprotection may be observed. The first Aim will determine the more protective of two such novel CRAC channel inhibitors, and determine the optimal dosing required for maximum neurological benefit. This aim will also validate the specificity of the inhibitors and the expected mechanism of action of downstream calcium and inflammatory signaling. The second aim will then determine whether treatment can be delayed by hours and still show improvement in neurological outcomes. The third aim will then use the optimal dose and dosing regimen determined from the first two aims to see if any benefit is long lasting. In vivo experiments will include studies in female animals as well as comparing these novel, specific inhibitors to currently available, but less specific inhibitors.", "keywords": [ "2019-nCoV", "Acute", "Acute Brain Injuries", "Affect", "Animals", "Area", "Autoimmune Diseases", "Binding", "Biological Assay", "Biotechnology", "Brain", "Brain Injuries", "COVID-19", "COVID-19 pneumonia", "Calcineurin", "Calcineurin Pathway", "Calcineurin inhibitor", "Calcium", "Calcium Channel", "Cells", "Clinical", "Collaborations", "Cyclosporine", "Cytoprotection", "Dose", "Experimental Models", "FK506", "Female", "Hour", "Human", "Immune", "Immune response", "Immune signaling", "Immunosuppression", "In Vitro", "Infection", "Inflammation", "Inflammatory", "Inflammatory Response", "Injury", "Laboratories", "Length", "Mediating", "Microglia", "Modeling", "Mus", "Nervous System Trauma", "Neurologic", "Neurological outcome", "Outcome", "Pathway interactions", "Plasma", "Population", "Publishing", "Pulmonary Inflammation", "Regimen", "Regulation", "Role", "Signal Transduction", "Site", "Source", "Specificity", "Stroke", "T-Lymphocyte", "Tacrolimus", "Testing", "Therapeutic", "Toxic effect", "Translations", "Traumatic Brain Injury", "Up-Regulation", "Veterans", "Virus", "Woman", "Work", "acute pancreatitis", "brain tissue", "cohort", "effective therapy", "experimental study", "glial activation", "immunoreaction", "improved", "improved outcome", "in vivo", "inhibitor", "knock-down", "male", "mast cell", "men", "neuroprotection", "neutrophil", "novel", "patient population", "prevent", "response", "severe COVID-19", "side effect", "small molecule inhibitor", "stroke model", "therapeutic target" ], "approved": true } }, { "type": "Grant", "id": "12777", "attributes": { "award_id": "1I01CX002502-01A2", "title": "Long-Term Effects of COVID-19 on Cognitive Function and Mental Health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-07-01", "end_date": "2026-06-30", "award_amount": null, "principal_investigator": { "id": 28679, "first_name": "DIANE", "last_name": "SWICK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2157, "ror": "", "name": "VA NORTHERN CALIFORNIA HEALTH CARE SYS", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The ongoing pandemic of COVID-19 continues to have a detrimental impact on society, even after the rapid development of safe and effective vaccines. The worst phases of the pandemic caused systemic and cultural shifts in education, work, commerce, social ties, and even the process of grieving. The SARS-CoV-2 virus has taken 6.5 million lives worldwide, over 1 million lives in the US, and nearly 23,000 Veterans receiving care in the VA system. The highly infectious Omicron variant has caused the largest surge of cases yet, with a peak in mid-January 2022. This variant causes milder symptoms but is more resistant to current vaccines. While the most severely affected COVID patients are rightfully the focus of many investigations, patients with milder disease may show lasting changes as well. An important study by Al-Aly, Xie, and Bowe (2021) identified all non-hospitalized Veterans who had at least one SARS-CoV-2 positive test and who survived 30 days after diagnosis. Six months later, those who had COVID had an excess burden of respiratory conditions, metabolic disorders, cardiovascular conditions, insomnia, fatigue, anxiety disorders, trauma-related disorders, and neurocognitive disorders. Follow-up studies found that many of these conditions can persist for at least one year (Xie et al., 2022a,b). In addition, the risk of adverse health outcomes increases in Veterans with multiple infections (Al-Aly et al., preprint). Although epidemiological studies have been helpful in identifying population-level trends, a key missing perspective can be provided by Veterans’ ratings of their own mental and physical symptoms. This is critical because future interventions require a deeper understanding of the challenges faced by Veterans with post-COVID conditions. The unique needs of Veterans include higher rates of the comorbidities commonly associated with a greater risk of negative COVID outcomes (diabetes, hypertension, and cardiovascular conditions). Ongoing cognitive issues after a COVID infection can also have a negative impact on employment and daily functioning. Cognitive dysfunction was the third most commonly reported symptom in a survey of the Long Covid community (Davis et al., 2021), yet \"brain fog\" remains scantly investigated, especially in Veterans. The proposed observational study will have a two group, prospective, repeated measure (3 time points) design with a study group and a closely matched healthy comparator group. The study group will be Veterans (n=300) who had a positive test for SARS-CoV-2 within the last 3-24 months but were not hospitalized. This population comprises the majority of VA patients with positive tests for SARS-CoV-2 (approximately 85-90%). Their results will be compared to healthy Veteran controls matched on demographic variables, pre-existing psychiatric conditions, and major comorbidities (n=300). Follow-up tests will be conducted six months and 12 months later. The project will obtain objective measures of cognitive performance over time and explore their relationship to mental health (anxiety, depression, PTSD) and other persistent post-acute sequelae of SARS-CoV-2 (PASC) symptoms (insomnia, fatigue) in COVID-19 survivors. Covariates will adjust for baseline scores, number of vaccines, and time since diagnosis. We will also examine the impact of multiple infections on mental health and cognitive