Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=funder
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=funder", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=funder", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=funder", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=funder" }, "data": [ { "type": "Grant", "id": "11739", "attributes": { "award_id": "1U18FD008004-01", "title": "COVID-19: Viral whole genome sequencing protocols for routine application at veterinary diagnostic laboratories", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 26272, "first_name": "Megan", "last_name": "Miller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2024-06-30", "award_amount": 83734, "principal_investigator": { "id": 26360, "first_name": "Albert", "last_name": "Rovira", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 764, "ror": "https://ror.org/017zqws13", "name": "University of Minnesota", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "DNA or RNA sequencing is an important tool for viral strain identification and characterization. During the last ten years advances in next generation sequencing (NGS) technologies have enhanced the capabilities of viral sequencing. However, NGS is expensive and requires advanced equipment and bioinformatics expertise. For those reasons, its adoption as a routine diagnostic service at veterinary diagnostic laboratories (VDLs) has been slow. An additional complication of the implementation of NGS in VDLs is the variety of platforms available, and the lack of practical information available to a laboratory to select the right platform. Some platforms can be less expensive upfront but require a larger expense in supplies per sample. Other platforms may be an inexpensive option, but are not well suited to run multiple samples at a time. On the other hand, some platforms may require more labor than others. Unfortunately, there is probably not a single platform or a single protocol that suits each VDL. There are hundreds of studies being published every week on NGS. However, they are mainly research papers, with results that cannot be readily applied to routine diagnostics. Therefore, there is a need for studies that provide practical recommendations for the use of NGS technologies in routine veterinary diagnostics. The University of Minnesota VDL is well positioned to provide this information. Our current NGS section has access to multiple sequencing platforms, as well as expertise in molecular diagnostics and bioinformatics. The objective of this study is to develop practical recommendations for the application of viral whole genome sequencing at VDLs. These recommendations will be applicable to VDLs in the VetLIRN network and will enhance the sequencing capabilities of the network as a whole. Three different viruses will be sequenced in this study: Severe Acute Respiratory Syndrome Cornavirus-2 (SARS-CoV-2), Porcine Epidemic Diarrhea Virus (PEDV) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Three different platforms will be assessed: Oxford Nanopore’s MinIon, Illumina’s iSeq and Illumina’s MiSeq. Three different batch sizes will be evaluated: 1 sample, 4 samples and 8 samples. These are sample sizes that are realistic for a VDL that is planning on performing one or two runs per week. Three main types of outcome will be evaluated for each different protocol: a) Accuracy; b) Cost: equipment, maintenance, labor (molecular diagnostics technician), labor (bioinformatician); and c) Turnaround time: sample processing time, library preparation time, sequencing time, analysis time. The final report will include tabulated expected outcomes (cost and turnaround time) for each combination of sequencing platform and sample size.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11740", "attributes": { "award_id": "1P01HL162607-01A1", "title": "Mechanisms Regulating Lung Injury and Early Lung Fibrosis", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22589, "first_name": "CHRISTIAN RENE", "last_name": "Gomez", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2028-06-30", "award_amount": 2450727, "principal_investigator": { "id": 27613, "first_name": "David Albert", "last_name": "Schwartz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall goal of this Program is to understand the role of MUC5B in establishing a vulnerable lung and the transition of a vulnerable lung to a lung characterized by persistent injury of bronchoalveolar epithelia and activation of lung fibroblasts. While our findings have identified a novel molecule (MUC5B) and target (bronchoalveolar epithelia) for IPF, only ≈5% of individuals with this genetic variant develop usual interstitial pneumonia (UIP) on HRCT scan, suggesting the need for another insult (a ‘second hit’) to initiate and intensify the fibroproliferative process. Based on our preliminary findings, we postulate that while overexpression of MUC5B places individuals at risk of developing IPF by causing persistent homeostatic ER stress of bronchiolar epithelia, fibroblast recruitment and pro-fibrotic programming requires a second hit to the bronchiolar epithelia resulting in detrimental ER stress and recruitment and activation of fibroblasts. Our Program includes 3 Scientific Projects and 4 Cores, and our unifying scientific themes include: 1) IPF is initiated by enhanced expression of MUC5B (first hit) that establish a vulnerable lung characterized by persistent homeostatic ER stress (without substantial UPR or