Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=end_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=end_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=end_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=end_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=end_date" }, "data": [ { "type": "Grant", "id": "9663", "attributes": { "award_id": "1IK6CX002519-01", "title": "CSRD Research Career Scientist Award Application", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-04-01", "end_date": "2029-03-31", "award_amount": null, "principal_investigator": { "id": 22671, "first_name": "Judith M", "last_name": "Ford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1522, "ror": "", "name": "VETERANS AFFAIRS MED CTR SAN FRANCISCO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1522, "ror": "", "name": "VETERANS AFFAIRS MED CTR SAN FRANCISCO", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Dr. Ford is an established investigator in neuroscience and psychiatry, with a PhD in neuroscience and life-long appointments in mental health/psychiatry. She uses electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), to investigate the neurobiology of schizophrenia (SZ) and major depressive disorder (MDD). And now, she is adding COVID19 “long haulers” to the conditions she studies with brain imaging methods. SZ. Dr. Ford’s work in SZ was focused on an elemental neural system that dampens neural responses to self- generated stimuli compared to stimuli arising from the environment. It is thought to reflect the operation of an efference copy/corollary discharge mechanism involving signaling from motor to sensory regions, preparing sensory regions for self-generated sensory events. This mechanism is ubiquitous across all animal species, and her work in translating this mechanism to a human paradigm has uncovered a fundamental deficit in sensory information processing in people on the psychosis spectrum. With NIH R01 funding, she has shown deficiencies in these mechanisms are linked to auditory hallucinations and delusions. With current NIH R03 funding, she is now asking about the role of the thalamo-pontine-cerebellar circuit in the successful operation of this system. Two of Dr. Ford’s VA trainees are now extending this work to a new sample of people with psychosis, their 1st degree relatives, youth at clinical risk for developing psychosis, and non-affected control participants. They are finding connectivity between cerebellum and pons is related to the action of the efference copy/corollary discharge mechanism. With a more recently funded NIH R03 grant, she is asking whether EEG-assessed slowed perception has upstream effects on cognition and contributes to clinical features of psychosis in the schizophrenia spectrum. With a to-be-funded mechanistic clinical trial (NIH R21) involving a VA psychiatrist, a VA radiologist, and a UCSF cardiologist, she is asking whether a ketogenic diet can restore neural network stability in SZ, thereby addressing both cognitive deficits and metabolic syndrome, associated with poor function and a shortened life span, respectively. MDD/SZ. About 4 years ago, she added MDD to the clinical populations she studies and is asking about the negative consequences of rumination and whether they can be rescued by a mindfulness approach to life. Rumination is an internal cognitive state characterized by recursive thinking of self-distress and negative events focusing on the causes and consequences of distress rather than solutions. It cuts across diagnostic boundaries: It is associated with symptom severity and chronicity in both MDD and SZ. Mindfulness is associated with less distress from auditory hallucinations in SZ and fewer residual symptoms in MDD. It involves attending to present moment experiences and sensations and allowing emotions and thoughts to enter and leave consciousness without judgment, thereby avoiding a downward spiral into rumination. Compared to simple mind wandering, mindfulness recruits an attention network including parietal and prefrontal structures while mind wandering only recruits the default mode network. Long-COVID19. The newest population she is studying is the so-called ‘long-haulers’ following COVID19 infection. While the lungs are ground zero, COVID19 tears through organ systems from brain to blood vessels. Some who recover complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. Dr. Ford has joined forces with both Lab Medicine and Radiology at SFVAMC to use psychological testing, neuroimaging methods, and markers in the blood signaling damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of “COVID brain” and prepare for down-stream problems.", "keywords": [ "Address", "Advocate", "American", "Anesthesiology", "Animals", "Anxiety", "Appointment", "Asthma", "Attention", "Auditory", "Auditory Hallucination", "Award", "Behavioral Sciences", "Biological Markers", "Biological Psychiatry", "Blood", "Blood Vessels", "Brain", "Brain imaging", "COVID-19", "COVID-19 complications", "COVID-19 impact", "COVID-19 long hauler", "COVID-19 survivors", "Cerebellum", "Chronic", "Clinical", "Clinical Medicine", "Clinical Trials", "Cognition", "Cognitive", "Cognitive deficits", "Collaborations", "Congresses", "Conscious", "Delusions", "Diagnostic", "Diet", "Distress", "Doctor of Philosophy", "Educational process of instructing", "Electroencephalography", "Emotions", "Environment", "Esthesia", "Event", "Family", "First Degree Relative", "Foundations", "Functional Magnetic Resonance Imaging", "Functional disorder", "Funding", "Grant", "Group Meetings", "Hallucinations", "Human", "Hypertension", "International", "Judgment", "Ketones", "Leadership", "Learning", "Life", "Link", "Long COVID", "Longevity", "Lung", "Magnetic Resonance Imaging", "Major Depressive Disorder", "Malignant Neoplasms", "Medicine", "Mental Depression", "Mental Health", "Mentors", "Metabolic syndrome", "Methods", "Mind", "Mindfulness Training", "Morbidity - disease rate", "Motor", "Neurobiology", "Neurosciences", "Obesity", "Parietal", "Participant", "Patients", "Perception", "Persons", "Phase", "Physicians", "Pontine structure", "Population", "Psychiatrist", "Psychiatry", "Psychological Tests", "Psychologist", "Psychoses", "Radiologic Health", "Radiology Specialty", "Research", "Research Personnel", "Residual state", "Review Committee", "Role", "SARS-CoV-2 infection", "Sampling", "Schizophrenia", "Scientist", "Sensory", "Severities", "Signal Transduction", "Smoking", "Societies", "Stimulus", "Structure", "Symptoms", "System", "Talents", "Thinking", "Time", "Translating", "United States National