Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=-funder
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-funder", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-funder", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-funder", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=-funder" }, "data": [ { "type": "Grant", "id": "14441", "attributes": { "award_id": "2127506", "title": "Collaborative Research: Building consensus around the quantification and interpretation of Symbiodiniaceae diversity", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "BIOLOGICAL OCEANOGRAPHY" ], "program_reference_codes": [], "program_officials": [ { "id": 6265, "first_name": "Daniel J.", "last_name": "Thornhill", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 82230, "principal_investigator": { "id": 29867, "first_name": "Sarah", "last_name": "Davies", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 168, "ror": "", "name": "Trustees of Boston University", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Single-celled microorganisms are highly diverse and play various roles in the function of natural ecosystems, but it is challenging to recognize how genetic, morphological, and physiological diversity relate to each other in microbial groups. In an exemplary case, micro-algae in the family Symbiodiniaceae comprise many species that can only be distinguished using molecular data. Symbiodinaceae function as symbionts of various marine invertebrates, but are perhaps best known as the key to coral reef ecosystem health and persistence. The team is hosting a virtual workshop in August 2021 to identify and build further consensus among experts regarding the assessment of Symbiodiniaceae diversity. By formalizing consensus approaches and disseminating them broadly, this workshop is creating a more collaborative and welcoming research community and ensuring that all current researchers, as well as those entering the field, feel confident applying for grants, conducting research, and publishing papers that incorporate work on Symbiodiniaceae diversity. This workshop is defining additional forward-thinking research priorities that anticipate methodological advances over the next 5-10 years. <br/><br/>Resolving the molecular diversity of microorganisms is a major technical challenge, particularly for dinoflagellates in the family Symbiodiniaceae. These micro-algal endosymbionts that associate with corals and other marine invertebrates feature massive genomes, high repeat content, and other unique aspects that have hindered their molecular characterization. As sequencing technologies have advanced, so too has our understanding of Symbiodiniaceae diversity, which has grown from the presumption of one widespread species in the 1960s to now encompass fifteen divergent genera and likely hundreds of species. This process of discovery has been fraught with controversy, as the most useful phylogenetic marker–the hyperdiverse internal transcribed spacer 2 (ITS2) region–is frustratingly difficult to interpret in a consistent manner. The ribosomal array is multicopy, it evolves at different rates in different lineages, and it is subject to concerted evolution, all of which complicate phylogenetic reconstructions. Moreover, sampled coral tissues contain populations of symbiont cells that can potentially be from multiple Symbiodiniaceae taxa, complicating efforts to characterize partner specificity. Early debates focused on the extent to which unique ITS2 sequences indicated the presence of multiple symbiont species or simply multiple intraspecific variants. This central conflict has led to different schools of thought about how flexible coral-algal associations can be, and how they might respond to ongoing climate change. Next-generation sequencing has provided more data, but the same foundational interpretive issues remain. This team is gathering pioneering Symbiodiniaceae experts from around the world (ranging from seasoned veterans to newly-minted PhDs) who all collectively agree that a consensus interpretive framework can and must be identified and advanced in order to move the field forward. The participants are generating a ‘consensus road map’ leading to two workshop products: 1. an NSF white paper; and 2. an open-access, peer-reviewed manuscript. Through pre-workshop surveys, four workshop sessions, post-workshop collaboration, and publication, the team is summarizing current practices and recommending key methods for identifying and analyzing Symbiodiniaceae genetic diversity across three ‘umbrellas’: 1. communities, 2. populations, and 3. strains. The written products from this workshop are being distributed to the wider reef and conservation community by leveraging a separate mini-workshop previously developed for the 2022 International Coral Reef Symposium. Workshop participants are also highlighting new technologies and research priorities for the next decade that should help fill some of the remaining knowledge gaps.