outcomes. A validated web-based testing platform will obtain objective and reliable measures of sustained attention, executive function, episodic memory, and working memory. A better understanding of specific weaknesses in cognitive function over time is necessary to identify future intervention targets in the Veteran population with persistent post- COVID conditions. Our study will also establish the importance of monitoring the mental health of Veterans who have recovered from COVID-19. Those with persistent symptoms can be referred to appropriate services to improve their quality of life.", "keywords": [ "2019-nCoV", "Address", "Affect", "Anxiety", "Anxiety Disorders", "COVID diagnosis", "COVID-19", "COVID-19 diagnosis", "COVID-19 impact", "COVID-19 pandemic", "COVID-19 patient", "COVID-19 survivors", "COVID-19 test", "Cardiovascular system", "Caring", "Cognitive", "Commerce", "Communities", "Development", "Diabetes Mellitus", "Diagnosis", "Disease", "Education", "Employment", "Episodic memory", "Fatigue", "Follow-Up Studies", "Future", "Health", "Healthcare Systems", "Heart Diseases", "Hypertension", "Impaired cognition", "Impairment", "Individual", "Infection", "Intervention", "Investigation", "Literature", "Long COVID", "Measures", "Mental Depression", "Mental Health", "Metabolic Diseases", "Minority", "Modeling", "Monitor", "Observational Study", "Occupational", "Online Systems", "Outcome", "Outcome Measure", "Participant", "Patient Self-Report", "Patients", "Performance", "Persons", "Phase", "Population", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Post-Traumatic Stress Disorders", "Printing", "Process", "Psyche structure", "Quality of life", "Recording of previous events", "Reporting", "Resistance", "Risk", "SARS-CoV-2 B.1.1.529", "SARS-CoV-2 positive", "Services", "Short-Term Memory", "Sleep", "Sleeplessness", "Societies", "Surveys", "Survivors", "Symptoms", "System", "Testing", "Time", "Trauma", "Vaccines", "Variant", "Veterans", "Virus", "Work", "associated symptom", "brain fog", "breakthrough infection", "cognitive function", "cognitive performance", "cognitive testing", "comorbidity", "comparison control", "comparison group", "coronavirus disease", "daily functioning", "design", "epidemiology study", "executive function", "follow-up", "improved", "long term consequences of COVID-19", "military veteran", "neurocognitive disorder", "pandemic disease", "persistent symptom", "physical symptom", "post-COVID conditions", "post-COVID-19", "prospective", "respiratory", "selective attention", "social", "social relationships", "sustained attention", "trend", "unvaccinated", "web platform" ], "approved": true } }, { "type": "Grant", "id": "13166", "attributes": { "award_id": "1I01RX004572-01A1", "title": "Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-11-01", "end_date": "2028-10-31", "award_amount": null, "principal_investigator": { "id": 26754, "first_name": "ALICE S.", "last_name": "RYAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 29208, "first_name": "Monica C", "last_name": "Serra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1681, "ror": "https://ror.org/03n2ay196", "name": "South Texas Veterans Health Care System", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Findings of post-acute sequelae of Post-COVID Conditions (PCC) manifestations of fatigue, pain, dyspnea, and muscle weakness, provide a strong rationale for rehabilitation; yet few formal studies exist and the effects of severe acute respiratory syndrome coronavirus-2 infection on function are not well described. Notably, two- thirds of Veterans are overweight and obese, rendering excess adiposity a significant risk factor and a high- priority area related to PCC prevention and care. Obesity increases the risk of severe illness in Veterans recovering from PCC, but how it does so is not fully understood. Recent research suggests that excess adipose tissue is associated with adverse changes in adipose cellular function, and that these variations may be involved in the biology of aging and the etiology of aging- related diseases. Adipose tissue contains cells that have undergone cellular senescence, which induces inflammation, cytotoxicity, and metabolic dysfunction in other cells and tissues. However, the precise role of adipose tissue cellular composition on PCC recovery is limited. Thus, we propose to evaluate the role of obesity and PCC on physical functioning, health-related quality of life (HRQOL), and systemic and adipose tissue inflammatory and cellular senescence profiles in ethnically diverse older Veterans from the Audie Murphy (San Antonio) and Baltimore VA Medical Centers. Further, we propose a randomized controlled trial to determine whether a reduction in body weight and increased physical function by a weight loss intervention (WL), including dietary modification and exercise, in obese Veterans with PCC will reduce systemic and adipose tissue inflammation and senescence, which will have important implications for PCC recovery. We will pursue the following aims: Aim 1: To compare physical function, body composition, HRQOL, PCC symptoms, and adipose tissue molecular profiling in four cohorts of Veterans at baseline: lean PCC naïve, lean with PCC, obese PCC naïve, and obese with PCC (N=150). Aim 2: To compare in Veterans with obesity: a) a 12-week randomized WL vs. weight stability (WS) intervention (30/group) on physical function, body composition, HRQOL, and PCC symptoms together with changes in the global molecular profile in adipose tissue in Veterans with PCC and b) the WL intervention in PCC naïve vs. with PCC (N=30/group) on these outcomes. Older (55-80 years) men and women Veterans will be recruited. We will perform a standard functional battery (maximal aerobic capacity [VO2max; primary outcome], usual gait speed, six min walk distance, timed up and go, and handgrip strength), body composition (dual energy x-ray absorptiometry and computed tomography scans), HRQOL (NIH PROMIS-57), and PCC symptoms (COVID-19 Yorkshire Rehabilitation Scale [C19-YRS]) and adipose tissue will be collected. Further, we will test, in a randomized controlled trial, the hypothesis that a WL intervention, compared to weight stability (WS), improves