Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=-program_officials
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-program_officials", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=-program_officials", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=-program_officials", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=-program_officials" }, "data": [ { "type": "Grant", "id": "8865", "attributes": { "award_id": "1U54CA267789-01", "title": "SDSU FUERTE: Administrative Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-21", "end_date": "2026-08-31", "award_amount": 224710, "principal_investigator": { "id": 24683, "first_name": "Mark Brian", "last_name": "Reed", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 775, "ror": "https://ror.org/0264fdx42", "name": "San Diego State University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 775, "ror": "https://ror.org/0264fdx42", "name": "San Diego State University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "ADMINISTRATIVE CORE – Project Summary Human health is negatively impacted by the lack of gender, racial, and ethnic diversity in biomedical and health sciences research in the United States. This lack of diversity adversely impacts discovery, innovation, and the advancement of scientific knowledge. Moreover, this point is particularly salient, as the COVID-19 pandemic has differentially affected the mortality and morbidity of communities of color in the US. Lower numbers of historically underrepresented minorities in biomedical and health sciences research fields are evident in both the undergraduate and graduate levels of training as compared to the general US population, but are even more amplified among the faculty ranks in American research universities and medical schools. San Diego State University (SDSU) is proposing a new and innovative program, SDSU FUERTE (Faculty Unified towards Excellence in Research and Transformational Engagement). This program aims to ameliorate this disparity by recruiting a diverse cohort of health sciences researchers focused on Latinx health disparities and implementing a comprehensive Faculty Development Plan, comprised of a multi-perspective mentoring team approach as well as a new centralized Core Curriculum that applies evidence-based strategies to accelerate the research and professional academic advancement success of its faculty. One of three cores supporting SDSU FUERTE, the Administrative Core is first and foremost responsible for overseeing a new institutional process for successfully recruiting this diverse, nine-person, interdisciplinary faculty cohort who will begin at SDSU in the Fall of 2022. The Administrative Core will be critical to these efforts and will be led by a highly experienced leadership team charged to promote buy-in and accountability for the SDSU FUERTE initiative which is mandating a new level of inclusive excellence approaches and strategies at all levels of the SDSU community. The management and coordination of the SDSU FUERTE program will occur through a well- defined administrative structure which will receive essential input from an External Advisory Board and an Internal Advisory Board comprised of nationally and institutionally recognized leaders. The Administrative Core will also facilitate and support the essential synergies between the Faculty Development Core and the Evaluation Core by serving as the central hub for coordination and information exchange.", "keywords": [ "Accountability", "Affect", "American", "Area", "Biomedical Research", "COVID-19 pandemic", "COVID-19 vaccine", "Charge", "Climate", "Color", "Communication", "Communities", "Development", "Development Plans", "Discrimination", "Doctor of Philosophy", "Economics", "Educational Curriculum", "Educational Status", "Ensure", "Environmental Health", "Evaluation", "Faculty", "Faculty Recruitment", "Funding", "Goals", "Health", "Health Personnel", "Health Sciences", "Hispanic-serving Institution", "Human", "Institution", "Knowledge", "Latinx", "Leadership", "Medical", "Mentors", "Morbidity - disease rate", "Obesity", "Operations Research", "Outcomes Research", "Persons", "Physical activity", "Population", "Positioning Attribute", "Principal Investigator", "Process", "Productivity", "Public Health", "Recording of previous events", "Research", "Research Personnel", "STEM field", "Science", "Social Work", "Structure", "Students", "Teacher Professional Development", "Underrepresented Minority", "United States", "United States National Institutes of Health", "Universities", "addiction", "cohort", "community engagement", "diversity and equity", "ethnic diversity", "evidence base", "experience", "falls", "gender diversity", "health disparity", "health science research", "higher education", "improved outcome", "innovation", "interest", "maltreatment", "medical schools", "model development", "mortality", "nutrition", "organizational climate", "professor", "programs", "racial diversity", "recruit", "skills", "success", "synergism", "tenure track", "undergraduate student" ], "approved": true } }, { "type": "Grant", "id": "8884", "attributes": { "award_id": "1U01IP001154-01", "title": "IP21-002, US Enhanced Surveillance Network to Assess Burden, Natural History, and Effectiveness of Vaccines to Prevent Enteric and Respiratory Viruses in Children", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1441647, "principal_investigator": { "id": 