Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=funder
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=funder", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=funder", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=funder", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=funder" }, "data": [ { "type": "Grant", "id": "11911", "attributes": { "award_id": "5R33AG078392-02", "title": "FACTORS IN AGING: Best Practices in Archiving and Sharing Interoperable Longitudinal Data Resources on Aging", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 7756, "first_name": "John", "last_name": "Phillips", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2027-06-30", "award_amount": 744047, "principal_investigator": { "id": 24632, "first_name": "JAMES W", "last_name": "MCNALLY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 26868, "first_name": "John Edwin", "last_name": "Marcotte", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "The National Archive of Computerized Data on Aging (NACDA) mission is to create a dynamic and flexible data infrastructure to stimulate health research and advance knowledge related to the gerontological lifecourse. Through the development and delivery of research resources and data services, NACDA alerts researchers to secondary data analysis opportunities, provides tools to locate and access relevant materials, and enhances the availability of gerontological data. NACDA plays a vital role in replicating previous results and discovering new findings. This R33 application enhances NACDA’s ability to support the development of new interdisciplinary collaborations, taking these relationships in significantly new directions. Transforming NACDA’s approach to longitudinal data distribution, we introduce a model based upon data interoperability, a logical extension of NACDA’s work in innovative longitudinal data enhancements. This application introduces NACDA’s adoption of the interoperability model to support aging research for multidisciplinary team science by introducing a standardized infrastructure that integrates existing and emerging findings in a way that accelerates the development of interventions to improve aging-related outcomes. The present application will create the tools and resources to address this need. This application’s specific goals will develop a data-sharing infrastructure to advance data interoperability in emerging scientific areas, facilitating team science and multidisciplinary research. By organizing independent but related data collections into a uniform structure, this application’s outcomes will accelerate aging research beyond what is achievable using existing collections that treat independent data collections as unique objects. 1) Identify- NACDA will continue identifying the universe of aging, formally cataloging these data, providing structured metadata, and physically preserving data collections as appropriate. Using “Common Data Elements” (CDE) approaches, this process will formalize variable-level information and concepts structures. We will create cross-domain XML/DDI templates to unify longitudinal studies across waves for longitudinal aging data identified as high priority by NIA. 2) Integrate- The project will relate the independent longitudinal studies to each other across health thematics, including Alzheimer’s disease and related dementias (ADRD), cognitions, risks associated with COVID 19 complications, existing comorbidities, and broader health conditions. 3) Operationalize – Make the data resources and analysis tools available to the research community and provide ongoing support and training for the interoperability portal. A DDI-based Cross-Domain Interoperability (CDI) framework will maintain the integrated data collections, support services, bibliographic tracking, and social media outreach. The project will provide training and educational services through conference presentations, workshops, and online webinars. This application introduces a sustainable research infrastructure supporting team science.", "keywords": [ "Acceleration", "Address", "Adoption", "Aging", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease related dementia", "Archives", "Area", "Basic Science", "Behavioral Research", "Bibliography", "COVID-19 complications", "COVID-19 risk", "Cataloging", "Clinical Research", "Cognition", "Collection", "Common Data Element", "Communities", "Data", "Data Analyses", "Data Collection", "Democracy", "Development", "Disease", "Documentation", "Educational process of instructing", "Educational workshop", "Extensible Markup Language", "Foundations", "Gerontology", "Goals", "Growth", "Health", "Health Promotion", "Health behavior", "Individual", "Infrastructure", "Interdisciplinary Study", "Knowledge", "Life Cycle Stages", "Longitudinal Studies", "Metadata", "Mission", "Modeling", "Outcome", "Phase", "Play", "Process", "Public Health", "Quality of life", "Research", "Research Infrastructure", "Research Personnel", "Resources", "Role", "Science", "Secondary to", "Services", "Standardization", "Structure", "Techniques", "Training", "Training and Education", "United States National Institutes of Health", "Work", "comorbidity", "computerized", "data infrastructure", "data integration", "data interoperability", "data management", "data portal", "data preservation", "data resource", "data sharing", "digital", "effective intervention", "flexibility", "improved", "innovation", "interdisciplinary collaboration", "interoperability", "operation", "outreach", "repository", "social media", "symposium", "therapy development", "tool", "usability", "web site", "webinar" ], "approved": true } }, { "type": "Grant", "id": "11912", "attributes": { "award_id": "5R01AG078840-02", "title": "Home Health, ADRD, Telehealth, and Patient Outcomes", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 7229, "first_name": "Elena", "last_name": "Fazio", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2026-06-30", "award_amount": 