Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=-start_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-start_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=-start_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-start_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=-start_date" }, "data": [ { "type": "Grant", "id": "7505", "attributes": { "award_id": "3U41HG003751-13S1", "title": "Rapid and Precise Molecular Pathway Modelling of the SARS-CoV-1 and SARS-CoV-2 Infection Cycle with Human Host Protein and Therapeutic Interactions", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 23309, "first_name": "Ajay", "last_name": "Pillai", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2007-04-01", "end_date": "2022-02-28", "award_amount": 310292, "principal_investigator": { "id": 23310, "first_name": "PETER G", "last_name": "DEUSTACHIO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1589, "ror": "https://ror.org/043q8yx54", "name": "Ontario Institute for Cancer Research", "address": "", "city": "", "state": "ON", "zip": "", "country": "CANADA", "approved": true } ] }, "other_investigators": [ { "id": 23311, "first_name": "Henning", "last_name": "Hermjakob", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23312, "first_name": "LINCOLN D.", "last_name": "STEIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23313, "first_name": "Guanming", "last_name": "Wu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1589, "ror": "https://ror.org/043q8yx54", "name": "Ontario Institute for Cancer Research", "address": "", "city": "", "state": "ON", "zip": "", "country": "CANADA", "approved": true }, "abstract": "The Reactome Knowledgebase is a widely used and internationally recognized expert-curated, open-source resource of a broad array of human biological processes and their disease counterparts, coupled to powerful tools for data analysis and display, and integrated with diverse community genomics resources. The work proposed here will add molecular annotations of the COVID-19 infection process mediated by the SARS-CoV-2 coronavirus, interactions between viral components and human host proteins that mediate the severity of viral infection, and the effects of therapeutics and drug-like compounds on both viral and host proteins. The resulting SARS-CoV-2 pathway annotations will provide a framework for pathway- and network-based data analysis and visualization, which will be critical for the interpretation of numerous COVID-19 studies now and in the future. In collaboration with a team of community experts in virology, drug design, and infectious disease, we will assemble information in two stages. First, a draft annotation will associate relevant SARS-CoV-1 and SARS-CoV- 2 viral and host cell proteins with each stage of the infection process and the host response to it. These annotations will be immediately useful for identifying additional relevant interacting proteins, for assessing possible effects of variation in the host or viral proteins on specific steps of viral infection, and for identifying possible drug targets. In the second stage, the SARS-CoV-2 map will be annotated more extensively to fill in molecular details of each step in these processes and to highlight differences in the processes mediated by SARS- CoV-2 virus and related coronaviruses. This annotation process will continue for the duration of the project to incorporate newly validated molecular details as they are uncovered by the research community. All the data, code and tools developed by this project will be open source and open.", "keywords": [ "2019-nCoV", "Authorship", "Biological Process", "COVID-19", "Cells", "Code", "Collaborations", "Communicable Diseases", "Communities", "Computer software", "Consensus", "Coronavirus", "Coupled", "Data", "Data Analyses", "Data Display", "Data Set", "Disease", "Disease Pathway", "Drug Design", "Drug Targeting", "Ensure", "Future", "Genomics", "Human", "Immune response", "Infection", "Innate Immune Response", "Institutes", "International", "Link", "Literature", "Manuals", "Maps", "Mediating", "Mining", "Modeling", "Molecular", "Natural Immunity", "Natural Language Processing", "Network-based", "Paper", "Pathogenicity", "Pathway interactions", "Peer Review", "Pharmaceutical Preparations", "Process", "Proteins", "Proteome", "Publishing", "Reaction", "Research", "Resources", "SARS coronavirus", "Severities", "Source", "System", "Systems Biology", "Therapeutic", "Therapeutic Effect", "Therapeutic Monoclonal Antibodies", "Variant", "Viral", "Viral Proteins", "Virus", "Virus Diseases", "Work", "adaptive immunity", "data integration", "data structure", "data tools", "data visualization", "experimental analysis", "knowledge base", "open source", "protein expression", "small molecule", "structured data", "tool", "virology" ], "approved": true } }, { "type": "Grant", "id": "5359", "attributes": { "award_id": "0642025", "title": "Conference: Twenty-Fourth Fungal Genetics Conference to be held in Pacific Grove, California from March 20 -25, 2007.", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "EUKARYOTIC GENETICS" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-03-15", "end_date": "2008-02-29", "award_amount": 4000, "principal_investigator": { "id": 18802, "first_name": "Marc", "last_name": "Orbach", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 438, "ror": "https://ror.org/03m2x1q45", "name": "University of Arizona", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 438, "ror": "https://ror.org/03m2x1q45", "name": "University of Arizona", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "The Twenty Fourth Fungal Genetics Conference will be held at the Asilomar Conference Center from March 20-25, 2007. Approximately 750-800 scientists and students from around the world will attend. The conference focuses on the molecular biology, genetics, genomics, biochemistry and cell biology of filamentous fungi.