Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1385&sort=-abstract
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-abstract", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=-abstract", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1386&sort=-abstract", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=-abstract" }, "data": [ { "type": "Grant", "id": "6972", "attributes": { "award_id": "5UH3DK114920-05", "title": "Spatial Metabolomics for Human Kidneys", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 20726, "first_name": "Cindy", "last_name": "Roy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-09-15", "end_date": "2022-06-30", "award_amount": 993136, "principal_investigator": { "id": 20727, "first_name": "Kumar", "last_name": "Sharma", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 748, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCIENCE CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 748, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCIENCE CENTER", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity and mortality in patients in the US. The overall objective of the proposed study is to establish untargeted and targeted spatial metabolomics analysis of tissues from normal and diseased kidneys to assess cellular metabolic states associated with healthy function, acute injury, chronic condition, and recovery. We will employ ultra-high resolving power imaging mass spectrometry (e.g., MALDI-FTICR-IMS) complemented with novel bioinformatics (e.g., METASPACE) for metabolite annotation and big data interrogation strategies to identify alterations of metabolism in diseased kidneys compared with normal ones. Our Tissue Interrogation Site will be a multi-disciplinary coordinated program composed of leadership in translational nephrology and imaging mass spectrometry at UCSD, outstanding facilities for multi-omics analysis at Pacific Northwest National Laboratories (PNNL), and bioinformatics for mass spectrometry imaging and 3-D reconstruction housed at European Molecular Biology Laboratories (EMBL). Three specific aims in each phase (i.e., UG3 and UH3) are proposed. In particular, we will establish an untargeted and targeted spatial metabolomics platforms for human kidney interrogation and develop an open bioinformatics platform for data interrogation, 3-D reconstruction, molecular interpretation and public sharing. In the UH3 phase, the untargeted and targeted platforms will be scaled up to improve metabolite coverage and develop key metabolic pathways for specific renal compartments in kidneys from individuals with AKI, CKD, and disease subgroups. Moreover, the bioinformatics platform will also be scaled up to establish 3D (a next-generation technology) metabolite-based maps of kidney structure in normal and diseased kidneys. A web-service SM-Kidney will be implemented as the online platform to have all the datasets and the results publicly sharable. We will contribute and collaborate with the Central Hub (CH) to integrate our service for the formation of a molecular kidney atlas. With strong collaborations among the key personnel from UCSD, PNNL, EMBL, and other universities, institutes, and industry partners, our multidisciplinary team will reach key milestones during both the UG3 and UH3 phases. Milestones include 1) the development of a comprehensive untargeted database of metabolite annotations in the normal human renal compartments, 2) targeted spatial metabolomics analysis for selected classes of metabolites and pathways, 3) methods and SOPs that meet rigorous QC standards for tissue procurement, initial processing and IMS with optical imaging and 4) providing the online service SM-Kidney with a graphical user interface to evalaute spatial metabolic profiles associated with kidney disease and pathogenesis. All protocols, samples, data, and metabolite atlas of normal, AKI, and CKD samples will be shared across the KPMP.", "keywords": [ "3-Dimensional", "Acute", "Acute Renal Failure with Renal Papillary Necrosis", "Anatomy", "Area", "Atlases", "Big Data", "Bioinformatics", "Biological Markers", "Blood", "California", "Cells", "Chronic", "Chronic Kidney Failure", "Collaborations", "Communities", "Complement", "Data", "Data Set", "Databases", "Development", "Diagnostic", "Disease", "Disease Progression", "European", "Fourier transform ion cyclotron resonance", "Goals", "Human", "Human Resources", "Image", "In Situ", "Individual", "Injury", "Institutes", "Kidney", "Kidney Diseases", "Knowledge", "Laboratories", "Leadership", "Maps", "Mass Spectrum Analysis", "Metabolic", "Metabolic