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14442", "attributes": { "award_id": "2127508", "title": "Collaborative Research: Building consensus around the quantification and interpretation of Symbiodiniaceae diversity", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "BIOLOGICAL OCEANOGRAPHY" ], "program_reference_codes": [], "program_officials": [ { "id": 6265, "first_name": "Daniel J.", "last_name": "Thornhill", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 28222, "principal_investigator": { "id": 31067, "first_name": "John", "last_name": "Parkinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 235, "ror": "https://ror.org/032db5x82", "name": "University of South Florida", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "Single-celled microorganisms are highly diverse and play various roles in the function of natural ecosystems, but it is challenging to recognize how genetic, morphological, and physiological diversity relate to each other in microbial groups. In an exemplary case, micro-algae in the family Symbiodiniaceae comprise many species that can only be distinguished using molecular data. Symbiodinaceae function as symbionts of various marine invertebrates, but are perhaps best known as the key to coral reef ecosystem health and persistence. The team is hosting a virtual workshop in August 2021 to identify and build further consensus among experts regarding the assessment of Symbiodiniaceae diversity. By formalizing consensus approaches and disseminating them broadly, this workshop is creating a more collaborative and welcoming research community and ensuring that all current researchers, as well as those entering the field, feel confident applying for grants, conducting research, and publishing papers that incorporate work on Symbiodiniaceae diversity. This workshop is defining additional forward-thinking research priorities that anticipate methodological advances over the next 5-10 years. <br/><br/>Resolving the molecular diversity of microorganisms is a major technical challenge, particularly for dinoflagellates in the family Symbiodiniaceae. These micro-algal endosymbionts that associate with corals and other marine invertebrates feature massive genomes, high repeat content, and other unique aspects that have hindered their molecular characterization. As sequencing technologies have advanced, so too has our understanding of Symbiodiniaceae diversity, which has grown from the presumption of one widespread species in the 1960s to now encompass fifteen divergent genera and likely hundreds of species. This process of discovery has been fraught with controversy, as the most useful phylogenetic marker–the hyperdiverse internal transcribed spacer 2 (ITS2) region–is frustratingly difficult to interpret in a consistent manner. The ribosomal array is multicopy, it evolves at different rates in different lineages, and it is subject to concerted evolution, all of which complicate phylogenetic reconstructions. Moreover, sampled coral tissues contain populations of symbiont cells that can potentially be from multiple Symbiodiniaceae taxa, complicating efforts to characterize partner specificity. Early debates focused on the extent to which unique ITS2 sequences indicated the presence of multiple symbiont species or simply multiple intraspecific variants. This central conflict has led to different schools of thought about how flexible coral-algal associations can be, and how they might respond to ongoing climate change. Next-generation sequencing has provided more data, but the same foundational interpretive issues remain. This team is gathering pioneering Symbiodiniaceae experts from around the world (ranging from seasoned veterans to newly-minted PhDs) who all collectively agree that a consensus interpretive framework can and must be identified and advanced in order to move the field forward. The participants are generating a ‘consensus road map’ leading to two workshop products: 1. an NSF white paper; and 2. an open-access, peer-reviewed manuscript. Through pre-workshop surveys, four workshop sessions, post-workshop collaboration, and publication, the team is summarizing current practices and recommending key methods for identifying and analyzing Symbiodiniaceae genetic diversity across three ‘umbrellas’: 1. communities, 2. populations, and 3. strains. The written products from this workshop are being distributed to the wider reef and conservation community by leveraging a separate mini-workshop previously developed for the 2022 International Coral Reef Symposium. Workshop participants are also highlighting new technologies and research priorities for the next decade that should help fill some of the remaining knowledge gaps.