Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=-other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=-other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=-other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=-other_investigators" }, "data": [ { "type": "Grant", "id": "10499", "attributes": { "award_id": "3R01MH127961-01A1S1", "title": "Utilizing All of Us data to examine the impact of COVID-19 on mental health among people living with HIV", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 24064, "first_name": "Lori", "last_name": "Scott-Sheldon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-16", "end_date": "2023-11-30", "award_amount": 107340, "principal_investigator": { "id": 4919, "first_name": "Xiaoming", "last_name": "Li", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 930, "ror": "", "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 930, "ror": "", "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "In response to the NOSI (NOT-PM-22-002), we propose to expand the resilience conceptual framework in our parent grant (1R01MH127961-01A1, 12/2021-11/2026) to a different context (COVID-19) and a new population (people living with HIV [PLWH] in the United States). Further, we propose to explore if a resilience approach can be used to mitigate the negative impacts of COVID-19 on the mental health among PLWH. We will leverage multiple datasets from the All of Us program, including electronic health records (EHR), a series of COVID-19 Participant Experience (COPE) surveys, and other self-reported survey data. Integrating these data from about 12 thousand PLWH who participated in COPE, we will: 1) examine the trends and patterns of mental health outcomes (i.e., psychiatric disorder diagnoses via ICD-10 and mental health assessments via survey) among PLWH before and after the COVID-19 outbreak; and 2) identify protective factors at multiple socioecological levels including the individual level (e.g., resilience), interpersonal level (e.g., social support), and health institutional level (e.g., health service accessibility) that may mitigate the negative impacts of the COVID-19 pandemic on mental health outcomes among PLWH, especially the subgroups with socially disadvantaged status (low income and low education) and stigmatized identities (racial/ethnic minorities, sexual and gender minorities). Based on rich data from a large cohort of PLWH, the findings will advance our understanding of their mental health needs during the pandemic and mental health disparities of PLWH in the US and inform tailored health interventions to improve mental health outcomes among PLWH, especially those from disadvantaged subgroups. Our study goal is aligned with the Office of AIDS Research's and National Institute of Mental Health's research priorities in terms of social sciences studies and health disparities reduction. The proposed study will leverage existing NIH investment, capitalize on a rapid understanding of mental health needs among PLWH, stimulate additional collaborations with the All of Us program, and promote the translation of All of Us data to public health implications. The experience and preliminary data obtained from this supplement will position us for further efforts in utilizing All of Us data to improve mental and other health outcomes of PLWH in the US.", "keywords": [ "Acquired Immunodeficiency Syndrome", "Address", "Affect", "Age-Years", "Aging", "All of Us Research Program", "Anxiety", "Anxiety Disorders", "COVID-19", "COVID-19 impact", "COVID-19 outbreak", "COVID-19 pandemic", "COVID-19 pandemic effects", "COVID-19 vaccination", "Caring", "Chronic Disease", "Code", "Collaborations", "Complement", "Complex", "Data", "Data Analyses", "Data Science", "Diabetes Mellitus", "Diagnosis", "Disadvantaged", "Education", "Electronic Health Record", "Ethnic Origin", "Financial Hardship", "Fostering", "Fright", "Gender Identity", "Goals", "HIV", "Health", "Health Promotion", "Health Services Accessibility", "High Prevalence", "Hypertension", "Immune system", "Impairment", "Income", "Individual", "International Statistical Classification of Diseases and Related Health Problems Tenth Revision (ICD-10)", "Intervention", "Investments", "Knowledge", "Loneliness", "Low income", "Lung diseases", "Measures", "Mental Health", "Mental disorders", "Mental health promotion", "Mood Disorders", "National Institute of Mental Health", "Outcome", "Participant", "Patient Self-Report", "Pattern", "Personal Satisfaction", "Personality Disorders", "Persons", "Population", "Positioning Attribute", "Prevention", "Psyche structure", "Public Health", "Race", "Reduce health disparities", "Research", "Research Priority", "Risk Factors", "SARS-CoV-2 infection", "Sample Size", "Schizophrenia", "Series", "Services", "Sexual and Gender Minorities", "Social Identification", "Social Sciences", "Social support", "Stigmatization", "Stress", "Subgroup", "Substance Use Disorder", "Surveys", "Symptoms", "Testing", "Translations", "United States", "United States National Institutes of Health", "Vulnerable Populations", "base", "cloud based", "cohort", "comorbidity", "design", "disparity reduction", "effective intervention", "ethnic minority", "experience", "health assessment", "health disparity", "high risk", "improved", "large scale data", "multiple datasets", "negative affect", "pandemic disease", "parent grant", "parent project", "programs", "protective factors", "psychologic", "psychosocial wellbeing", "public health emergency", "racial and ethnic", "recruit", "resilience", "response", "sexual identity", "social