763440, "principal_investigator": { "id": 26339, "first_name": "DANA B", "last_name": "MUKAMEL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Close to 40% of home health patients have been identified as persons with Alzheimer’s Disease or Related Dementias (ADRD). As the prevalence of ADRD in the population in general is expected to double by 2050, so will the percent of patients with ADRD treated by home health agencies. During the Covid-19 pandemic many home health agencies have begun using telehealth technologies, including virtual visits and biomonitoring, to augment and partially substitute in-person, traditional care. This is an acceleration of a trend that began over a decade earlier. A survey has found that by July of 2020, 49% of agencies used some form of telehealth. These two emerging trends, the expected increase in patients with ADRD on the one hand and the increased penetration and utilization of TH by HHAs on the other, raise questions about whether the two are compatible. Can home health care provided via telehealth to patients with ADRD be as good as the care provided to these patients in person? Would it be comparable in terms of patients’ health outcomes and patients’ experience? These questions have not been addressed to-date. Furthermore, there is no information about the type of agencies that adopted telehealth, and in particular among those agencies that care for a majority of ADRD patients. There is also no information about the differences in types of telehealth technologies (e.g. communication telehealth versus biomonitoring) that were adopted. This study will address these questions by: 1.) performing a national survey of home health agencies caring for a majority of patients with ADRD about their telehealth capabilities and use, and the timing of telehealth adoption; 2.) linking survey data to agency characteristics, patients’ health outcomes and patients’ experience data; 3.) analyzing the data statistically to identify agency characteristics associated with different stages of telehealth adoption, the association between telehealth and better patients’ health outcomes and experiences, and the relative ranking of specific telehealth technologies in terms of their association with better patients’ health outcomes and better patients experiences. The information gained in this study will inform home health patients and families, advocates, the industry and CMS, as the issue of payment for telehealth services for home health is moving forward towards consideration by Congress and will influence federal and state policies in the coming years.", "keywords": [ "Acceleration", "Address", "Adopted", "Adoption", "Advocate", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease patient", "Biological Monitoring", "Blood", "Bluetooth", "COVID-19", "COVID-19 pandemic", "Caregivers", "Caring", "Case Mixes", "Characteristics", "Chronic Obstructive Pulmonary Disease", "Communication", "Congresses", "Data", "Data Reporting", "Data Sources", "Dementia", "Family", "Future", "Health", "Health Services", "Health Technology", "Heart Diseases", "Home", "Home Care Services", "Home Health Agency", "Home Health Care Agencies", "Industry", "Link", "Marketing", "Measures", "Medicare", "Medicare claim", "Methodology", "Modality", "Monitor", "Natural experiment", "Occupational Therapy", "Outcome", "Ownership", "Oxygen", "Patient Monitoring", "Patient-Focused Outcomes", "Patients", "Pattern", "Penetration", "Persons", "Physical therapy", "Policies", "Policy Maker", "Population", "Prevalence", "Provider", "Reporting", "Risk Adjustment", "Stroke", "Surveys", "Technology", "Testing", "Visit", "Voice", "cohort", "coronavirus disease", "cost", "evidence base", "experience", "handheld mobile device", "hospice environment", "improved", "insight", "member", "patient home care", "payment", "remote patient monitoring", "telehealth", "traditional care", "transmission process", "trend", "video visit", "virtual visit", "wound treatment" ], "approved": true } }, { "type": "Grant", "id": "11913", "attributes": { "award_id": "5UM2HD111076-02", "title": "Baylor College of Medicine Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-09-22", "end_date": "2029-06-30", "award_amount": 312155, "principal_investigator": { "id": 26869, "first_name": "MARY E", "last_name": "PAUL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 849, "ror": "", "name": "WESTAT, INC.", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Baylor College of Medicine Harris County, which includes the City of Houston, is among the 48 counties in the United States (U.S.) in which more than 50 percent of new HIV diagnoses occur. There is an urgent need for innovative and collaborative new approaches to HIV treatment and prevention in adolescents and young adults (AYA) in Houston. The long-term goal of this research is to move the U.S. and Houston area closer to ending the HIV epidemic by addressing the issues involved in successful prevention and treatment of HIV in AYA. These goals align with Adolescent Trials Network (ATN) research objectives and Houston Consortium partnerships will allow research to be conducted in AYA in all five priority areas of the ATN: improving HIV testing, preventing new infections, engaging youth in care, improving treatment and treatment effectiveness, and reducing adverse HIV health outcomes due to COVID-19. We plan to accomplish the following specific aims as a site for HIV care, research, and prevention in AYA. Aim 1 – Conduct the Trials of the ATN as identified by the ATN Executive Committee (EC) and Scientific Leadership Committee (SLC): Baylor College of Medicine (BCM) ATN site has a longstanding research unit with staff with years of experience working with AYA, both in a clinical trials settings and in the community, who are living with HIV (LWH) or are at risk for HIV. Aim 2 – Participate in the Development of Trials: BCM's ATN Project Lead and staff have years of experience in development and