Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=other_investigators" }, "data": [ { "type": "Grant", "id": "9242", "attributes": { "award_id": "5R01AI157827-02", "title": "Point-of-Care RT-PCR System to Inform COVID-19 and Respiratory Illness Decisions", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6011, "first_name": "Erik J.", "last_name": "Stemmy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-18", "end_date": "2025-08-31", "award_amount": 788805, "principal_investigator": { "id": 22809, "first_name": "Nicholas M", "last_name": "Adams", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 189, "ror": "https://ror.org/02vm5rt34", "name": "Vanderbilt University", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22810, "first_name": "Frederick R", "last_name": "Haselton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 22811, "first_name": "Jonathan E", "last_name": "Schmitz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 189, "ror": "https://ror.org/02vm5rt34", "name": "Vanderbilt University", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "The ongoing COVID-19/SARS-CoV-2 pandemic highlights the need for simple, rapid, and cost-effective testing for respiratory infections at the point-of-care, including physician’s offices, urgent-care settings, ambulatory procedural centers, and low-resource environments. The need is particularly notable for respiratory infections, such as COVID-19 and influenza, which can present with similar symptoms yet require distinct management strategies. With its high sensitivity and specificity, RT-PCR is the gold standard for the molecular diagnosis and differentiation among respiratory pathogens. Traditional RT-PCR workflow requires significant control over specimen contents and reaction conditions, with current methods requiring nucleic acid extraction prior to amplification and detection. The net result is increased complexity, cost, and/or turnaround time for diagnosis. In this context, we have observed in recent influenza studies that outstanding analytic performance characteristics can be achieved without RNA extraction, by applying our novel workflow and Adaptive PCR technology. Unlike traditional RT-PCR, Adaptive RT-PCR incorporates mirror-image L-DNA enantiomers— identical in sequence to PCR primers and targets—that modify cycling conditions to match the biochemical sample contents, thus eliminating the need to monitor reaction temperature. The direct monitoring of reaction conditions overcomes many of the limitations of traditional PCR, facilitating direct amplification within the original specimen matrix, simplifying instrument design, and enabling single-tube analyses. SARS-CoV-2 and influenza are both enveloped RNA viruses, with specimens collected in the same manner (i.e. nasopharyngeal swab) and using the same viral transport medium. Therefore, we hypothesize that we may eliminate RNA extraction for this virus, like we have done for influenza, by performing Adaptive RT-PCR directly on clinical specimens. We propose to enable a simplified methodology through Adaptive RT-PCR, creating diagnostics for COVID-19 and other respiratory pathogens without RNA extraction. As a collaboration between biomedical engineers and a COVID-19 diagnostic laboratory, we seek to develop a workflow and instrument that are simple-to-use, cost-effective, and suitable for point-of-care settings, tools that can rapidly inform treatment and management strategies. To achieve this goal, Aim 1 will evaluate the performance of RT- PCR directly – that is, without RNA extraction – using both traditional and Adaptive RT-PCR instrumentation. Aim 2 will develop multiplexed amplification reagents to create a sensitive and specific respiratory panel that detects SARS-CoV-2, four other viruses, two bacteria, and one control target. Ultimately, Aim 3 will design and fabricate a self-contained Adaptive RT-PCR instrument suitable for point-of-care settings, while validating this system using characterized human specimens in a CLIA-accredited lab environment. Completion of this project will result in a novel point-of-care tool for both the established and emerging respiratory infections that threaten public health, facilitating rapid treatment, follow-up, infection prevention, and epidemiologic containment.", "keywords": [ "2019-nCoV", "Academic Medical Centers", "Bacteria", "Bacterial Infections", "Biochemical", "Biomedical Engineering", "CLIA certified", "COVID-19", "COVID-19 assay", "COVID-19 detection", "COVID-19 diagnostic", "COVID-19 pandemic", "COVID-19 testing", "Characteristics", "Clinic", "Clinical", "Collaborations", "Containment", "DNA", "Data", "Device Designs", "Devices", "Diagnosis", "Diagnostic", "Engineering", "Environment", "Epidemiology", "Goals", "Gold", "Health", "Human", "Image", "Infection", "Infection prevention", "Infectious Diseases Research", "Influenza", "Laboratories", "Light", "Methodology", "Methods", "Molecular", "Molecular Diagnosis", "Monitor", "Nucleic Acids", "Optics", "Patients", "Performance", "Physicians", "Physicians&apos", "Offices", "Population", "Preparation", "Public Health", "RNA", "RNA Viruses", "RNase P", "Reaction", "Reagent", "Reporting", "Resources", "Respiratory Tract Infections", "Reverse Transcriptase Polymerase Chain Reaction", "Sampling", "Sensitivity and Specificity", "Specificity", "Specimen", "Supportive care", "Symptoms", "System", "Technology", "Temperature", "Tennessee", "Testing", "Time", "Training", "Tube", "Viral", "Virus", "Work", "amplification detection", "base", "clinically relevant", "cost", "cost effective", "design", "diagnostic assay", "enantiomer", "experience", "follow-up", "instrument", "instrumentation", "molecular diagnostics", "multiplex assay", "nasopharyngeal swab", "novel", "pathogen", "point of care", "point-of-care diagnostics", "preclinical evaluation", "primary care setting", "research clinical testing", "respiratory", "respiratory pathogen", "tool", "urgent care" ], "approved": true } }, { "type": "Grant", "id": "7030", "attributes": { "award_id": "3U01MD010644-05S1", "title": "Addressing Emotional