Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1392&sort=-approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=-approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1393&sort=-approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1391&sort=-approved" }, "data": [ { "type": "Grant", "id": "12165", "attributes": { "award_id": "7U01MH129968-03", "title": "The Impacts of County-Level COVID- 19 -Related Public Health and Social Policies on Racial/Ethnic and Socioeconomic Disparities in Mental Health and Healthcare Utilization", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 6350, "first_name": "Jennifer", "last_name": "Humensky", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-05", "end_date": "2026-07-31", "award_amount": 509205, "principal_investigator": { "id": 10475, "first_name": "Rita", "last_name": "Hamad", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 961, "ror": "", "name": "HARVARD SCHOOL OF PUBLIC HEALTH", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic and related mitigating measures have brought on tremendous financial hardship for vulnerable Americans, with nearly 15% unemployment at its peak and millions falling into poverty. There have been striking racial and socioeconomic disparities in these hardships, particularly for Black and Latinx families, which build on longstanding inequities in income, housing, and other social determinants of health. Recent research has demonstrated the impact of the pandemic and its resulting socioeconomic inequities on disparities in mental health and healthcare utilization. It is increasingly recognized that policies play a role in mitigating or exacerbating these disparities. For example, mandated closures lead to job and income loss, which disproportionately affect low-income and minority women. Conversely, economic support policies ensure that vulnerable families have the resources to stay healthy at home. While some studies have examined the effects of state-level COVID-19-related policies, there has been little systematic documentation of county-level policies and their effects on disadvantaged groups. The goal of this study is to leverage, expand upon, and link existing national data sets to test the hypothesis that county-level public health and social policies have affected disparities in mental health and healthcare utilization. In Aim 1, we will gather county-level COVID-19- related policy data for 2020-2021 for a nationwide sample of 250 counties, selected to ensure coverage of over half of the U.S. population as well as diversity in racial/ethnic, socioeconomic, and urban/rural composition. Policies will be drawn from online sources and grouped into 3 domains chosen due to likely impacts on mental health and utilization: (1) containment and closure, (2) economic support, and (3) public health. We will characterize geographic and temporal variation in county-level policies and make this database freely available. In Aim 2, we will examine which county-level COVID-19-related policies contributed to or ameliorated pandemic-related disparities in mental health and health behaviors, linking the policy database from Aim 1 with national health surveys that provide individual-level data on self-reported psychological distress, smoking, alcohol use, and illicit drug use. In Aim 3, we will estimate the association of county-level COVID-19-related policies with disparities in healthcare utilization for mental health problems, linking the policy database from Aim 1 with national data sets that provide individual-level data on healthcare utilization. Aims 2 and 3 exploit temporal and geographic variation in county-level policies and employ quasi-experimental methods to estimate policy effects. Conducted in close collaboration with other SBECCC investigators, the expected outcome of this research is the creation of a county-level policy database that will serve as a valuable resource for researchers and stakeholders working to understand how local policies contributed to and continue to influence pandemic- related health disparities, as well as specific evidence on policy effects on mental health outcomes. This will guide policies and interventions to reduce mental health burden especially for vulnerable communities.", "keywords": [ "Acute", "Address", "Adult", "Adverse effects", "Affect", "Alcohol consumption", "American", "Anxiety", "Behavioral Risk Factor Surveillance System", "Black race", "Businesses", "COVID-19", "COVID-19 pandemic", "Catalogs", "Collaborations", "Contact Tracing", "Containment", "County", "County Government", "Data", "Data Set", "Databases", "Disparity", "Disparity population", "Documentation", "Drug usage", "Economic Policy", "Economics", "Ensure", "Ethnic Origin", "Expenditure", "Experimental Models", "Family", "Financial Hardship", "Geography", "Goals", "Health", "Health Policy", "Health Services Accessibility", "Health Surveys", "Health behavior", "Home", "Household", "Housing", "Income", "Individual", "Inequity", "Intervention", "Job loss", "Latinx", "Lead", "Leadership", "Link", "Low Income Population", "Low income", "Measures", "Medicaid", "Medical", "Mental Depression", "Mental Health", "Mental Health Services", "Minority Women", "National Health Interview Survey", "Occupations", "Outcome", "Outcomes Research", "Patient Self-Report", "Persons", "Policies", "Policy Making", "Population", "Poverty", "Primary Care", "Public Health", "Quasi-experiment", "Race", "Reporting", "Research", "Research Personnel", "Resources", "Rural", "Sampling", "Services", "Smoking", "Social Policies", "Socioeconomic Status", "Source", "Stress", "Subgroup", "Surveys", "Testing", "Unemployment", "Vaccination", "Variant", "Vulnerable Populations", "Work", "behavioral health", "coronavirus disease", "ethnic disparity", "ethnic minority", "experience", "falls", "geographic difference", "health care disparity", "health care service utilization", "health disparity", "high risk population", "illicit drug use", "long-standing disparities", "medical specialties", "pandemic disease", "pandemic impact", "people of color", "psychological distress", "public health intervention", "racial disparity", "racial minority", "social determinants", "social health determinants", "socioeconomic disparity", "socioeconomics", "trend", "urban residence", "vulnerable community" ], "approved": true } }, { "type": "Grant", "id": "12166", "attributes": { "award_id": "1R44AI174405-01A1", "title": "A micronized electrostatic precipitator for next-generation respiratory protection against pathogenic aerosols", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 7856, "first_name": "Karen A.", "last_name": "Lacourciere", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-17", "end_date": "2025-07-31", "award_amount": 