conducting of clinical trials in AYA and so will work in collaboration with the ATN Operations and Collaborations Center (OCC) to develop and conduct the trials performed in the ATN. In addition, the BCM Youth Community Advisory Board, (YCAB), which has had members who have been active in the ATN Youth Advisory Council (YAC) and National CAB, Youth Experts and Advocates for Health (ATN-YEAH), will evaluate and provide input on developing studies and provide and enhance ideas for future studies. Aim 3 – Provide Innovation Regarding Successful Recruitment and Enrollment of Participants: As an ATN Site Consortium, we have the structure, experience, and outreach to approach this aim at multiple levels with outreach in hard-to- reach AYA including racial and gender minority and homeless youth. Aim 4 – Provide Sites (Texas Children's Hospital and Harris Health Northwest and Thomas Street Health Center) as well as outreach within the Houston ATN Consortium, local laboratory capacity, and pharmacy support in order to conduct the ATN trials in collaboration with the OCC. Aim 5 – Continued evaluation and adjustment of Houston collaborative consortium leadership model for meaningful and continued community engagement as reflected in ATN research study participation of AYA at risk for or LWH. We anticipate the expected outcomes of improvements in each ATN priority area along the continuums of HIV infection and prevention. This project is high impact because it will provide the necessary consortium in impacted communities of AYA in a high-priority region of the U.S. to collaborate with the OCC to make sustainable progress in reaching the ATN goals.", "keywords": [ "AIDS prevention", "Acquired Immunodeficiency Syndrome", "Address", "Adherence", "Adolescent Medicine Trials Network", "Adolescent and Young Adult", "Advisory Committees", "Advocate", "Affect", "African American population", "Area", "Black race", "COVID-19", "COVID-19 pandemic", "Caring", "Cities", "Clinical Trials", "Collaborations", "Communities", "Conduct Clinical Trials", "County", "Development", "Discipline of Nursing", "Drug Kinetics", "Epidemic", "Evaluation", "Failure", "Feedback", "Future", "Goals", "HIV", "HIV Infections", "HIV diagnosis", "HIV/AIDS", "Health", "Healthcare", "Heterosexuals", "Hispanic", "Homeless Youth", "Human Resources", "Human immunodeficiency virus test", "Individual", "Infection", "Intervention", "Laboratories", "Latino", "Latinx", "Lead", "Leadership", "Low income", "Medicaid", "Medical", "Medicine", "Minority Groups", "Modality", "Modeling", "Newly Diagnosed", "Online Systems", "Outcome", "Pediatric Hospitals", "Pharmacy facility", "Prevention", "Reporting", "Research", "Risk", "Services", "Site", "Structure", "Technology", "Texas", "Treatment Effectiveness", "Uninsured", "United States", "Work", "Youth", "age group", "case-based", "college", "community engagement", "design", "ethnic minority population", "experience", "gender minority youth", "health inequalities", "high risk", "human old age (65+)", "improved", "improved outcome", "innovation", "male", "marginalized community", "meetings", "member", "motivational enhancement therapy", "novel strategies", "operation", "outreach", "participant enrollment", "pre-exposure prophylaxis", "prevent", "prevention service", "programs", "racial minority", "recruit", "research study", "sexual minority group", "testing services", "transmission process", "treatment services", "uptake" ], "approved": true } }, { "type": "Grant", "id": "11914", "attributes": { "award_id": "5R01AG079282-02", "title": "Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment using novel imaging, molecular markers, and machine learning", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21737, "first_name": "Elizabeth Anne", "last_name": "Necka", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-15", "end_date": "2027-05-31", "award_amount": 672562, "principal_investigator": { "id": 26697, "first_name": "Hugo Javier", "last_name": "Aparicio", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26698, "first_name": "LAURA", "last_name": "BALCER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26699, "first_name": "Joel Armando", "last_name": "Salinas", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Social isolation, loneliness, and social environment continue to emerge as important factors in Alzheimer’s disease and related dementias (ADRD), more so with the COVID-19 pandemic and observed trends in the prevalence of social isolation, loneliness, and ADRD. Although there is increasing recognition these factors can impact the aging brain, represent early expression of ADRD neuropathological changes, and influence health behaviors and resource access, less is known about the biological mechanisms involved. Our overarching hypothesis is that social isolation, loneliness, and social environment are distinct factors that alter brain biology and influence trajectories of healthy neurocognitive aging and ADRD vulnerability. Because understanding causal pathways and the cumulative role of these critical psychosocial factors through decades-long human experimental trials is infeasible, here we propose a unique and innovative approach to comprehensively assess these psychosocial determinants and temporally relate them to dynamic profiles of ADRD vulnerability, leveraging one of the largest biologically well-characterized community-based cohorts in the US, the Framingham Study (FS). Since 1948, FS has enrolled 3 generations of participants (ages 20-50) and 2 multi- ethnic cohorts, examined them regularly for cognitive decline and dementia, and collected an exquisite array of in-depth and cutting-edge “multi-omic”, imaging, and other data over their lifespan and before clinical ADRD onset. The FS has a 70-year legacy of unique contributions to public health, and will continue make breakthroughs in ADRD through its Brain Aging Program (3U19AG068753-02S1). We seek to leverage these resources through the following