apoptosis); 2) secondary injury to the bronchoalveolar epithelia results in transition of a vulnerable lung to a lung characterized by detrimental ER stress (involving substantial UPR and apoptosis) and the development of microscopic bronchiolar-centric fibroproliferation; and 3) understanding etiologic and initial biological responses in distal airway epithelia and AEC2 cells, and the interaction of bronchoalveolar epithelia with lung fibroblasts will create opportunities for disease prevention and early intervention. The overarching hypothesis of our Program is that the development of IPF requires two hits, MUC5B overexpression in bronchiolar epithelia that induces a homeostatic, priming response and subsequent injury of the bronchiolar epithelia that results in detrimental ER stress, aberrant epithelia, and fibroblast activation. Project 1 will definitively address the drivers of MUC5B overexpression, Project 2 will identify the determinants of epithelial injury and detrimental ER stress, and Project 3 will investigate the molecular interface between MUC5B-induced epithelial injury and fibroblast activation. At the completion of this highly integrated Program, we will have: 1) established the basic molecular mechanisms that regulate MUC5B-induced injury/repair process in fibroproliferation; 2) defined mechanisms that will create a roadmap for primary and secondary intervention in IPF; and 3) provided a rationale and targets for early intervention in a disease that remains a significant public health problem and may increase post-Covid.", "keywords": [ "Address", "Aging", "Apoptosis", "Apoptosis Promoter", "Biological", "Bleomycin", "Bronchioles", "Cells", "Cyst", "Development", "Disease", "Disease model", "Distal", "Dominant Genetic Conditions", "Early Intervention", "Enhancers", "Epigenetic Process", "Epithelial", "Epithelial Cells", "Etiology", "Event", "Exposure to", "Fibroblasts", "Fibrosis", "Functional disorder", "Goals", "Heat shock proteins", "In Vitro", "Individual", "Inflammation", "Injury", "Intervention", "Lung", "MUC5B gene", "Microscopic", "Modeling", "Molecular", "Mus", "Pathogenesis", "Pathogenicity", "Pathologic", "Patients", "Phenotype", "Physiological", "Predisposition", "Process", "Public Health", "Pulmonary Fibrosis", "Reporting", "Research", "Risk", "Risk Factors", "Role", "Scanning", "Stress", "Structure of parenchyma of lung", "Tobacco smoke", "Usual Interstitial Pneumonia", "Variant", "airway epithelium", "alveolar epithelium", "biological adaptation to stress", "disorder prevention", "drug development", "endoplasmic reticulum stress", "epigenetic regulation", "epithelial injury", "gain of function", "genetic variant", "idiopathic pulmonary fibrosis", "injury and repair", "lung injury", "new therapeutic target", "non-genetic", "novel", "overexpression", "post-COVID-19", "prevent", "preventive intervention", "programs", "promoter", "recruit", "respiratory", "response" ], "approved": true } }, { "type": "Grant", "id": "11741", "attributes": { "award_id": "1U18FD008012-01", "title": "Implementation of a liquid handler that can increase capacity of SARS-CoV-2 sequencing in animals with COVID-19.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 26272, "first_name": "Megan", "last_name": "Miller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2024-06-30", "award_amount": 60154, "principal_investigator": { "id": 24728, "first_name": "Brianna", "last_name": "Stenger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1775, "ror": "https://ror.org/05h1bnb22", "name": "North Dakota State University", "address": "", "city": "", "state": "ND", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1775, "ror": "https://ror.org/05h1bnb22", "name": "North Dakota State University", "address": "", "city": "", "state": "ND", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall goal of this project is to purchase equipment that will increase capacity and speed up the library prep workflow and whole genome sequencing of the SARS-CoV-2 virus in companion animals by implementing an automated library prep process (NEBNext® ARTIC SARS-CoV-2 Companion Kit with ARTIC primers) and adding higher computing capabilities. Automating the library prep process with an affordable and versatile Opentron OT-2 liquid handling robot, in a one-way sequencing workflow, will benefit the laboratory by increasing throughput; improving sample consistency; minimizing contamination; freeing up hands-on time; reducing technician strain and fatigue; and minimize tech errors. Installation of a high-end computer workstation dedicated to sequencing and bioinformatics will significantly speed up the basecalling process and SARS-CoV-2 strain identification. This equipment proposal has three specific aims. 1) Purchase and install an Opentron OT-2 liquid handling robot in the new NDSU-VDL Sequencing Laboratory Section to maintain a one-way next-generation sequencing (NGS) workflow that will minimize contamination. The NDSU-VDL is familiar with the operation of OT-2 robots and hands-on library preparation. 2) Write a custom protocol in Python script for the OT-2 robot to automate the library prep steps for the NEBNext ARTIC SARS-CoV-2 Companion Kit for Oxford Nanopore Technologies (MinION) sequencers. The script will be made freely available to OT-2 users through protocol.io and/or github. 