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14443", "attributes": { "award_id": "2122661", "title": "Doctoral Dissertation Research: Investigating the relationship between rural environments characterized by industrial agriculture and the timing of puberty", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "Bio Anthro DDRI" ], "program_reference_codes": [], "program_officials": [ { "id": 3025, "first_name": "Rebecca", "last_name": "Ferrell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 16495, "principal_investigator": { "id": 31069, "first_name": "Andrea", "last_name": "Wiley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31068, "first_name": "Mecca", "last_name": "Burris", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 221, "ror": "https://ror.org/01kg8sb98", "name": "Indiana University", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Puberty is known to be affected by nutritional status and psychosocial stress, but less is known about the role of rural environments and, specifically, exposure to chemicals that disrupt the endocrine system. This biocultural doctoral dissertation project explores how living in rural communities shaped by industrial agriculture impacts human growth and development. The investigators compare pubertal timing in agricultural communities that have high levels of endocrine-disrupting chemical exposure to non-agricultural communities in low-exposure areas. The research contributes new knowledge about variation in patterns of human reproduction, growth, and development. The findings can inform public health policy and public science outreach. The project includes the design of K-12 curricula on human biology and pesticides. Individuals from groups underrepresented in STEM include participants in the study as well as researchers who will be trained and mentored by the investigators.<br/><br/> Endocrine-disrupting chemicals like pesticides can disrupt hormones that regulate puberty, are energetically costly to detoxify, and increase chronic disease risk in adulthood. The investigators use silicone wristbands and gas chromatography to measure exposure to endocrine-disrupting pesticides through skin or respiration among girls in communities with high and low pesticide use. The researchers evaluate and control for the roles of nutritional status, assessed using anthropometry and 24-hour dietary recalls, and psychosocial stress, measured using a variety of validated instruments. Participant observation is used to understand the local sociocultural context and differences in lived experiences between girls in the agricultural and non-agricultural communities.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14444", "attributes": { "award_id": "2105424", "title": "Advancing archaeological synthesis through the digitization and interoperability of ceramic data", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "(SPRF-FR) SBE Postdoctoral Res" ], "program_reference_codes": [], "program_officials": [ { "id": 1351, "first_name": "Josie Welkom", "last_name": "Miranda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 148000, "principal_investigator": { "id": 31070, "first_name": "Kostalena", "last_name": "Michelaki", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31070, "first_name": "Kostalena", "last_name": "Michelaki", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2465, "ror": "", "name": "Torvinen, Andrea", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). This award was provided as part of NSF’s Social, Behavioral and Economic Sciences Postdoctoral Research Fellowships (SPRF) program. The goal of the SPRF program is to prepare promising, early career doctoral-level scientists for scientific careers in academia, industry or private sector, and government. SPRF awards involve two years of training under the sponsorship of established scientists and encourage Postdoctoral Fellows to perform independent research. NSF seeks to promote the participation of scientists from all segments of the scientific community, including those from underrepresented groups, in its research programs and activities; the postdoctoral period is considered to be an important level of professional development in attaining this goal. Each Postdoctoral Fellow must address important scientific questions that advance their respective disciplinary fields. Under the sponsorship of Dr. Kostalena Michelaki-Schwartz at Arizona State University and Dr. Andrea Berlin at Boston University, this postdoctoral fellowship award supports an early career scientist seeking to revolutionize the publication and accessibility of ceramic data. This research will both advance the theory and method of archaeology and create a common tool for the dissemination and interoperability of data related to ceramic manufacture from the advent of pottery through the Historic Period—the Pan-American Archaeological Ceramic Database (PAACD). This open-access, digital repository will provide the general public and archaeologists with a virtual resource of curated reference materials. By eliminating the complications of gaining access to physical collections and paywalled publications, or deciphering inconsistent terminology across languages, this project will increase the breadth, depth, and speed of research, and facilitate the inclusion of prehistoric material culture in educational resources. <br/><br/>Inspiration for the PAACD derives from the Fellow’s own research on the influence of social identification and collective action on the growth and decline of Epiclassic (600-900 CE) polities. Determining how closely these polities interacted and what forms their interactions took is currently hampered by a lack of regional-scale datasets. Therefore, building upon her previous research, the Fellow will complete an integrated database of ceramic types and attributes that will allow for synthetic research to be conducted. Thus, it offers an ideal foundation upon which to construct