11321, "first_name": "Jennifer E", "last_name": "Schuster", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1199, "ror": "", "name": "CHILDREN'S MERCY HOSP (KANSAS CITY, MO)", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24699, "first_name": "Rangaraj", "last_name": "Selvarangan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1199, "ror": "", "name": "CHILDREN'S MERCY HOSP (KANSAS CITY, MO)", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "Component A: Project Summary The Kansas City-New Vaccine Surveillance Network (KC-NVSN) program has been performing population-based, laboratory-confirmed, active surveillance of acute gastroenteritis (AGE) illness and acute respiratory illness (ARI) in children seeking care at Children’s Mercy (CM), in Kansas City (KC), MO since 2009 and 2015, respectively. In the current proposal, the KC-NVSN program seeks to continue the existing pediatric AGE and expand the pediatric ARI surveillance to the six county KC metropolitan area for children seen in CM’s inpatient and emergency department (ED) settings. Age- and time-matched healthy control children seeking well-child care in the outpatient setting will also be enrolled. We will enroll eligible children (as defined in the proposal) visiting or admitted to our hospital system using permission and assent forms approved by CM’s institutional review board (IRB). After enrollment, we will interview parents, collect EMR chart data, and retrieve hard copies of receipt of influenza and rotavirus (RV) vaccine, and any future vaccines (SARS-CoV-2, RSV, NoV). Stool specimens will be tested for RV, norovirus (NoV), and other GI pathogens, and respiratory specimens for 23 respiratory pathogens, e.g., influenza (types and specific subtypes) and other non-influenza viruses (RSV, EV-D68, and SARS-CoV-2, etc). We will use prospective surveillance for acute flaccid myelitis (AFM) characterizing the clinical disease spectrum and burden rates. KC-NVSN data will provide population-based estimates to address the following specific aims: 1. To assess the burden of AGE and ARI pathogens among enrolled children. 2. To assess vaccine effectiveness (VE) against medically attended illness due to RV, influenza, and upcoming vaccines via laboratory-confirmed testing among enrolled children. 3. To assess AFM clinical spectra and burden and associations with ARI and AGE illnesses. The KC-NVSN program data will be combined with other geographically diverse sites’ data to estimate the national incidence, burden, and etiology of community-acquired AGE and ARI and VE for rotavirus and seasonal influenza vaccinations. This network will also address several important scientific questions related to the natural history of pediatric infectious diseases, transmission dynamics, impact of vaccine on targeted and vulnerable populations, and factors influencing VE. The surveillance data generated from this network will provide timely and highly useful data to inform public health measures and pediatric vaccine-related policies aimed at controlling AGE and ARI in US children.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8898", "attributes": { "award_id": "1U01IP001155-01", "title": "US Enhanced Surveillance Network to Assess Burden, Natural History, and Effectiveness of Vaccines to Prevent Enteric and Respiratory Viruses in Children", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1441646, "principal_investigator": { "id": 7500, "first_name": "MARY A", "last_name": "STAAT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "ABSTRACT- MANDATORY CORE The purpose for Mandatory Core Component A is to support an Enhanced Surveillance Network of US pediatric institutions to develop and implement standard research protocols to conduct prospective active population-based surveillance in defined inpatient and emergency department (ED) settings for a) acute gastroenteritis (AGE) due to norovirus, rotavirus and other enteric pathogens, b) acute respiratory infection (ARI) due to respiratory viruses including influenza, RSV, parainfluenza viruses, human metapneumovirus, rhinoviruses, enteroviruses (including EV-D68), adenoviruses, coronaviruses (including SARS-CoV-2) and other respiratory viruses, c) and healthy controls (HC) and d) Acute Flaccid Myelitis (AFM) syndrome among pediatric patients seeking healthcare at these pediatric medical institutions. The results from this program will be used to inform vaccine recommendations and assess the public health impact of the US rotavirus, influenza and SARS-CoV-2 vaccination programs and provide epidemiologic data for other infectious diseases with therapeutics and vaccines in development. There are two objectives for Mandatory Core Component A:: For Objective 1 we will conduct population-based active surveillance for respiratory and enteric viral pathogens in pediatric inpatient and ED settings and enroll asymptomatic healthy controls in Hamilton Co. children <18 years of age. Through our already established ARI, AGE and HC Surveillance Platforms we will 1) perform active surveillance to determine the etiology and burden of inpatient and ED acute viral enteric and respiratory diseases in our defined population, 2) characterize the clinical and epidemiologic factors of infections including asymptomatic children and 3) evaluate VE and impact of vaccines and other