Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=award_amount
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=award_amount", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=award_amount", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=award_amount", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=award_amount" }, "data": [ { "type": "Grant", "id": "6605", "attributes": { "award_id": "3U54EB015408-09S2", "title": "Point of Care Technology Research Center in Primary Care", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22147, "first_name": "Tiffani Bailey", "last_name": "Lash", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2012-07-01", "end_date": "2023-05-31", "award_amount": 3947568, "principal_investigator": { "id": 22148, "first_name": "John A", "last_name": "Parrish", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22149, "first_name": "Steven", "last_name": "Schachter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Overall The Point-of-Care Technology Research Center in Primary Care proposes to further develop a national “center-without-walls” for rapid transformation of emerging point-of-care technologies into commercially viable, clinically focused solutions for improving primary healthcare. The Center was established by the Consortia for Improving Medicine through Innovation and Technology (CIMIT), a consortium of research institutions, universities, military medicine centers and hospitals throughout the US with international affiliates at University of Manchester-UK (MIMIT), Barcelona (The Center for the Integration of Medicine and Innovative Technologies in Catalonia) and Singapore (A*-STAR/Eastern Health Alliance). CIMIT established the Point-of- Care Technology Research Center in Primary Care under a Cooperative Agreement (U54) award from National Institute of Biomedical Imaging and Bioengineering (NIBIB) in 2012 and the Center created a national network of research sites, harnessing the power of multidisciplinary collaboration to speed the translation of high-impact research into primary care practice and broader dissemination by commercially licensable opportunities. We will build upon our proven approach to needs-driven primary healthcare technology innovation to expand and significantly enhance our Center. The Center’s overall objective is to build upon the progress made under the previous U54 award and offer expanded support to teams through the integrated functional elements of the proposed enhanced Center. In so doing, the Center will offer a portfolio of synergistic support to teams with innovative solutions through defined interfaces and hand offs throughout the innovation process while continuously improving the Center’s processes of finding, funding, facilitating, and following projects. The long-term goal is to create a dynamic, sustainable national network that identifies key unmet needs in the delivery of primary care as well as promising emerging technologies and then to accelerate their translation into clinical applications for broad impact in primary care medicine through high-quality translational and clinical research.", "keywords": [ "Address", "Area", "Award", "Caring", "Chronic Disease", "Clinical", "Clinical Research", "Collaborations", "Elements", "Emerging Technologies", "Engineering", "Environment", "Funding", "Goals", "Hand", "Health", "Health Alliance", "Health Technology", "Healthcare", "Hospitals", "Institution", "Interdisciplinary Study", "International", "Laboratories", "Licensing", "Medicine", "Methodology", "Military Medicine", "Modeling", "National Institute of Biomedical Imaging and Bioengineering", "Outcome", "Patients", "Performance", "Point of Care Technology", "Primary Care Physician", "Primary Health Care", "Process", "Recommendation", "Research", "Resources", "Scientist", "Singapore", "Site", "Speed", "Students", "Technology", "Testing", "Training", "Translational Research", "Translations", "U-Series Cooperative Agreements", "Universities", "aging population", "care providers", "clinical application", "commercialization", "design", "experience", "follow-up", "improved", "industry partner", "innovation", "innovative technologies", "meetings", "point of care", "prototype" ], "approved": true } }, { "type": "Grant", "id": "15360", "attributes": { "award_id": "1UG3DA059278-01A1", "title": "Development of SBS-226, a MOR agonist / DOR antagonist, for OUD", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 31959, "first_name": "David A", "last_name": "White", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-30", "end_date": "2026-08-31", "award_amount": 3957359, "principal_investigator": { "id": 31960, "first_name": "Jeffrey", "last_name": "Reich", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2537, "ror": "", "name": "SPARIAN BIOSCIENCES, INC.", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Opioid use disorder (OUD) is a