Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1391&sort=-approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=-approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1392&sort=-approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1390&sort=-approved" }, "data": [ { "type": "Grant", "id": "12391", "attributes": { "award_id": "1R43DA059516-01", "title": "A wearable device for continuous monitoring of methadone", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 25684, "first_name": "Yordan Valtchov", "last_name": "Kostov", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2024-03-31", "award_amount": 319754, "principal_investigator": { "id": 28332, "first_name": "Farshad", "last_name": "Tehrani", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2092, "ror": "", "name": "ACTIOX LLC", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Opioid overdose is a significant public health problem that has been escalating in recent years. Based on the statistics from the Centers for Disease Control and Prevention (CDC), the number of overdose-related deaths surpassed 100,000 from April 2020 to April 2021. This is a significant increase in overdose cases related to natural and semi-synthetic opioids, synthetic opioids, and psychostimulants. Alarmingly, in the one-year period leading up to April 2021, fentanyl was the top cause of death for adults between 18 and 45 years old, surpassing fatalities caused by car accidents, suicide, COVID, and cancer. Methadone is a well-established medication that has been used for decades to treat opioid use disorder (OUD). However, there is currently no continuous monitoring device that can provide real-time information on methadone levels in the body. This gap in monitoring can result in patients not receiving optimal doses of methadone, leading to relapse or overdose. To address this problem, we propose a wearable device for continuous monitoring of methadone. Our proposed device is a minimally invasive microneedle technology that can be worn on the skin. This device will continuously monitor methadone levels in the body, providing real-time feedback to patients and healthcare professionals. The device is small, discreet, and easy to use, making it ideal for use in various settings. The proposed SBIR project aims to leverage our innovative microneedle technology to develop a wearable device that can continuously monitor therapeutic levels of methadone in the interstitial fluid for a week. In order to achieve this, the team will perform systematic optimization studies on the surface architecture of the sensor to enable highly sensitive, stable, and selective methadone sensing performance. Aim 1 constitutes in-vitro feasibility studies to find the best chemical modification strategy with high sensitivity. Aim 2 will involve extending the stability of the sensor to one week of continuous operation. Aim 3 will assess the selectivity, reproducibility, and shelf life of the developed MN-based methadone sensors in serum samples and involves further developments in the electronics and the accompanying app of the device. Upon successful completion of Phase I, Phase II will focus on demonstrating the utility and establishing reliability of the sensor via extensive clinical studies in both animals and in human subjects. The device will not only provide accurate and personalized dosing of methadone but also help in mitigating OUD by alerting patients and healthcare professionals when levels of methadone fall below or rise above therapeutic levels. This will enable healthcare providers to adjust the methadone dose in real-time, ensuring that patients receive optimal dosages to prevent relapse and overdose. The proposed wearable device for continuous monitoring of methadone is a crucial innovation that will help to address the problem of opioid overdose. The device will provide accurate and personalized dosing of methadone, help to mitigate OUD, and can be used among different populations. Our proposed device has the potential to improve the quality of life of patients, reduce healthcare costs, and ultimately save lives.", "keywords": [ "Address", "Adult", "Affect", "Alcohols", "Animals", "Architecture", "Biochemical", "Biological Markers", "Caregivers", "Caring", "Cause of Death", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Chemicals", "Chemistry", "Clinical Research", "Communities", "Coupled", "Custom", "Detection", "Development", "Devices", "Dose", "Electrodes", "Electron Transport", "Electronics", "Engineering", "Ensure", "Epidemic", "FDA approved", "Family", "Feasibility Studies", "Feedback", "Fentanyl", "Foreign Bodies", "Glucose", "Goals", "Health Care Costs", "Health Personnel", "Health Professional", "Heroin", "In Vitro", "Individual", "Intercellular Fluid", "Levodopa", "Life", "Malignant Neoplasms", "Marketing", "Measurement", "Measures", "Medical", "Membrane", "Methadone", "Methods", "Modification", "Monitor", "Morphine", "Motion", "Nanostructures", "Needles", "Noise", "Noscapine", "Opiate Addiction", "Opioid", "Overdose", "Patients", "Performance", "Pharmaceutical Preparations", "Phase", "Physiological", "Physiology", "Polymers", "Population", "Porosity", "Privatization", "Propofol", "Public Health", "Quality of life", "Reagent", "Relapse", "Reproducibility", "Risk Reduction", "Sampling", "Secure", "Serum", "Signal Transduction", "Skin", "Small Business Innovation Research Grant", "Societies", "Specificity", "Sterilization", "Suicide", "Surface", "System", "Technology", "Temperature", "Testing", "Therapeutic", "Time", "Visualization", "Withdrawal Symptom", "appropriate dose", "automobile accident", "biomaterial compatibility", "cloud platform", "coronavirus