Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=-other_investigators
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The conference will be preceded by a Gordon Research Seminar (GRS) for graduate students. Together, the two events will provide opportunities for researchers, especially young investigators and students, to present results of their research, meet senior experts in the field, and discuss emerging research trends in colloidal and polymeric solutions. These materials are important in a variety of technology areas including coatings, paints, personal-care products and cosmetics, and food processing. The goal of the GRC and GRS is to bring promote discussions that will enable comparisons between experiments, numerical simulations, and theory for these important materials.\n\nColloidal and polymer science, including polyelectrolytes, is growing in importance in a wide range of applications, especially those involving biotechnology. The development of RNA vaccines was enabled in part by creating nanoparticle complexes of DNA, a polyelectrolyte, with oppositely charged surfactants. Synthetic structures that mimic cells, such as membraneless organelles, are formed by segregating charged proteins that exhibit polyelectrolyte phase behavior. Increasing computing power, new computational methods, and high resolution experiments now allow comparisons between experiment and simulation at length and time scales that are accessible to both. This is the theme of the GRC/GRS. Session topics will include polyelectrolytes and ionic liquids, confined colloids, directed assembly, propelled colloids, interfacial systems, polymers and biology, polymer glasses, and driven elastomers. The GRS for graduate students will include technical sessions as well as career development sessions for students and young investigators.\n\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10485", "attributes": { "award_id": "1F30HL160055-01A1", "title": "The Use of Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injury", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26494, "first_name": "SEUNG KYOON KYOON", "last_name": "Woo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-05-01", "end_date": "2025-04-30", "award_amount": 49005, "principal_investigator": { "id": 26495, "first_name": "Dimitrios Chrisovalantou", "last_name": "Arhontoulis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract: As of August 4, 2021, COVID-19 has infected 35,286,935 people in the US with a mortality rate of 1.73%. One common COVID-19 induced complication is acute cardiac injury manifested by impaired cardiac function. These injuries have been associated with poor prognosis and increased mortality for COVID-19 patients. While acute cardiac injury is a major contributor to COVID-19 mortality, the underlying causes have not been elucidated. Among multiple factors (e.g., direct viral infection) that can contribute to COVID-19 induced cardiomyopathies, recent clinical data indicates that cytokine storm is a major contributor. COVID-19 infection initiates supraphysiological activation of the immune system, which leads to the release of inflammatory cytokines (e.g., IL-1E, IL-2, IL-6, IL-10, TNFD, G-CSF and MIP1D) into circulation, resulting in organ toxicity such as vascular instability and adverse cardiac events. Despite the critical roles of COVID-19 cytokine storm in acute cardiac injury, the current lack of animal and in vitro models has limited the mechanistic understanding and drug development. Further, while recent clinical data suggests that COVID-19 survivors with acute cardiac injuries can experience long-term cardiac abnormalities, outcome studies may take years to complete due to the novelty of this coronavirus. This highlights an unmet need to develop an effective model that can predict long- term cardiac outcomes of convalescent COVID-19 patients to provide guidance for clinical monitoring and therapeutic interventions. Our organoids provide a powerful platform to address this. The organoids are composed of hiPSC derived cardiomyocytes, human cardiac fibroblasts, human endothelial cells, and vascular supporting cells. The goal of this proposal is to develop an in vitro model for COVID-19 cytokine storm induced acute cardiac injuries by leveraging the innate inflammatory properties of cells (e.g., fibroblasts, endothelial cells) in the organoids, as these cells have been shown to produce various proinflammatory cytokines under stimulation. IL-1E is one of the first cytokines released from monocytes in response to viral infection and is known to induce IL-6 production, the central player in cytokine storm. The central hypothesis of this proposal is that IL-1E will induce cytokine storm in the organoids and recapitulate the COVID-19 induced acute cardiac injuries. This proposal is innovative in that we will harness a viral infection induced upstream cytokine stimulus (IL-1E) to initiate an endogenous inflammatory response