chronic disorder characterized by the repeated, compulsive use of opioid drugs with a detrimental impact to one’s physical, social, and psychological wellbeing. The use of prescription opiates is often necessary to control moderate to severe levels of pain. However, about 10% of patients prescribed an opiate for a medical condition are at risk for developing OUD. Opiate Use Disorder is a global problem but is at crisis levels in the U.S with significant mortality. It is estimated in this country that about ~11M misuse opioids, ~5.6M people have OUD and close to 80K died from opioid related overdoses. Sadly, the COVID epidemic has worsened the epidemic by increasing risk factors for OUD and occurred at a time when fentanyl has flooded the supply. Current treatments are primarily buprenorphine and methadone. Despite treatment options, OUD is difficult to effectively treat long-term due to access, stigma, and efficacy of the compounds. Mitragyna speciosa, a plant commonly known as kratom, has anecdotally been used for treatment of opiate withdrawal and OUD. The naturally occurring active substance is believed to be mitragynine and the 7- OH mitragynine (7OH) metabolite which act through the mu opioid receptor. An active metabolite of mitragynine, 7OH mitragynine, demonstrates MOR agonist properties such as analgesia, tolerance, physical dependence, and reinforcing effects. In contrast, an analog of mitragynine named 9-methoxy corynantheidine pseudoindoxyl (9CP) has a very different receptor binding profile and in vivo properties. 9CP is an partial agonist at MOR and it is also a delta opioid receptor (DOR) antagonist. Unlike the natural products found in kratom, when studied in mice under acute dosing 9CP is non-addictive, and demonstrates far less respiratory depression, tolerance, and signs of physical dependence than morphine. Most importantly, in mice, 9CP can ameliorate naloxone-precipitated withdrawal in morphine-dependent mice. Sparian has created a series of 9CP analogs and screened them across CMC, ADME, and PK properties and identified a lead candidate – SBS-226. Therefore, as an innovative pharmacological approach, we propose the development of SBS-226 as a novel selective, potent and non-addictive chemical entity utilizing mixed MOR agonism/DOR antagonism for the treatment of OUD. In the present application, we propose a full IND-enabling development plan and Phase 1 clinical trial.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12121", "attributes": { "award_id": "1UC7AI180307-01", "title": "Resources, Workforce Development, and Animal Models for the Rutgers RBL", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 27982, "first_name": "FAYNA C", "last_name": "Diaz San Segundo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-08-18", "end_date": "2028-07-31", "award_amount": 3970689, "principal_investigator": { "id": 8100, "first_name": "David", "last_name": "Alland", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 925, "ror": "", "name": "RBHS-NEW JERSEY MEDICAL SCHOOL", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1856, "ror": "", "name": "RUTGERS BIOMEDICAL AND HEALTH SCIENCES", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "Overall ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) therapeutic, pathogenesis, and diagnostic research on high threat biological agents with a focus on Mycobacterium tuberculosis and SARS-CoV-2, as well as other category A, B, and C pathogens. The RBL serves academic and commercial entities within Rutgers University, the Northeast United States and nationally, while also engaging globally with companies and academic institutions through collaborations and research contracts. This proposal will provide support that enhances the RBL’s ability to fulfill its research and biothreat response/pandemic preparedness missions while also supporting an expanding faculty/staff. We propose to accomplish these goals by improving the RBL facilities, support services, BSL3 practice development and implementation and special services offerings though the execution of three aims: Aim 1. Establish a Facility management, maintenance and operations (FMMO) core. Aim 2. Establish a BSL-3 Practices core (Practice core). Aim 3. Establish a biocontainment research support service core devoted to developing animal models of BSL3 pathogens and associated support services (Animal models and related services, or AMRS core). The FMMO core will provide BSL3 and ABSL3 services, management and oversight, for routine animal husbandry, microbiology and virology services in support of investigators grant funded research projects while ensuring efficient operations and maintenance of the BSL3 facilities and providing trained staff to support the BSL3 building systems and equipment. The Practice core will develop and maintain standard operating procedures and training for research in the RBL BSL3 