disease", "cytotoxicity", "design", "dosage", "drug craving", "falls", "human subject", "improved", "in vivo", "individual patient", "innovation", "innovative technologies", "inter-individual variation", "invention", "meter", "methadone treatment", "minimally invasive", "mobile application", "monitoring device", "nanomolar", "operation", "opioid overdose", "opioid use disorder", "opioid withdrawal", "overdose risk", "oxidation", "precision medicine", "prevent", "psychostimulant", "relapse prevention", "response", "sensor", "statistics", "synthetic opioid", "wearable device", "wearable sensor technology", "wireless", "wireless transmission" ], "approved": true } }, { "type": "Grant", "id": "12392", "attributes": { "award_id": "1R01MD019042-01", "title": "ACCTiVATE: Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 23654, "first_name": "YEWANDE A", "last_name": "Oladeinde", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-25", "end_date": "2028-05-31", "award_amount": 478441, "principal_investigator": { "id": 28333, "first_name": "Delphine", "last_name": "Tuot", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 768, "ror": "https://ror.org/043mz5j54", "name": "University of California, San Francisco", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Chronic diseases such as hypertension, diabetes and chronic kidney disease cause significant mortality, with stark inequities impacting racially and ethnically minoritized populations. The COVID-19 pandemic prompted a rapid shift in chronic disease management to telehealth-based care, including patient portals, telemedicine video visits, and remote patient monitoring. However, there are substantial racial/ethnic and socioeconomic disparities in health IT access for chronic disease management in the United States. This is due to patient-level barriers such as inequitable device and internet access and lower digital literacy, as well as clinic-level barriers such as inadequate support to access digital technologies and skills, inequitable offering of health IT, and a lack of equity-focused, stratified telehealth data. Increasing telehealth use among minority populations has the potential to lessen disparities in chronic disease health outcomes. We propose a 2x2 randomized controlled trial entitled “Achieving Chronic Care equiTy by leVerAging the Telehealth Ecosystem” (ACCTiVATE), in which we will examine the impact of a multi-level intervention that tackles patient-level and clinic-level barriers to increase the equitable use of health IT for chronic disease management. The patient-level intervention combines the role of digital health navigator and chronic disease health coach to facilitate access to devices and broadband, offer digital skills training, and provide chronic disease health coaching focused on telehealth modalities. The clinic-level intervention includes Practice Facilitation with a learning collaborative, clinic-specific Community Advisory Boards, and electronic “Telehealth Equity Dashboards” that display telehealth utilization stratified by race/ethnicity. We will randomize 600 English- and Spanish-speaking adults with uncontrolled hypertension across 10 federally qualified health centers to digital coaching versus usual care. The 10 health centers will be randomized to Practice Facilitation versus usual care. In Aim 1, we will assess the impact of the multi-level intervention (coaching combined with practice facilitation, and each arm alone) on systolic blood pressure (primary outcome), hemoglobin A1c, and microalbuminuria overall, and among Black and Latinx patients. In Aim 2, we will assess impacts on process measures of telehealth disease management (digital literacy, medication adherence, engagement with health IT). In Aim 3, we will conduct a mixed methods evaluation of implementation by applying the RE-AIM framework to identify key features needed for successful adoption and dissemination by healthcare networks. A multidisciplinary Stakeholder Advisory Board will advise on all Aims. The proposed intervention recognizes the multilevel determinants that have perpetuated the digital divide, worsening chronic disease care during the pandemic. The impact of this intervention will result in an efficient, user-centered multilevel intervention for improved telehealth engagement, medication adherence, and digital literacy, which are all key drivers of improved chronic disease outcomes.", "keywords": [ "Address", "Adoption", "Adult", "Affect", "American", "Appointment", "Asian", "Black Populations", "Black race", "Blood Pressure", "COVID-19 pandemic", "Cardiovascular Diseases", "Cardiovascular system", "Caring", "Cessation of life", "Child Care", "Chronic", "Chronic Care", "Chronic Disease", "Chronic Kidney Failure", "Clinic", "Clinical", "Communication", "Communities", "Community Health", "Community Health Aides", "Competence", "Data", "Development", "Devices", "Diabetes Mellitus", "Disease Management", "Disease Outcome", "Disparity", "Ecosystem", "Effectiveness", "Electronics", "Equity", "Ethnic Origin", "Evaluation", "Face", "Federally Qualified Health Center", "Glycosylated Hemoglobin", "Glycosylated hemoglobin A", "Goals", "Health", "Health Status", "Health Technology", "Healthcare", "Hypertension", "Individual", "Inequity", "Internet", "Intervention", "Interview", "Latinx", "Latinx population", "Learning", "Linguistics", "Low income", "Methods", "Microalbuminuria", "Minority Groups", "Modality", "Morbidity - disease rate", "Outcome", "Patient Preferences", "Patients", "Persons", "Process", "Process Measure", "Provider", "Public Health", "Race", "Randomized", "Randomized Controlled Trials", "Reach Effectiveness Adoption Implementation