Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=approved" }, "data": [ { "type": "Grant", "id": "12331", "attributes": { "award_id": "2R56AG038961-11A1", "title": "Assessment of ultrasound-facilitated neurotherapeutics in Alzheimer's disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 28243, "first_name": "PAUL G", "last_name": "GROTHAUS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-21", "end_date": "2025-05-31", "award_amount": 798155, "principal_investigator": { "id": 28244, "first_name": "Elisa E.", "last_name": "Konofagou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Alzheimer’s disease (AD) kills 1 in 3 seniors (more than breast and prostate cancer combined), increased by 16% during the covid-19 pandemic in 2020 and is the costliest condition with an expected $355 billion in healthcare costs in 2021 and $1.1 trillion in 2050. Although some effective treatments are available, Alzheimer’s remains severely undertreated with several pharmacological compounds failing in clinical trials and/or practice over the past three decades. Focused Ultrasound (FUS), in conjunction with microbubbles, remains the sole technique that can induce localized blood-brain barrier (BBB) opening noninvasively, selectively and safely. Despite the fact that the technology was initially intended to open the BBB for drug delivery, our group was the first to report that BBB opening alone can lead to cognitive amelioration in primates. The safe BBB opening enabled by FUS can lead to an immune cascade that is in turn correlated with reduction of cognitive deficits and pathology. Prior to our studies reported herein, the immunotherapeutic potential of the FUS-mediated BBB opening was unknown. in this renewal study, we aim to determine 1) the currently unknown neuroprotective and immunotherapeutic mechanisms of FUS- mediated BBB opening as well as the duration of the aforementioned effects in multi-session BBB opening, 2) link cognitive improvement and/or immune response with synaptic density increase, 3) optimize the clinical FUS system for accurate hippocampal targeting in humans, 3) assess neuroprotection efficacy in asymptomatic AD subjects and 4) assess immunotherapeutic efficacy in symptomatic AD subjects. The underlying hypothesis is thus that FUS-mediated BBB opening alone leads to neuroprotective and immunotherapeutic with sustained mnemonic amelioration in AD. The multi-disciplinary team encompasses all critical specialty areas involved, such as ultrasound engineering as well as MRI, PET and AD pathology, neuroimmunology, cognitive and memory testing and mouse model development as they pertain to neuroscience and neurology. Following the proposed studies, this entirely noninvasive and cost efficient BBB opening technology will be translated in the clinical routine so as to harness its clinical potential in the treatment of Alzheimer’s.", "keywords": [ "3-Dimensional", "3xTg-AD mouse", "Aftercare", "Age", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease model", "Alzheimer&apos", "s disease pathology", "Alzheimer&apos", "s disease patient", "Amyloid", "Amyloid beta-Protein", "Area", "Astrocytes", "Behavioral", "Blood - brain barrier anatomy", "Blood Tests", "Brain", "COVID-19 pandemic", "Central Nervous System Diseases", "Clinical", "Clinical Trials", "Code", "Cognition", "Cognitive", "Cognitive deficits", "Dependence", "Drug Delivery Systems", "Engineering", "Episodic memory", "Focused Ultrasound", "Funding", "Health Care Costs", "Hippocampus", "Human", "Immune", "Immune response", "Immunotherapeutic agent", "Immunotherapy", "Infrastructure", "Journals", "Link", "Longitudinal Studies", "Macrophage", "Magnetic Resonance Imaging", "Malignant neoplasm of prostate", "Maps", "Mediating", "Memory", "Memory impairment", "Microbubbles", "Microglia", "Monitor", "Mus", "National Institute on Aging", "Neurodegenerative Disorders", "Neurology", "Neuronavigation", "Neurosciences", "Onset of illness", "Outcome", "Pathology", "Peer Review", "Peripheral", "Pharmacological Treatment", "Phenotype", "Positron-Emission Tomography", "Prefrontal Cortex", "Primates", "Progress Reports", "Publications", "Reporting", "Short-Term Memory", "Site", "Synapses", "System", "Techniques", "Technology", "Testing", "Therapeutic", "Therapeutic Effect", "Time", "Translating", "Translations", "asymptomatic Alzheimer&apos", "s disease", "clinical practice", "clinical translation", "cohort", "cost efficient", "density", "effective therapy", "immune activation", "improved", "malignant breast neoplasm", "medical specialties", "model development", "mouse model", "multidisciplinary", "nervous system disorder", "neuroimmunology", "neuroprotection", "nonhuman primate", "patient safety", "pharmacologic", "recruit", "response", "sex", "simulation", "tau Proteins", "timeline", "transcriptomics", "ultrasound" ], "approved": true } }, { "type": "Grant", "id": "12332", "attributes": { "award_id": "1U01IP001171-01", "title": "RFA-IP-22-001 - Burden and sequelae of influenza, SARS-CoV-2 and other respiratory viruses associated Severe Acute Respiratory Infections among Indian adult population aged 18-60yrs", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-09-30", "end_date": "2027-09-29", "award_amount": 1000000, "principal_investigator": { "id": 28245, "first_name": "Anand", "last_name": "Krishnan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2084, "ror": "", "name": "ALL-INDIA INSTITUTE OF MEDICAL SCIENCES", "address": "", "city": "", "state": "", "zip": "", "country": "INDIA", "approved": true }, "abstract": "As a logical extension of the work done by the team at the All India Institute of Medical Science, New Delhi, this work will expand to include more geographically diverse sites and address adults who have not been adequately studied but who due to their productivity can dis-appropriately contribute to the overall economic burden. The proposal intends to execute a series