the PAACD. This work involves: (1) review and verify the existing attribute data on 238 types from 15 sites and one survey area and collect data from seven new collections; (2) conduct a technological analysis of a ceramic assemblage; and (3) integrate ceramic attribute data using the software and ontological framework of the Digital Archaeological Record (tDAR.org). The subsequent design and development of the PAACD will then involve consultation with a network of experts in ceramic technology and compositional methods that the Fellow has curated, as well as key stakeholders to ensure the functionality of the PAACD for all potential users. Several workshops will be organized to introduce the website to potential contributors and/or provide opportunities for mass data uploads to the site. The digital infrastructure of comparable and accessible data within the PAACD should be implemented in other regions of the world and replicated across other social science disciplines.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14445", "attributes": { "award_id": "2152622", "title": "NSF-NERC: PROcesses, drivers, Predictions: Modeling the response of Thwaites Glacier over the next Century using Ice/Ocean Coupled Models (PROPHET)", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "ANT Glaciology" ], "program_reference_codes": [], "program_officials": [ { "id": 29517, "first_name": "Kelly", "last_name": "Brunt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 1119530, "principal_investigator": { "id": 31071, "first_name": "Mathieu", "last_name": "Morlighem", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 386, "ror": "https://ror.org/049s0rh22", "name": "Dartmouth College", "address": "", "city": "", "state": "NH", "zip": "", "country": "United States", "approved": true }, "abstract": "This project contributes to the joint initiative launched by the U.S. National Science Foundation (NSF) and the U.K. Natural Environment Research Council (NERC) to substantially improve decadal and longer-term projections of ice loss and sea-level rise originating from Thwaites Glacier in West Antarctica. Thwaites Glacier has been accelerating and widening over the past three decades. How fast Thwaites will disintegrate or how quickly it will find a new stable state have become some of the most important questions of the future of the West Antarctic Ice Sheet and its contribution to sea-level rise over the next decades to centuries and beyond. This project will rely on three independent numerical models of ice flow, coupled to an ocean circulation model to (1) improve our understanding of the interactions between the ice and the underlying bedrock, (2) analyze how sensitive the glacier is to external changes, (3) assess the processes that may lead to a collapse of Thwaites, and, most importantly, (4) forecast future ice loss of Thwaites. By providing predictions based on a suite of coupled ice-ocean models, this project will also assess the uncertainty in model projections.<br/><br/>The project will use three independent ice-sheet models: Ice Sheet System Model, Ua, and STREAMICE, coupled to the ocean circulation model of the MIT General Circulation Model. The team will first focus on the representation of key physical processes of calving, ice damage, and basal slipperiness that have either not been included, or are poorly represented, in previous ice-flow modelling work. The team will then quantify the relative role of different proposed external drivers of change (e.g., ocean-induced ice-shelf thinning, loss of ice-shelf pinning points) and explore the stability regime of Thwaites Glacier with the aim of identifying internal thresholds separating stable and unstable grounding-line retreat. Using inverse methodology, the project will produce new physically consistent high-resolution (300-m) data sets on ice-thicknesses from available radar measurements. Furthermore, the team will generate new remote sensing data sets on ice velocities and rates of elevation change. These will be used to constrain and validate the numerical models, and will also be valuable stand-alone data sets. This process will allow the numerical models to be constrained more tightly by data than has previously been possible. The resultant more robust model predictions of near-future impact of Thwaites Glacier on global sea levels can inform policy-relevant decision-making.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14446", "attributes": { "award_id": "2147597", "title": "SG: Uncovering the contributions of albinism to the evolution of the Mexican cavefish", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Evolutionary Processes" ], "program_reference_codes": [], "program_officials": [ { "id": 599, "first_name": "Samuel", "last_name": "Scheiner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 200000, "principal_investigator": { "id": 31072, "first_name": "Johanna", "last_name": "Kowalko", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 341, "ror": "https://ror.org/012afjb06", "name": "Lehigh University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "When different organisms live in similar environments, the same traits can evolve in multiple, independent populations. One