\n\nThis biennial conference promotes interaction between researchers interested in plant pathogens, medical pathogens, saprophytic fungi, and symbiotic fungi. All participants stay on the conference grounds, a fact that facilitates informal discussions among them and in the past has led to the development of new collaborations and research directions. The formal meeting will consist of four plenary sessions, four sets of concurrent sessions devoted to specialized areas, and three poster sessions. Topics to be covered in the plenary sessions include the following: 1) Genome structures and dynamics, 2) Host-pathogen and symbiotic interactions, 3) Development and metabolism, and 4) Sex, time, and evolution. Topics for the concurrent sessions will cover the following areas: 1)Whole genome comparative analysis, 2) Fungal-plant interactions, 3) Zygomycete and Chytrid genomics, biotechnology and evolutionary biology, 4)Teaching fungal biology and genetics, 5) Evolutionary genetics and genomics, 6) Associations between fungi and humans, 7)Regulation of primary and secondary metabolism, 8) Epigenetics and genome dynamics, 9) Population genetics, 10) Biological applications of genomic sequence data, 11) Biofilms, quorum sensing, and thigmotropism, 12) Dimorphic transitions, 13) Symbiotic and parasitic (viruses, nematodes, other fungi and insects) interactions, 14) Mating and sexual development, 15) RNA functions, 16) Circadian rhythms and photobiology, 17) Industrial mycology in the post-genomics era, 18) Proteome and postgenomic approaches to protein secretion, 19) Small molecules and signaling, 20) Apoptosis and vegetative incompatibility, 21) Evolution of gene clusters, 22) Cellular morphogenesis and development, 23) Signal transduction and cell surface receptors, 24) Cool tools for fungal biology: gene disruption and imaging, and 25) Advances in oomycete research and Basidiomycete biology.\n\nBeginning in the 1940s with the work of Beadle and Tatum, who first demonstrated the relationship between genetics and biochemistry, fungi have served as model eukaryotes, aiding in understanding of basic biological processes. This meeting places a strong emphasis on the participation of young scientists and students, particularly those from underrepresented groups. It provides many with their first opportunity to attend a major international conference and present their research findings, an important part of their training and professional development. Funds will be distributed on the basis of need and will be used to defray the travel and participation expenses of students, postdoctoral researchers, and some young scientists who would otherwise be unable to attend the meeting.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5364", "attributes": { "award_id": "0725489", "title": "Workshop-Physiological Research, Integration, Synthesis, and Modeling Center, to be held in Santa Barbara, CA, March 17 - 19, 2007.", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "Physiolgcl Mechnsms&Biomechnsm" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-03-15", "end_date": "2008-02-29", "award_amount": 15000, "principal_investigator": { "id": 18811, "first_name": "Martin", "last_name": "Frank", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1401, "ror": "https://ror.org/01y68k842", "name": "American Physiological Society", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18808, "first_name": "Hannah V", "last_name": "Carey", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18809, "first_name": "Terrie M", "last_name": "Williams", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 18810, "first_name": "James W", "last_name": "Hicks", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1401, "ror": "https://ror.org/01y68k842", "name": "American Physiological Society", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "This small grant will support a workshop to evaluate and initiate a National Center Network focusing on a Physiological Research, Integration, Synthesis and Modeling (PRISM) program. The concept will be explored during a two-day workshop on March 17-19, 2007 at the National Center for Ecological Analysis and Synthesis (NCEAS) facility (Santa Barbara, CA). \n\n \n\nThe specific aims of this workshop are to develop a document that \n\n1) refines the key elements of the NCN-PRISM program to reflect the broad interests of the organismal biological