and Maintenance", "Reduce health disparities", "Risk Factors", "Role", "San Francisco", "Self Efficacy", "Self Management", "Stroke", "System", "Technology", "Telemedicine", "Telephone", "Training Support", "Transportation", "United States", "Visit", "Voice", "Work", "arm", "cardiovascular health", "cardiovascular risk factor", "care delivery", "clinical care", "dashboard", "digital", "digital health", "digital technology", "ethnic disparity", "ethnic diversity", "ethnic minority", "ethnic minority population", "experience", "health care delivery", "health care disparity", "health data", "health disparity", "health equity", "hypertension control", "implementation determinants", "implementation evaluation", "implementation framework", "implementation intervention", "implementation outcomes", "implementation strategy", "improved", "interest", "literacy", "low socioeconomic status", "marginalization", "medication compliance", "minority patient", "mortality", "multidisciplinary", "operation", "outcome disparities", "pandemic disease", "patient engagement", "patient level intervention", "patient oriented", "patient portal", "pat" ], "approved": true } }, { "type": "Grant", "id": "12393", "attributes": { "award_id": "1R44HD114323-01", "title": "A Translational Research Approach to Healthy Technology Usage in Language-Minority Families with Young Children", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 28334, "first_name": "Kathy M", "last_name": "Mann Koepke", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2024-08-31", "award_amount": 274996, "principal_investigator": { "id": 28335, "first_name": "Rosa Guzman", "last_name": "Turco", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2093, "ror": "", "name": "TRANSCENDENT INTERNATIONAL, LLC", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Technology use among young children in the U.S. has become increasingly prevalent over the past decade, and the transition to online learning during the COVID-19 pandemic has renewed concerns among parents and educators about screen time. Recommendations for choosing high-quality apps and setting boundaries around device use are often conveyed through position statements, white papers, and blog posts, but the information is rarely presented in an engaging, family-friendly manner that can be readily adopted and sustained in young children’s everyday routines. As a matter of health equity, this challenge is felt even more acutely among language-minority households, who additionally face language barriers when attempting to access relevant resources. This project delivers an interactive, bilingual, hybrid virtual-and-physical world approach to address these translational gaps. It presents recommendations from the academic and medical spheres through bilingual storytelling and a suite of interactive, co-play activities in an online virtual world, then transitions the gameplay to caretaker-child interactions in the physical world, empowering users to first practice healthy technology through interactive online games and then implement those rehearsed practices in their day-to-day lives. The effectiveness of the online platform and interactive content will be evaluated through a randomized controlled study. Improvements in knowledge, attitudes, and confidence related to healthy technology use will be assessed among children and their caretakers. The platform will also be evaluated for its ability to facilitate bilingual interactions between child and caretaker that support learning and language development. Overall, our product will serve not only as a means to inform families of best technology use practices, but as a catalyst to broaden and reimagine joint play with digital devices especially among linguistic minority families.", "keywords": [ "6 year old", "Academy", "Acute", "Address", "Adopted", "Advocacy", "Advocate", "Age", "American", "Area", "Articulation", "Attitude", "Awareness", "Behavior", "Behavioral", "Books", "COVID-19 pandemic", "Caregiver support", "Caregivers", "Child", "Child Rearing", "Code", "Communication", "Computer software", "Consumption", "Data", "Decision Making", "Development", "Devices", "E-learning", "Education", "Educational process of instructing", "Effectiveness", "Emotional", "Ensure", "Environment", "Evaluation", "Face", "Family", "Feedback", "Flowers", "Fostering", "Friends", "Generations", "Goals", "Habits", "Health education", "Home environment", "Household", "Hybrids", "Informatics", "Intervention", "Interview", "Joints", "Knowledge", "Language", "Language Development", "Learning", "Libraries", "Linguistics", "Literature", "Measures", "Medical", "Methodology", "Minority", "Modeling", "National Institute of Child Health and Human Development", "Neurocognitive", "Outcome", "Pamphlets", "Paper", "Parent-Child Relations", "Parents", "Participant", "Pediatrics", "Phase", "Play", "Positioning Attribute", "Process", "Proliferating", "Provider", "Questionnaires", "Recommendation", "Research", "Research Priority", "Resources", "Respondent", "Role", "Scheme", "Series", "Small Business Innovation Research Grant", "Social Interaction", "Strategic Planning", "Stream", "Surveys", "Technology", "Testing", "Translating", "Translational Research", "Video Recording", "age group", "bilingualism", "catalyst", "design", "digital", "digital media", "digital technology", "electronic book", "empowerment", "evidence base", "health care disparity", "health equity", "improved", "information gathering", "interest", "meetings", "prototype", "randomized controlled study", "skills", "social", "tv watching", "underserved community", "usability", "verbal", "virtual", "virtual world", "web platform" ], "approved": true } }, { "type": "Grant", "id": "12394", "attributes": { "award_id": "1C06OD036038-01", "title": "Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-08", "end_date": "2027-04-30", "award_amount": 8000000, "principal_investigator": { "id": 23354, "first_name": "JOANNE", "last_name": "TURNER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1083, "ror": "https://ror.org/00wbskb04", "name": "Texas Biomedical Research Institute", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1083, "ror": "https://ror.org/00wbskb04", "name": "Texas Biomedical Research Institute", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) rhesus macaque colony of Indian origin (Ind RM), supported by the NIH SPF rhesus breeding program (U42OD010442), and a smaller SPF P51 supported colony. We currently house ~1000 rhesus macaques, of which the U42 colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions. However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF Ind RM. This has severely impacted our ability to support the national and international research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc. The NIH has recognized this need for expansion of SPF rhesus production and strongly recommends increasing Ind RM breeding capacity. The SNPRC is well positioned to expand its SPF Ind RM production as a center located in a climate hospitable to largely outdoor housing, at an institution with capacity for expansion. Our host institution, Texas Biomed, raised funds and is currently building new NHP facilities which will house ~600 NHPs. Texas Biomed/SNPRC has also been funded by the NIH/ORIP to expand our production capacity by 30% over our existing capacity via other mechanisms. Finally, through Texas Biomed support, we have procured ~150 conventional founder/breeder Ind RM. This founder colony has increased the number of breeding pairs the SNPRC macaque colony management team can generate, and it is expected that in the upcoming birthing season, ~200 RM live births will occur, double that of each of the last several years. As such the SNPRC Ind RM population can increase to 1500+ in the next five years. Funded partially by this C06, we seek to construct an additional animal housing/breeding facility adjacent the two new holding/breeding facilities currently under construction, as part of the overall $45M long term Animal Care Complex project. This will further allow us to house, breed and maintain an additional supply of ~300 Ind RM for AIDS/emerging infectious diseases research.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Animal Housing", "Animals", "Area", "Breeding", "COVID-19", "Climate", "Communicable Diseases", "Complex", "Emerging Communicable Diseases", "Fund Raising", "Funding", "HIV/AIDS", "Housing", "Infectious Diseases Research", "Institution", "International", "Live Birth", "Macaca", "Macaca mulatta", "Malaria", "Mission", "Population", "Positioning Attribute", "Primates", "Production", "Recommendation", "Research", "Research Personnel", "Resources", "Rhesus", "Sales", "Texas", "United States National Institutes of Health", "animal care", "co-infection", "germ free condition", "nonhuman primate", "programs", "season of birth" ], "approved": true } }, { "type": "Grant", "id": "12395", "attributes": { "award_id": "1R01HD115249-01", "title": "Using Immersive Virtual Reality and Media Literacy to Enhance Adolescents' Coping Skills in the Face of Traumatic Online Experiences", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 7137, "first_name": "LAYLA E", "last_name": "ESPOSITO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-18", "end_date": "2028-05-31", "award_amount": 1073590, "principal_investigator": { "id": 28336, "first_name": "Brendesha Marie", "last_name": "Tynes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Race-related traumatic online experiences have become daily stressors in the lives of adolescents of color. Black adolescents for example, have an average of 5.2 incidents of racial discrimination per day, with those occurring online as most frequent. Examples include witnessing calls for genocide of people of color, mock lynchings, and having your intelligence questioned because of your race. Media literacy education and school- based mental health interventions, where one might expect adolescents to receive preparation for these experiences, are either inadequately preparing youth, or exclude a discussion of the issues altogether. Media literacy programs, for example, only cover race through a cursory lens. Other school-based efforts, such as mental health interventions, may be stigmatized or stigmatizing, limiting their effectiveness. There is a dire need for training in how to critique and cope with race-related messages in a safe, and engaging environment, free of stigma. We propose an unusually innovative and immersive virtual reality (VR) media literacy and coping skills prevention intervention. Drawing on media literacy as health promotion framework, best practices in immersive VR for psychoeducation, and culturally-responsive computing theory, we will design and develop the intervention, and evaluate its efficacy with a pilot randomized controlled trial. The potential impact is far reaching, including curbing the alarming, rising rates of depression, anxiety, and other mental health symptoms among Black and Latinx communities since the beginning of the COVID-19 pandemic. The project is perfectly aligned with the Transformative Research Award, in that findings have the potential to fundamentally reshape how we educate young people to critique, counter, and cope with online experiences. Given that virtuality is believed to be the wave of the future, with some