disadvantage", "social stigma", "socioeconomic disadvantage", "stress related disorder", "theories", "trend" ], "approved": true } }, { "type": "Grant", "id": "10500", "attributes": { "award_id": "75N93022C00048-0-9999-1", "title": "SYSTEMATIC UNDERSTANDING AND ELIMINATION OF MISINFORMATION ONLINE", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2022-08-08", "end_date": "2023-08-07", "award_amount": 299964, "principal_investigator": { "id": 26506, "first_name": "JAMES", "last_name": "NOLAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1579, "ror": "", "name": "GRYPHON SCIENTIFIC, LLC", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "To develop digital tools to identify and combat malicious digital bots that spread misinformation about infectious disease treatments and vaccines, including COVID-19 vaccines.", "keywords": [ "2019-nCoV", "Basic Science", "COVID-19 vaccine", "Coronavirus", "Misinformation", "Vaccines", "combat", "digital", "infectious disease treatment", "tool" ], "approved": true } }, { "type": "Grant", "id": "10501", "attributes": { "award_id": "1F30AI167524-01A1", "title": "Longitudinal mucosal immune response to SARS-CoV-2 starting prior to infection", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 26420, "first_name": "MARY KATHERINE", "last_name": "Bradford", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-01", "end_date": "2025-07-31", "award_amount": 51752, "principal_investigator": { "id": 26507, "first_name": "Alexander", "last_name": "Viloria Winnett", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 211, "ror": "https://ror.org/05dxps055", "name": "California Institute of Technology", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Morbidity and mortality in COVID-19 is the result of an exaggerated inflammatory response causing severe tissue and organ damage. However, the biological mechanism for why some individuals progress from initially stable to ultimately critical condition has not been fully elucidated. This work proposes that the immune response at the site of infection during the earliest stage of infection plays a deterministic role on subsequent pathology; namely that a delayed or suppressed type 1 interferon response in the respiratory mucosa within the first few days of infection permits rapid viral proliferation with minor symptoms, but eventually leads to the high viral loads and exaggerated inflammatory response seen later in disease. Further, the proposed project will test whether a delayed interferon response is the result of previously documented age-related dysfunction. It also seeks to determine whether direct SARS-CoV-2 mediated disruption of host splicing can also suppress interferon signaling in the early stage of infection. To do this, the study will leverage a unique set of longitudinal paired nasal swab and saliva samples from individuals who are initially negative for SARS-CoV-2 infection, but become infected while being prospectively sampled with high frequency (twice per day) as part of an IRB-approved (#20- 1026) COVID-19 household transmission study that the applicant co-designed and co-leads (since August 2020) at the California Institute of Technology. The transcriptome present in these samples will be analyzed to measure gene and isoform expression from which leukocyte recruitment and activation, including through interferon signaling can be inferred, through the elusive early stage of infection and the full course of the illness. Longitudinal differential expression and differential splicing paths in patients as young as age 6, and of advanced age will be assessed to identify whether age-related differences in immune response (in particular, interferon signaling) lead to more rapid increases in viral load, and subsequent symptom severity. In addition, from an RNA sequencing library enriched for nascent pre-mRNAs, splicing defects such as intron retention will be measured, to identify whether virus-mediated disruption of splicing also leads to a suppressed or delayed early interferon response permissive of rapid viral proliferation. COVID-19 is a public health threat, and in line with the mission of the NIAID, the results of this study can provide mechanistic insights into the pathophysiology of SARS-CoV-2 infection, to potentially identify novel or more efficient targets for the prevention or treatment of severe disease. In addition, the proposed project offers an excellent training opportunity for the applicant to gain knowledge and skills in immunology, virology/coronavirus biology, mechanisms of human RNA splicing, and generation analysis and interpretation of RNA sequencing data, with mentorship from Dr. Rustem Ismagilov, Dr. Akiko Iwasaki, and Dr. Mitch Guttman, who are experts in the aforementioned fields.", "keywords": [ "2019-nCoV", "Accounting", "Acute", "Adult", "Age", "Antiviral Response", "Autopsy", "Biological", "Biology", "COVID-19", "California", "Cell Culture Techniques", "Characteristics", "Child", "Clinical", "Collaborations", "Coronavirus", "Data", "Data Set", "Defect", "Development", "Disease", "Disease Progression", "Elderly", "Enrollment", "Frequencies", "Functional disorder", "Generations", "Genes", "Genetic Transcription", "Household", "Human", "Immune", "Immune System Diseases", "Immune response", "Immunobiology", "Immunology", "Individual", "Infection", "Inflammatory", "Inflammatory Response", "Influenza", "Institutes", "Institutional Review Boards", "Interferon Suppression", "Interferon Type II", "Interferons", "Introns", "Kinetics", "Knowledge", "Laboratories", "Lead", "Leukocytes", "Libraries", "Measurement", "Measures", "Mediating", "Mentorship", "Messenger