Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1397&sort=other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=other_investigators" }, "data": [ { "type": "Grant", "id": "7315", "attributes": { "award_id": "3P50HD089922-04S1", "title": "Penn State University's Translational Center for Child Maltreatment Studies TCCMS", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 12475, "first_name": "Valerie", "last_name": "Maholmes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-04-20", "end_date": "2022-03-31", "award_amount": 160500, "principal_investigator": { "id": 12995, "first_name": "JENNIE G", "last_name": "NOLL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 833, "ror": "", "name": "PENNSYLVANIA STATE UNIVERSITY, THE", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23105, "first_name": "Hannah Milena Caroline", "last_name": "Schreier", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 833, "ror": "", "name": "PENNSYLVANIA STATE UNIVERSITY, THE", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Although emerging data regarding the current COVID-19 pandemic suggest that children and adolescents have a lower risk of being diagnosed with severe COVID-19 infections, serious adverse effects, including death, have been reported in this age group. Additionally, concerns that children and adolescents with mild COVID-19 infections continue to spread infections remain. Despite being less likely to be diagnosed with cases of COVID-19, youth's lives are profoundly impacted by the COVID-19 pandemic in numerous ways, including due to disrupted daily routines and educational experiences, reduced social contacts with peers and families, and, potentially, increased exposures to unsafe home environments, overwhelmed caregivers, incidents of domestic violence, and, possibly, incidents of child maltreatment. This highlights that youth with a history of child maltreatment may be particularly vulnerable to the direct and indirect effects of the COVID-19 pandemic seeing as they are likely to come from families already experiencing multiple hardships. This impacts a large number of youth; over one third of U.S. youth are investigated for child maltreatment (CM) before the age of 18. The proposed project will build on the currently ongoing Child Health Study (CHS; HD089922, PI: Noll, Co-I: Schreier), as part of which 775 youth aged 8-13 years who were recently investigated for CM as well as 225 comparison youth without a history of CM are being recruited and followed prospectively. Taking advantage of this unique and exceptionally well-characterized cohort, we will augment the biopsychosocial data already being collected to examine vulnerability and resilience towards COVID-19 infections among these youth, as well as how the additional stress that is currently being experienced by caregivers in the study may spill over to impact youth well-being throughout and following this pandemic. We will examine whether a broad range of physiological, e.g., endocrine, immune, and metabolic, as well as psychosocial, and demographic characteristics of youth are associated with known infections of COVID-19 or with an absence of known infections in the context of having been in close contact with individuals with known infections. Additionally, we will investigate the influence of added caregiver stress on possible exacerbations of existing youth health problems, physiological markers of stress, and new incidents of child maltreatment. Thus, by shedding light on the current and future experiences of some of society's most vulnerable individuals, the resulting data have the potential to provide a powerful jumping-off point for future intervention programs to support these youth who are and will be transitioning into adulthood in the wake of the COVID-19 pandemic. Importantly, this knowledge will also carry forward into informing responses to possible future pandemics which may have similar effects on the everyday lives of individuals.", "keywords": [ "Administrative Supplement", "Adolescent", "Adult", "Adverse effects", "Age", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caregiver Burden", "Caregiver well-being", "Caregivers", "Cessation of life", "Characteristics", "Child", "Child Abuse and Neglect", "Child Health", "Child Welfare", "Childhood", "Data", "Data Set", "Demographic Factors", "Development", "Diagnosis", "Disease Outbreaks", "Domestic Violence", "Endocrine", "Exposure to", "Family", "Financial Hardship", "Funding", "Future", "Health", "Health Care Costs", "Home environment", "Immune", "Individual", "Infection", "Inflammation", "Inflammatory", "Investigation", "Knowledge", "Life", "Light", "Link", "Measures", "Medicaid", "Metabolic", "National Institute of Child Health and Human Development", "Natural experiment", "Outcome", "Parents", "Participant", "Patient Self-Report", "Personal Satisfaction", "Persons", "Pharmaceutical Preparations", "Physiological", "Population", "Predisposition", "Preventive Intervention", "Productivity", "Prospective cohort", "Psychosocial Factor", "Recording of previous events", "Records", "Reporting", "Research Project Grants", "Risk", "Role", "Sampling", "Services", "Sexual abuse", "Societies", "Stress", "Symptoms", "Telephone", "Testing", "Trauma", "Unemployment", "Universities", "Well in self", "Youth", "abuse neglect", "age group", "aged", "anxiety symptoms", "biopsychosocial", "boys", "cardiovascular disorder risk", "case control", "cohort", "cost", "depressive symptoms", "early adolescence", "experience", "girls", "immune function", "individual variation", "interest", "intervention program", "maltreatment", "mortality", "multidimensional data", "pandemic disease", "peer", "physical abuse", "primary caregiver", "prospective", "psychosocial", "recruit", "resilience", "response", "social", "stressor" ], "approved": true } }, { "type": "Grant", "id": "7318", "attributes": { "award_id": "3R01DC016273-03S1", "title": "Administrative Supplement to The When to Worry about Language Study (W2W-L)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Deafness and Other Communication Disorders (NIDCD)" ], "program_reference_codes": [], "program_officials": [ { "id": 10587, "first_name": "Judith", "last_name": "Cooper", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-03-05", "end_date": "2023-02-28", "award_amount": 197084, "principal_investigator": { "id": 23107, "first_name": "Elizabeth Spencer", "last_name": "Norton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 317, "ror": "https://ror.org/000e0be47", "name": "Northwestern University", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23108, "first_name": "LAUREN S", "last_name": "WAKSCHLAG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 924, "ror": "", "name": "NORTHWESTERN UNIVERSITY AT CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 