interventions available or projected to become available during the study agreement period for rotavirus and influenza vaccines using a test- negative design and for RSV and SARS-CoV-2, when available and recommended for children and adolescents. For Objective 2 we will conduct surveillance activities for acute flaccid myelitis (AFM in hospitalized children <18 years of age). Through our already established AFM Surveillance Platform, we will 1) define baseline rates of AFM in our pediatric institution through active case finding in collaboration with our Neurology and Neuroradiology Co-Investigators using the CDC's case definition for patients meeting the clinical criterion for AFM and a spinal MRI showing at least some gray matter involvement by conducting active surveillance and establishing incident rates for AFM among hospitalized children within our catchment area, 2) compare rates of AFM to rates of circulating respiratory and enteric pathogens at our site from our population- based active surveillance program and 3) characterize the clinical spectrum of pediatric AFM and compare with the clinical spectrum seen with other similar neurologic conditions.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8915", "attributes": { "award_id": "1U01CK000630-01", "title": "CK21-003, Oregon Child Absenteeism due to Respiratory Disease Study - 3", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2024-08-31", "award_amount": 967373, "principal_investigator": { "id": 24738, "first_name": "JONATHAN L", "last_name": "TEMTE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 799, "ror": "", "name": "UNIVERSITY OF WISCONSIN-MADISON", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 799, "ror": "", "name": "UNIVERSITY OF WISCONSIN-MADISON", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "SUMMARY/ABSTRACT Background: Influenza (Flu) is common in children and a leading cause of school absenteeism. SARS-CoV-2 (SARS) has emerged as a significant pathogen, but the role of children in post-peak and post-pandemic transmission needs to be defined. Both viruses cause substantial morbidity, mortality and economic costs. As Flu is efficiently spread within school settings, rates of absenteeism have been proposed as an early warning system. Accordingly, we created and tested a simple modification of an existing electronic school information system (ESIS) to automatically report cause-specific absenteeism. We found a significant association between cause-specific K-12 school absenteeism and prevalence of medically-attended Flu in our six-year study, allowing for Flu monitoring and early warning for acceleration in community activity. We have also documented substantial within-household Flu transmission. Similar studies— using our established and effective methods—are needed for the newly emerged coronavirus, SARS. Program Goal: The goals of ORCHARDS-3 are to expand the absenteeism system to evaluate the effectiveness for SARS monitoring and to describe the level of within-household transmission of Flu and SARS from index cases who are school-aged children. Methods: We will use parental reporting of symptoms into a telephonic absence reporting system and an algorithm within the ESIS for daily absenteeism assessment. We will actively recruit ≥300 children absent due to Flu-like illness (ILI) or COVID-like illness (CLI) from the Oregon School District, Dane County, WI, in each of three years. Home visits will be used to collect detailed demographic, household, epidemiologic and symptom data, and nasal and NP/OP specimens for testing. Nasal specimens will be tested for Flu/SARS using SOFIA-2 FIA rapid testing. NP/OP specimens will be transported to the Wisconsin State Laboratory of Hygiene for Flu/SARS rRT-PCR testing and for the presence of other respiratory viruses using a Luminex Multiplex PCR platform. We will recruit ≥240 households/yr with ill children for transmission assessment. All household members will self-collect nasal specimens on day 0, 7 and 14 for Flu/SARS rRT-PCR and provide detailed illness data. Temporal patterns of absenteeism due to ILI and CLI will be compared to virological surveillance within the surrounding community. Rates of within-home transmission of Flu and SARS will be calculated. Significance: Transmission and amplification within schools, followed by transmission from children to other household members likely expands outbreaks. Cause-specific absenteeism monitoring of Flu and SARS may provide early detection in a community allowing for use of countermeasures.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8928", "attributes": { "award_id": "1U01GH002366-01", "title": "GH21-001, Conducting Public Health Research in Thailand: Technical collaboration with the Ministry of Public Health (MOPH) in the Kingdom of Thailand", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1568022, "principal_investigator": { "id": 24754, "first_name": "Kiattibhoom", "last_name": "Vongrachit", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1778, "ror": "", "name": "THAILAND MINISTRY OF PUBLIC HEALTH", "address": "", "city": "", "state": "", "zip": "", "country": "THAILAND", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1778, "ror": "", "name": "THAILAND MINISTRY OF PUBLIC HEALTH", "address": "", "city": "", "state": "", "zip": "", "country": "THAILAND", "approved": true }, "abstract": "The collaboration