community, \n\n2) identifies current and potential partners for this endeavor, and \n\n3) outlines a development scheme for supporting the program. \n\n \n\nFifteen scientists representing the areas of physiological research, conservation, biomedicine, and zoological park communities have been identified to participate in this initial workshop. Each has expressed an interest in the development of an integrated program for comparative and ecological physiology. Through a series of presentations, discussions and writing assignments this group will evaluate the need, logistics and costs of creating a national center network for integrative physiology. The NCEAS was selected as the location for the workshop to encourage discussions with its director concerning the successful steps towards developing a national synthesis center (using NCEAS as an example) and the potential for future collaboration with the proposed PRISM Center.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5352", "attributes": { "award_id": "0710685", "title": "2007 Electrochemistry GRC - GOALI: Gordon Research Conference Activities to Stimulate University-Industry-Government Laboratory Partnerships and Increase Diversity in Science", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "OFFICE OF MULTIDISCIPLINARY AC" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-01-15", "end_date": "2007-12-31", "award_amount": 20000, "principal_investigator": { "id": 18780, "first_name": "Carol", "last_name": "Korzeniewski", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 18779, "first_name": "Peter T", "last_name": "Kissinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 226, "ror": "https://ror.org/05rad4t93", "name": "Gordon Research Conferences", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "This GOALI award enables participation by a significant number of female and underrepresented minority scientists in the 2007 Gordon Research Conference (GRC) on Electrochemistry that will be held in Ventura, CA, January 14 - 19, 2007. Additionally, this award provides support for two half-day 'mini-workshops', embedded within the GRC program structure, that focus on two important facets of the American Competitiveness Initiative (ACI), namely (1) partnerships among academia, industry, and national laboratories and (2) development of a diverse, well prepared workforce, and do so within the critical technology of fundamental and applied electrochemistry.\n\nBroader impacts of this activity include seeding the development of (1) a diverse workforce in the electrochemical sciences and (2) new partnerships that capture sector synergy in multidisciplinary electrochemical sciences in pursuit of ACI goals.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5475", "attributes": { "award_id": "0630969", "title": "Increasing Student Success in Biology & Biotechnology", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "S-STEM-Schlr Sci Tech Eng&Math" ], "program_reference_codes": [], "program_officials": [], "start_date": "2007-01-01", "end_date": "2011-06-30", "award_amount": 495863, "principal_investigator": { "id": 19077, "first_name": "E. Eileen", "last_name": "Gardner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1411, "ror": "https://ror.org/00k3ayt93", "name": "William Paterson University", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1411, "ror": "https://ror.org/00k3ayt93", "name": "William Paterson University", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "This project provides 12 full scholarships each year over four years to academically talented, low-income Biology and Biotechnology majors, and supports faculty-guided research experiences, tutoring, internships and field trips to industry settings for the scholarship recipients. The project goal is to increase retention and graduation rates, including accelerating degree completion by providing the means for current part-time students to pursue full-time study. The intellectual merit of the project is the preparation of an increased number of well-qualified biologists and biotechnologists, and helping students with the desire to succeed overcome academic disadvantages. The project is led by a Project Director and a Head Mentor with over 50 years of combined experience in teaching, promoting and supervising student research. Its broader impacts are increasing the supply of trained Biology and Biotechnology technicians to meet the growing demand for them in New Jersey (which is home to one of the largest concentrations of pharmaceutical, chemical and other biotechnology-based industries in the world), the region and the nation; and increasing the number of individuals who are members of groups currently underrepresented in these fields earning B.S. degrees. In recent years, 65% of our Biology and Biotechnology majors have been women, 19% have been Hispanic and 17% have been African-American. The success of the project is measured by its impact on closing gaps in the retention and graduation rates for these students compared to the overall rates for our Biology and Biotechnology majors over the past five years. Project results are disseminated through presentations and reports at national and regional meetings, with individual student successes publicized through University publications and press releases to regional media outlets.