to simulate cytokine storm in the organoids. Accordingly, we will pursue the two aims: 1) Use IL-1E treated cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries, determine the underlying mechanisms, and test the effects of immunomodulatory drugs, and 2) Use human cardiac organoids to assess the long-term cardiac complications of COVID-19 cytokine storm. The proposed research will establish an in vitro model system to elucidate the fundamental mechanisms of COVID- 19 cytokine storm induced cardiac injuries, demonstrate its validity for drug testing, and provide insights on the long-term cardiac effects of COVID-19 infection to guide clinical monitoring and therapeutic interventions.", "keywords": [ "3-Dimensional", "Actinin", "Acute", "Address", "Adipose tissue", "Adrenergic Agents", "Animals", "Autopsy", "Biological Models", "Blood Circulation", "Blood Vessels", "COVID-19", "COVID-19 complications", "COVID-19 cytokine storm", "COVID-19 impact", "COVID-19 mortality", "COVID-19 patient", "COVID-19 survivors", "CSF3 gene", "Calcium Signaling", "Cardiac", "Cardiac Myocytes", "Cardiomyopathies", "Cell Communication", "Cells", "Cessation of life", "Chronic", "Clinical", "Clinical Data", "Complication", "Coronavirus", "Data", "Dexamethasone", "Diffusion", "Disease model", "Dose", "EFRAC", "Endothelial Cells", "Event", "Fibroblasts", "Genetic Transcription", "Goals", "Heart", "Heart Abnormalities", "Heart Injuries", "Heart failure", "Human", "Hypoxia", "Immune system", "Immunomodulators", "Impairment", "In Situ Nick-End Labeling", "Inflammation", "Inflammatory", "Inflammatory Response", "Injury", "Interleukin-10", "Interleukin-2", "Interleukin-6", "Long-Term Effects", "Modeling", "Monitor", "Myocardial Infarction", "Myocardium", "Norepinephrine", "Organ", "Organoids", "Outcome", "Outcome Study", "Oxygen", "PECAM1 gene", "Persons", "Pharmacotherapy", "Phase", "Prevalence", "Production", "Prognosis", "Property", "Recovery", "Research", "Role", "SARS-CoV-2 infection", "Sampling", "Stimulus", "Stromal Cells", "Structure", "Supporting Cell", "System", "Testing", "Therapeutic Intervention", "Toxic effect", "Umbilical vein", "VWF gene", "Vimentin", "Virus Diseases", "combat", "cytokine", "cytokine release syndrome", "drug development", "drug testing", "experience", "heart function", "immune activation", "in vitro Model", "in vivo", "induced pluripotent stem cell derived cardiomyocytes", "innovation", "insight", "long term consequences of COVID-19", "monocyte", "mortality", "response", "stem cells", "transcriptome", "transcriptome sequencing" ], "approved": true } }, { "type": "Grant", "id": "10486", "attributes": { "award_id": "75N95021D00029-0-759502200002-1", "title": "SECURE PLATFORMS SUPPORT FOR THE N3C DATA ENCLAVE (COVID-19)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Advancing Translational Sciences (NCATS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-05-25", "end_date": "2022-09-24", "award_amount": 4000000, "principal_investigator": { "id": 26481, "first_name": "BRIAN", "last_name": "ZAVERTNIK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1737, "ror": "", "name": "PALANTIR TECHNOLOGIES, INC.", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "National COVID-19 Cohort Collaborative (N3C): The National COVID-19 Cohort Collaborative (N3C) sponsors the NIH COVID-19 Data Enclave, https://covid.cd2h.org/, one of the largest data enclaves in the world supporting COVID-19 research. N3C is a partnership among the NCATS-supported Clinical and Translational Science Awards (CTSA) Program hubs, the National Center for Data to Health (CD2H), and the NIGMS-supported Institutional Development Award Networks for Clinical and Translational Research (IDeA-CTR), with overall stewardship by NCATS. The N3C Data Enclave is a secure platform storing harmonized clinical data provided by more than 60 contributing members. The Enclave hosts over 670 million clinical observations on over 6.8 million persons, including over 2.2 million COVID cases, amounting to more than 7.8 billion rows of data. To protect privacy, this data consists only of limited data sets, de-identified data sets, and synthetic data sets; there is no personally identifiable information kept in the Enclave. The Enclave resides in the NCATS Secure Scientific Platforms Environment. The Environment is a specialized cloud-based data aggregation and analytics enclave that can integrate, manage, secure, and analyze any kind of scientific data, and provide secure, controlled access to internal and external collaborators. Within the Environment, multiple NIH ICs, Federal agencies, and Federal task forces integrate, manage, secure, and analyze all types of scientific data using dedicated platforms, and, equally importantly, make that data available in specific and controlled collaborations with each other and with external collaborators.", "keywords": [ "Advisory Committees", "Award", "COVID-19", "Clinical", "Clinical Data", "Clinical Research", "Clinical