940026, "principal_investigator": { "id": 28031, "first_name": "Julian", "last_name": "Henley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2071, "ror": "", "name": "HENLEY ION, LLC", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "Many pathogens, such as severe acute respiratory coronavirus 2 (SARS-CoV-2) and Mycobacterium tuberculosis, spread via aerosol transmission and inflict global public health and economic consequences. SARS-CoV-2 has infected over 450 million people, led to over 6 million fatalities, and caused major economic losses. The tuberculosis-causing bacterium and longstanding global health enemy, M. tuberculosis, led to an estimated 1.3 million deaths and over 5 billion USD in global spending in 2020 alone. Both of these pathogens, SARS-CoV-2 and M. tuberculosis, impose disproportionate burdens on healthcare workers, who are exposed to airborne pathogens at higher rates than the general population. The current respiratory protection options available to healthcare workers are generally limited to surgical masks and nonoil-95 percent collection (N95) filter-based respirators. N95s are the current gold standard, but these respirators can only properly function when a snug seal on the face of the user causes a pressure drop, which makes breathing more difficult and often leads to compliance issues. These respirators are also not designed to inactivate the pathogens they collect, and their disposable nature generates waste and leaves users susceptible to supply shortages. Thus, the widespread threats of airborne pathogens and the significant limitations of existing protection options necessitate the development of novel strategies to protect healthcare workers from airborne transmission of infectious diseases. Henley Ion’s solution is a next-generation respirator based on a miniaturized form of an electrostatic precipitator (mEP). Henley Ion is the first to leverage the mEP strategy to remove aerosol particles in the context of personal respiratory protection. Rather than relying on a filter, this innovation allows Henley Ion to use mEP to capture and remove aerosol particles as the wearer breathes, needing only the natural velocity of normal breathing. In Aim 1, we will conduct benchtop testing to optimize device performance. We will demonstrate that the particle removal performance of our device matches or exceeds that of an N95 at a range of physiological respiration rates. In Aim 2, we will conduct biological testing to confirm optimized device performance that matches or exceeds the N95 for particle removal of SARS-CoV-2 and M. tuberculosis. We will measure particle removal at differential air flow rates and using discrete particle size distributions, and we will assess any residual viable pathogens in the device. Together, these steps will optimize the Henley mEP respirator and confirm its efficacy against both viral and bacterial pathogens, supporting the commercialization of this novel protective strategy to address the extreme need during the present pandemic and for infectious diseases more broadly.", "keywords": [ "2019-nCoV", "Address", "Aerosols", "Air", "Air Movements", "Bacteria", "Biological Assay", "Biological Testing", "Breathing", "COVID-19", "COVID-19 pandemic", "Cessation of life", "Charge", "Collection", "Communicable Diseases", "Development", "Device or Instrument Development", "Devices", "Drops", "Economics", "Effectiveness", "Electronics", "Electrons", "Electrostatics", "Engineering", "Ensure", "Equipment", "Excision", "Exposure to", "Face", "Filtration", "Frontline worker", "Future", "General Population", "Generations", "Goals", "Health Personnel", "Health care facility", "Health protection", "Hour", "Human", "Ions", "Laboratories", "Masks", "Measures", "Medical Device", "Methods", "Microprocessor", "Mycobacterium tuberculosis", "Nature", "Ozone", "Particle Size", "Pathogenicity", "Penetration", "Performance", "Persons", "Phase", "Physiological", "Precipitation", "Predisposition", "Production", "Public Health", "Research", "Residual state", "Resistance", "Respiration", "Respirators", "Risk", "Saline", "Small Business Innovation Research Grant", "Stream", "System", "Technology", "Testing", "Time", "Tuberculosis", "Viral", "capsule", "commercialization", "current pandemic", "design", "disease transmission", "global health", "health care settings", "improved", "innovation", "microorganism", "miniaturize", "next generation", "novel", "novel strategies", "operation", "pandemic disease", "particle", "particle counter", "pathogen", "pathogenic bacteria", "pathogenic virus", "pressure", "prototype", "respiratory", "respiratory pathogen", "response", "seal", "supply chain", "surgical mask", "transmission process", "viral pandemic", "voltage", "wasting", "worker safety" ], "approved": true } }, { "type": "Grant", "id": "12167", "attributes": { "award_id": "1K23HL169743-01", "title": "Sustainable Implementation of Prone Positioning for the Acute Respiratory Distress Syndrome", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 24579, "first_name": "Susan", "last_name": "Shero", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-05", "end_date": "2028-07-31", "award_amount": 178690, "principal_investigator": { "id": 24580, "first_name": "Chad", "last_name": "Hochberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "This career development award will support Chad Hochberg, MD MHS, to become an independent investigator in critical care implementation science. In this award, Dr. Hochberg will build on his prior NHBLI-funded F32 studies investigating the changes in critical care practice that occurred early in the coronavirus disease 19 (COVID-19) pandemic. With this award, he seeks further training in 1) Informatics to monitor and support implementation, 2) Survey methodology, and 3) Developing, adapting, and evaluating implementation strategies for intensive care unit (ICU) implementation trials. To achieve these goals, he has outlined a 5-year career development plan that involves targeted didactics, hands-on research experience, and intensive mentoring. This research and training will be facilitated by the highly supportive training environment at the Johns Hopkins University, and guided by an experienced mentorship team with relevant expertise. Acute respiratory distress syndrome (ARDS) is a common and deadly form of respiratory failure in patients receiving mechanical ventilation. Prone positioning, a key evidence-based practice (EBP) for ARDS, involves positioning patients to lie on their stomachs, facilitating less injurious mechanical ventilation. Despite strong evidence that prone positioning reduces risk of