3) Purchase and install a high-end computer workstation to run MinION sequencers, complete basecalling, and for downstream bioinformatic analyses on SARS-CoV-2 companion animal samples (i.e. feline and canine respiratory swabs).", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11742", "attributes": { "award_id": "1R01GM145916-01A1", "title": "Multivalent protein-DNA nanostructures as synthetic blocking antibodies", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22262, "first_name": "KADIR", "last_name": "Aslan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2026-06-30", "award_amount": 296022, "principal_investigator": { "id": 27614, "first_name": "Nicholas", "last_name": "Stephanopoulos", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27615, "first_name": "Petr", "last_name": "Sulc", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 912, "ror": "", "name": "ARIZONA STATE UNIVERSITY-TEMPE CAMPUS", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "Protein-protein interactions (PPIs) drive countless processes in biology. The ability to block these interactions with high specificity is crucial for probing the basic science of these processes, as well as for developing imaging agents or novel therapeutics. However, most traditional molecules for blocking protein-protein interactions—like small molecules, peptides, or antibodies—rely on the precise targeting of the crucial interface or binding pocket, which can be difficult for some targets. Furthermore, none of these approaches can be easily tuned to match the valency or size of the target, and binding to patches on the protein not directly involved in PPIs can fail to block activity. Here, we propose to develop a nanoscale synthetic antibody (“nano-synbody”) consisting of a tunable DNA nanostructure bearing 2-3 peptide/protein ligands that can bind to distinct surfaces of a target protein and block its association with its partner through the steric bulk of the DNA structure. The individual peptide/protein binding agents will be derived from either known molecules, or found independently through methods like phage display. Critically, our method merges computational simulation—and in silico “evolution”—of these hybrid protein-DNA nano-synbodies, creating a library of structures and probing their association with the target. We aim to create a feedback loop, whereby the computational simulations yield candidate nano-synbodies that can be experimentally tested, further informing the next round of simulations. We will first apply this pipeline to a homo-trimeric nano-synbody against the SARS-CoV-2 spike protein trimer (Aim 1). This test bed will allow us to optimize the process and find a high-affinity blocking structure. Then, we will apply our method to nano-synbodies for blocking the assembly of fibrinogen into fibrin clots (Aim 2). The second Aim will involve phage display against fibrin to find novel binding agents, and thereby convert them into high-affinity hetero-trivalent structures. In both Aims, we will demonstrate the advantage of nano-structuring ligand presentation over simple oligomerization with flexible linkers. Taken together, our work will generate a new computational-experimental paradigm for the design of tunable, user-defined nanostructures that can present three or more peptides/proteins for binding to any protein, and blocking its association with its target. Crucially, our approach does not require binding directly to the interface, which should enable it to target a much larger range of proteins that may not be amenable to traditional approaches, large protein complexes, or mutants/variants of the targets that might escape single binding agents.", "keywords": [ "3-Dimensional", "ACE2", "Affinity", "Algorithms", "Antibodies", "Basic Science", "Beds", "Binding", "Binding Proteins", "Binding Sites", "Biological", "Biology", "Blocking Antibodies", "Coagulation Process", "Computer Simulation", "Cyclic Peptides", "DNA", "DNA Structure", "Disease", "Docking", "Evolution", "Feedback", "Fibrin", "Fibrinogen", "Geometry", "Grain", "Health", "Image", "Immobilization", "Individual", "Libraries", "Ligand Binding", "Ligands", "Light", "Literature", "Location", "Measures", "Membrane Proteins", "Methods", "Molecular", "Multiprotein Complexes", "Mutate", "Mutation", "Nanostructures", "Peptides", "Phage Display", "Polymers", "Positioning Attribute", "Process", "Protein Engineering", "Protein Hybridization", "Proteins", "Reporting", "SARS-CoV-2 inhibitor", "SARS-CoV-2 spike protein", "Series", "Shapes", "Site", "Specificity", "Structure", "Surface", "System", "Testing", "Translations", "Variant", "Work", "design", "flexibility", "hybrid protein", "imaging agent", "in silico", "monomer", "mutant", "nano", "nanobodies", "nanoscale", "neutralizing antibody", "next generation", "novel", "novel therapeutics", "polymerization", "polypeptide", "predictive test", "process optimization", "protein complex", "protein protein interaction", "receptor", "scaffold", "simulation", "small molecule", "synthetic antibodies", "targeted agent" ], "approved": true } }, { "type": "Grant", "id": "11743", "attributes": { "award_id": "1R13ES035640-01", "title": "ISES 2023 Annual Meeting", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22861, "first_name": "Daniel", "last_name": "Shaughnessy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2024-06-30", "award_amount": 12000, "principal_investigator": { "id": 27616, "first_name": "JONATHAN W", "last_name": "THORNBURG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2044, "ror": "", "name": "INTERNATIONAL SOCIETY/ EXPOSURE