RNA", "Minor", "Mission", "Morbidity - disease rate", "Mucosal Immune Responses", "Mucous Membrane", "National Institute of Allergy and Infectious Disease", "Nonsense-Mediated Decay", "Nonstructural Protein", "Nucleic Acids", "Obesity", "Ontology", "Organ", "Pathology", "Pathway interactions", "Patients", "Phase", "Play", "Prevention", "Prophylactic treatment", "Protein Isoforms", "Public Health", "RNA Splicing", "Research Project Grants", "Respiratory Mucosa", "Risk Factors", "Role", "SARS-CoV-2 infection", "SARS-CoV-2 negative", "Saliva", "Sampling", "Severities", "Severity of illness", "Signal Transduction", "Site", "Specimen", "Symptoms", "Technology", "Testing", "Tissue Sample", "Tissues", "Transcript", "Translations", "Treatment Effectiveness", "Viral", "Viral Load result", "Viral load measurement", "Virus", "Work", "acute infection", "age related", "computerized tools", "design", "differential expression", "high risk", "immunoregulation", "insight", "interest", "mRNA Precursor", "mRNA sequencing", "mortality", "nasal swab", "novel", "prospective", "protein transport", "recruit", "repository", "respiratory", "response", "saliva sample", "severe COVID-19", "skills", "temporal measurement", "therapeutic target", "training opportunity", "transcriptome", "transcriptome sequencing", "transcriptomics", "transmission process", "virology" ], "approved": true } }, { "type": "Grant", "id": "10502", "attributes": { "award_id": "3U01HD094658-05S2", "title": "IMPROVING COVID-19 VACCINATION UPTAKE IN HIV POSITIVE PREGNANT WOMEN IN NIGERIA", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6835, "first_name": "Denise", "last_name": "Russo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2023-06-30", "award_amount": 142199, "principal_investigator": { "id": 22793, "first_name": "Alash'le G.", "last_name": "Abimiku", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true }, "abstract": "A. Project Summary/Abstract With the current global devastation and loss of lives, livelihood, and share suffering as a result of the COVID-19 pandemic, especially with the weak health care systems and limited resources in Africa, there is need to conduct research that will provide valuable information on treatment and prevention options and to understand the peculiarities of different populations as they respond. The effective COVID-19 vaccines have been largely instrumental to success in fighting the pandemic in the last 18 months. While most countries in the developed world have vaccinated over 70% of their population, only 21 African countries have fully vaccinated between 10% and 19% of their populations. Nigeria has only vaccinated 7.2% of its adult population and boosted only 0.4% and there is currently no data of vaccination in pregnant women or HIV infected persons. Even with the improved access of vaccines to Africa, vaccine hesitancy continues to limit the ability to improve vaccine coverage in these countries. Our ongoing NIH funded BEAMING grant (5U01HD094658) situated at a tertiary hospital where we have conducted research for over 20 years and including two prospective natural history birth cohort studies in HIV is uniquely placed to rapidly provide information for the first time from this part of the world that is this vulnerable population. This supplemental submission builds on the BEAMING experience and infrastructure to address research questions of great public health importance on social and culture norms that could explain vaccine hesitancy in this vulnerable population. We plan to use the information to develop culturally and socially acceptable educational materials and sessions that target drivers of vaccine hesitancy in HIV pregnant women and their matched uninfected pregnant controls in Nigeria, with the objective of re-shaping policies and strategies towards improved COVID-19 vaccines uptake in preparation for other waves of SARS COV-2 or future pandemics through three specific aims. Aim 1 will document social and cultural reasons for COVID-19 vaccine hesitancy among pregnant women in Nigeria and whether HIV infection creates an additional layer of burden. Aim 2 will develop strategies and educational materials to improve COVID-19 vaccine hesitancy and coverage in this population based on responses obtained from Aim 1. Aim 3 will document for the presence of anti- SARS-CoV-2 antibodies in infected pregnant women with or without HIV-1 infection; and if possible, the presence of anti- SARS-CoV-2 passively transferred antibodies in their infants.", "keywords": [ "2019-nCoV", "Address", "Adult", "Affect", "Africa", "African", "Birth History", "COVID-19", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Cohort Studies", "Country", "Data", "Decision Making", "Developing Countries", "Education", "Educational Materials", "Focus Groups", "Funding", "Future", "Grant", "Guidelines", "HIV", "HIV Infections", "HIV Seropositivity", "HIV-1", "Healthcare Systems", "Hospitals", "Immune response", "Improve Access", "Infant", "Infection", "Infrastructure", "Interviewer", "Literature", "Mothers", "Natural History", "Nigeria", "Nigerian", "Normalcy", "Passive Transfer of Immunity", "Persons", "Policies", "Policy Maker", "Population", "Pregnant Women", "Preparation", "Prevalence", "Prevention", "Public Health", "Questionnaires", "Research", "Resources", "SARS-CoV-2 antibody", "Shapes", "Soldier", "Structure", "Testing", "Time", "Travel", "United States National Institutes of Health", "Vaccinated", "Vaccination", "Vaccines", "Vulnerable