Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1392&sort=-other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-other_investigators", "next": null, "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1391&sort=-other_investigators" }, "data": [ { "type": "Grant", "id": "10695", "attributes": { "award_id": "1I21RX004092-01A1", "title": "Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-10-01", "end_date": "2024-09-30", "award_amount": null, "principal_investigator": { "id": 26752, "first_name": "Marianne", "last_name": "Goodman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1533, "ror": "", "name": "JAMES J PETERS VA MEDICAL CENTER", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "At present, 34.6 million people in the United States, and 273,232 Veterans tested or treated in Veteran Affairs facilities contracted COVID-19. While the exact prevalence of Post-Acute COVID-19 Syndrome (PACS) among Veterans is unknown, estimates of psychiatric/neurological PACS using a large global sample of COVID-19 patients (N=236,379) suggest a prevalence of approximately 11,390,400 Americans, and 90,311 Veterans in VA care, with rates likely to increase over time. Moreover, large scale studies suggest up to 35% of individuals experience functional impairment 8 months after COVID-19, and high prevalence of post-infection mental illness including anxiety disorders, depression, and post-traumatic stress disorder. Using longitudinal data from our academic affiliate, Icahn School of Medicine at Mount Sinai’s COVID registry (n≈1200), and local James J. Peters VA’s Clinical PACS program, coupled with our expertise in recovery-based psychotherapy, we are uniquely poised to develop an innovative treatment for Veterans struggling with PACS. Our intervention aims to improve psychological adjustment to PACS symptoms, promote resiliency, and facilitate coping, all of which can impact functional status and quality of life. The PACS-Coping and Recovery (PACS-CR) intervention we aim to develop focuses on psychological adjustment and coping, and augments medical, rehabilitative and neurological treatment for this population. Our approach is based on the CHIME model of personal recovery which includes five overarching processes: 1) Connectedness; 2) Hope and optimism about the future; 3) Identity; 4) Meaning in life; and 5) Empowerment. We will target the CHIME processes using established psychotherapeutic techniques such as skills training, acceptance-based and identity-based principles. Based on adaptations from existing recovery-based and COVID-19 distress group interventions that our team has developed and piloted, we are proposing a treatment framework that consists of a core of twelve 90-minutes sessions (1x/week x 12 weeks) with additional weekly sessions on specialized topics that are optional. We are proposing a treatment development NIH Stage 1A study to develop a Post-Acute COVID-19 Syndrome psychotherapeutic intervention, “PACS Coping and Recovery” (PACS-CR) through an iterative development process while collecting pilot data to assess its acceptability and feasibility. Our treatment development SPiRE will focus on 1) determining the treatment needs of Veterans with PACS, 2) developing the treatment using pilot qualitative data and aided by stakeholder feedback, 3) refining the intervention by three iterative pilots of our groups, testing both in person and telehealth versions. Pre and post measures will be utilized to track functional improvement and the degree to which this recovery-focused intervention has enabled the veterans to engage in meaningful life changes.", "keywords": [ "Activities of Daily Living", "Acute", "Address", "American", "Anxiety", "Anxiety Disorders", "Arthralgia", "COVID-19", "COVID-19 patient", "Cardiovascular system", "Caring", "Chronic", "Climacteric", "Clinical", "Consultations", "Contracts", "Coping Skills", "Coupled", "Data", "Development", "Disease", "Distress", "Education", "Employment", "Epidemiology", "Fatigue", "Feedback", "Fostering", "Future", "Goals", "Headache", "Health", "High Prevalence", "Impairment", "Individual", "Infection", "Intervention", "Interview", "Knowledge", "Leadership", "Life", "Life Style", "Loneliness", "Long COVID", "Longitudinal Studies", "Measures", "Medical", "Memory impairment", "Mental Depression", "Mental Health", "Mental disorders", "Modeling", "Needs Assessment", "Neurologic", "Neurologic Symptoms", "Nutritionist", "Pain", "Pain Disorder", "Participant", "Patients", "Persons", "Phase", "Population", "Post-Traumatic Stress Disorders", "Prevalence", "Process", "Protocols documentation", "Provider", "Psychological adjustment", "Psychotherapy", "Quality of life", "Recovery", "Registries", "Rehabilitation