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5471", "attributes": { "award_id": "0602350", "title": "Collaborative Research: The Lake Malawi Drilling Project - A long, high-resolution record of abrupt climate change in the southern tropics of East Africa", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "GLOBAL CHANGE" ], "program_reference_codes": [], "program_officials": [], "start_date": "2006-09-15", "end_date": "2010-08-31", "award_amount": 224027, "principal_investigator": { "id": 19071, "first_name": "Andrew", "last_name": "Cohen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 438, "ror": "https://ror.org/03m2x1q45", "name": "University of Arizona", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 19069, "first_name": "David L", "last_name": "Dettman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 19070, "first_name": "Peter N", "last_name": "Reinthal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 438, "ror": "https://ror.org/03m2x1q45", "name": "University of Arizona", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "Drilling the large rift lakes of the East African Rift Valley has been a high priority goal since the 1980s. In 2005 the Lake Malawi Scientific Drilling Project acquired more than 623 m of core at two sites (92% recovery), in seven holes, including one hole in 600 meters of water that reached a subbottom depth of 380 m. The project triple-cored a high-resolution site in the north basin, which extends back 80kyr, double cored the deep site in the central basin covering the past 200 kyr, and single-cored the deep site to 380 m, dated at 1.5 million years at the base. These drill-cores represent the longest, continuous record of high-resolution climate change available in the continental tropics, and they offer the potential to secure high-fidelity signals of East African effective moisture and temperature at a scale of decades/centuries over the length of the core. Located at the southern end of the East African Rift Valley (9S-14S), Lake Malawi's great depth (max. of 700 m), extent (more than 580 km long), and prolonged stratification with anoxic bottom waters assure well preserved, at times laminated, sediments recording regionally-significant southern hemisphere climate signals. This grant 1) addresses specific paleoclimate questions posed below, and 2) completes the initial core descriptions over the full duration of the cored interval. The research will address these paleoclimate questions: What was the direction, magnitude and timing of effective moisture, wind, and temperature change of this southern tropical setting, on a millennial scale, during the past two glacialinterglacial cycles? Do the observed shifts coincide in a consistent manner with SST variability in the tropical oceans, or with the North Atlantic thermohaline circulation? What is the lake level history of Malawi, and how does it compare with the methane record of the polar ice cores, which is interpreted to be a globally averaged measure of tropical moisture on the continents? Does the observed evidence for abrupt climate change in the Lake Malawi and other parts of East Africa coincide with known events from other regions on Earth, e.g., Heinrich or Dansgaard/Oeschger events? What are the direction, duration and magnitude of these changes? What was the tropical climate behavior during earlier periods of global warmth (e.g. Marine Isotope Stage 5e, or alternatively MIS 11), and how abruptly did these periods begin and end?\nThe secondary objective is to complete the initial core descriptions, including reconnaissance sampling and analysis at low resolution over the past 1.5 million years. Did the climate of this site in the southern tropics respond only to changes in low-latitude precessional insolation (23-19 kyr) or also to high-latitude ice volume (100 kyr and 41 kyr) forcing, in the last part of the Pleistocene? Completing the reconnaissance, lowresolution analyses of this unique set of samples serves the greater scientific community, positioning it to undertake more elaborate studies on these cores in the future. Sampling and analyses are limited to key proxies, focused on quantifying past effective moisture, dust and temperature. Proxy analyses are carried out on a decade-century scale in the time intervals of selected events, and on a millennial scale over the broader intervals.\nThe broader impact of this research addresses the role of climate on human evolution, assists in interpreting the tectonic history of the East African Rift, and leads to a better understanding of the controls of climate on species evolution in lakes. For instance, new Malawi records as well as those from other African sites indicate a period of pronounced aridity prior to ~75 kyr. Was this aridity crisis responsible for the early human population bottleneck in evidence for that period? This collaborative project engages scholars in-training at the postdoctoral, graduate, and undergraduate levels, as well as African colleagues, and involves outreach components both in Africa and the U.S.