Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1392&sort=-program_reference_codes
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-program_reference_codes", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-program_reference_codes", "next": null, "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1391&sort=-program_reference_codes" }, "data": [ { "type": "Grant", "id": "11781", "attributes": { "award_id": "3U24NS107230-05S1", "title": "Mid-America Regional Coordinating Center (MARCC)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 27658, "first_name": "Joanna", "last_name": "Vivalda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-04-01", "end_date": "2023-07-31", "award_amount": 95333, "principal_investigator": { "id": 27659, "first_name": "Jin-Moo", "last_name": "Lee", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27660, "first_name": "Peter David", "last_name": "Panagos", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 827, "ror": "", "name": "WASHINGTON UNIVERSITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "Subacute neurological changes due to COVID-19 (six months – one year post infection) remain poorly characterized. This may be increasingly important as previous pandemics, e.g. 1918 influenza, have demonstrated that neurological conditions (e.g. delirium, encephalitis, and neurodegenerative conditions) are more prevalent during the subacute and chronic (> one year) phases. Anecdotal accounts of COVID-19 positive patients have suggested that “brain fog” and fatigue develop during the subacute period, especially in more severely affected individuals. This proposal leverages two existing cohorts of patients enrolled at Barnes-Jewish Hospital and the Infectious Disease Clinical Research Unit at Washington University in Saint Louis. An acute cohort consists of participants who present to the emergency room with symptoms consistent with COVID-19 and who are followed throughout their hospital stay, if admitted, and post infection in the outpatient setting. A second cohort, a convalescent cohort, is enrolling confirmed COVID-19 positive participants who were primarily asymptomatic or mildly symptomatic and who are followed post infection in the outpatient setting. This proposal has three aims. Aim 1 will evaluate subacute cognitive changes observed six months post infection in COVID- 19 positive patients. Aim 2 will evaluate subacute neuroimaging changes observed six months post infection in COVID-19 positive patients. Aim 3 will evaluate subacute multi-omic blood changes observed six months post infection in COVID-19 positive patients. Overall, we hypothesize that COVID-19 positive patients with more severe symptoms (intensive care unit (ICU) admission) will have more cognitive deficits, neuroimaging changes, and blood transcriptomic, proteomic, metabolomic, and lipidomic abnormalities at six months post infection compared to COVID-19 positive patients who were hospitalized or who were asymptomatic. This proposal is therefore a time sensitive opportunity to characterize the neurological changes seen at six months post infection within 100 patients from these diverse cohorts of COVID-19 positive individuals.", "keywords": [ "Accident and Emergency department", "Acute", "Admission activity", "Affect", "Blood", "COVID-19", "COVID-19 patient", "Chronic", "Clinical Research", "Cognitive deficits", "Communicable Diseases", "Delirium", "Encephalitis", "Enrollment", "Fatigue", "Hospitalization", "Hospitals", "Individual", "Infection", "Influenza", "Intensive Care Units", "Length of Stay", "Nerve Degeneration", "Neurologic", "Outpatients", "Participant", "Patients", "Phase", "Proteomics", "SARS-CoV-2 positive", "Symptoms", "Time", "Universities", "Washington", "brain fog", "cognitive change", "cohort", "follower of religion Jewish", "lipidomics", "metabolomics", "multiple omics", "neuroimaging", "participant enrollment", "previous pandemic", "transcriptomics" ], "approved": true } }, { "type": "Grant", "id": "11782", "attributes": { "award_id": "3U24GM132176-04S1", "title": "National Research Mentoring Network (NRMN) Coordination Center Supplement", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22735, "first_name": "Michael A.", "last_name": "Sesma", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-04-01", "end_date": "2024-06-30", "award_amount": 177110, "principal_investigator": { "id": 27661, "first_name": "CHRISTINE E", "last_name": "PFUND", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 799, "ror": "", "name": "UNIVERSITY OF WISCONSIN-MADISON", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "7. Project Summary/Abstract: A key component of a successful, competitive workforce is diversity. Across fields, including the sciences, diversity has been linked to higher levels of problem-solving, innovation, and creativity, decision-making, and quality of work (1-4). The National Research Mentoring Network (NRMN) Phase II initiative (2019-2024), part of the broader Diversity Program Consortium (DPC), is one such effort that seeks to assess the efficacy of mentorship education and career development interventions across 11 U01 research projects. Understanding factors that significantly contribute to career persistence, success, and progression of groups over time requires more than just cross-sectional data across individual interventions. Specifically, it requires data from large, diverse groups over extended periods of time with different experiences and varied degrees of engagement in targeted interventions. To realize the potential in these data, the efforts of participant consent language, measurement alignment, data collection, data aggregation, and dissemination need to be coordinated. When implemented effectively, a coordinated approach provides the opportunity to study individual research projects collectively as one larger study and therefore recognize trends longitudinally and at scale otherwise not possible. NRMN Phase II, and its use of a coordination center to collect common measures data, provided an opportunity to engage in this interrelated work. The COVID-19 pandemic