laboratories including best practices, emergency response, waste management, shipping, husbandry, select agent-specific practices and inventory. It will also develop and conduct biosecurity and disaster drills and liaise with other BSL3 laboratories within the RBL network as well as local, state and federal health agencies to coordinate operations and plan for joint responses to new infectious disease threats. The AMRS core will develop critical animal models including those of SARS-CoV2 and highly pathogenic influenza virus transmission, COVID-19 PASC, pulmonary impairment after TB (PIAT), and drug treatment models, and then support grant funded investigators in the performance of these models along with the advanced instrumentation needed to analyze these infected models and their tissues/cells in a BSL3 environment. Together, these three cores will significantly enhance the near- and long-term abilities of the RBL to address critical biothreats and emerging infectious diseases requiring study in a BSL3 laboratory setting, while also increasing our capacity to respond to the next public health emergency or pandemic.", "keywords": [ "2019-nCoV", "Address", "Aftercare", "Animal Husbandry", "Animal Model", "Animals", "Bacillus anthracis", "Biological Products", "Budgets", "COVID-19", "Candida auris", "Categories", "Cells", "Certification", "Chikungunya virus", "Collaborations", "Communicable Diseases", "Computers and Advanced Instrumentation", "Containment", "Cryptococcus", "Development", "Diagnostic", "Diagnostics Research", "Disasters", "Disease model", "Emergency response", "Emerging Communicable Diseases", "Ensure", "Environment", "Equipment", "Equipment and supply inventories", "Faculty", "Francisella tularensis", "Funding", "Goals", "Grant", "HIV", "Health", "Impairment", "Institution", "Joints", "Laboratories", "Laboratory Research", "Life Cycle Stages", "Lung", "Maintenance", "Microbiology", "Mission", "Modeling", "Monkeypox", "Mycobacterium tuberculosis", "Pathogenesis", "Pathogenicity", "Performance", "Pharmacotherapy", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Procedures", "Research", "Research Activity", "Research Contracts", "Research Personnel", "Research Project Grants", "Research Support", "Research Training", "Resources", "Safety", "Scientist", "Services", "Shipping", "System", "Therapeutic", "Tissues", "Training", "Tuberculosis", "United States", "United States National Institutes of Health", "Universities", "Viral", "Virulent", "Waste Management", "Work", "Workforce Development", "Yersinia pestis", "biosecurity", "biothreat", "cost", "end of life", "improved", "influenzavirus", "laboratory facility", "operation", "pandemic disease", "pandemic preparedness", "pathogen", "public health emergency", "recruit", "response", "tuberculosis drugs", "tuberculosis treatment", "viral transmission", "virology" ], "approved": true } }, { "type": "Grant", "id": "9155", "attributes": { "award_id": "75N92020C00021-P00001-9999-1", "title": "RADX TECH - CERES NANOSCIENCE INC NANOTRAP PARTICLE MANUFACTURING", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Biomedical Imaging and Bioengineering (NIBIB)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2020-08-28", "end_date": "2021-05-31", "award_amount": 3974000, "principal_investigator": { "id": 24014, "first_name": "ROSS", "last_name": "DUNLAP", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1155, "ror": "", "name": "CERES NANOSCIENCES, LLLP", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1155, "ror": "", "name": "CERES NANOSCIENCES, LLLP", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true }, "abstract": "Ceres Nanosciences, developer of Nanotrap particles for extracting and concentrating SARS-CoV-2, have successfully validated the use of these particles in multiple laboratories and contexts to capture and concentrate SARS-CoV-2 from biological solutions or wastewater at levels currently below the limit of detection of existing methods. This has attracted the interest of over 15 commercial partners, such as LabCorp, who are leading the national efforts to provide diagnostic tests for COVID-19 infection. The cumulative needs for these partners are tests in excess of 2,000,000/day. Our current manufacturing processes are not able to meet this demand and represent a bottleneck to helping to address the national crisis. As such, Ceres Nanosciences is requesting RADx support to rapidly scale-up Nanotrap manufacturing and distribution under our existing quality management system to meet the demand of partners, such as LabCorp, who are poised to leverage the technology for point-of-care and confirmatory testing for COVID-19 infection. EUA amendment data collection and supply contract agreements are in process.", "keywords": [ "2019-nCoV", "Address", "Agreement", "Amendment", "Biological", "COVID-19 testing", "Contracts", "Data Collection", "Diagnostic