ANALYSIS", "address": "", "city": "", "state": "KS", "zip": "", "country": "United States", "approved": true }, "abstract": "The International Society of Exposure Science (ISES) is the premier international society devoted to bringing the full value of exposure science to research and decision-making to improve human health and the environment. This conference represents the most prominent and comprehensive gathering of environmental exposure scientists and environmental health professionals from academia, government, and organizations from around the world, reflecting the interdisciplinary nature of the field. The theme of the 33rd ISES Annual Meeting is “Connecting Communities and Science through Addressing Environmental Exposures.” The conference will specifically focus on new and emerging challenges for humans and the ecosystem. These challenges include extreme weather, natural disasters, wide application of pesticide, chemicals in consumer products, air pollution in both developed and developing countries, and multiple environmental stressors people are exposed, etc. Environmental exposures may affect human health and the ecosystem in a complex and non-linear way. Exposure and health issues also vary between local, regional, and global scales. Understanding the complex nature of environmental exposures, the health impacts, and relevant strategies and policies to improve environmental health requires the knowledge, analytical methods, and data collection tools developed from multiple disciplines and applied at different scales. Meeting topics include application of sensors in exposure assessment, citizen science and community-engaged research, climate change impacts on human exposure, COVID-19, vulnerabilities in environmental exposure and health, new and emerging environmental exposures, exposure data to policy action and impacts of public health policy, multiple exposures and interactions, risk communication, statistical methods in exposure science and epidemiology, and technology/sensors. There will be an added focus on environmental justice and community engaged research as it relates to the field of exposure science. The 33rd ISES annual conference will be held in Chicago, IL from August 27-31, 2023 and will continue the success of previous meetings. The meeting offers four and half days of cross- disciplinary presentations and discussions of new research and methods of international, national, and regional significance and facilitates the exchange of information and ideas among exposure science and environmental health scientists from academia, government agencies, non-profit organizations, and industry. Conference attendance is between 500 to 700 participants principally from North America and Europe. ISES has encouraged attendance of students and new researchers, as well as of investigators from low- and middle-income countries over the last 5 years resulting in an average of 15% increase in the number of attendees. This proposal will support the representation of students and new researchers from underrepresented backgrounds as well as provide an opportunity for participation of community members, hence enhancing member diversity, promoting the global development of exposure science, and fostering collaborations and information exchange both nationally and internationally.", "keywords": [ "Academia", "Address", "Affect", "Africa", "Air", "Air Pollution", "Asia", "Australia", "Award", "Biological", "COVID-19", "Chemicals", "Chicago", "Collaborations", "Communication", "Communities", "Community Participation", "Complex", "Country", "Data", "Data Collection", "Decision Making", "Developing Countries", "Development", "Discipline", "Disparity", "Ecosystem", "Education", "Environment", "Environmental Epidemiology", "Environmental Exposure", "Environmental Health", "Environmental Impact", "Environmental Policy", "Environmental Pollution", "Epidemiology", "Europe", "Event", "Exposure to", "Faculty", "Financial Support", "Food", "Fostering", "Funding", "Goals", "Government", "Government Agencies", "Health", "Health Policy", "Health Professional", "Human", "Industry", "International", "Knowledge", "Link", "Mentors", "Methodology", "Methods", "Names", "Natural Disasters", "Nature", "Noise", "Nonprofit Organizations", "North America", "Oceania", "Oral", "Participant", "Peer Review", "Persons", "Pesticides", "Policies", "Policy Making", "Public Health", "Radiation", "Research", "Research Methodology", "Research Personnel", "Resources", "Risk", "Scholarship", "Science", "Scientist", "Societies", "South America", "Statistical Methods", "Students", "Technology", "Training", "Translational Research", "Travel", "Water", "analytical method", "citizen science", "climate change", "community based participatory research", "community engaged research", "consumer product", "environmental agent", "environmental justice", "environmental stressor", "exposed human population", "extreme weather", "improved", "low and middle-income countries", "low income country", "meetings", "member", "new technology", "next generation", "pathogen", "posters", "sensor", "success", "successful intervention", "symposium", "tool" ], "approved": true } }, { "type": "Grant", "id": "11744", "attributes": { "award_id": "1R01NS129407-01A1", "title": "Cognitive sequelae of cerebrovascular and gut dysfunction in post-acute COVID-19 syndrome.