Pathway", "Metabolism", "Methods", "Molecular", "Molecular Biology", "Morbidity - disease rate", "Nephrology", "Normal tissue morphology", "Pacific Northwest", "Pathogenesis", "Pathway interactions", "Patients", "Phase", "Phenotype", "Preventive", "Protocols documentation", "Recovery", "Resolution", "Sampling", "Services", "Site", "Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization", "Statistical Data Interpretation", "Structure", "Technology", "Therapeutic", "Tissue Procurements", "Tissues", "Translating", "Universities", "Urine", "base", "bioinformatics resource", "design", "disease heterogeneity", "disorder subtype", "graphical user interface", "high resolution imaging", "improved", "industry partner", "metabolic profile", "metabolomics", "mortality", "multidisciplinary", "multiple omics", "next generation", "novel", "optical imaging", "precision medicine", "prognostic", "programs", "reconstruction", "scale up", "small molecule", "ultra high resolution", "web services" ], "approved": true } }, { "type": "Grant", "id": "8239", "attributes": { "award_id": "1R01MH125798-01A1", "title": "The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 24064, "first_name": "Lori", "last_name": "Scott-Sheldon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-04-20", "end_date": "2026-02-28", "award_amount": 492353, "principal_investigator": { "id": 24065, "first_name": "Michael D", "last_name": "Sweat", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from published reports requires careful analysis. There are conflicting findings across studies. Metrics and study designs used across studies are typically inconsistent. Pooling results across studies also requires advanced statistical techniques. The state-of-the-art strategy to address these challenges is to use systematic reviews and meta-analyses to analyze and interpret the effects of interventions evidenced with research across multiple studies. In the prposed study we will conduct systematic reviews and meta- analyses on studies from LMIC that focus on behavioral, social, or structural interventions. There are three key areas we will analyze: (1) interventions designed to support linkage, retention, and adherence to ART and PrEP with a focus on modes of service delivery; (2) interventions that integrate non-HIV health issues with HIV- specific health issues; and (3) assessing the impact of the COVID-19 epidemic on HIV-related care and prevention in LMIC. In addition, we will add to our rigorous data extraction information on both the theoretical basis of the interventions under consideration, as well as data on the implementation characteristics of each intervention. Data extraction on implementation characteristics and theory will also be done retrospectively for all 435 studies we have previously reviewed and added to our data repository.", "keywords": [ "AIDS prevention", "Address", "Adherence", "Africa", "Appointment", "Area", "Attention", "Behavior", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Centers for Disease Control and Prevention (U.S.)", "Characteristics", "Client", "Code", "Collaborations", "Communities", "Conflict (Psychology)", "Consensus", "Cost Analysis", "Data", "Decentralization", "Development", "Effectiveness", "Government", "Grant", "Guidelines", "HIV", "Health", "Health Services Accessibility", "Home", "Information Retrieval", "Intervention", "Intervention Studies", "Investments", "Journals", "Lead", "Link", "Literature", "Maps", "Mental Health", "Meta-Analysis", "Methods", "Modeling", "Outcome", "Paper", "Participant", "Patients", "Peer Review", "Pharmaceutical Preparations", "Policies", "Population", "Prevention", "Public Health", "Publications", "Publishing", "Reaction", "Reporting", "Reproductive Health", "Research", "Research Design", "Resources", "Risk", "Role", "Scientist", "Services", "Sexual Health", "Shock", "Structure", "Techniques", "Time", "Training", "Training Programs", "Translational Research", "United States National Institutes of Health", "Update", "Ursidae Family", "Vaccines", "Work", "base", "commune", "cost effectiveness", "data repository", "evidence base", "experience", "implementation intervention", "improved", "innovation", "intervention effect", "low and middle-income countries", "mathematical model", "meetings", "pre-exposure prophylaxis", "programs", "prospective", "rapid growth", "repository", "service delivery", "social", "social structure", "success", "systematic review", "theories", "therapy design", "vaccine access" ], "approved": true } }, { "type": "Grant", "id": "8240", "attributes": { "award_id": "5R01MH125798-02", "title": "The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 