tests", "Laboratories", "Methods", "Point of Care Technology", "Process", "RADx", "RADx Tech", "SARS-CoV-2 infection", "System", "Testing", "detection limit", "interest", "manufacturing process", "nanoscience", "particle", "scale up" ], "approved": true } }, { "type": "Grant", "id": "2404", "attributes": { "award_id": "3OT2HL161847-01S1", "title": "OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 6733, "first_name": "Michelle", "last_name": "Olive", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-05-24", "end_date": "2023-05-23", "award_amount": 3976568, "principal_investigator": { "id": 6734, "first_name": "Rachel Sharon", "last_name": "Gross", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 6736, "first_name": "Leora", "last_name": "Horwitz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 6738, "first_name": "STUART D", "last_name": "KATZ", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 6739, "first_name": "Andrea B", "last_name": "Troxel", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": null, "keywords": [], "approved": true } }, { "type": "Grant", "id": "10205", "attributes": { "award_id": "2121410", "title": "RII Track-2 FEC: Genome Engineering to Sustain Crop Improvement (GETSCI)", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Office Of The Director", "EPSCoR Research Infrastructure" ], "program_reference_codes": [], "program_officials": [ { "id": 11391, "first_name": "J.D.", "last_name": "Swanson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-10-01", "end_date": "2025-09-30", "award_amount": 3993756, "principal_investigator": { "id": 26160, "first_name": "Michael", "last_name": "Muszynski", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26156, "first_name": "Jianming", "last_name": "Yu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26157, "first_name": "Zhi-Yan", "last_name": "Du", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26158, "first_name": "Teresita D", "last_name": "Amore", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 26159, "first_name": "Keunsub", "last_name": "Lee", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 684, "ror": "", "name": "University of Hawaii", "address": "", "city": "", "state": "HI", "zip": "", "country": "United States", "approved": true }, "abstract": "Improved and practical crop breeding tools are required to meet the increasing demands of a growing global population and to overcome the sudden and variable stresses, made worse, by climate change. This project brings together researchers from the University of Hawai’i at Manoa and Iowa State University to develop an efficient, robust genome engineering toolkit that can be used to speed the generation of resilient crops adapted to a changing environment. Reproductive barriers are a major bottleneck that limits the genetic diversity available for crop improvement. Tropical maize germplasm is a rich source of genetic diversity but its flowering behavior in temperate regions precludes its broad use for maize improvement. To access this diversity, our two institutions formed a collaboration that integrates our strengths in tropical plant biology and transformation (Hawai’i) with maize transformation, genome engineering, and breeding (Iowa). Our goals are to establish a rapid and efficient genetic transformation platform and to develop improved genome editing tools to reprogram the flowering behavior of high-yielding tropical maize lines allowing their incorporation into any maize breeding program. Both Hawai’i and Iowa will gain a valuable new capability in genetic transformation and genome engineering which will transform the types of crop research possible at both institutions. Expected impacts from this project will help address food security and economic weaknesses in Hawai’i, by allowing for the development of new tropical crop breeding industries. In Iowa, access to gene-edited temperate-adapted tropical germplasm will move maize improvement into the next era of genome-optimized breeding. Workforce capacity will be increased by engaging underrepresented students, particularly Native Hawai’ians and Pacific Islanders, in diverse aspects of genome engineering research, by the exchange of undergraduates between partner institutions to prepare a globally competitive, multiculturally, and socially responsible workforce, and by creating opportunities for improved science communication skills through training sessions, workshops, and engagement with the community to communicate the value and safety of these new tools. \n\nCritical to our future is maintaining the rate of genetic improvement of the crops that feed us and sustain our economy. But the sudden and increasingly severe stresses caused by climate change limit the pace of improvement. Advances in genome engineering offer rapid solutions by enabling precise and targeted reprogramming of molecular networks to improve crop performance. The