therapy", "Sampling", "Services", "Sleep Disorders", "Sleeplessness", "Specialist", "Symptoms", "Techniques", "Testing", "Time", "United States", "United States Department of Veterans Affairs", "United States National Institutes of Health", "Veterans", "acceptability and feasibility", "arm", "base", "cohort", "common symptom", "coping", "coronavirus disease", "design", "disorder later incidence prevention", "empowerment", "experience", "fitness", "flexibility", "follow-up", "functional disability", "functional improvement", "functional status", "group intervention", "health assessment", "improved", "innovation", "interdisciplinary approach", "medical schools", "neurological rehabilitation", "novel", "optimism", "physical conditioning", "post SARS-CoV-2 infection", "programs", "psychosocial", "pulmonary symptom", "rehabilitation strategy", "resilience", "satisfaction", "skills", "skills training", "sleep health", "symptomatology", "telehealth", "therapy development" ], "approved": true } }, { "type": "Grant", "id": "10698", "attributes": { "award_id": "1U01MD018310-01", "title": "Faithful Response II: COVID-19 Rapid Test-to-Treat with African American Churches", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 6025, "first_name": "Crystal", "last_name": "Barksdale", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-11-01", "end_date": "2024-10-31", "award_amount": 1016780, "principal_investigator": { "id": 6100, "first_name": "Jannette Yvonne", "last_name": "Berkley-Patton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 753, "ror": "", "name": "UNIVERSITY OF MISSOURI KANSAS CITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 753, "ror": "", "name": "UNIVERSITY OF MISSOURI KANSAS CITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "10700", "attributes": { "award_id": "75N93021D00035-0-759302200002-1", "title": "Completion of ACTIV-2 Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-11-06", "end_date": "2024-10-31", "award_amount": 82531927, "principal_investigator": { "id": 26756, "first_name": "ANGEE", "last_name": "GREER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1807, "ror": "", "name": "PPD, INC.", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "NIAID is sponsoring a clinical research study on novel therapeutics for COVID-19, which is one of the clinical studies for Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV). With an existing clinical trial infrastructure and multiple support contracts to provide services related to clinical trials support, regulatory support and pharmacy support, NIAID serves as the sponsor for the COVID-19 clinical trial entitled “A5401: Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID)” also known as ACTIV-2. The objective of ACTIV-2 is to evaluate the safety and efficacy of multiple investigational agents aimed at modifying the host immune response to SARS-CoV-2 infection, or directly enhancing viral control in order to limit disease progression.", "keywords": [ "COVID-19", "COVID-19 therapeutics", "Clinical Research", "Clinical Trials", "Disease Progression", "Immune response", "Infrastructure", "Investigation", "National Institute of Allergy and Infectious Disease", "Outpatients", "Pharmacy facility", "Reporting", "SARS-CoV-2 infection", "Safety", "Services", "Support Contracts", "Therapeutic Intervention", "Viral", "coronavirus disease", "novel therapeutics", "research study", "therapeutic vaccine", "treatment trial" ], "approved": true } }, { "type": "Grant", "id": "10702", "attributes": { "award_id": "5P20GM109091-09", "title": "Synthesis of cannabidiol dimers as potential agents to treat neurological disorders", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 6278, "first_name": "FEDERICO", "last_name": "Bernal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-11-08", "end_date": "2024-04-30", "award_amount": 223500, "principal_investigator": { "id": 26757, "first_name": "Francisco", "last_name": "Leon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 930, "ror": "", "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID pandemic has worsened stress, anxiety, and depression in the US population. Current FDA approved therapeutics for these ailments are only effective in subpopulations, and it is very common for patients to have to attempt multiple regimens to find one that works. Not surprisingly, patients continue seeking alternative remedies for self-treatment, e.g., cannabis. However, regardless of the legalization of cannabis in many states and its widespread usage for these purposes, cannabis is a diverse mixture of hundreds of compounds that widely vary in amount depending on the cannabis source. One active component of cannabis, cannabidiol (CBD), has been individually studied for its