of inter-related activities to support evidence-based policy development to address Influenza and SARSCo-V2 infection in working adult population of India. The specific objectives are to estimate the incidence and treatment cost of Influenza and SARS-CoV-2 associated Severe Acute Respiratory Infections (SARI) among adults aged 18-60 years and characterize the detected viruses; to estimate the incidence of short and long-term sequelae of Influenza and SARS-CoV-2 associated SARI and risk of re-infection; to assess vaccine hesitancy and uptake among health care workers and estimate the effectiveness of influenza and COVID-19 vaccines against serious illness and finally, conduct capacity building initiatives for health professionals and advocate for public health approach for prevention and control of influenza and COVID-19 disease in India among key stakeholders. This will be done by setting up Indian National SARI Platform for Influenza and other Respiratory Pathogens (INSPIRES) a multi-centric network of public tertiary hospitals with three components – hospital-based SARI Registry with a cohort of Influenza or COVID-19 patients with a linked community site and a cohort of healthcare workers. The platform will consist of geographically spread 10-12 medical colleges which routinely admit and manage SARI cases. The patients with severe acute respiratory infection (SARI) admitted and testing positive for identified pathogens i.e., influenza and SARS CoV-2. The community-based SARI surveillance to be conducted in the catchment area of the hospitals will estimate SARI incidence rates. Combining the two will provide agent- specific SARI rates for each participating site. A cohort of influenza and SARS CoV-2 positive patients identified above will be followed for two years after enrolment to look at pulmonary, cardiac, cognition, functional status and quality of life parameters. A cohort of health care workers in the study hospitals will be followed up for the duration of the study. After a baseline assessment of their vaccine uptake and hesitancy, they will be sensitized to the need for vaccination and offered free vaccines (both influenza and COVID-19) as per the hospital policy. All participants will be followed up for a period of two years for development of symptomatic Influenza or SARS CoV2 infection. A Respiratory viruses Resource Centre will be set up at AIIMS New Delhi to prepae training and advocacy materials for liaising with a diverse set of stakeholders ranging from general population, healthcare professionals to policy makers.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12333", "attributes": { "award_id": "1S10OD034213-01", "title": "Metabolic/gas exchange system", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 25507, "first_name": "Xiang-Ning", "last_name": "Li", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2024-09-14", "award_amount": 161169, "principal_investigator": { "id": 28246, "first_name": "KENNETH K", "last_name": "KWONG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "This application requests funding to purchase a Metabolic/Gas Exchange system. The state-of- the-art Metabolic Gas Exchange system is the only system with accessories made compatible with magnetic resonance imaging (MRI) to acquire a wide range of breath-by-breath gas exchange and pulmonary function parameters. In addition, a set of comprehensive vital monitoring tools will be equipped to ensure the safety of the research subjects and the needs of physiological recordings in different clinical and hardware/software development research at the Martinos Center, across different departments at MGH, as well as different institutions in the Boston area. The proposed Metabolic/Gas Exchange system is especially important to ensure the continuity of the existing funded projects and the synergistic research in the future. The system not only serves as a replacement of the existing equipment constructed with separate pieces of outdated devices that are nearly worn out but also provides a wider opportunity for synergizing research in the study of brain activity in association with pulmonary function and gas exchange. For example, one major area in the near future is mechanistic and clinical research for the potential upcoming rehabilitation pandemic of long COVID, which involves studying the interaction between the brain, pulmonary system, and cardiovascular system. The proposed Metabolic/Gas Exchange system will be located within the Athinoula A. Martinos Center for Biomedical Imaging, MGH. The Martinos Center has a renowned biomedical imaging program, consistently producing successes with imaging modalities such as MRI, magnetoencephalography (MEG), positron emission tomography (PET), and optical imaging. The proposed system will be fully utilized in the existing and future imaging research on this successful imaging platform for the users at Martinos Center and the other institutions in Boston.", "keywords": [ "Area", "Boston", "Brain", "Cardiovascular system", "Clinical", "Clinical Research", "Devices", "Diagnostic Imaging Program", "Ensure", "Equipment", "Funding", "Future", "Gases", "Image", "Institution", "Long COVID", "Lung", "Magnetic Resonance Imaging", "Magnetoencephalography", "Metabolic", "Monitor", "Physiological", "Positron-Emission Tomography", "Rehabilitation therapy", "Request for Applications", "Research", "Research Subjects", "Safety", "System", "biomedical imaging", "imaging modality", "imaging platform", "optical imaging", "pandemic disease", "pulmonary function", "research and development", "software development", "success", "tool" ], "approved": true } }, { "type": "Grant", "id": "12334", "attributes": { "award_id": "1R01DA055851-01A1", "title": "UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 21283, "first_name": "JULIA BETH", "last_name": "Zur", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-07-31", "award_amount": 