Wellness among COVID-19 informal first-responders: REJOICE-P", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8046, "first_name": "Nathaniel", "last_name": "Stinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-05-01", "end_date": "2021-08-31", "award_amount": 169556, "principal_investigator": { "id": 22814, "first_name": "Tiffany Francine", "last_name": "Haynes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22815, "first_name": "Karen Hye-cheon Kim", "last_name": "Yeary", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic is currently devastating many communities across America1–3. The increases in infection, unemployment, and death are straining resources in disadvantaged communities, such as rural African American communities4. In rural African American communities, pastors are serving as informal first- responders, responding to the communities social and emotional needs associated with the COVID-19 pandemic5. For example, many are experiencing increased psychological distress such as anxiety and depressive symptoms related to the COVID-19 pandemic. Given the decreased access to formal mental health services46, pastors are responsible for addressing the emotional concerns7 of congregants in addition to addressing other psychosocial needs such as the need for financial support and food.5 Pastors, a population already at risk for psychological distress and burn-out,8,9 are experiencing an increase in psychological stress related to these added demands5; thereby, increasing the likelihood that rural African American pastors will experience emotional unwellness (i.e. emotional distress or strain that can lead to the development of mental illness). The parent grant seeks to test the effectiveness of a culturally adapted an evidence-based intervention to address emotional wellness in rural African American adults of faith. The multi-level intervention is based on behavioral activation (BA), an evidence-based psychotherapy for the treatment of depression that focuses on identifying and scheduling personally meaningful activities to reduce depressive symptoms while simultaneously addressing obstacles (i.e. avoidance) to participating in identified activities. Small groups led by lay leaders undergo an 8-session faith-based behavioral activation protocol that provides individuals with education about: identifying depressive symptoms, identifying pleasurable activities, scheduling pleasurable activities, and identifying and addressing avoidant behaviors that act as barriers to completing pleasurable activities. Given the specific need of pastors serving as informal first responders, this supplement seeks to refine the existing REJOICE intervention to provide pastors with skills to improve personal emotional wellness related to serving on the first-lines of the COVID-19 pandemic and build the capacity of pastors to adequately respond to the emotional needs of rural African Americans. Specifically, this supplement aims to:1) Refine REJOICE for use with rural African American pastors serving as informal first-responders during the COVID-19 pandemic and 2) Assess the feasibility and acceptability of a faith-based behavioral activation intervention (REJOICE) for use with African American pastors serving as informal first-responders during the COVID-19 pandemic.", "keywords": [ "Address", "Adult", "Advocate", "African American", "American", "Anxiety", "Behavior", "Behavioral", "COVID-19", "COVID-19 pandemic", "Cessation of life", "Church", "Communities", "Community Healthcare", "Contracts", "Coupled", "Data", "Disadvantaged", "Economics", "Education", "Emergency Situation", "Emotional", "Evidence based intervention", "Financial Support", "Food", "Funding", "Health", "Health Professional", "Hotlines", "Individual", "Infection", "Intervention", "Lead", "Mental Depression", "Mental Health", "Mental disorders", "Pastoral Care", "Pattern", "Play", "Police", "Population", "Protocols documentation", "Psychological Stress", "Psychotherapy", "Public Health", "Reporting", "Resources", "Risk", "Role", "Schedule", "Sleep disturbances", "Social Work", "Stretching", "Testing", "Thinness", "Training", "Unemployment", "anxiety symptoms", "base", "burnout", "coronavirus disease", "depressive symptoms", "effectiveness testing", "emotional distress", "emotional experience", "evidence base", "experience", "first responder", "health care service", "improved", "infection risk", "mental development", "pandemic disease", "parent grant", "physical conditioning", "pleasure", "psychologic", "psychological distress", "psychosocial", "response", "rural African American", "skills", "social", "volunteer" ], "approved": true } }, { "type": "Grant", "id": "7032", "attributes": { "award_id": "3U54CA199090-06S1", "title": "Repurposing of cancer therapeutics for treatment of patients with COVID-19 disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22660, "first_name": "LEELA RANI RANI", "last_name": "Avula", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-08-01", "end_date": "2021-07-31", "award_amount": 183000, "principal_investigator": { "id": 22817, "first_name": "James R.", "last_name": "Heath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 954, "ror": "https://ror.org/02tpgw303", "name": "Institute for Systems Biology", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22818, "first_name": "ANTONI", "last_name": "RIBAS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 954, "ror": "https://ror.org/02tpgw303", "name": "Institute for Systems Biology", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The pandemic COVID-19 has, as of April 13, 2020, infected nearly 2M individuals worldwide, with over 560,000 U.S. cases and over 22,000 U.S. deaths. There are no FDA approved vaccines or treatments for COVID-19. This supplemental proposal describes the accelerated development of such a drug, with potential near-term uses of these early therapeutic candidates for probing the structural-function relationships between the SARS-CoV-2 spike protein and the human ACE2 receptor protein. This work builds directly from Project 2 of the