physical function, body composition, and HRQOL and reduces inflammation and senescent cell burden and to a similar extent as the PCC naïve group with obesity. A deeper understanding of the relationship between adipose tissue and PCC will likely reveal factors that predispose to or protect against aging-related functional declines. Moreover, a better understanding of the effects of a lifestyle intervention on the molecular profile of adipose tissue will help to determine how changes in adipose tissue contribute to PCC and PCC recovery. Lastly, this research will provide important mechanistic insights into how cellular senescence influences the pathophysiology of physical, mental, and social dysfunction in older Veterans. Our findings could provide evidence-based recommendations to promote this type of intervention in Veterans recovering from PCC.", "keywords": [ "2019-nCoV", "Acute", "Adipose tissue", "Aerobic", "Aging", "Area", "Baltimore", "Behavioral", "Biological Assay", "Biology of Aging", "Body Composition", "Body Weight", "COVID-19", "COVID-19 impact", "COVID-19 prevention", "Caring", "Cell Aging", "Cell Cycle Arrest", "Cell physiology", "Cells", "Chronic", "Diet Modification", "Disease", "Dual-Energy X-Ray Absorptiometry", "Dyspnea", "Etiology", "Exercise", "Fatigue", "Fatty acid glycerol esters", "Functional disorder", "Gait speed", "Health", "Individual", "Inflammation", "Inflammatory", "Intervention", "Intramuscular", "Laboratories", "Life Style", "Long COVID", "Medical center", "Metabolic dysfunction", "Molecular Profiling", "Muscle Weakness", "Obesity", "Outcome", "Overweight", "Oxidative Stress", "Pain", "Participant", "Patient Self-Report", "Phenotype", "Physical Function", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Predisposing Factor", "Prevention", "Psyche structure", "Randomized", "Randomized Controlled Trials", "Recovery", "Rehabilitation therapy", "Reporting", "Research", "Risk", "Risk Factors", "Role", "SARS-CoV-2 infection", "Sampling", "Scanning", "Symptoms", "Testing", "Thinness", "Tissue Banks", "Tissues", "United States National Institutes of Health", "VO2max", "Variant", "Veterans", "Visceral fat", "Walking", "Weight", "Woman", "X-Ray Computed Tomography", "clinical implementation", "cohort", "cytotoxicity", "disability", "ethnic diversity", "evidence based guidelines", "functional decline", "health related quality of life", "improved", "innovation", "insight", "lifestyle intervention", "men", "novel", "persistent symptom", "pharmacologic", "physical conditioning", "post-COVID conditions", "post-COVID-19", "primary outcome", "recruit", "response", "senescence", "social deficits", "weight loss intervention" ], "approved": true } }, { "type": "Grant", "id": "13171", "attributes": { "award_id": "1I01CX002616-01", "title": "Genetic predictors, pathophysiological mechanisms, and functional consequences of post-acute sequelae of SARS-CoV-2: Exercise challenge of gut microbiome and neuroinflammation in PASC", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2027-09-30", "award_amount": null, "principal_investigator": { "id": 29215, "first_name": "DANE B.", "last_name": "COOK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2247, "ror": "", "name": "WM S. MIDDLETON MEMORIAL VETERANS HOSP", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "The long-term goals of this research are to determine the mechanisms that underlie Post-Acute Sequelae of SARSCoV-2 (PASC)-related symptoms in Veterans and to develop targeted and personalized treatments. PASC is a condition of long-term symptom burden following coronavirus disease 2019 (COVID-19) that is having serious adverse effects among Veteran populations. Known colloquially as Long-COVID, symptoms of pain, fatigue, irritable bowel, and cognitive impairment overlap considerably with chronic multisymptom illnesses (CMIs) such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI). Critically, all three conditions report that physical activity worsens their illness, a characteristic of CMIs known as post-exertional malaise (PEM). As with CMIs, PEM is a promising model for studying Long-COVID in Veterans because, as we have shown in ME/CFS and GWI, PEM reveals pathophysiology not apparent at rest by challenging multiple physiological systems. The causes of PEM/CMIs are currently unknown, but converging evidence suggests that gut-microbiome perturbations and neuroinflammation act to sustain/worsen symptoms. Our central hypothesis is that neuroinflammation and gut-microbiome perturbations act to produce and maintain symptoms, and that dysfunction among these systems is best studied using an exercise challenge model. Our pilot data indicate that those with CMI: 1) report moderate-to-large symptom changes and worsened cognitive performance following a standardized exercise challenge; 2) show disturbed gut microbiome at rest and differential responses to exercise compared to controls, and 3) that peripheral inflammation (interleukin-6) is associated with augmented brain activity during fatiguing cognition in ME/CFS compared to controls. We intend to extend our exercise challenge research in CMI to PASC with the following specific aims: Aim 1: To determine the effects of a standardized exercise challenge on PEM (symptoms and cognition). Aim 2: To determine the effects of a standardized exercise challenge on gut microbiome structure and function. Aim 3: To determine the effects of a standardized exercise challenge on neuroinflammation. This study will significantly enhance our understanding of PASC and will begin to determine the pathophysiological mechanisms that underlie symptoms at rest and symptom worsening with physical effort. The COVID-19 pandemic offers a unique window of opportunity to evaluate pathophysiology early in disease development and with known proximity to the initiating event – i.e., COVID-19 infection. This is a rare occurrence in CMI research, and one that can provide critical mechanistic insight to aid in the development of targeted and personalized therapies.", "keywords": [ "2019-nCoV", "Acute", "Address", "Adverse effects", "Affect", "American", "Area", "Back", "Biological Markers", "Boston", "Brain", "COVID-19", "COVID-19 pandemic", "COVID-19 