specific aims: AIM 1 is to examine and explain associations of social isolation, loneliness, and social network structure with ADRD vulnerability over a lifetime. Our prior work in FS suggests a molecular pathway related to neural plasticity/repair and cognitive resilience might be involved in these mechanisms. We will collect a new wave of data on these factors—partially harmonized with the NIH Toolbox and integrate this data with relevant psychosocial information at multiple previous exams. AIM 2 is to identify and validate these biological pathways using causal inference analyses and machine-learning methods on the extensive multi-omics data available. AIM 3 is to characterize social environment’s cumulative role in psychosocial mechanisms of ADRD risk across the adult lifespan by developing a latent social environment index with a validated geocode-based method and conducting sophisticated analyses. We will validate our findings with other multi-ethnic cohort datasets and share all data through dbGaP and bioLINCC. We expect to meaningfully evaluate whether and how these psychosocial factors influence the biology of healthy neurocognitive aging and ADRD vulnerability and identify new pathways that may serve as targets for intervention in the preclinical stage of ADRD. This will advance our understanding of the long-term effects of psychosocial determinants, ADRD prevention, and how to address the root causes of disparities in ADRD.", "keywords": [ "Acceleration", "Address", "Adult", "Age", "Aging", "Algorithms", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease related dementia", "Amyloid beta-Protein", "Anatomy", "Automated Indexing", "Biological", "Biological Markers", "Biological Process", "Biology", "Blinded", "Blood", "Brain", "Brain imaging", "COVID-19 pandemic", "Censuses", "Clinical", "Clinical Trials", "Cognitive", "Cohort Studies", "Communities", "Complement", "Computer Analysis", "Computer Vision Systems", "Computing Methodologies", "Data", "Data Set", "Dementia", "Dimensions", "Disparity", "Economic Conditions", "Enrollment", "Ethnic Origin", "Funding", "Future", "Generations", "Genetic", "Genetic Risk", "Health", "Health Resources", "Health behavior", "Human", "Image", "Impaired cognition", "Incidence", "Individual", "Inflammation", "Inflammatory", "Information Networks", "Intervention", "Intervention Studies", "Intervention Trial", "Link", "Loneliness", "Long-Term Effects", "Longevity", "Machine Learning", "Magnetic Resonance Imaging", "Measures", "Methods", "Molecular", "Molecular Profiling", "Multiomic Data", "Nerve Degeneration", "Neurocognitive", "Neuronal Plasticity", "Neuropsychology", "Participant", "Pathway interactions", "Pattern", "Perfusion", "Population Study", "Positron-Emission Tomography", "Prevalence", "Prevention", "Process", "Proteomics", "Psychosocial Assessment and Care", "Psychosocial Factor", "Public Health", "Publishing", "Research", "Research Priority", "Resources", "Risk", "Role", "Social Environment", "Social Network", "Social isolation", "Socioeconomic Factors", "Stress", "Structure", "Translating", "Treatment/Psychosocial Effects", "United States National Institutes of Health", "Validation", "Vascular Diseases", "Vision", "Work", "aging brain", "amyloid imaging", "brain health", "cognitive function", "cohort", "cytotoxic", "data integration", "data sharing", "database of Genotypes and Phenotypes", "dementia risk", "ethnic diversity", "examination questions", "follow-up", "health determinants", "health equity", "imaging biomarker", "improved", "indexing", "innovation", "interest", "machine learning method", "method development", "molecular marker", "multi-ethnic", "multiple omics", "neurobiological mechanism", "neuropathology", "novel", "open data", "population health", "pre-clinical", "programs", "psychosocial", "public health relevance", "racial diversity", "repaired", "resi" ], "approved": true } }, { "type": "Grant", "id": "11915", "attributes": { "award_id": "5R01MD018548-02", "title": "Big Data Digital Outreach and Epidemiology Methods for HIV Care among Communities of Color", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8046, "first_name": "Nathaniel", "last_name": "Stinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-24", "end_date": "2027-06-30", "award_amount": 778341, "principal_investigator": { "id": 24442, "first_name": "Sean", "last_name": "Young", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "One of the most significant problems in the field of HIV deals with addressing the low rates of HIV care among individuals living with HIV/AIDS, especially among Black/African American and Latinx communities. This application seeks to study a novel way to address that problem by adopting and applying a cutting-edge “big data outreach” approach being used to increase consumer engagement by top technologies companies. This approach has recently been replacing other digital outreach methods largely for privacy reasons-- to conform to stringent European Union privacy laws-- as it involves de-identified data. The digital outreach method being proposed is already being applied in health (but not yet HIV) settings. During the COVID-19 pandemic, our team and others (including the CDC) studied and found success applying these methods for targeted digital recruitment and outreach to those at high-risk for COVID-19. As a result of the COVID-19 pandemic and its effect on use of digital/remote tools, these approaches will soon be applied to HIV to assist in targeting and engaging hard-to reach individuals in HIV research and care. Importantly, the proposed methods allow access to large-scale passively-collected, opt-in, community and mobility (GPS pings) data, which have been shown to add rich and granular data to improve health surveillance and interventions. This application seeks to use these novel digital outreach methods to identify and enroll individuals living with HIV/AIDS from communities of color who are at high-risk for being out