NCI-supported U54 NSBCC program. The specific aims of that project center around the technology of Protein Catalyzed Capture agents (PCCs),1 with a specific focus on developing technologies for the high-through production of PCCs, as well as an emphasis on drug-targeting the KRASG12D oncoprotein. A unique aspect of PCCs is that they are, by design, developed to bind to a specific epitope on a specific protein,2 thus providing an avenue for targeting an epitope containing a genetic mutation (relevant to oncoproteins),3 or providing an avenue for targeting epitopes that are broadly conserved, which bears relevance to targeting strategies aimed at the SARS- CoV-2 coronavirus. That NSBCC-funded project has proceeded well (with progress towards KRASG12D-specific inhibitors recently attracting additional investments). Further, we have also recently shown, using other funding, that the platform can be harnessed to selectively target antibiotic resistance pathogens using a variant of the PCC technology termed antibody-recruiting(AR) PCCs.4 Here we seek to combine the high-throughput aspect of PCC development that has been supported by the NCI,5 with the pathogen-targeting approach, to develop a series of precisely targeted inhibitors against SARS-CoV-2. This work has already been moving forward for the past few weeks, and is nearing the point where animal model work will soon be required.", "keywords": [ "2019-nCoV", "Administrative Supplement", "Affinity", "Animal Model", "Antibiotic Resistance", "Antibodies", "Binding", "Bioinformatics", "Biological Assay", "COVID-19", "COVID-19 pandemic", "Cancer Biology", "Cancer Center", "Cessation of life", "Consensus", "Coronavirus", "Coupled", "DNA Sequence Alteration", "Development", "Disease", "Drug Targeting", "Engineering", "Ensure", "Epitopes", "FDA approved", "Funding", "Grant", "Human", "Immunoglobulin Variable Region", "In Situ", "In Vitro", "Individual", "Investments", "Libraries", "Ligand Binding", "Ligands", "Malignant Neoplasms", "Modeling", "Mus", "National Cancer Institute", "Oncoproteins", "Patients", "Peptides", "Pharmaceutical Preparations", "Pneumonia", "Production", "Proteins", "Reporting", "Research Design", "Series", "Severe Acute Respiratory Syndrome", "Structure-Activity Relationship", "Technology", "Therapeutic", "Ursidae Family", "Vaccines", "Variant", "Virus", "Work", "comparative", "design", "in vivo", "inhibitor/antagonist", "molecular dynamics", "mouse model", "nanosystems", "neutralizing antibody", "pathogen", "pharmacokinetics and pharmacodynamics", "pre-clinical", "programs", "receptor", "recruit", "response", "screening", "small molecule", "therapeutic candidate", "unnatural amino acids" ], "approved": true } }, { "type": "Grant", "id": "7034", "attributes": { "award_id": "3U54MD007601-34S3", "title": "Ola HAWAII", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 7638, "first_name": "Richard", "last_name": "Berzon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-09-01", "end_date": "2022-06-30", "award_amount": 211615, "principal_investigator": { "id": 22820, "first_name": "Jerris Robert", "last_name": "Hedges", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 866, "ror": "https://ror.org/01wspgy28", "name": "University of Hawaii at Manoa", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22821, "first_name": "Noreen", "last_name": "Mokuau", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 866, "ror": "https://ror.org/01wspgy28", "name": "University of Hawaii at Manoa", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true }, "abstract": "Achieving “ola” (health in Hawaiian) for the communities suffering disproportionately from genetic, environmental and socioeconomic disparities in health is the rationale for the proposed RCMI Specialized Center at the University of Hawaii at Manoa. The objective of the Center, named Ola HAWAII, is to grow and support a community of health disparities investigators (the “workforce”) to harness the power of diverse thought (the “thinkforce”) to determine the causes of and interventions for health disparities. The Center's objective will be achieved by the following specific aims. Specific Aim 1: Foster and facilitate the conduct of high-impact team-science research addressing health disparities. Plan: Involve all stakeholders in decision-making process of selecting meritorious project proposals and provide funding and infrastructure support for scientifically rigorous R01/R21-type basic biomedical, behavioral and clinical research projects on health disparities. Promote collaborations and partnerships with other RCMI grantee institutions through the RCMI Translational Research Network (RTRN). Specific Aim 2: Strengthen and diversify the basic biomedical, behavioral and clinical research workforce and thinkforce focusing on health disparities. Plan. Identify the most motivated basic biomedical, behavioral and clinical faculty, particularly those from underrepresented backgrounds, for careers in health disparities research. Identify senior faculty to serve on mentoring teams for new and early-stage investigators. Implement a Team-Science Mentoring Bootcamp for personalized education and skills training. Implement a Team-Science Pilot Projects Program to provide funding, on a competitive basis, to new and early-stage investigators to generate data for grant applications. Specific Aim 3: Enhance, consolidate and sustain core facilities and resources for health disparities research. Plan. Implement objective criteria and metrics to evaluate core needs and usage, core-dependent research productivity, and revenue generation. Consolidate core resources to reduce redundancies. Provide modest funding through a “CoreBucks” Program to maximize utilization of core resources and services across RTRN. Institutional investments will ensure the sustainability of the proposed RCMI Specialized Center to provide the infrastructure and resources for a new era of research excellence on the science of health disparities.", "keywords": [ "Address", "Adopted", "Aging", "Applications Grants", "Behavioral", "Behavioral Research", "Biological