survivors", "Caring", "Characteristics", "Chicago", "Chronic", "Chronic Fatigue Syndrome", "Clinical", "Cognition", "Country", "Data", "Data Set", "Databases", "Development", "Disease", "Equilibrium", "Event", "Exercise", "Exertion", "Exhibits", "Fatigue", "Foundations", "Frequencies", "Functional disorder", "Gait", "Genetic", "Goals", "Health", "Impaired cognition", "Impairment", "Incidence", "Individual", "Inflammation", "Inflammatory", "Interleukin-6", "Intervention", "Intestines", "Investigation", "Life", "Long COVID", "Malaise", "Medical center", "Metagenomics", "Mission", "Modeling", "Neurologic", "Outcome", "Pain", "Participant", "Patient-Focused Outcomes", "Patients", "Peripheral", "Persian Gulf Syndrome", "Phenotype", "Physical Efforts", "Physical activity", "Physiological", "Population", "Positioning Attribute", "Positron-Emission Tomography", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Proteins", "Recording of previous events", "Recovery", "Registries", "Reporting", "Research", "Research Infrastructure", "Research Personnel", "Research Priority", "Resources", "Rest", "Risk", "Risk Factors", "SARS-CoV-2 infection", "Science", "Services", "Severities", "Standardization", "Structure", "Study models", "Symptoms", "System", "Testing", "United States Department of Veterans Affairs", "Veterans", "Veterans Health Administration", "Work", "brain fog", "cognitive performance", "combat", "comparison control", "data management", "data warehouse", "effective intervention", "empowerment", "experience", "functional disability", "functional independence", "genetic predictors", "gut microbiome", "improved", "individualized medicine", "insight", "microbiome alteration", "military veteran", "negative affect", "neuroinflammation", "pain symptom", "patient population", "persistent symptom", "personalized medicine", "post-COVID conditions", "precision medicine", "predictive modeling", "programs", "receptor", "response", "systemic inflammatory response", "targeted treatment" ], "approved": true } }, { "type": "Grant", "id": "13974", "attributes": { "award_id": "1IS1BX006324-01", "title": "ShEEP Request for MERSCOPE Instrument", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-03-01", "end_date": "2023-09-30", "award_amount": null, "principal_investigator": { "id": 30421, "first_name": "Franklin W", "last_name": "Huang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1522, "ror": "", "name": "VETERANS AFFAIRS MED CTR SAN FRANCISCO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Technological advances have now greatly expanded the frontier of single cell transcriptomics. We can now measure individual cells within their spatial context and directly observe cell-cell interactions. A leading technology in this area, named MERFISH, uses digital barcoding of mRNAs in the cell to measure gene expression at sub-cellular resolution. We propose to request the MERSCOPE instrument, which allows for MERFISH processing of hundreds of genes on tumor and tissue sections to advance our studies of cancer and other diseases that affect Veterans’ health. In situ hybridization (ISH)-based methods entail a process whereby a target sequence is detected by hybridization of a complementary fluorescent probe. The addition of sequential rounds of hybridization and imaging combined with barcoding have enabled substantial multiplexing. In multiplexed error-robust fluorescence ISH (MERFISH), successive rounds of hybridizations are imaged to detect the presence or absence of fluorescently labelled probes. The serial images are then decoded, using the error-robust barcode associated with each transcript identity. MERFISH has been used over a wide range of scales, from transcript location within individual cells to tissue-level spatial transcriptomics. Research projects advancing studies of diseases highly relevant to the Veterans’ community that will be supported by this instrument include studies focusing on cancers such as prostate and lung cancer, brain diseases, such as traumatic brain injury (TBI), frontotemporal dementia (FTD), and lung diseases. Spatial transcriptomics is required to simultaneously image multiple cells in affected tissues to determine cellular localization and gene expression. Lung transplant and pulmonary fibrosis studies will be served by this equipment to image specific cell types in lung transplant and fibrotic tissues. Infectious disease research projects related to HIV and SARS-CoV-2 will be able to utilize this instrument to better understand the pathogenic mechanisms of infection and persistence in tissues. Studies of prostate, hepatocellular, and lung cancer will also utilize this equipment to characterize prognostic biomarkers and understand the tumor microenvironment. We are excited to request the MERSCOPE, a state-of-the-art spatial transcriptomics instrument that will provide innovative and outstanding images for research studies to advance Veterans’ health. We anticipate the MERSCOPE to provide services essential towards accomplishing VA’s research goals to understand and treat diseases of high importance to the Veteran population.", "keywords": [ "2019-nCoV", "Address", "Affect", "Area", "Bar Codes", "Biological", "Brain Diseases", "COVID-19", "Cell Communication", "Cells", "Communicable Diseases", "Communities", "Community Services", "Computer software", "Custom", "Data", "Data Set", "Dedications", "Dementia", "Diagnosis", "Dimensions", "Disease", "Equipment", "Fluorescent Probes", "Fluorescent in Situ Hybridization", "Frontotemporal Dementia", "Funding", "Future", "Gene Expression", "Gene Expression Profiling", "Genes", "Goals", "HIV", "Health", "Health Services Research", "Image", "In Situ", "In Situ Hybridization", "Individual", "Infection", "Infectious Diseases Research", "Label", "Laboratory Research", "Location", "Lung Transplantation", "Lung diseases", "Malignant Neoplasms", "Malignant neoplasm of lung", "Malignant neoplasm of prostate", "Maps", "Measures", "Messenger RNA", "Methods", "Names", "Oligonucleotides", "Pathogenicity", "Primary carcinoma of the liver cells", "Process", "Prognostic Marker", "Pulmonary Fibrosis", "RNA", "Research", "Research Personnel", "Research Project Grants", "Resolution", "Resources", "San