Populations", "Woman", "base", "design", "experience", "fighting", "improved", "insight", "pandemic disease", "population based", "pregnant", "prospective", "response", "social", "social culture", "success", "unvaccinated", "vaccine acceptance", "vaccine access", "vaccine hesitancy" ], "approved": true } }, { "type": "Grant", "id": "10503", "attributes": { "award_id": "3U24HG007008-09S1", "title": "Institute of Human Virology H3Africa Biorepository (I-HAB) ADMIN SUPPLEMENT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Human Genome Research Institute (NHGRI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26498, "first_name": "Jennifer L", "last_name": "Troyer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-16", "end_date": "2023-06-30", "award_amount": 345798, "principal_investigator": { "id": 22793, "first_name": "Alash'le G.", "last_name": "Abimiku", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true }, "abstract": "The Institute of Human Virology Nigeria (IHVN) H3Africa biorepository (I-HAB), has successfully upgraded its practices to be ISBER compliant through an iterative quality assessment-based interaction involving capacity building drawing upon Coriell’s proven models and graduated to be the W/Africa H3Africa regional biorepository, During the COVID-19 pandemic, I-HAB lost 18 months of its planned activities due to the disruption of services by the pandemic. So far, I-HAB has only successfully received and aliquoted all DNA biospecimens from only one of the six H3Africa research projects that it supports. Two of the projects deposited 67% and 86% while the rest of the three projects are below 50% submission; at only 0%, 17%, and 29%. The goal of this administrative supplemental submission (1 JULY 2022 TO 30 JUNE 2023) is to ensure that all remaining biospecimens are deposited by H3Africa investigators, aliquoted, and used in the final phase which is to distribute aliquoted biospecimens and data to investigators from the wider scientific community whose application has been approved by the Data and Biospecimen Advisory Committee (DBAC) to conduct high-quality genomics and translational research in Africa using well processed, preserved and quality controlled and redundantly protected human biological samples. To achieve this, I-HAB builds on its past successes to address four specific aims. 1) Engage PIs to complete deposition and create sub-aliquots of primary human biologic samples and genetic materials in compliance with GLP, ISBER guidelines, and QC 10% in line with H3Africa policies/ guidelines. 2) Populate, interrogate, and query the database regularly to ensure that the online catalogue is up to date, interfacing regularly with other two regional H3Africa biorepositories, the H3AfricaBionet team, and relevant stakeholders to review and brainstorm on ways to address gaps during scheduled meetings. 3) Pilot processes for efficient distribution of high- quality biological samples to the wider scientific community, based on Data and Biological samples Access Committee approval and according to H3Africa policies and guidelines. 4) Strengthen I-HAB’s business model as part of a long-term sustainability strategy. Working collaboratively with the other two sister H3Africa biorepositories and the H3Africa Bionet, I-HAB continues to advocate for host government and community support and pilot processes to make the regulatory and ethical process of sharing samples and data easier. The strong institutional support through the expansion of the biorepository to over 3times its size at IHVN’s new facility, the acquirement of a liquid nitrogen plant, and the expansion of its clientele to investigators outside of H3Africa signals a sustainable future for I- HAB.", "keywords": [ "Address", "Administrative Supplement", "Advisory Committees", "Advocate", "Africa", "African", "Aliquot", "Bioinformatics", "Biological", "Businesses", "COVID-19 pandemic", "Catalogs", "Clinical Data", "Communities", "DNA", "Data", "Deposition", "Disease", "Ensure", "Ethics", "Future", "Genes", "Genetic Materials", "Genomics", "Goals", "Government", "Grant", "Guidelines", "Health", "Human", "Human Resources", "Infrastructure", "Institutes", "Leadership", "Liquid substance", "Mentors", "Modeling", "Nigeria", "Nitrogen", "Persons", "Phase", "Plants", "Policies", "Population", "Process", "Public Health", "Race", "Research", "Research Personnel", "Research Project Grants", "Resources", "Rest", "Sampling", "Schedule", "Science", "Scientist", "Services", "Shipping", "Signal Transduction", "Sister", "Time", "Training", "Translational Research", "Work", "base", "biobank", "clinical research site", "database query", "epidemiologic data", "global health", "high standard", "improved", "meetings", "pandemic disease", "preservation", "sample collection", "success", "virology" ], "approved": true } }, { "type": "Grant", "id": "10504", "attributes": { "award_id": "3U01HD094658-05S1", "title": "Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING) ADMINISTRATIVE SUPPLEMENT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6835, "first_name": "Denise", "last_name": "Russo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2023-06-30", "award_amount": 104214, "principal_investigator": { "id": 22793, "first_name": "Alash'le G.", "last_name": "Abimiku", "orcid": null, "emails": "[email protected]", "private_emails": null, "keywords": "[]", "approved": true, "websites": "[]", "desired_collaboration": "", "comments": "", "affiliations": [ { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1539, "ror": "https://ror.org/02e66xy22", "name": "Institute of Human