Sciences", "Biomedical Research", "Burn injury", "Cancer Center", "Clinical", "Clinical Research", "Collaborations", "Communities", "Community Health", "Core Facility", "Data", "Decision Making", "Dental Hygiene", "Ensure", "Faculty", "Filipino", "Fostering", "Funding", "Generations", "Genetic", "Goals", "Hawaii", "Hawaiian population", "Health", "Health Professional", "Health Resources", "Health Sciences", "Indigenous", "Inequality", "Infrastructure", "Institution", "Intervention", "Investments", "Knowledge", "Marketing", "Mentors", "Minority-Serving Institution", "Myron", "Names", "Native Hawaiian", "Natural Sciences", "Nursing Faculty", "Pacific Island Americans", "Pilot Projects", "Population", "Process", "Productivity", "Program Development", "Public Health", "Publications", "Records", "Research", "Research Activity", "Research Ethics", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Resources", "School Nursing", "Schools", "Science", "Services", "Social Welfare", "Social Work", "Specialized Center", "System", "Training and Education", "Translational Research", "Trust", "Underrepresented Populations", "United States National Institutes of Health", "Universities", "Vulnerable Populations", "base", "career", "career development", "college", "community partnership", "design", "education research", "experience", "healing", "health care availability", "health disparity", "healthcare community", "improved", "medical schools", "minority health", "next generation", "operation", "outreach", "programs", "senior faculty", "skills training", "socioeconomic disparity", "socioeconomics", "user-friendly", "web portal" ], "approved": true } }, { "type": "Grant", "id": "9245", "attributes": { "award_id": "3U54MD007601-34S2", "title": "Community Driven Approach to Mitigate COVID 19 Disparities in Hawaii's Vulnerable Populations", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 7638, "first_name": "Richard", "last_name": "Berzon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-22", "end_date": "2023-06-30", "award_amount": 3400883, "principal_investigator": { "id": 22820, "first_name": "Jerris Robert", "last_name": "Hedges", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 866, "ror": "https://ror.org/01wspgy28", "name": "University of Hawaii at Manoa", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22821, "first_name": "Noreen", "last_name": "Mokuau", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 866, "ror": "https://ror.org/01wspgy28", "name": "University of Hawaii at Manoa", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true }, "abstract": "The long-term goal of this proposal is to eliminate COVID-19 disparities among Hawaii’s racial/ethnically diverse yet vulnerable populations including Native Hawaiian and other Pacific Islanders (NHPI) living in rural and underserved communities by integrating innovative SARS-CoV-2 testing capacity with novel community-specific messaging and education. Compounded by long-standing health disparities and socioeconomic challenges, NHPIs suffer from increased infection and mortality rates attributed to COVID-19. To date, NHPIs rank among the highest disproportionately burdened by SARS-CoV-2 in the U.S. With the nation’s highest Rt, a basic reproductive metric indicating the degree of viral spread, Hawaii’s disaggregated NHPI data reveal further disparities. Preliminary testing data collected by our partner, the Waianae Coast Comprehensive Health Center (WCCHC), Hawaii’s largest federally funded community health center, indicates a significant deficiency in testing uptake, especially among Pacific Islanders. Further, we observed under-representative coverage of testing among youth (ages 5-19 years old) in NHPI communities, despite their higher than average infection rate. Other factors, including slow testing turnaround time and untested asymptomatic cases, complicate efforts to contain further community spread. Given the looming public health concerns around re-opening businesses and schools, these gaps highlight the critical need for innovative approaches of effecting behavioral change coupled with novel testing strategies to enhance access to all community members, including school-aged children/youth. Fortunately, our partnerships in Hawaii’s culturally diverse populations offer a unique opportunity to augment the current COVID-19 response with community knowledge and resilience. We propose the hypothesis that community-contextualized messaging disseminated by novel healthcare-school partnerships coupled with a robust community and patient-centered testing strategy will increase reach, access, uptake, and impact for COVID-19 testing in vulnerable populations. To test this hypothesis, our multidisciplinary team aims to (1) evaluate SARS-CoV-2 testing data, identify gaps and barriers in testing, and augment community testing capacity to increase uptake and (2) optimize and implement community-informed COVID-19 messaging and education with a novel community healthcare-school network partnership in the NHPI population across Hawaii. Building on our parent “Ola HAWAII” grant, this project leverages our existing Community Engagement, Biostatistics, and Administrative Cores with NHPI partnerships to augment the RADx-UP Coordinating and Data Collection Center for common evaluation metrics on COVID-19 testing-related outcomes and implementation. This will lay the foundation for an engaged community network primed for disseminating anticipated vaccines in Hawaii’s highest risk populations. Given the urgency to both improve public health safety and re-opening schools, results from this project may offer insights into an integrated model or toolkit from which health clinics and schools in underserved & vulnerable communities across the country might actively participate in abating this pandemic.", "keywords": [ "19 year old", "2019-nCoV", "Abate", "Address", "Age", "Behavior", "Behavioral", "Biometry", "Businesses", "COVID-19", "Caring", "Child", "Chronic", "Clinic", "Collaborations", "Communities", "Community Healthcare", "Community Networks", "Conflict (Psychology)", "Country", "Coupled", "Data", "Data Collection", "Discrimination", "Education", "Educational Curriculum", "Evaluation", "Exposure to", "FDA approved", "Family", "Filipino", "Foundations", "Fright", "Funding", "Goals", "Grant", "Growth", "Hawaii", "Health", "Health Personnel", "Health Professional", "Healthcare", "Hotlines", "Household", "Housing", "Individual", "Infection", "K-12 Education", "Knowledge", "Language", "Mission", "Modeling", "Molecular Diagnostic Testing", "Native Hawaiian", "Neighborhood Health Center", "Occupations", "Outcome", "Pacific Island Americans", "Parents", "Perception", "Physicians", "Population", "Population Heterogeneity", "Poverty", "Protocols documentation", "Public Health", "Public Health Education", "Race", "Recording of previous events", "Research", "Research Personnel", "Rural", "Rural Community", "Safety", "School-Age Population", "Schools", "Science", "Services", "Site", "Students", "Technology", "Testing", "Time", "Vaccines", "Viral", "Vulnerable Populations", "Youth", "base", "community center", "design", "ethnic disparity", "ethnic diversity", "health care availability", "health disparity", "high risk population", "improved", "infection rate", "innovation", "insight", "member", "mortality", "multidisciplinary", "novel", "outreach", "outreach program", "pandemic disease", "patient oriented", "racial and ethnic", "remote communities", "reproductive", "resilience", "response", "rural underserved", "socioeconomics", "tool", "uptake" ], "approved": true } }, { "type": "Grant", "id": "7038", "attributes": { "award_id": "3R33ES024719-05S1", "title": "Low-Cost Versatile Sampler for Personal PM Exposure by Microenvironment", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 10732, "first_name": "Yuxia", "last_name": "Cui", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-25", "end_date": "2022-07-31", "award_amount": 431880, "principal_investigator": { "id": 4432, "first_name": "Charles S", "last_name": "Henry", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 323, "ror": "https://ror.org/03k1gpj17", "name": "Colorado State University", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22822, "first_name": "John", "last_name": "Volckens", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 323, "ror": "https://ror.org/03k1gpj17", "name": "Colorado State University", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "Stemming the spread of the SARS-CoV-2 pandemic is a leading public health priority. The relative importance of various transmission modes (e.g., surface contact, large droplet impact, small droplet aerosol), however, remains uncertain. This uncertainty hinders the prioritization of controls and undermines the validity of current guidelines (e.g., the 6-ft social distancing rule). Therefore, research is needed to elucidate whether large droplet or fine-mode aerosol inhalation are viable modes of disease transmittance. A major limitation of the extant research is that aerosol samples have not been collected within the breathing zone of individuals (whether they are infected or not); this limitation stems from the cost and physical burden posed by existing personal (wearable) air sampling technologies. We propose to adapt technologies developed under our existing grant (R33ES024719 Low-Cost, Versatile Sampler for Personal PM Exposure) for the detection of aerosolized SARS-CoV-2 RNA within the human breathing zone. We propose to collect the following types of real-world air samples from active healthcare facilities in Colorado: 1) patient breathing zone (symptomatic and asymptomatic), 2) room area (surface and air), and 3) healthcare worker breathing zone. We also propose to quantify viral RNA levels using a novel low-cost microfluidic assay. We hypothesize that enhanced bioshedding of SARS-CoV-2 aerosol will occur in the breathing zone of infected individuals (relative to matched samples collected at a 6-ft distance). Further, we will test this hypothesis for both droplet (up to 100 µm) and lung- penetrating (< 10 µm) aerosol by segregating collected samples by particle size. The information gained from this research will inform stakeholders about the relative importance of personal protective equipment, personal distancing, and local ventilation controls.", "keywords": [ "2019-nCoV", "Aerosols", "Air", "Area", "Biological Assay", "Breathing", "Colorado", "Data", "Detection", "Disease", "Equipment", "Funding", "Grant", "Guidelines", "Health", "Health Personnel", "Health care facility", "Human", "Individual", "Inhalation", "Lung", "Microfluidics", "Paper", "Particle Size", "Patients", "RNA", "Research", "Sampling", "Social Distance", "Surface", "Technology", "Testing", "Time", "Uncertainty", "aerosolized", "air sampling", "base", "cost", "novel", "pandemic disease", "public health priorities", "stem", "transmission process", "ventilation", "viral RNA" ], "approved": true } }, { "type": "Grant", "id": "7039", "attributes": { "award_id": "3P30AG064200-02S1", "title": "Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8106, "first_name": "LISA", "last_name": "ONKEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-15", "end_date": "2024-05-31", "award_amount": 281998, "principal_investigator": { "id": 22823, "first_name": "Carolyn Kay", "last_name": "Clevenger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22824, "first_name": "Ken W", "last_name": "Hepburn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 22825, "first_name": "MOLLY M", "last_name": "PERKINS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract. This application seeks support for an administrative supplement to the Emory Roybal Center for Dementia Caregiving Mastery (P30AG06400). We seek to develop and test a broadly accessible and readily scalable online fully asynchronous course for family caregivers of community-dwelling persons living with dementing disorders like Alzheimer's disease to prepare them to master the new demands of their caregiving role in the extraordinary circumstance of the coronavirus (COVID-19) pandemic. Under normal circumstances, caregivers need to learn