arguing for a coming “metaverse,” where much of our lives will be through VR, this project will provide a model for ensuring that psychoeducation, delivered by an immersive VR intervention, can meet the unique needs of adolescents of color. In addition, we hope to usher in a world where every internet user is educated about the mental health impacts of online social interactions and experiences, as they receive expanded access. At the conclusion of this project, we will produce an immersive VR intervention that has the potential to reduce disparities in access to mental health services in underserved communities, leading to better mental health equity and outcomes among Black and Latinx adolescents. This transformative experience will help Black and Latinx young people become more efficacious with respect to racial coping. It will also provide a toolkit for students to imagine and create a digital world where they are able to thrive in the face of traumatic online experiences.", "keywords": [ "19 year old", "Address", "Adolescent", "Anxiety", "Automobile Driving", "Award", "Black race", "Buffers", "COVID-19 pandemic", "Child", "Color", "Communities", "Coping Skills", "Coupling", "Critiques", "Development", "Discrimination", "Distance Learning", "Education", "Effectiveness", "Ensure", "Environment", "Evaluation", "Exclusion", "Feeling suicidal", "Future", "Genocides", "Health Promotion", "Image", "Intelligence", "Internet", "Intervention", "Latinx", "Learning", "Literacy Programs", "Mental Depression", "Mental Health", "Mental Health Services", "Modeling", "Outcome", "Participant", "Persons", "Post-Traumatic Stress Disorders", "Preparation", "Prevention", "Published Comment", "Race", "Randomized Controlled Trials", "Reporting", "Research", "Sampling", "Schools", "Self Efficacy", "Shapes", "Social Interaction", "Stigmatization", "Students", "Symptoms", "Telephone", "Therapeutic", "Training", "Youth", "access disparities", "coping", "depressive symptoms", "design", "digital", "digital media", "disinformation", "disparity reduction", "experience", "health equity", "innovation", "insight", "laptop", "lens", "literacy", "people of color", "preventive intervention", "psychoeducation", "psychoeducational", "racial discrimination", "racism", "rumination", "skills", "social stigma", "stressor", "substance use", "teacher", "theories", "underserved community", "virtual", "virtual reality", "virtual reality environment", "virtual reality intervention" ], "approved": true } }, { "type": "Grant", "id": "12396", "attributes": { "award_id": "1R21AA031101-01", "title": "Neuroimmune mechanisms of adult chronic ethanol consumption", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 22550, "first_name": "Changhai", "last_name": "Cui", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-12", "end_date": "2025-08-31", "award_amount": 404508, "principal_investigator": { "id": 28337, "first_name": "Florence Prabha", "last_name": "Varodayan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 890, "ror": "", "name": "STATE UNIVERSITY OF NY,BINGHAMTON", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Excessive alcohol consumption has risen during the ongoing COVID 19 pandemic, and there is an urgent need to improve treatment options. Individuals with alcohol use disorder (AUD) struggle with inhibitory control, decision making and emotional processing, and these cognitive symptoms reduce treatment adherence, worsen clinical outcomes, and promote relapse. The neuroimmune system is a key player in the pathophysiology of AUD, and targeting this modulatory system is less likely to produce unwanted side effects compared to directly targeting neurotransmitter dysfunction. Of particular interest, the cytokine interleukin-1β (IL-1β) is implicated in the cognitive symptoms of AUD. There are strong genetic associations among the IL-1 system, AUD and cognitive decline, and individuals with AUD have elevated postmortem brain and peripheral levels of IL-1β. The IL-1 signaling complex typically contains AcP, which generates neuroinflammatory responses. However, neurons also express AcPb, a second accessory protein that is neuroprotective and curbs the canonical AcP neuroinflammatory response. Aging increases the ratio of AcP to AcPb, leading to a stronger neuroinflammatory response, impaired synaptic plasticity and spatial memory deficits. Since individuals with AUD show signs of premature cortical aging, we hypothesize that chronic ethanol exposure produces a similar proinflammatory bias in IL-1β/AcP signaling within the medial prefrontal cortex (mPFC), thereby contributing to deficits in cognitive function. Therefore, here we will examine IL-1β synaptic regulation in early withdrawal and protracted abstinence in male and female mice. We will also test the hypothesis that early withdrawal and protracted abstinence lead to AcP-mediated cognitive impairment. Thus, the overarching goal of this proposal is to determine the neuroimmune mechanisms by which chronic ethanol produces long-lasting changes in mPFC function. The proposed studies will (i) fill critical gaps in our knowledge regarding IL-1β/neuroimmune regulation of basal mPFC function, (ii) provide essential information about how the consequences of chronic ethanol on the IL-1/neuroimmune system manifest in males and females, and (iii) potentially identify AcP as a novel pharmaceutical target for treating the cognitive symptoms of AUD. These studies will have important implications for our understanding of how persistent neuroinflammation can lead to the pathophysiology of AUD, and will promote the development of a new class of pharmacotherapeutics.", "keywords": [ "Abstinence", "Adult", "Aging", "Alcohols", "Autopsy", "Binding", "Brain", "COVID-19 pandemic", "Chronic", "Clinical", "Complex", "Data", "Decision Making", "Development", "Drug usage", "Emotional", "Ethanol", "Female", "Functional disorder", "Glutamates", "Goals", "Heavy Drinking", "Hippocampus", "Impaired cognition", "Impairment", "Individual", "Inflammatory", "Infusion procedures", "Injections", "Interleukin-1", "Interleukin-1 Receptors", "Interleukin-1 beta", "Knowledge", "Lead", "Learning", "MAP Kinase Gene", "Medial", "Mediating", "Memory impairment", "Messenger RNA", "Mus", "Neurobehavioral Manifestations", "Neuroimmune", "Neuroimmune system", "Neuroimmunomodulation", "Neurons", "Neurotransmitters", "Outcome", "PIK3CG gene", "Pathway interactions", "Peripheral", "Pharmacologic Substance", "Prefrontal Cortex", "Proteins", "Regulation", "Relapse", "Role", "Sex Differences", "Signal Transduction", "Synapses", "Synaptic plasticity", "System", "Testing", "Withdrawal", "aged", "alcohol exposure", "alcohol use disorder", "antagonist", "chronic alcohol ingestion", "cognitive function", "cytokine", "gamma-Aminobutyric Acid", "genetic association", "improved", "interest", "male", "neuroinflammation", "neuroprotection", "novel", "p38 Mitogen Activated Protein Kinase", "pharmacologic", "premature", "prevent", "receptor", "receptor expression", "recruit", "reduce symptoms", "response", "sex", "side effect", "spatial memory", "treatment adherence" ], "approved": true } }, { "type": "Grant", "id": "12397", "attributes": { "award_id": "1U18HS029947-01", "title": "Comprehensive Long COVID Care for Underserved Communities: Innovative Delivery and Dissemination Models (Comunidad)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 28197, "first_name": "Leeann", "last_name": "Comfort", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 999149, "principal_investigator": { "id": 28338, "first_name": "Lisa", "last_name": "Kilpela", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28339, "first_name": "JOEL", "last_name": "TSEVAT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28340, "first_name": "Monica", "last_name": "Verduzco-Gutierrez", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 748, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCIENCE CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Long COVID specialty clinics, some with a multidisciplinary staff, have emerged in various locations, but comprehensive, coordinated care is not readily accessible to many with Long COVID. The Post-COVID-19 Recovery Clinic at UT Health San Antonio serves not only San Antonio, the seventh largest city in the US, but also the largely rural and Hispanic/Latino population of South Texas, a population beset by health disparities. And yet, a major challenge in our current model is the 5-month wait for a new patient appointment and the additional delay to see medical specialists and mental health providers. Further, given our patient population’s many adverse social determinants of health and limited access to care, ready availability of social workers is critical but currently limited. Within our patients’ local communities, there is also a shortage of primary care providers available and knowledgeable about diagnosing, evaluating, and managing people with Long COVID. Moreover, there is a lack of awareness about Long COVID and rife misinformation and disinformation among community members in our vast South Texas catchment area. To improve and expand Long COVID care in San Antonio and South Texas, and to test new, sustainable models of care, we propose to conduct the Comprehensive Long COVID Care for Underserved Communities: Innovative Delivery and Dissemination Models (COMUNIDAD) project, a 5-year program with 3 aims: Aim 1: To expand holistic, multidisciplinary care at UT Health San Antonio. Together with patient and community representatives, we will develop evidence-based, symptom-specific best practices for evaluation, treatment, and self-care. Clinical services and, as appropriate, research study referrals, will be coordinated by a full-time nurse clinical coordinator and care will be provided by a multidisciplinary team. To expand the workforce, we will offer clinical rotations for health professional trainees. Aim 2: To collaborate with community providers on best practices for basic Long COVID evaluation and management. Utilizing Project ECHO and other telementoring modalities, we will disseminate information among clinicians in South Texas rural clinics on conducting a 15-minute, low-tech evaluation of patients presenting with Long COVID symptoms. Care can then be managed locally or referred to the UT Health Long COVID clinic. Aim 3: To partner with the community to disseminate up-to-date information about Long COVID among the largely Hispanic/Latino, rural South Texas communities. Based on community preferences, we will utilize community health workers, mobile apps, social media platforms, and other communication avenues in English and Spanish to increase health literacy and teach the community about Long COVID and accessing care. We anticipate participating actively in the AHRQ learning community to incorporate up-to-date evidence- based care and share information on models of care with other Long COVID centers. If adopted nationally, models such as COMUNIDAD will greatly improve care for persons with Long COVID.