Virology", "address": "", "city": "", "state": "", "zip": "", "country": "NIGERIA", "approved": true }, "abstract": "Understanding microbial shifts and how they affect vaccine response is central to this study. We will determine if gut microbial communities associated with breastfeeding in the HEU infant follows the same successional trajectory as HU controls and resolve the differences at functional level. How the continuous conditioning of the infant gut by the microbiota from the breast milk affects the infant microbiome and subsequent immune responses to pediatric vaccination is not known and would also be studied in this submission. Teasing out possible humoral vaccine differences due to HLA associations will be an important component to consider when identifying the mechanism and impact of microbial ecological conditioning through the breast milk towards vaccine responsiveness. Our submission proposes to use biological samples collected at regular intervals over a 12-month period from a multi-site study of well characterized cohort of mother: infant pairs of HEU and HU controls from Nigeria and South Africa to investigate both host and microbial genetic determinants of altered immunity in African infants. However, the COVID-19 pandemic that hit in 2021 however disrupted our work for about 18 months since the laboratories were closed under lockdown in addition to challenges due to hike in cost of laboratory consumables and reagents, delay and cancellation of shipments, and loss of man hours due to ill health of staff and family members due to COVID-19. Our administrative supplemental submission is to request for an extension from 1 July 2023 to 30 June 2023 to continue to investigate microbial shifts and how they affect growth and immune response to pediatric vaccines in HEU infants as compared to matched HU controls. Our hypothesis is that breast milk microbiota conditioning in newborn infants impacts growth and immune responsiveness to pediatric vaccines in the context of inherited HLA variants. We will continue to test our hypothesis through the same specific aims: Aim 1: Compare the ontogeny of microbial structure and metabolome in longitudinal breast milk and stool samples of corresponding 200 Exclusively Breast Fed (EBF) HEU versus 100 EBF HU control, infants over the first 12 months of life to document influence of the milk microbiota on the infant gut microbiome; and their collective effect or association with growth. Aim 2: Assess the relationship between infant microbial structure and humoral immune responses to pediatric vaccines AIM 3: To associate inherited HLA gene variants with humoral immune responses to pediatric vaccines in the two infant groups. This proposal will interrogate both host and microbial genetic determinants of altered immunity in HEU and is therefore highly relevant and responsive to the original RFA RM16-013.", "keywords": [ "Administrative Supplement", "Affect", "African", "Alleles", "Antibody titer measurement", "Antigens", "Biological", "Breast Feeding", "CD8-Positive T-Lymphocytes", "COVID-19", "COVID-19 pandemic", "Child", "Childhood", "Country", "Data", "Exclusive Breastfeeding", "Family member", "Genes", "Genetic Determinism", "Grant", "Growth", "HIV", "HIV-exposed uninfected infant", "Health", "Hour", "Human Milk", "Immune", "Immune response", "Immunity", "Infant", "Inherited", "Laboratories", "Life", "Microbial Genetics", "Milk", "Mothers", "Newborn Infant", "Nigeria", "Play", "Population", "Process", "Reagent", "Role", "Sampling", "Ships", "Site", "South Africa", "Specimen", "Structure", "Testing", "Time", "Vaccination", "Vaccines", "Variant", "Work", "base", "cohort", "conditioning", "coronavirus disease", "cost", "experience", "genetic variant", "gut bacteria", "gut microbiota", "infant gut microbiome", "insight", "man", "metabolome", "microbial", "microbiome", "microbiota", "stool sample", "vaccine response", "vaccine-induced antibodies" ], "approved": true } }, { "type": "Grant", "id": "10506", "attributes": { "award_id": "1R56HL158730-01A1", "title": "Investigate the mechanism and impact of E-cigarettes on platelet function and thrombogenesis", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26431, "first_name": "Yu-Chung", "last_name": "Yang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-20", "end_date": "2023-08-31", "award_amount": 534874, "principal_investigator": { "id": 26510, "first_name": "Fatima Z.", "last_name": "Alshbool", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1643, "ror": "", "name": "TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "While smoking has been on the decline, e-cigarette usage has been on the rise, even during the COVID19 pandemic. Furthermore, even though the contribution of traditional smoking to the pathogenesis of thrombotic diseases is well documented, the involvement of e-cigarettes in such disease processes remains unknown. Consequently, the present application outlines studies that address fundamental, mechanistic, and clinically- relevant translational aspects of the adverse-health effects of e-cigarettes, an increasingly popular form of tobacco, in the context of platelet biology, thrombotic disease and sex, and in a device-, and e-liquid-specific manner. Studies are also proposed to investigate, in a similar fashion, the toxicants that underlie e-cigarette effects. These studies are of paramount significance given the “perceived safety” of e-cigarettes. The Aims of this proposal are: Aim 1. Investigate the impact of e-cigarette exposure on platelet-dependent disease states. While there is compelling