fascinating example of this is the reduction or loss of pigmentation in many different cave organisms. Despite how common this pattern is in wild populations, why cave organisms lose pigmentation is not well understood. This research will study the role of pigmentation loss in the evolution of Mexican cavefish. To do so, the project will examine the relationship between pigmentation, levels of neurotransmitters in the brain, and behavioral changes that may be beneficial to animals living underground. The broader impacts of this project take advantage of the cavefish system to increase access to science education. Teachers will work with the researchers to develop new units on cavefish biology to take back to their classrooms. Additionally, the researchers will create an undergraduate class that will allow students to get authentic research experiences. Finally, undergraduates and graduate students will be hired to participate in the research. <br/><br/>This project aims to understand the effects of pigmentation-reducing mutations on behavioral traits. Evidence suggests that mutations in the oca2 gene underlie albinism. Additionally, the mutations may impact levels of sleep-regulating neurotransmitters, raising the possibility that albinism is beneficial by reducing sleep time and promoting foraging in the nutrient-poor cave environment. To test this hypothesis, the research team will focus on A. mexicanus. Some advantages of this system include the existence of multiple, independently evolved cave populations and the ability to hybridize cave and surface fish. Specifically, this project has three aims. First, the researchers will measure levels of three specific neurotransmitters (dopamine, epinephrine, norepinephrine) in multiple populations of fish. Those populations include: 1) surface fish, 2) albino (oca2-mutant), 3) non-albino cavefish, and 4) oca2-mutant surface fish. Measuring neurotransmitter levels in the different fish populations will allow the researchers to determine if enhanced neurotransmitter levels are a general property of cavefish with reduced pigmentation. For the second aim, sleep will be measured in wild-type and oca2-mutant surface fish to determine the role of oca2 in a potentially fitness-related trait. Finally, the researchers will generate hybrids by crossing individuals from cave populations and surface populations. Sleep, pigmentation and neurotransmitter levels will be measured in these hybrid fish to determine the genetic relationship between these traits. Thus, this project will provide new insight into the role of albinism in a cave environment. Further, it will shed light on fundamental principles underlying evolution in response to colonization of a novel environment.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14448", "attributes": { "award_id": "2123284", "title": "The origins and evolution of ancient genomic structural variants in hominins", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Social, Behavioral, and Economic Sciences (SBE)", "(SPRF-FR) SBE Postdoctoral Res" ], "program_reference_codes": [], "program_officials": [ { "id": 3025, "first_name": "Rebecca", "last_name": "Ferrell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 306181, "principal_investigator": { "id": 31073, "first_name": "Omer", "last_name": "Gokcumen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 422, "ror": "", "name": "SUNY at Buffalo", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "This study explores hominin genetic variation, specifically focusing on previously understudied structural variants such as deletions and duplications of large DNA segments. The research advances knowledge about hominin adaptations and evolution from the distant past into the present, with anticipated outcomes emphasizing the shared genetic legacy of all humanity going back hundreds of thousands of years. The project supports the study of structural variants and anthropological genomics through training, methods development, and collaboration. Through planned workshops, scholars in the field can discuss the challenges and opportunities for swiftly and effectively disseminating diverse anthropological datasets and computational approaches. The project also serves as a framework to continue the training of a diverse undergraduate and graduate trainee community, as well as engage with the public to promote STEM training and anthropological genomics, especially through collaborations with the Genome, Environment, and Microbiome Center of Excellence at the University at Buffalo. <br/><br/>Genomic structural variants, which are deletions, duplications, inversions, and translocations of large genetic segments in mammalian genomes, have not been a major focus in anthropological genetics because of methodological challenges and the cost of studying these types of variants. However, as new technologies make studying these variants more feasible, new research suggests a broad and previously underappreciated effect of structural variants on human evolution. The study addresses hypotheses about balancing and positive selection as processes maintaining structural variants in the human lineage and generates opportunities for follow-up research to investigate the functional impact of structural variants, some of which may have biomedical relevance. The study has the potential to be transformative in our understanding of recent human evolution and the role of specific structural variants in shaping human biological variation.