significantly impacted the NRMN community including its 11 U01 research studies, the NRMN Resource Center (RC), and therefore, the NRMN Coordination Center (CC). In response, the NRMN CC altered its plan of work within the scope of its aims and was able to support the community in exciting but unanticipated ways. The NRMN CC now finds itself in the position of needing to increase its capacity in the final 15 months of the grant period to accommodate changes to the timelines for participant recruitment and enrollment, implementation of interventions, and data collection, as well as the size and scope of those data. The proposed work responds to the remaining NRMN community needs arising from COVID-19 while maximizing the collective impact of NRMN Phase II. Funding for this work will support completion of the Specific Aims, despite the delayed timelines due to COVID-19, adding the additional personnel and resources required to effectively collect, store, track and report NRMN Phase II data from research studies whose timelines were affected by the pandemic. This supplement will also provide support for the infrastructure and expertise needed to capitalize on the common data collected, develop sustainable tools for the dissemination of NRMN Phase II products and findings, and study NRMN’s collective impact.", "keywords": [ "Affect", "Bibliometrics", "Biomedical Research", "COVID-19", "COVID-19 pandemic", "Collaborations", "Collection", "Communication", "Communities", "Community Networks", "Community of Practice", "Consent", "Creativeness", "Data", "Data Aggregation", "Data Analyses", "Data Collection", "Decision Making", "Development", "Education", "Evaluation", "Fostering", "Funding", "Goals", "Grant", "Human Resources", "Individual", "Infrastructure", "Intervention", "Language", "Leadership", "Libraries", "Link", "Longitudinal trends", "Measurement", "Measures", "Mentors", "Mentorship", "Modality", "Participant", "Patient Recruitments", "Phase", "Positioning Attribute", "Problem Solving", "Reporting", "Research", "Research Project Grants", "Resources", "Science", "Shapes", "Surveys", "Time", "Trust", "Work", "Workforce Development", "career", "career development", "cohort", "community building", "data management", "efficacy evaluation", "evidence base", "experience", "implementation intervention", "innovation", "interest", "meetings", "pandemic disease", "pandemic impact", "participant enrollment", "participant retention", "phase 2 study", "programs", "research study", "response", "science education", "success", "synergism", "therapy development", "timeline", "tool" ], "approved": true } }, { "type": "Grant", "id": "11783", "attributes": { "award_id": "7R01EB029122-04", "title": "Ultrasound-controlled remote activation of CAR T cells for localized tumor immunotherapy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [ { "id": 27662, "first_name": "Tuba Halise", "last_name": "Fehr", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-04-01", "end_date": "2024-05-31", "award_amount": 452295, "principal_investigator": { "id": 25082, "first_name": "Yingxiao", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 760, "ror": "https://ror.org/0168r3w48", "name": "University of California, San Diego", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Ultrasound-Controlled Remote activation of CAR T-cells for localized tumor immunotherapy Chimeric antigen receptor (CAR) T cells show potential as paradigm-shifting therapeutic agents for cancer treatment. CAR-T based immunotherapy, however, can have off-target activity against normal cells and cause life-threatening adverse reactions such as cytokine storms. To mitigate this side effect, we propose to explore high-precision focused ultrasound as a means to confine CAR T cell activation within solid tumor tissue space. In the proposed work, we will use ultrasound to deliver energy safely and noninvasively into small volumes of tissue deep inside the body. We will develop technology and protocols for ultrasound-guided remote-activation of CAR expression in T-cells, which are clinically compatible and able to convert ultrasound waves into short pulses of local heat generation. Specifically, we will engineer molecular thermo-sensors (acousto-sensors) into T-cells along with genetic transducing modules (GTMs), and use focused ultrasound to produce short pulsed heat to activated CAR therapeutic response for focal targeting on solid tumors. We will incorporate reporters to provide direct detection of therapeutic responses, and use the information to calibrate and optimize the system. Therefore, three specific aims are proposed: (1) Develop ultrasound-activatable thermo-sensors and GTMs; (2) Engineer ultrasound-activatable CAR T-cells; (3) Examine the immunotherapeutic efficacy CAR T-cells against solid tumors in vivo. Upon success, this first-of-kind research will specifically transduce remote ultrasound stimulation into genetic expression of T-cells for locally controlled immunotherapy. This approach to solid tumor immunotherapy is expected to open new opportunities to integrate engineering with medicine, and result in many successful translations from fundamental science and engineering to applications with clinical utility.", "keywords": [ "Adverse reactions", "Antibodies", "Antigens", "Biosensor", "Calibration", "Cancer Relapse", "Cell surface", "Cells", "Clinical", "Coupled", "Coupling", "Detection", "Engineering", "Evolution", "Fluorescence Resonance Energy Transfer", "Focused Ultrasound", "Gene Activation", "Generations", "Genetic", "Genetic Transduction", "Homing", "Human body", "Image", "Immunotherapeutic agent", "Immunotherapy", "Interleukin-12", "Left", "Life", "Malignant Neoplasms", "Medicine", "Microbubbles", "Modeling", "Molecular", "Mus", "Non-Malignant", "Normal Cell", "Patients", "Pattern", "Physiologic pulse", "Piezo 1 ion channel", "Positioning Attribute", "Precancerous Conditions", "Production", "Property", "Protocols documentation", "Reporter", "Reporting", "Research", "Science", "Signal Transduction", "Site", "Solid Neoplasm", "Surface Antigens", "System", "T memory