and Translational Science Awards", "Collaborations", "Data", "Data Aggregation", "Data Analytics", "Data Set", "Development", "Environment", "Health", "National Center for Advancing Translational Sciences", "National Institute of General Medical Sciences", "Personally Identifiable Information", "Persons", "Privacy", "Research", "Secure", "Translational Research", "United States National Institutes of Health", "cloud based", "cohort", "coronavirus disease", "data de-identification", "data enclave", "member", "programs" ], "approved": true } }, { "type": "Grant", "id": "10487", "attributes": { "award_id": "3R00AT009466-04S1", "title": "Affective Sensory Pathways of Light Stroking and Deep Pressure Touch", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Complementary and Integrative Health (NCCIH)" ], "program_reference_codes": [], "program_officials": [ { "id": 26496, "first_name": "Alexander H.", "last_name": "Tuttle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-06-01", "end_date": "2023-11-30", "award_amount": 219375, "principal_investigator": { "id": 26497, "first_name": "Laura K", "last_name": "Case", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 760, "ror": "https://ror.org/0168r3w48", "name": "University of California, San Diego", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Administrative Supplement Proposal: Abstract R00 AT009466: Affective Sensory Pathways of Light Stroking and Deep Pressure Touch Dr. Case is as an Assistant Professor in the Department of Anesthesiology at the University of California San Diego (UC San Diego). After overcoming covid-related delays, her R00 study on mechanisms of affective touch is running smoothly and on track with her current SARP. The proposed administrative supplement is requested to add two highly innovative aims to increase the impact of the originally proposed study in establishing novel mechanisms of action for sensory-based complementary approaches such as massage therapy. The existing R00 study seeks to identify factors underlying blunted affective touch perception in individuals with chronic pain, and to compare the pain-relieving mechanisms and effects of light gentle stroking and deep pressure between patients with Fibromyalgia (FM) and healthy controls. The current administrative proposal adds two aims: 5) Determine the local effect of subcutaneous OT on experimental pain and 6) Determine the local effect of subcutaneous OT on touch pleasantness. Recent research in rodents demonstrates that oxytocin strongly modulates C-fibers in the spinal cord and at the terminal axon. In humans, systemic oxytocin modulates affective touch perception, and skin injection reduces postsurgical pain. However, peripheral effects of oxytocin on affective touch perception have never been tested in humans. Study results are expected to significantly impact fundamental understanding of the mechanisms of peripheral pathways for touch pleasantness and pain reduction. We expect this project to lead to a competitive R01 submission to test whether local effects of oxytocin differ in patients with chronic pain, who exhibit C-nociceptor sensitization and reduced touch pleasantness. This contribution will inform subsequent research on mechanisms of manual touch therapies and provide a new direction to test differences in individuals with chronic pain.", "keywords": [ "Acute Pain", "Administrative Supplement", "Adult", "Affective", "Analgesics", "Anesthesiology", "Anxiety", "Area", "Attention", "Blood", "C Fiber", "California", "Clinical Treatment", "Cross-Over Studies", "Dorsal", "Dose", "Double-Blind Method", "Emotional", "Enrollment", "Enzyme-Linked Immunosorbent Assay", "Esthesia", "Exhibits", "Forearm", "Fright", "Heart Rate", "Human", "Immunoassay", "Individual", "Injections", "Institutional Review Boards", "Insula of Reil", "Isotonic Exercise", "Lead", "Light", "Manipulative Therapies", "Manuals", "Massage", "Measures", "Mechanics", "Mechanoreceptors", "Mediating", "Mediator of activation protein", "Moods", "Mus", "Nerve", "Neurons", "Neuropeptides", "Nociception", "Nociceptors", "Opioid Antagonist", "Oxytocin", "Oxytocin Receptor", "Pain", "Pain Threshold", "Pain intensity", "Participant", "Pathway interactions", "Perception", "Peripheral", "Placebos", "Postoperative Pain", "Predictive Factor", "Presynaptic Terminals", "Process", "Research", "Rodent", "Role", "Running", "Saline", "Sensory", "Skin", "Spinal Cord", "Spinal Ganglia", "Stimulus", "Stress", "Tactile", "Testing", "Therapeutic tactile stimulation", "Touch sensation", "Transcranial magnetic stimulation", "Universities", "autism spectrum disorder", "base", "chronic pain", "chronic pain management", "chronic pain patient", "coronavirus disease", "experience", "fibromyalgia patients", "injured", "innovation", "light effects", "nerve injury", "novel", "pain behavior", "pain model", "pain perception", "pain reduction", "pain relief", "painful neuropathy", "peripheral