24064, "first_name": "Lori", "last_name": "Scott-Sheldon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-04-20", "end_date": "2026-02-28", "award_amount": 437627, "principal_investigator": { "id": 24065, "first_name": "Michael D", "last_name": "Sweat", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1179, "ror": "https://ror.org/012jban78", "name": "Medical University of South Carolina", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from published reports requires careful analysis. There are conflicting findings across studies. Metrics and study designs used across studies are typically inconsistent. Pooling results across studies also requires advanced statistical techniques. The state-of-the-art strategy to address these challenges is to use systematic reviews and meta-analyses to analyze and interpret the effects of interventions evidenced with research across multiple studies. In the prposed study we will conduct systematic reviews and meta- analyses on studies from LMIC that focus on behavioral, social, or structural interventions. There are three key areas we will analyze: (1) interventions designed to support linkage, retention, and adherence to ART and PrEP with a focus on modes of service delivery; (2) interventions that integrate non-HIV health issues with HIV- specific health issues; and (3) assessing the impact of the COVID-19 epidemic on HIV-related care and prevention in LMIC. In addition, we will add to our rigorous data extraction information on both the theoretical basis of the interventions under consideration, as well as data on the implementation characteristics of each intervention. Data extraction on implementation characteristics and theory will also be done retrospectively for all 435 studies we have previously reviewed and added to our data repository.", "keywords": [ "AIDS prevention", "Address", "Adherence", "Africa", "Appointment", "Area", "Attention", "Behavior", "Behavioral", "COVID-19", "COVID-19 pandemic", "Caring", "Centers for Disease Control and Prevention (U.S.)", "Characteristics", "Client", "Code", "Collaborations", "Communities", "Conflict (Psychology)", "Consensus", "Cost Analysis", "Data", "Decentralization", "Development", "Effectiveness", "Government", "Grant", "Guidelines", "HIV", "Health", "Health Services Accessibility", "Home", "Information Retrieval", "Intervention", "Intervention Studies", "Investments", "Journals", "Lead", "Link", "Literature", "Maps", "Mental Health", "Meta-Analysis", "Methods", "Modeling", "Outcome", "Paper", "Participant", "Patients", "Peer Review", "Pharmaceutical Preparations", "Policies", "Population", "Prevention", "Public Health", "Publications", "Publishing", "Reaction", "Reporting", "Reproductive Health", "Research", "Research Design", "Resources", "Risk", "Role", "Scientist", "Services", "Sexual Health", "Shock", "Techniques", "Time", "Training", "Training Programs", "Translational Research", "United States National Institutes of Health", "Update", "Ursidae Family", "Vaccines", "Work", "base", "commune", "cost effectiveness", "data repository", "evidence base", "experience", "implementation intervention", "improved", "innovation", "intervention effect", "low and middle-income countries", "mathematical model", "meetings", "pre-exposure prophylaxis", "programs", "prospective", "rapid growth", "repository", "service delivery", "social", "social structure", "success", "systematic review", "theories", "therapy design", "vaccine access" ], "approved": true } }, { "type": "Grant", "id": "5522", "attributes": { "award_id": "3K01DA042950-04S1", "title": "Understanding Transitions from Vaping to Smoking Across Adolescence", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 19198, "first_name": "HEATHER L", "last_name": "KIMMEL", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-09-01", "end_date": "2022-08-31", "award_amount": 52740, "principal_investigator": { "id": 19199, "first_name": "Jessica Louise", "last_name": "Barrington-Trimis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT - Parent K01 Despite the proliferation of adolescent e-cigarette use (i.e., vaping) and evidence of associations of vaping with cigarette initiation, research on whether vaping increases the risk of progression to regular, dependent smoking patterns and on factors that underlie these risk pathways are scant. Consequently, there are limited data to guide interventions to protect the growing population of adolescent vapers from transitioning to smoking. We hypothesize that a pro-tobacco social environment (e.g., lower socioeconomic environment in which smoking may be more