cell", "T-Cell Activation", "T-Lymphocyte", "Technology", "Therapeutic Agents", "Tissues", "Transcription Coactivator", "Transducers", "Translations", "Treatment Efficacy", "Tumor Tissue", "Ultrasonic Transducer", "Ultrasonic wave", "Work", "cancer immunotherapy", "cancer therapy", "cell killing", "chimeric antigen receptor", "chimeric antigen receptor T cells", "clinical application", "cofactor", "cytokine release syndrome", "engineered T cells", "improved", "in vivo", "mechanical energy", "mechanical force", "mechanical load", "neoplasm immunotherapy", "neoplastic cell", "pressure", "receptor", "receptor expression", "remote delivery", "sensor", "side effect", "success", "treatment response", "tumor", "tumor eradication", "ultrasound" ], "approved": true } }, { "type": "Grant", "id": "11784", "attributes": { "award_id": "5K01MH127306-04", "title": "Effects of adolescent social isolation on adult decision making and corticostriatal circuitry", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 24237, "first_name": "Ashlee V", "last_name": "Van't Veer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-03-15", "end_date": "2025-06-30", "award_amount": 179874, "principal_investigator": { "id": 24238, "first_name": "Elizabeth N.", "last_name": "Holly", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1061, "ror": "", "name": "RUTGERS THE STATE UNIV OF NJ NEWARK", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "Adolescence is a particularly important period in social and cognitive development, characterized in part by rapid increases in exploration, social interaction, and neural connectivity. Social isolation in adolescence has a clear, profound impact on a wide range of behavioral and physiological endpoints extending into adulthood. The overarching research goal of this proposal is to elucidate how adolescent social isolation in male and female mice alters value-based decision making in adulthood, as well as the underlying corticostriatal circuitry driving these complex goal-directed behaviors. This work is timely and vitally important as COVID-19 has subjected an increasing number of adolescents to social isolation through school closures and stay-at-home orders. A first aim of this proposal is to use operant tasks to systematically investigate how adolescent social isolation impacts how mice later value reward benefits and integrate expected costs during decision making. Preliminary data suggests that adolescent social isolation amplifies reward value, but specific aspects of decision-making behavior will be disentangled with computational modeling of value-based choice. The second aim builds on this behavioral work to test the hypothesis that adolescent social isolation disrupts corticostriatal circuitry and striatal output during adult value-based decision-making. A distributed neural network is engaged during decision- making, and the dorsomedial striatum (DMS) is a key node in this network. Prefrontal inputs to the DMS from the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) are critically involved in action selection and outcome valuation, respectively. All three of these nodes undergo maturation and refinement during adolescence, and adolescent social isolation disrupts this development. However, how this impacts adult corticostriatal function remains unknown. Using in vivo electrophysiology, local field potential (LFP) and single- unit recordings will be used to test how adolescent social isolation affects synaptic strength and connectivity from these cortical regions to the DMS during value-based decision-making behavior. This work proposed in the Mentored Research Scientist Development Award will provide Dr. Elizabeth Holly with training in computational modeling of decision-making behavior and in vivo electrophysiology, which will be an important part of the foundation of her independent research career. By completion of this Award, the goal is for Dr. Holly to transition to a tenure-track faculty position and apply for an R01. The mentorship team Dr. Holly has assembled will ensure her successful training in these techniques, and prepare her to transition to her own independent research laboratory.", "keywords": [ "Adolescence", "Adolescent", "Adult", "Affect", "Automobile Driving", "Award", "Behavior", "Behavioral", "COVID-19", "COVID-19 impact", "Choice Behavior", "Cognitive", "Communication", "Complex", "Computer Models", "Corpus striatum structure", "Costs and Benefits", "Coupling", "Data", "Decision Making", "Dendritic Spines", "Development", "Electrophysiology (science)", "Ensure", "Faculty", "Female", "Foundations", "Goals", "Habits", "Holly", "Human", "Impairment", "Intervention", "Laboratory Research", "Learning", "Life", "Long-Term Effects", "Measures", "Medial", "Mediating", "Mental Health", "Mentored Research Scientist Development Award", "Mentorship", "Modeling", "Motivation", "Motor", "Mus", "Neurons", "Outcome", "Output", "Performance", "Phase", "Physiological", "Positioning Attribute", "Prefrontal Cortex", "Process", "Research", "Rewards", "Rodent", "Signal Transduction", "Social Development", "Social Interaction", "Social isolation", "Stimulus", "Stress", "Synapses", "Techniques", "Testing", "Thalamic structure", "Training", "Work", "career", "cognitive development", "cost", "discounting", "expectation", "experimental study", "flexibility", "in vivo", "male", "neural", "neural circuit", "neural network", "optogenetics", "physical conditioning", "response", "school closure", "stay-at-home order", "tenure track" ], "approved": true } }, { "type": "Grant", "id": "11785", "attributes": { "award_id": "5R01AA030452-02", "title": "GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging young African American women in a virtual group app to address alcohol misuse, sexual risk, and PrEP in NC", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 9179, "first_name": "Deidra", "last_name": "Roach", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2027-06-30", "award_amount": 614879, "principal_investigator": { "id": 26284, "first_name": "Felicia Amira", "last_name": "Browne", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 