Institutes of Health", "Veterans", "Work", "Youth", "body system", "brain behavior", "career", "clinical risk", "clinically significant", "college", "coronavirus disease", "cost", "deficit syndrome", "disability", "editorial", "experience", "high risk", "imaging modality", "imaging study", "information processing", "ketogenic diet", "long term consequences of COVID-19", "meetings", "member", "mindfulness", "mortality", "neural network", "neuroimaging", "neuropsychopharmacology", "operation", "programs", "radiologist", "recruit", "rela" ], "approved": true } }, { "type": "Grant", "id": "14583", "attributes": { "award_id": "1R25AI181750-01", "title": "HBCU/MSI Mentored Research Program in the Structural Biology of Human Pathogens", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 31247, "first_name": "MADELYN", "last_name": "Reyes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-08", "end_date": "2029-03-31", "award_amount": 339012, "principal_investigator": { "id": 31248, "first_name": "Jamaine S", "last_name": "Davis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 938, "ror": "https://ror.org/00k63dq23", "name": "Meharry Medical College", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "Meharry Medical College is continuing its mission in training underrepresented minority students for diseases that disproportionately impact underserved communities. As the COVID-19 pandemic has highlighted, infectious diseases continue to cause a global humanitarian and economic burden. The most effective way to combat the continued emergence of infectious diseases is to have a robust drug development pipeline at the ready. The training for scientists in this drug development pipeline to combat infectious diseases needs to include structural biology and students traditionally underrepresented in biomedical sciences. To strengthen professional and scientific skills to enhance scientific productivity, particularly in the field of structural biology of human pathogens, novel programs, such as the one proposed are needed. The proposed HBCU/MSI Mentored Research Program in the Structural Biology of Human Pathogens is a 10- week summer program will provide an intensive, hands-on research experience for students (community college, undergraduate, medical) that will deliver training and education in the structural biology of infectious disease proteins. Research training will be provided by a diverse faculty consisting of experienced structural biology investigators from Meharry Medical College and Vanderbilt University Medical Center. A nationwide search will be conducted to select 10-16 students per year who are interested in pursuing careers in medicine and biomedical science related to NIAID. Student research projects will focus on structures on human pathogens, provide by our partnership with Seattle Structural Genomics Center for Infectious Diseases (SSGCID). Student education will encompass the fundamentals of structural biology provided in a mini-course and mentored through the solving of protein structures. This exciting and innovative program will give each student participant the full workflow of solving a protein structure from prediction to expression all the way through to structure determination and publication. As a collaborator, Black In Biophysics will assign a Career Mentor to each participant and students will participate in career development workshops to explore career options, create individual development plans, and obtain information needed to apply and successfully gain entrance into Ph.D. and M.D. training programs. At the end of the 10-week program, students will have an opportunity to create oral and poster presentations describing their research and present their research findings internally during the Summer Research Symposium and externally at one national conference. Program directors and staff will track participants through their undergraduate/medical and post graduate training to evaluate the extent to which program goals were met and identify areas for improvement. Evaluations from research mentors and program directors/chairs will also be used to assess and improve the program.", "keywords": [ "3-Dimensional", "Academia", "Academic Medical Centers", "Area", "Authorship", "Biomedical Research", "Biophysics", "Black race", "COVID-19", "COVID-19 impact", "COVID-19 pandemic", "Cessation of life", "Communicable Diseases", "Computer software", "Crystallization", "Data", "Data Collection", "Development", "Development Plans", "Disease", "Doctor of Medicine", "Doctor of Philosophy", "Economic Burden", "Education", "Educational process of instructing", "Educational workshop", "Ethnic Population", "Evaluation Research", "Faculty", "Funding", "Genomic Centers for Infectious Diseases", "Global Awareness", "Goals", "Historically Black Colleges and Universities", "Individual", "Industry", "Infectious Agent", "Journals", "Medical", "Medicine", "Mentors", "Mentorship", "Microbiology", "Mission", "National Institute of Allergy and Infectious Disease", "Oral", "Participant", "Play", "Production", "Productivity", "Program Evaluation", "Protein Biochemistry", "Proteins", "Protocols documentation", "Public Health", "Publications", "Publishing", "Research", "Research Personnel", "Research Project Grants", "Research Training", "Roentgen Rays", "Schools", "Science", "Science Technology Engineering and Mathematics", "Scientist", "Societies", "Structural Biochemistry", "Structural Biologist", "Structure", "Students", "Therapeutic", "Training", "Training Programs", "Training and Education", "Underrepresented Minority", "Work", "X-Ray Crystallography", "career", "career development", "combat", "community college", "course development", "data structure", "design", "drug development", "experience", "future outbreak", "hands on research", "human pathogen", "improved", "innovation", "interest", "lectures", "medical schools", "member", "next generation", "novel", "novel therapeutics", "posters", "prevent", "programs", "protein structure", "protein structure prediction", "racial population", "recruit", "skills", "structural biology", "structural genomics", "summer program", "summer research", "symposium", "three dimensional structure", "undergraduate student", "underrepresented minority student", "underserved community", "virtual", "virtual platform" ], "approved": true } }, { "type": "Grant", "id": "14597", "attributes": { "award_id": "1K23NS133488-01A1", "title": "Magnetic Resonance Imaging Biomarkers of Post-COVID-19 Cerebral Microvascular Dysfunction", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 6896, "first_name": "WILLIAM