of care, and analyze their mobility and community data to identify the key geographic contexts that impact HIV care engagement. We are conducting this effort for, and in partnership with, 2 Ending the HIV Epidemic (EHE) jurisdictions (Washington D.C. and Orange County health departments) and key participant stakeholders to gain their insights on needs, implementation (including ethical concerns), and potential future scale-up of this approach to improve surveillance and intervention efforts. Specifically, we seek to 1) Identify individuals of color living with HIV/AIDS within EHE regions who are at high-risk for being out of care, 2) Using GPS mobility, community (e.g., local crime), and HIV care data, identify the key geographic contexts that impact HIV care engagement, and 3) In partnership with the Washington D.C. and Orange County health departments, explore a case study of the ongoing barriers and facilitators of this approach at the individual, interpersonal, and structural levels. This 1-year cohort study will be focused on identifying people living within an EHE region who have been hard-to-reach for HIV care in order to converge with EHE outcome measures. To our knowledge, this is the first study to apply these novel “big data outreach” methods to HIV, will enroll the largest cohort to date with GPS mobility, community, and other HIV care contextual data, and the first HIV study to passively collect mobility data, which helps to increase data quality and reduce dropout rates compared to previous studies.", "keywords": [ "Address", "Adherence", "Adopted", "Advertisements", "Advertising", "Affect", "African American", "Area", "Big Data", "Black Populations", "Black race", "COVID-19 pandemic", "COVID-19 risk", "Caring", "Case Study", "Clinic", "Cohort Studies", "Color", "Communication", "Communities", "County", "Crime", "Data", "Data Sources", "Devices", "District of Columbia", "Dropout", "Enrollment", "Epidemic", "Epidemiologic Methods", "Epidemiology", "Ethics", "European Union", "Facebook", "Future", "Geography", "HIV", "HIV/AIDS", "Health", "Health Insurance Portability and Accountability Act", "Individual", "Intervention", "Interview", "Knowledge", "Latinx", "Latinx population", "Laws", "Learning", "Machine Learning", "Maps", "Marketing", "Mediator", "Mental Health", "Methods", "Modeling", "Movement", "Neighborhoods", "Oranges", "Outcome Measure", "Participant", "Pattern", "Persons", "Policy Maker", "Prevention", "Privacy", "Process", "Public Health", "Research", "Research Personnel", "Risk", "Sampling", "Services", "Structure", "Surveys", "Target Populations", "Technology", "Time", "United States", "Visualization", "aged", "barrier to care", "care outcomes", "cohort", "data de-identification", "data quality", "data reduction", "design", "digital", "digital communication", "experience", "follow-up", "handheld mobile device", "high risk", "implementation science", "improved", "innovation", "insight", "mobility aid", "novel", "outreach", "participant enrollment", "people of color", "public-private partnership", "recruit", "scale up", "socioeconomics", "stay-at-home order", "success", "tool" ], "approved": true } }, { "type": "Grant", "id": "11916", "attributes": { "award_id": "5R01DA054513-02", "title": "Reduction of opioid requirement associated with Auriculo-nerve stimulation following open surgery", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 23140, "first_name": "Will", "last_name": "Aklin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-01", "end_date": "2026-06-30", "award_amount": 519625, "principal_investigator": { "id": 25623, "first_name": "Jacques E.", "last_name": "Chelly", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25624, "first_name": "Senthilkumar", "last_name": "Sadhasivam", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "PROJECT SUMMARY: Perioperative prescription of opioids is an important contributor to the current opioid epidemic, affecting ~4% of >50 million Americans undergoing surgery each year. The dose and duration of treatment of opioid in surgical patients is an established risk factor of opioid use disorder and overdose deaths. Although legislation and guidelines have been developed to limit the quantity of opioids prescribed following surgery in the US, in 2020, the number of opioid overdose deaths increased by 39% with worsening mental health and opioid use disorder in the context of COVID-19. Developing alternative and effective surgical analgesia and techniques to avoid or minimize the perioperative opioid use and opioid use disorder are critical in the fight of the current opioid epidemic. Auriculotherapy, a form of acupuncture, is an effective opioid-sparing alternative to treat pain. Use of traditional auriculotherapy is limited because the long and specific training requirement. Recently, a novel battery-powered and disposable auriculo-nerve field stimulator, NSS-2 Bridge Device® (NBD®), has been developed to overcome the limitations of the traditional auriculotherapy. NBD® is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear. The device has been cleared by the FDA to treat opioid withdrawal symptoms which includes abdominal pain and anxiety. The NBD® requires minimal training and allow to stimulate the auricular nerves for 5 days making NBD® a potential groundbreaking non-pharmacological approach to limit opioid use and prescription. Rodent studies are supportive of the NBD modulating pain pathways and decreasing inflammatory abdominal pain. Our human surgical pain pilot data is supportive that NBD® was effective in reducing postoperative opioid requirement in adults undergoing open surgery, especially in vulnerable older patients (>65 years). Our central hypothesis is that compared to a placebo, the NBD® will be an effective opioid-sparing tool in patients undergoing open surgery, and that the effectiveness of the NBD would be greater in vulnerable geriatric patients (age >65 years). Since, anxiety, depression, and catastrophizing