809, "ror": "", "name": "RESEARCH TRIANGLE INSTITUTE", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "The intersection between alcohol and other drug (AOD) use among young African American women at risk for HIV is a public health issue. Recent epidemiological data highlight increases in alcohol misuse among young African American women, especially since COVID-19. These issues are coupled with persistent disparities in HIV and other sexually transmitted infections (STIs) for young African American women. Eliminating persistent disparities in HIV acquisition is key to ending the HIV epidemic, particularly in the U.S. South. Consequently, there is a critical need to decrease alcohol use and impaired sex and to increase pre-exposure prophylaxis (PrEP) uptake as prevention for this key population. The proposed study builds on decades of research of a best-evidence woman-focused intervention, including collaboration with health departments to address AOD use, sexual risk, and violence prevention. Most recently, the study team found the delivery of the intervention via mobile health (mHealth) had findings comparable with face-to-face delivery, with reduced odds of heavy alcohol use and impaired sex, suggesting that scalability via mHealth is a viable option. The next logical step is to add and test a virtual group component, as recent participant feedback across several studies with African American women in North Carolina has shown additional group engagement and support is highly desired. Consequently, in response to RFA-AA-21-016: HIV Prevention and Alcohol, this application addresses the following specific aims: Aim 1. To modify an evidence-based mHealth AOD use and sexual risk reduction intervention to include a virtual group component and information about PrEP for utilization. Initial research activities include focus group discussions with 24 African American young women who misuse alcohol and 16 service providers, as well as pretesting of the virtual group component. This brief iterative process will include modifications and refinements based on content (PrEP) and technology (from tablet to smartphone) and will include review from our Community Collaborative Board. Aim 2. To test the modified mHealth intervention (with the group component) relative to the mHealth intervention in a two-arm randomized trial with young African American women (aged 18 to 30) who misuse alcohol. A total of 500 participants who are HIV-negative who engage in heavy alcohol use will be enrolled across two North Carolina counties and referred to their local health departments for PrEP. Primary biobehavioral outcomes assessed will include reduced alcohol use (self-reported and biological, including PEth), increased PrEP uptake (self-reported and biological), and reduced sexual risk (self-reported condomless sex and impaired sex and biological testing for HIV/STIs) at 3-, 6-, 9-, and 12-month follow-ups. Aim 3. To assess acceptability, adoption, and cost of the virtual group component as a strategy to increase engagement with the mHealth intervention and PrEP utilization. Acceptability will be assessed via satisfaction surveys and post-study interviews, adoption via data analytics measuring engagement in the group and examined as a meditator of intervention outcomes, and cost via data collected about time and resources of implementing the group component.", "keywords": [ "AIDS prevention", "Address", "Adoption", "Affect", "African American", "African American population", "Alcohol consumption", "Alcohols", "Area", "Asian", "Behavior Therapy", "Biological", "Biological Testing", "COVID-19", "COVID-19 morbidity", "COVID-19 risk", "Cellular Phone", "Centers for Disease Control and Prevention (U.S.)", "Classification", "Collaborations", "Communities", "County", "Coupled", "Data", "Data Analytics", "Disparity", "Drug usage", "Enrollment", "Epidemic", "Evidence based intervention", "Feedback", "Focus Groups", "Goals", "HIV", "HIV Seronegativity", "HIV diagnosis", "HIV/AIDS", "Health", "Heavy Drinking", "Human immunodeficiency virus test", "Impairment", "Incidence", "Individual", "Intervention", "Interview", "Measures", "Methods", "Modification", "North Carolina", "Outcome", "Outcome Assessment", "Participant", "Patient Self-Report", "Persons", "Population", "Populations at Risk", "Prevention", "Process", "Public Health", "Reduce health disparities", "Research", "Research Activity", "Research Priority", "Resources", "Risk", "Risk Reduction", "Sexually Transmitted Diseases", "Social support", "Support Groups", "Surveys", "Tablets", "Technology", "Testing", "Time", "United States National Institutes of Health", "Unsafe Sex", "Violence", "Woman", "Work", "aged", "alcohol and other drug", "alcohol misuse", "arm", "biobehavior", "cost", "critical period", "efficacy evaluation", "epidemiologic data", "evidence base", "experience", "implementation outcomes", "innovation", "intervention delivery", "mHealth", "mortality", "multi-racial", "peer support", "pre-exposure prophylaxis", "prevent", "prevention service", "randomized trial", "reduced alcohol use", "research study", "response", "satisfaction", "service providers", "sex", "uptake", "violence prevention", "virtual", "young woman" ], "approved": true } }, { "type": "Grant", "id": "11786", "attributes": { "award_id": "5R21AG078638-02", "title": "Role of PD1 blockade and IL-10 during infection in aging", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 23647, "first_name": "MULUALEM ENYEW", "last_name": "Tilahun", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2024-05-31", "award_amount": 187363, "principal_investigator": { "id": 26533, "first_name": "Christina", "last_name": "Camell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 764, "ror": "https://ror.org/017zqws13", "name": "University of Minnesota", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "The elderly are at high risk for mortality to infection, with influenza and pneumonia consistently ranked among the top leading causes of death in the US for those over 65. There is also an increased rate of