between CDC and Thailand MoPH have led to breakthroughs in research, improved programmatic practices and strengthened laboratory system. This is an umbrella Cooperative Agreement that will facilitate collaboration between Programs/Divisions within CDC Thailand and Thailand MoPH for the conduct of Public Health research on diseases of importance to both the United States and Thailand. The Permanent Secretary of Thailand MoPH is the Principle Investigator (PI) for this Research Cooperative Agreement and assigned Director of Strategy and Planning Division (SPD) to be business official will oversee project implementation and management through the project period respectively. The overall objectives of the MoPH CoAg project is to conduct epidemiologic, clinical field and laboratory research on important human infectious diseases, with emphasis on HV/AIDs, malaria, emerging and re- emerging infectious diseases, zoonotic diseases, , neglected tropical diseases, tuberculosis , influenza, coronaviruses and other diseases with pandemic potential, research on mobile and vulnerable populations including environmental health, chronic diseases, birth defects and developmental disabilities, maternal and child health, public health preparedness, biosafety and injury control and prevention. Results of this research project will be incorporated into operational system, surveillance, diseases control and prevention program in Thailand, including capacity building and sharing data to other agencies. In this application, the MoPH has proposed total of 12 projects, which comprised of 6 new projects and 7 continuation projects under programs as following:- 1. Coordinating Unit- CU1-MoPH The Ministry of Public Health Coordinating Unit(Continuation) 2. The Division of Global Health Protection (DGHP)- 2 projects: DGHP-AFINGS-BIDI (New) and DGHP- Sepsis-NGS (New) 3. Division of HIV/AIDS Prevention (DHAP)- 5 Projects: DHAP-COSERO (New), DHAP-HPTN083 (Continuation), DHAP-Main (Continuation), DHAP-TGW (Continuation), DHAP-ZOLI (Continuation) 4. Division of Global Migration and Quarantine (DGMQ)- 1 project: DGMQ-MNPC (New) 5. Non-Communicable Diseases (NCD)- 1 Project: FETP-NCD (New) 6. Influenza Program (FLU)- 2 projects: FLU-COVID-EPBI (Continuation), Flu-Serology (Continuation) Please see details of each project in attached file name-", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8936", "attributes": { "award_id": "1U01IP001158-01", "title": "IP21-002, Enhanced Surveillance Network for Enteric and Respiratory Viruses in Children: Assessing Disease Burden, Natural History, and Vaccine Effectiveness", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1441647, "principal_investigator": { "id": 24763, "first_name": "Geoffrey Alan", "last_name": "Weinberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 464, "ror": "https://ror.org/022kthw22", "name": "University of Rochester", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 464, "ror": "https://ror.org/022kthw22", "name": "University of Rochester", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "(COMPONENTS A, B and C): Viral acute respiratory infections (ARI) and acute gastroenteritis (AGE) remain major causes of morbidity in children, making vaccine development and implementation a high public health priority. The overall goal of the CDC New Vaccine Surveillance Network (NVSN) is to establish a network of US institutions that develop and implement standard research protocols to answer important questions about the burden of disease and natural history of vaccine preventable diseases, specifically, those causing ARI and AGE. A second goal of population-based NVSN surveillance is to provide accurate estimates of vaccine effectiveness (VE) in preventing pediatric hospitalization or medical care visits. A third goal is the ability to rapidly pivot to study novel agents such as enterovirus-D68 (EV-D68) or SARS-CoV-2, and syndromes such as acute flaccid myelitis (AFM) and multisystem inflammatory syndrome in children (MIS-C). The proposed work (comprising Mandatory Core A, and Optional Components B and C) will enhance the NVSN site in Rochester, NY—one of 2 original members of the now 7-site network. For 20 years we have published important studies on the burden of disease and natural history of AGE due to rotavirus and norovirus, and ARI due to influenza, (RSV), and other viruses. These data helped inform AAP and ACIP on pediatric influenza and rotavirus vaccination, and palivizumab use for RSV prevention. Our specific aims are: Mandatory Core Component A: Perform prospective, population-based active surveillance for ARIs and AGEs in inpatient and ED settings as well as asymptomatic controls, for children 0-18 years. We will use molecular diagnostics for rotavirus, norovirus, influenza, RSV, PIV, EV-D68, SARS-CoV-2, and other viruses. We will assess VE for influenza, rotavirus, and future SARS-CoV-2 vaccines in preventing pediatric hospitalizations and ED visits. We will delineate the disease burden of ARI and AGE using our unique capture of virtually all pediatric hospitalizations and ED visits in our region. We will assess the impact of future vaccines and other immunoprophylaxis strategies. We will perform active surveillance and epidemiologic studies of acute flaccid myelitis (AFM) syndrome in children. Finally, we will perform and lead epidemiological, implementation and laboratory studies based on population-based NVSN surveillance. Optional Component B: Implement active prospective population-based ARI/AGE surveillance studies in children seeking medical care in outpatient practices, as the burden of ARI and AGE are likely high. Optional Component C: Investigate the incidence, spectrum of disease, and risk factors associated with SARS-CoV-2 MIS-C. Our proposed research will provide high impact information to develop sound policies for the prevention of pediatric vaccine-preventable diseases, and to improve the health of US children.