pain", "pressure", "professor", "programs", "social", "subcutaneous", "tactile stimulation", "theories", "trait" ], "approved": true } }, { "type": "Grant", "id": "10488", "attributes": { "award_id": "3U24HG007051-09S1", "title": "Intergrated Biorepository of H3Africa Uganda", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26498, "first_name": "Jennifer L", "last_name": "Troyer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-06-01", "end_date": "2023-05-31", "award_amount": 320069, "principal_investigator": { "id": 22443, "first_name": "Moses Lutaakome", "last_name": "Joloba", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1116, "ror": "https://ror.org/03dmz0111", "name": "Makerere University", "address": "", "city": "", "state": "", "zip": "", "country": "UGANDA", "approved": true }, "abstract": "Summary/Abstract Background: The availability of high quality well annotated biological and environmental specimens for research purposes requires the development of standardised methods for collection, processing, long-term storage, retrieval and distribution of specimens that will enable their future use for research. For this reason, the NIH (in 2013) together with Makerere University established the Integrated Biorepository of H3Africa in Uganda (IBRH3AU), a state-of-the-art facility for sample collection, processing, storage, retrieval and distribution for genomic research for the H3Africa Consortium and other researchers. In the past 10 years, the IBRH3AU has stored samples from both H3Africa researchers and other researchers. The biorepository has been instrumental in the response to COVID-19 through establishment of COVID-19 biobank that was key in providing samples for rapid evaluation of COVID-19 diagnostic Kits and availing samples to the biotech companies developing COVID-19 vaccines, therapeutics and diagnostics in Uganda and beyond. As the H3Africa project draws to the end, the Uganda biorepository has critical pending unfunded activities. The overall goal of this administrative supplement request is to ensure the key pending activities are completed. H3Africa projects within Eastern and Central Africa who are finalising with project activities will be able to complete sample deposition to the biorepository. Through the supplement the biorepository will be able to continue processing, storage and distribution of samples to researchers. In addition, there is need for additional funding to analyse the samples of environmental exposure that have been collected and stored in the Uganda Biorepository. Due to COVID-19, the procurement of equipment for analysis of the environmental exposure samples was delayed. The supplement will be useful in further consolidation of our sustainability plan Approach: (a) The Uganda H3Africa Biorepository will use the funding from the supplement to continue to support the H3Africa researchers to finalise sample shipment, processing, storage and distribution. Quality controlled and assured biorepository services will be offered as per ISO 20387 biobanking standard, ISBER best practices and standards, in line with H3Africa Data and Biospecimen Accession (DBAC) policies, (b) In addition to existing and implemented protocols for genomic analyses (Nucleic acid [DNA and RNA] extraction and purification from blood and its derivatives), protocols, Standard operating procedures and practices have been developed and implemented for collecting and storage of samples for environmental exposures (tobacco smoke, trace elements, perfluoroalkyl and polyfluoroalkyl substances, metabolites of pesticides, toxins from mold, polycyclic aromatic hydrocarbon metabolites, volatile organic compounds, etc.) The stored samples are yet to be analysed. The supplement will provide us with a chance to analyse these samples and reveal the extent of the burden in this setting. (c) Through continued implementation of our business plan to ensure sustainability, the biorepository will remain a true scientific transformatory resource beyond H3Africa project. Expected Benefits: • Ensure logical conclusion of H3Africa project activities as the biorepositories collect and store the remaining samples. • Enable analysis of stored samples of environmental exposures to estimate the magnitude of the problem in Uganda • Continue to consolidate the sustainability plan for the Uganda Biorepository", "keywords": [ "AIDS/HIV problem", "Accreditation", "Address", "Administrative Supplement", "Africa", "African", "Aromatic Polycyclic Hydrocarbons", "Awareness", "Bioinformatics", "Biological", "Biotechnology", "Blood", "Businesses", "COVID-19", "COVID-19 diagnostic", "COVID-19 vaccine", "Central Africa", "Collection", "Color", "Communicable Diseases", "Communities", "DNA", "Data", "Deposition", "Development", "Diabetes Mellitus", "Diagnostic", "Diagnostic Reagent Kits", "Dideoxy Chain Termination DNA Sequencing", "Eastern Africa", "Ensure", "Environment", "Environmental Exposure", "Enzyme-Linked Immunosorbent Assay", "Equipment", "Evaluation", "Exposure