medicinal activity. Epidiolex®, a highly purified form of CBD, is FDA approved to treat rare forms of epilepsy. The issue is that CBD – in its natural form – is a non-specific (poly-pharmacological) agent. CBD weakly activates several receptors of the following classes: cannabinoid, opioid, serotonin (5-HT1A, 5-HT2A), orphan-GPR55, adenosine, and TRP receptors, among others. It remains unclear which receptor(s) and signaling pathway(s) are crucial for the positive benefits of CBD. Our long-term goal is to identify and expand novel therapeutics with defined, specific mechanisms of action for neurological/mental disorders. In this light, the overall objective in this application is to create novel CBD dimers that are proposed to be specific to cannabinoid or serotonin receptors. We will assess the hypothesis that CBD homo/heterodimers will enhance the selective binding to cannabinoid and serotonin receptors through bivalent or bitopic binding on dimerreceptors or a single receptor on two sites, respectively. Upon generation of our CBD homo/heterodimer library, we will evaluate their selectivity for the above receptors, and we will also evaluate dimers in a psychoactive receptor panel (NIMH-PDSP). This will position us to build key preliminary data for a competitive NIH application. Development of these novel dimers as chemical biology probes will elucidate the interactions of CBD with serotonin and cannabinoid receptors and the structural details behind these activities. Ultimately, these CBD semisynthetic derivatives have the potential to yield favorable therapeutic indices for the treatment of stress, anxiety, and depression. Results consistent with our hypothesis will have wide-ranging public health implications because of societal interest in CBD despite its poorly understood activities and because of the urgent need for safe, effective therapies. Importantly, if successful, the long-term goal is to move promising compounds into advanced preclinical testing.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10704", "attributes": { "award_id": "1U01MD018316-01", "title": "Evaluating a Community-Led COVID-19 Testing Intervention to Address Mistrust", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 6029, "first_name": "JARRETT AINSWORTH", "last_name": "Johnson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-11-01", "end_date": "2024-10-31", "award_amount": 525000, "principal_investigator": { "id": 24940, "first_name": "Andrew Duane", "last_name": "Plunk", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1806, "ror": "https://ror.org/056hr4255", "name": "Eastern Virginia Medical School", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1806, "ror": "https://ror.org/056hr4255", "name": "Eastern Virginia Medical School", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "10705", "attributes": { "award_id": "1U01MD018306-01", "title": "Leveraging artificial intelligence and social innovation to reduce disparities in COVID-19 testing among African Americans", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 6029, "first_name": "JARRETT AINSWORTH", "last_name": "Johnson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-11-01", "end_date": "2024-10-31", "award_amount": 555475, "principal_investigator": { "id": 20638, "first_name": "Tiarney D", "last_name": "Ritchwood", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 246, "ror": "https://ror.org/00py81415", "name": "Duke University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 246, "ror": "https://ror.org/00py81415", "name": "Duke University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "10708", "attributes": { "award_id": "1R21AI168523-01A1", "title": "Transcriptional regulation of ACE2 and the adaption of SARS-CoV-2", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 26420, "first_name": "MARY KATHERINE", "last_name": "Bradford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-11-11", "end_date": "2024-10-31", "award_amount": 231000, "principal_investigator": { "id": 26761, "first_name": "Yiping", "last_name": "Zhu", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 464, "ror": "https://ror.org/022kthw22", "name": "University of Rochester", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "10711", "attributes": { "award_id": "1F32MD017452-01", "title": "Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6121, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-12-01", "end_date": "2025-11-30", "award_amount": 71290, "principal_investigator": { "id": 26764, "first_name": "Ariel L", "last_name": "Beccia", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 798, "ror": "https://ror.org/00dvg7y05", "name": "Boston Children's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "PA-21-048 Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship, NOT-MD- 19-001 (Notice of Special Interest in Research on the Health of Sexual and Gender Minority (SGM) Populations): The coronavirus disease 2019 (COVID-19) pandemic has had a profound negative impact on population mental health in the United States, especially for marginalized populations such as sexual minorities (SMs). Emerging research suggests that this disparity is driven by minority stress processes (e.g., stigma) and structural vulnerabilities (e.g., institutional oppression) that systematically expose SMs to more pandemic-related stressors and exacerbate their effects. However, critical knowledge gaps remain regarding the intersectional distribution and upstream (i.e., social and structural) determinants of COVID-19-related disparities in mental health. To address these gaps, the current project will draw on minority stress, intersectionality, and ecosocial frameworks to examine how multiple dimensions of social identity/position and upstream pandemic-related stressors have jointly impacted population mental health for SMs over the course of the pandemic. Leveraging unprecedented data from the COVID-19 Pandemic Sub-Study (a population-based longitudinal cohort study embedded within the Nurses’ Health Study 2 & 3 and the Growing Up Today Study with N>57,000) and novel analytic methods from social, spatial, and legal epidemiology, the project aims are to: 1) estimate the time-varying prevalence of mental health symptoms (i.e., depressive, anxiety, and eating disorder symptomology) over the first year of the COVID-19 pandemic across groups jointly defined by sexual orientation, gender, and race/ethnicity; 2) evaluate whether the prevalence patterns observed in Aim 1 are related to the spatiotemporal distribution characteristics of COVID-19 morbidity and mortality (e.g., county-level mortality rate); and 3) evaluate whether the prevalence patterns observed in Aim 1 are related to the broader pandemic policy environment (e.g., lockdowns/stay-at- home orders, with or without concomitant economic relief efforts). These aims are consistent with the stated priorities in the NIH FY 2021–25 Strategic Plan to Advance Research on the Health & Well-Being of Sexual & Gender Minorities, and importantly, are of urgent relevance to public health. Ultimately, the proposed project will provide a more nuanced and contextualized understanding of SM mental health during the ongoing COVID-19 pandemic, with the intent of generating knowledge that can inform the development and implementation of much- needed mental health equity efforts. A tailored mentored training plan accompanies this proposal and outlines the steps required to advance the Applicant’s career as an independent investigator with expertise in conducting methodologically-rigorous and theoretically-informed SM mental health disparities research.", "keywords": [ "Address", "Affect", "Anxiety Disorders", "COVID-19", "COVID-19 disparity", "COVID-19 morbidity", "COVID-19 mortality", "COVID-19 pandemic", "Characteristics", "County", "Data", "Data Sources", "Depressive disorder", "Development", "Dimensions", "Distress", "Eating Disorders", "Economic Policy", "Economics", "Environment", "Epidemiologic Methods", "Epidemiology", "Ethnic Origin", "Fellowship", "Financial Hardship", "Fright", "Gender", "Goals", "Health", "Health Disparities Research", "Heterosexuals", "Home", "Individual", "Individual National Research Service Award", "Infection", "Intervention", "Knowledge", "Legal", "Life", "Longitudinal cohort study", "Mental Depression", "Mental Health", "Mentors", "Mentorship", "Methodology", "Methods", "Minority", "Modeling", "National Institute on Minority Health and Health Disparities", "Nurses&apos", "Health Study", "Pattern", "Personal Satisfaction", "Policies", "Population", "Positioning Attribute", "Prevalence", "Process", "Psychopathology", "Public Health", "Race", "Reporting", "Research", "Research Personnel", "Risk", "Sex Orientation", "Sexual Health", "Sexual and Gender Minorities", "Shapes", "Social Identification", "Strategic Planning", "Stress", "Subgroup", "Symptoms", "Time", "Training", "United States", "United States National Institutes of Health", "Work", "analytical method", "career", "cohort", "epidemiology study", "ethnic identity", "experience", "gender minority group", "health disparity", "health equity", "high risk", "innovation", "interest", "intersectionality", "lens", "marginalized population", "minority stress", "mortality", "multidimensional data", "multilevel analysis", "novel", "pandemic disease", "population based", "psychological distress", "racial and ethnic", "sexual minority", "sexual minority health", "skills", "social", "social