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12398", "attributes": { "award_id": "1C06OD035570-01", "title": "Expansion of Macaque Breeding runs at the New Iberia Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-12", "end_date": "2027-08-31", "award_amount": 3999070, "principal_investigator": { "id": 24751, "first_name": "Francois J", "last_name": "Villinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 2094, "ror": "", "name": "RAGIN' CAJUN FACILITIES, INC.", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "University of Louisiana at Lafayette C06 Expansion of Macaque Breeding capacity at the New Iberia Research Center Abstract: As part of its expansion of its HIV/AIDS research program, the New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette (UL Lafayette) proposes to add macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation for an added capacity of 1600 macaque breeders + offsprings via the Ragin Cajun Facilities, Inc. Foundation. NIRC has experienced exponential growth in the past 6 years, playing a critical role in the SARS-CoV2 pandemic while maintaining a vigorous HIV research program in support of collaborators whose laboratories were shut down. As part of this growth, NIRC has expanded its nonhuman primate (NHP) breeding and cohorts, from 6,400 to >10,000 NHPs, now the largest primate center in the US. The recent suspension of primate export from China and the limitations on NHP transport in cargo, have created an acute and monumental shortage of research NHPs, markedly amplified by their heavy use to test COVID vaccines and therapies. This has doubled and tripled animal acquisition costs, which will largely limit primate based research for academic investigators for the next decade and beyond. In efforts to palliate this gap in supply, NIRC has, and continues to expand NHP breeding and research housing, in addition to ongoing renovation of laboratory space and the construction of a BSL-3 facility regrouping rodents, NHPs and labs. The ongoing increase in breeder and research space has been the conversion of space originally used for chimpanzees into monkey social and research (quad cages) housing, and the construction of 2 new multi-run housing buildings supported by a C06 award obtained in 2021 (projected completion and occupancy date in late 2023). NIRC currently has ~1400 2-4 year old rhesus macaques future breeders slated to occupy this space, and given an annual live birth rate of >1000 rhesus macaques, NIRC has to expand such housing option further, via the construction of 2 additional identical units via this proposal. Of note, there will be space for 3 more such units for future expansion in the same area. This type of building has been specifically designed and extensively tested for macaque housing/breeding at a facility in Texas, attesting to the adequacy, ease of maintenance and longevity of such construction in southern climates. Each building unit will comprise 20 indoor/outdoor runs able to accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. Many of these programs are experiencing delays due to NHP and space shortages, which are holding back the scientific expansion of NIRC and the support of HIV/AIDS NIH funded research.", "keywords": [ "4 year old", "Acute", "Air", "Animals", "Area", "Award", "Back", "Birth Rate", "Breeding", "COVID test", "COVID-19 pandemic", "China", "Circulation", "Climate", "Colorectal", "Electricity", "Foundations", "Funding", "Future", "Grouping", "Growth", "HIV", "HIV/AIDS", "Heating", "Housing", "Laboratories", "Live Birth", "Longevity", "Louisiana", "Macaca", "Macaca mulatta", "Maintenance", "Monkeys", "Mucous Membrane", "National Institute of Allergy and Infectious Disease", "Pan Genus", "Pathogenesis", "Play", "Primates", "Research", "Research Personnel", "Rodent", "Role", "Running", "Signal Transduction", "Site", "Suspensions", "Testing", "Texas", "Therapeutic", "United States National Institutes of Health", "Universities", "Vaccines", "Vagina", "Viral", "Water", "biosafety level 3 facility", "cohort", "cost", "design", "experience", "imaging capabilities", "microbicide", "nonhuman primate", "offspring", "palliate", "prevent", "programs", "social" ], "approved": true } }, { "type": "Grant", "id": "12399", "attributes": { "award_id": "1U01GH002402-01", "title": "Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC-IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 400000, "principal_investigator": { "id": 28341, "first_name": "Supaporn", "last_name": "Wacharapluesadee", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2095, "ror": "https://ror.org/028wp3y58", "name": "Chulalongkorn University", "address": "", "city": "", "state": "", "zip": "", "country": "THAILAND", "approved": true }, "abstract": "Public health threats including emerging infectious diseases (EIDs) have highlighted the need for strengthening surveillance and laboratory systems for faster and smarter outbreak response. The Thai Department of Diseases Control (DDC), the Department of Medical Sciences (DMSc), Ministry of Public Health have collaboratively worked with Chulalongkorn University (CU) and the Thai Red Cross Society (TRC) on HIV research and other emerging endemic infectious disease surveillance, prevention, and control. This proposal will launch the “Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC- IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention”, a collaborative nested network among infectious disease control researchers from DDC, DMSc, CU and TRC, as well as EID experts in the USA and France. The iPHAC-IDC will establish an integrated and sustainable network to prepare for future disease outbreaks in Thailand. We will conduct research to 1) Develop and implement the NextGen Public Health Surveillance Approaches by using the PCR, next-generation sequencing, and multiplex serology assays to identify novel viruses, characterize the genomes of new-rare viral strains of endemic diseases, EIDs, and AMR. These genomic data will be integrated with clinical and epidemiologic data to create a pathogen genomic surveillance platform. In addition, genomic-mathematic models will be developed and embedded in the platform for real-time analysis. One Health surveillance approaches in the environment, including wastewater and air, and SARS-CoV-2 reverse zoonoses in wildlife will be pursued. 