Francisco", "Services", "Sheep", "System", "Techniques", "Technology", "Tissues", "Transcript", "Traumatic Brain Injury", "United States Department of Veterans Affairs", "Urology", "Veterans", "Visualization", "cell type", "cellular imaging", "combinatorial", "complex data", "cost effective", "design", "digital", "experimental study", "frontier", "gene panel", "high resolution imaging", "innovation", "insight", "instrument", "interest", "laboratory facility", "lung injury", "military veteran", "research study", "serial imaging", "single molecule", "tool", "transcriptomics", "tumor", "tumor microenvironment" ], "approved": true } }, { "type": "Grant", "id": "14192", "attributes": { "award_id": "5I01HX003576-02", "title": "Impact of COVID-19 on Continuity of Care for Veterans on Antipsychotic Medications", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-01", "end_date": "2024-10-31", "award_amount": null, "principal_investigator": { "id": 26863, "first_name": "ANOUK L", "last_name": "GRUBAUGH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1782, "ror": "", "name": "RALPH H JOHNSON VA MEDICAL CENTER", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Background: Severe mental illnesses are consistently ranked as some of the most debilitating health conditions worldwide due to their early age of onset, chronicity, and impact on functioning. Fortunately, a number of antipsychotic medications have been found to be effective for managing the symptoms of severe mental illness (SMI) and for preventing relapse and rehospitalization. Despite their efficacy, treatment non-compliance for individuals on these medications is high due to a number of factors including poor insight into illness, negative attitudes about medication, and medication related side effects. Further complicating care and outcomes for this clinical population, providers must maintain close oversight of patients on antipsychotics due to the impact of these medications on metabolic and cardiac functioning which confer an increased risk of obesity, diabetes, heart problems, and other chronic illnesses. This oversight includes regular monitoring of weight, blood pressure, fasting blood glucose, and lipid levels. Additionally, clozapine, indicated for treatment-resistant schizophrenia, requires weekly-to-monthly monitoring of absolute neutrophil counts to prevent potentially fatal clozapine- induced agranulocytosis. Significance: The proposed project has significant and immediate relevance to Veterans and the VHA in that it seeks to better understand if and to what extent COVID-19 related care disruptions impacted care and outcomes for Veterans with SMI prescribed antipsychotic medications. Given pre- existing challenges in the treatment of this Veteran population, this is an important area of inquiry as well as one for which little is known. Added strengths of the proposed study include the use of a mixed methods approach that includes national level data from multiple sources. Aside from addressing a critical knowledge gap, the proposed study targets what is unarguably one of the most vulnerable patient populations within the VA and other healthcare systems—patients with SMI prescribed antipsychotic medications. Specific Aims: Aim 1: To assess the impact of COVID-19 related care disruptions on healthcare use and outcomes for Veterans on antipsychotic medications using robust statistical methods and national level data; Aim 2: To assess whether the impact of COVID-19 related care disruptions differ by race/ethnicity, gender, age, and rural/urban status using national level data; Aim 3: To conduct thematic interviews with provider and patient stakeholder groups at the national level to better understand COVID-19 related care disruptions. Provider stakeholders (e.g., psychiatrists, advanced nurse practitioners) will be interviewed to better understand COVID-19 related changes in practice behaviors, the perceived impact of these changes on care continuity and outcomes, and to solicit suggestions to mitigate the impact of interrupted care in the future; Veterans prescribed antipsychotic medication prescriptions in the pre COVID-19 window will be interviewed to better understand the impact of COVID-19 related care disruptions on treatment seeking behaviors, obstacles encountered with regard to access, and to explore other factors potentially impacting outcomes in this patient group. Methodology: The proposed study will employ a mixed-methods (quantitative/qualitative) approach. For Aims 1 & 2 we will employ retrospective, observational analyses using a national cohort of Veterans (N>250,000) with an ICD-CM-10 diagnostic code for schizophrenia or bipolar disorder prescribed a first-generation or second-generation antipsychotic [1/19-12/21]. Veterans of all ages, genders, racial groups, military eras will be included in the cohort. Aim 3 will involve individual thematic interviews with provider (n=35-45) and patient stakeholders (n=50-60). Next Steps/Implementation: Findings from this 2-year project will be of immediate relevance and impact for local, regional, and national level administrators and mental health providers as well as the VA Office of Mental Health and Suicide Prevention and VA Pharmacy Benefits Management Services. Collectively, data from this project will serve to identify potential strategies to further mitigate the impact of COVID-19 on the care and outcomes of Veterans with SMI as well as prepare for future public health and/or other national emergencies.", "keywords": [ "Address", "Adherence", "Administrator", "Admission activity", "Age", "Age of Onset", "Agranulocytosis", "Antipsychotic Agents", "Area", "Attitude", "Behavior", "Bipolar Disorder", "Blood Glucose", "Blood Pressure", "COVID-19", "COVID-19 impact", "Caring", "Chronic", "Chronic Disease", "Clinical", "Clozapine", "Code", "Continuity of Patient Care", "Data", "Data Sources", "Diabetes Mellitus", "Diagnostic", "Disease", "Drug Prescriptions", "Emergency Care", "Emergency Situation", "Ethnic Origin", "Event", "Fasting", "Future", "Gender", "Generations", "Guidelines", "Health", "Health Personnel", "Healthcare", "Healthcare Systems", "Heart", "Heart Diseases", "Individual", "Inpatients", "Interruption", "Interview", "Knowledge", "Lipids", "Malignant