how to guide their person through safe, calm, and pleasant days. In a time of COVID- 19, caregivers have to learn how to take all of the complicated precautions to keep themselves and their persons from being exposed to the virus. They need skills for keeping their persons occupied and calm in a “shelter in place” world where day programs or other regular outings to large group settings (e.g., places of worship) are unavailable. And they need skills for navigating the healthcare system to manage their person's health in ways that minimize the need to use emergency or acute services. We seek to produce an online course that can be completed in 4-6 weeks that will develop and enhance caregivers' mastery not only to provide effective day-to-day care guidance, but to ensure their care recipients' health and safety, and to function as healthcare system navigators for their care recipients. The course will engage caregivers in self- paced learning in a format tailored to and calibrated for a lay learning audience. It will be structured as a small group “class,” of 20-30 participants who will interact virtually but never meet as a group, and whose activities and exercises will be monitored by a course faculty member. In our Aim 1 activities, we propose to develop, in collaboration with an educational design consultant team, the online course designed to teach these skills. The project will seek input from caregivers, clinicians, and other experts – and used the Roybal Center's Design Studio capacity – to develop the structure, content, and “feel” of the course and produce a testable prototype. In our Aim 2 activities, we will recruit 100 family caregivers to take part in a quantitative and qualitative wait-list control randomized trial of the prototype course. The trial will assess usability and acceptability and it will be sufficiently powered to examine the preliminary efficacy of the course to develop caregiving mastery and benefit caregivers' well-being. Formative evaluation data, course faculty observation, and course use data will be used to produce a revised version of the course. MPIs Hepburn and Clevenger bring psychoeducation and continuing education program development experience and extensive clinical and caregiver expertise to the project – and an established working relationship with the educational consulting team. The Aim 2 test will provide the basis for an application for a larger randomized trial through an R01 mechanism. The results of the Aim 2 test will also support making the course more widely available through reliable channels that can provide appropriate course supervision, such as the NIA-supported Alzheimer's Disease Centers.", "keywords": [ "Acute", "Administrative Supplement", "Affect", "African American", "Alzheimer&apos", "s Disease", "American", "Belief", "COVID-19", "COVID-19 pandemic", "Caregiver support", "Caregiver well-being", "Caregivers", "Center for Translational Science Activities", "Clinic", "Clinical", "Collaborations", "Communities", "Competence", "Consult", "Continuing Education", "Coronavirus", "Course Content", "Data", "Day Care", "Dementia", "Development", "Disease", "Economic Conditions", "Emergency Situation", "Enrollment", "Ensure", "Exercise", "Exposure to", "Faculty", "Family Caregiver", "Family member", "Fostering", "Future", "Health", "Healthcare", "Healthcare Systems", "Home environment", "Infection", "Instruction", "Interview", "Knowledge", "Learning", "Link", "Measures", "Medical center", "Monitor", "Participant", "Personal Satisfaction", "Persons", "Play", "Process", "Program Development", "Qualitative Research", "Randomized", "Research", "Research Personnel", "Research Project Grants", "Resources", "Role", "Safety", "Services", "Shelter facility", "Social Distance", "Source", "Specialist", "Structure", "Supervision", "Surface", "Taxes", "Testing", "Text", "Time", "Training", "Training and Education", "Vaccines", "Virus", "Waiting Lists", "Work", "base", "care recipients", "caregiver education", "caregiving", "clinical practice", "community based care", "control trial", "coronavirus disease", "cultural values", "dementia caregiving", "design", "expectation", "experience", "faculty research", "formative assessment", "learning materials", "member", "memory care", "online course", "pandemic disease", "patient oriented", "programs", "prototype", "psychoeducation", "randomized trial", "recruit", "response", "skills", "social cognitive theory", "usability", "virtual" ], "approved": true } }, { "type": "Grant", "id": "12069", "attributes": { "award_id": "1R01AG082833-01", "title": "Caregiver as Navigator-Developing Skills Online (CAN-DO): Developing Dementia Family Caregiver Mastery for Navigating Complex Health, Social Service, Legal, Financial, and Family Systems", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21737, "first_name": "Elizabeth Anne", "last_name": "Necka", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-05-31", "award_amount": 772977, "principal_investigator": { "id": 22823, "first_name": "Carolyn Kay", "last_name": "Clevenger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22824, "first_name": "Ken W", "last_name": "Hepburn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The costs and management of Alzheimer’s disease and related disorders are borne by families, the backbone of the care system for persons living with dementia (PLWD). More than 11 million informal caregivers currently guide the daily lives, fortunes, and care system interactions of PLWD. Promoting effective coping behaviors by strengthening caregivers’ capacities for navigating interactions with systems and structures that provide needed care for PLWD may reduce the high levels of caregiver stress. Ensuring that these systems and structures are effectively accessed and deployed may benefit PLWD. The purpose of this study is to test the Caregiver as Navigator: Develop Skills Online (CAN-DO) program on caregiver mastery and emotional well- being as well as caregiver-reported quality of life and behavioral symptoms of their person. CAN-DO focuses on healthcare navigation to