co-infections in the elderly admitted to the ICU that is associated with hospital mortality. There is a need for novel approaches that rejuvenate the aged immune system to promote the control of infection. We leverage an experimental paradigm that exposes experimental mice to multiple microbes (termed normal microbial experience; NME). NME activates the immune system in young mice, increasing functional memory T cells. However, in old mice, NME-exposure leads to 100% mortality that is preceded by a cytokine storm and increased immune infiltrates in multiple tissues. Existing evidence demonstrates that immunosenescence, including inflammaging and the dysfunctional immune system, play a causal role in morbidity to infections in the elderly. Exhaustion is a cell fate that is increased in lymphocytes from the elderly, and which contributes to inflammaging, virus persistence, and tissue pathology. It is primarily enforced by chronic antigen exposure, but also regulated by local secreted factors, like IL-10 in younger individuals. It is unknown how specific factors control exhaustion prior to and during infection in older individuals. We speculate that IL-10, a traditional anti-inflammatory cytokine that accumulates with age, and which also has pro-cytotoxic effects on CD8 T cells, is a regulator of exhaustion with age. This proposal is based on our exciting preliminary data which describes the effect of PD1 blockade, which reduces exhaustion by restoring T cell activation and implicates IL-10 in that response. Based on our data, we wonder: does IL-10 promotes exhaustion or prevents it? We hypothesize that PD1 blockade relieves CD8+ T cell exhaustion in an IL-10/IL-10R dependent manner. We will use the experimental paradigm of NME-exposure to test this hypothesis. Aim 1 is to establish the role for IL-10/IL-10R in supporting T cell function during aging. Aim2 is to determine the mechanism by which IL-10 supports T cell function in aged mice.", "keywords": [ "2019-nCoV", "Address", "Admission activity", "Adoptive Transfer", "Affect", "Age", "Aging", "Anti-Inflammatory Agents", "Antigens", "CD8-Positive T-Lymphocytes", "COVID-19 pandemic", "Cause of Death", "Cell Separation", "Cell model", "Cell physiology", "Cells", "Cellular Indexing of Transcriptomes and Epitopes by Sequencing", "Chronic", "Chronic Disease", "Combined Modality Therapy", "Complement", "Data", "Elderly", "Exposure to", "Foundations", "Future", "Gene Expression Profile", "Genes", "Goals", "Hospital Mortality", "Hospitalization", "Human", "Immune", "Immune system", "Immunotherapy", "In Vitro", "Individual", "Infection", "Infection Control", "Inflammaging", "Influenza", "Interleukin-10", "Knock-out", "Lymphocyte", "Lymphocyte Subset", "Measures", "Microbe", "Morbidity - disease rate", "Mus", "PD-1 blockade", "PI3 gene", "Pathology", "Pathway interactions", "Patients", "Play", "Pneumonia", "Proliferating", "Proto-Oncogene Proteins c-akt", "Receptor Activation", "Receptor Signaling", "Recombinants", "Rejuvenation", "Risk", "Role", "STAT3 gene", "Sepsis", "Signal Pathway", "Signal Transduction", "Source", "Stains", "T memory cell", "T-Cell Activation", "T-Cell Receptor", "T-Lymphocyte", "Testing", "Therapeutic Uses", "Tissues", "Transcriptional Activation", "Translations", "Tumor-infiltrating immune cells", "Virus", "Work", "aged", "cancer immunotherapy", "cell type", "chronic infection", "co-infection", "cytokine", "cytokine release syndrome", "cytotoxic", "differential expression", "effector T cell", "exhaust", "exhaustion", "experience", "high risk", "immunosenescence", "improved", "improved outcome", "infectious disease treatment", "microbial", "mortality", "mortality risk", "mouse model", "novel strategies", "novel therapeutics", "prevent", "programmed cell death protein 1", "protective effect", "response", "seasonal influenza", "secondary infection", "severe COVID-19", "synergism", "young adult" ], "approved": true } }, { "type": "Grant", "id": "11787", "attributes": { "award_id": "5R01AG075002-02", "title": "The effects of the Covid-19 pandemic on formal and informal care among adults with dementia", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 26416, "first_name": "EMERALD THAI HAN", "last_name": "Nguyen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2027-05-31", "award_amount": 530192, "principal_investigator": { "id": 9026, "first_name": "HwaJung", "last_name": "Choi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Adults with Alzheimer’s diseases and related dementia (ADRD) are among the most vulnerable individuals from the pandemic. Both formal and informal care for adults with ADRD has been profoundly affected by the Covid-19 pandemic. Despite the need of frequent hands-on care for these adults due to their limitations in physical and cognitive functioning, in-home care services are limited and nursing home care has been risky during the pandemic. The social and economic circumstances of many families also have been changed due to the pandemic and hence their resources to care for a family member with ADRD. Disrupted care for adults with ADRD may have adverse health consequences that may last beyond the pandemic period. A better understanding of the effects of the pandemic on the dynamics between formal and informal care is critically important to address unmet care needs for adults with ADRD during and after the pandemic. We will first create a contextual measure of exposure to the pandemic (pre-, low-, high-, post-exposure) by taking into account the infection risks of the virus in the local area and develop a tailored geographic boundary for each individual that encompasses health and healthcare implications more directly relevant to the individual. We will then examine differences in healthcare utilization associated with the level of exposure to the pandemic. We will also assess the mediating and moderating role of formal and informal care resources (e.g., hospital capacity, family availability) in the pandemic’s effects on healthcare utilization. It will then examine the extent to which health, mortality, and healthcare costs of adults with ADRD were