317, "ror": "https://ror.org/000e0be47", "name": "Northwestern University", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "– Original Submission Primary language impairment (PLI) begins early in life and affects 6-8% of children. Although language intervention is maximally effective the earlier it is delivered, normative variation in language acquisition across toddlerhood (here 24-36 months) impedes accurate identification of PLI prior to late preschool age. The proposed study introduces a novel, theoretically- grounded, neurodevelopmental framework designed to generate a sensitive and specific model to identify PLI as early as possible. Our developmentally- sensitive, translational approach introduces multiple innovations including: (1) characterizing the developmental patterning of toddler emergent language beginning at 24 mos. using state-of-the-art methods, within a large community sample; (2) incorporating EEG/ERP neural biomarkers of language into PLI risk assessment; (3) using a novel paradigm to assess the protective effects of both behavioral and neural synchronization within parent-child language transactions; and (4) consideration of irritability, a robust developmental marker of early mental health risk, to enhance identification of those language delayed toddlers at highest risk for persistence. For the proposed When to Worry about Language Study (W2W-L), we capitalize on our funded study of 350 infants (50% irritable and 50% non-irritable) (R01MH107652, Wakschlag, PI) and enrich it via recruitment of a sub-sample of 200 late talking toddlers. This will yield a large and diverse sample of 550 24-month-olds. Our key predictors will be toddler emergent language patterns (24-36 months), their neural biomarkers and synchrony within the transactional language environment. Our central outcome is primary language impairment (PLI) status at preschool age (54 mos., when PLI can be reliably evaluated), assessed via clinical gold standard expressive and receptive language abilities. SPECIFIC AIMS: AIM 1a. Evaluate accuracy of PLI prediction based on multi-component measures of language including intensive longitudinal assessments of toddler developmental precursors of key language functions at older ages, neural biomarkers. We will assess neural and linguistic processing via quantitative EEG during parent-child interaction and ERPs to speech sounds as well as during eye tracking tasks and 1b. Evaluate feasibility of creating an algorithm for early identification of PLI that can be applied in clinical practice, using cross-validation and machine learning. AIM 2: Test the hypothesis that parent-child dyadic synchrony buffers PLI risk For the first time, we combine behavioral and novel social EEG measures of parent-child synchrony during natural interaction and a custom-designed word learning task to directly test how observed (behavioral) and neural (EEG) dyadic synchrony impact word learning. AIM 3: Test whether consideration of toddler irritability enhances PLI prediction. In sum, PLI confers sustained negative effects on a variety of personal-social and academic outcomes. Pinpointing children at highest risk for PLI is critical for reducing the public health burden of PLI for children, families, and the systems supporting them, and enhancing targeted allocation of resources.", "keywords": [ "Address", "Administrative Supplement", "Adverse effects", "Affect", "African American", "Age", "Algorithms", "Behavioral", "Biological Markers", "Buffers", "COVID-19", "COVID-19 pandemic", "Caregivers", "Child", "Child Language", "Child Rearing", "Clinical", "Communities", "Custom", "Data", "Data Collection", "Development", "Early Intervention", "Early identification", "Electroencephalography", "Environment", "Family", "Family member", "Foundations", "Funding", "Goals", "Gold", "Hispanics", "Home environment", "Human Subject Research", "Illinois", "Impairment", "Individual", "Infant", "Institutes", "Interruption", "Intervention", "Language", "Language Delays", "Language Development", "Language Disorders", "Life", "Linguistics", "Machine Learning", "Measures", "Mediating", "Mental Health", "Methods", "Modeling", "Nursery Schools", "Outcome", "Parent-Child Relations", "Parents", "Participant", "Pattern", "Pediatric Hospitals", "Personal Satisfaction", "Persons", "Process", "Protocols documentation", "Public Health", "Race", "Research Activity", "Resource Allocation", "Risk", "Risk Assessment", "Sampling", "Siblings", "Speech Sound", "Stress", "Sum", "Support System", "Surveys", "Testing", "Time", "Toddler", "Transact", "Translations", "United States National Institutes of Health", "Validation", "Variant", "Visit", "base", "clinical practice", "cohort", "coronavirus disease", "design", "experience", "high risk", "innovation", "language impairment", "negative affect", "novel", "pandemic disease", "predictive modeling", "prevent", "protective effect", "recruit", "relating to nervous system", "sex", "social", "standard measure", "stress reduction", "translational approach", "tv watching", "visual tracking", "word learning" ], "approved": true } }, { "type": "Grant", "id": "7321", "attributes": { "award_id": "3R01DA047933-02S1", "title": "Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIV", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8444, "first_name": "Shelley", "last_name": "Su", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-05-15", "end_date": "2023-02-28", "award_amount": 166958, "principal_investigator": { "id": 23109, "first_name": "Conall Michael", "last_name": "O'Cleirigh", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 7958, "first_name": "MICHAEL J.", "last_name": "ZVOLENSKY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23110, "first_name": "Jasper", "last_name": "Smits", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Early data indicate that smoking increases the severity of coronavirus disease (COVID-19) symptoms. Individuals living with HIV are more likely to smoke and less likely to quit than those in the general population, placing them at high risk for poor COVID-19 outcomes. Comorbidities associated with HIV, including cardiovascular disease and chronic lung disease, further heighten risk for a severe course of COVID-19 illness, which has been linked to over 40,000 deaths in the U.S. thus far. To mitigate COVID-19 related health disparities and inform intervention strategies, it is crucial to assess the degree to which nicotine dependence and HIV disease stage affect the onset and progression of COVID-19 in smokers living with HIV. Disruptions to engagement in HIV care and antiretroviral therapy regimens may compromise efforts to maintain viral suppression and lead to increases in rates of anxiety and depression, both of which are already elevated in individuals living with HIV compared