PATRICK", "last_name": "Daley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-15", "end_date": "2029-03-31", "award_amount": 231524, "principal_investigator": { "id": 31268, "first_name": "Lindsay", "last_name": "McAlpine", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 452, "ror": "https://ror.org/03v76x132", "name": "Yale University", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "Neurologic post-acute sequelae of SARS-CoV-2 infection (neuro-PASC) is a pressing public health issue and little is known about the cause, duration, and potential treatments. It is defined as a new health problem occurring three months after initial COVID infection and lasting for at least two months. Common symptoms of neuro- PASC include headache, inattention, cognitive impairment, dizziness, insomnia, and mood changes. Emerging evidence suggests that persistent microvascular inflammation and dysfunction play critical roles in the PASC of the lungs and heart. Numerous post-mortem studies have demonstrated significant microvascular damage and dysfunction in the brains of individuals who have died of acute COVID-19. In the brains of individuals living with neuro-PASC, case-control studies have found microvascular dysfunction, cerebral hypoperfusion, and new small vessel disease. The long-term neurologic effects of microvascular dysfunction and subsequent risk of vascular dementia is unknown. I hypothesize that cerebral microvascular dysfunction plays a critical role in neuro- PASC cognitive impairment and puts individuals at risk for progression of small vessel disease. Here, I propose utilizing advanced vascular MRI techniques to investigate for biomarkers of microvascular dysfunction in the brain to better understand the pathophysiology of neuro-PASC and risk for progression of small vessel disease. Understanding the underlying disease process will bring us closer to identifying biomarkers and treatment targets. In order to enrich the probability of finding MRI alterations, I will recruit participants with cognitive impairment, which is the most common and well-documented neuro-PASC symptom. I will conduct a longitudinal study and perform two sets of MRIs, blood tests, and neuropsychological tests on each participant. I will recruit at least 50 adults with a documented COVID-19 infection and cognitive symptoms and compare them to 50 adults with a documented COVID-19 infection and no residual symptoms (controls). My detailed MRI protocol will evaluate the vessel wall, arterial, and venous vasculature and explore techniques to map the lymphatic vasculature. In the blood, I will test markers of coagulopathy, endotheliopathy, and neurodegeneration. I am a neurologist and physician-scientist who has developed clinical and scientific expertise in neuro-PASC through caring for patients in the NeuroCOVID Clinic at Yale, and I am working in the neuro-infectious disease laboratory of my primary mentor. I recently graduated from fellowship, and I am now an Instructor in the Department of Neurology. My long-term goal is to become an independent clinician-scientist with a focus on utilizing neuroimaging techniques to understand the pathophysiology of neuro-PASC and generate biomarkers of disease and treatment targets. To accomplish this goal, I have assembled a world class mentorship team with experts in neuroradiology, neuropsychology, and neuro-ID. I will take advanced coursework in neuroimaging, statistics, and vascular biology. The completion of this mentored award will prepare me to become an independent physician-scientist and allow me to make meaningful contributions to the field and to patient care.", "keywords": [ "Adult", "Atrophic", "Autopsy", "Award", "Biological Markers", "Biology", "Blood", "Blood Coagulation Disorders", "Blood Platelets", "Blood Tests", "Blood Vessels", "Brain", "COVID-19", "Cardiovascular system", "Case Series", "Case/Control Studies", "Cerebrum", "Clinic", "Clinical", "Cognition", "Cognitive", "Cognitive deficits", "Data", "Diffusion", "Disease", "Dizziness", "Endothelium", "Enrollment", "Exhibits", "Fellowship", "Functional disorder", "Future", "Goals", "Headache", "Health", "Heart", "Image", "Impaired cognition", "Individual", "Inflammatory", "Ischemic Stroke", "Laboratories", "Language", "Link", "Long-Term Effects", "Longitudinal Studies", "Lung", "Lymph Node Mapping", "Magnetic Resonance Imaging", "Memory", "Mental Health", "Mentors", "Mentorship", "Microvascular Dysfunction", "Mind", "Moods", "Morbidity - disease rate", "Motor", "Nerve Degeneration", "Neurobehavioral Manifestations", "Neurologic Effect", "Neurologist", "Neurology", "Neuropsychological Tests", "Neuropsychology", "Participant", "Pathology", "Patient Care", "Patient Recruitments", "Patients", "Perception", "Perfusion", "Persons", "Physicians", "Pilot Projects", "Play", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Probability", "Process", "Protocols documentation", "Public Health", "Publishing", "Reporting", "Residual state", "Risk", "Role", "SARS-CoV-2 infection", "Scientist", "Severities", "Short-Term Memory", "Sleeplessness", "Symptoms", "Techniques", "Testing", "Time", "Training", "Vascular Dementia", "Vascular Diseases", "Venous", "Visit", "acute COVID-19", "biomarker identification", "cerebral hypoperfusion", "common symptom", "comparison control", "endothelial dysfunction", "high risk", "hypoperfusion", "inattention", "insight", "instructor", "lymphatic vasculature", "magnetic resonance imaging biomarker", "mortality", "neuroimaging", "neurologic sequelae of COVID-19", "neuropsychiatry", "post-COVID-19", "primary outcome", "progression risk", "recruit", "research study", "statistics", "vascular inflammation" ], "approved": true } }, { "type": "Grant", "id": "14598", "attributes": { "award_id": "1R01MH133230-01", "title": "Digital Implementation Support to Achieve Uptake and Integration of Task-Shared Care for Schizophrenia in Primary Care in India", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 31269, "first_name": "Vidya", "last_name": "Vedham", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-01", "end_date": "2029-03-31", "award_amount": 817815, "principal_investigator": { "id": 31270, "first_name": "Narayana", "last_name": "Manjunatha", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 23341, "first_name": "John", "last_name": "Torous", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 771, "ror": "https://ror.org/04drvxt59", "name": "Beth Israel Deaconess Medical Center", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, { "id": 31271, "first_name": "John A", "last_name": "Naslund", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 