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8942", "attributes": { "award_id": "1U01IP001152-01", "title": "IP21-002, New Vaccine Surveillance Network", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1402123, "principal_investigator": { "id": 24772, "first_name": "Marian G", "last_name": "Michaels", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24773, "first_name": "John V.", "last_name": "Williams", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 848, "ror": "", "name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "(For Components A, B, and C). Acute gastroenteritis (AGE) and acute respiratory illness (ARI) are leading causes of childhood disease, accounting for a large proportion of hospitalizations, Emergency Department (ED) visits, and outpatient visits annually in the US. These illnesses are caused by diverse pathogens, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza viruses, rhinovirus, enterovirus (EV), coronavirus including SARS-CoV-2, adenovirus, rotavirus, norovirus, astrovirus, and sapovirus. Moreover, some of these viruses are associated with other emerging childhood syndromes, including acute flaccid myelitis (AFM) associated with EV, and multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2. Thus, viral AGE and ARI are of major public health importance, and result in serious long-term consequences for some children. There are few or no effective antivirals for these viruses and vaccination is the most promising intervention. Our goals are to conduct active, prospective population-based surveillance for AGE and ARI; to define the burden of vaccine-preventable diseases; describe the clinical features, natural history, and population dynamics; and establish vaccine effectiveness (VE) of licensed and impending vaccines and monitor VE over time. The New Vaccine Surveillance Network (NVSN) will facilitate these goals. We propose four Specific Aims: Aim 1: to conduct prospective active surveillance for AGE due to norovirus, rotavirus, and other enteric viruses among children seeking healthcare in ED, inpatient, and outpatient settings. (Component A, Mandatory Component 1; Optional Component B) Aim 2: to conduct prospective active surveillance for ARI due to respiratory viruses in these settings. (Component A, Mandatory Component 1; Optional Component B) Aim 3: to conduct prospective active surveillance for AFM syndrome in these settings. (Component A, Mandatory Component 2) Aim 4: to conduct prospective active surveillance for MIS-C. (Optional Component C) The Pittsburgh site has extensive experience with pediatric clinical research, including as a top enrolling NVSN site in the current NVSN cycle. UPMC Children’s Hospital of Pittsburgh (CHP) has a catchment area of >5.5 million people and admits >95% of hospitalized children in the surrounding county of >1.2 million. Thus, the environment is excellent for population-based research. The experienced investigative team includes experts from pediatric infectious diseases, critical care, rheumatology, and cardiology. The data and samples collected in this project will facilitate the capacity to calculate VE for multiple licensed and pending vaccines. The results of this project will inform best practices for diagnosis and treatment, guide vaccine recommendations, and determine public health interventions to prevent viral illness-related medical visits among children.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8954", "attributes": { "award_id": "1IK6HX003395-01", "title": "HSR&D Senior Research Career Scientist Award", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 24789, "first_name": "Denise M.", "last_name": "Hynes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1518, "ror": "https://ror.org/02v3txv81", "name": "Portland VA Medical Center", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1518, "ror": "https://ror.org/02v3txv81", "name": "Portland VA Medical Center", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "As a VA Core Investigator at the HSR&D Center to Improve Veteran Involvement in Care and the Evidence Synthesis Program Coordinating Center based at the Portland VA Healthcare System, my current research activities include Scholarly Research, Training emerging scientists, and leading and participating in Service to VA research and clinical programs. My current work is innovative and highly relevant for one of the most dynamic and transformative periods for healthcare systems broadly, and for VA healthcare especially. The overarching goal of my Scholarly Research activities is to understand and identify ways to improve chronic disease management, including access, quality, and economic outcomes. I direct research on the potential for care coordination models to improve chronic disease management for high risk/high