evidence that e-cigarettes do exert negative health effects, their impact on platelet-dependent diseases is still unknown. To address these issues, the consequences of e-cigarette exposure on normal hemostasis be will determined, in a dose-, and time-dependent fashion. Subsequent studies will examine whether e-cigarettes participate in the development of thrombosis disease. Finally, experiments are designed in a manner that addresses the role of the device, and e-liquid in e-cigarette effects, with sex as a biological variable. Aim 2. Investigate the mechanism by which e-cigarettes modulate platelet function. Even though the preliminary data indicated that e-cigarettes modulate hemostasis, the mechanism, by which they modulate platelet function remains to be investigated. Thus, the overall goal of the experiments proposed in this section is to determine the impact of e-cigarette exposure on the various platelet functional responses, biochemical/plasma “markers” of thrombosis, the mechanistic resistance to PGI2, and whether the effects are receptor mediated. Finally, studies are proposed to determine if e-cigarettes modulate the platelet miRnome. Aim 3. Define e-cigarettes toxicants with potent impact on platelet-dependent disease and function. While e-cigarettes are known to be source of a large number of toxicants, such as cotinine and acrolein, nothing is known regarding their specific impact on platelet activation/disease. Therefore, the effect of the e-cigarette toxicants, alone or in combination, on platelet function and associated disease will be investigated. Collectively, these experiments will make significant contributions to the understanding of the consequences of e-cigarettes on platelet activation and cardiovascular human health, and the mechanism and toxicants by/through which they exert these effects, in a dose-, time-, device-, e-liquid- specific manner, in the context of sex.", "keywords": [ "Acrolein", "Address", "Agonist", "Animal Diseases", "Animal Model", "Awareness", "Behavior", "Biochemical", "Biochemical Markers", "Biological", "Biology", "Blood", "Blood Coagulation Factor", "Blood Platelets", "COVID-19 pandemic", "Cardiovascular Diseases", "Cardiovascular system", "Clot retraction", "Cotinine", "Data", "Dependence", "Development", "Devices", "Disease", "Dose", "Electronic cigarette", "Elements", "Epoprostenol", "Exposure to", "Foundations", "Goals", "Health", "Hemostatic function", "Human", "JUUL", "Life", "Mediating", "Morbidity - disease rate", "Mus", "Nature", "Nicotine", "Pathogenesis", "Perception", "Pharmacology", "Physiological", "Plasma", "Platelet Activation", "Play", "Policies", "Prevention", "Process", "Public Health", "Research Design", "Resistance", "Risk", "Role", "Safety", "Shapes", "Smoking", "Source", "Stimulus", "System", "Therapeutic", "Thrombosis", "Thrombus", "Time", "Tobacco", "Tobacco Industry", "Tobacco smoking behavior", "Tobacco use", "Toxic effect", "United States", "base", "biological systems", "cardiovascular disorder risk", "cardiovascular health", "clinically relevant", "design", "electronic cigarette use", "electronic cigarette user", "electronic liquid", "evidence base", "experimental study", "mortality", "mouse model", "platelet function", "receptor", "response", "sex", "thrombogenesis", "tobacco control", "tobacco toxicant", "toxicant", "vaping" ], "approved": true } }, { "type": "Grant", "id": "10509", "attributes": { "award_id": "1R15HD109791-01", "title": "The Patient Journey for Children with Medical Complexity during Pandemic Era andits implications.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 26514, "first_name": "Tammara L", "last_name": "Jenkins", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-14", "end_date": "2024-08-31", "award_amount": 489163, "principal_investigator": { "id": 26515, "first_name": "Onur", "last_name": "Asan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1113, "ror": "https://ror.org/02z43xh36", "name": "Stevens Institute of Technology", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "CMC are a small proportion of children and youth with special health care needs that account for less than 1-5% of all children but consume over one third of health care resources. They are at increased risk of multiple and prolonged hospitalizations, inefficient use of healthcare resources, frequent medical errors, poor health outcomes, significant unmet needs for health services, and stress on family caregivers. This complexity and related problems have been and continue to be even further exacerbated by the COVID pandemic. The rise of the novel coronavirus (COVID-19) changed dynamics and contributed to a paradigm shift in the overall health care practice which will probably have long lasting impact and may be the “new normal”. In this exploratory study, our overarching goal is to understand how COVID-19 Pandemic impacted CMC care patient journey. We will capture the experience of multi stakeholders associated with CMC care including hospitalists, pediatrics outpatient providers, home nurses, CMC caregivers and patients. The findings will help the ongoing efforts to redesign and improve CMC care especially in the light of new challenges introduced by the COVID-19 Pandemic. The aims of the project are to: 1) Perform a multi-stakeholder 360-degree analysis of the COVID experience for CMC patients across different settings in their patient journey using qualitative and human factors techniques. 