855, "ror": "", "name": "HARVARD MEDICAL SCHOOL", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Schizophrenia is a significant contributor to the global burden of disease. In India, this burden is further exacerbated because individuals living with schizophrenia have limited access to effective psychosocial interventions aimed at promoting recovery, rehabilitation, and community tenure, while there is inadequate attention to managing co-occurring chronic medical conditions that result in significantly reduced life expectancy among this patient group compared to the general population. There now exists strong evidence demonstrating that community programs delivered in primary care and leveraging psychosocial interventions combined with linkage to specialty psychiatric services are effective for supporting treatment and recovery of schizophrenia in low-resource settings. Therefore, there is an urgent need to integrate these effective programs into existing non-communicable disease care services delivered in primary care settings towards scaling up community care for schizophrenia. With the accelerated adoption of digital technologies in the health system in India, driven by the COVID-19 pandemic, there are new opportunities to leverage these digital devices to coordinate care delivery for complex conditions such as schizophrenia. We propose to capitalize on this newly established digital infrastructure to support the integration of task-shared care for schizophrenia and allow monitoring of mental health, physical health, and functional outcomes over time. Specifically, we propose to train and supervise frontline health workers tasked primarily with addressing chronic health conditions in community settings in the delivery of an evidence-based psychosocial rehabilitation program for schizophrenia called the Community Care for People with Schizophrenia in India (COPSI). We will leverage our existing collaboration and robust research infrastructure in both rural and urban settings in Madhya Pradesh and Karnataka, India to conduct a hybrid type 1 effectiveness-implementation trial to evaluate whether use of a digital platform offers added clinical benefit and can support integration of this task shared care for schizophrenia into routine primary care settings. We will conduct an individual randomized controlled trial enrolling 240 adults with schizophrenia to evaluate whether use of the mindLAMP digital platform can enhance the clinical effectiveness of the COPSI program in reducing disability for individuals living with schizophrenia. We will also measure a range of secondary outcomes for physical health and lifestyle behaviors linked to early mortality, and mental health. We will also determine whether the addition of mindLAMP to the delivery of the COPSI program has an impact on implementation metrics when compared to delivery of COPSI alone. Our study directly supports NIMH RFA-MH-22-130 by seeking to evaluate whether a novel digital platform can support the clinical effectiveness and integration of a proven psychosocial rehabilitation intervention for schizophrenia into the ongoing national roll out of comprehensive NCD services in primary care in India.", "keywords": [ "Acceleration", "Address", "Adoption", "Adult", "Attention", "Behavior", "COVID-19 pandemic", "Caring", "Chronic", "Clinical", "Clinical effectiveness", "Collaborations", "Communities", "Community Health", "Community Healthcare", "Complex", "Cost Analysis", "Data", "Devices", "Disease", "General Population", "Government", "Health", "Health Services Accessibility", "Health system", "Hybrids", "India", "Individual", "Infrastructure", "Intervention", "Life Expectancy", "Life Style", "Link", "Measures", "Mediator", "Medical", "Mental Health", "Monitor", "National Institute of Mental Health", "Outcome", "Patient Participation", "Patient-Focused Outcomes", "Patients", "Persons", "Primary Care", "Randomized", "Randomized Controlled Trials", "Recovery", "Rehabilitation therapy", "Research Infrastructure", "Resource-limited setting", "Schizophrenia", "Services", "Supervision", "Symptoms", "Testing", "Time", "Training", "arm", "burden of illness", "care coordination", "care delivery", "care systems", "community setting", "cost", "digital", "digital data", "digital intervention", "digital phenotyping", "digital platform", "digital technology", "disability", "effective intervention", "effectiveness/implementation trial", "evidence base", "functional outcomes", "gaps in access", "implementation outcomes", "low and middle-income countries", "medical specialties", "mortality", "novel", "novel strategies", "patient engagement", "patient population", "physical conditioning", "primary care setting", "programs", "psychosocial", "psychosocial rehabilitation", "rural setting", "scale up", "secondary outcome", "trial enrollment", "uptake", "urban setting" ], "approved": true } }, { "type": "Grant", "id": "14602", "attributes": { "award_id": "1R01AA030890-01A1", "title": "Trajectories of Isolation and (A)Loneliness with AOD Use, 2019-2027: A National Egocentric Network Study of US Adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)", "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 6068, "first_name": "I-Jen", "last_name": "Castle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-01", "end_date": "2029-03-31", "award_amount": 637163, "principal_investigator": { "id": 20561, "first_name": "MICHAEL SEAN", "last_name": "POLLARD", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 515, "ror": "https://ror.org/00f2z7n96", "name": "RAND Corporation", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 515, "ror": "https://ror.org/00f2z7n96", "name": "RAND Corporation", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "This project will significantly advance understanding of the longitudinal links between social connection, alcohol, cannabis, and other drug (AOD) use through the analysis of novel longitudinal data that includes a multidimensional assessment of social connection over eight consecutive years. There are well-established links between isolation, loneliness and all-cause mortality and morbidity, but longitudinal study of the links between social connection and health behaviors, which may represent a primary pathway linking to mortality, is relatively sparse due to the lack of longitudinal data. This project will explore multiple aspects of social connection for adults ages 30-80: social isolation, loneliness, and the relatively new concept of aloneliness. Isolation is assessed using novel egocentric network data and standard isolation