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14449", "attributes": { "award_id": "2120469", "title": "Collaborative Research: STEPP-NET: Steppe Parasite Networks", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Biological Sciences (BIO)", "Systematics & Biodiversity Sci" ], "program_reference_codes": [], "program_officials": [ { "id": 29475, "first_name": "Cathie", "last_name": "Aime", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 168569, "principal_investigator": { "id": 25726, "first_name": "Joseph", "last_name": "Cook", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 170, "ror": "https://ror.org/05fs6jp91", "name": "University of New Mexico", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "This project focuses on collecting and describing mammals and their tapeworm and flea parasites from the grasslands of Central Asia. These parasites are highly diverse and ecologically important groups, and many are sensitive indicators of ecosystem quality; further, the parasitic infections they cause can have major negative impacts on wildlife. They also can play an important role in transmitting diseases from wild to domesticated species, and also to humans. However, knowledge of the diversity of parasite species, their geographic distributions, and the precise hosts they occur on and in remains highly fragmentary for much of the world. Central Asian mammals and their associated parasites are particularly highly imperiled but also little studied. This project will collect new material and study how tapeworm and flea parasites from the region evolve in conjunction with their mammalian hosts; it will also consider how the hosts and parasites have responded to various ecological changes across the region. This work is extremely time-sensitive, with many Central Asian ecosystems on the cusp of major land use change as economies shift and major construction occurs in the region. Numerous specimens will be collected, and these will serve as a repository of parasite diversity useful for assessing how future global change influences the distribution of parasites and their hosts. This may ultimately improve public health outcomes. The work will also involve training the next generation of early-career STEM researchers for careers in biodiversity science. <br/><br/>The STEPP-NET project will rapidly advance discovery and description of species diversity, host associations, and community assembly, in two mammal-associated macroparasite clades - fleas and cestodes - across the vast grasslands of Central Asia. This region is a prototype for exploring host-parasite dynamics and spillover in response to human activity; historically, as a conduit for ancient Silk Road trade routes, and, currently, from intensifying land use changes and construction. STEPP-NET leverages existing museum specimens, new expeditionary collections in Mongolia and Kazakhstan, and genomic analyses of hosts and parasites to advance knowledge of species boundaries, environmental and host niche breadth, and the exploration of novel host interfaces by focal parasite clades in response to global change pressures. A key outcome of STEPP-NET will be an extended specimen network for Central Asia, in which mammal and parasite specimens are durably linked to derived data and immediately useful in global biodiversity studies and public health initiatives. The project also creates opportunities for STEM graduate and undergraduate students to participate across the spectrum of modern biodiversity science, from international fieldwork to specimen curation and digitization, genomics, and integrative taxonomy. It will build out this community of early-career STEM researchers even further by developing undergraduate and graduate educational modules that are implemented across our institutions and hosted online for broader biodiversity literacy.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14450", "attributes": { "award_id": "2137949", "title": "LEAPS-MPS: Singularities, Rigidity, and Trace Modules", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Mathematical and Physical Sciences (MPS)", "OFFICE OF MULTIDISCIPLINARY AC" ], "program_reference_codes": [], "program_officials": [ { "id": 2352, "first_name": "Stefaan De", "last_name": "Winter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 160175, "principal_investigator": { "id": 31074, "first_name": "Haydee", "last_name": "Lindo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1037, "ror": "https://ror.org/025ecfn45", "name": "Harvey Mudd College", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). The focus on this research is in commutative algebra with motivating questions, and applications, from representation theory and algebraic geometry. Commutative algebra concerns itself with the structure of solutions to systems of polynomial equations and so is connected to fundamental problems in the sciences and engineering. This project focuses on the study of fundamental algebraic objects known as modules and ideals over commutative rings. In particular, a trace module is the homomorphic image of one module in another and is a generalization of the image of the familiar trace map on a matrix. The trace module is an old construction enjoying renewed interest and has applications in commutative algebra and related fields. This project involves undergraduate students research with the aim of professional development, preparation for STEM careers, and broadening participation within the mathematical sciences.