need Veterans and to offset any adverse effects of multi-system health care use across the VA and non-VA health systems. My past research focused on Veterans with chronic kidney disease and cancer led to my current focus on high risk/high need Veterans, including ongoing research on Veterans recovering from COVID-19 illness. Our HSR&D grant pending “Care Coordination and Outcomes for High Risk Patients: Building the Evidence for Implementation”, seeks to identify the current care coordination processes and data resources necessary to conduct a VA implementation study aimed at improving patient and provider experience and health outcomes across VA and non-VA settings. The project also includes partnership with the VA Offices of Community Care, Nursing, and Social Work and other VA offices. Proactive dissemination of my research findings is done through briefings at stakeholder meetings and professional society meetings. I will continue to produce peer reviewed publications of my own research and seek a new opportunity to edit a journal supplement on care coordination as more evidence on implementation science grows and yields results. My research Training activities aim to develop the next generation of VA health services researchers with focus on skill development in methods, measurement, and applying health data resources. I am currently mentoring four VA early career clinician scientists and one PhD postdoctoral fellow. As a graduate program director in Health Management and Policy in my university role, I am and will continue to mentor MPH and PhD candidates and make them aware of the opportunities the VA offers in HSR&D research careers. Further, with faculty roles in Oregon State University (OSU) College of Public Health and Human Sciences, the OSU Center for Genome Research and Biocomputing, and Oregon Health and Science University, together with a new HSR&D Senior Research Career Scientist award, I will be uniquely positioned to develop a new training program that draws on these multi-institutional relationships. My vision is to develop a new training program in Data Science for Better Health, including data science to support care coordination process and outcome measurement and analytics. The goals of my research Service activities are to share my research expertise to inform clinical policy and practice and to contribute to the VA research programs. I will continue involvement in the national VA efforts to inform implementation of care coordination practice alongside our research. My contributions to research programs will include continued support of our Veteran engagement efforts, and participation in peer review activities and on advisory boards for critical VA research programs. An award as a Senior Research Career Scientist would provide me with the opportunity to continue and enrich these important research activities in conducting scholarly and impactful research, training the next generation of scientists, and enhancing the visibility of VA research through leadership and service, and ultimately benefiting the Veterans served by VA health systems.", "keywords": [ "Address", "Adverse effects", "Anemia", "Appointment", "Award", "Awareness", "COVID-19", "Caring", "Case Management", "Chronic", "Chronic Disease", "Chronic Kidney Failure", "Clinical", "Clinical Practice Guideline", "Communities", "Cost Savings", "Data", "Data Analyses", "Data Science", "Depression screen", "Dialysis procedure", "Discipline of Nursing", "Disease Management", "Doctor of Philosophy", "Dose", "Erythropoietin", "Evaluation", "Faculty", "Family", "Fellowship", "Funding", "General Population", "Genome", "Geography", "Goals", "Grant", "Health", "Health Policy", "Health Sciences", "Health Services", "Health Services Accessibility", "Health system", "Healthcare", "Healthcare Systems", "Hearing", "Hemodialysis", "Human", "Information Resources", "Information Systems", "Intervention", "Joints", "Journals", "Kidney", "Kidney Diseases", "Knowledge", "Lead", "Leadership", "Link", "Measurement", "Medical", "Medicare", "Medicare/Medicaid", "Medication Management", "Medicine", "Mentors", "Methods", "Modeling", "Nurses", "Oregon", "Outcome", "Patients", "Peer Review", "Policies", "Positioning Attribute", "Postdoctoral Fellow", "Primary Health Care", "Private Sector", "Process", "Professional Organizations", "Provider", "Public Health", "Public Health Informatics", "Publications", "Quality of Care", "Quality of life", "Renal carcinoma", "Research", "Research Activity", "Research Personnel", "Research Training", "Resources", "Role", "Saran", "Savings", "Scholarship", "School Nursing", "Science", "Scientist", "Seminal", "Services", "Social Work", "Speed", "System", "Technical Expertise", "Training", "Training Activity", "Training Programs", "Translations", "Universities", "Veterans", "Vision", "Work", "base", "biocomputing", "care coordination", "care costs", "care outcomes", "career", "clinical practice", "college", "community based care", "cost", "data resource", "economic outcome", "experience", "health data", "health management", "high risk", "implementation efforts", "implementation research", "implementation science", "implementation study", "improved", "innovation", "meetings", "military veteran", "next generation", "payment", "post-doctoral training", "professor", "programs", "routine practice", "service engagement", "skill