measures. Loneliness and aloneliness are assessed using validated scales. Mental well-being is implicated as a mediating link between social connection and health behaviors and is assessed though depression and anxiety. This study will generate the largest longitudinal data on adult social connection and AOD use. The fields of substance research and prevention may see substantial benefit from this project’s use of novel methodological techniques to develop longitudinal models elucidating the ways in which adult social connection is linked to AOD use. Specifically, We will: 1) examine the cumulative, interactive, and reciprocal effects of multiple dimensions of social connectedness with substance use (accounting for mental well-being), before, and during peak and during late COVID-19 pandemic, which likely deeply impacted adult social connection; 2) examine the role of network churn, network structure, and network AOD use on social connectedness and individual AOD use, as well as predictors of churn and structure, in peak and late pandemic periods; and 3) will explore potential disparities by age, by gender, and by race/ethnicity in the associations of SI/L/A, network characteristics, and AOD use, all of which have been understudied in the social connection literature. To do so, we will extend and expand an existing nationally representative sample of 1,771 adults ages 30-80 (at 2019 baseline), collected by the same team, with four additional annual waves of data, resulting in 10 waves of data from 2019-2027 for all key measures, and expanded measures 2024- 2027. We will primarily apply innovative multivariate latent growth models with structured residuals methods, which estimate 2+ latent growth models at the same time while simultaneously estimating and disentangling between- and within- persons variability over time. Moreover, this model allows for the estimation of reciprocal relations among outcomes and mediated (indirect) paths, at the within- persons level; in this case trajectories of AOD use and multiple aspects of social connections.", "keywords": [ "Accounting", "Adult", "Age", "Alcohol consumption", "Alcoholic beverage heavy drinker", "Alcohols", "Anxiety", "Behavior", "COVID-19 pandemic", "Cannabis", "Characteristics", "Communities", "Data", "Data Set", "Dimensions", "Disparity", "Distress", "Drug usage", "Ethnic Origin", "Family", "Friends", "Funding", "Gender", "Growth", "Health behavior", "Individual", "Lifting", "Link", "Literature", "Loneliness", "Longitudinal Studies", "Measures", "Mediating", "Mental Depression", "Mental Health", "Methodology", "Methods", "Modeling", "Morbidity - disease rate", "National Institute on Alcohol Abuse and Alcoholism", "Outcome", "Pathway interactions", "Personal Satisfaction", "Persons", "Pharmaceutical Preparations", "Phase", "Play", "Policies", "Population", "Populations at Risk", "Prevention", "Privacy", "Probability", "Race", "Relaxation", "Reporting", "Research", "Residual state", "Respondent", "Role", "Sampling", "Social Controls", "Social Distance", "Social Environment", "Social Network", "Social isolation", "Social support", "Structure", "Surgeon", "Surveys", "Techniques", "Time", "Well in self", "Work", "alcohol and other drug", "alcohol consequences", "binge drinking", "craving", "design", "deviant", "drinking", "ethnic minority", "experience", "improved", "indexing", "innovation", "mortality", "mortality risk", "novel", "pandemic disease", "physical conditioning", "pre-pandemic", "racial minority", "satisfaction", "social", "social norm", "social relationships", "sociodemographics", "substance use", "young adult" ], "approved": true } }, { "type": "Grant", "id": "14607", "attributes": { "award_id": "1R01AI177696-01A1", "title": "Discovery of Antivirals Targeting Mpox Virus", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 10523, "first_name": "Mindy I.", "last_name": "Davis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-08", "end_date": "2029-03-31", "award_amount": 703928, "principal_investigator": { "id": 31278, "first_name": "HAIAN", "last_name": "FU", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22933, "first_name": "Raymond Felix", "last_name": "Schinazi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, { "id": 25671, "first_name": "Stefan G", "last_name": "Sarafianos", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The World Health Organization (WHO) declared Mpox (MPX) a global health emergency in 2022 and in the United States, MPX was declared a Public Health Emergency with >30,500 cases confirmed so far. MPX is a zoonotic infectious disease caused by the orthopoxvirus Mpox virus (MPXV), which is related to the virus that causes smallpox. Vaccination against smallpox offers protection against MPXV; however, routine smallpox vaccination ended in 1972 in US and 1984 world-wide following the successful global eradication of smallpox in 1979. Hence, most of the world’s population is highly vulnerable. In March-June 2023, 40 Mpox cases were identified in Chicago, including many vaccinated patients, suggesting decreased vaccine effectiveness. There are currently no FDA-approved drugs for MPX. There is an Expanded Access Investigational New Drug (EA-IND) Protocol for use of tecovirimat (TPOXX), which targets VP37, a viral protein involved in the envelopment of intracellular mature virus. Cidofovir (CDV) and its lipid pro-drug brincidofovir have been reported to also inhibit multiple orthopoxviruses, albeit with reduced potency relative to their activity against herpesviruses. There are several reports that establish that the barriers to resistance for TOPXX and CDV are low. Hence, there is a lack of efficacious, well-tolerated drugs that can be broadly used for the treatment and prevention of MPXV infections. To address this public health challenge our multidisciplinary team will extend long standing collaborative efforts on other infectious diseases towards the discovery of innovative antivirals that target MPXV. This strategy is designed to leverage exceptional expertise in drug discovery, nucleoside chemistry, assay development, screening technologies, and mechanism of action studies, augmented by the expertise at the CDC. We hypothesize that direct antiviral agents (DAA) against MPXV can be efficiently discovered through informative assays for high throughput screening (HTS) and high content screening (HCS) and validated, thus leading into downstream lead candidate development. To address this hypothesis, we propose experiments that address the following aims: Specific Aim 1. To further develop and optimize antiviral assays Specific Aim 2. To