accepted, proximity to tobacco retailers, having friends who smoke) may amplify the risk of transition from vaping to regular smoking and dependence, particularly among youth with a positive sensory-pharmacological response to their initial vaping experience who may therefore be more inclined to experiment with other tobacco products. This project will leverage data from two ongoing longitudinal cohorts to study vaping as a predictor of risk of smoking progression and dependence in adolescents aged 14-20 (Pooled N~3700; Aim 1a) and the role of the social environment and early vaping experience as moderators of this risk pathway (Aim 1b); we will also examine whether these associations differ by gender and age (Aim 1c). In a parallel project, we will conduct qualitative interviews with youth in these cohorts to uncover novel factors that influence this transition (N=60; Aim 2). Results from Aims 1 and 2 will be used to generate a new psychological survey to assess a novel construct of `susceptibility to transition from vaping to smoking.' We will conduct an initial validation study in a subset of youth vapers from both cohorts (N=200; Aim 3). Findings will be informative in (1) elucidating the possible harms that vaping may pose to population health by increasing youth smoking, which is important to guide development of policies and regulation of youth vaping; and (2) guiding the development of prevention strategies to address the social environment and alter the vaping experience to mitigate the risk of smoking among the rapidly increasing population of vaping adolescents. I enter this project with strong quantitative skills as an epidemiologist and growing experience in tobacco research. This K01 is critical for me to develop expertise in areas that will support my long-term goals to become an independent multi-disciplinary investigator of the intersecting environmental and intrapersonal determinants of adolescent tobacco and other drug use. The training proposed will help me to develop expertise in a) adolescent developmental psychopathology of addiction, b) qualitative research methodologies, and c) survey design and psychometric testing of survey items, with mentorship to additionally refine my skills in application of my research to inform policy and prevention efforts. I have worked closely with my mentors (selected based on their expertise in each training area) to develop an ambitious but feasible training plan that incorporates expert mentoring, directed readings, coursework and seminars, scientific meetings, and continued development of manuscript and grant writing skills.", "keywords": [ "Address", "Administrative Supplement", "Adolescence", "Adolescent", "Affect", "Age", "Alcohol consumption", "Alcohols", "Anxiety", "Area", "Attenuated", "Buffers", "Businesses", "COVID diagnosis", "COVID-19", "COVID-19 pandemic", "California", "Cannabis", "Cigarette", "Contracts", "Data", "Data Collection", "Dependence", "Development", "Disease", "Drug usage", "Economics", "Employment", "Environment", "Epidemic", "Epidemiologist", "Ethnic Origin", "Event", "Family", "Frequencies", "Friends", "Fright", "Funding", "Future", "Gender", "Goals", "Grain", "Grant", "Home", "Incentives", "Income", "Individual", "Intervention", "Interview", "Loneliness", "Longitudinal cohort", "Manuscripts", "Measures", "Mental Depression", "Mental Health", "Mentors", "Mentorship", "National Institute of Drug Abuse", "Nicotine Dependence", "Opioid", "Parents", "Participant", "Pathway interactions", "Pattern", "Pharmaceutical Preparations", "Pharmacology", "Pharmacy facility", "Policies", "Population", "Positioning Attribute", "Predisposition", "Prevention", "Prevention strategy", "Prospective cohort study", "Psychometrics", "Psychopathology", "Public Health", "Qualitative Research", "Race", "Randomized", "Reading", "Regulation", "Relapse", "Reporting", "Research", "Research Methodology", "Research Personnel", "Risk", "Role", "Schools", "Sensory", "Smoke", "Smoking", "Social Distance", "Social Environment", "Social isolation", "Source", "Substance Use Disorder", "Surveys", "Testing", "Time", "Tobacco", "Training", "Transportation", "Universities", "Virus", "Work", "Writing", "Youth", "addiction", "aged", "alcohol use disorder", "base", "binge drinking", "burden of illness", "cigarette smoke", "cigarette smoking", "cohort", "coronavirus disease", "design", "development policy", "drinking", "drug use behavior", "electronic cigarette use", "experience", "experimental study", "follow-up", "food insecurity", "generalized anxiety", "meetings", "multidisciplinary", "novel", "pandemic disease", "population