death, it was historically underused. However, during the early COVID-19 pandemic, the use of prone positioning in patients with COVID-19 ARDS drastically increased compared to historic practice. Yet, preliminary data show falling proning rates, and other implementation experience suggests that without active intervention, appropriate use of this life-saving measure will decline. The strategies needed to support the sustainability of prone positioning in ICU practice are unknown. In this K23, Dr. Hochberg will use an established implementation framework, the dynamic sustainability framework, to structure an investigation into the strategies needed to support sustainability of prone positioning in ICU practice. In Aim 1, he will use granular patient-level data combined with staff surveys of ICU implementation climate from the five-hospital Johns Hopkins Health System, and evaluate the associations between the continued use of proning over time with specific patient characteristics and ICU implementation climate domains. In Aim 2, he will further explore the influence of ICU climate and culture on proning processes using a sequential explanatory mixed methods design. Finally, in Aim 3, he will conduct a pilot implementation trial to support further penetration and sustainability of prone positioning in routine ICU practice, and will assess the feasibility, acceptability, and appropriateness of this intervention using validated implementation surveys of ICU staff. This research and training will establish a strong foundation for a career focused on implementation science in critical care, and provide the preliminary data and experience for Dr. Hochberg to conduct a future R01-level multisite intervention to improve the implementation of prone positioning and other EBPs for ARDS.", "keywords": [ "Acute Respiratory Distress Syndrome", "Adoption", "Agreement", "Award", "Belief", "COVID-19", "COVID-19 pandemic", "COVID-19 patient", "COVID-19/ARDS", "Chad", "Characteristics", "Climate", "Computerized Medical Record", "Critical Care", "Data", "Data Analyses", "Data Set", "Development Plans", "Disease", "Eligibility Determination", "Environment", "Etiology", "Evidence based practice", "Face", "Feedback", "Foundations", "Funding", "Future", "Gases", "Goals", "Guidelines", "Health system", "Hospitals", "Implementation readiness", "Informatics", "Intensive Care Units", "Interdisciplinary Study", "Intervention", "Interview", "Investigation", "K-Series Research Career Programs", "Leadership", "Learning", "Life", "Lung", "Measures", "Mechanical ventilation", "Mentors", "Mentorship", "Meta-Analysis", "Methods", "Monitor", "Morbidity - disease rate", "Organization administrative structures", "Organizational Culture", "Patient Care", "Patient-Focused Outcomes", "Patients", "Penetration", "Positioning Attribute", "Process", "Prone Position", "Recommendation", "Research", "Research Personnel", "Respiratory Failure", "Retrospective cohort study", "Review Literature", "Risk Reduction", "Severities", "Site", "Stomach", "Structure", "Survey Methodology", "Surveys", "Syndrome", "Testing", "Time", "Training", "Universities", "Work", "career", "career development", "design", "efficacy outcomes", "evidence base", "experience", "falls", "hands on research", "high risk", "hospital care", "implementation evaluation", "implementation framework", "implementation intervention", "implementation science", "implementation strategy", "implementation trial", "improved", "member", "mortality", "mortality risk", "novel", "organizational climate", "organizational readiness", "pandemic disease", "primary outcome", "routine practice", "sustainability framework", "uptake" ], "approved": true } }, { "type": "Grant", "id": "12168", "attributes": { "award_id": "1R01AI175618-01", "title": "Multiplexed detection of cell-free M. Tuberculosis DNA and its drug-resistant variants in blood", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 7856, "first_name": "Karen A.", "last_name": "Lacourciere", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-11", "end_date": "2028-07-31", "award_amount": 753352, "principal_investigator": { "id": 28032, "first_name": "Tony Y.", "last_name": "Hu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28033, "first_name": "Jeffrey", "last_name": "Tornheim", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 811, "ror": "", "name": "TULANE UNIVERSITY OF LOUISIANA", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "Every year 10 million people fall ill with tuberculosis (TB) and 1.5 million people die from TB – making it the leading cause of death from infectious disease – but TB can be difficult to diagnose. Extended M. tuberculosis (Mtb) cultures are still often used for diagnosis. PCR-based assays (e.g. Xpert MTB/RIF) that detect TB DNA can provide more rapid results, but require special equipment and, like Mtb culture, exhibit reduced sensitivity when employed to analyze sputum from individuals with extrapulmonary TB or compromised immune systems. Blood-based TB assays should detect all forms of TB, but current tests analyze the immune response to Mtb antigens and cannot distinguish active and latent TB. Sensitive detection of Mtb-derived cell-free DNA (cfDNA) in the circulation, however, represents a potential new means for enhanced TB diagnosis. Circulating cfDNA is rapidly degraded after its release and disease-associated cfDNA levels in blood can rapidly change in response to pathologic changes and physiologic responses. This short half-life can enable “real-time” cfDNA analyses required for accurate evaluation of the current status of active Mtb infections and rapid granular evaluation of Mtb treatment responses. However, the limit of detection (LoD) of current PCR-based assays are not sufficient to reliably detect Mtb cfDNA in blood. We have established a CRISPR-Cas12a-based detection system that can ultra-sensitively detect trace amount of SARS-CoV-2 RNA in blood to diagnose COVID-19, predict disease severity, and evaluate infection resolution. We have adapted this approach to develop a blood-based multiplexed CRISPR-mediated TB diagnosis (CRISPR-TBD) assay that can detect circulating Mtb cfDNA, including SNPs responsible for drug-resistant TB. Our preliminary data from longitudinal serum samples of patients undergoing TB treatment provide strong proof-of-principle evidence for the clinical utility of this platform. We have adapted this approach to a paper strip-based point of care (POC) CRISPR-TBD detection platform suitable for use in resource-limited regions with high TB burden, without decreasing assay sensitivity. We now propose to: 1) systematically optimize all CRISPR-TBD paper strip assay steps to improve quantitative