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 27617, "first_name": "BARBARA P", "last_name": "Karp", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2028-05-31", "award_amount": 737345, "principal_investigator": { "id": 27618, "first_name": "Andrei A", "last_name": "Vakhtin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2045, "ror": "", "name": "LOVELACE BIOMEDICAL RESEARCH INSTITUTE", "address": "", "city": "", "state": "NM", "zip": "", "country": "United States", "approved": true }, "abstract": "ABSTRACT: Approximately one third of non-hospitalized coronavirus disease of 2019 (COVID-19) patients report chronic symptoms after recovering from the acute stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some of the most persistent and common complaints of this post-acute COVID-19 syndrome (PACS) are cognitive in nature, described subjectively as “brain fog” and also objectively measured as deficits in executive function, working memory, attention, processing speed. The mechanisms of these chronic cognitive sequelae are currently not understood. Most studies to-date have focused on direct SARS-CoV-2 infection of the brain; however, while direct viral brain infection is plausible in acute cases of severe and fatal COVID-19, it is of interest to examine indirect mechanisms of chronic cognitive dysfunction that follow mild and asymptomatic disease cases. SARS-CoV-2 inflicts damage to cerebral blood vessels and the intestinal wall by binding to angiotensin-converting enzyme 2 (ACE2) receptors and also by producing high levels of systemic cytokines, compromising the brain’s neurovascular unit and degrading the intestinal barrier, potentially increasing the permeability of both to harmful substances. Such substances are hypothesized to be produced by pathogenic microbiota in the gut that, given the profound effects COVID-19 has on the gastrointestinal system, may flourish via intestinal dysbiosis. COVID-19 may therefore create a scenario in which neurotoxic and neuroinflammatory substances readily proliferate from the gut lumen and encounter a weakened neurovascular unit, gaining access to the brain and subsequently producing cognitive deficits. We intend to examine such effects of SARS-CoV-2 in PACS patients longitudinally over the course of 3 study visits (baseline, 4 months, and 8 months). The impairments of cerebrovascular function and intestinal barrier, as well as their effects on cognitive symptomology, will be examined in 80 former COVID-19 patients who recovered from non-hospitalized acute phases of COVID-19, yet report persistent cognitive symptoms (PACS+). These patients will be compared with 80 former similar COVID-19 patients without such symptoms (PACS-). Forty healthy control participants will also be recruited to establish general neurovascular, intestinal, and cognitive effects of COVID-19 history. Cerebrovascular function will be quantified via innovative functional magnetic resonance imaging of cerebrovascular reactivity (CVR) to respiration of CO2 gas, while the intestinal barrier will be assessed via concentrations of intestinal wall biomarkers in blood plasma such as fatty acid-binding protein 2 (FABP-2) and zonulin. Gut dysbiosis will be established via lactulose breath testing, and levels of subsequently produced and systemically released lipopolysaccharide (LPS), peptidoglycan (PGN) and pro-inflammatory cytokines will also be quantified. Impairments in the neurovascular unit and intestinal barrier in the context of gut dysbiosis are expected to be associated with greater cognitive deficits in PACS+ patients. This work may reveal immediate recourses for resolving PACS cognitive effects via existing treatments for vascular dysfunction and gut health.", "keywords": [ "2019-nCoV", "ACE2", "Acute", "Adult", "Affect", "Area", "Attention", "Autopsy", "Binding", "Biological Markers", "Brain", "Breath Tests", "COVID-19", "COVID-19 impact", "COVID-19 mortality", "COVID-19 pandemic effects", "COVID-19 patient", "Carbon Dioxide", "Cerebrovascular system", "Chronic", "Clinical", "Cognition", "Cognition Disorders", "Cognitive", "Cognitive deficits", "Color", "Data", "Disease", "Encephalitis", "Endothelium", "Endotoxins", "Etiology", "Extramural Activities", "Functional Magnetic Resonance Imaging", "Functional disorder", "Funding", "Gases", "Gastroenterology", "Glial Fibrillary Acidic Protein", "Grant", "Health", "Impaired cognition", "Impairment", "Individual", "Infection", "Infiltration", "Inflammatory", "Internal Medicine", "Intervention", "Intestines", "Lactulose", "Left", "Lipopolysaccharides", "Long COVID", "Measures", "Modeling", "Nature", "Neurobehavioral Manifestations", "Neuropsychology", "Participant", "Pathogenesis", "Pathogenicity", "Pathologic", "Pathway interactions", "Patients", "Peptidoglycan", "Permeability", "Phase", "Physiological", "Plasma", "Proliferating", "Recording of previous events", "Recovery", "Reporting", "Research", "Research Personnel", "Respiration", "Respiratory Signs and Symptoms", "Role", "SARS-CoV-2 infection", "Short-Term Memory", "Smooth Muscle Myocytes", "Solid", "Statistical Data Interpretation", "Structure", "Symptoms", "System", "Text", "Time", "Toxin", "Vascular Diseases", "Viral", "Virus", "Visit", "Work", "acronyms", "brain fog", "cerebrovascular", "cerebrovascular imaging", "cytokine", "cytokine release syndrome", "dysbiosis", "executive function", "experience", "fatty acid-binding proteins", "gastrointestinal system", "gut dysbiosis", "gut health", "gut microbiota", "gut-brain axis", "innovation", "inter-institutional", "interest", "intestinal barrier", "intestinal