2) Develop and implement the GLLP curriculum at the School of Global Health by creating a GLLP curriculum at the Faculty of Medicine, Chulalongkorn University, in two pattern courses; A mandatory course in the One Health Branch of the Medical Sciences program and an elective course for other graduate students and a lifelong learning platform for all participants with an option to keep the credits for further claims after enrollment to CU. 3) Develop a youth-focused HIV prevention service model in the government hospital network by establishing youth-focused clinics that provide comprehensive HIV education and prevention with pre-exposure prophylaxis leveraging social network strategies, and improving gonorrhea antimicrobial genomics resistance surveillance. This research will advance our understanding of the risk of EIDs and endemic diseases and strengthen in- country public health research capacity and promote laboratory workforce development for pandemic preparedness and adolescent HIV prevention.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12400", "attributes": { "award_id": "1R50CA278859-01", "title": "Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 28342, "first_name": "ONN WOLF WOLF", "last_name": "Lindwasser", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-19", "end_date": "2028-08-31", "award_amount": 160532, "principal_investigator": { "id": 28343, "first_name": "Nina Delaney", "last_name": "Wagner-Johnston", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Both the impacts from COVID-19 as well as the increasing complexities of clinical trials, with a particular emphasis on precision medicine trials, have led to a recent decline in enrollments. This proposal identifies strategies to address the challenges of enhancing clinical trial enrollments in the hematologic malignancies (HM) program at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The two-pronged approach tackles system barriers and patient barriers. A clinical trial toolkit will be developed to address systems barriers with the goal of minimizing inefficiencies within our research operations program, increasing enrollment, and ultimately creating a clinical trial portfolio that best serves our patients. Components of the toolkit include metrics to ensure feasibility of trials, establish a prioritization queue for resourcing potential studies, trackers for effort and finances, and performance standards. With many patients preferring to receive their care closer to home, while also having access to the same novel approaches offered at academic medical centers, the proposal seeks to extend our clinical research studies to satellite sites. To achieve that end, Dr. Wagner-Johnston addresses strategies to create the necessary research culture to enhance enrollment. Focus will be placed on establishing leadership and providing a collaborative learning culture at the satellite sites. Rational portfolio building at the satellite sites will rely on the same metrics developed as part of the toolkit. Engagement from both physicians and prospective trial participants is essential and this proposal outlines practical approaches to attend to these concerns. Involvement in routine research meetings and recognition of physicians' effort in consenting to trials will incentivize trial participation. Outreach efforts including monthly email newsletters to referring physicians, updates to our HM website, as well as a better tool to identify potential trials for patients are planned. We will extend the ongoing work of community health educators affiliated with projects initiated by the Diversity and Inclusion in Clinical Research Program at SKCCC to include our patients with HM. The outlined research strategy seeks to improve the operational aspects beginning with pre-trial activation through study closure. Attention to increased efficiencies will be essential in bringing needed research to satellite sites. Best practices identified from this project will be readily transferrable to the entire cancer center enterprise at SKCCC and shared with other academic medical centers. As a nationally recognized lymphoma expert with a strong commitment to the NCTN and extensive knowledge in clinical research operations, Dr. Wagner-Johnston is poised to lead these efforts and successfully enhance accruals.", "keywords": [ "Academic Medical Centers", "Address", "Attention", "Award", "COVID-19 impact", "Cancer Center", "Caring", "Clinical Research", "Clinical Trials", "Community Health", "Comprehensive Cancer Center", "Consent", "Development", "Electronic Mail", "Enrollment", "Ensure", "Goals", "Health Educators", "Health system", "Hematologic Neoplasms", "Home", "Incentives", "Knowledge", "Lead", "Leadership", "Learning", "Lymphoma", "Newsletter", "Oncology", "Operations Research", "Participant", "Patients", "Performance", "Physicians", "Precision medicine trial", "Research", "Research Proposals", "Resources", "Site", "System", "Therapeutic Trials", "Time", "Update", "Work", "clinical trial enrollment", "diversity and inclusion", "feasibility trial", "improved", "meetings", "novel strategies", "operation", "outreach", "patient-level barriers", "programs", "prospective", "research study", "tool", "web site" ], "approved": true } } ], "meta": { "pagination": { "page": 1391, "pages": 1419, "count": 14184 } } }