detection of Mtb-cfDNA in POC settings; 2) evaluate the performance of this POC assay to diagnose pulmonary and extrapulmonary TB and to identify drug-sensitive and -resistant TB cases; 3) quantify Mtb-cfDNA changes in serum during TB treatment as a measure of treatment efficacy or failure and for early detection of nascent drug resistance; and 4) in-field validate the diagnostic performance of this POC assay in an independent TB patient cohort when performed in a clinical laboratory in a high endemic TB region and evaluate in parallel the performance our predictive Mtb-cfDNA model for TB treatment.", "keywords": [ "2019-nCoV", "Address", "Affect", "Aftercare", "Antitubercular Agents", "Archives", "Area", "Bacillus", "Biological Assay", "Biopsy", "Blood", "Blood specimen", "Body Fluids", "COVID-19 detection", "COVID-19 diagnosis", "COVID-19 pandemic", "Cause of Death", "Cells", "Child", "Circulation", "Clinical", "Clinical Data", "Clustered Regularly Interspaced Short Palindromic Repeats", "Communicable Diseases", "DNA", "DNA amplification", "DNA analysis", "Data", "Detection", "Diagnosis", "Diagnostic", "Diagnostic tests", "Disease", "Drug Evaluation", "Drug resistance", "Drug resistance in tuberculosis", "Early Diagnosis", "Equipment", "Evaluation", "Exhibits", "Extreme drug resistant tuberculosis", "Face", "Genetic Recombination", "Goals", "HIV", "Half-Life", "Health Resources", "Healthcare", "Immune response", "Immune system", "India", "Individual", "Infection", "Interferon Type II", "Isoniazid resistance", "Laboratories", "Longitudinal cohort study", "Lung", "Measures", "Mediating", "Methods", "Modeling", "Monitor", "Multidrug-Resistant Tuberculosis", "Mycobacterium tuberculosis", "Mycobacterium tuberculosis antigens", "Paper", "Pathologic", "Patients", "Performance", "Persons", "Pharmaceutical Preparations", "Physiological", "Plasma", "Polymerase", "Population", "Prediction of Response to Therapy", "Predisposition", "Prevalence", "Prognosis", "Prospective cohort", "Public Health", "RNA", "Reaction", "Reader", "Relapse", "Resistance", "Resolution", "Resource-limited setting", "Resources", "Respiratory Disease", "Retrospective cohort", "Rifampicin resistance", "Sampling", "Sensitivity and Specificity", "Serum", "Severities", "Severity of illness", "South Africa", "Special Equipment", "Specificity", "Sputum", "Testing", "Time", "Tissues", "Treatment Efficacy", "Treatment Failure", "Tuberculosis", "Tuberculosis diagnosis", "United States National Institutes of Health", "Urine", "Validation", "Variant", "X Inactivation", "accurate diagnosis", "biobank", "biomedical referral center", "cell free DNA", "clinical research site", "cohort", "detection assay", "detection limit", "detection platform", "diagnostic assay", "disorder control", "drug-sensitive", "falls", "follow-up", "immune function", "improved", "lipoarabinomannan", "mortality", "multiplex detection", "novel", "patient population", "point of care", "point of care testing", "point-of-care diagnosis", "prognostic performance", "q" ], "approved": true } }, { "type": "Grant", "id": "12169", "attributes": { "award_id": "1P30AG083257-01", "title": "Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 27534, "first_name": "Elise", "last_name": "Rice", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-15", "end_date": "2028-06-30", "award_amount": 758806, "principal_investigator": { "id": 28034, "first_name": "William Tzu-lung", "last_name": "Hu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28035, "first_name": "Bei", "last_name": "Wu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1856, "ror": "", "name": "RUTGERS BIOMEDICAL AND HEALTH SCIENCES", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "Asian and Pacific Americans (APAs) have undergone the greatest growth among all racial/ethnic groups in the U.S. between 2000 and 2020. In the New York City/New Jersey (NYC/NJ) area, older (65+) Asian Indian and Chinese American populations have increased by 73% and 74% over the past ten years. While claims-based studies in the U.S. have previously suggested lower prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) in older APAs, this finding may have resulted from underdiagnosis associated with not having culturally and linguistically appropriate tools, clinicians, or systems. Older APAs with AD/ADRD in the U.S. thus face both the problem of under-diagnosis and under-provision of care as a whole, even as great disparities exist within and between APA subgroups. What’s more, the COVID-19 pandemic and the associated anti-Asian discrimination brought greater social isolation to older Chinese and non-Chinese APA adults over the past three years than other groups. These factors together formed the foundation of the Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) with missions of 1) increasing scientists underrepresented in AD/ADRD-related Behavioral, Social, and Economic Research biomedical research through innovative models of mentoring and community interaction; 2) advancing the rigor and impact of AD/ADRD pilot studies in older APAs through Common Data Elements and data-sharing; 3) serving as a national resource for linguistically/culturally tested and validated tools to assess cognition, function, and AD/ADRD care in APA populations. Focusing on the theme of People, Culture, Place, Time, RCASIA will leverage strong institutional support and relationships to solicit pilot applications from Early Stage Investigators (ESIs). We will actively engage and encourage applications from ESIs at NYC/NJ-based Minority Serving Institutions through pre-application RCASIA internships and partnership commitments from large funded studies prospectively recruiting disaggregated older APAs. Scientist mentoring will occur in the Research Education Component (co-led by a returning REC Core Lead and a newly recruited yet established AD/ADRD Education/Psychosocial Core Lead) involving mentoring/method-based Pods and ethnicity-based Teams. REC will be supported by the Leadership & Administrative Core, the Measurement & Analytical Core, and Community Liaison & Recruitment Core in selecting each year’s class of RCASIA Scientists, enhancing multi-generational method and career development in Pods, conducting transdisciplinary engagement with Community & Lived Advisors in Teams, and evaluating the outcomes of Scientists, effectiveness of the Pod/Team model, impact of Common Data Elements and data sharing, and long-term relationships between RCASIA and funded Scientists. Returning and new faculty’s commitment to diversity, equity, inclusion, and access and APA brain health will contribute to RCASIA’s goal of becoming the epicenter for AD/ADRD-related Behavioral, Social, and