increase post-operative pain and opioid requirement by up to 50% and since auriculotherapy reduces psychological symptoms, we also hypothesized that using NBD® will also reduce anxiety, depression and catastrophizing and that represents a mechanism by which NBD® reduce perioperative opioid requirements. Our multidisciplinary team is well positioned to test the following specific aims: 1) Quantify the opioid sparing property of NBD® following open surgery in vulnerable geriatric patients in a randomized, blinded, placebo-controlled clinical trial, 2) Evaluate the efficacy of NBD® in reducing postoperative depression, anxiety and catastrophization, and 3) Determine the effects of NBD® on the relationship of the postoperative psychological scores and opioid consumption. This research is expected to improve surgical pain relief, safety of postoperative opioids while minimizing opioid use, dependence, and risk of OUD in millions of Americans who have painful surgeries each year.", "keywords": [ "Abdominal Pain", "Absence of pain sensation", "Acupuncture Therapy", "Adult", "Adverse effects", "Affect", "Age", "American", "Anxiety", "Blinded", "COVID-19", "Cell Nucleus", "Cervical", "Colorectal Surgery", "Conduction Anesthesia", "Controlled Clinical Trials", "Cranial Nerves", "Data", "Dependence", "Development", "Devices", "Dose", "Ear", "Effectiveness", "Elderly", "Face", "Genetic", "Goals", "Guidelines", "Hospitals", "Human", "Inflammatory", "Knowledge", "Limbic System", "Mental Depression", "Mental Health", "Mood Disorders", "Nerve", "Nerve Plexus", "Operative Surgical Procedures", "Opioid", "Outcome", "Overdose", "Pain", "Pathway interactions", "Patients", "Perioperative", "Pilot Projects", "Placebo Control", "Placebos", "Play", "Positioning Attribute", "Postoperative Pain", "Postoperative Period", "Property", "Questionnaires", "Randomized", "Recommendation", "Recording of previous events", "Research", "Risk", "Risk Factors", "Rodent", "Role", "Safety", "Statutes and Laws", "Surgical Oncology", "Techniques", "Testing", "Training", "Trigeminal System", "Withdrawal Symptom", "addiction", "anxiety reduction", "coronavirus disease", "effectiveness evaluation", "efficacy evaluation", "fighting", "glossopharyngeal", "improved", "insight", "multidisciplinary", "neural", "non-opioid analgesic", "novel", "older patient", "opioid epidemic", "opioid mortality", "opioid sparing", "opioid use", "opioid use disorder", "opioid withdrawal", "overdose death", "pain relief", "pandemic disease", "placebo controlled study", "placebo group", "prescription opioid", "prospective", "psychologic", "psychological symptom", "public health relevance", "randomized clinical trials", "surgical pain", "tool", "treatment duration" ], "approved": true } }, { "type": "Grant", "id": "11917", "attributes": { "award_id": "5R01MD016880-02", "title": "Increasing COVID-19 Vaccine Uptake among Latinos through a Targeted Clinical and Community-behavioral Intervention", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6437, "first_name": "Rada K", "last_name": "Dagher", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-21", "end_date": "2025-04-30", "award_amount": 610939, "principal_investigator": { "id": 6288, "first_name": "Noe Cuauhtemoc", "last_name": "Crespo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 775, "ror": "https://ror.org/0264fdx42", "name": "San Diego State University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 6289, "first_name": "Christian B", "last_name": "Ramers", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 775, "ror": "https://ror.org/0264fdx42", "name": "San Diego State University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The United States currently has the highest COVID-19 infection and related mortality rates in the world. In California, Latinos account for the highest percent of COVID-19 cases (58.9%) and deaths (47.3%) and are disproportionately represented in occupations deemed as ‘essential’. Latinos also suffer from higher rates of poverty and chronic disease which places them at greater risk of COVID-19 infection and related complications. In collaboration with Family Health Centers of SD (FHCSD) and working with Community Health Workers (aka, promotores/as), we will implement a multilevel intervention to increase COVID-19 vaccine completion rates and see faster vaccination uptake among Latinos. A total of 10 clinics will be randomized to either a Standard Clinical Practice consisting of standard clinic-based strategies to promote COVID-19 vaccine uptake among patients or a Multilevel Intervention consisting of an individualized/tailored intervention delivered by Health Educators working within the clinics plus a multi-component community intervention delivered by community promotores. This project will test the immediate and short-term effectiveness of the multilevel intervention to increase COVID- 19 vaccine uptake. In addition, we will test the effectiveness of the proposed intervention on long-term behavioral, mental, and physical health outcomes. Lastly, this project will assess implementation outcomes including program acceptability and feasibility by patients and clinic staff and community environment. This study aims to increase the uptake of completing the COVID-19 vaccine in a population that has exceptionally high rates of morbidity and mortality due to COVID-19. We will harness our research team’s extensive experience in developing multi-level interventions working with Health Educators and promotores to promote behavior change among Latinos, and leverage a strong community-academic collaboration that maximizes community impact and sustainability. This research will lead to the development of sustainable and scalable community-academic models designed to respond quickly, efficiently, and effectively to both this existing and future public health threats.", "keywords": [ "Address", "Affect", "Behavior Therapy", "Behavioral", "COVID-19", "COVID-19 monitoring", "COVID-19 