stigma", "social structure", "spatiotemporal", "stressor", "transmission process" ], "approved": true } }, { "type": "Grant", "id": "10712", "attributes": { "award_id": "1I21RX004396-01", "title": "Predictors of Post-COVID Clinical and Cognitive Consequences", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-12-01", "end_date": "2024-11-30", "award_amount": null, "principal_investigator": { "id": 26765, "first_name": "Susmita", "last_name": "Chowdhuri", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1960, "ror": "", "name": "JOHN D DINGELL VA MEDICAL CENTER", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Patients recovering from acute COVID-19 infection often suffer from a multitude of debilitating chronic physical symptoms that can last up to 6 months or more. The incidence of fatigue, cognitive impairment and respiratory symptoms are reported to be very high in the post-COVID period. The underlying pathophysiology of cognitive impairment is unclear in these patients. Notably, sleep disturbances are common during this post-COVID period, and sleep apnea has been associated with an increased risk for severe COVID infection. Thus, it is conceivable that sleep fragmentation, per se, may confer an increased risk for chronic cognitive deficits in Veterans post-COVID. Our proposed pilot project will determine if there is a link between post-COVID sleep disturbances, sleep apnea and cognitive function. Knowledge gained from our examinations may guide development of novel management pathways, i.e., mitigation of sleep disturbances may present a therapeutic strategy for alleviating chronic post-COVID cognitive impairment. Aim1 will investigate the effect of sleep duration and sleep quality on neurocognitive function in post-COVID Veterans. Aim 2 will study whether the severity of OSA determines neurocognitive function Veterans who are post-COVID. This is an observational study where we will gather retrospective as well as prospective data on the long-term effects of COVID on neurocognitive function and sleep. Our long-term goal is to enhance rehabilitation and recovery of function of Veterans suffering from post-COVID consequences that may arise due to sleep disturbances, with the ultimate objective of improving the overall health and quality of life of Veterans recovering from COVID-19 infection.", "keywords": [ "Acute", "Address", "Adverse effects", "Alleles", "Alzheimer&apos", "s Disease", "Apolipoprotein E", "Area", "Blood Coagulation Disorders", "COVID-19", "COVID-19 complications", "COVID-19 cytokine storm", "COVID-19 impact", "COVID-19 severity", "Centers for Disease Control and Prevention (U.S.)", "Chronic", "Clinical", "Cognitive", "Cognitive deficits", "Complex", "Cough Headaches", "Data", "Development", "Diagnostic", "Disease", "Dyspnea", "Encephalopathies", "Fatigue", "Functional disorder", "Future", "Genes", "Goals", "Health", "Healthcare", "Hour", "Hypoxia", "Impaired cognition", "Impairment", "Incidence", "Infection", "Inflammation", "Interleukin-6", "Knowledge", "Link", "Long COVID", "Long-Term Effects", "Memory impairment", "Mental Health", "Neurocognitive", "Neurocognitive Deficit", "Neurologic", "Neutrophilia", "Observational Study", "Obstructive Sleep Apnea", "Pathway interactions", "Patients", "Pilot Projects", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Quality of life", "Recovery", "Recovery of Function", "Rehabilitation therapy", "Reporting", "Research", "Respiratory Signs and Symptoms", "Risk", "SARS-CoV-2 infection", "Severities", "Sleep", "Sleep Apnea Syndromes", "Sleep Deprivation", "Sleep Fragmentations", "Sleep disturbances", "Symptoms", "TNF gene", "Testing", "Therapeutic", "Veterans", "Virus", "Visit", "acute infection", "brain fog", "cognitive function", "coronavirus disease", "cytokine", "disability", "factor A", "improved", "inflammatory marker", "novel", "physical conditioning", "physical symptom", "poor sleep", "post SARS-CoV-2 infection", "post-COVID-19", "prospective", "research study", "respiratory", "response", "severe COVID-19", "sleep quality", "therapeutic target", "trait" ], "approved": true } }, { "type": "Grant", "id": "10714", "attributes": { "award_id": "1R01AG080483-01", "title": "Addressing the Midlife Mortality Crisis: Place-Based Modeling, Trend Analysis and Policy Interventions", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 9723, "first_name": "AMELIA WILKES", "last_name": "Karraker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-12-01", "end_date": "2026-11-30", "award_amount": 581239, "principal_investigator": { "id": 26767, "first_name": "Myron P.", "last_name": "Gutmann", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1583, "ror": "", "name": "UNIVERSITY OF