to the general population. Increases in negative affect (anxiety and depression) are established pathways to smoking relapse among smokers living with HIV who may use cigarettes to regulate their negative mood; therefore, increases in anxiety and depression resulting from the COVID-19 pandemic could impact smoking cessation and relapse. Given the primary outcomes of the parent grant, we will also examine the ways in which COVID-19 related mental health responses COVID-19influence uptake of smoking cessation treatments, smoking abstinence, and other relevant smoking outcomes. This proposed Administrative Supplement is responsive to the Notice of Special Interest regarding the Availability of Administrative Supplements Research on the 2019 Novel Coronavirus (NOSI - NOT-DA-20-047) issued by NIDA and is appropriate to PA-18-591 (Administrative Supplements to Existing NIH Grants). Specifically, our application is responsive to 3 areas of research requested by the NOSI: (1) “Research to determine whether substance use (especially smoking tobacco…) is a risk factor for the onset and progression of COVID-19,” (2) “Research on how HIV among persons who use substances may impact the onset and progression of COVID-19,” and (3) “Research using ongoing studies to understand the broad impacts of COVID-19 (e.g., anxiety...) on …, substance use, substance use disorders, and access to addiction treatment.” Through this administrative supplement application we directly address these three areas and propose the following specific aims: (1) to quantify the relationship among baseline nicotine dependence severity, baseline HIV disease stage and their interaction), with COVID-19 outcomes (COVID-19 susceptibility, clinical symptom burden, level of treatment, COVID-19 disease outcome) over up to 2 years of follow up; and (2) quantify manifestations of negative affect that have emerged in response to the COVID-19 pandemic and the degree to which these different manifestations impact uptake of smoking cessation treatments over the follow up period. We will achieve these aims by leveraging the of our parent R01 grant.", "keywords": [ "2019-nCoV", "Abstinence", "Address", "Administrative Supplement", "Adult", "Affect", "Alcohol or Other Drugs use", "Anxiety", "Area", "CD4 Positive T Lymphocytes", "COVID-19", "COVID-19 pandemic", "Cardiovascular Diseases", "Caring", "Cell Count", "Cessation of life", "China", "Chinese People", "Chronic lung disease", "Clinical", "Collaborations", "Data", "Disease", "Disease Outbreaks", "Disease Outcome", "Effectiveness", "Future", "General Population", "Grant", "HIV", "Health", "Health Services Accessibility", "Individual", "Infection", "Infrastructure", "Intervention", "Knowledge", "Lead", "Link", "Mechanical ventilation", "Mental Depression", "Mental Health", "National Institute of Drug Abuse", "Nicotine Dependence", "Outcome", "Parents", "Participant", "Pathological anxiety", "Pathway interactions", "Patients", "Persons", "Pharmaceutical Preparations", "Population", "Predisposition", "Prevalence", "Psychological Impact", "Randomized", "Recording of previous events", "Regimen", "Relapse", "Reporting", "Research", "Respiratory physiology", "Respondent", "Risk", "Risk Factors", "Sampling", "Severities", "Smoke", "Smoker", "Smoking", "Smoking Cessation Intervention", "Specific qualifier value", "Substance Use Disorder", "Surveys", "Symptoms", "Time", "Tobacco", "Tobacco use", "Uncertainty", "United States", "United States National Institutes of Health", "Viral", "Viremia", "Virus", "addiction", "adverse outcome", "antiretroviral therapy", "anxiety sensitivity", "anxiety symptoms", "cigarette smoking", "comorbidity", "coronavirus disease", "depressive symptoms", "follow-up", "health disparity", "high risk", "interest", "mortality", "negative affect", "negative mood", "non-smoker", "novel coronavirus", "overtreatment", "pandemic disease", "parent grant", "primary outcome", "psychologic", "response", "smoking abstinence", "smoking cessation", "smoking relapse", "uptake" ], "approved": true } }, { "type": "Grant", "id": "7322", "attributes": { "award_id": "3UH3OD023348-05S2", "title": "RACE, COVID-19, and Health Outcomes Among Individuals Born Preterm", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 21693, "first_name": "CLAY", "last_name": "MASH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-09-21", "end_date": "2023-08-31", "award_amount": 311000, "principal_investigator": { "id": 21807, "first_name": "Rebecca", "last_name": "Fry", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23111, "first_name": "Michael", "last_name": "O'SHEA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 817, "ror": "", "name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "This project addresses a critical gap in the understanding of potential links between race, the COVID-19 pandemic, and the well-being of children. We will evaluate these relationships by collaborating with other ECHO cohorts, thus increasing the geographical variation of our study sample. Our cohort, derived from the Extremely Low Gestational Age Newborn (ELGAN) study, provides the opportunity to evaluate relationships within subsets defined in terms of gestational age at birth. Given the high prevalence of early life adversities among individuals born extremely preterm, we anticipate finding increased vulnerability to the harmful effects of the COVID-19 pandemic. Although fewer children than adults have developed life-threatening infections due to COVID-19, the public health policies implemented to stop the spread of COVID-19 have disrupted children’s lives through economic depression, social distancing, and unprecedented educational disruptions. The shift to distance learning has changed children’s home, school, and social environments, but we know very little about the impact of these changes on children’s health and development. These disruptions may have stronger negative effects on historically underserved groups, including lower income families, as well as racial and ethnic minorities. This proposal seeks to evaluate the unintended psychosocial impacts of COVID-19 public health policies on children and families, and to examine if these effects are more prominent within lower income communities and communities of color. We examine if COVID-19 Health Policies impose more hardships on families within these groups, and if these hardships adversely affect their positive health development, as indexed by academic competence and well-being. By collaborating with cohorts comprised primarily of children born near or at term, we will also evaluate whether COVID-19 related stressors have greater impact on a particularly vulnerable group of children, i.e., those born extremely preterm. Further, we will examine if school practices related to distance learning and