Economic Research in older APA populations.", "keywords": [ "Acculturation", "Adult", "Age Years", "Aging", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease related dementia", "Alzheimer&apos", "s disease risk", "American", "Area", "Asia", "Asian", "Asian Americans", "Asian Indian", "Atherosclerosis", "Award", "Behavior", "Behavioral", "Biomedical Research", "COVID-19 pandemic", "Career Mobility", "Caring", "Cause of Death", "Chinese", "Chinese American", "Cities", "Cognition", "Cognitive", "Cohort Studies", "Common Data Element", "Communities", "Complement", "Country", "Data", "Data Set", "Dementia", "Development", "Diagnosis", "Discipline", "Discrimination", "Disparate", "Disparity", "East Asian", "Economics", "Education", "Effectiveness", "Elderly", "Ethnic Origin", "Ethnic Population", "Face", "Faculty", "Foundations", "Funding", "Goals", "Growth", "Health", "Health Policy", "Health Promotion", "Immigration", "Institution", "Internships", "Knowledge", "Language", "Lead", "Leadership", "Learning", "Linguistics", "Low Prevalence", "Measurement", "Mediator", "Medicare claim", "Mentors", "Meta-Analysis", "Methodology", "Methods", "Minority", "Minority-Serving Institution", "Mission", "Modeling", "Native Hawaiian or Other Pacific Islander", "New Jersey", "New York", "New York City", "Outcome", "Participant", "Peer Review", "Personal Satisfaction", "Persons", "Phase", "Pilot Projects", "Policy Maker", "Population", "Population Study", "Prevalence", "Prospective Studies", "Publications", "Recording of previous events", "Research", "Research Personnel", "Resources", "Scientist", "Social isolation", "South Asian", "Stress", "Subgroup", "Surveys", "System", "Testing", "Time", "anti-Asian", "apprenticeship", "brain health", "career", "career development", "cohort", "data sharing", "dementia care", "education research", "equity diversity and inclusion", "experience", "health equity", "health inequalities", "improved", "innovation", "insight", "method development", "metropolitan", "multidisciplinary", "next generation", "outreach", "pandemic disease", "prospective", "psychosocial", "racial population", "racism", "recruit", "social", "social culture", "social stigma", "success", "tool" ], "approved": true } }, { "type": "Grant", "id": "12170", "attributes": { "award_id": "1G08LM014107-01A1", "title": "Reading Bees: Adapting and Testing a Mobile App Designed to Empower Families to Read more Interactively with Children in Distinct Geographical and Cultural Contexts", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Library of Medicine (NLM)" ], "program_reference_codes": [], "program_officials": [ { "id": 26724, "first_name": "Meryl", "last_name": "Sufian", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-04", "end_date": "2026-07-31", "award_amount": 150000, "principal_investigator": { "id": 28036, "first_name": "John S.", "last_name": "hutton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "Many children arrive at kindergarten unprepared to learn to read, at-risk of falling more behind, with major inequities linked to race, geography and poverty (rates >50%). These are amplified during disruptions such as COVID, when access to information and resources is perturbed. Low proficiency is strongly linked to adverse school, vocational and health outcomes, with estimated costs >$350 billion/year. As parents are a child’s “first and most important teachers,” home reading routines have a large impact on these outcomes. However, there are wide disparities in these between high- and low-resource families, fueled by household stressors, cultural differences, literacy challenges and other factors. Marginalized families also often face barriers to access of reliable literacy-promoting information, programs and resources, worsening disparities. Given trusted access to families when parenting routines are shaped, health providers are poised to help mitigate these barriers, yet guidance tends to be general, inconsistent and can fade-out at home. The objective of the proposed project is to enhance, “localize” and test a new, free mobile app designed to provide reliable shared reading guidance and resources for parents (Reading Bees; RB) in an efficient, engaging way. The rationale is that no similar approach exists, RB is free and designed to enhance existing programs, and there is evidence that its features will be useful and effective. Content is evidence-based and has been co-developed with input from community stakeholders and families from disadvantaged backgrounds. Core principles are clarity, credibility, flexibility (e.g., parents set their own goals), responsiveness (child age, family concerns, ZIP), engaging content (tips, videos, resources) and positive reinforcement (“LitCoin” awards). The long-term goal of this project is to use RB to help improve reading and literacy outcomes. To achieve this, teams in 3 culturally distinct areas (OH, WV, FL) will collaborate in a 3-year project. Content will first be added to address needs in each community: lists of local reading-related resources curated by area stakeholders and a Spanish language version of RB. Enhanced, “localized” RB will then be tested with parents in each area, first through focus groups to gauge usefulness and guide refinement, and then by providing RB to parents (ages 0-6) during clinic visits and measuring use over the next 2 months. Outcome measures involve feasibility, acceptance and useflness. The central hypothesis is that local stakeholders will be engaged by the opportunity to highlight resources in their area; families will rate RB content as useful and use RB often, especially to earn LitCoin awards; and improved access to information and resources will fuel better reading and literacy outcomes. This work is significant and innovative as it involves a tech-enabled, user-centered approach that is scalable within existing pediatric, library and program infrastructure and empowers parents to read more interactively and access reliable information. The expected outcome is that this work will provide vital enhancements to RB, show feasibility and usefulness and provide a flexible, collaborative model to “localize” and scale use of RB into other areas.", "keywords": [ "6 year old", "Academy", "Access to Information", "Address", "Adherence", "Adult", "Age", "American", "Android", "Appalachian Region", "Area", "Attitude", "Award", "Bees", "Behavior", "Black race", "Books", "Brain", "COVID-19 pandemic", "Caring", "Categories", "Child", "Child Rearing", "Childhood", "Clinic Visits", "Code", "Cognitive", "Collaborations", "Communities", "Complement", "Complex", "Data", "Development", "Disadvantaged", "Disparity", "Emotional", "Environment", "Evaluation", "Face", "Family", "Focus