health", "prevent", "psychologic", "psychological stressor", "response", "secondary outcome", "skills", "smoking addiction", "social", "sociodemographic factors", "socioeconomics", "substance use", "therapy design", "tobacco products", "validation studies", "vaper", "vaping", "young adult" ], "approved": true } }, { "type": "Grant", "id": "11098", "attributes": { "award_id": "1R01DK133330-01A1", "title": "Covid-19 induced worsening of glomerular diseases", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 22545, "first_name": "KEVIN E", "last_name": "Chan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-03-15", "end_date": "2027-12-31", "award_amount": 347600, "principal_investigator": { "id": 27070, "first_name": "Camille Emilie Adeline", "last_name": "Mace", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 804, "ror": "https://ror.org/01j7c0b24", "name": "Rush University Medical Center", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract (max 30 lines): SARS-CoV-2 is a respiratory tract infection associated with an extensive cytokine storm. Focal and segmental glomerulosclerosis (FSGS) and diabetic nephropathy (DN) are established risk factors for COVID-19 complications. Whereas both diseases can be exacerbated under cytokine storm conditions, the effect of COVID- 19 associated cytokine storm on the course of established FSGS and DN is not clear. We expect FSGS and DN to be worsened after COVID-19 infection. Based on human observational data, we generated multiple cytokine cocktails to mimic the COVID-19 cytokine storm, and showed that they cause multisystem injury when injected in rodents at high dose (severe COVID-19 in patients), and worsen kidney injury at low dose (mild COVID-19 in patients). Studying the effect of COVID-19 cytokine storm in animal models of glomerular disease will allow a better understanding of the impact of COVID-19 on patient with existing disorders. Furthermore, neutralizing the cytokine storm could potentially improve the outcome of hospitalized COVID-19 patients and prevent worsening of kidney function by using a combination of receptor blockage and cytokine depletion In Specific Aim 1, the applicant will study worsening of glomerular disease and chronic kidney disease due to FSGS and DN after induction of COVID-19 like cytokine storm. In Specific Aim 2, the applicant will assess the impact of allergy pathway cytokines IL-4 and IL-13, and inflammatory pathway cytokine TNF-α, and chemokine CXCL5 released during COVID-19 respiratory infection on pre-existing glomerular diseases. In Specific Aim 3, the applicant will treat COVID-19 related worsening of glomerular disease and chronic kidney disease FSGS and DN by depletion or blockage of the cytokine storm.", "keywords": [ "2019-nCoV", "Acute", "Acute Renal Failure with Renal Papillary Necrosis", "Adriamycin PFS", "Albuminuria", "Animal Model", "Antibodies", "COVID-19", "COVID-19 complications", "COVID-19 cytokine storm", "COVID-19 diagnosis", "COVID-19 impact", "COVID-19 patient", "COVID-19 risk", "COVID-19 treatment", "CXCL5 gene", "Chronic Kidney Failure", "Clinical Research", "Complex", "Creatinine", "Data", "Diabetes Mellitus", "Diabetic Nephropathy", "Disease", "Disease Outcome", "Dose", "Endothelium", "Focal and Segmental Glomerulosclerosis", "Goals", "Heart Injuries", "Histology", "Hospitalization", "Human", "Hypersensitivity", "IL-13Ralpha1", "IL8RB gene", "Infection", "Inflammatory", "Injections", "Injury", "Injury to Kidney", "Interleukin-13", "Interleukin-4", "Kidney", "Kidney Diseases", "Knock-out", "Mediating", "Modeling", "Morphology", "Mus", "Obesity", "Pathway interactions", "Patients", "Persons", "Plasma", "Proteins", "Proteinuria", "Rattus", "Renal function", "Renal glomerular disease", "Respiratory Tract Infections", "Risk Factors", "Rodent", "Role", "SARS-CoV-2 infection", "Sepsis", "Serum", "Signal Pathway", "System", "Systemic disease", "TNF gene", "TNFRSF1A gene", "Therapeutic", "Vascular Endothelial Growth Factors", "World Health Organization", "acute liver injury", "chemokine", "coronavirus disease", "cytokine", "cytokine release syndrome", "db/db mouse", "diabetic rat", "improved", "improved outcome", "mortality", "novel therapeutic intervention", "older patient", "pandemic disease", "podocyte", "post SARS-CoV-2 infection", "prevent", "receptor", "severe COVID-19", "tumor" ], "approved": true } }, { "type": "Grant", "id": "15634", "attributes": { "award_id": "1R01DK141612-01", "title": "Hodgkin’s Lymphoma-induced Nephrotic Syndrome", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 22545, "first_name": "KEVIN