2) Quantitatively evaluate usefulness and experience of Telehealth use in CMC care, and 3) Evaluate the impact of pandemic on health outcome/utilization CMC using retrospective chart review. The research team is well positioned to address the proposed aims for the CMC population and thus guide identification of potential interventions to improve CMC care. This innovative, in-depth, and rich analysis of the CMC care patient journey during the pandemic using novel human factors methodologies will provide highly valuable information, not only for CMC, but also for other similarly complex care settings and patient populations.", "keywords": [ "Academy", "Activities of Daily Living", "Address", "Ambulatory Care Facilities", "American", "Apnea", "Behavioral", "COVID-19", "COVID-19 pandemic", "COVID-19 pandemic effects", "Caregivers", "Caring", "Categories", "Child", "Child Care", "Childhood", "Chronic", "Clinic", "Cognitive", "Complex", "Consumption", "Data", "Data Analyses", "Data Collection", "Development", "Effectiveness", "Emergency department visit", "Emotional", "Environment", "Ethnic Origin", "Exposure to", "Family Caregiver", "Future", "Goals", "Health", "Health Care Research", "Health Services Needs", "Healthcare", "Home", "Hospitalists", "Hospitalization", "Human", "Inpatients", "Institutes", "Intervention", "Intervention Studies", "Laws", "Mechanical ventilation", "Medical", "Medical Errors", "Medical center", "Methodology", "Monitor", "Multicenter Studies", "New Jersey", "Nurses", "Only Child", "Outcome", "Outpatients", "Output", "Parents", "Patient Care", "Patients", "Pediatric Hospitals", "Pediatrics", "Persons", "Physiological", "Population", "Positioning Attribute", "Provider", "Recommendation", "Records", "Research", "Resources", "Risk", "Schools", "Social Distance", "Specialist", "Stress", "Students", "Surveys", "Techniques", "Technology", "Visit", "Vulnerable Populations", "care delivery", "clinical care", "coronavirus disease", "demographics", "experience", "graduate student", "health care service", "high risk", "high risk population", "improved", "innovation", "inpatient service", "lens", "medical delivery system", "medical specialties", "medical vulnerability", "member", "novel", "novel coronavirus", "pandemic disease", "patient home care", "patient population", "pediatric patients", "resilience", "social", "telehealth", "undergraduate student", "virtual healthcare", "virtual visit" ], "approved": true } }, { "type": "Grant", "id": "10510", "attributes": { "award_id": "1F31AG077931-01", "title": "Impacts of SARS-CoV-2 Infection and Age on Musculoskeletal Health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8478, "first_name": "John", "last_name": "Williams", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-01", "end_date": "2025-08-31", "award_amount": 39019, "principal_investigator": { "id": 26516, "first_name": "Olatundun", "last_name": "Awosanya", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1621, "ror": "", "name": "INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic as of June 14, 2021, has totaled 176.02 million cases, 3.80 million deaths, and 2.37 billion vaccine doses have been administered globally. However, many have suffered prior to the vaccine and have survived or will still suffer without the vaccine. Therefore, determining the possible long-term health ramifications post-infection, how they vary based on age at the time of infection, and whether disease severity differentially impacts long-term health is imperative. Information on how COVID-19 affects bone metabolism and homeostasis is limited. This is of crucial concern because the aging population generally has higher bone loss and are at the highest risk of developing severe COVID-19 infection. The objective of the current application is to determine whether long-term deficits in bone mass are experienced following SARS-CoV-2 infection. The long-term goal is to develop potential treatment strategies to combat COVID-19 related bone loss. Preliminary studies showed that in a K18-hACE2 mouse model of COVID-19, surviving mice infected with 1x103 or 1x104 PFU exhibited up to a 24% reduction in trabecular bone volume fraction just 2 weeks post infection (p<0.001). Infected mice had a 63% increase in osteoclast numbers (p<0.0002) and a 30% increase in surface occupied by osteoclasts (p<0.02) compared to non-infected controls. Additionally, mice infected with any dose of SARS-CoV-2 had a 40% increase in megakaryocytes (MKs) within their femoral bone marrow compared to that observed in mock-infected controls (p<0.008). Further, previously conducted studies showed that MKs regulate bone mass and osteoclast (OC) formation (aged MKs increase OCs and have increased RANKL expression). Moreover, patients with severe forms of COVID-19 have upregulated expression of numerous cytokines and growth factors which is known as an inflammatory cytokine storm. Many of these cytokines, including IL-6 and TNF-α, are known to regulate OCs and/or MKs and may be responsible for the bone loss observed in the preliminary studies. Based on these observations it is hypothesized that i) SARS-CoV-2 infection results in long-term health complications in the musculoskeletal system, and ii) SARS-CoV-2 infection and the associated cytokine storm increases MK- stimulated OC formation. To test this hypothesis, two specific aims will be pursued: 1- determine whether following SARS-CoV-2 infection the bone loss observed remains over time and whether age at the time of infection impacts the severity of bone loss induced by SARS-CoV-2 infection, and: 2- investigate the mechanisms by which OC formation and bone resorption are increased as a consequence of SARS-CoV-2 infection and