rich genetic diversity in tropical maize is largely underutilized for maize improvement because tropical lines are photoperiod sensitive and flower late in the long-days of temperate growing regions. To access this diversity, we formed a collaboration between the University of Hawai’i at Manoa (UH Manoa) and Iowa State University (ISU), which integrates strengths in tropical plant system biology and transformation (UH Manoa) with maize transformation, genome engineering, and breeding (ISU). Our goal is to use gene editing to suppress the photoperiod response in elite, high-yielding tropical maize to promote earlier flowering. These edited tropical lines can then be used to enhance any maize breeding program. Our objectives are to (1) establish an efficient, germplasm-independent maize transformation platform, (2) develop a facile, tractable genome editing toolkit to suppress the photoperiod response in six tropical inbreds, (3) analyze photoperiod network function in genome edited tropical lines, and (4) improve skills in communicating the value and safety of these new genome engineering tools. \nThe outcomes from this project include new tropical maize transformation capabilities at both jurisdictions, genome editing reagents for modulating flowering in maize, six elite tropical inbreds adapted to temperate breeding programs, a mechanistic understanding of the response to reprogramming the flowering network, and improved skills to communicate the value of this technology in professional and public contexts. Broader impacts expected from this project include opening this technology to academic labs, that can build research capacity by allowing genome engineering of diverse crops. Democratizing these tools are expected to speed breeding advancements, sustain crop improvement efforts, and spur economic growth. Both Hawai’i and Iowa will gain a valuable new capability in maize transformation and genome engineering, and will transform the types of crop research possible at both institutions. In Hawai’i, this project will help address food security and economic weaknesses revealed by the pandemic, by allowing for development of new tropical crop breeding industries. In Iowa, access to gene-edited temperate-adapted tropical germplasm moves maize improvement into the next era of genome-optimized breeding. Workforce capacity will be increased by engaging underrepresented students, particularly Native Hawai’ians and Pacific Islanders, in diverse aspects of genome engineering research, by the exchange of undergraduates between partner institutions to prepare a globally competitive, multiculturally, and socially responsible workforce, and by creating opportunities for improved science communication skills through training sessions, workshops, and engagement with the community to communicate the value and safety of these new tools.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10588", "attributes": { "award_id": "1G20AI174723-01", "title": "BSL3 Enhancements for RNA Virus Pandemic Preparedness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 24445, "first_name": "Nancy G.", "last_name": "Boyd", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-16", "end_date": "2024-02-29", "award_amount": 3994219, "principal_investigator": { "id": 26614, "first_name": "Hardy", "last_name": "Kornfeld", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 790, "ror": "", "name": "UNIV OF MASSACHUSETTS MED SCH WORCESTER", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Program Summary/Abstract The University of Massachusetts Chan Medical School (UMass Chan) seeks NIH G20 funding to repair, renovate, and modernize the existing Biosafety Level 3 (BSL3) and Animal BSL3 (ABSL3) facilities to enhance current research on RNA viruses of pandemic potential. As an internationally recognized leader in infectious disease research, UMass Chan has made pivotal contributions to this field, including work on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), highly pathogenic avian influenza virus, Newcastle disease virus, and Zika virus. At the start of the coronavirus 2019 (COVID-19) pandemic, we quickly became one of the leading institutes for research and clinical trials on SARS-CoV-2. Our researchers obtained several awards from the NIH, NSF, and Department of Defense, as well as private foundations for these studies. As a leading site for COVID-19 clinical trials, UMass Chan is uniquely poised to bridge clinical and basic research studies on these RNA viruses by enabling essential research on patient samples to complement in vitro and in vivo studies. Our findings can be translated to develop novel prevention and therapeutic strategies leveraging our world-renowned RNA Therapeutics Institute, our Institute for Drug Resistance, and our partnership with MassBiologics for vaccine development, making UMass Chan a powerhouse for bench-to-bedside