Neoplasms", "Mental Health", "Mental disorders", "Metabolic", "Methodology", "Methods", "Military Personnel", "Monitor", "Nurse Practitioners", "Outcome", "Outpatients", "Patients", "Pharmaceutical Preparations", "Pharmacists", "Population", "Provider", "Psychiatrist", "Public Health", "Race", "Research Design", "Resistance", "Rural", "Safety", "Schizophrenia", "Services", "Statistical Methods", "Suggestion", "Suicide", "Suicide prevention", "System", "Testing", "Veterans", "Visit", "Weight", "Woman", "care outcomes", "cohort", "cost", "economic impact", "ethnic minority", "experience", "health care availability", "health care delivery", "health care service utilization", "heart function", "hospital readmission", "insight", "military veteran", "mortality", "multiple data sources", "neutrophil", "non-compliance", "obesity risk", "patient population", "pharmacy benefit", "post-COVID-19", "prevent", "racial minority", "racial population", "relapse prevention", "rural area", "severe mental illness", "side effect", "symptom management", "urban dwelling" ], "approved": true } }, { "type": "Grant", "id": "14233", "attributes": { "award_id": "5I01RX003810-02", "title": "Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-01", "end_date": "2027-10-31", "award_amount": null, "principal_investigator": { "id": 26759, "first_name": "Russell S.", "last_name": "Richardson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26760, "first_name": "Joel Douglas", "last_name": "Trinity", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1781, "ror": "https://ror.org/007fyq698", "name": "VA Salt Lake City Healthcare System", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 induces profound vascular endothelial dysfunction, the long-term impact of which is unknown. Moreover, recovery from COVID-19 is delayed in a substantial number of COVID-19 patients (~ 30-40%) and characterized by persistent symptoms of fatigue, weakness, and neurocognitive deficits commonly referred to as “long-COVID”. The overall objective of this project is to evaluate the long-term consequences of COVID-19 in older Veterans and provide scientifically sound recommendations for vascular endothelial function-based rehabilitation in older Veterans after COVID-19 and older Veterans in general. The central hypothesis is that, given the fundamental role of oxidative stress and inflammation in long-COVID, vascular endothelial dysfunction following COVID-19 will be associated with long-term negative impacts on health and exercise-based rehabilitation with mitochondria-targeted antioxidant (Mito-Q) supplementation will synergistically improve peripheral and cerebral vascular endothelial dysfunction in older Veterans while convalescing from COVID-19. The rationale for this project is that improving COVID-19-induced vascular endothelial dysfunction by decreasing oxidative stress and inflammation with optimized rehabilitation has the potential to improve health in Veterans with long-COVID, and improve both morbidity and mortality in older Veterans. The central hypothesis will be tested by pursuing two Specific Aims: 1) determine the time course and health risks of vascular endothelial dysfunction in older Veterans with long-COVID, older Veterans who are COVID-recovered, and older Veterans who never had COVID and 2) determine the efficacy of exercise-based rehabilitation with and without Mito-Q supplementation to improve vascular endothelial function in older Veterans with long-COVID, older Veterans who are COVID-recovered, and older Veterans who never had COVID. Under Specific Aim 1, single passive leg movement (sPLM), flow-mediated dilation (FMD), and the breath-hold acceleration index (BHAI) will be used to evaluate microvascular, conduit artery, and cerebral vascular endothelial function in older patients twice annually for 4 years to determine long-term impact of COVID-19 on vascular endothelial function. Additionally, patient health risks, negative outcomes, [neurocognitive function, and pulmonary function] will be tracked during this time to determine the prognostic ability of the peripheral and cerebral vascular endothelial function assessments. For Specific Aim 2, microvascular (sPLM), conduit artery (FMD), and cerebral (BHAI) vascular endothelial function will be assessed before and after either exercise-based rehabilitation or exercise-based rehabilitation combined with Mito-Q supplementation to determine their efficacy to improve peripheral and cerebral vascular endothelial function in COVID-impacted Veterans and older Veterans in general. The research proposed in this application is innovative because it focuses on lead therapeutic candidates to rehabilitate peripheral and cerebral vascular endothelial function by combatting the underlying issue of a sustained elevation in oxidative stress and inflammation associated with aging and further impacted by COVID-19. The proposed research is significant because it is expected to provide scientifically sound recommendations for rehabilitation to improve health in older Veterans and those struggling to recover from COVID-19.", "keywords": [ "Acceleration", "Aging", "Antioxidants", "Arteries", "Blood Vessels", "COVID-19", "COVID-19 impact", "COVID-19 patient", "COVID-19 severity", "COVID-19 survivors", "COVID-19 treatment", "Cardiovascular system", "Cerebrum", "Chronic Disease", "Communities", "Convalescence", "Data", "Disease", "Disease Progression", "Dyspnea", "Elderly", "Event", "Fatigue", "Fostering", "Free Radicals", "Health", "High Prevalence", "Impairment", "Incidence", "Inflammation", "Inflammatory", "Knowledge", "Lead", "Leg", "Link", "Long COVID", "Mediating", "Mission", "Mitochondria", "Morbidity - disease rate", "Movement", "Neurocognitive", "Neurocognitive Deficit", "Outcome", "Oxidative Stress", "Patients", "Peripheral", "Play", "Predisposition", "Quality of life", "Reactive Oxygen Species", "Recommendation", "Recovery", "Rehabilitation therapy", "Reporting", "Research", "Risk", "Risk Factors", "Role", "SARS-CoV-2 positive", "Scientific Advances and Accomplishments", "Speed", "Supplementation", "Symptoms", "System", "Testing", "Time", "Vascular Endothelium", "Vasodilation", "Veterans", "age