include interactions with health, legal, social service, financial and family care systems and care management activities, recognizing that social determinants affect these interactions. This proposal builds on a wait-list control pilot study, Caregiving during Crisis, which assessed the acceptability, feasibility, and preliminary efficacy of a self-paced, online, asynchronous educational program developed to promote caregivers’ mastery of skills for managing care and navigating care systems during the COVID-19 pandemic. Pilot results confirm the pilot study’s primary and secondary hypotheses. We found a significant group x time difference (p=.041) with a moderate effect size (d-0.524) between the intervention (N=37) and usual care wait-list control (N=38) group at the 2-month point on the key measure of caregiver mastery and comparable significant results for improvements in caregivers’ depressive symptoms and caregiver burden. Participant feedback also guides this iteration of content expansion and course interactivity. The CAN-DO study will employ a three-arm wait-list RCT design in which data will be gathered at baseline and then 2, 4, 6, and 8 months later using standard instruments. We will enroll and intentionally diverse sample of 270 caregivers to be clustered in cohorts of 15 and then randomly assigned in a 2:2:1 ratio to three study groups: CAN-DO; a “Healthy Living” attention control condition of comparable size and interactivity; and usual care. We will conduct qualitative interviews to guide further enhancements.", "keywords": [ "Affect", "Alzheimer&apos", "s disease related dementia", "Anxiety", "Area", "Behavioral Symptoms", "COVID-19 pandemic", "Caregiver Burden", "Caregivers", "Caring", "Complex", "Coping Behavior", "Data", "Decision Making", "Dementia", "Dementia caregivers", "Development", "E-learning", "Education", "Educational Models", "Enrollment", "Ensure", "Exclusion", "Exercise", "Family", "Family Caregiver", "Family member", "Feedback", "Fortune", "Friends", "Geography", "Health", "Healthcare", "Healthcare Systems", "Height", "Home", "Hour", "Institution", "Institutionalization", "Intervention", "Interview", "Knowledge", "Legal", "Life", "Managed Care", "Measures", "Mediation", "Medicare/Medicaid", "Mental Depression", "Methods", "Morbidity - disease rate", "Participant", "Persons", "Pilot Projects", "Play", "Program Development", "Psychological reinforcement", "Quality of life", "Race", "Randomized", "Reporting", "Role", "Safety", "Sampling", "Self Efficacy", "Social Work", "Stress", "Structure", "System", "Testing", "Time", "Vertebral column", "Waiting Lists", "Well in self", "arm", "attentional control", "care recipients", "care systems", "caregiver interventions", "caregiver stress", "caregiving", "cohort", "community living", "community setting", "coronavirus disease", "cost", "dementia care", "depressive symptoms", "design", "group intervention", "hands-on learning", "improved", "informal caregiver", "instructor", "instrument", "learning strategy", "pandemic disease", "prevent", "programs", "prototype", "psychoeducation", "psychoeducational", "psychological symptom", "skills", "skills training", "social determinants", "socioeconomics", "standard measure", "treatment as usual", "volunteer" ], "approved": true } }, { "type": "Grant", "id": "14918", "attributes": { "award_id": "5R01AG082833-02", "title": "Caregiver as Navigator-Developing Skills Online (CAN-DO): Developing Dementia Family Caregiver Mastery for Navigating Complex Health, Social Service, Legal, Financial, and Family Systems", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 24603, "first_name": "Melissa", "last_name": "Riddle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-05-31", "award_amount": 763157, "principal_investigator": { "id": 22823, "first_name": "Carolyn Kay", "last_name": "Clevenger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22824, "first_name": "Ken W", "last_name": "Hepburn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The costs and management of Alzheimer’s disease and related disorders are borne by families, the backbone of the care system for persons living with dementia (PLWD). More than 11 million informal caregivers currently guide the daily lives, fortunes, and care system interactions of PLWD. Promoting effective coping behaviors by strengthening caregivers’ capacities for navigating interactions with systems and structures that provide needed care for PLWD may reduce the high levels of caregiver stress. Ensuring that these systems and structures are effectively accessed and deployed may benefit PLWD. The purpose of this study is to test the Caregiver as Navigator: Develop Skills Online (CAN-DO) program on caregiver mastery and emotional well- being as well as caregiver-reported quality of life and behavioral symptoms of their person. CAN-DO focuses on healthcare navigation to include interactions with health, legal, social service, financial and family care systems and care management activities, recognizing that social determinants affect these interactions. This proposal builds on a wait-list control pilot study, Caregiving during Crisis, which assessed the acceptability, feasibility, and preliminary efficacy of a self-paced, online, asynchronous educational program developed to promote caregivers’ mastery of skills for managing care and navigating care systems during the COVID-19 pandemic. Pilot results confirm the pilot study’s primary and secondary hypotheses. We found a significant group x time difference (p=.041) with a moderate effect size (d-0.524) between the intervention (N=37) and usual care wait-list control (N=38) group at the 2-month point on the key measure of caregiver mastery and comparable significant results for improvements in caregivers’ depressive symptoms and caregiver burden. Participant feedback also guides this iteration of content expansion and course interactivity. The CAN-DO study will employ a three-arm wait-list RCT design in which data will be gathered at baseline and then 2, 4, 6, and 8 months later using standard instruments. We will enroll and intentionally diverse sample of 270 caregivers to be clustered in cohorts of 15 and then randomly assigned in a 2:2:1 ratio to three study groups: CAN-DO; a “Healthy Living” attention control condition of comparable size and interactivity; and usual care. We will conduct qualitative interviews to guide further enhancements.