979886, "principal_investigator": { "id": 28247, "first_name": "Stephen E", "last_name": "Lankenau", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28248, "first_name": "David Gary", "last_name": "Schwartz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 377, "ror": "https://ror.org/04bdffz58", "name": "Drexel University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Reducing overdose mortality immediately and long-term is a top public health priority as the overdose epidemic in the U.S. continues to worsen. The COVID-19 pandemic, which began hitting the U.S. in early 2020, has exacerbated the overdose crisis - particularly among African Americans and Latinxs. Opioid overdose deaths, which accounted for the most overdose deaths in 2020, continue to drive the epidemic. Overdose deaths linked to synthetic opioids, such as illicitly manufactured fentanyl, have increased significantly and comprised most of the opioid-related deaths in 2020. Despite increasing availability and acceptability of naloxone among laypersons, opioid overdose deaths remain catastrophically high in communities across the U.S. The UnityPhilly smartphone app was developed in 2018-19 alongside several community-based organizations as a public health intervention in response to the opioid overdose crisis in Philadelphia, which has the most acute overdose epidemic among large cities in the U.S. UnityPhilly automatically connects bystanders and victims of opioid overdose with nearby community members who can respond immediately with naloxone. The objective of this proposal, following a successful feasibility study (R34) and clear evidence of overdose reversal supported by UnityPhilly, is to create an easy-to-use, effective, sustainable, and scalable smartphone app to be deployed across the city of Philadelphia. This objective will be achieved by studying subgroups of people equipped with naloxone and UnityPhilly (n=450) and disseminating UnityPhilly to 3,000 citizen volunteers for everyday use to respond to opioid overdose emergencies. The long-term goal of this research is to create a scalable app that can be disseminated to communities across the U.S. experiencing high levels of opioid overdose death. The rationale for this study is that expanding the availability of the UnityPhilly app to laypersons citywide will increase the speed and delivery of naloxone to opioid overdose events across Philadelphia while laying the groundwork for scalability and broader national uptake. Our goals will be achieved with three specific aims: 1) Redevelop UnityPhilly to ensure ease of use; 2) Assess differences in the effectiveness of UnityPhilly across varied urban environments and participant profiles; and 3) Build and study a sustainable environment for UnityPhilly to expand city-wide. This 5-year study will have significant impact by providing actionable evidence regarding the effectiveness of an app-based naloxone intervention to scale up for nationwide use. The study will be conducted in partnership with long-standing community-based organizations to ensure usability and acceptability. This intervention is highly significant since it directly addresses one of the most significant public health problems in the U.S. – the opioid overdose epidemic – which is worsening due to the effects of COVID-19. This intervention is highly innovative as it improves upon a previous developed successful mobile phone app and expands its use to a broader population of users in a large city most impacted by the opioid crisis.", "keywords": [ "Acute", "Address", "Adoption", "African American population", "COVID-19 impact", "COVID-19 pandemic", "Cessation of life", "Cities", "Communities", "Disease", "Effectiveness", "Emergency Situation", "Enrollment", "Ensure", "Environment", "Epidemic", "Equity", "Event", "Family member", "Feasibility Studies", "Fentanyl", "Goals", "Government Agencies", "Health", "Heroin", "Intervention", "Latinx", "Link", "Local Government", "Maintenance", "Medical", "Mission", "Modeling", "Naloxone", "Neighborhoods", "Outcome", "Outcome Measure", "Overdose", "Overdose reduction", "Overdose reversal", "Participant", "Pathway interactions", "Pattern", "Persons", "Philadelphia", "Population", "Process", "Psyche structure", "Public Health", "Reach Effectiveness Adoption Implementation and Maintenance", "Recovery", "Research", "Signal Transduction", "Speed", "Subgroup", "United States National Institutes of Health", "behavioral study", "community organizations", "design", "experience", "improved", "innovation", "insight", "manufacture", "member", "mortality", "opioid epidemic", "opioid misuse", "opioid mortality", "opioid overdose", "opioid use", "overdose death", "overdose risk", "pilot test", "prescription opioid", "public health intervention", "public health priorities", "response", "scale up", "smartphone application", "synthetic opioid", "uptake", "urban setting", "usability", "volunteer", "willingness" ], "approved": true } }, { "type": "Grant", "id": "12335", "attributes": { "award_id": "1R03OH012445-01A1", "title": "COVID-19 and Nail Salon Workers: Taking Stock of the Pandemic's Impact on Occupational Health and Safety", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 24486, "first_name": "Maria", "last_name": "Lioce", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2025-09-29", "award_amount": 76824, "principal_investigator": { "id": 28249, "first_name": "Aurora B", "last_name": "Le", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28250, "first_name": "Marie-Anne Sanon", "last_name": "Rosemberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 770, "ror": "", "name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "PROJECT SUMMARY/ABSTRACT: The 400,000 nail salon workers (NSW) in the U.S.