to", "Flow Cytometry", "Funding", "Future", "Genes", "Genetic", "Genomics", "Goals", "Health", "Heart Diseases", "Heredity", "High Pressure Liquid Chromatography", "Human", "Hunger", "Hypertension", "Immunology", "Infrastructure", "Laboratories", "Life Style", "Malaria", "Malignant Neoplasms", "Methods", "Microbiology", "Molds", "Molecular Biology", "Nucleic Acids", "Outcome", "Participant", "Patient Recruitments", "Pesticides", "Policies", "Poly-fluoroalkyl substances", "Population", "Procedures", "Process", "Protocols documentation", "RNA", "Research", "Research Personnel", "Research Project Grants", "Research Training", "Resources", "Retrieval", "Sampling", "Science", "Service provision", "Services", "Ships", "Southern Africa", "Specimen", "Standardization", "Students", "System", "Temperature", "Therapeutic", "Time", "Tobacco smoke", "Toxin", "Trace Elements", "Training", "Uganda", "United States National Institutes of Health", "Universities", "Western Africa", "biobank", "equipment acquisition", "genomic data", "repository", "response", "sample collection", "sequencing platform", "volatile organic compound" ], "approved": true } }, { "type": "Grant", "id": "10489", "attributes": { "award_id": "3U01HG007044-09S1", "title": "Clinical and genetic studies of hereditary neurological disorders in Mali", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26498, "first_name": "Jennifer L", "last_name": "Troyer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-06-01", "end_date": "2023-06-30", "award_amount": 213529, "principal_investigator": { "id": 26499, "first_name": "GUIDA", "last_name": "LANDOURE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1519, "ror": "", "name": "UNIV OF SCIENCES, TECH & TECH OF BAMAKO", "address": "", "city": "", "state": "", "zip": "", "country": "MALI", "approved": true }, "abstract": "Despite the vast diversity of its populations, genetic studies in Africa have been limited. African populations, Malians in particular, have a high rate of intra-ethnic and consanguineous marriage, resulting in increased prevalence of autosomal recessive diseases. Family-based genetic studies can be limited in developed countries due to small sib ships. The average fertility rate in Mali is over 6 births per woman, offering a unique opportunity to find new disease genes or mutations that can then be studied in other populations. Neurological disorders present public health challenges globally with total disability- adjusted life years (DALYs) greater than some infectious diseases. These challenges are even greater when considering hereditary neurological diseases that cause premature death, severe disability and loss of productivity, resulting in high health care costs. Although most are currently untreatable, increasing awareness and community engagement about hereditary neurological disorders can reduce this burden. With previous awards, we have established the molecular defects in several families and identified variants in novel genes for which functional experiments are still underway. Through genetic counseling and community engagement session, patients and families as well as their communities have gained knowledge regarding the cause of these diseases; lifting in part the psychosocial burden, and orienting their partner choice. However, several families haven’t received their results due to covid-19-related issues or incomplete genetic and functional analyses. In addition, community engagement activities were not completed, especially in areas with high consanguinity. The creation of rare disease patients’ association is an asset to accomplish this objective. Sequencing data analysis in several other families has been inconclusive, necessitating reanalysis or genotyping of additional family members to come to a diagnosis. The infrastructures built with the previous award have created a suitable environment to perform state-of-art research and train the next generation African scientists. However, students and fellows haven’t finished their in- or out of country training due to delays. To keep research current in Africa, there is a need to complete the training of these next-generation scientists.", "keywords": [ "Affect", "Africa", "Africa South of the Sahara", "African", "Area", "Award", "Awareness", "Biology", "Birth", "COVID-19", "Cell Culture Techniques", "Cessation of life", "Clinical", "Clinical Research", "Communicable Diseases", "Communities", "Consanguinity", "Country", "Data Analyses", "Defect", "Developed Countries", "Diagnosis", "Disease", "Ensure", "Environment", "Family", "Family member", "Fertility Rates", "Funding", "Future Generations", "Gene Mutation", "General Population", "Genes", "Genetic", "Genetic Counseling", "Genetic Diseases", "Genetic Services", "Genetic study", "Genotype", "Goals", "Health", "Health Care Costs", "Human Inbreeding", "Individual", "Infrastructure", "Inherited", "Knowledge", "Lead", "Lifting", "Local Government", "Mali", "Medical