related", "body system", "cerebrovascular", "combat", "coronavirus disease", "cytokine", "efficacy evaluation", "evidence based guidelines", "exercise rehabilitation", "experience", "functional independence", "human old age (65+)", "improved", "indexing", "innovation", "long term consequences of COVID-19", "long-term sequelae", "military veteran", "mortality", "older patient", "persistent symptom", "prognostic value", "pulmonary function", "severe COVID-19", "sound", "therapeutic candidate", "vascular endothelial dysfunction" ], "approved": true } }, { "type": "Grant", "id": "14238", "attributes": { "award_id": "5I01RX003984-02", "title": "Comparing the effectiveness of telehealth to in-person delivery of a combined metacognitive and attention training in Veterans with mTBI/PTSD", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-01", "end_date": "2026-10-31", "award_amount": null, "principal_investigator": { "id": 26778, "first_name": "Julia Kay", "last_name": "Waid-Ebbs", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Background. Over 70% of Veterans with mild traumatic brain injury (mTBI), seeking services at the Veterans’ Health Administration, suffer from comorbid post-traumatic stress disorder (PTSD). These Veterans commonly experience concomitant executive dysfunction in goal setting, concentration, and attention that impairs their performance in complex daily tasks. Others and we have studied Goal Management Training (GMT) to address this problem. Collectively, the data have shown that GMT improved some aspects of executive function in mTBI/PTSD but did not restore cognition to normal during complex tasks. Goal management for performing complex tasks requires cognitive processes such as attention, and direct-attention training may be beneficial in improving cognition. GMT with attention training have been used in other studies, but those did not involve Veterans with either mTBI or mTBI/PTSD. We recently conducted a pilot study combining GMT and direct-attention training (GMT+ATT) in Veterans with mTBI and PTSD. We discovered a large treatment effect (Cohen d=2.23) in the NIH EXAMINER Executive Composite score and a significant treatment response in the NIH EXAMINER Cognitive Control subdomain and the Unstructured Task. GMT or ATT is typically administered in-person. In-person treatment can impose problems such as limited treatment access, poor cost-effectiveness, and unexpected situations (like the COVID-19 pandemic). As an alternative method, telehealth has been used increasingly to meet the need for care in Veterans living in rural areas and during the pandemic. Telehealth delivery of cognitive interventions in Veterans with mTBI or with PTSD has shown effectiveness that is comparable to that of in-person treatment. However, GMT+ATT has not been studied in these Veterans. Therefore, we have recently developed the format for telehealth delivery of GMT+ATT in Veterans with mTBI/PTSD. Our preliminary data demonstrate the feasibility of this delivery platform and similar treatment outcomes as compared to in-person therapy. Objective & Hypotheses. The objective of this randomized controlled trial is to determine and compare the effect of in-person and telehealth delivery of GMT+ATT in Veterans with mTBI/PTSD. Hypothesis 1a. In-person GMT+ATT will improve cognition vs. control group (Brain Health Workshop (BHW). Hypothesis 1b. Telehealth GMT+ATT will improve cognition vs. BHW control group Hypothesis 2. Telehealth delivery of GMT+ATT will produce response comparable to in-person treatment. Primary measure. The NIH EXAMINER executive composite score will assess overall executive function with subdomains such as complex task performance requiring goal management, as well as tests underlying cognitive control such as attention and working memory. Secondary functional measures. 1) Unstructured Task and 2) Test of Grocery Shopping Skills (ToGSS), which captures naturalistic real-world function. Exploratory Objective. To study the capability of the Attention Network Task to predict treatment response to GMT+ATT. Methods. 63 Veterans will be randomized to 10 weeks of in-person or telehealth delivery of GMT+ATT or BHW control. Outcomes will be assessed at pre-, post-, 6 month-post and 1-year post-treatment. GMT and ATT will each be provided in ten, weekly, 2-hour sessions (4hrs/week as combined). Significance. This study uses a novel combinational treatment of GMT+ATT to restore the executive and attentional processes required for complex daily tasks in Veterans with mTBI/PTSD. This work meets a key VA RR&D priority of providing quality care to Veterans. Positive study results may help shape clinical practice of cognitive rehabilitation in terms of treatment strategy, delivery platform, access to care, and means to predict treatment response. Such impacts will translate to significant cost-savings for the VA healthcare system and improvement in quality of life in Veterans.", "keywords": [ "Address", "Aftercare", "Attention", "Awareness", "COVID-19 pandemic", "Caring", "Clinical", "Cognition", "Cognitive", "Combined Modality Therapy", "Complex", "Control Groups", "Cost Savings", "Data", "Department of Defense", "Dissociation", "Educational workshop", "Effectiveness", "Evaluation", "Executive Dysfunction", "Goals", "Health Services Accessibility", "Healthcare Systems", "Hour", "Impaired cognition", "Impairment", "Intervention", "Life", "Measures", "Methods", "Military Personnel", "Neuropsychology", "Outcome", "Performance", "Persons", "Pilot Projects", "Population", "Post-Traumatic Stress Disorders", "Prediction of Response to Therapy", "Problem Solving", "Process", "Productivity", "Protocols documentation", "Psyche structure", "Quality of Care", "Quality of life", "Randomized", "Randomized Controlled Trials", "Recommendation", "Regimen", "Rehabilitation therapy", "Reporting", "Research", "Research Design", "Services", "Shapes", "Short-Term Memory", "Task Performances", "Testing", "Training", "Translating", "Translations", "Treatment outcome", "United States Department of Veterans Affairs", "United States National Institutes of Health", "Veterans", "Veterans Health Administration", "Work", "brain health", "clinical