—primarily immigrant women in their prime reproductive years—are part of a $10 billion small business industry that is understudied and hard-to-reach. NSWs are emblematic of low-wage, underinsured, immigrant women in the workforce who are invisible in the communities they serve. This overlooked worker population is continuously exposed to occupational hazards such as toxic chemicals, biological agents, poor ergonomics, and psychological stressors. The coronavirus pandemic (COVID-19) heightened not only the economic vulnerability of these workers but also exacerbated existing unaddressed occupational health and safety (OHS) issues. Pre- pandemic studies indicated NSWs expressed needs for training on product exposure and safety measures. Given COVID-19, workplace priorities have undoubtedly shifted as the focus may now be on job security, infection control, resource access, and mental health. In addition, NSWs are particularly at risk for COVID-19 infection given the close proximity needed to provide client services. Several recommendations have been published to guide employers’ methods to safeguard employees’ OHS during the pandemic. However, we do not know whether and to what extent nail salons owners are adopting and implementing those guidelines to protect their workers. Without a comprehensive understanding of established protective measures and whether and how NSW priorities have shifted in light of COVID-19, future interventions will be ill-equipped to meet their needs and effectively promote these workers’ health and wellbeing. This mixed-method sequential design study, guided by a community-engaged approach has the following Specific Aims: (1) Characterize the safety measures that nail salon owners have implemented during COVID-19 and changes in priorities; (2) Explore NSWs’ perceived OHS experiences and needs during COVID-19; and (3) Collaborate with NSWs and owners to develop, pilot, and validate a survey instrument informed by the literature and qualitative data from Aims 1 and 2. This proposal advances the missions of the NIOSH National Occupational Research Agenda (NORA) Services sector as well as the Healthy Work Design and Well-Being Cross-Sector as it will: 1) advance our assessment approach of OHS needs and changes, in light of the pandemic, among an understudied small business industry worker group; and 2) inform the design of a future evidence-based intervention. The main research-to-practice (r2p) contribution of this application is two-pronged: 1) the development of a targeted survey to improve understanding of the pandemic’s effects on NSWs OHS and other workers with similar types of characteristics (e.g., female, low-wage, underinsured, immigrant); and 2) establish and strengthen partnership and collaboration among the study team members and nail salon community. Intermediate outcomes include the potential for changes in NSW needs assessment methodology for occupational health researchers. In addition to the survey, outputs will include publications and conference proceedings.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12336", "attributes": { "award_id": "1R01AA030970-01", "title": "Using patient-level decision modeling to improve use of treatments for alcohol use disorder", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 27572, "first_name": "BRETT THOMAS", "last_name": "HAGMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2028-06-30", "award_amount": 683741, "principal_investigator": { "id": 28251, "first_name": "Phuc", "last_name": "Le", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1013, "ror": "", "name": "CLEVELAND CLINIC LERNER COM-CWRU", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "Alcohol use disorder (AUD), previously alcohol abuse and dependence, is a significant public health problem. In the US, excessive alcohol use is responsible for 93,000 deaths and 2.7 million years of potential life lost, at a cost of $250 billion annually. In 2012-13, the 12-month and life-time prevalence of AUD in US adults was 14% and 29%, respectively, increasing by more than 40% from a decade earlier. Since the Covid-19 pandemic, alcohol consumption has increased even more. Excessive alcohol consumption affects various bodily organs, leading to many health consequences. Fortunately, AUD is more treatable than commonly believed. Cognitive behavioral therapy, brief interventions, and motivational enhancement therapy are the most widely studied behavioral interventions and are similarly efficacious, while Alcoholics Anonymous (AA) is the most sought out mutual support group. Pharmacotherapy can be combined with behavioral interventions to increase success. However, treatments for AUD are underutilized. The misconception among patients and physicians that treatment is ineffective is an important obstacle to use. Another is the common view that treatment success requires total abstinence. In reality, recovery from AUD can include some heavy drinking, and AUD treatment can be effective. Expressing treatment effectiveness into long-term health benefits could help convince physicians to offer treatment and encourage patients to use it. However, randomized controlled trials (RCTs) alone cannot provide this information because they do not measure long-term health outcomes, nor do they compare all treatments head-to-head, making it difficult to choose among them. Simulation modeling offers a comprehensive approach to comparing treatments, but none of existing AUD models were designed to assess all treatments. We designed a decision aid (DA) describing treatment options, but it does not yet include estimates of long-term benefits due to lack of such data at the time of development. Project objective: To develop, validate, and apply a computer simulation model to inform policy makers, physicians, and patients of the lifetime benefit of treatments for AUD. Aim 1: Develop and validate a microsimulation model of the natural history of alcohol-associated complications accounting for the change in drinking behaviors and AUD status over time. Aim 2: Assess the comparative effectiveness