Genetics", "Modeling", "Molecular", "Molecular Biology", "Mutation", "Neurologic", "Patients", "Phenotype", "Physicians", "Politics", "Population", "Population Genetics", "Prevalence", "Productivity", "Public Health", "Rare Diseases", "Reporting", "Research", "Research Training", "Resources", "Scientist", "Ships", "Specialist", "Students", "Therapeutic", "Training", "Ursidae Family", "Variant", "Vulnerable Populations", "Woman", "Work", "base", "care seeking", "community engagement", "disability", "disability-adjusted life years", "disease-causing mutation", "exome sequencing", "experimental study", "genetic testing", "genetic variant", "interest", "literacy", "neglect", "nervous system disorder", "next generation", "novel", "premature", "prevent", "productivity loss", "psychosocial", "rare genetic disorder", "social factors", "social stigma" ], "approved": true } }, { "type": "Grant", "id": "10491", "attributes": { "award_id": "3R33AT010125-03S2", "title": "Effect of Mindfulness Training on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8626, "first_name": "Wendy J.", "last_name": "Weber", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2023-08-31", "award_amount": 700000, "principal_investigator": { "id": 23249, "first_name": "Zev David", "last_name": "Schuman Olivier", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1582, "ror": "https://ror.org/059c3mv67", "name": "Cambridge Health Alliance", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1582, "ror": "https://ror.org/059c3mv67", "name": "Cambridge Health Alliance", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Opioid Use Disorder (OUD) is a national health crisis. Office-Based Opioid Treatment (OBOT) with buprenorphine/naloxone (B/N) prevents overdose deaths. Psychosocial stress and psychiatric problems (e.g., Anxiety) are major reasons for OBOT drop out and relapse. Many patients turn to benzodiazepines (BZD) to address anxiety and emotional distress with dangerous consequences. Nonpharmacologic approaches to anxiety, stress, and emotion dysregulation are needed during primary care OBOT, which is the primary access point for OUD treatment in most US counties. Mindfulness-Based Interventions (MBI) safely and reliably reduce the impact of stress, anxiety, depression, and chronic pain, which could increase OBOT retention, while reducing rates of relapse and overdose deaths. However, current 8-week standard MBIs do not appear to have strong, sustained impact on substance use outcomes, suggesting longer or enhanced MBIs are needed in the OUD treatment setting. This project originally proposed to adapt, refine, and compare the effectiveness of the 6-month live-online Mindful Recovery OUD Care Continuum (M-ROCC) versus a standard recovery group in primary care. M-ROCC is derived from the evidence-based, established Mindfulness Training for Primary Care (MTPC) program, which has been adapted for Opioid Use Disorder. M-ROCC includes a flexible, patient-centered, motivationally responsive design, including a Low Dose Mindfulness Entry Group, Mindfulness Maintenance Check-in Support Group, and an intensive Mindfulness Training for Primary Care (MTPC-OUD) Group. M-ROCC builds on the previously demonstrated ascending mindfulness practice dose ladder approach, which helps individuals with OUD nurture motivation and resolve ambivalence for mindfulness practice. MTPC has been shown to lower anxiety, stress, and depression, while increasing self-efficacy and capacity for behavioral change by engaging self-regulation mechanisms. During the R21 phase, we established the feasibility and acceptability of the M-ROCC program and prepared for the R33 phase by training providers and obtaining necessary approvals and site contracts. In the R33 phase, we planned to conduct a five-site RCT comparing M-ROCC versus Group-Based Opioid Treatment (GBOT). Due to the COVID-19 pandemic, we modified all aspects of the R33 phase to be conducted with a national sample in a remote, live-online, virtual format, comparing M-ROCC versus a standard online recovery group for 196 patients prescribed B/N for OUD, primarily evaluating its impact on opioid use and anxiety. We all evaluate effects on cocaine and BZD use, as well as aspects of self-regulation needed for sustained addiction recovery. Participants in the online clinical trial are recruited from multiple U.S. states through provider outreach and social media advertising.", "keywords": [ "Abstinence", "Address", "Advertising", "Alcohols", "Anxiety", "Behavioral", "Benzodiazepines", "COVID-19 pandemic", "Cannabis", "Characteristics", "Clinical Trials", "Cocaine", "Code", "Continuity of Patient Care", "Contracts", "County", "Dangerousness", "Databases", "Dose", "Drops", "Enrollment", "Facebook", "Generations", "Geography", "Health", "Hearing", "Illicit Drugs", "Individual", "Informal Social Control", "Information Systems", "Maintenance", "Measurement", "Measures", "Mental Depression", "Mindfulness