mortality", "COVID-19 patient", "COVID-19 risk", "COVID-19 vaccination", "COVID-19 vaccine", "California", "Catchment Area", "Cessation of life", "Chronic Disease", "Clinic", "Clinical", "Cluster randomized trial", "Collaborations", "Communication", "Communities", "Community Health Aides", "County", "Disparity", "Education", "Effectiveness", "Effectiveness of Interventions", "Environment", "FDA Emergency Use Authorization", "Family health status", "Federally Qualified Health Center", "Future", "Government", "Health", "Health Educators", "Health behavior", "Home", "Household", "Infrastructure", "Intervention", "Latin America", "Latino", "Latino Population", "Low income", "Mental Health", "Minority-Serving Institution", "Misinformation", "Modeling", "Morbidity - disease rate", "Neighborhoods", "Occupations", "Outcome", "Patients", "Population", "Positioning Attribute", "Poverty", "Primary Care Physician", "Program Acceptability", "Public Health", "Quality of life", "Randomized", "Research", "Resistance", "Risk", "SARS-CoV-2 infection", "Single-Blind Study", "Subgroup", "Sustainable Development", "System", "Target Populations", "Testing", "Time", "Trust", "Underserved Population", "United States", "United States Dept. of Health and Human Services", "Universities", "Vaccination", "Vaccines", "Work", "acceptability and feasibility", "arm", "behavior change", "behavioral health", "clinical practice", "cohort", "community intervention", "community transmission", "distrust", "economic impact", "effective intervention", "effectiveness evaluation", "effectiveness testing", "ethnic minority population", "experience", "flexibility", "group intervention", "health care service", "high risk population", "implementation evaluation", "implementation fidelity", "implementation outcomes", "implementation process", "improved", "innovation", "model design", "mortality", "novel", "pandemic disease", "patient outreach", "physical conditioning", "psychosocial", "racial minority population", "secondary outcome", "uptake", "vaccine acceptance" ], "approved": true } }, { "type": "Grant", "id": "11918", "attributes": { "award_id": "5R01DA054956-02", "title": "Crisis Response, Durable Lessons: A Mixed Methods Examination of a Large-Scale Hoteling Intervention for People Experiencing Homelessness During the COVID-19 Pandemic", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21691, "first_name": "CARRIE FRIED", "last_name": "Mulford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-15", "end_date": "2027-06-30", "award_amount": 769479, "principal_investigator": { "id": 22634, "first_name": "Kelly", "last_name": "Doran", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "11919", "attributes": { "award_id": "5R01HL159711-08", "title": "hHv1 channels in neutrophils and the innate immune inflammatory response", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22454, "first_name": "GUOFEI", "last_name": "Zhou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-05", "end_date": "2026-06-30", "award_amount": 600649, "principal_investigator": { "id": 25632, "first_name": "Steve A N", "last_name": "Goldstein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 25633, "first_name": "Ruiming", "last_name": "Zhao", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "SUMMARY/ABSTRACT (30 lines) Relevance to public health. Polymorphonuclear leukocytes (PMN, neutrophils) release reactive oxygen species (ROS) to combat infection, but this inflammatory response can also initiate and propa- gate lung damage. Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS) that is fatal in 40% of patients, are characterized by accumulation of albumin-rich fluid in the pulmonary air spaces. Drug therapies focused on downstream cytokine actions have failed to improve morbidity or mortality; we hypothesize, and offer evidence, that targeting the human voltage-gated pro- ton channel (hHv1) at early steps can be more effective. We propose to target hHv1 because (i) the chan- nel in PMN initiates and sustains the inflammatory response, (ii) C6, a unique blocker of hHv1 sup- presses human PMN ROS production, and (iii) C6 suppresses lung compromise in an ALI mouse model. Brief background. This application builds on advances in the last period when we created the first high-affinity and specific direct blocker of hHv1 (C6 peptide) and used it to show, first, that human sperm require hHv1-mediated H+ efflux to initiate capacitation, allowing the acrosomal reaction, and oocyte fertilization and, second, that hHv1 in human PMN is required to produce and sustain release of inflammatory agents, including ROS and proteases, during the innate immune inflammatory response. Unique features and innovation. Our pilot data reveal a second target in the pathway: albumin (Alb) is required to activate hHv1 in human PMN and we describe a peptide (L*) that blocks Alb-activa- tion and ROS production. Supporting our driving hypothesis, we show here that both C6 and L* inhibit hHv1 in human PMN, decreasing ROS production, and that C6 protects in an ALI mouse model, restor- ing lung compliance, and decreasing ROS, proinflammatory cytokines, protein, and PMN in bron- choalveolar lavage fluid. We employ our novel membrane tethered (T-peptide) method to speed struc- ture-function studies and peptide design, show a bivalent C6 (C62) that fully inhibits open hHv1 chan- nels, benefit from advanced biophysical and in vivo methods, and two expert collaborators. Three specific aims. (1) Alb activation of hHv1 seeks the structural and mechanistic basis for the action of Alb and a more potent natural metabolite. (2) Alb regulation of the PMN inflammatory re- sponse seeks to delineate the role of hHv1 in PMN using C6, C62 and L* and the basis for peptide action. (3) Inhibiting acute lung injury with Hv1 inhibitors studies an ALI model in WT and Hv1 KO mice. Significance. This work addresses an unmet medical need, recently made more apparent by the ad- vent of COVID-19-related ALI/ARDS