translational research. The UMass Chan BSL3 Core Laboratories have seen a staggering increase in usage due to the pandemic. Our BSL3 and ABSL3 facilities need major updates and renovations to keep pace with our research programs and continue to provide a safe, modern, and efficient lab for BSL3 work. The last time these facilities were completely renovated was over a decade ago (2003–2005 for our ABLS3 and 2010–2014 for our BSL3). We will modernize the existing BSL3 and ABSL3 facilities by updating the ceiling and ventilation systems, installing new autoclaves, maximizing the existing footprint by removing outdated equipment, and updating cameras for safety. These updates will significantly enhance research on RNA viruses of pandemic potential by addressing deficiencies that have caused prolonged downtime for repairs, and by enhancing the resilience of critical building systems. Our UMass Chan Facilities and Campus Services team has extensive experience executing design, renovations, and oversight of the operations and have worked with the NIH on previous G20 and C06- funded improvements to our facilities. The G20 funding will also be backed by strong institutional support for this project and a commitment to fully equip the updated space with state-of-the-art scientific instruments and other equipment needed to maintain the productivity of currently funded and future research on SARS-CoV-2 and other BSL3-level RNA viral pathogens. With G20 funding, our BSL3 and ABSL3 labs can get much- needed updates to support our faculty as they continue to make ground-breaking fundamental discoveries with translational potential to address SARS-CoV-2 and other RNA viruses of pandemic potential.", "keywords": [ "2019-nCoV", "Address", "Air", "Alphavirus", "Ambulatory Care", "Animals", "Avian Influenza A Virus", "Award", "Back", "Basic Science", "Biotechnology", "COVID-19", "COVID-19 pandemic", "Carbon Dioxide", "Chikungunya virus", "Clinical Research", "Clinical Trials", "Communicable Diseases", "Communication", "Complement", "Coronavirus", "Department of Defense", "Drug resistance", "Ensure", "Equipment", "FDA approved", "Faculty", "Foundations", "Freezing", "Funding", "Goals", "Hamsters", "Hantavirus", "Housing", "Immune", "Immunoglobulin A", "In Vitro", "Incubators", "Infectious Diseases Research", "Innovative Therapy", "Institutes", "Institution", "Integration Host Factors", "International", "Laboratories", "Manuscripts", "Massachusetts", "Modernization", "Nature", "Newcastle disease virus", "Pathogenicity", "Patients", "Positioning Attribute", "Prevention", "Prevention strategy", "Privatization", "Procedures", "Productivity", "Protocols documentation", "RNA", "RNA Viruses", "RNA vaccine", "Research", "Research Institute", "Research Personnel", "Research Project Grants", "Resources", "SARS coronavirus", "SARS-CoV-2 pathogenesis", "Safety", "Sampling", "Security", "Services", "Site", "Structure", "System", "Therapeutic", "Time", "Translating", "Translational Research", "United States National Institutes of Health", "Universities", "Update", "Virus Diseases", "Virus-like particle", "Work", "Zika Virus", "base", "bench to bedside", "biosafety level 3 facility", "cost", "design", "experience", "hemorrhagic fever virus", "humanized mouse", "in vivo", "innovation", "instrument", "medical schools", "member", "mouse model", "novel", "operation", "pandemic disease", "pandemic preparedness", "pathogen", "pathogenic bacteria", "pathogenic virus", "programs", "recruit", "repaired", "research study", "resilience", "square foot", "therapeutic RNA", "translational potential", "translational study", "treatment strategy", "vaccine development", "vaccine strategy", "ventilation" ], "approved": true } }, { "type": "Grant", "id": "8103", "attributes": { "award_id": "75N93021C00012-0-9999-3", "title": "Statistical and Data Coordinating Center: SARS-CoV-2/COVID-19 Studies", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-03-01", "end_date": "2022-02-28", "award_amount": 3994239, "principal_investigator": { "id": 23982, "first_name": "MARIAN", "last_name": "EWELL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1673, "ror": "", "name": "THE EMMES COMPANY, LLC", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1673, "ror": "", "name": "THE EMMES COMPANY, LLC", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The goal of the Statistical and Data Coordinating Center is to provide comprehensive statistical support, data management and analysis activities for DMID-sponsored COVID clinical research trials. This includes internet-based electronic data collection, data management, data quality control and a specimen tracking system. In addition, the contractor provides consultation on statistics, study design, appropriate control groups, sample size, power calculations, randomization, stratification, and analysis.", "keywords": [ "2019-nCoV", "COVID-19", "Clinical