<br/><br/>This award supports the development of the modern theory of trace modules with applications to the representation theory of rational singularities, the annihilation of cohomology, and Ext-rigidity over commutative rings. In particular, this project is driven by questions under three broad categories related by the theory of trace modules over commutative rings. The first category explores the representation theory of Arf rings and other singularities. This includes making precise the relationship between the various notions of closure that coincide in the Arf setting with applications to the representation theory of higher-dimensional rings. The second goal is the development of the theory of trace modules over commutative rings. Finally, the project will study the phenomenon of Ext-rigidity over commutative rings and calculating the cohomology annihilator ideals when cohomology does not vanish.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14451", "attributes": { "award_id": "2122596", "title": "PFI-RP: Electrochemical Technologies for Pharmaceutical Synthesis via Nickel-Catalyzed Aryl-Alkyl Cross-Coupling", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Technology, Innovation and Partnerships (TIP)", "PFI-Partnrships for Innovation" ], "program_reference_codes": [], "program_officials": [ { "id": 27174, "first_name": "Debora", "last_name": "Rodrigues", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-15", "end_date": null, "award_amount": 550000, "principal_investigator": { "id": 31078, "first_name": "Cynthia", "last_name": "Hong", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31075, "first_name": "Cynthia M", "last_name": "Hong", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 31076, "first_name": "Daniel J", "last_name": "Weix", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 31077, "first_name": "Marcel", "last_name": "Schreier", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 263, "ror": "", "name": "University of Wisconsin-Madison", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "The broader impact/commercial potential of this Partnerships for Innovation – Research Partnerships (PFI-RP) project led by the University of Wisconsin-Madison and Merck & Co. Inc. lies in the development of a new environmentally benign electrochemical strategy for the synthesis of active pharmaceutical ingredients and their precursors. Electrochemical methods often bypass the requirement for costly, unsafe, toxic, and/or environmentally hazardous chemicals used in conventional thermal processes. The electrification of organic synthesis has potential to revolutionize pharmaceutical manufacturing. Reduction reactions involve the net transfer to electrons to a target molecule and they are commonly encountered in chemical manufacturing. Hydrogen gas, which may be produced from water using renewable energy, represents an ideal source of electrons for these reactions; However, hydrogen gas lacks the driving force needed to accomplish many important reduction reactions. Consequently, alternative reductants, such zinc, magnesium, and other metals are often used as a source of electrons. This project will develop electrochemical reactor technologies capable of using hydrogen as a source of electrons to accomplish reductive cross-coupling reactions that form carbon-carbon bonds commonly encountered in pharmaceuticals and other industrial chemicals.<br/><br/>The proposed project targets the development of electrochemical technologies that will enable nickel-catalyzed, cross-electrophile coupling reactions to be performed with hydrogen (H2) as the source of electrons. Several different H2-anode technologies will be evaluated and optimized for integration with cathodes that drive the nickel-catalyzed reductive coupling methods. This project will leverage established membrane-electrode assemblies and gas-diffusion hydrogen anode technologies used in commercial fuel cells. Technical challenges that must be addressed include the management of protons and water that migrate across the membrane of the electrochemical cell, both of which could interfere with the catalytic coupling reactions. These challenges will be overcome through the design and testing of various reactor configurations that offer different strategies to address these issues. By combining the expertise of synthetic chemists, engineers and leading practitioners from the pharmaceutical industry, this project will elevate the technology-readiness level of electrochemical carbon-carbon bond forming reactions using H2 as an electron source.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1424, "count": 14236 } } }