Groups", "Frequencies", "Geography", "Gifts", "Goals", "Growth", "Health", "Health Personnel", "Hispanic", "Home", "Household", "Huntington Disease", "Immigrant", "Improve Access", "Incentives", "Inequity", "Infrastructure", "Journals", "Knowledge", "Language", "Learning", "Libraries", "Link", "Literacy Programs", "Measures", "Minority", "Modeling", "Nursery Schools", "Outcome", "Outcome Measure", "Outcome Study", "Parents", "Pediatrics", "Populations at Risk", "Positive Reinforcements", "Poverty", "Process", "Provider", "Race", "Readiness", "Reading", "Recommendation", "Reporting", "Resources", "Rural", "School Enrollments", "Schools", "Series", "Services", "Shapes", "Stress", "Surveys", "Testing", "Time", "Translating", "Trust", "United States National Library of Medicine", "Visit", "Vocation", "Work", "Writing", "cognitive benefits", "coronavirus disease", "cost", "cost estimate", "design", "disadvantaged background", "early childhood", "empowerment", "evidence base", "experience", "fall risk", "financial incentive", "flexibility", "health literacy", "impression", "improved", "infancy", "innovation", "kindergarten", "literacy", "marginalization", "mobile application", "pilot trial", "programs", "skills", "socioeconomic disadvantage", "stressor", "teacher", "tool", "tutoring", "usability", "verbal" ], "approved": true } }, { "type": "Grant", "id": "12171", "attributes": { "award_id": "3U01HG007269-09S2", "title": "IGNITE Cost Extension - Admin Supplement", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 28037, "first_name": "simona", "last_name": "volpi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-01", "end_date": "2025-06-30", "award_amount": 1351790, "principal_investigator": { "id": 28038, "first_name": "Larisa Humma", "last_name": "Cavallari", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28039, "first_name": "JULIE A.", "last_name": "JOHNSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 158, "ror": "https://ror.org/02y3ad647", "name": "University of Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The current administrative supplement request is for a 24-month extension with funding to complete the ongoing IGNITE Network pragmatic clinical trials, GUARDD-US and ADOPT-PGx. The GUARDD-US and ADOPT-PGx, have been underway since July 2020 and February 2021, respectively. These trials will help determine the impact of implementing genetic testing on hypertension, depression, and pain therapies. GUARDD-US: Chronic kidney disease (CKD) is associated with hypertension. People with African ancestry (AAs) have the highest risk of CKD and kidney failure, the highest prevalence of hypertension, and the lowest rate of blood pressure (BP) control. While this disparity is in part due to social determinants, ancestry has biological underpinnings, and APOL1 high- risk genetic variants, exclusively found in AAs, increase kidney failure risk 10-fold. We propose a genotype- guided trial to determine the effect of early vs. delayed knowledge of a positive APOL1 genotyping result on 3- month systolic blood pressure (SBP). The clinical trial aims to recruit African Americans with hypertension, with or without CKD, randomized to immediate versus delayed return of APOL1 genetic testing. In those who are APOL1 negative, we will also conduct a pilot study to test the impact of pharmacogenetic (PGx) testing on SBP. ADOPT-PGx: Pain and depression are conditions that impact substantial proportions of the US population. The treatment of acute and chronic pain is challenged by the difficulty of finding effective therapies while minimizing the risk of adverse effects or opioid addiction. For depression, there are few clinically relevant predictors of successful treatment, which results in inadequate therapy for many patients. We propose a prospective randomized pragmatic genotype-guided clinical trial that tests the effect of genotype-guided therapy in three scenarios of patients: acute post-surgical pain, chronic pain, and depression. For each scenario participants will be randomized to genotype-guided drug therapy versus usual approaches to drug therapy selection. Changes in patient-reported outcomes representing pain and depression control using standard PROMIS scales define the primary endpoints. Secondary analyses include safety endpoints, changes in overall well-being, and economic impact represented by differences in healthcare utilization. A 24-month extension with funding is needed due to unanticipated network-wide delays in launching each trial and shutdowns due to COVID-19. The funding requested in this administrative supplement reflects the trial needs as well as enrollment of 50 additional participants for the Depression Trial to address recruitment shortfalls by other groups and for the costs associated with leading analyses and publication costs for 15 secondary manuscripts.", "keywords": [ "APOL1 gene", "Acute", "Acute Pain", "Address", "Administrative Supplement", "Adult", "Adverse effects", "African American population", "African ancestry", "Antidepressive Agents", "Biological", "Blood Pressure", "COVID-19", "Chronic Kidney Failure", "Clinical", "Clinical Trials", "Data", "Disparity", "Dose", "Effectiveness", "Enrollment", "Ethnic Origin", "Florida", "Funding", "Future", "Genomic medicine", "Genomics", "Genotype", "Guidelines", "Health", "Healthcare", "High Prevalence", "Hypertension", "Kidney Failure", "Knowledge", "Manuscripts", "Mental Depression", "Opiate Addiction", "Opioid", "Outcome", "Pain", "Pain management", "Participant", "Patient Outcomes Assessments", "Patients", "Personal Satisfaction", "Persons", "Pharmaceutical Preparations", "Pharmacogenetics", "Pharmacogenomics", "Pharmacotherapy", "Pilot Projects", "Population", "Population Heterogeneity", "Postoperative Pain", "Pragmatic clinical trial", "Provider", "Publications", "Race", "Randomized", "Risk", "Safety", "Selection for Treatments", "Site", "Test Result", "Testing", "Time", "Universities", "Vulnerable Populations", "blood pressure control", "chronic pain", "clinically relevant", "comparison control", "cost", "demographics", "depressive symptoms", "economic impact", "effective therapy", "genetic testing", "genetic variant", "health care service utilization", "health difference", "health disparity", "high risk", "hypertension control", "hypertensive", "improved", "opioid therapy", "participant enrollment", "patient population", "pharmacogenetic testing", "primary endpoint", "primary outcome", "prospective", "recruit", "risk minimization", "secondary analysis", "social determinants", "treatment arm", "treatment as usual" ], "approved": true } }, { "type": "Grant", "id": "12172", "attributes": { "award_id": "1DP1DA058988-01", "title": "ÚNETE: Combining Friendship Support Networks and Targeted Messaging from Celebrity Influencers to Reduce Latinx Substance Use Disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 26314, "first_name": "ALEXA RUTH", "last_name": "Romberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-01", "end_date": "2028-06-30", "award_amount": 1074500, "principal_investigator": { "id": 26603, "first_name": "Mariano Juan", "last_name": "Kanamori Nishimura", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 872, "ror": "", "name": "UNIVERSITY OF MIAMI SCHOOL OF MEDICINE", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The NIDA News Release for August 2022 highlights the striking problem that young adults in the US face as the COVID-19 pandemic endures: “Marijuana and hallucinogen use among young adults reached all time-high in 2021…past-month nicotine and marijuana vaping levels rebound after early pandemic drop.” We propose a randomized controlled trial of ÚNETE, an innovative multilevel strategy that combines friendship support networks and targeted messaging from celebrity influencers (actors, singers and sport players) to reduce drug use disparities and the negative effects of social determinants of health in Latinx communities. We will focus on low-income, young adult Latinx (19 to 30 years old), who, as predominantly immigrants or first-generation US citizens, suffer from health disparities as well as discrimination. ÚNETE will be implemented in South Florida, where Latinx are 69% of residents, and are three times as likely as non-Latinx Whites to live below the poverty line. Our overall goal is to evaluate effectiveness of the ÚNETE strategy to reduce drug use (marijuana, hallucinogen, nicotine and marijuana vaping). The strategy has three components: 1. Celebrity Influencer Component of 30 celebrities. We will work with celebrity influencers and low-income, young adult Latinx to develop and culturally tailor messages to facilitate conversations and improve friends’ understanding of the risks of drug use. We will produce and pre-test these messages, featuring celebrity influencers, in multiple formats to allow dissemination through principal media channels (television, radio, streaming video, websites, gaming, interactive). 2. Latinx Friendship Networks (groups of 13 friends). Community Health Workers (CHWs) will map the structure of each friendship network. CHWs and popular individuals from each network will use this information to design a one- three- and nine-month plan to increase drug use prevention conversations based on celebrity messages. 3. CHWs will encourage information sharing of Social Determinants of Health Services provided by our community partners (e.g., food security, ESL, housing and transportation, legal services), and build network cohesion to increase peer support for accessing these services. Participants will be randomly assigned to either ÚNETE (N=24 seeds and 288 recruits through friendship ties) or a standard health promotion (N=312). Assessments will be conducted at baseline, 6, and 12 months. ÚNETE’s multidisciplinary team includes a Latinx PI working with Latinx communities, two of the most important community organizations providing social determinant of health services to low-income Latinx in South Florida (Open Arms and MUJER), experts in celebrity-based campaigns with international and local Latinx celebrities, and a Latinx broadcast media partner that reaches and engages Latinx throughout the US. ÚNETE is innovative and high impact because its use of tailored messages from celebrity influencers amplified through Latinx friendship networks can scale up interventions reaching larger populations, generating broad impacts to public health and increase access to services addressing social determinants of health.", "keywords": [ "Address", "Binding", "Broadcast Media", "COVID-19 pandemic", "Communities", "Community Health Aides", "Discrimination", "Disparity", "Drops", "Drug usage", "Face", "Florida", "Friends", "Friendships", "Generations", "Goals", "Hallucinogens", "Health Promotion", "Health Services", "Health Services Accessibility", "Housing", "Immigrant", "Individual", "International", "Intervention", "Latinx", "Legal", "Low income", "Maps", "Marijuana", "National Institute of Drug Abuse", "Nicotine", "Participant", "Population", "Poverty", "Public Health", "Radio", "Randomized", "Randomized Controlled Trials", "Risk", "Services", "Sports", "Stream", "Structure", "Television", "Testing", "Time", "Transportation", "Work", "arm", "cohesion", "community organizations", "design", "drug abuse prevention", "effectiveness evaluation", "food security", "health disparity", "improved", "innovation", "marijuana vaping", "multidisciplinary", "news", "pandemic disease", "peer support", "recruit", "reduced substance use", "scale up", "social health determinants", "substance use", "support network", "tailored messaging", "web site", "young adult" ], "approved": true } }, { "type": "Grant", "id": "12173", "attributes": { "award_id": "1RF1MH134561-01", "title": "The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 25615, "first_name": "Leonardo", "last_name": "Cubillos", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-15", "end_date": "2026-08-14", "award_amount": 2696906, "principal_investigator": { "id": 28040, "first_name": "Chris", "last_name": "Desmond", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28041, "first_name": "Jeremy Calvin", "last_name": "Kane", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Social determinants of health (SDOH), such as education, employment, housing, and food security, were all impacted by the COVID-19 pandemic and associated lockdowns. These changes to SDOH were particularly impactful in low-and-middle-income countries (LMIC) such as South Africa in which populations have a high risk of exposure to adversities that were exacerbated by COVID-19 lockdowns (e.g., economic instability, violence, family separation and loss). Although several studies conducted during the pandemic linked lockdowns and changes in SDOH to adverse mental health outcomes, these studies were predominantly cross-sectional, which precludes the ability to evaluate: i) the impact of changes in SDOH on mental health over time; ii) whether initial impacts of COVID-19 persist long-term; and iii) the mechanisms through which changes in SDOH impact mental health, which are necessary for identifying potential intervention points. Further, adolescents and young adults (AYA; ages 18-25) have not been a major focus of COVID-19 mental health research, which is a gap because this is an age range during which individuals finish education and transition into new