of AUD treatments. Aim 3: Incorporate patient and provider feedback to assess the clarity, content, and acceptability of augmenting an existing DA with comparative effectiveness data. Impact: Our model will offer a better understanding of the expected benefit of AUD treatments and provide an innovative approach to decision modeling and treatment selection. By incorporating long-term effectiveness data into an existing DA, our study will provide physicians and patients with valuable evidence and a tool to support selection of optimal treatments, thereby helping to close the treatment gap. Ultimately, our project will address NIAAA’s research missions while improving the quality of life for tens of millions of US adults suffering from AUD.", "keywords": [ "Abstinence", "Accounting", "Acute", "Adult", "Affect", "Alcohol abuse", "Alcohol consumption", "Alcohol dependence", "Alcoholic Liver Diseases", "Alcoholics Anonymous", "Alcohols", "American", "American Psychiatric Association", "Baclofen", "Behavior Therapy", "COVID-19 pandemic", "Calibration", "Caring", "Cessation of life", "Chronic Disease", "Cognitive Therapy", "Computer Simulation", "Data", "Decision Aid", "Decision Modeling", "Development", "Disease model", "Disulfiram", "Effectiveness", "Feedback", "Head", "Health", "Health Benefit", "Heavy Drinking", "Injectable", "Intervention", "Interview", "Life", "Literature", "Liver diseases", "Mathematical Model Simulation", "Medical", "Mission", "Modeling", "Naltrexone", "National Institute on Alcohol Abuse and Alcoholism", "Natural History", "Oral", "Organ", "Outcome", "Patients", "Persons", "Pharmaceutical Preparations", "Pharmacotherapy", "Physicians", "Policy Maker", "Prevalence", "Provider", "Public Health", "Quality of life", "Randomized Controlled Trials", "Recommendation", "Recovery", "Reporting", "Research", "Selection for Treatments", "Severities", "Structure", "Support Groups", "System", "Time", "Treatment Effectiveness", "United States Food and Drug Administration", "acamprosate", "alcohol abuse therapy", "alcohol measurement", "alcohol use disorder", "behavioral study", "brief intervention", "comparative effectiveness", "compare effectiveness", "cost", "design", "drinking", "drinking behavior", "follow-up", "gabapentin", "improved", "innovation", "liver transplantation", "models and simulation", "motivational enhancement therapy", "optimal treatments", "prevent", "programs", "psychosocial", "shared decision making", "success", "tool", "topiramate", "treatment comparison", "trial comparing" ], "approved": true } }, { "type": "Grant", "id": "12337", "attributes": { "award_id": "1U01DK136523-01", "title": "Evaluation of Novel Technologies to Improve Clinical Management of Celiac Disease: The GLUTECH Trial", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 23868, "first_name": "Aynur", "last_name": "Unalp-Arida", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2028-06-30", "award_amount": 1288211, "principal_investigator": { "id": 24601, "first_name": "Benjamin", "last_name": "Lebwohl", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24602, "first_name": "Randi L.", "last_name": "Wolf", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "The proposed project addresses the need for a rigorous trial to test the effectiveness of novel gluten detection technologies as an adjunct to telemedicine to manage celiac disease in adults. Celiac disease affects about 1% of the United States (U.S.) population and seroprevalence has increased up to 5-fold in the U.S. since the 1950’s, with diagnosis rates continuing to rise. Morbidity can be severe and includes anemia, infertility, osteoporosis, and malignancies, which can increase all-cause mortality. The only proven therapy is a strict gluten-free diet, the management of which can be extremely challenging and has been linked to diminished quality of life, including anxiety, depression, and fatigue. Despite the recommendation to see a dietitian regularly, many with celiac disease do not see one at all or have only a single session immediately post-diagnosis. The COVID-19 pandemic has catalyzed the rapid adoption of telemedicine in gastroenterology and can facilitate communication between patient and dietitian by eliminating the need to arrange face-to-face meetings at celiac disease centers, which may be at great distance. Self-monitoring with new technologies for gluten detection in food (e.g., portable gluten sensors) and urine (e.g., gluten immunogenic peptide kits) can facilitate greater individual awareness of gluten exposures, are commercially available to the public, and have been shown to be valid and reliable. Physicians and dietitians are being asked if these technologies should be used, and our preliminary studies have demonstrated acceptability and feasibility, but their impact on clinical outcomes such as mucosal recovery and symptoms has not been established. This U01 proposal is for a multi-center (New York, Massachusetts, Illinois, Tennessee) randomized controlled trial (M-RCT) to assess the effectiveness and document costs of gluten detection technologies as an adjunct to telemedicine on behavioral and clinical outcomes among newly diagnosed patients with celiac disease. Participants will be randomized to receive either 1) standard of care (i.e. a one-time in-person dietitian session plus telemedicine dietitian follow-up; or 2) standard of care + gluten detection technologies. This would be the first large-scale clinical trial to test the effect of self-monitoring using gluten detection technology in the management of celiac disease. The primary outcome will be mucosal recovery 12-months post-randomization. Secondary outcomes include change in gastrointestinal symptoms, diet adherence, quality of life (including anxiety and depression), eating behaviors, intraepithelial lymphocyte counts on histology, and celiac disease serology, all assessed at baseline and again at 