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "7039", "attributes": { "award_id": "3P30AG064200-02S1", "title": "Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8106, "first_name": "LISA", "last_name": "ONKEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-15", "end_date": "2024-05-31", "award_amount": 281998, "principal_investigator": { "id": 22823, "first_name": "Carolyn Kay", "last_name": "Clevenger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22824, "first_name": "Ken W", "last_name": "Hepburn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 22825, "first_name": "MOLLY M", "last_name": "PERKINS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract. This application seeks support for an administrative supplement to the Emory Roybal Center for Dementia Caregiving Mastery (P30AG06400). We seek to develop and test a broadly accessible and readily scalable online fully asynchronous course for family caregivers of community-dwelling persons living with dementing disorders like Alzheimer's disease to prepare them to master the new demands of their caregiving role in the extraordinary circumstance of the coronavirus (COVID-19) pandemic. Under normal circumstances, caregivers need to learn how to guide their person through safe, calm, and pleasant days. In a time of COVID- 19, caregivers have to learn how to take all of the complicated precautions to keep themselves and their persons from being exposed to the virus. They need skills for keeping their persons occupied and calm in a “shelter in place” world where day programs or other regular outings to large group settings (e.g., places of worship) are unavailable. And they need skills for navigating the healthcare system to manage their person's health in ways that minimize the need to use emergency or acute services. We seek to produce an online course that can be completed in 4-6 weeks that will develop and enhance caregivers' mastery not only to provide effective day-to-day care guidance, but to ensure their care recipients' health and safety, and to function as healthcare system navigators for their care recipients. The course will engage caregivers in self- paced learning in a format tailored to and calibrated for a lay learning audience. It will be structured as a small group “class,” of 20-30 participants who will interact virtually but never meet as a group, and whose activities and exercises will be monitored by a course faculty member. In our Aim 1 activities, we propose to develop, in collaboration with an educational design consultant team, the online course designed to teach these skills. The project will seek input from caregivers, clinicians, and other experts – and used the Roybal Center's Design Studio capacity – to develop the structure, content, and “feel” of the course and produce a testable prototype. In our Aim 2 activities, we will recruit 100 family caregivers to take part in a quantitative and qualitative wait-list control randomized trial of the prototype course. The trial will assess usability and acceptability and it will be sufficiently powered to examine the preliminary efficacy of the course to develop caregiving mastery and benefit caregivers' well-being. Formative evaluation data, course faculty observation, and course use data will be used to produce a revised version of the course. MPIs Hepburn and Clevenger bring psychoeducation and continuing education program development experience and extensive clinical and caregiver expertise to the project – and an established working relationship with the educational consulting team. The Aim 2 test will provide the basis for an application for a larger randomized trial through an R01 mechanism. The results of the Aim 2 test will also support making the course more widely available through reliable channels that can provide appropriate course supervision, such as the NIA-supported Alzheimer's Disease Centers.", "keywords": [ "Acute", "Administrative Supplement", "Affect", "African American", "Alzheimer&apos", "s Disease", "American", "Belief", "COVID-19", "COVID-19 pandemic", "Caregiver support", "Caregiver well-being", "Caregivers", "Center for Translational Science Activities", "Clinic", "Clinical", "Collaborations", "Communities", "Competence", "Consult", "Continuing Education", "Coronavirus", "Course Content", "Data", "Day Care", "Dementia", "Development", "Disease", "Economic Conditions", "Emergency Situation", "Enrollment", "Ensure", "Exercise", "Exposure to", "Faculty", "Family Caregiver", "Family member", "Fostering", "Future", "Health", "Healthcare", "Healthcare Systems", "Home environment", "Infection", "Instruction", "Interview", "Knowledge", "Learning", "Link", "Measures", "Medical center", "Monitor", "Participant", "Personal Satisfaction", "Persons", "Play", "Process", "Program Development", "Qualitative Research", "Randomized", "Research", "Research Personnel", "Research Project Grants", "Resources", "Role", "Safety", "Services", "Shelter facility", "Social Distance", "Source", "Specialist", "Structure", "Supervision", "Surface", "Taxes", "Testing", "Text", "Time", "Training", "Training and Education", "Vaccines", "Virus", "Waiting Lists", "Work", "base", "care recipients", "caregiver education", "caregiving", "clinical practice", "community based care", "control trial", "coronavirus disease", "cultural values", "dementia caregiving", "design", "expectation", "experience", "faculty research", "formative assessment", "learning materials", "member", "memory care", "online course", "pandemic disease", "patient oriented", "programs", "prototype", "psychoeducation", "randomized trial", "recruit", "response", "skills", "social cognitive theory", "usability", "virtual" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1424, "count": 14236 } } }