acquisition", "socioeconomics", "subcutaneous", "symposium", "working group" ], "approved": true } }, { "type": "Grant", "id": "8955", "attributes": { "award_id": "1IS1BX005567-01", "title": "ShEEP request for Andor Dragonfly High Speed Confocal Platform", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2022-09-30", "award_amount": null, "principal_investigator": { "id": 24790, "first_name": "Nicole Faron", "last_name": "Liachko", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1512, "ror": "", "name": "VA PUGET SOUND HEALTHCARE SYSTEM", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1512, "ror": "", "name": "VA PUGET SOUND HEALTHCARE SYSTEM", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Request for an Andor Dragonfly High Speed Confocal Platform. We are requesting the purchase of an Andor Dragonfly spinning disk confocal microscope (aka Dragonfly) for high- speed and high-resolution imaging of microscopic cellular features. This instrument incorporates high-speed fully scalable state-of-the-art confocal imaging capable of resolving sub-cellular protein targets at the cell membrane using total internal reflectance (TIRF), or deeper in the cell with SRRF-Stream and dSTORM super-resolution techniques. The Dragonfly uses Imaris for real-time graphics processing unit (GPU)-based image processing providing seamless integration with downstream image processing workflows and data analysis, platform interoperability, improved data integrity, audit compliance, and user productivity. The Dragonfly uses a proprietary multi-point confocal for high-speed and high- sensitivity imaging that is at least 10 times faster than conventional confocal technology. The unique illumination method enables even signal intensity across the field of view. The Dragonfly is the optimal solution to meet a broad array of rigorous live cell imaging needs that encompass analysis of behaving brain cells in ex vivo experiments examining calcium dynamics or neuroimmune cell function, cellular transport, synaptic vesicle trafficking, immune cell mobility and infiltration assays among others. As such, it will advance research into Aging, Dementia, Traumatic brain injury, and other emergent health concerns including COVID-19. The instrument will be placed in VA Puget Sound Health Care System (VA PSHCS) GRECC research space (Building 1 7th floor) and operated by trained staff. Primary users are BLR&D Merit review funded GRECC core staff: Drs. David Cook, Nicole Liachko, Brian Kraemer, Jose Garcia, and Chang-en Yu. Secondary users are MIRECC Investigators Jeffery Iliff, Dianne Lattemann, and James Meabon as well as GRECC core staff Erik Carlson and CDA2 recipient Rebecca Kow. Purchase of the Dragonfly is expected to increase the competitiveness of the overall VA PSHCS research program, significantly increase effectiveness and efficiency of confocal microscope imaging, and further the GRECC and MIRECC research missions by providing instrumentation necessary for robust cell and tissue based investigations into the molecular mechanisms of disease and aging.", "keywords": [ "Acute Disease", "Aging", "American", "Amyotrophic Lateral Sclerosis", "Area", "Basic Science", "Biological Assay", "COVID-19", "Calcium", "Cell Mobility", "Cell membrane", "Cell physiology", "Cells", "Cellular Structures", "Chronic Disease", "Clinical Research", "Color", "Confocal Microscopy", "Data", "Data Analyses", "Dementia", "Disease", "Effectiveness", "Elderly", "Floor", "Funding", "Health", "Healthcare Systems", "Image", "Immune", "In Vitro", "Infiltration", "Informatics", "Infrastructure", "Institution", "Investigation", "Lighting", "Mental disorders", "Metabolic Diseases", "Methods", "Microscope", "Microscopy", "Mission", "Molecular", "Neuroimmune", "Output", "Performance", "Photobleaching", "Phototoxicity", "Process", "Productivity", "Property", "Protein Dynamics", "Proteins", "Research", "Research Personnel", "Research Priority", "Research Support", "Resolution", "Sheep", "Signal Transduction", "Speed", "Stream", "Synaptic Vesicles", "System", "Techniques", "Technology", "Testing", "Time", "Tissues", "Training", "Traumatic Brain Injury", "Veterans", "archive data", "base", "brain cell", "clinical center", "confocal imaging", "cooking", "cost", "data archive", "data integrity", "data sharing", "digital", "education research", "experimental study", "high resolution imaging", "image processing", "imaging capabilities", "improved", "in vivo", "instrument", "instrumentation", "interoperability", "live cell imaging", "microscopic imaging", "molecular imaging", "programs", "protein protein interaction", "rehabilitation research", "repository", "research and development", "research study", "single molecule", "sound", "systems research", "trafficking" ], "approved": true } }, { "type": "Grant", "id": "8956", "attributes": { "award_id": "1I01HX003304-01A1", "title": "Optimizing Veteran Recovery from Sepsis (OVeR-Sepsis)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-10-01", "end_date": "2025-09-30", "award_amount": null, "principal_investigator": { "id": 24791, "first_name": "Hallie Christine", "last_name": "Prescott", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24792, "first_name": "Jeremy Broder", "last_name": "Sussman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1477, "ror": "https://ror.org/05eq41471", "name": "Veterans Health