supportive social networks are also associated with child outcomes, independent of COVID-19 hardships. This project will identify processes by which public health policies influence families and will identify practices that promote children’s positive health development.", "keywords": [ "2019-nCoV", "Academic achievement", "Address", "Adolescent", "Adult", "Affect", "Age", "Award", "Birth", "Brain", "Buffers", "COVID-19", "COVID-19 pandemic", "Characteristics", "Child", "Child Development", "Child Health", "Child Welfare", "Collaborations", "Color", "Communities", "Competence", "Data", "Data Collection", "Development", "Distance Learning", "Economics", "Education", "Educational Models", "Emotional", "Environment", "Ethnic Origin", "Extremely low gestational age newborn", "Family", "Geography", "Gestational Age", "Health", "Health Policy", "High Prevalence", "Home environment", "Individual", "Infection", "Inflammation", "Learning", "Life", "Link", "Low income", "Magnetic Resonance Imaging", "Measures", "Mental Depression", "Modeling", "Neighborhoods", "Neurodevelopmental Impairment", "Outcome", "Parents", "Participant", "Personal Satisfaction", "Play", "Policies", "Policy Developments", "Pregnancy", "Process", "Public Health", "Questionnaires", "Race", "Records", "Reporting", "Research", "Research Personnel", "Resources", "Sampling Studies", "Schools", "Services", "Shapes", "Social Distance", "Social Environment", "Social Network", "Social support", "Socioeconomic Status", "Subgroup", "Surveys", "Testing", "Time", "Variant", "Vulnerable Populations", "Well in self", "Work", "base", "cohort", "early life adversity", "ethnic minority population", "experience", "family influence", "family support", "geographic difference", "gray matter", "indexing", "insight", "low socioeconomic status", "lower income families", "mortality", "multidisciplinary", "novel", "pandemic disease", "prenatal exposure", "programs", "psychosocial", "racial minority", "response", "segregation", "sociodemographic variables", "socioeconomic disadvantage", "stressor", "white matter" ], "approved": true } }, { "type": "Grant", "id": "7328", "attributes": { "award_id": "3P20CA233307-02S1", "title": "UChicago Interdisciplinary Cancer Health Disparities SPORE", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 23115, "first_name": "Tiffany A", "last_name": "Wallace", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-09-01", "end_date": "2021-08-31", "award_amount": 162000, "principal_investigator": { "id": 23116, "first_name": "Dezheng", "last_name": "Huo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23117, "first_name": "Rita", "last_name": "Nanda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23118, "first_name": "OLUFUNMILAYO F.", "last_name": "OLOPADE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOTCA-20-042. The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a public health and economic emergency that has disrupted the lives of breast cancer patients. Unfortunately, it has hit the United States heavily with more than 1.7 million people having been infected and more than 100,000 lives lost to date. While old age and having comorbidities are risk factors for dying from COVID-19, there is also a racial disparity in COVID-19 severity, with black and Latino patients in urban centers dying disproportionately from COVID-19. Breast cancer is the most common malignancy in women, with over 3.8 million women living in the United States with a history of invasive breast cancer. African Americans with breast cancer have an elevated risk of all-cause mortality and breast cancer-specific mortality. During the COVID-19 pandemic, it is important to understand the impact of SARS-CoV-2 infection and COVID-19 on breast cancer disease progression, care delivery, and survivorship including quality of life during and after the COVID-19 outbreak. In response to the needs of patients participating in our P20 funded UChicago Interdisciplinary Health Disparities SPORE and to address these knowledge gaps, we propose to engage with the Community by conducting an online survey, reviewing electronic health records, and searching the National Death Index to determine status of 3,059 breast cancer patients in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort. The project has three specific aims: First, we will evaluate the extent of treatment interruption because of COVID-19 outbreak, and understand the utilization and satisfaction with Telehealth. Second, we will conduct a holistic evaluation of COVID-19 and mitigation efforts on loneliness, anxiety, stress, economic impact, and lack of resources among breast cancer patients. Third, we will estimate the coronavirus infection rate, severity and case-fatality rate of COVID-19, and identify factors associated with severity and case-fatality rate of COVID-19. For each aim, we will examine racial differences to understand whether COVID-19 has worsened previously identified mortality gap in the Cohort. The Supplementary Project will greatly enhance our SPORE P20 program by supporting additional interviews and follow-up of the cancer cohort members, and will generate necessary data regarding the impact of COVID-19 epidemic and lockdown on translational research to close the mortality gap in our proposed full SPORE application. These data are critical for guiding both community level interventions and health systems adaptation to support high-risk patients in the era of COVID-19.", "keywords": [ "2019-nCoV", "Address", "Admission activity", "Affect", "African American", "Age", "Anxiety", "Area", "Breast Cancer Patient", "Breast Cancer Treatment", "Breast Cancer survivor", "COVID-19", "COVID-19 pandemic", "Cancer Patient", "Cancer Survivor", "Case Fatality Rates", "Catchment Area", "Caucasians", "Cessation of life", "Chicago", "Chronic lung disease", "Code", "Communities", "Coronavirus", "Coronavirus Infections", "County", "Data", "Diabetes Mellitus", "Disease", "Disease Outbreaks", "Disease Progression", "Elderly", "Electronic Health Record", "Emergency Situation", "Enrollment", "Epidemiology", "Evaluation", "Exposure to", "Funding", "Grant", "Health system", "Healthcare", "High-Risk Cancer", "Histologic", "Hypertension", "Illinois", "Incidence", "Infection", "Interruption", "Intervention", "Interview", "Knowledge", "Latino", "Loneliness", "Malignant Neoplasms", "Outcome", "Patients", "Persons", "Phenotype", "Population", "Psychological Impact", "Public Health", "Quality of life", "Race", "Recording of previous events", "Resources", "Risk", "Risk Factors", "Severities", "Severity of illness", "Side", "Social isolation", "Social support", "Stress", "Surveys", "Telemedicine", "Translational Research", "United States", "Universities", "Woman", "aged", "cancer health disparity", "cancer therapy", "care delivery", "cohort", "comorbidity", "cooking", "economic