implement screening campaigns for the discovery of low cytotoxicity antiviral hits Specific Aim 3. To determine the mechanisms of action and resistance (MOA and MOR) of select hits Specific Aim 4. To optimize potent, broad-spectrum, non-cytotoxic hits and identify a clinical candidate Given the team’s preliminary data, outstanding expertise, access to world-class state-of-the-art screening facilities (including BSL-3 labs), and the contributions to development of drugs for the treatment of HIV, HBV, HCV, and SARS-CoV-2 in humans, we expect to generate compound leads that can progress rapidly to advanced preclinical development.", "keywords": [ "2019-nCoV", "Address", "Africa", "Anti-viral Agents", "Attenuated", "Binding Sites", "Biological Assay", "Biology", "Case Study", "Cell Culture Techniques", "Cells", "Centers for Disease Control and Prevention (U.S.)", "Central Africa", "Chemicals", "Chemistry", "Chicago", "Cidofovir", "Clinical", "Collection", "Communicable Diseases", "Containment", "Country", "Cytomegalovirus", "DNA-Directed RNA Polymerase", "Data", "Development", "Disease Outbreaks", "Dose", "Drug Targeting", "Engineering", "FDA approved", "Future", "Gene Targeting", "Goals", "Golgi Apparatus", "HIV", "HIV Seropositivity", "Hepatitis B Virus", "Hepatitis C virus", "Herpesviridae", "Human", "Immunodiagnostics", "Investigational Drugs", "Lead", "Libraries", "Ligands", "Lipids", "Membrane", "Modified Vaccinia Virus Ankara", "Monkeypox", "Nucleosides", "Orthopoxvirus", "Pathology", "Patients", "Pharmaceutical Chemistry", "Pharmaceutical Preparations", "Pharmacology", "Pharmacotherapy", "Population", "Poxviridae", "Prevention", "Process", "Prodrugs", "Proteomics", "Protocols documentation", "Public Health", "Reporter", "Reporting", "Resistance", "Ribonucleosides", "Safety", "Simplexvirus", "Smallpox", "Speed", "Structure", "Structure-Activity Relationship", "Technology", "Tenofovir", "Testing", "Therapeutic", "United States", "United States Food and Drug Administration", "Vaccination", "Vaccinee", "Vaccines", "Vaccinia virus", "Validation", "Viral", "Viral Genes", "Viral Proteins", "Virus", "Virus Diseases", "Virus Inhibitors", "Virus Replication", "World Health Organization", "Zoonoses", "adefovir", "analog", "assay development", "clinical candidate", "community transmission", "cytotoxicity", "data submission", "design", "drug development", "drug discovery", "drug repurposing", "experimental study", "global health emergency", "high risk population", "high throughput screening", "improved", "innovation", "lead candidate", "meter", "miniaturize", "multidisciplinary", "mutant", "novel therapeutics", "pathogen", "preclinical development", "protein structure", "public health emergency", "resistance mutation", "reverse genetics", "screening", "vaccine effectiveness", "validation studies", "vector", "virology", "virtual screening" ], "approved": true } }, { "type": "Grant", "id": "14627", "attributes": { "award_id": "1R35GM153196-01", "title": "Advancing mechanistic understanding of membrane ion and lipid transport", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22539, "first_name": "Zhongzhen", "last_name": "Nie", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-01", "end_date": "2029-03-31", "award_amount": 503747, "principal_investigator": { "id": 23808, "first_name": "Huanghe", "last_name": "Yang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 246, "ror": "https://ror.org/00py81415", "name": "Duke University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 246, "ror": "https://ror.org/00py81415", "name": "Duke University", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "Dynamic trans-bilayer movement of ions and phospholipids across cell membranes is vital for cellular life and death. In stark contrast to our extensive understanding of membrane ion transport, the mechanisms and consequences of phospholipid flip-flop remain elusive. The TMEM16 transmembrane protein family, implicated in various diseases, such as heart attack, stroke, epilepsy, muscular dystrophy, cancer, and infections like AIDS and COVID-19, comprises both ion channels and lipid scramblases. By closely examining TMEM16 family members, our previous work has eliminated the conceptual barrier between ion channels and lipid scramblases, the two major types of passive transporters on cell membranes cooperating distinct substrates. This conceptual breakthrough has allowed us to determine novel ion and lipid transport principles at the molecular level and uncover new cellular and physiological functions for TMEM16 ion channels and lipid scramblases. In this application, we will investigate TMEM16 lipid scramblases to deepen our understanding of lipid flip-flop and its undiscovered cell signaling roles. We aim to develop innovative methods for monitoring and controlling lipid flip-flop under physiological conditions and to decipher how calcium and voltage activate TMEM16 lipid scramblases at molecular and cellular levels. Additionally, we will employ our novel methods to explore lipid scramblase-mediated cell signaling during cell-cell fusion, an essential yet poorly understood process for human health. Our proposed studies will offer a comprehensive understanding of lipid and ion transport in health and disease, paving the way for developing new therapies to prevent and treat a wide array of diseases, including stroke, heart attack, atherosclerosis, neurological disorders, infectious diseases, and pregnancy complications.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Applications Grants", "Atherosclerosis", "COVID-19", "Calcium", "Cell fusion", "Cell membrane", "Cells", "Cessation of life", "Communicable Diseases", "Development", "Disease", "Epilepsy", "Family member", "Health", "Human", "Infection", "Integral Membrane Protein", "Ion Channel", "Ion Transport", "Ions", "Life", "Lipids", "Malignant Neoplasms", "Mediating", "Membrane", "Membrane Lipids", "Methods", "Molecular", "Monitor", "Movement", "Muscular Dystrophies", "Myocardial Infarction", "Nervous System Disorder", "Phospholipids", "Physiological", "Pregnancy Complications", "Process", "Protein Family", "Role", "Signal Transduction", "Stroke", "Work", "innovation", "lipid transport", "novel", "novel therapeutics", "prevent", "stroke-like outcome", "voltage" ], "approved": true } }, { "type": "Grant", "id": "14636", "attributes": { "award_id": "1P01AI175399-01A1", "title": "Administrative Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2024-04-10", "end_date": "2029-03-31", "award_amount": 122848, "principal_investigator": { "id": 21143, "first_name": "Amal