epithelium", "microbiota", "multidisciplinary", "multimodal neuroimaging", "multimodality", "neuroimaging", "neuroinflammation", "neuropathology", "neurotoxic", "neurovascular", "neurovascular unit", "novel", "persistent symptom", "precision medicine", "processing speed", "public health emergency", "receptor", "recruit", "secondary analysis", "zonulin" ], "approved": true } }, { "type": "Grant", "id": "11745", "attributes": { "award_id": "1R34MH130639-01A1", "title": "Expanding minority youth access to evidence-based care: A pilot effectiveness trial of a digital mental health intervention", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 11081, "first_name": "Mary", "last_name": "Rooney", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2026-06-30", "award_amount": 271895, "principal_investigator": { "id": 27619, "first_name": "ERUM", "last_name": "NADEEM", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27620, "first_name": "Anna Robinson", "last_name": "Van Meter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 832, "ror": "", "name": "NEW YORK UNIVERSITY SCHOOL OF MEDICINE", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The prevalence of anxiety and depression are high among adolescents. COVID-19-related stressors have increases rates of internalizing disorders and risk for suicide, especially among ethnic minority adolescents who have been disproportionately affected by the pandemic. Although evidence-based interventions are effective, the vast majority ethnic minority adolescents do not access any MH care. School-based MH services can address common barriers to care such as cost and transportation. However, even with access to school- based MH services, capacity can be highly limited in schools, and some adolescents may be reticent to seek services at school due to concerns about privacy, judgment, and academic disruption. Innovative approaches to provide accessible, low-cost, evidence-based MH care to minority youth are urgently needed. Technology creates an opportunity to treat youth in need of MH services and could expand the reach of school health services. Despite the potential impact of digital care, to date there are no studies examining whether digital mental health interventions improve service access for vulnerable youth served by school-based mental health services. Consistent with NIMH Notice of Information MH-18-031 designating digital health technology as a priority, this application proposes to determine the feasibility and acceptability of delivering SilverCloud, a clinician-guided, empirically-supported, app-based, CBT program to vulnerable adolescents through school- based health centers (SBHCs). In contrast to most MH apps, SilverCloud has demonstrated strong engagement and medium-to-large effect sizes. Its features, including personalized feedback, stories from relatable peers, and routine outcome assessment, directly promote engagement. This would be the first trial to evaluate SilverCloud as a school-based intervention and refine it to meet the needs of low income, ethnic/racial minority youth. We propose a four-phase study conducted at two diverse, public schools in Brooklyn. In Phase I, participants who endorse internalizing symptoms (n=20) during routine MH screening at the SBHC will participate in an open trial of SilverCloud. In Phase II, open trial participants will provide feedback that will be used to refine the SilverCloud program. In Phase III participants will be screened (PHQ-9/GAD-7). Those who endorse symptoms will be randomized (N=100) to SilverCloud or treatment as usual (TAU). Outcomes will be evaluated each semester. In Phase IV, participant and stakeholder feedback will be collected systematically to further inform program adaptations and implementation strategy refinement for a large effectiveness trial. Primary aims are to establish the feasibility, acceptability, and preliminary effectiveness of SilverCloud among minority youth served through SBHCs and to examine whether SilverCloud changes engagement (i.e., initiation, dose) and clinical (i.e., emotion regulation, negative cognitions, coping skills, behavioral activation) targets, and whether changes are associated with clinical benefit (i.e., reduction in depression and anxiety).", "keywords": [ "Academy", "Address", "Adolescent", "Adolescent Psychiatry", "Adult", "Affect", "American", "Anxiety", "Behavioral", "Black race", "COVID-19", "Caring", "Child Psychiatry", "Clinical", "Cognition", "Communities", "Consent", "Coping Skills", "Disease", "Dose", "Economics", "Education", "Effectiveness", "Ethnic Origin", "Evidence based intervention", "Exhibits", "Exposure to", "Family", "Feedback", "Feeling suicidal", "Focus Groups", "Fright", "Health", "Health Services Accessibility", "Health Technology", "Hybrids", "Immigrant family", "Improve Access", "Intervention", "Interview", "Judgment", "Latinx", "Low income", "Mental Depression", "Mental Health", "Mental Health Services", "Mental disorders", "Moods", "National Health Services", "National Institute of Mental Health", "Outcome", "Outcome Assessment", "Parents", "Participant", "Pediatrics", "Persons", "Phase", "Population", "Prevalence", "Privacy", "Public Health", "Randomized", "Randomized Controlled Trials", "Research", "School Health Services", "Schools", "Services", "Stress", "Students", "Suicide attempt", "Surgeon", "Symptoms", "Technology", "Testing", "Transportation", "Youth", "acceptability and feasibility", "anxiety symptoms", "barrier to