12-months post-randomization. If the primary endpoint of this proposed U01 is met, the intervention will improve mucosal recovery, promote a shift in current practice of celiac disease management toward long-term monitoring, and represent a significant step toward reducing the severe physical and psychological consequences of celiac disease.", "keywords": [ "Address", "Adherence", "Adoption", "Adult", "Affect", "Anemia", "Antibodies", "Anxiety", "Autoantibodies", "Awareness", "Behavioral", "COVID-19 pandemic", "Celiac Disease", "Chemistry", "Clinical", "Clinical Management", "Clinical Trials", "Communication", "Complement", "Consumption", "Country", "Detection", "Diagnosis", "Dietitian", "Digestive System Disorders", "Disease Management", "Eating Behavior", "Effectiveness", "Evaluation", "Fatigue", "Food", "Gastroenterology", "Gliadin", "Gluten", "Gluten-free diet", "Grant", "Health", "Health Professional", "Height", "Histology", "Home", "Illinois", "Immune System Diseases", "Immunoglobulin A", "Immunoglobulin G", "Incidence", "Individual", "Infertility", "Infrastructure", "Intervention", "Link", "Lymphocyte Count", "Malignant Neoplasms", "Massachusetts", "Measures", "Mediator", "Mental Depression", "Monitor", "Morbidity - disease rate", "Motivation", "Mucous Membrane", "National Institute of Diabetes and Digestive and Kidney Diseases", "New York", "Newly Diagnosed", "Osteoporosis", "Outcome", "Outcome Study", "Participant", "Pathway interactions", "Patient-Focused Outcomes", "Patients", "Peptide antibodies", "Peptides", "Performance", "Persons", "Physicians", "Pisum sativum", "Population", "Quality of life", "Randomized", "Randomized Controlled Trials", "Recommendation", "Recovery", "Regimen", "Sample Size", "Sampling", "Serology", "Seroprevalences", "Serum", "Social support", "Symptoms", "Technology", "Telemedicine", "Tennessee", "Testing", "Tissue Transglutaminase Antibodies", "Translating", "United States", "Urine", "Videoconferencing", "Villus", "acceptability and feasibility", "antigen test", "clinical development", "comparative cost effectiveness", "cost", "cost comparison", "cost effective", "cost effectiveness", "deamidation", "dietary", "dietary adherence", "effectiveness evaluation", "effectiveness testing", "follow-up", "gastrointestinal symptom", "immunogenic", "improved", "intraepithelial", "meetings", "mortality", "new technology", "novel", "pandemic disease", "portability", "primary endpoint", "primary outcome", "psychologic", "rapid testing", "recruit", "secondary outcome", "sensor", "social", "standard of care", "tool", "validation studies" ], "approved": true } }, { "type": "Grant", "id": "12338", "attributes": { "award_id": "1R15HD112867-01", "title": "Shared Language Erosion Among Chinese Immigrant Families", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 28252, "first_name": "VIRGINIA CHARLOTTE", "last_name": "Salo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-05", "end_date": "2026-08-31", "award_amount": 448800, "principal_investigator": { "id": 28253, "first_name": "Hua", "last_name": "Lin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1192, "ror": "", "name": "OKLAHOMA STATE UNIVERSITY STILLWATER", "address": "", "city": "", "state": "OK", "zip": "", "country": "United States", "approved": true }, "abstract": "Accusations regarding the origins of COVID-19 and ongoing anti-China rhetoric have provoked increases in mental health problems (MHPs) such as anxiety, depression, and suicidal thoughts and behaviors among Chinese American immigrant (CAI) families. Yet, little is known about how CAI families cope with discrimination. Additionally, there is a well-documented increase in the prevalence of MHPs from the 1st to the 2nd and 3rd generations of CAIs. However, little is known about what might be driving this increase. A growing literature shows that upon entering school, immigrant children in general, and Chinese-heritage children in particular, quickly acquire proficiency in English while exhibiting significant declines in their heritage language (HL). Over the same time period, their parents show only modest gains in their English proficiency. The combination of child HL loss and low parental EL acquisition creates a situation in which immigrant children and their parents increasingly do not speak the same language, which we call shared language erosion (SLE). This dynamic creates a growing barrier for Chinese parents and their children to communicate effectively. When communication falters, misunderstandings, frustrations, conflict, and feelings of rejection grow, causing disharmony in the family. Parental competencies that normally would buffer against environmental risks become increasingly ineffective leaving youth vulnerable to the negative impact of discrimination and stress. This may help explain why 2nd and 3rd generation Chinese immigrants are 2~3 times more likely to develop a mental illness and/or attempt suicide relative to their 1st generation counterparts. Because language is the mechanism through which meaning, identity, and relationships evolve and are strengthened, SLE may also impede the development of other protective factors against MHPs such as ethnic identity, engagement with extended kin, and a sense of belonging to an ethnic community. However, these mediated paths from SLE to youth MHPs have not been tested. To assess these linkages the current study aims to: 1) Examine the extent to which the association between SLE and Chinese American immigrant youth's MHPs is mediated by parental efficacy (e.g., monitoring, low conflict, closeness), and whether this path is moderated by youth gender; 2) Examine whether the path from perceived discrimination to MHPs through youth stress is moderated by SLE among CAI youth. We hypothesize that SLE will be positively associated with MHPs, that this association will be mediated by parental efficacy, and will be stronger for females. We also hypothesize