and has broader influence because Hv1 in PMN and other phago- cytes is complicit in additional acute and chronic inflammatory disorders. We propose to apply unique hHv1 inhibitors and innovative methods to understand and suppress this pathophysiology.", "keywords": [ "Acrosome Reaction", "Acute", "Acute Lung Injury", "Acute Respiratory Distress Syndrome", "Address", "Affinity", "Air", "Albumins", "Anti-Inflammatory Agents", "Automobile Driving", "Bacteria", "Bacterial Pneumonia", "Binding", "Biophysics", "Bronchoalveolar Lavage Fluid", "COVID-19", "COVID-19 pandemic", "Cells", "Cessation of life", "Chronic", "Complex", "Data", "Development", "Disease", "Effectiveness", "Elastases", "Fertilization", "Fluorescence Resonance Energy Transfer", "Functional disorder", "Generations", "Goals", "Grant", "Health", "Hospitalization", "Host Defense", "Human", "Hypoxemia", "Immune", "Immunization", "In Vitro", "Infection", "Inflammation", "Inflammation Mediators", "Inflammatory", "Inflammatory Response", "Innate Immune System", "Ischemic Stroke", "Knock-out", "Knockout Mice", "Leukocytes", "Life", "Ligands", "Liquid substance", "Lung", "Lung Compliance", "Mediating", "Medical", "Membrane", "Methods", "Microscopy", "Modeling", "Morbidity - disease rate", "Mus", "Oocytes", "Oxidants", "Oxidases", "Pathology", "Pathway interactions", "Patients", "Peptide Hydrolases", "Peptides", "Phagocytes", "Pharmaceutical Preparations", "Pharmacology", "Pharmacology Study", "Pharmacotherapy", "Physiology", "Pneumonia", "Production", "Proteins", "Protons", "Public Health", "Publishing", "Reactive Oxygen Species", "Regulation", "Reporting", "Research", "Respiratory Burst", "Role", "SARS-CoV-2 infection", "Sepsis", "Site", "Speed", "Sperm Capacitation", "Structure", "Variant", "Virus", "Wild Type Mouse", "Work", "base", "chronic inflammatory disease", "combat", "cytokine", "design", "experience", "extracellular", "fungus", "improved", "in vivo", "inhibitor", "innovation", "lung injury", "mortality", "mouse model", "neutrophil", "novel", "novel strategies", "operation", "pharmacologic", "public health relevance", "rational design", "response", "single molecule", "sperm cell", "structural biology", "success", "tool", "voltage" ], "approved": true } }, { "type": "Grant", "id": "11920", "attributes": { "award_id": "5R25GM146236-03", "title": "Tomorrow's Science Today: Preparing for the Next Pandemic", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-11", "end_date": "2027-06-30", "award_amount": 237833, "principal_investigator": { "id": 10612, "first_name": "Tim M.", "last_name": "Herman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1090, "ror": "https://ror.org/04h7cfr36", "name": "Milwaukee School of Engineering", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 2034, "ror": "", "name": "3D MOLECULAR DESIGNS", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "This project – Tomorrow’s Science Today: preparing for the next pandemic – will create a professional development experience for high school science teachers focused on infectious diseases and the molecular technologies that are being used to control them. The project consists of two distinct phases. In the first, we will create a variety of hands-on instructional materials – composed of both foam-based schematic models and accurate 3D-printed models of proteins – to bring to life molecular stories of the process of science. We will use a framework that emphasizes how the foundational concepts of molecular biology established in the past (Yesterday’s Science) provides the basis for the amazing technology that has been brought to bear on the current SARS-Cov-2 pandemic (Today’s Science) and also lays the ground-work for even more powerful defenses in the future (Tomorrow’s Science). In the second phase of this project, we will create a professional learning experience in which the project’s instructional materials will be introduced to high school science teachers. The project’s goals are (i) to increase the teachers’ content knowledge regarding the molecular mechanisms of infectious diseases and (ii) to model for the teachers a student-centered active learning pedagogy that values questions over answers. The project features a formal teacher empowerment program in which a small group of veteran teachers are trained to serve as mentors for teachers who are new to the project. High school biology and chemistry teachers will be recruited into this project via presentations and exhibits at state, regional and national meetings of science educators. A plan is in place to proactively accept teachers from schools with a significant population of underserved minority students. And finally, the broad dissemination of the project’s instructional materials will be achieved through our established partnerships with other science outreach organizations whose programs focus on URM students in urban Milwaukee, Chicago and rural Nebraska and South Dakota.", "keywords": [ "3D Print", "Active Learning", "Amaze", "Basic Science", "Biology", "COVID-19 pandemic", "Chemistry", "Chicago", "Communicable Diseases", "Coronavirus", "Development", "Disease Outbreaks", "Exhibits", "Future", "Goals", "Health", "High School Student", "Infrastructure", "Investments", "Knowledge", "Learning", "Life", "Modeling", "Molecular", "Molecular Biology", "Nebraska", "Outcome", "Phase", "Play", "Process", "Proteins", "Research", "Role", "Rural", "School Teachers", "Science", "Series", "South Dakota", "Students", "Teacher Professional Development", "Technology", "Underserved Population", "Vaccines", "Veterans", "Virus", "empowerment", "experience", "future pandemic", "hands on instruction", "high school", "learning materials", "meetings", "minority student", "outreach", "pedagogy", "program dissemination", "programs", "recruit", "science teacher", "teacher", "teacher mentor", "underrepresented minority student", "viral pandemic" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1419, "count": 14184 } } }