impact", "ethnic minority population", "follow-up", "health disparity", "health economics", "high risk", "indexing", "infection rate", "interest", "malignant breast neoplasm", "member", "metropolitan", "mortality", "news", "novel coronavirus", "pandemic disease", "programs", "racial and ethnic", "racial difference", "racial disparity", "racial health disparity", "response", "satisfaction", "screening guidelines", "survivorship", "telehealth", "ventilation" ], "approved": true } }, { "type": "Grant", "id": "7328", "attributes": { "award_id": "3P20CA233307-02S1", "title": "UChicago Interdisciplinary Cancer Health Disparities SPORE", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 23115, "first_name": "Tiffany A", "last_name": "Wallace", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2018-09-01", "end_date": "2021-08-31", "award_amount": 162000, "principal_investigator": { "id": 23116, "first_name": "Dezheng", "last_name": "Huo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23117, "first_name": "Rita", "last_name": "Nanda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23118, "first_name": "OLUFUNMILAYO F.", "last_name": "OLOPADE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 289, "ror": "https://ror.org/024mw5h28", "name": "University of Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOTCA-20-042. The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a public health and economic emergency that has disrupted the lives of breast cancer patients. Unfortunately, it has hit the United States heavily with more than 1.7 million people having been infected and more than 100,000 lives lost to date. While old age and having comorbidities are risk factors for dying from COVID-19, there is also a racial disparity in COVID-19 severity, with black and Latino patients in urban centers dying disproportionately from COVID-19. Breast cancer is the most common malignancy in women, with over 3.8 million women living in the United States with a history of invasive breast cancer. African Americans with breast cancer have an elevated risk of all-cause mortality and breast cancer-specific mortality. During the COVID-19 pandemic, it is important to understand the impact of SARS-CoV-2 infection and COVID-19 on breast cancer disease progression, care delivery, and survivorship including quality of life during and after the COVID-19 outbreak. In response to the needs of patients participating in our P20 funded UChicago Interdisciplinary Health Disparities SPORE and to address these knowledge gaps, we propose to engage with the Community by conducting an online survey, reviewing electronic health records, and searching the National Death Index to determine status of 3,059 breast cancer patients in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort. The project has three specific aims: First, we will evaluate the extent of treatment interruption because of COVID-19 outbreak, and understand the utilization and satisfaction with Telehealth. Second, we will conduct a holistic evaluation of COVID-19 and mitigation efforts on loneliness, anxiety, stress, economic impact, and lack of resources among breast cancer patients. Third, we will estimate the coronavirus infection rate, severity and case-fatality rate of COVID-19, and identify factors associated with severity and case-fatality rate of COVID-19. For each aim, we will examine racial differences to understand whether COVID-19 has worsened previously identified mortality gap in the Cohort. The Supplementary Project will greatly enhance our SPORE P20 program by supporting additional interviews and follow-up of the cancer cohort members, and will generate necessary data regarding the impact of COVID-19 epidemic and lockdown on translational research to close the mortality gap in our proposed full SPORE application. These data are critical for guiding both community level interventions and health systems adaptation to support high-risk patients in the era of COVID-19.", "keywords": [ "2019-nCoV", "Address", "Admission activity", "Affect", "African American", "Age", "Anxiety", "Area", "Breast Cancer Patient", "Breast Cancer Treatment", "Breast Cancer survivor", "COVID-19", "COVID-19 pandemic", "Cancer Patient", "Cancer Survivor", "Case Fatality Rates", "Catchment Area", "Caucasians", "Cessation of life", "Chicago", "Chronic lung disease", "Code", "Communities", "Coronavirus", "Coronavirus Infections", "County", "Data", "Diabetes Mellitus", "Disease", "Disease Outbreaks", "Disease Progression", "Elderly", "Electronic Health Record", "Emergency Situation", "Enrollment", "Epidemiology", "Evaluation", "Exposure to", "Funding", "Grant", "Health system", "Healthcare", "High-Risk Cancer", "Histologic", "Hypertension", "Illinois", "Incidence", "Infection", "Interruption", "Intervention", "Interview", "Knowledge", "Latino", "Loneliness", "Malignant Neoplasms", "Outcome", "Patients", "Persons", "Phenotype", "Population", "Psychological Impact", "Public Health", "Quality of life", "Race", "Recording of previous events", "Resources", "Risk", "Risk Factors", "Severities", "Severity of illness", "Side", "Social isolation", "Social support", "Stress", "Surveys", "Telemedicine", "Translational Research", "United States", "Universities", "Woman", "aged", "cancer health disparity", "cancer therapy", "care delivery", "cohort", "comorbidity", "cooking", "economic impact", "ethnic minority population", "follow-up", "health disparity", "health economics", "high risk", "indexing", "infection rate", "interest", "malignant breast neoplasm", "member", "metropolitan", "mortality", "news", "novel coronavirus", "pandemic disease", "programs", "racial and ethnic", "racial difference", "racial disparity", "racial health disparity", "response", "satisfaction", "screening guidelines", "survivorship", "telehealth", "ventilation" ], "approved": true } }, { "type": "Grant", "id": "7332", "attributes": { "award_id": "3R34DA050261-01S2", "title": "3/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 153047, "principal_investigator": { "id": 23120, "first_name": "ASHLEY", "last_name": "ACHESON", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 1427, "ror": "", "name": "ARKANSAS CHILDREN'S HOSPITAL RES INST", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23121, "first_name": "Xiawei", "last_name": "Ou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1427, "ror": "", "name": "ARKANSAS CHILDREN'S HOSPITAL RES INST", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has affected the mental and physical health of children and their parents. The pandemic has also affected the ability to conduct in-person research at most institutions across the United States. However, recent technological advances may allow many in-person assessments to transition to virtual formats. There is an urgent