care", "cost", "depressive symptoms", "digital", "digital health", "digital healthcare", "digital intervention", "digital mental health", "disorder risk", "effective intervention", "effectiveness trial", "effectiveness/implementation trial", "emotion regulation", "ethnic minority", "evidence base", "experience", "functional improvement", "high school", "implementation strategy", "improved", "innovation", "minority children", "pandemic disease", "peer", "programs", "racial disparity", "racial minority", "reduce symptoms", "screening", "social stigma", "stressor", "substance use", "suicidal risk", "suicide rate", "tool", "trauma exposure", "treatment as usual", "university student", "vulnerable adolescent" ], "approved": true } }, { "type": "Grant", "id": "11746", "attributes": { "award_id": "1U18FD008031-01", "title": "Molecular and serological surveillance of SARS-CoV-2 in companion and food animals, USA", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 26272, "first_name": "Megan", "last_name": "Miller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2024-06-30", "award_amount": 33715, "principal_investigator": { "id": 27621, "first_name": "Chengming", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2027, "ror": "", "name": "AUBURN UNIVERSITY AT AUBURN", "address": "", "city": "", "state": "AL", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Abstract/Summary Molecular and serological surveillance of SARS-CoV-2 in companion and food animals, USA Monitoring SARS-CoV-2 infections in animals is crucial for better understanding the virus and its potential for transmission between species. The virus has already been shown to infect a range of animals, including minks, dogs, and cats. By monitoring animal infections, potential reservoirs of the virus can be identified and new strains that may be more transmissible or virulent can be prevented. Additionally, monitoring animal infections ensures the safety of both animal and human populations by identifying and controlling infections in animals. In this study, we will perform PCR and ELISAs to detect SARS-CoV-2 virus and antibodies in nationwide collected dog samples (n=800), cat samples (n=800), and in horse (n=200) and cattle (n=200) samples from Alabama. SARS-CoV-2 Reverse- Transcription FRET-PCR will be performed to detect the virus, followed by DNA sequencing and whole-genome sequencing. The ID Screen® SARS-CoV-2 Double Antigen ELISA and SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT) will be used to detect antibodies against SARS-CoV-2 infection, and positive and questionable samples will be sent to the United States Department of Agriculture (USDA) National Veterinary Services Laboratories (NVSL) for SARS-CoV-2 virus neutralization tests to confirm results. Monitoring animal populations for SARS-CoV-2 infections is essential to prevent the spread of the virus to humans and identify potential reservoirs of the virus. This study will also help to understand the epidemiology of SARS-CoV-2 in dogs, cats, and horses, as well as food animals in the USA.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11747", "attributes": { "award_id": "1U18FD008009-01", "title": "Vet-LIRN Network Capacity Building for SARS-CoV-2: equipment for analysis of NGS library and data", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 26272, "first_name": "Megan", "last_name": "Miller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2024-06-30", "award_amount": 52822, "principal_investigator": { "id": 24756, "first_name": "Leyi", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1040, "ror": "", "name": "UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1040, "ror": "", "name": "UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "The University of Illinois (UI) Veterinary Diagnostic Laboratory (VDL) is a full service, AAVLD accredited, all species, reference laboratory. UI VDL is a member of the VET-LIRN. As of Feb 17, 2023, UI VDL has tested 3,287 samples for SARS-CoV-2 and 350 samples of zoo animals in 13 different zoos were tested positive. Next- generation sequencing (NGS) is very useful in case investigation of SARS-CoV-2 in the veterinary diagnostic laboratory and could be affected by many factors including selection of sequencing methods, sequencing library quality, amount of viral genome, sample quality, sample pooling, and bioinformatics analysis. New equipment for analyzing both NGS library and big data will significantly increase our SARS-CoV-2 testing capacity and service quality for routine case diagnosis and surveillance coordinated by Vet-LIRN, thus enhancing Vet-LIRN network laboratory for SARS-CoV-2 testing.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "11748", "attributes": { "award_id": "1R01CA277738-01A1", "title": "A dyadic exercise approach to prevent declines in physical and mental health in couples during radiation treatment for cancer: a hybrid type I efficacy-implementation trial", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 27622, "first_name": "AMANDA MARIE", "last_name": "Acevedo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2028-06-30", "award_amount": 560335, "principal_investigator": { "id": 27623, "first_name": "KERRI M", "last_name": "WINTERS-STONE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 765, "ror": "https://ror.org/009avj582", "name": "Oregon Health & Science University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "Breast and prostate cancer are two of the most common and survivable cancers