COLORADO", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will study midlife mortality trends by analyzing the local correlates and risk factors of cause of death in their place-based context between 1990 and 2021. Using cause-specific death data, sociodemo- graphic characteristics, and economic trends, the research will generate trajectories of midlife mortality risks for dynamically-derived spatial units. What makes this project innovative and significant is (1) mortality data at the block, zip code or tract level; (2) methods in spatial analysis, time series trajectory determination, and mul- tiscalar statistical analysis; and (3) an innovative and integrated approach to policy research, conducted by a team experienced in demographic analysis, multiscalar spatial and temporal statistics, and rural health policy formulation. This work responds to research and policy discussions regarding potentially-modifiable attributes of places related to rising mortality among middle-aged adults. Several cause-specific mortality trends warrant attention: rising rates of suicides, cardiometabolic diseases, and deaths due to drug or alcohol abuse, along with their interactions with select infectious diseases (e.g., Hepatitis C and COVID-19). The project has five specific aims: (1) For select U.S. states where block- or tract-level mortality data are available, researchers will create a novel micro-scale database with cause-specific mortality records and contextual data including cen- sus-based demographic data, employment and business data, property characteristics, and crime data. (2) The research makes use of an iterative algorithm to identify clusters of micro-units that have common, cause- specific mortality patterns, using community detection methods, in order to identify the most salient levels of spatial units at which processes affecting midlife mortality occur. It also assesses spatial autocorrelation to identify mortality hot- and cold-spots (spatial) and undertakes extreme event detection to identify hot-moments (temporal). (3) The project uses multi-channel sequencing to classify geographic units, for example, where population has grown or diminished, aged, or seen an increase in children, or where the economy has created wealth. These trajectories constitute a set of place-based classifications for later analysis. (4) The project’s analysis will use spatiotemporal models to estimate the effect of local-to-regional determinants of cause-spe- cific mortality in middle-aged adults, with two strategies: (A) Assess the role of different place-based determi- nants of midlife mortality, in order to evaluate theories of midlife mortality differentials and to test specific hy- potheses (e.g., economic distress). (B) Identify the optimal scale at which determinants with the greatest im- pact operate to inform policy recommendations designed to target midlife mortality for specific causes of death. (5) Designing policy interventions is fundamental to the project, which begins with a policy mapping process, and builds on the results of the multiscalar analysis to design intervention strategies targeting the determinants of mortality differentials and the characteristics of places at greatest risk of continued mortality challenges.", "keywords": [ "Address", "Adult", "Affect", "Age", "Alcohol abuse", "Algorithms", "Area", "Attention", "Businesses", "COVID-19", "Cardiometabolic Disease", "Cause of Death", "Censuses", "Cessation of life", "Characteristics", "Child", "Classification", "Code", "Communicable Diseases", "Communities", "Complex", "County", "Crime", "Data", "Databases", "Demographic Analyses", "Detection", "Development", "Differential Mortality", "Distress", "Drug abuse", "Economic Conditions", "Economics", "Employment", "Event", "Feedback", "Foreclosure", "Formulation", "Future", "Geography", "Health Policy", "Hepatitis C", "Housing", "Income", "Individual", "Inequality", "Intervention", "Methods", "Modeling", "Mortality Determinants", "Outcome", "Pattern", "Policies", "Policy Developments", "Policy Research", "Population", "Population Sizes", "Procedures", "Process", "Property", "Records", "Research", "Research Personnel", "Resolution", "Risk", "Risk Factors", "Role", "Rural", "Rural Health", "Science", "Series", "Social Conditions", "Spottings", "Statistical Data Interpretation", "Structure", "Testing", "Time", "Work", "aged", "base", "design", "detection method", "experience", "innovation", "middle age", "mortality", "mortality risk", "novel", "policy recommendation", "response", "social inequality", "spatiotemporal", "statistics", "suicide rate", "theories", "therapy design", "trend", "trend analysis" ], "approved": true } } ], "meta": { "pagination": { "page": 1392, "pages": 1392, "count": 13920 } } }