practice", "cognitive control", "cognitive process", "cognitive rehabilitation", "comorbidity", "compare effectiveness", "computerized", "cost effectiveness", "current pandemic", "directed attention", "executive function", "experience", "flexibility", "health goals", "improved", "indexing", "innovation", "instrument", "mild traumatic brain injury", "military veteran", "mind control", "neurobehavioral", "novel", "pandemic disease", "randomized controlled study", "response", "rural area", "skills", "social", "systematic review", "telehealth", "treatment effect", "treatment response", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "14252", "attributes": { "award_id": "5I21RX004092-02", "title": "Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-10-01", "end_date": "2024-09-30", "award_amount": null, "principal_investigator": { "id": 26752, "first_name": "Marianne", "last_name": "Goodman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1533, "ror": "", "name": "JAMES J PETERS VA MEDICAL CENTER", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "At present, 34.6 million people in the United States, and 273,232 Veterans tested or treated in Veteran Affairs facilities contracted COVID-19. While the exact prevalence of Post-Acute COVID-19 Syndrome (PACS) among Veterans is unknown, estimates of psychiatric/neurological PACS using a large global sample of COVID-19 patients (N=236,379) suggest a prevalence of approximately 11,390,400 Americans, and 90,311 Veterans in VA care, with rates likely to increase over time. Moreover, large scale studies suggest up to 35% of individuals experience functional impairment 8 months after COVID-19, and high prevalence of post-infection mental illness including anxiety disorders, depression, and post-traumatic stress disorder. Using longitudinal data from our academic affiliate, Icahn School of Medicine at Mount Sinai’s COVID registry (n≈1200), and local James J. Peters VA’s Clinical PACS program, coupled with our expertise in recovery-based psychotherapy, we are uniquely poised to develop an innovative treatment for Veterans struggling with PACS. Our intervention aims to improve psychological adjustment to PACS symptoms, promote resiliency, and facilitate coping, all of which can impact functional status and quality of life. The PACS-Coping and Recovery (PACS-CR) intervention we aim to develop focuses on psychological adjustment and coping, and augments medical, rehabilitative and neurological treatment for this population. Our approach is based on the CHIME model of personal recovery which includes five overarching processes: 1) Connectedness; 2) Hope and optimism about the future; 3) Identity; 4) Meaning in life; and 5) Empowerment. We will target the CHIME processes using established psychotherapeutic techniques such as skills training, acceptance-based and identity-based principles. Based on adaptations from existing recovery-based and COVID-19 distress group interventions that our team has developed and piloted, we are proposing a treatment framework that consists of a core of twelve 90-minutes sessions (1x/week x 12 weeks) with additional weekly sessions on specialized topics that are optional. We are proposing a treatment development NIH Stage 1A study to develop a Post-Acute COVID-19 Syndrome psychotherapeutic intervention, “PACS Coping and Recovery” (PACS-CR) through an iterative development process while collecting pilot data to assess its acceptability and feasibility. Our treatment development SPiRE will focus on 1) determining the treatment needs of Veterans with PACS, 2) developing the treatment using pilot qualitative data and aided by stakeholder feedback, 3) refining the intervention by three iterative pilots of our groups, testing both in person and telehealth versions. Pre and post measures will be utilized to track functional improvement and the degree to which this recovery-focused intervention has enabled the veterans to engage in meaningful life changes.", "keywords": [ "Activities of Daily Living", "Acute", "Address", "American", "Anxiety", "Anxiety Disorders", "COVID-19", "COVID-19 patient", "Cardiovascular system", "Caring", "Chaplain", "Chronic", "Climacteric", "Clinical", "Consultations", "Contracts", "Coping Skills", "Coupled", "Data", "Development", "Disease", "Distress", "Education", "Educational process of instructing", "Employment", "Epidemiology", "Fatigue", "Feedback", "Fostering", "Future", "Goals", "Headache", "Health", "High Prevalence", "Impairment", "Individual", "Infection", "Intervention", "Interview", "Knowledge", "Leadership", "Life", "Life Style", "Loneliness", "Long COVID", "Longitudinal Studies", "Measures", "Medical", "Memory impairment", "Mental Depression", "Mental Health", "Mental disorders", "Modeling", "Needs Assessment", "Neurologic", "Neurologic Symptoms", "Nutritionist", "Pain", "Pain Disorder", "Participant", "Patients", "Persons", "Phase", "Population", "Post-Traumatic Stress Disorders", "Prevalence", "Process", "Protocols documentation", "Provider", "Psychological adjustment", "Psychotherapy", "Quality of life", "Recovery", "Registries", "Rehabilitation therapy", "Sampling", "Services", "Sleep Disorders", "Sleeplessness", "Specialist", "Symptoms", "Techniques", "Testing", "Time", "United States", "United States Department of Veterans Affairs", "United States National Institutes of Health", "Veterans", "acceptability and feasibility", "arm", "arthropathies", "cohort", "common symptom", "coping", "coronavirus disease", "design", "empowerment", "experience", "fitness", "flexibility", "follow-up", "functional disability", "functional improvement", "functional restoration", "functional status", "group intervention", "health assessment", "improved", "improvement on sleep", "innovation", "interdisciplinary approach", "intervention refinement", "medical schools", "novel", "optimism", "physical conditioning", "post SARS-CoV-2 infection", "programs", "promote resilience", "psychosocial", "pulmonary symptom", "relapse prevention", "resilience", "satisfaction", "skills", "skills training", "symptomatology", "telehealth", "therapy development", "whole health" ], "approved": true } } ], "meta": { "pagination": { "page": 1404, "pages": 1424, "count": 14236 } } }