that high SLE will exacerbate the negative effects of discrimination on youth MHPs by increasing the indirect effect through youth stress. To accomplish these aims we will sample 167 Chinese immigrant parents (1st generation) whose preferred language is Mandarin and their 1st or 2nd generation youth children (ages 12-17; N=167 parent-child dyads) who have resided in the US for 6 or more years.", "keywords": [ "Academic Research Enhancement Awards", "Address", "Affect", "Age", "Anxiety", "Area", "Asian", "Asian Americans", "Asian population", "Attention", "Automobile Driving", "Buffers", "COVID-19", "Charge", "Child", "Child Rearing", "China", "Chinese", "Chinese American", "Chinese population", "Cities", "Communication", "Communities", "Competence", "Conflict (Psychology)", "Data", "Development", "Discrimination", "Emotional", "English Language", "Environmental Risk Factor", "Ethnic Origin", "Ethnic Population", "Exhibits", "Family", "Family member", "Feeling", "Feeling suicidal", "Female", "Foundations", "Frustration", "Gender", "Generations", "Growth", "Health Personnel", "Home", "Homes for the Aged", "Immigrant", "Immigrant family", "Individual", "Intervention", "Knowledge", "Language", "Language Development", "Linguistics", "Literature", "Mediating", "Mental Depression", "Mental Health", "Mental Health Services", "Mental disorders", "Mentors", "Monitor", "Nature", "Parents", "Pathway interactions", "Population", "Population Growth", "Populations at Risk", "Prevalence", "Prevention strategy", "Process", "Public Health", "Research", "Research Project Grants", "Role", "Sampling", "Schools", "Science", "Stress", "Structure", "Subgroup", "Suicide attempt", "Testing", "Time", "Woman", "Work", "Youth", "behavioral health", "behavioral outcome", "bilingualism", "coping", "ethnic identity", "evidence base", "innovation", "novel", "perceived discrimination", "preference", "prevent", "protective factors", "racial identity", "racial population", "recruit", "skills", "stressor", "suicidal behavior", "suicide rate", "undergraduate student" ], "approved": true } }, { "type": "Grant", "id": "12339", "attributes": { "award_id": "1R35GM150528-01", "title": "Real-time structural and functional studies of SARS-CoV-2 spike proteins", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22244, "first_name": "MICHAEL", "last_name": "SAKALIAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2028-07-31", "award_amount": 389820, "principal_investigator": { "id": 28254, "first_name": "Yi-Chih", "last_name": "Lin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 972, "ror": "", "name": "UNIVERSITY OF TEXAS AT AUSTIN", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract: Spike glycoprotein (S-protein) is one of the viral transmembrane proteins on the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). S- protein plays a crucial role in mediating the initial entry of viral genome into the host cell by binding to the human angiotensin-converting enzyme 2 (ACE2) and then inducing fusion between the virus envelope and cell membrane. Thus, S-protein is a target of choice for diagnostic and therapeutic assays, including neutralizing monoclonal antibodies (nAbs). To date, the conformations of S-protein and its molecular assemblies with ACE2 and/or nAbs have been mainly determined by structural techniques, including crystallographic and electron microscopic methods. These structural studies allow us to understand the molecular basis underlying viral entry and to further develop treatment and preventive therapeutics for COVID-19. However, these resolved structures are rather “static snapshots” compared to the dynamic nature of proteins in physiological conditions. Due to the technical difficulties, our knowledge about the real-time structural dynamics of S-protein and its real-time interactions with host receptors, nAbs, and the other relevant biomolecules, which may have functional significance, is still very limited. In this proposal, my lab will develop a bio-mimicking reconstitution system and apply a cutting-edge structural imaging technique, high-speed atomic force microscopy (HS-AFM), for real-time observations of S- protein’s structural dynamics in close-to-native environments and under various conditions. We will also develop novel methods to quantitatively characterize the architecture of molecular assemblies comprising S-protein, ACE2 receptor, nAbs, host proteases and enzymes, and biological membranes, which can mediate the membrane fusion and viral entry processes. Specifically, we will identify the “real-time” structural dynamics of S- protein in different states and visualize how the state transitions happen, for example, during ACE2 binding, nAbs attachment, and the structural cleavages in S-protein subunits. My lab will further develop correlated fluorescence microscopy and HS-AFM to study these dynamic events associated with S-protein on the mammalian cell surface. The biophysical and biochemical information acquired in our proposed experiments will provide a comprehensive molecular understanding of the conformational states of S-protein, intermolecular interactions between S-protein and binding molecules (ACE2 and nAbs), the conformational changes in S- protein for initiating membrane fusion processes for viral entry, and how the mammalian cell surface impacts the S-protein. The developed methods here can further apply to the other receptor-mediated membrane fusion systems for cell entry.", "keywords": [ "2019-nCoV", "ACE2", "Architecture", "Atomic Force Microscopy", "Binding", "Biochemical", "Biological", "Biological Assay", "Biophysics", "COVID-19", "COVID-19 therapeutics", "Cell membrane", "Cell surface", "Cells", "Crystallography", "Diagnostic", "Electrons", "Environment", "Enzymes", "Event", "Fluorescence Microscopy", "Glycoproteins", "Human", "Imaging Techniques", "Integral Membrane Protein", "Knowledge", "Mammalian Cell", "Mediating", "Membrane", "Membrane