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5477", "attributes": { "award_id": "0602453", "title": "Collaborative Research: The Lake Malawi Drilling Project - A long, high-resolution record of abrupt climate change in the southern tropics of East Africa", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "GLOBAL CHANGE" ], "program_reference_codes": [], "program_officials": [ { "id": 19087, "first_name": "Paul", "last_name": "Filmer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2006-09-15", "end_date": "2011-08-31", "award_amount": 340525, "principal_investigator": { "id": 19088, "first_name": "Christopher", "last_name": "Scholz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 579, "ror": "https://ror.org/025r5qe02", "name": "Syracuse University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 579, "ror": "https://ror.org/025r5qe02", "name": "Syracuse University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Drilling the large rift lakes of the East African Rift Valley has been a high priority goal since the 1980s. In 2005 the Lake Malawi Scientific Drilling Project acquired more than 623 m of core at two sites (92% recovery), in seven holes, including one hole in 600 meters of water that reached a subbottom depth of 380 m. The project triple-cored a high-resolution site in the north basin, which extends back 80kyr, double cored the deep site in the central basin covering the past 200 kyr, and single-cored the deep site to 380 m, dated at 1.5 million years at the base. These drill-cores represent the longest, continuous record of high-resolution climate change available in the continental tropics, and they offer the potential to secure high-fidelity signals of East African effective moisture and temperature at a scale of decades/centuries over the length of the core. Located at the southern end of the East African Rift Valley (9S-14S), Lake Malawi's great depth (max. of 700 m), extent (more than 580 km long), and prolonged stratification with anoxic bottom waters assure well preserved, at times laminated, sediments recording regionally-significant southern hemisphere climate signals. This grant 1) addresses specific paleoclimate questions posed below, and 2) completes the initial core descriptions over the full duration of the cored interval. The research will address these paleoclimate questions: What was the direction, magnitude and timing of effective moisture, wind, and temperature change of this southern tropical setting, on a millennial scale, during the past two glacialinterglacial cycles? Do the observed shifts coincide in a consistent manner with SST variability in the tropical oceans, or with the North Atlantic thermohaline circulation? What is the lake level history of Malawi, and how does it compare with the methane record of the polar ice cores, which is interpreted to be a globally averaged measure of tropical moisture on the continents? Does the observed evidence for abrupt climate change in the Lake Malawi and other parts of East Africa coincide with known events from other regions on Earth, e.g., Heinrich or Dansgaard/Oeschger events? What are the direction, duration and magnitude of these changes? What was the tropical climate behavior during earlier periods of global warmth (e.g. Marine Isotope Stage 5e, or alternatively MIS 11), and how abruptly did these periods begin and end?\nThe secondary objective is to complete the initial core descriptions, including reconnaissance sampling and analysis at low resolution over the past 1.5 million years. Did the climate of this site in the southern tropics respond only to changes in low-latitude precessional insolation (23-19 kyr) or also to high-latitude ice volume (100 kyr and 41 kyr) forcing, in the last part of the Pleistocene? Completing the reconnaissance, lowresolution analyses of this unique set of samples serves the greater scientific community, positioning it to undertake more elaborate studies on these cores in the future. Sampling and analyses are limited to key proxies, focused on quantifying past effective moisture, dust and temperature. Proxy analyses are carried out on a decade-century scale in the time intervals of selected events, and on a millennial scale over the broader intervals.\nThe broader impact of this research addresses the role of climate on human evolution, assists in interpreting the tectonic history of the East African Rift, and leads to a better understanding of the controls of climate on species evolution in lakes. For instance, new Malawi records as well as those from other African sites indicate a period of pronounced aridity prior to ~75 kyr. Was this aridity crisis responsible for the early human population bottleneck in evidence for that period? This collaborative project engages scholars in-training at the postdoctoral, graduate, and undergraduate levels, as well as African colleagues, and involves outreach components both in Africa and the U.S.