affected by the exposure to the pandemic, including potential differential effects across demographic (gender, racial/ethnic) and economic groups. The proposed study uses an innovative, comprehensive approach to assess the Covid-19 pandemic effects. It will develop a fine-grained contextual measure of exposure to the pandemic by using a daily infection risk in a local area (tract, ZIP code, county) where an adult with ADRD lives and addressing spillover effects of neighboring areas. It provides a nuanced understanding of the pandemic’s effect on healthcare utilization by incorporating information on the time-course of dementia (exposure at the onset vs. exposure during the subsequent years of dementia). The study will provide important data on the underlying mechanisms of the pandemic’s effect on healthcare utilization and health, and will identify sociodemographic and economic groups that are the most affected. Therefore, it will inform health policies and intervention programs aimed at improving healthcare systems to mitigate adverse effects of the pandemic and to reduce disparities in healthcare and health outcomes. 1", "keywords": [ "Address", "Admission activity", "Adult", "Adverse effects", "Affect", "Alzheimer&apos", "s disease related dementia", "Area", "COVID-19", "COVID-19 pandemic", "COVID-19 pandemic effects", "COVID-19 patient", "COVID-19 vaccination", "Caring", "Cognitive", "County", "Data", "Dementia", "Distance Learning", "Economics", "Ethnic Origin", "Event", "Exposure to", "Family", "Family member", "Gender", "Geographic Locations", "Geography", "Grain", "Health", "Health Care Costs", "Health Policy", "Healthcare", "Healthcare Systems", "Home Care Services", "Home Nursing Care", "Hospitalization", "Hospitals", "Individual", "Job loss", "Measures", "Mediating", "Nursing Homes", "Outcome", "Persons", "Physical Function", "Policies", "Race", "Resources", "Risk", "Role", "Time", "Variant", "Virus", "Virus Diseases", "care systems", "cognitive function", "disparity reduction", "ethnic minority", "experience", "health care disparity", "health care service utilization", "health difference", "improved", "in-home care", "infection rate", "infection risk", "informal care", "innovation", "insight", "intervention program", "long term consequences of COVID-19", "mortality", "pandemic disease", "pandemic impact", "pre-pandemic", "primary caregiver", "racial minority", "social", "sociodemographics", "socioeconomics" ], "approved": true } }, { "type": "Grant", "id": "11788", "attributes": { "award_id": "5R01NR020482-02", "title": "Leveraging community-based behavioral health to increase vaccine uptake in Latinx adults with mental illness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 6234, "first_name": "Dionne", "last_name": "Godette", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-26", "end_date": "2027-06-30", "award_amount": 548734, "principal_investigator": { "id": 26545, "first_name": "Rocio", "last_name": "Calvo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26546, "first_name": "Kirsten", "last_name": "Davison", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26547, "first_name": "SEBASTIEN", "last_name": "HANEUSE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 425, "ror": "https://ror.org/02n2fzt79", "name": "Boston College", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Latinxs, particularly those with mental illness, are at higher risk of COVID-19 infection, and associated morbidity and mortality, and yet have lower rates of vaccination, than non-Latinx whites. This pattern is not unique to COVID-19; it has been observed for other infectious diseases, including seasonal influenza. Vaccine hesitancy, understood as a delay in the acceptance of vaccination despite availability of vaccination services, is the primary roadblock for COVID-19 and influenza vaccination among Latinxs. Theoretical frameworks endorsed by the SAGE working group on vaccine hesitancy, and prior research, illustrate that interventions to reduce vaccine hesitancy and increase vaccine uptake in Latinxs should adopt strategies that: increase vaccine confidence and convenience; reduce vaccine complacency; and respond to contextual, individual and vaccine-related factors driving hesitancy, which include but are not limited to the social determinants of health and structural racism. While a variety of strategies have been developed to address vaccine hesitancy in priority populations, the potential role of behavioral health in community-based integrated health care settings has been overlooked. Yet behavioral health, particularly within federally qualified health centers (FQHCs) which target social determinants of health, may be an ideal setting to reach Latinxs, and other priority populations with mental illness, to address vaccine hesitancy and promote vaccine uptake. In collaboration with East Boston Neighborhood Health Center (EBNHC), the largest FQHC of Massachusetts, the proposed study will evaluate a novel Motivational Interviewing (MI) behavioral intervention to reduce vaccine hesitancy and increase COVID-19 and influenza vaccine uptake in Latinx adults with mental illness. Key to the intervention is that the proposed MI protocol explicitly acknowledges cultural values that are central to the Latinx population and that impact their interactions with health care providers. Additionally, the intervention has been specifically designed to be feasible and readily implemented in community-based settings, and to be sustainable in the long-term regardless of how the rapidly changing COVID-19 vaccination landscape evolves. To rigorously evaluate the intervention, we will conduct a pragmatic multiple-period cluster-randomized crossover trial within four BH programs at EBNHC; key to this design is that each program serves as its own control and that the multiple switches enhance statistical power. To our knowledge, this will be the first study to rigorously examine the potential role of BH providers in increasing vaccine uptake among Latinx adults with mental illness, a particularly vulnerable population. Key to the anticipated