need to develop virtual versions of currently used assessments of the home environment and parent-child interactions, and to concurrently study the effect of the COVID-19 pandemic on family relationships. The proposed project seeks to address this urgent need by building upon ongoing research efforts among three sites from the NIH HEALthy Brains and Cognitive Development (HBCD) study: Arkansas Children’s Research Institute, Cincinnati Children’s Hospital, and the University of North Carolina at Chapel Hill. We will develop and test a virtual version of the HOME Inventory in 90 caregivers with infants between 6-18 months of age. We will validate this virtual version by performing in-person HOME Inventory assessments in 45 of these dyads. In all participants, we will use a standard questionnaire to assess COVID- 19 exposure and impact. Finally, we will examine associations between regional and temporal variations in COVID-19 exposure and impact and dimensions of the HOME Inventory. The results of this study will be used to finalize the development of a virtual HOME Inventory protocol that can be widely used in future studies, including the HBCD Phase II study.", "keywords": [ "Address", "Adult", "Affect", "Age-Months", "Anxiety", "Arkansas", "Behavior", "Brain", "COVID-19", "COVID-19 pandemic", "Caregivers", "Child", "Child Development", "Child Health", "Child Rearing", "Cognitive", "Cohort Studies", "Development", "Dimensions", "Environment", "Equipment", "Equipment and supply inventories", "Family", "Family Relationship", "Future", "Geography", "Home environment", "Individual", "Infant", "Infection", "Institution", "Manuals", "Measurement", "Measures", "Mental Health", "Mothers", "North Carolina", "Parent-Child Relations", "Parents", "Participant", "Pediatric Hospitals", "Perinatal", "Persons", "Phase", "Protocols documentation", "Psychometrics", "Questionnaires", "Research", "Research Institute", "Safety", "Schools", "Site", "Stress", "Surveys", "Testing", "Time", "Training", "Transcend", "Uncertainty", "United States", "United States National Institutes of Health", "Universities", "Validation", "Variant", "Visit", "cognitive development", "cost", "experience", "innovation", "learning materials", "pandemic disease", "phase 1 study", "phase 2 study", "physical conditioning", "social", "virtual" ], "approved": true } }, { "type": "Grant", "id": "7337", "attributes": { "award_id": "3UH3OD023285-05S2", "title": "Prenatal Exposures and Child Health Outcomes: A Statewide Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10604, "first_name": "SUSAN ALISON", "last_name": "Laessig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-09-21", "end_date": "2021-08-31", "award_amount": 305679, "principal_investigator": { "id": 23123, "first_name": "Charles James", "last_name": "Barone", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23124, "first_name": "MICHAEL R.", "last_name": "ELLIOTT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23125, "first_name": "Jean Marie", "last_name": "Kerver", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23126, "first_name": "Patricia", "last_name": "McKane", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23127, "first_name": "NIGEL SEFTON", "last_name": "PANETH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23128, "first_name": "Douglas M", "last_name": "Ruden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Evidence from epidemiologic studies demonstrates the negative effects of both chronic and acute stress during gestation. These effects may occur perinatally or later in the child's life. The COVID-19 global pandemic has led to unprecedented mass disruption of social and financial security as well as changes in medical care delivery. These conditions are causing elevated levels of distress even for portions of the population that may have previously been protected from psychosocial stress. Of particular concern for pregnant women and their children, there may be direct biological effects related to infection with SARS-CoV-2 as well as substantial indirect psychosocial effects during critical periods of development with long-lasting impact on children relevant to the Environmental Child Health Outcomes (ECHO) program. This proposal addresses how psychosocial stress related to the COVID pandemic may impact perinatal and neurodevelopmental outcomes. Furthermore, evidence suggests that psychosocial stress is associated with both the gastrointestinal and vaginal microbiomes. Therefore, we will determine if maternal microbiomes or infant microbiomes mediate the impact of psychosocial stress on perinatal and neurodevelopmental outcomes. In aim 1, we address the maternal microbes and their role in mediating perinatal outcomes caused by maternal psychosocial stress during pregnancy. In aim 2, we focus on maternal psychosocial stress and its impact on neurodevelopment as mediated by the changes to the infant microbiota. We will examine these objectives in the context of our ongoing work, and as an extension of the parent grant (UG3/UH3OD023285, Paneth), where our organizing principle is that for many environmental exposures the most sensitive period of risk for child health is pregnancy and the perinatal period. The parent grant explores three primary exposures: toxic, nutritional, and inflammatory in a stratified random sample of state births recruited in the first trimester of pregnancy. Of the planned 1,100 new enrollments of cohort dyads into ECHO, more than 700 pregnant women have been consented, and, with a 75% follow up rate, more than 400 children have already been seen in infancy. Over 300 women are expected to be enrolled during the project period. While this research will leverage the local ECHO cohort, the project is designed to engage ECHO team science through two distinct but complementary ECHO-wide projects: (1) incorporation of data from two cohorts (O'Conner & Deoni) to address the aims proposed above and (2) provision of data and biospecimens to separate COVID supplement (Transande) which addresses SARS-CoV-2 seropositivity/COVID illness as well as psychosocial stress (assessed via questionnaire and cortisol measured in hair) as they relate to shortened gestation and other perinatal outcomes. Our efforts will not only inform the specific hypotheses being tested but will also inform “touch-free” methods for sample collection and patient interaction. The work proposed herein complements the parent grant by addressing an exposure (maternal psychosocial stress during a time of pandemic), not included in the parent grant, and at least two of ECHO's outcomes (PPP and neurodevelopment).", "keywords": [ "2019-nCoV", "Address", "Age", "Age-Months", "Archives", "Biological", "Birth", "COVID-19", "COVID-19 pandemic", "Child", "Child Health", "Chronic stress", "Clinical