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5480", "attributes": { "award_id": "0602404", "title": "Collaborative Research: The Lake Malawi Drilling Project - A long, high-resolution record of abrupt climate change in the southern tropics of East Africa", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Unknown", "GLOBAL CHANGE" ], "program_reference_codes": [], "program_officials": [], "start_date": "2006-09-15", "end_date": "2009-08-31", "award_amount": 45358, "principal_investigator": { "id": 19092, "first_name": "Kristina", "last_name": "Beuning", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1022, "ror": "", "name": "University of Wisconsin-Eau Claire", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1022, "ror": "", "name": "University of Wisconsin-Eau Claire", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "Drilling the large rift lakes of the East African Rift Valley has been a high priority goal since the 1980s. In 2005 the Lake Malawi Scientific Drilling Project acquired more than 623 m of core at two sites (92% recovery), in seven holes, including one hole in 600 meters of water that reached a subbottom depth of 380 m. The project triple-cored a high-resolution site in the north basin, which extends back 80kyr, double cored the deep site in the central basin covering the past 200 kyr, and single-cored the deep site to 380 m, dated at 1.5 million years at the base. These drill-cores represent the longest, continuous record of high-resolution climate change available in the continental tropics, and they offer the potential to secure high-fidelity signals of East African effective moisture and temperature at a scale of decades/centuries over the length of the core. Located at the southern end of the East African Rift Valley (9S-14S), Lake Malawi's great depth (max. of 700 m), extent (more than 580 km long), and prolonged stratification with anoxic bottom waters assure well preserved, at times laminated, sediments recording regionally-significant southern hemisphere climate signals. This grant 1) addresses specific paleoclimate questions posed below, and 2) completes the initial core descriptions over the full duration of the cored interval. The research will address these paleoclimate questions: What was the direction, magnitude and timing of effective moisture, wind, and temperature change of this southern tropical setting, on a millennial scale, during the past two glacialinterglacial cycles? Do the observed shifts coincide in a consistent manner with SST variability in the tropical oceans, or with the North Atlantic thermohaline circulation? What is the lake level history of Malawi, and how does it compare with the methane record of the polar ice cores, which is interpreted to be a globally averaged measure of tropical moisture on the continents? Does the observed evidence for abrupt climate change in the Lake Malawi and other parts of East Africa coincide with known events from other regions on Earth, e.g., Heinrich or Dansgaard/Oeschger events? What are the direction, duration and magnitude of these changes? What was the tropical climate behavior during earlier periods of global warmth (e.g. Marine Isotope Stage 5e, or alternatively MIS 11), and how abruptly did these periods begin and end?\nThe secondary objective is to complete the initial core descriptions, including reconnaissance sampling and analysis at low resolution over the past 1.5 million years. Did the climate of this site in the southern tropics respond only to changes in low-latitude precessional insolation (23-19 kyr) or also to high-latitude ice volume (100 kyr and 41 kyr) forcing, in the last part of the Pleistocene? Completing the reconnaissance, lowresolution analyses of this unique set of samples serves the greater scientific community, positioning it to undertake more elaborate studies on these cores in the future. Sampling and analyses are limited to key proxies, focused on quantifying past effective moisture, dust and temperature. Proxy analyses are carried out on a decade-century scale in the time intervals of selected events, and on a millennial scale over the broader intervals.\nThe broader impact of this research addresses the role of climate on human evolution, assists in interpreting the tectonic history of the East African Rift, and leads to a better understanding of the controls of climate on species evolution in lakes. For instance, new Malawi records as well as those from other African sites indicate a period of pronounced aridity prior to ~75 kyr. Was this aridity crisis responsible for the early human population bottleneck in evidence for that period? This collaborative project engages scholars in-training at the postdoctoral, graduate, and undergraduate levels, as well as African colleagues, and involves outreach components both in Africa and the U.S.