Training", "Motivation", "Opioid", "Outcome", "Pain interference", "Participant", "Patient Outcomes Assessments", "Patient Self-Report", "Patients", "Phase", "Primary Health Care", "Provider", "Psychosocial Stress", "Recovery", "Recovery Support", "Relapse", "Rural", "Rural Community", "Sampling", "Self Efficacy", "Site", "Stress", "Suboxone", "Support Groups", "Telemedicine", "Training", "acceptability and feasibility", "addiction", "base", "buprenorphine treatment", "chronic pain", "clinically relevant", "cocaine use", "comparative effectiveness trial", "compare effectiveness", "design", "emotion dysregulation", "emotional distress", "evidence base", "flexibility", "illicit opioid", "mindfulness", "mindfulness intervention", "opioid mortality", "opioid use", "opioid use disorder", "outreach", "overdose death", "patient oriented", "prevent", "programs", "recruit", "social media", "substance use", "virtual" ], "approved": true } }, { "type": "Grant", "id": "10492", "attributes": { "award_id": "1F30AI172230-01", "title": "Evolution, transmission, and clinical impacts of SARS-CoV-2 variants among urban and rural populations", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6588, "first_name": "MICHAEL JOHN", "last_name": "Cooper", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-07-01", "end_date": "2026-06-30", "award_amount": 39032, "principal_investigator": { "id": 26500, "first_name": "Cynthia Y", "last_name": "Tang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1049, "ror": "", "name": "UNIVERSITY OF MISSOURI-COLUMBIA", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has resulted in over 5 million deaths worldwide. As the burdens of the pandemic in the United States (US) shift from urban to rural communities, preliminary studies suggest that rural populations suffer from higher disease severity and mortality rates than urban populations. However, even while 20% of the US population lives in a rural area and rural populations have known risk factors that differ from urban populations, the majority of COVID-19 research has primarily focused on large urban centers, and disease mitigation efforts in rural communities are largely informed by urban-centric data. Thus, it is urgently necessary to understand the evolution, spread, and clinical impacts of SARS-CoV-2 variants in rural areas and the disease interactions among urban and rural regions. However, limited clinical and genomic data, particularly from rural areas, are available, preventing us from fully understanding the disease dynamics of COVID-19. The objectives of this training grant are to determine how SARS-CoV-2 variants emerge and spread among urban and rural communities and to determine the virus, host, and population factors associated with clinical outcomes while training an MD-PhD student in advanced bioinformatics approaches, translational study design, and computational thinking to become an independent physician scientist. The Central Hypotheses are that SARS-CoV-2 variants arise in urban centers and spread into rural environments and that a synergistic set of virus, host, and population factors are associated with disease severity. To test our hypotheses, two specific aims are proposed to determine the genetic diversity and spread of SARS-CoV-2 variants among urban and rural regions (Aim 1) and to model clinical impacts of host, SARS-CoV-2 virus, and population factors (Aim 2). An existing and ongoing multi-year dataset that includes clinical information and whole genome sequencing of COVID-19-positive samples of individuals from urban and rural regions of Missouri will be used in both aims. This proposal is submitted in response to the NIAID Strategic Plan for COVID-19 Research Priority 1, “Assess functional consequences of newly emerging SARS-CoV-2 variants.” We expect the results from this study to support this priority in two ways: 1) We will determine the transmission patterns of SARS-CoV-2 variants between urban and rural communities, and 2) We will determine the clinical implications of existing and emerging SARS-CoV-2 variants as they interact with various other virus and host factors. The results from this project will improve the understanding of SARS-CoV-2 transmission dynamics and clinical impacts, particularly among rural populations, which will be important for the mitigation of COVID-19 and future pandemics.", "keywords": [ "2019-nCoV", "Algorithms", "Bayesian Analysis", "Bioinformatics", "COVID-19", "COVID-19 impact", "COVID-19 pandemic", "COVID-19 severity", "COVID-19 vaccination", "Catchment Area", "Cessation of life", "Cities", "Classification", "Clinical", "Clinical Data", "Data", "Data Set", "Disease", "Disease Outcome", "Economic Burden", "Epidemiologic Factors", "Epidemiology", "Evolution", "Fellowship", "Future", "Genetic Variation", "Genome", "Genomic approach", "Genomics", "Geographic Factor", "Geographic Information Systems", "Geography", "Goals", "Grant", "Healthcare Systems", "Individual", "Integration Host