and most survivors of these cancers will be married when diagnosed. Compared to couples that aren't facing a chronic illness, both cancer survivors and their spouses suffer from poorer physical and mental health that leads higher morbidity and mortality. Since couples experience and navigate an illness together their health becomes intertwined, thus programs aimed at one member of the dyad ignore the interdependent nature of the couple. Exercise improves quality of life among cancer survivors; but, we were the first to adapt exercise to be a partnered activity that amplifies the dose of exercise and builds teamwork to improve dyadic outcomes (i.e., physical and mental health of patients and partners). We developed and piloted Exercising Together in prostate cancer survivors and their spouses long after his diagnosis. The pilot showed that six months of partnered exercise could improve physical and mental health in both partners as well as their intimate relationship. We believe the program would be most effective at mitigating the impact of newly diagnosed cancer and treatment on the physical and mental health of each partner if implemented much earlier in the point of care for patients. We have preliminary data on 10 couples who participated in an adapted version of Exercising Together during his radiation treatment for prostate cancer (6-8 weeks). The adapted program is much shorter (8 v. 24 wks.) than the original and is more focused on developing teamwork as a mechanism to amplify the benefits of exercise on dyadic outcomes. All couples completed the program and improved physical and mental health and their level of communication; however, we had no control group so we cannot be certain if the program is efficacious or not nor how long lasting the effects of the program might be. We now propose a Type I hybrid effectiveness-implementation trial of Exercising Together adapted for the radiation oncology setting. This design allows us to formally test the efficacy of a clinic- based version of Exercising Together using a randomized controlled design, a larger sample, a broader set of outcomes, and a follow-up period. We will also examine putative dyadic mechanisms to explain how our intervention improves dyadic health. At the same time, we will gather critical information from multiple stakeholders to inform future implementation approaches to integrate Exercising Together into the care plan for cancer patients. We propose a randomized controlled Phase II trial in 200 couples who will be randomly assigned to participate in an 8-week program of Exercising Together at the start of his/her radiation therapy or to a usual care control group that receives standard exercise guidance and receipt of a video of the couples program at the end of participation. Couples are tested at baseline, post-intervention (2 mos.), and 4- and 6-mos. follow up. Based on adaptations in other trials developed during COVID19, exercise training and assessments will be delivered through remote technology, which allows us to better diversity the sample and widen the scalability of the program.", "keywords": [ "Address", "Administrator", "Aftercare", "Anxiety", "Biometry", "Breast Cancer survivor", "COVID-19", "Cancer Patient", "Cancer Survivor", "Caring", "Categories", "Cessation of life", "Chronic Disease", "Clinic", "Clinical", "Collaborations", "Communication", "Control Groups", "Couples", "Data", "Diagnosis", "Dose", "Educational process of instructing", "Emotional", "Exercise", "Face", "Fatigue", "Feasibility Studies", "General Population", "Health", "Health Personnel", "Heart Diseases", "Hybrids", "Hypertension", "Individual", "Inflammation", "Insulin Resistance", "Intervention", "Malignant Neoplasms", "Malignant neoplasm of prostate", "Marriage", "Mental Depression", "Mental Health", "Metabolic syndrome", "Methods", "Morbidity - disease rate", "Nature", "Newly Diagnosed", "Obesity", "Oncology", "Outcome", "Pathway interactions", "Patient Care", "Patients", "Physical Function", "Physical Rehabilitation", "Play", "Process", "Process Measure", "Prostate Cancer therapy", "Psyche structure", "Publications", "Qualitative Methods", "Quality of life", "Radiation Oncology", "Radiation therapy", "Randomized", "Recommendation", "Reporting", "Role", "Sampling", "Science", "Self Efficacy", "Sleep", "Social support", "Spouses", "Supportive care", "Survivors", "Technology", "Testing", "Time", "Training", "Woman", "Work", "acceptability and feasibility", "adverse outcome", "biopsychosocial", "cancer care", "cancer diagnosis", "cancer therapy", "clinical care", "clinical practice", "cost", "design", "disability", "effectiveness/implementation study", "effectiveness/implementation trial", "efficacy testing", "efficacy/implementation trial", "exercise program", "exercise training", "experience", "falls", "fitness", "follow-up", "fortification", "future implementation", "high risk", "implementation science", "implementation study", "improved", "information gathering", "innovation", "intimate behavior", "malignant breast neoplasm", "member", "men", "mortality", "multidisciplinary", "phase II trial", "physical conditioning", "point of care", "post intervention", "prevent", "programs", "prostate cancer survivors", "psychosocial", "randomized controlled design", "remote delivery", "satisfaction", "sex", "symptom management", "theories", "treatment as usual", "usual care arm" ], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1424, "count": 14236 } } }