roles, both professional and personal. This period is also when incident mental health disorders often first occur and shapes the probability that they will continue. This study addresses these gaps by leveraging an existing large, population-based cohort of over 1100 AYA and their caregivers in in South Africa, the Asenze cohort. Four waves of data collection through 2022 have captured longitudinal measurements on mental, behavioral, and physical health outcomes as well as SDOH correlates. This provides a rare opportunity to investigate changes in AYA mental health before, during, and after the height of the pandemic in a LMIC that has been substantially impacted by COVID-19 – South Africa has experienced the highest number of COVID-19 cases, deaths, and excess mortality due to the pandemic in Africa. In this mixed methods study, we will investigate the impact of COVID-19-related SDOH changes on mental health among AYA in the Asenze cohort. Specifically, we will model changes in mental health outcomes from pre-COVID-19 and the acute COVID-19 phases (Asenze Wave 3, collected 2020-2021 and Wave 4, collected 2022) to the post-acute COVID phase (Wave 5, 2024-2025) and how these changes may have been impacted by SDOH (e.g., access to education, employment, availability of health care, food security, exposure to violence). We will examine mechanisms (mediators) underlying the relationship between SDOH and mental health and key populations (moderators) to foster resilience. Qualitative data building on prior qualitative and quantitative data, will provide an in-depth, complementary, and contextual understanding on AYA mental health during and COVID-19 and perceptions on the acceptability and appropriateness of interventions that target mechanisms and key populations identified in the quantitative data. The findings will provide near-term information on possible intervention points through which SDOH impacts mental health in the context of COVID- 19, and long-term information to inform intervention approaches in future public health emergencies.", "keywords": [ "Acute", "Address", "Adolescence", "Adolescent and Young Adult", "Adult", "Affect", "Africa", "Age", "Aging", "Anxiety", "COVID-19", "COVID-19 impact", "COVID-19 pandemic", "COVID-19 pandemic effects", "Caregivers", "Cessation of life", "Characteristics", "Child", "Cohort Studies", "Communities", "Country", "Data", "Data Collection", "Economics", "Education", "Elderly", "Employment", "Etiology", "Excess Mortality", "Exposure to", "Family", "Fostering", "Funding", "Future", "Gender", "HIV", "Height", "Housing", "Income", "Individual", "International", "Intervention", "Interview", "Link", "Literature", "Longitudinal Studies", "Longitudinal cohort", "Maps", "Measurement", "Mediation", "Mediator", "Mental Depression", "Mental Health", "Mental disorders", "Methods", "Modeling", "Orphan", "Outcome", "Parents", "Perception", "Phase", "Population", "Positioning Attribute", "Preschool Child", "Probability", "Prospective cohort", "Qualitative Methods", "Reporting", "Research", "Risk Reduction", "Role", "Rural", "SARS-CoV-2 transmission", "Series", "Shapes", "South Africa", "Time", "United States National Institutes of Health", "Violence", "adolescent health", "behavioral health", "cohort", "coronavirus disease", "critical developmental period", "design", "experience", "food security", "global health", "health care availability", "high risk", "innovation", "low and middle-income countries", "pandemic disease", "pandemic impact", "physical conditioning", "population based", "prevent", "primary caregiver", "psychosocial", "public health emergency", "resilience", "response", "social", "social health determinants", "substance use", "timeline", "violence exposure" ], "approved": true } }, { "type": "Grant", "id": "12174", "attributes": { "award_id": "1R21AI160687-01A1", "title": "Identification of lung resident innate lymphocytes that specifically protect neonates from SARS-CoV-2 infections", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 26918, "first_name": "Michelle Marie", "last_name": "Arnold", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-08", "end_date": "2025-07-31", "award_amount": 293125, "principal_investigator": { "id": 28042, "first_name": "Joonsoo", "last_name": "Kang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 790, "ror": "", "name": "UNIV OF MASSACHUSETTS MED SCH WORCESTER", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Immunological regulation of mucosal barrier development and maintenance is a critical process for infant health, as imbalances in immune sentinel activity can lead to lung, skin and gut inflammatory diseases. Central to the mucosal tissue homeostasis are Type 3 cytokine producing lymphocytes (T3L). In mice, fetal-origin γδTCR+ T3L called Tγδ17 cells dominantly regulate skin homeostasis and mediate protective immunity to influenza infections soon after birth. Tγδ17 cells are classified as innate lymphocytes as their effector function is programmed in the thymus before they migrate to populate the lung and skin. There, Tγδ17 cells respond rapidly to environmental cues to fortify the tissue barriers and coordinate pathogen clearance. Tγδ17 cells are representative of the class of innate T3L (iT3L) that include multiple cell types, whose major distinctions are how they recognize environmental cues and at what age of tissues they functionally dominate. SARS-CoV-2 infections are particularly dangerous for the elderly, while children are resistant to severe COVID-19. This exploratory proposal will test the hypothesis that neonatal lung Tγδ17 cells, or other iT3L, confer protection against SARS-CoV-2. Rationale for the hypothesis is built on four foundational observations: 1. SARS-CoV-2 infected children generate T3 responses while the aged only show muted responses, if at all; 2. Murine lung Tγδ17 cells protect against sepsis, a disease with similarity to severe COVID-19; 3. Neonatal Tγδ17 cells protect lung tissues against Influenza in mice; and 4. Attrition of Tγδ17 cells occurs with aging. It follows that the severe COVID-19 in elderly are in part caused by compromised lung iT3L protection with age. This project will establish T3L composition and activation status pre- and post- SARS-CoV-2 infection in neonates and adults, identify lung iT3L subset(s) that dominantly confer resistance to SARS-CoV-2 infections in neonates, and determine how diet and infection history impacts Tγδ17 cell-mediated lung protective responses to respiratory infections. By understanding how the young successfully respond to SARS-CoV-2 new insights into why the aged succumb to COVID-19 can be obtained. 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