Administration", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "Background. Sepsis—life-threatening organ dysfunction triggered by infection—hospitalizes more than 25,000 Veterans each year, making it the 2nd most common reason for hospitalization in the VA. While most Veterans survive the acute episode, many suffer poor longer term outcomes. Approximately 1 in 3 survivors die in the year following sepsis, 1 in 5 have a potentially preventable rehospitalization, and 1 in 6 experience severe persistent physical or cognitive impairments. The dramatic increase in sepsis from COVID-19 brings new urgency to optimizing sepsis survivorship, but also new opportunity to learn from hospitals implementing recovery-focused practices to address the needs of Veterans surviving viral sepsis from SARS-CoV-2. Significance. Despite the prevalence of long-term morbidity after sepsis, there are no treatment guidelines focused on enhancing recovery from sepsis. OVeR-Sepsis will meet an urgent clinical need in VA, enhancing the recovery of the thousands of Veterans who survive sepsis each year (including viral sepsis from COVID). OVeR-Sepsis will validate best practices for enhancing recovery from sepsis that are responsive to Veteran and caregiver perspectives and identify feasible strategies for implementation. We will make these tools freely available, easy to use, and promote them nationally to encourage their use. Innovation and Impact. OVeR-Sepsis is innovative by studying sepsis survivorship systematically and broadly. We will study survivorship from both COVID and non-COVID sepsis, and consider how innovation in COVID sepsis survivorship practices can inform practice for non-COVID sepsis survivors. Our sequential explanatory mixed methods approach, with video site visits for 4-6 top- and 4-6 bottom- performing sites for sepsis survivorship, will allow us to study of clinical practices and implementation strategies that differentiate top-performing sites. We will then incorporate qualitative findings from our site visits into the evidence synthesis informing a modified Delphi panel to assess best practices for sepsis recovery. Specific Aims. (A1) Identify top- and bottom-performing VA hospitals for 90-day survival and quality of life after sepsis. (A2) Define practices that differentiate top-performing hospitals through electronic health record analysis, surveys, and video site visits. (A3) Prioritize best practices for sepsis recovery based on validity, improvement opportunity, and feasibility. Methodology. We will measure risk-standardized 90-day survival from sepsis across VA hospitals using hierarchical regression models and 2017-2020 CDW data. We will then empanel a cohort of N=600 Veterans from (25 Veterans per hospital, from 12 higher- and 12-lower survival hospitals) to measure quality of life and disability using telephone survey instruments with proxy respondent options. From those, we will select 4-6 top-performing (higher survival, high quality of life) and 4-6 bottom- performing hospitals for 360-degree video site visits. Through quantitative analyses of select practices, survey of current practices, and semi-structured interviews with a diverse set of 12-15 informants (clinicians, administrators, Veterans, caregivers), we will identify “best practices” for sepsis recovery and associated implementation strategies. Using a modified Delphi panel of experts, we will assess the validity, improvement opportunity, and feasibility of these best practices. Next Steps/Implementation. Upon successful completion of this research, we will work with our operational partners—who we have included even in the design stage of this IIR—to implement these best practices.", "keywords": [ "2019-nCoV", "Acute", "Address", "Administrator", "Adopted", "Awareness", "COVID-19", "COVID-19 pandemic", "Caregivers", "Caring", "Censuses", "Characteristics", "Chronic", "Clinical", "Clinics and Hospitals", "Cognitive", "Creativeness", "Critical Care", "Data", "Diffusion", "Disasters", "Electronic Health Record", "Epidemiology", "Family", "Functional disorder", "Future", "Goals", "Guidelines", "Health system", "Hospitalization", "Hospitals", "Impaired cognition", "Incidence", "Infection", "Intervention", "Interview", "Learning", "Life", "Measures", "Medical", "Methodology", "Methods", "Modeling", "Morbidity - disease rate", "Nursing Research", "Organ", "Outcome", "Patients", "Pharmaceutical Preparations", "Prevalence", "Primary Health Care", "Professional Organizations", "Proxy", "Public Health", "Qualitative Research", "Quality of life", "Recommendation", "Recovery", "Research", "Resolution", "Respondent", "Review Literature", "Risk", "Sepsis", "Sepsis Syndrome", "Series", "Site", "Site Visit", "Standardization", "Structure", "Surveys", "Survivors", "Telephone", "Veterans", "Viremia", "Work", "World Health Organization", "World Health Organization Disability Assessment Schedule", "base", "clinical epidemiology", "clinical implementation", "clinical practice", "cohort", "coronavirus disease", "design", "disability", "epidemiology study", "experience", "hospital readmission", "implementation strategy", "improved", "informant", "innovation", "multidisciplinary", "pandemic disease", "primary caregiver", "survivorship", "tool", "treatment guidelines", "treatment research", "virtual" ], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1424, "count": 14236 } } }