Research", "Collaborations", "Collection", "Complement", "Consent", "Data", "Development", "Distress", "Enrollment", "Environment", "Environmental Exposure", "First Pregnancy Trimester", "Generations", "Hair", "Health", "Hydrocortisone", "Infant", "Infection", "Inflammatory", "Intervention", "Length", "Life", "Link", "Maternal and Child Health", "Measures", "Mediating", "Medical", "Methods", "Michigan", "Microbe", "Mission", "Neurocognitive", "Nutritional", "Outcome", "Patients", "Perinatal", "Population", "Pregnancy", "Pregnant Women", "Procedures", "Psychosocial Stress", "Public Health", "Questionnaires", "Research", "Risk", "Role", "Sampling", "Science", "Security", "Shotguns", "Symptoms", "Testing", "Third Pregnancy Trimester", "Time", "Touch sensation", "Toxicant exposure", "Treatment/Psychosocial Effects", "Vertical Disease Transmission", "Woman", "Work", "acute stress", "care delivery", "cohort", "coronavirus disease", "critical period", "design", "epidemiology study", "experience", "fecal microbiome", "fecal microbiota", "follow-up", "gut microbiome", "gut microbiota", "infancy", "maternal microbiome", "maternal stress", "metagenomic sequencing", "microbial", "microbiome", "microbiome alteration", "microbiota", "neurodevelopment", "neurodevelopmental effect", "novel", "offspring", "pandemic disease", "parent grant", "perinatal outcomes", "perinatal period", "preclinical study", "prenatal exposure", "programs", "recruit", "sample collection", "seropositive", "social", "vaginal microbiome", "vaginal microbiota" ], "approved": true } }, { "type": "Grant", "id": "7337", "attributes": { "award_id": "3UH3OD023285-05S2", "title": "Prenatal Exposures and Child Health Outcomes: A Statewide Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10604, "first_name": "SUSAN ALISON", "last_name": "Laessig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-09-21", "end_date": "2021-08-31", "award_amount": 305679, "principal_investigator": { "id": 23123, "first_name": "Charles James", "last_name": "Barone", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23124, "first_name": "MICHAEL R.", "last_name": "ELLIOTT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23125, "first_name": "Jean Marie", "last_name": "Kerver", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23126, "first_name": "Patricia", "last_name": "McKane", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23127, "first_name": "NIGEL SEFTON", "last_name": "PANETH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23128, "first_name": "Douglas M", "last_name": "Ruden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Evidence from epidemiologic studies demonstrates the negative effects of both chronic and acute stress during gestation. These effects may occur perinatally or later in the child's life. The COVID-19 global pandemic has led to unprecedented mass disruption of social and financial security as well as changes in medical care delivery. These conditions are causing elevated levels of distress even for portions of the population that may have previously been protected from psychosocial stress. Of particular concern for pregnant women and their children, there may be direct biological effects related to infection with SARS-CoV-2 as well as substantial indirect psychosocial effects during critical periods of development with long-lasting impact on children relevant to the Environmental Child Health Outcomes (ECHO) program. This proposal addresses how psychosocial stress related to the COVID pandemic may impact perinatal and neurodevelopmental outcomes. Furthermore, evidence suggests that psychosocial stress is associated with both the gastrointestinal and vaginal microbiomes. Therefore, we will determine if maternal microbiomes or infant microbiomes mediate the impact of psychosocial stress on perinatal and neurodevelopmental outcomes. In aim 1, we address the maternal microbes and their role in mediating perinatal outcomes caused by maternal psychosocial stress during pregnancy. In aim 2, we focus on maternal psychosocial stress and its impact on neurodevelopment as mediated by the changes to the infant microbiota. We will examine these objectives in the context of our ongoing work, and as an extension of the parent grant (UG3/UH3OD023285, Paneth), where our organizing principle is that for many environmental exposures the most sensitive period of risk for child health is pregnancy and the perinatal period. The parent grant explores three primary exposures: toxic, nutritional, and inflammatory in a stratified random sample of state births recruited in the first trimester of pregnancy. Of the planned 1,100 new enrollments of cohort dyads into ECHO, more than 700 pregnant women have been consented, and, with a 75% follow up rate, more than 400 children have already been seen in infancy. Over 300 women are expected to be enrolled during the project period. While this research will leverage the local ECHO cohort, the project is designed to engage ECHO team science through two distinct but complementary ECHO-wide projects: (1) incorporation of data from two cohorts (O'Conner & Deoni) to address the aims proposed above and (2) provision of data and biospecimens to separate COVID supplement (Transande) which addresses SARS-CoV-2 seropositivity/COVID illness as well as psychosocial stress (assessed via questionnaire and cortisol measured in hair) as they relate to shortened gestation and other perinatal outcomes. Our efforts will not only inform the specific hypotheses being tested but will also inform “touch-free” methods for sample collection and patient interaction. The work proposed herein complements the parent grant by addressing an exposure (maternal psychosocial stress during a time of pandemic), not included in the parent grant, and at least two of ECHO's outcomes (PPP and neurodevelopment).", "keywords": [ "2019-nCoV", "Address", "Age", "Age-Months", "Archives", "Biological", "Birth", "COVID-19", "COVID-19 pandemic", "Child", "Child Health", "Chronic stress", "Clinical Research", "Collaborations", "Collection", "Complement", "Consent", "Data", "Development", "Distress", "Enrollment", "Environment", "Environmental Exposure", "First Pregnancy Trimester", "Generations", "Hair", "Health", "Hydrocortisone", "Infant", "Infection", "Inflammatory", "Intervention", "Length", "Life", "Link", "Maternal and Child Health", "Measures", "Mediating", "Medical", "Methods", "Michigan", "Microbe", "Mission", "Neurocognitive", "Nutritional", "Outcome", "Patients", "Perinatal", "Population", "Pregnancy", "Pregnant Women", "Procedures", "Psychosocial Stress", "Public Health", "Questionnaires", "Research", "Risk", "Role", "Sampling", "Science", "Security", "Shotguns", "Symptoms", "Testing", "Third Pregnancy Trimester", "Time", "Touch sensation", "Toxicant exposure", "Treatment/Psychosocial