impact is the partnership between the academia-based research team and colleagues at EBNHC which, in turn, will support the rapid translation of evidence into practice together with a model for sustainable collaboration and national scaleup.", "keywords": [ "Academia", "Address", "Adopted", "Adult", "Automobile Driving", "Behavior Therapy", "Boston", "COVID-19", "COVID-19 morbidity", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Caring", "Collaborations", "Communicable Diseases", "Communities", "Counseling", "Country", "Coupled", "Cross-Over Trials", "Death Rate", "Development", "Diagnosis", "Discrimination", "Electronics", "Elements", "Federally Qualified Health Center", "Health Personnel", "Health Services", "Hispanic", "Individual", "Influenza vaccination", "Intervention", "Knowledge", "Language", "Latinx", "Latinx population", "Leadership", "Massachusetts", "Mental Health", "Mental disorders", "Modeling", "Morbidity - disease rate", "Neighborhood Health Center", "Neighborhoods", "Pathway interactions", "Patients", "Pattern", "Population", "Positioning Attribute", "Protocols documentation", "Provider", "Randomized", "Research", "Research Personnel", "Risk", "Role", "SARS-CoV-2 infection", "Safety", "Series", "Services", "Structural Racism", "Time", "Training", "Translations", "Trauma", "Trust", "Universities", "Vaccinated", "Vaccination", "Vaccines", "Vulnerable Populations", "World Health Organization", "behavioral health", "behavioral health intervention", "booster vaccine", "clinical practice", "college", "cultural values", "design", "effectiveness evaluation", "effectiveness testing", "evidence base", "experience", "global health", "health care settings", "health disparity", "high risk", "hospitalization rates", "influenza virus vaccine", "innovation", "integrated care", "intervention effect", "mortality", "motivational enhancement therapy", "novel", "pandemic disease", "person centered", "point of care", "programs", "response", "scale up", "seasonal influenza", "social health determinants", "theories", "treatment as usual", "trial design", "uptake", "vaccine acceptance", "vaccine access", "vaccine distribution", "vaccine hesitancy", "vaccine refusal", "working group" ], "approved": true } }, { "type": "Grant", "id": "11789", "attributes": { "award_id": "5R01DA054910-02", "title": "Life Stress Pathways and Resilience to Substance Misuse in Black and White Youth", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10174, "first_name": "Sheba King", "last_name": "Dunston", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2027-06-30", "award_amount": 641851, "principal_investigator": { "id": 26297, "first_name": "Karen J", "last_name": "Derefinko", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 847, "ror": "", "name": "UNIVERSITY OF TENNESSEE HEALTH SCI CTR", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "Exposure to life stressors across development is known to increase the likelihood of adolescent substance misuse, but the few available comparisons of Black and White youth have revealed a paradox. Whereas Black youth are more likely than White youth to experience stressors in the form of socioeconomic disadvantage, traumatic events, and discrimination, often within a context of structural racism, studies show they have lower rates of nearly all types of substance misuse. This paradox could have health consequences, for example, by contributing to stigma among Black individuals who do struggle with substance misuse, because the adverse consequences of substance misuse, once initiated, are more severe for Blacks than Whites. However, significant gaps in knowledge exist and will be addressed in the proposed study. Little is known about how the different types, timing, and trajectories of stress exposures, including those associated with the ongoing COVID-19 pandemic, may differentially predict substance misuse for Black and White youth (Aim 1), and potentially through different mediating mechanisms (Aim 2), including parenting, neurocognitive functioning, and psychopathology. Also, it is important to understand the resilience-promoting protective factors that may be stronger buffers against stressor-related risk for substance misuse for Blacks than Whites (Aim 3). This application proposes to extend the ongoing CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood) study. CANDLE is a longitudinal cohort study involving 1,136 women recruited from 2006-2011 in Shelby County/Memphis, TN during their second trimesters of pregnancy, and has followed them and their children upon birth throughout childhood. The sample is 60% Black and 34% White, with the small balance reflecting other racial/ethnic minority groups. Extensive multi-method data have been collected during the prenatal period and through childhood up to age 8 years. A clinic visit with dyads at child age 10 is nearing completion and another funded clinic visit at age 12 is underway. The proposed research will collect new data in adolescence at ages 14, 15, and 16 years to examine life stressors in relation to the onset and progression of substance misuse for Black compared to White youth, with tests of differences as well as similarities in mediating pathways and resilience factors. Sex differences also will be explored. A local advisory board of Black community members and advocates has already been formed and will help guide this study. Guided by the minority stress model and stress-coping theories of addiction, the central hypotheses are that, despite a Black-White paradox, different patterns of life stress exposures will predict substance misuse for both Black and White youth, operating through selected group-specific mediating mechanisms; based on resiliency theory, Black youth also are expected to display certain unique patterns of resilience against substance misuse. CANDLE is one-of-a-kind, and the current aims hold promise for informing tailored preventive efforts.", "keywords": [ "8 year old", "Address", "Adolescence", "Adolescent", "Advocate", "Affect", "Age", "Alcohols", "Birth", "Black Populations", "Black race", "Buffers", "COVID-19 