Research", "Clinical Trials", "Consultations", "Contractor", "Control Groups", "Data Analyses", "Data Collection", "Data Coordinating Center", "Goals", "Internet", "Quality Control", "Randomized", "Research Design", "Sample Size", "Specimen", "Stratification", "System", "base", "coronavirus disease", "data management", "data quality", "electronic data", "research study", "statistics" ], "approved": true } }, { "type": "Grant", "id": "12398", "attributes": { "award_id": "1C06OD035570-01", "title": "Expansion of Macaque Breeding runs at the New Iberia Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-12", "end_date": "2027-08-31", "award_amount": 3999070, "principal_investigator": { "id": 24751, "first_name": "Francois J", "last_name": "Villinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 2094, "ror": "", "name": "RAGIN' CAJUN FACILITIES, INC.", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "University of Louisiana at Lafayette C06 Expansion of Macaque Breeding capacity at the New Iberia Research Center Abstract: As part of its expansion of its HIV/AIDS research program, the New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette (UL Lafayette) proposes to add macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation for an added capacity of 1600 macaque breeders + offsprings via the Ragin Cajun Facilities, Inc. Foundation. NIRC has experienced exponential growth in the past 6 years, playing a critical role in the SARS-CoV2 pandemic while maintaining a vigorous HIV research program in support of collaborators whose laboratories were shut down. As part of this growth, NIRC has expanded its nonhuman primate (NHP) breeding and cohorts, from 6,400 to >10,000 NHPs, now the largest primate center in the US. The recent suspension of primate export from China and the limitations on NHP transport in cargo, have created an acute and monumental shortage of research NHPs, markedly amplified by their heavy use to test COVID vaccines and therapies. This has doubled and tripled animal acquisition costs, which will largely limit primate based research for academic investigators for the next decade and beyond. In efforts to palliate this gap in supply, NIRC has, and continues to expand NHP breeding and research housing, in addition to ongoing renovation of laboratory space and the construction of a BSL-3 facility regrouping rodents, NHPs and labs. The ongoing increase in breeder and research space has been the conversion of space originally used for chimpanzees into monkey social and research (quad cages) housing, and the construction of 2 new multi-run housing buildings supported by a C06 award obtained in 2021 (projected completion and occupancy date in late 2023). NIRC currently has ~1400 2-4 year old rhesus macaques future breeders slated to occupy this space, and given an annual live birth rate of >1000 rhesus macaques, NIRC has to expand such housing option further, via the construction of 2 additional identical units via this proposal. Of note, there will be space for 3 more such units for future expansion in the same area. This type of building has been specifically designed and extensively tested for macaque housing/breeding at a facility in Texas, attesting to the adequacy, ease of maintenance and longevity of such construction in southern climates. Each building unit will comprise 20 indoor/outdoor runs able to accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. Many of these programs are experiencing delays due to NHP and space shortages, which are holding back the scientific expansion of NIRC and the support of HIV/AIDS NIH funded research.", "keywords": [ "4 year old", "Acute", "Air", "Animals", "Area", "Award", "Back", "Birth Rate", "Breeding", "COVID test", "COVID-19 pandemic", "China", "Circulation", "Climate", "Colorectal", "Electricity", "Foundations", "Funding", "Future", "Grouping", "Growth", "HIV", "HIV/AIDS", "Heating", "Housing", "Laboratories", "Live Birth", "Longevity", "Louisiana", "Macaca", "Macaca mulatta", "Maintenance", "Monkeys", "Mucous Membrane", "National Institute of Allergy and Infectious Disease", "Pan Genus", "Pathogenesis", "Play", "Primates", "Research", "Research Personnel", "Rodent", "Role", "Running", "Signal Transduction", "Site", "Suspensions", "Testing", "Texas", "Therapeutic", "United States National Institutes of Health", "Universities", "Vaccines", "Vagina", "Viral", "Water", "biosafety level 3 facility", "cohort", "cost", "design", "experience", "imaging capabilities", "microbicide", "nonhuman primate", "offspring", "palliate", "prevent", "programs", "social" ], "approved": true } }, { "type": "Grant", "id": "3549", "attributes": { "award_id": "1849430", "title": "Engineering for US All - E4USA: A National Pilot High School Engineering Course and Database", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Engineering (ENG)", "RES EXP FOR