Effects", "Vertical Disease Transmission", "Woman", "Work", "acute stress", "care delivery", "cohort", "coronavirus disease", "critical period", "design", "epidemiology study", "experience", "fecal microbiome", "fecal microbiota", "follow-up", "gut microbiome", "gut microbiota", "infancy", "maternal microbiome", "maternal stress", "metagenomic sequencing", "microbial", "microbiome", "microbiome alteration", "microbiota", "neurodevelopment", "neurodevelopmental effect", "novel", "offspring", "pandemic disease", "parent grant", "perinatal outcomes", "perinatal period", "preclinical study", "prenatal exposure", "programs", "recruit", "sample collection", "seropositive", "social", "vaginal microbiome", "vaginal microbiota" ], "approved": true } }, { "type": "Grant", "id": "7337", "attributes": { "award_id": "3UH3OD023285-05S2", "title": "Prenatal Exposures and Child Health Outcomes: A Statewide Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10604, "first_name": "SUSAN ALISON", "last_name": "Laessig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-09-21", "end_date": "2021-08-31", "award_amount": 305679, "principal_investigator": { "id": 23123, "first_name": "Charles James", "last_name": "Barone", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23124, "first_name": "MICHAEL R.", "last_name": "ELLIOTT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23125, "first_name": "Jean Marie", "last_name": "Kerver", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23126, "first_name": "Patricia", "last_name": "McKane", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23127, "first_name": "NIGEL SEFTON", "last_name": "PANETH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 23128, "first_name": "Douglas M", "last_name": "Ruden", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Evidence from epidemiologic studies demonstrates the negative effects of both chronic and acute stress during gestation. These effects may occur perinatally or later in the child's life. The COVID-19 global pandemic has led to unprecedented mass disruption of social and financial security as well as changes in medical care delivery. These conditions are causing elevated levels of distress even for portions of the population that may have previously been protected from psychosocial stress. Of particular concern for pregnant women and their children, there may be direct biological effects related to infection with SARS-CoV-2 as well as substantial indirect psychosocial effects during critical periods of development with long-lasting impact on children relevant to the Environmental Child Health Outcomes (ECHO) program. This proposal addresses how psychosocial stress related to the COVID pandemic may impact perinatal and neurodevelopmental outcomes. Furthermore, evidence suggests that psychosocial stress is associated with both the gastrointestinal and vaginal microbiomes. Therefore, we will determine if maternal microbiomes or infant microbiomes mediate the impact of psychosocial stress on perinatal and neurodevelopmental outcomes. In aim 1, we address the maternal microbes and their role in mediating perinatal outcomes caused by maternal psychosocial stress during pregnancy. In aim 2, we focus on maternal psychosocial stress and its impact on neurodevelopment as mediated by the changes to the infant microbiota. We will examine these objectives in the context of our ongoing work, and as an extension of the parent grant (UG3/UH3OD023285, Paneth), where our organizing principle is that for many environmental exposures the most sensitive period of risk for child health is pregnancy and the perinatal period. The parent grant explores three primary exposures: toxic, nutritional, and inflammatory in a stratified random sample of state births recruited in the first trimester of pregnancy. Of the planned 1,100 new enrollments of cohort dyads into ECHO, more than 700 pregnant women have been consented, and, with a 75% follow up rate, more than 400 children have already been seen in infancy. Over 300 women are expected to be enrolled during the project period. While this research will leverage the local ECHO cohort, the project is designed to engage ECHO team science through two distinct but complementary ECHO-wide projects: (1) incorporation of data from two cohorts (O'Conner & Deoni) to address the aims proposed above and (2) provision of data and biospecimens to separate COVID supplement (Transande) which addresses SARS-CoV-2 seropositivity/COVID illness as well as psychosocial stress (assessed via questionnaire and cortisol measured in hair) as they relate to shortened gestation and other perinatal outcomes. Our efforts will not only inform the specific hypotheses being tested but will also inform “touch-free” methods for sample collection and patient interaction. The work proposed herein complements the parent grant by addressing an exposure (maternal psychosocial stress during a time of pandemic), not included in the parent grant, and at least two of ECHO's outcomes (PPP and neurodevelopment).", "keywords": [ "2019-nCoV", "Address", "Age", "Age-Months", "Archives", "Biological", "Birth", "COVID-19", "COVID-19 pandemic", "Child", "Child Health", "Chronic stress", "Clinical Research", "Collaborations", "Collection", "Complement", "Consent", "Data", "Development", "Distress", "Enrollment", "Environment", "Environmental Exposure", "First Pregnancy Trimester", "Generations", "Hair", "Health", "Hydrocortisone", "Infant", "Infection", "Inflammatory", "Intervention", "Length", "Life", "Link", "Maternal and Child Health", "Measures", "Mediating", "Medical", "Methods", "Michigan", "Microbe", "Mission", "Neurocognitive", "Nutritional", "Outcome", "Patients", "Perinatal", "Population", "Pregnancy", "Pregnant Women", "Procedures", "Psychosocial Stress", "Public Health", "Questionnaires", "Research", "Risk", "Role", "Sampling", "Science", "Security", "Shotguns", "Symptoms", "Testing", "Third Pregnancy Trimester", "Time", "Touch sensation", "Toxicant exposure", "Treatment/Psychosocial Effects", "Vertical Disease Transmission", "Woman", "Work", "acute stress", "care delivery", "cohort", "coronavirus disease", "critical period", "design", "epidemiology study", "experience", "fecal microbiome", "fecal microbiota", "follow-up", "gut microbiome", "gut microbiota", "infancy", "maternal microbiome", "maternal stress", "metagenomic sequencing", "microbial", "microbiome", "microbiome alteration", "microbiota", "neurodevelopment", "neurodevelopmental effect", "novel", "offspring", "pandemic disease", "parent grant", "perinatal outcomes", "perinatal period", "preclinical study", "prenatal exposure", "programs", "recruit", "sample collection", "seropositive", "social", "vaginal microbiome", "vaginal microbiota" ], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1397, "count": 13961 } } }