Factors", "Knowledge", "Lasso", "Linear Regressions", "Machine Learning", "Medical center", "Midwestern United States", "Missouri", "Modeling", "Mutation", "Mutation Analysis", "National Institute of Allergy and Infectious Disease", "Outcome", "Patients", "Pattern", "Phylogenetic Analysis", "Physicians", "Population", "Property", "Research", "Research Design", "Research Priority", "Risk Factors", "Rural", "Rural Community", "Rural Population", "SARS-CoV-2 positive", "SARS-CoV-2 transmission", "SARS-CoV-2 variant", "Sampling", "Scientist", "Severity of illness", "Statistical Models", "Strategic Planning", "Testing", "Training", "United States", "Urban Community", "Urban Population", "Variant", "Viral Load result", "Virus", "base", "comorbidity", "comparative", "computational reasoning", "design", "disease transmission", "doctoral student", "experience", "genome sequencing", "genomic data", "health care economics", "improved", "information system analysis", "mortality", "multi-task learning", "nasopharyngeal swab", "novel", "pandemic disease", "prevent", "response", "rural area", "rural counties", "rural disparities", "rural environment", "social structure", "socioeconomics", "translational approach", "translational study", "transmission process", "urban area", "whole genome" ], "approved": true } }, { "type": "Grant", "id": "10493", "attributes": { "award_id": "1R35GM146859-01", "title": "Endothelial regulation of inflammation in trauma and hemorrhagic shock", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22508, "first_name": "CHIEN-CHUNG", "last_name": "Chao", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-01", "end_date": "2027-05-31", "award_amount": 390000, "principal_investigator": { "id": 26501, "first_name": "Jessica", "last_name": "Cardenas", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 788, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Complications that arise secondary to an exaggerated innate immune response, such as multiple organ failure, are a major cause of late-stage mortality in trauma patients. My overall goal is to initiate an innovative and translational research program focused on elucidating mechanisms through which the vascular endothelium regulates the host inflammatory response to severe trauma. In particular, my research is focused on the immunomodulatory functions of the antithrombin (AT)-heparan sulfate system. AT elicits anti-inflammatory signaling upon binding to specific heparan sulfate proteoglycan (HSPG) receptors on the endothelial surface that contain a 3-0-sulfate (3-0S) modification. Our ongoing experiments demonstrate that dysregulation of the ATHSPG system is a novel mechanism driving inflammation and organ injury following severe trauma and hemorrhagic shock. However, the mechanisms that govern 3-0S HSPG expression and AT binding following trauma is a major knowledge gap in the field. Understanding these mechanisms will enable us to develop novel clinical tools to attenuate aberrant inflammation following trauma and treat or prevent subsequent organ failure. The next 5 years of my proposed research program will focus on 3 developing programmatic areas that seek to elucidate 1) mechanisms that mediate 3-0S HSPG degradation; 2) mechanisms that regulate 3-0S HSPG biosynthesis; and 3) the biological role and therapeutic potential of unique AT variants capable of regulating inflammation when 3-0S HSPG expression is reduced. Results of these investigations have broad-reaching implications for many conditions in which inflammation contributes to the pathogenesis, such as sepsis, transplantation, and COVID-19. Funding from this R35 award will 1) enable the establishment of my highly innovative, long-term research program that is guided by the NIGMS mission; 2) advance our basic understanding of the host inflammatory response to trauma; and 3) create novel therapeutics to improve longterm survival and quality of life for the critically ill.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "10495", "attributes": { "award_id": "75N93022C00047-0-9999-1", "title": "REAL-TIME SURVEILLANCE OF VACCINE MISINFORMATION FROM SOCIAL MEDIA PLATFORMS", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-08-08", "end_date": "2023-08-07", "award_amount": 300000, "principal_investigator": { "id": 26502, "first_name": "JINGCHENG", "last_name": "DU", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1763, "ror": "", "name": "MELAX TECHNOLOGIES, INC.", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "To develop digital tools to identify and combat malicious digital bots that spread misinformation about infectious disease treatments and vaccines, including COVID-19 vaccines.", "keywords": [ "Basic Science", "COVID-19 vaccine", "Coronavirus", "Misinformation", "Severe Acute Respiratory Syndrome", "Time", "Vaccines", "combat", "digital", "infectious disease treatment", "social media", "tool" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1424, "count": 14236 } } }