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "5481", "attributes": { "award_id": "0602454", "title": "Collaborative Research: The Lake Malawi Drilling Project - A long, high-resolution record of abrupt climate change in the southern tropics of East Africa", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "GLOBAL CHANGE" ], "program_reference_codes": [], "program_officials": [ { "id": 19097, "first_name": "Paul", "last_name": "Filmer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2006-09-15", "end_date": "2009-08-31", "award_amount": 349902, "principal_investigator": { "id": 19100, "first_name": "Tom", "last_name": "Johnson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 740, "ror": "", "name": "University of Minnesota Duluth", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 19098, "first_name": "Christina D", "last_name": "Gallup", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 19099, "first_name": "Erik T", "last_name": "Brown", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 740, "ror": "", "name": "University of Minnesota Duluth", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "Drilling the large rift lakes of the East African Rift Valley has been a high priority goal since the 1980s. In 2005 the Lake Malawi Scientific Drilling Project acquired more than 623 m of core at two sites (92% recovery), in seven holes, including one hole in 600 meters of water that reached a subbottom depth of 380 m. The project triple-cored a high-resolution site in the north basin, which extends back 80kyr, double cored the deep site in the central basin covering the past 200 kyr, and single-cored the deep site to 380 m, dated at 1.5 million years at the base. These drill-cores represent the longest, continuous record of high-resolution climate change available in the continental tropics, and they offer the potential to secure high-fidelity signals of East African effective moisture and temperature at a scale of decades/centuries over the length of the core. Located at the southern end of the East African Rift Valley (9S-14S), Lake Malawi's great depth (max. of 700 m), extent (more than 580 km long), and prolonged stratification with anoxic bottom waters assure well preserved, at times laminated, sediments recording regionally-significant southern hemisphere climate signals. This grant 1) addresses specific paleoclimate questions posed below, and 2) completes the initial core descriptions over the full duration of the cored interval. The research will address these paleoclimate questions: What was the direction, magnitude and timing of effective moisture, wind, and temperature change of this southern tropical setting, on a millennial scale, during the past two glacialinterglacial cycles? Do the observed shifts coincide in a consistent manner with SST variability in the tropical oceans, or with the North Atlantic thermohaline circulation? What is the lake level history of Malawi, and how does it compare with the methane record of the polar ice cores, which is interpreted to be a globally averaged measure of tropical moisture on the continents? Does the observed evidence for abrupt climate change in the Lake Malawi and other parts of East Africa coincide with known events from other regions on Earth, e.g., Heinrich or Dansgaard/Oeschger events? What are the direction, duration and magnitude of these changes? What was the tropical climate behavior during earlier periods of global warmth (e.g. Marine Isotope Stage 5e, or alternatively MIS 11), and how abruptly did these periods begin and end?\nThe secondary objective is to complete the initial core descriptions, including reconnaissance sampling and analysis at low resolution over the past 1.5 million years. Did the climate of this site in the southern tropics respond only to changes in low-latitude precessional insolation (23-19 kyr) or also to high-latitude ice volume (100 kyr and 41 kyr) forcing, in the last part of the Pleistocene? Completing the reconnaissance, lowresolution analyses of this unique set of samples serves the greater scientific community, positioning it to undertake more elaborate studies on these cores in the future. Sampling and analyses are limited to key proxies, focused on quantifying past effective moisture, dust and temperature. Proxy analyses are carried out on a decade-century scale in the time intervals of selected events, and on a millennial scale over the broader intervals.\nThe broader impact of this research addresses the role of climate on human evolution, assists in interpreting the tectonic history of the East African Rift, and leads to a better understanding of the controls of climate on species evolution in lakes. For instance, new Malawi records as well as those from other African sites indicate a period of pronounced aridity prior to ~75 kyr. Was this aridity crisis responsible for the early human population bottleneck in evidence for that period? This collaborative project engages scholars in-training at the postdoctoral, graduate, and undergraduate levels, as well as African colleagues, and involves outreach components both in Africa and the U.S.