age, including the extent to which MKs from infected mice induce OC formation and bone resorption. The successful completion of these studies will deepen the understanding of the health implications post-infection with SARS-COV-2 and will demonstrate how disease severity, age, and MKs influence skeletal homeostasis as well as OC formation and resorption.", "keywords": [ "2019-nCoV", "Age", "Age-Months", "Area", "Autopsy", "Blood Platelets", "Body Weight", "Bone Marrow", "Bone Resorption", "Brain", "COVID-19", "COVID-19 complications", "COVID-19 impact", "COVID-19 pandemic", "COVID-19 patient", "COVID-19 severity", "CXCL10 gene", "Cardiac", "Cells", "Cessation of life", "Clinical", "Conditioned Culture Media", "Contracts", "Data", "Disease", "Disease model", "Dose", "Elderly", "Epidemic", "Exhibits", "General Population", "Goals", "Growth Factor", "Health", "Heart", "Histologic", "Homeostasis", "Human body", "Infection", "Inflammatory", "Interleukin-1 beta", "Interleukin-17", "Interleukin-6", "K-18 conjugate", "Laboratories", "Lead", "Light", "Lung", "Megakaryocytes", "Monitor", "Mus", "Musculoskeletal", "Musculoskeletal System", "OSTF1 gene", "Organ", "Osteitis", "Osteoclasts", "Osteoporosis", "Patients", "Platelet Count measurement", "Population", "Posture", "Reporting", "SARS-CoV-2 infection", "SARS-CoV-2 negative", "Serum", "Severities", "Severity of illness", "Skeleton", "Surface", "System", "TNF gene", "TNFSF11 gene", "Testing", "Thrombophilia", "Thrombopoietin", "Thrombus", "Time", "Transgenic Mice", "Vaccines", "Viral Load result", "aged", "aging population", "base", "body system", "bone", "bone loss", "bone mass", "bone metabolism", "bone turnover", "cohort", "combat", "cytokine", "cytokine release syndrome", "experience", "high risk", "mortality", "mouse model", "osteoclast progenitor", "post SARS-CoV-2 infection", "severe COVID-19", "skeletal", "substantia spongiosa", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "10511", "attributes": { "award_id": "1U01CK000671-01", "title": "Midwest Virtual Laboratory of Pathogen Transmission in Healthcare Settings (MVL-PATHS)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2022-09-30", "end_date": "2025-09-29", "award_amount": 299761, "principal_investigator": { "id": 26517, "first_name": "Majid", "last_name": "Bani Yaghoub", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 753, "ror": "", "name": "UNIVERSITY OF MISSOURI KANSAS CITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "Midwest Virtual Laboratory of Pathogen Transmission in Healthcare Settings (MVL-PATHS) Project Summary Antimicrobial Resistant (AMR) pathogens have become a significant public health threat. Also, the COVID-19 pandemic has further revealed disparities in healthcare settings. By developing and implementing novel mathematical and computation models, the long-term goals are to optimize AMR control and preventive interventions and to improve the health equity. The central hypothesis is that the outputs of mathematical and computation models will provide optimized and effective guidelines to reduce the threat of AMR pathogen spread and reduce health disparities in healthcare settings. The rationale underlying this project is to fill the critical gap in modeling workforce capacity and develop a new generation of mathematical models for healthcare research. The central hypothesis will be tested by pursuing three specific aims to develop and employ a, (i) One Health modeling approach to understand the source, distribution and spread of AMR Enterobacteriaceae with a focus on Extended- spectrum beta-lactamase (ESBL)-producing E. coli, (ii) a novel Real-Time modeling approach to identify AMR pathogen transmission by asymptomatic spreaders and contaminated medical devices in hospitals, (iii) a novel Agent-Based Nested modeling approach to identify the effects of caregivers as vectors of disease spread, and effects of limited staffing and specialized care on equitable quality of care in nursing homes. We will pursue these aims using an innovative combination of mathematical and computational modeling techniques. These include both recently developed techniques of including human behavior in models and more-established techniques that have been applied very little to the study of health equity and AMR pathogen spread. The workforce development objectives of this proposal are to (i) enhance mathematical and computational modeling research capabilities of the public health workforce and (ii) increase the number of junior modeling professionals that are trained and experienced in modeling transmission of pathogens in healthcare settings partly incorporated with health disparities. The expected outcomes of this work are the successful training of five predoctoral fellows and creating a virtual laboratory of enhanced mathematical models to identify strategies for reducing the threat AMR pathogen spread and reducing health disparities. The results will have an important positive impact immediately because the virtual laboratory can also be used by healthcare professionals to further investigate the drivers of disease spread and estimate the relative benefits of multiple control and prevention strategies in a timely and cost-effective manner. In addition, the research outputs of this project will expand and strengthen national one-health efforts to combat resistance and will have a direct impact on CDC and its public health partners’ ability to reduce the costs, morbidity and mortality of healthcare associated infections.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1405, "count": 14046 } } }