TEACHERS(RET)-SITE" ], "program_reference_codes": [], "program_officials": [ { "id": 11497, "first_name": "Amelia", "last_name": "Greer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-10-01", "end_date": "2022-09-30", "award_amount": 3999410, "principal_investigator": { "id": 11502, "first_name": "Darryll", "last_name": "Pines", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 297, "ror": "https://ror.org/047s2c258", "name": "University of Maryland, College Park", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 11498, "first_name": "Craig J", "last_name": "Scott", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 11499, "first_name": "Stacy S", "last_name": "Klein-Gardner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 11500, "first_name": "Kenneth J", "last_name": "Reid", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 11501, "first_name": "Adam R", "last_name": "Carberry", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 297, "ror": "https://ror.org/047s2c258", "name": "University of Maryland, College Park", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The College Board currently serves 7 million students, 23,000 high schools, and 3,600 colleges through the AP and SAT annually. However, no standardized educational program exists for pre-college students to earn widely accepted, transferable, engineering course credits. In addition, there are no nationally offered professional development programs to train and certify highly qualified, secondary teachers to support an undergraduate-level engineering course at the pre-college level. An Engineering for US All (E4USA), one-year high school course has the potential to 'democratize' the learning and practice of engineering by engaging high school students and their teachers to think and practice engineering principles and design practices, like an engineer. E4USA would be equivalent to placement credit for an introductory college course, such as: 1) core engineering; or 2) an elective; or 3) a substitute required course in the general education sequence. The impact might well go beyond an E4USA credit, through the credentialing of a broad range of STEM trained teachers to instruct and assess engineering principles and design-based experiences, and therefore become cornerstones supporting the introduction of engineering principles and design as outlined in the Next Generation Science Standards (NGSS). The E4USA framework will focus on three \"big ideas:\" 1) Engineering and Society; 2) Engineering Processes; and 3) Essential Engineering Content, Skills and Tools. Credit would be earned by students through two integrated pathways: 1) a standard's based curriculum covering the Principles of Engineering; and 2) a submission of a design project. The national pilot will be lead by the University of Maryland College Park and include Arizona State University, Morgan State University, Vanderbilt University, Virginia Tech, a dissemination collaboration with NASA, and a sampling of some 70 high schools across the United States.\n\nEngineering for US All (E4USA) would help to 'demystify' and 'democratize' engineering, and empower science, technology, engineering, and mathematics (STEM) teachers to gain the self-efficacy, self-confidence and skills to teach and assess their students engineering-based competencies. No standardized programs currently exist at a national level to train and certify high school teachers to support a one-year high school course based on engineering principles and a design-based experience. Our proposed national pilot would enable the standardized and centralization of data collection from across the United States, thus tracking STEM teachers and their students' trajectories of learning engineering concepts through competency-based evaluations and design project submissions. A national, data repository will be created and updated at the University of Maryland to track the training of the teachers, and their students. The research will explore if: 1) a broader diversity of students will consider engineering as an academic and career option; 2) professional development (PD) can enable teachers to apply engineering concepts across STEM disciplines to train students to tackle and solve problems; and 3) the piloting of the PD models can be used to certify highly qualified teachers. Projected outcomes will include: 1) a hybrid (e.g., in-person and online) PD model that prepares STEM teachers to gain the confidence, instructional skills and assessment competencies to support E4USA; 2) guidelines for the use of a Learning Management Systems and on-line analytical tools to collect data from a diverse sampling of teachers, students, institutions, and high schools; 3) E4USA course materials and resources; and 4) E4USA models that can be aligned to state and local high school graduation requirements.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1424, "count": 14236 } } }