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "7236", "attributes": { "award_id": "3P30AG028747-15S2", "title": "University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 11335, "first_name": "BASIL A", "last_name": "ELDADAH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2006-09-15", "end_date": "2021-06-30", "award_amount": 386092, "principal_investigator": { "id": 23031, "first_name": "JAY", "last_name": "MAGAZINER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 793, "ror": "", "name": "UNIVERSITY OF MARYLAND BALTIMORE", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23032, "first_name": "Emmanuel", "last_name": "Mongodin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23033, "first_name": "IRINA", "last_name": "TIMOFTE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 793, "ror": "", "name": "UNIVERSITY OF MARYLAND BALTIMORE", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": ": Identifying patients at risk for severe complications (i.e. respiratory failure, shock, or multiorgan dysfunction) following COVID-19 infection represents a critical challenge. The case fatality rate in COVID-19 indicates that older people are dying at a higher rate than other age groups, with 80 percent of deaths occurring in those older than 65 years. However, predicting disease severity in COVID-19 patients remains elusive. Humans co-exist with a vast and complex set of microbes (termed the microbiota) that extensively interact with the immune system and have the ability to trigger pro- or anti-inflammatory responses. Recent studies suggest that the host immune status is influenced by a fine balance of pro- and anti-inflammatory signals generated, in part, by the microbiota. This balance is most likely disrupted in patients with severe acute respiratory syndrome coronavirus (SARS-CoV-2). Given that previous studies have shown an association between inflammatory status of the patient and severity of the COVID-19 infection, characterizing the impact of the microbiota in SARS-CoV- 2 infection might prove critical to predict disease severity. The objective of this study is to define the association between the proinflammatory microbiome and the risk of developing ARDS in elderly patients with coronavirus infection admitted at University of Maryland School of Medicine. Our hypothesis is that pro-inflammatory microbiota is associated with airway epithelial destruction leading to severe coronavirus infection. The proposed work has the potential to identify pathway(s) involved in development of more severe complications of viral infection which can guide new treatments. This supplemental grant expands the current scope of University of Maryland Claude D. Pepper Center (UM- OAIC) research to identify new and critical microbiota-based targets for diagnostic and therapeutic applications, in order to improve outcomes and decrease disabilities in elderly patients diagnosed with Coronavirus infection. Our long-term goal is to develop novel microbiota-based targets for diagnostic applications and new treatments to reduce time on the ventilator, ICU and hospital stay with additional goals of rapid discharge home and return to a meaningful quality of life. We propose the following specific aims: SA1: Characterize the associations between human microbiota and ARDS in elderly patients infected with coronavirus. SA2: : Evaluate the T-cell repertoires, cytokine profiles associated with proinflammatory microbiota and ARDS in patients older than 65 in comparison with patients younger than 65 years old. SA3 : Evaluate if a proinflammatory microbiome is associated with worse outcomes (longer hospital length of stay and time on the ventilator) in comparison with anti-inflammatory microbiome.", "keywords": [ "2019-nCoV", "Adult", "Adult Respiratory Distress Syndrome", "American", "Anti-Inflammatory Agents", "Bacteria", "Bacteroidetes", "Bifidobacterium", "COVID-19", "Capsicum", "Case Fatality Rates", "Cessation of life", "Characteristics", "Clinical", "Complex", "Coronavirus", "Coronavirus Infections", "Critical Illness", "Death Rate", "Development", "Diagnosis", "Diagnostic", "Disease", "Distant", "Elderly", "Environment", "Equilibrium", "Failure", "Firmicutes", "Functional disorder", "Genome", "Goals", "Grant", "Health", "Home environment", "Hospitalization", "Hospitals", "Human", "Immune response", "Immune system", "Immunologics", "Incidence", "Infection", "Inflammatory", "Inflammatory Response", "Intensive Care Units", "Intubation", "Lactobacillus", "Length of Stay", "Lung", "Maryland", "Medical center", "Microbe", "Natural Immunity", "Nose", "Oral Characters", "Outcome", "Pathway interactions", "Patients", "Performance", "Phenotype", "Physiology", "Predisposition", "Process", "Property", "Prospective cohort", "Quality of life", "Reporting", "Research", "Respiratory Failure", "Risk", "SARS coronavirus", "Severities", "Severity of illness", "Shock", "Signal Transduction", "Site", "T cell response", "T-Lymphocyte", "Therapeutic", "Time", "United States", "Universities", "Ventilator", "Virus Diseases", "Work", "adaptive immunity", "age group", "aged", "airway epithelium", "base", "cytokine", "deconditioning", "disability", "fungal microbiota", "genetic element", "gut microbiota", "high risk", "human microbiota", "human old age (65+)", "immune activation", "immune system function", "immunological status", "improved", "improved outcome", "innovation", "insight", "interest", "lung injury", "medical schools", "member", "microbiome", "microbiota", "mortality", "mortality risk", "novel", "older patient", "pathogenic microbe", "patient population", "respiratory", "social" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1419, "count": 14184 } } }