O", "last_name": "Amer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "CORE 1 SUMMARY The overall goal of Administrative Core (Core 1) is to promote the effective integration and management of the different projects and cores in this Program which consists of three research Projects and four shared Cores built around the central research emphasis on SARS-CoV-2 infection and innate immunity. Core 1 will provide leadership, administrative coordination, communication, financial management. Core 1 will also oversee quality control for enhancing research productivity and fostering the development and maintenance of the interactive research environment. Core 1 will provide a coordinated plan to allow the program members to communicate, collaborate, share data, ideas, protocols, results, samples, infectious agents, mouse models, organs, RNAseq data and reagents. It will manage and oversee the fiscal, communications and compliance aspects of this P01. Core 1 will be responsible for the day-to- day management of administrative and budgetary issues of the entire P01.", "keywords": [ "2019-nCoV", "Adaptive Immune System", "Administrative Coordination", "Administrative Personnel", "Blood Coagulation Disorders", "Caspase", "Cell Physiology", "Collaborations", "Communication", "Contracts", "Data", "Development", "Doctor of Philosophy", "Elements", "Ensure", "Environment", "Equipment", "Fostering", "Goals", "Grant", "Infectious Agent", "Inflammasome", "Inflammation", "Innate Immune System", "Investigation", "Lead", "Leadership", "Long COVID", "Maintenance", "Manuscripts", "Mediating", "Medical center", "Morbidity - disease rate", "Natural Immunity", "Occupational activity of managing finances", "Office of Administrative Management", "Organ", "Pathology", "Pathway interactions", "Pediatric Hospitals", "Productivity", "Protocols documentation", "Publishing", "Quality Control", "Reagent", "Research", "Research Project Grants", "Resources", "Role", "SARS-CoV-2 infection", "Sampling", "Statistical Data Interpretation", "Structure", "Thrombosis", "United States National Institutes of Health", "Veterinary Schools", "Work", "conflict resolution", "data management", "data sharing", "design", "distraction", "meetings", "member", "mortality", "mouse model", "preservation", "programs", "response", "severe COVID-19", "transcriptome sequencing" ], "approved": true } }, { "type": "Grant", "id": "14639", "attributes": { "award_id": "1P01AI175399-01A1", "title": "Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6626, "first_name": "Nancy", "last_name": "Vazquez-Maldonado", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-04-10", "end_date": "2029-03-31", "award_amount": 3046145, "principal_investigator": { "id": 21143, "first_name": "Amal O", "last_name": "Amer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 26224, "first_name": "Jianrong", "last_name": "Li", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 31334, "first_name": "Estelle A", "last_name": "Cormet-Boyaka", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "OVERALL - ABSTRACT COVID-19 is a world-wide health problem caused by SARS-CoV-2 viral infection in the lung with long-term symptoms in at least one third of patients. Many COVID-19 patients suffer from silent or identified thrombi in major organs such as the lung and the brain and have increased occurrence of cardiac events. They also experience high levels of inflammatory cytokines collectively called cytokine storm. Combined, these reactions lead to organ damage and long- term sequelae of infection commonly termed Long-COVID. Our Program team will join forces to determine the host cell mechanisms underlying tissue damage in the lung and how SARS-CoV- 2 alters immune responses (Project 1), as well as in the brain and blood circulation (Project 2). Identification and targeting of host mechanisms that control the multi-organ inflammatory pathologies of COVID-19 will synergize with the targeting of cellular enzymes that control SARS- CoV-2 replication (Project 3). Together, our team will reveal and test novel therapeutic targets to collectively tame inflammation, neuroinflammation and thrombosis and to restrict viral replication. To achieve such a comprehensive overall goal, the three Projects by four Cores that will offer administration, biostatistical and bioinformatic support, animal models and purified viral strains, and relevant primary cell types with genetic manipulations to perform the planned experiments. Our Program will spearhead efforts to better understand the mechanisms of COVID-19 pathology in different organs and to identify novel drug targets to limit the severity of COVID-19 and the development of Long-COVID.", "keywords": [ "2019-nCoV", "Acute", "Affect", "Animal Model", "Anti-viral Agents", "Bioinformatics", "Biological", "Biological Markers", "Biometry", "Blood", "Blood - brain barrier anatomy", "Blood Circulation", "Blood Coagulation Disorders", "Blood specimen", "Brain", "Brain Pathology", "CASP4 gene", "COVID-19", "COVID-19 patient", "COVID-19 severity", "COVID-19 treatment", "Cardiac", "Cardiovascular system", "Caspase", "Cell Physiology", "Cells", "Cerebrum", "Complement", "Derivation procedure", "Development", "Disease", "Dose", "Endothelial Cells", "Enzymes", "Event", "Evolution", "Goals", "Health", "Heart", "Homologous Gene", "Human", "Immune", "Immune System Diseases", "Immune response", "Immunity", "Infection", "Inflammasome", "Inflammation", "Inflammatory", "Inflammatory Response", "Innate Immune Response", "Knock-out", "Knockout Mice", "Lead", "Long COVID", "Lung", "Maintenance", "Mediating", "Methods", "Methyltransferase", "Modeling", "Mus", "Nervous System Disorder", "Organ", "Outcome", "Pathogenicity", "Pathology", "Patients", "Population", "Production", "Pulmonary Pathology", "RNA", "Reaction", "Reagent", "Recording of previous events", "Reporting", "Respiratory Disease", "Role", "SARS-CoV-2 infection", "Severity of illness", "Symptoms", "Synaptic plasticity", "Syndrome", "Techniques", "Testing", "Therapeutic", "Thrombosis", "Thrombus", "Tissues", "Vaccines", "Variant", "Viral", "Viral Load result", "Virus Diseases", "Virus Replication", "Wild Type Mouse", "adaptive immune response", "brain circulation", "cell injury", "cell type", "cellular targeting", "collaborative approach", "cytokine", "cytokine release syndrome", "emerging virus", "experience", "experimental study", "genetic manipulation", "immunothrombosis", "insight", "long-term sequelae", "member", "myelination", "nanoparticle", "neuroinflammation", "new therapeutic target", "novel", "pathogen", "prevent", "programs", "response", "restraint", "small