impact", "COVID-19 pandemic", "Child", "Child Rearing", "Childhood", "Cigarette", "Clinic Visits", "Communities", "County", "Data", "Development", "Discrimination", "Electronic cigarette", "Equilibrium", "Exposure to", "Funding", "Goals", "Health", "Home visitation", "Illicit Drugs", "Intervention", "Interview", "Knowledge", "Learning", "Life", "Life Stress", "Link", "Longitudinal cohort study", "Marijuana", "Mediating", "Methods", "Mission", "Modeling", "National Institute of Drug Abuse", "Neurocognitive", "Parents", "Pathway interactions", "Pattern", "Prevention", "Prevention approach", "Preventive", "Psychopathology", "Public Health", "Questionnaires", "Reduce health disparities", "Research", "Research Methodology", "Risk", "Sampling", "Second Pregnancy Trimester", "Sex Differences", "Social support", "Stress", "Stress and Coping", "Structural Racism", "Subgroup", "Testing", "Time", "United States National Institutes of Health", "Woman", "Work", "Youth", "addiction", "adverse outcome", "alcohol use initiation", "behavior observation", "comparison group", "early childhood", "early life stress", "ethnic minority population", "experience", "longitudinal design", "member", "minority stress", "next generation", "prenatal", "prenatal exposure", "preventive intervention", "protective factors", "racial minority population", "recruit", "resilience", "social stigma", "socioeconomic disadvantage", "stressor", "substance misuse", "theories", "traumatic event" ], "approved": true } }, { "type": "Grant", "id": "11790", "attributes": { "award_id": "5R01NR020854-02", "title": "Housing Policies and their Impact on Engagement in Substance Use Treatment and Overdose Risk during the COVID-19 Pandemic", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 6234, "first_name": "Dionne", "last_name": "Godette", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-26", "end_date": "2026-06-30", "award_amount": 758283, "principal_investigator": { "id": 24388, "first_name": "Matthew", "last_name": "Eisenberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22921, "first_name": "Craig Evan", "last_name": "Pollack", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Substance use disorder (SUD), overdose risk, and housing insecurity have reached crisis levels in the US. In 2019, over 8 million individuals met criteria for SUD, and nearly 37 million households were spending more than 30% of their income on housing. Since the start of the COVID-19 pandemic, already-high overdose mortality rates soared, and millions of households have fallen behind on their rent. Beyond initiatives focused on people without housing such as housing first, there has been a paucity of research focusing on the intersection of SUD and housing insecurity. Even less is known about whether policy attempts designed to support housing security have the potential to improve engagement in substance use treatment and reduce fatal and non-fatal overdose. Innovative housing policies enacted during the COVID-19 pandemic—including eviction moratoriums, emergency rental assistance, and legal representation to tenants facing eviction (right to counsel)—offer an unprecedented opportunity to fill this vital knowledge gap. Widespread variation across states in whether and how these policies were implemented allow them to be rigorously studied using causal methods with mechanisms and potential mechanisms explored using qualitative approaches. In Aims 1-2, we will conduct a 50-state study using a difference-in-differences approach to examine the effects of the three housing policies of interest on rates of substance use treatment and fatal and non-fatal drug overdose. Data sources for Aims 1-2 will include 50-state administrative databases capturing services delivered in the general medical sector (IQVIA LRx/Dx and HCUP) and specialty addiction treatment sector (TEDS), as well as CDC fatal drug overdose data. In Aim 3, we will conduct in-depth qualitative interviews with people with recent histories of drug use as well as providers and policy officials in urban and rural counties. Our study will yield actionable evidence to inform policy development and implementation at the intersection of housing and SUD designed to enhance engagement in addiction treatment and prevent drug overdose.", "keywords": [ "Accident and Emergency department", "Achievement", "Address", "Affect", "Ambulatory Care", "Behavioral", "Buprenorphine", "COVID-19", "COVID-19 impact", "COVID-19 pandemic", "Centers for Disease Control and Prevention (U.S.)", "Color", "Communities", "Costs and Benefits", "Counseling", "Data", "Data Sources", "Delaware", "Drug usage", "Emergency Situation", "Ensure", "Epidemiology", "Ethnic Origin", "FDA approved", "Fatality rate", "Funding", "Health Care Costs", "Health Services Research", "Household", "Housing", "Income", "Individual", "Inpatients", "Intervention", "Interview", "Knowledge", "Legal", "Life", "Life Expectancy", "Maryland", "Measures", "Medical", "Methadone", "Methods", "Naltrexone", "Outcome", "Overdose", "Pennsylvania", "Persons", "Pharmaceutical Preparations", "Pharmacologic Substance", "Policies", "Policy Developments", "Policy Maker", "Policy Research", "Population", "Provider", "Qualitative Methods", "Race", "Recording of previous events", "Recovery", "Research", "Risk", "Security", "Services", "Speed", "Structural Racism", "Structure", "Substance Use Disorder", "Time", "Variant", "West Virginia", "addiction", "administrative database", "design", "evidence base", "experience", "falls", "health economics", "health service use", "improved", "innovation", "interest", "medical specialties", "mortality", "opioid use disorder", "overdose death", "overdose risk", "pandemic disease", "population based", "post-pandemic", "prevent", "psychiatric comorbidity", "public health emergency", "relapse risk", "rural counties", "service programs", "service providers", "substance use", "substance use treatment", "supported housing", "treatment and outcome", "treatment risk", "treatment services" ], "approved": true } } ], "meta": { "pagination": { "page": 1392, "pages": 1392, "count": 13920 } } }