Fusion", "Methods", "Microscopic", "Molecular", "Molecular Conformation", "Nature", "Peptide Hydrolases", "Physiological", "Play", "Preventive", "Process", "Proteins", "Role", "SARS-CoV-2 spike protein", "Speed", "Structure", "System", "Techniques", "Therapeutic", "Time", "Viral", "Viral Genome", "Virus", "Visualization", "experimental study", "intermolecular interaction", "molecular assembly/self assembly", "neutralizing monoclonal antibodies", "novel", "receptor", "reconstitution", "structural imaging", "virus envelope" ], "approved": true } }, { "type": "Grant", "id": "12340", "attributes": { "award_id": "1R21HD115355-01", "title": "Identifying adolescent social media response in real-time: Risk and protective factors for Asian American mental health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8605, "first_name": "JAMES", "last_name": "GRIFFIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-19", "end_date": "2025-08-31", "award_amount": 542860, "principal_investigator": { "id": 23755, "first_name": "CINDY H", "last_name": "LIU", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 891, "ror": "https://ror.org/04b6nzv94", "name": "Brigham and Women's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23756, "first_name": "Tiffany", "last_name": "Yip", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 891, "ror": "https://ror.org/04b6nzv94", "name": "Brigham and Women's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "As of 2022, nearly all (95%) adolescents report using at least one social media (SM) platform daily. Adolescents are prone to engage in social comparison with SM users, which may negatively affect their self-concept (SC). Despite the outsized role of SM on adolescent outcomes, little is known about how SM use impacts SC and ultimately mental health. Furthermore, racial minority adolescents may face additional risks to SC when experiencing indirect or vicarious discrimination experiences, including viewing racial stereotypes on SM. Determining Asian American (AA) adolescent responses to race- based SM content can provide key information on the effects of SM on the psychological adjustment of racial minority youth. AA youth experience the most online bullying compared to other racial/ethnic groups and also reported the largest increase in online victimization and exposure to stereotypic SM content since the start of the COVID-19 pandemic. This R21 proposal involving 135 AA adolescents fulfills a gap in the science of how immediate responses to SM content may affect adolescent SC and subsequent mental health. Naturally occurring, popular or “viral ” posts will be presented as experimental stimuli to reflect either stereotypic or counter-stereotypic portrayals of AAs. SC will be assessed immediately through a series of questions to understand how adolescents view themselves, how they compare themselves to others in the post, and whether they or others might perceive their racial group positively or negatively. The long-term objective is to reveal modifiable targets through the direct assessments of psychological processes, specifically how adolescents feel and interpret the messages from social media posts. With implications for cognitive behavioral therapy and mindfulness- based practices for adolescents, our findings have potential for providing evidence-based anticipatory guidance for parents, clinicians, and communities. Our study has the following aims: Aim 1. To test associations between stereotype and counter stereotype race-related SM content and self-concept (SC) using experimental stimuli, and (b) To investigate how race centrality (whether being Asian American is central to one's identity) moderates the links. Aim 2. To examine the mediation pathways of race-related SM content exposure on mental health and psychological outcomes via SC. Exploratory Aim. To determine how adolescents identify messages in social media content, including the extent they identify racial messaging. The major strengths of this work include the generalizability of findings across SM platforms and enhanced ecological validity through the use of real, viral SM posts, with its selection conducted in collaboration with our youth advisory board of AA teens and other AA consultants. Our approach to assess immediate affective and cognitive response to SM has potential to yield groundbreaking insights on how adolescents learn identity-relevant information online.", "keywords": [ "Adolescent", "Affect", "Affective", "Age", "Algorithms", "American", "Asian", "Asian Americans", "COVID-19 pandemic", "Cellular Phone", "Cognitive", "Cognitive Therapy", "Collaborations", "Communities", "Data", "Development", "Discrimination", "Ethnic Origin", "Ethnic Population", "Exposure to", "Family", "Feeling", "Funding", "Health", "Individual", "Infrastructure", "Intervention", "Learning", "Link", "Mediation", "Mental Health", "National Institute of Mental Health", "Nature", "Outcome", "Parents", "Participant", "Pathway interactions", "Persons", "Process", "Psychological adjustment", "Public Health", "Published Comment", "Race", "Reporting", "Research Personnel", "Risk", "Risk Factors", "Role", "Schools", "Science", "Self Concept", "Series", "Social Network", "Socialization", "Source", "Stereotyping", "Stimulus", "Teenagers", "Testing", "Thinking", "Time", "Victimization", "Violence", "Viral", "Work", "Youth", "anti-Asian", "bullying", "critical period", "distress tolerance", "early adolescence", "ethnic identity", "evidence base", "experience", "innovation", "insight", "marginalization", "mindfulness", "minority children", "negative affect", "novel", "peer", "perceived discrimination", "pressure", "protective factors", "psychologic", "psychological outcomes", "racial minority", "racial population", "racism", "response", "social", "social media", "uptake" ], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1419, "count": 14184 } } }