hairpin RNA", "synergism", "therapeutic target", "trafficking", "transcriptomics", "translational potential", "unvaccinated", "viral rebound", "viral resistance" ], "approved": true } }, { "type": "Grant", "id": "14641", "attributes": { "award_id": "1IK2RX004764-01A1", "title": "Cognitive rehabilitation to improve functioning in Veterans following COVID-19", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2024-04-01", "end_date": "2029-03-31", "award_amount": null, "principal_investigator": { "id": 31341, "first_name": "TARA", "last_name": "AUSTIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2485, "ror": "https://ror.org/00znqwq11", "name": "VA San Diego Healthcare System", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "2-8% of the US population report “long COVID” symptoms – including “brain fog,” thinking difficulties, memory problems, and psychiatric symptoms such as sleep disturbance, anxiety, and depression. Rates of post- COVID-19 symptoms are nearly double in the Veteran population. These cognitive symptoms contribute to functional impairments, reduced quality of life, poorer self-reported health status, psychological distress, delayed return to work, new onset disability, reduced community integration, and increased healthcare utilization. One promising treatment to improve both everyday functioning and cognition secondary to post- COVID-19 symptoms is Compensatory Cognitive Training (CCT). Previous studies have found that CCT is feasible, acceptable, and efficacious in Veteran populations with multiple sources of cognitive dysfunction. The proposed CDA provides a golden opportunity to evaluate CCT for Veterans with prolonged COVID-19 symptoms (CCT-C), compared with a robust control condition, Holistic Cognitive Education (HCE). The project closely aligns with current RR&D priorities, by “examining COVID-19-specific rehabilitation interventions and responses to treatment” and by addressing “late or delayed effects of secondary conditions related to COVID- 19 infections on impairment and disability.” Specific aims are 1) to conduct a pilot randomized controlled trial of remote CCT-C with 70 Veterans (35 CCT-C, 35 HCE) with post-COVID-19 cognitive symptoms to examine feasibility, acceptability, and initial efficacy; 2) to examine the preliminary efficacy of CCT-C in this population on overall functioning, as measured by the World Health Organization’s Disability Assessment Schedule (WHODAS 2.0), performance-based measures of functional capacity, and secondary outcomes (cognitive performance, quality of life, self-reported cognitive problems, psychiatric symptoms, sleep disturbance, and engagement in work/community activities); and 3) to explore moderators of outcome (e.g., age, initial COVID- 19 severity, baseline cognitive functioning, presence of PTSD/mTBI history; biomarkers related to COVID-19 infection). The candidate, Dr. Tara Austin, is currently a Postdoctoral Fellow at the VA San Diego Healthcare System. The overarching objective of Dr. Austin’s Career Development Award–2 (CDA-2) research plan is to build on her previous clinical and research experience in interventional neuropsychology and establish her research career focused on cognitive rehabilitation treatments for Veterans. Specifically, her training plan has been designed to develop expertise in adapting cognitive rehabilitation treatments for novel populations exposed to a range of chemical, physical, environmental, and infectious hazards, including exposure to novel infectious diseases, such as COVID-19. Her proposed training includes training in cognitive rehabilitation (Dr. Twamley), clinical trial methodology (Drs. Twamley and Thomas), cognitive and functional outcomes (Drs. Twamley, Ford, and Wynn), biomarkers associated with neuroinflammation (Drs. Ford and Pulliam), and advanced statistical techniques (Dr. Thomas). This training will support Dr. Austin’s career as an independent VA research scientist with expertise in developing and evaluating interventions to improve functioning and quality of life in Veterans with cognitive symptoms secondary to exposures or illnesses such as COVID-19.", "keywords": [ "Acceleration", "Activities of Daily Living", "Acute", "Address", "Adverse effects", "Age", "Anxiety", "Area", "Attention", "Biological Markers", "Brain", "COVID-19", "COVID-19 severity", "Cardiovascular system", "Chemicals", "Chronic Headaches", "Chronic Phase", "Classification", "Clinical", "Clinical Trials", "Cognition", "Cognitive", "Cognitive aging", "Communicable Diseases", "Communities", "Community Integration", "Contracts", "Development", "Diagnosis", "Diagnostic", "Disability Evaluation", "Disabling", "Disease", "Education", "Employment", "Exposure to", "Fatigue", "Feedback", "Functional impairment", "Health Status", "Health behavior", "Healthcare Systems", "Household", "Human", "Hypoxia", "Immune response", "Impaired cognition", "Impairment", "Infection", "Inflammatory", "Injury", "Intervention", "Interview", "K-Series Research Career Programs", "Length", "Long COVID", "Measures", "Mediating", "Memory", "Mental Depression", "Mentors", "Mentorship", "Methodology", "Moods", "Neurobehavioral Manifestations", "Neurons", "Neurophysiology - biologic function", "Neuropsychology", "Outcome", "Participant", "Patient Self-Report", "Persons", "Population", "Post-Traumatic Stress Disorders", "Postdoctoral Fellow", "Protocols documentation", "Psychometrics", "Quality of life", "Randomized Controlled Trials", "Recording of previous events", "Rehabilitation therapy", "Reporting", "Research", "Respiratory Signs and Symptoms", "Risk", "SARS-CoV-2 infection", "SARS-CoV-2 negative", "Sampling", "Schedule", "Scientist", "Secondary to", "Sleep disturbances", "Social Functioning", "Source", "Structure", "Symptoms", "Techniques", "Thinking", "Time", "Training", "Trauma", "Veterans", "Viral", "Work", "World Health Organization", "World Health Organization Disability Assessment Schedule", "active control", "acute COVID-19", "blood-brain barrier crossing", "brain fog", "career", "cerebrovascular", "chronic pain", "cognitive change", "cognitive function", "cognitive performance", "cognitive rehabilitation", "cognitive training", "cost", "design", "disability", "emotional functioning", "executive function", "experience", "functional improvement", "functional independence", "functional outcomes", "hazard", "health care service utilization", "improved", "longitudinal analysis", "mild traumatic brain injury", "military veteran", "neuroinflammation", "neuropsychiatric symptom", "nove" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1419, "count": 14184 } } }