E", "last_name": "Chan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-01-01", "end_date": "2029-11-30", "award_amount": 343650, "principal_investigator": { "id": 32136, "first_name": "Eduardo", "last_name": "Molina Jijon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 804, "ror": "https://ror.org/01j7c0b24", "name": "Rush University Medical Center", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT (max 30 lines) Hodgkin Lymphoma (HL) is a malignant condition most prevalent in adolescents and young adults (3 new cases per 100,000 individuals per year). About 0.5 to 1% of HL patients develop nephrotic syndrome (NS). Hodgkin Reed–Sternberg (HRS) cells, representing about 1% of the tumor bulk, release cytokines and soluble proteins into the circulation that may reach the kidney where they trigger the development of NS. Published evidence in literature shows the presence of a ZHX2 hypomorph (ZHX2hypo/hypo) state in the tumor in HL, and several HRS cell lines are also known to have a ZHX2hypo/hypo state. The PI recently showed that Rhinovirus cytokine storm cocktails, a model for common cold induced MCD relapse, induce glomerular injury and albuminuria selectively in ZHX2hypo/hypo BALB/cJ and Zhx2flox/flox; NPHS2 promoter cre+/+ mice. The PI showed that the ZHX2hypo/hypo state is a key genomic defect in Minimal Change Disease (MCD) and some Focal Segmental Glomerulosclerosis (FSGS) patients. Preliminary data generated by the PI show a ZHX2hypo/hypo state and the presence of the same insertion at Chr8: 122,533,694 in the L-1236 HRS cell line and in some patients with HL that develop NS. When this insertion found in HL patients is replicated in cultured human podocytes using CRISPR/Cas9 editing, it triggers a ZHX2hypo/hypo state. When cytokines and soluble proteins present in the supernatant of the L-1236 HL cell line are injected into ZHX2hypo/hypo state and control mice, they trigger development of albuminuria only in ZHX2hypo/hypo state mice. The PI generated a cytokine HL cocktail replicating the secreted cytokine and soluble proteins profile of L-1236 cells and successfully induced albuminuria only in ZHX2hypo/hypo state mice. The PI identified the threshold nephritogenic dose 1X of the HL cocktail that induces significant histological glomerular injury and albuminuria in ZHX2hypo/hypo state mice. Hypothesis: A combination of cytokines and soluble proteins released by HRS cells induce glomerular injury and albuminuria in ZHX2hypo/hypo mice to mimic HL related NS. Depleting selected cytokines or soluble proteins alone or in combination, with antibodies, will improve glomerular injury and albuminuria in HL. In Specific Aim 1, injection of HL cell supernatant or HL cytokine cocktail to replicate the phenomenon of HL- induced glomerular injury and albuminuria in ZHX2hypo/hypo mice. Cell signaling in CRISPR-edited ZHX2hypo/hypo human podocytes will be studied. The contribution of IL-4Rα and other identified major components of the cocktail will be investigated. In Specific Aim 2, xenotransplant of HRS cells into immunodeficient NSG mice in a ZHX2hypo/hypo background to develop a new rodent model of HL and study the development of NS. In Specific Aim 3, treatment of HL-related glomerular injury and albuminuria by anti-cytokines antibodies (single or in combination) or their receptors blockage (alternative strategy) will be assessed for therapeutic response in ZHX2hypo/hypo BALB/cJ mice injected with HL cocktail and the new tumor HL mice model.", "keywords": [ "Adolescent and Young Adult", "Albuminuria", "Antibodies", "B-Lymphocytes", "BALB/cJ Mouse", "Blood", "CCL17 gene", "CCL2 gene", "CRISPR/Cas technology", "CXCL10 gene", "CXCR3 gene", "Cell Line", "Cell Lineage", "Cell Nucleus", "Cells", "Chronic", "Circulation", "Clustered Regularly Interspaced Short Palindromic Repeats", "Common Cold", "Culture Media", "Data", "Defect", "Development", "Disease", "Dose", "Focal and Segmental Glomerulosclerosis", "Genetic", "Genomic DNA", "Genomics", "Histologic", "Hodgkin Disease", "Human", "IL6ST gene", "Inbred BALB C Mice", "Incidence", "Individual", "Injections", "Injury", "Integrins", "Intercellular adhesion molecule 1", "Interferon Type II", "Interleukin-13", "Interleukin-6", "Kidney", "Lesion", "Literature", "LoxP-flanked allele", "Lymphoma cell", "Malignant - descriptor", "Modeling", "Mus", "Nephrotic Syndrome", "Nuclear", "Patients", "Proteins", "Publishing", "RANTES", "RNA Splicing", "Recurrent disease", "Reed-Sternberg Cells", "Rhinovirus", "Rodent Model", "Signal Pathway", "Signal Transduction", "Source", "TNF gene", "TNFRSF1A gene", "Therapeutic", "Tissue Inhibitor of Metalloproteinase-1", "Tumor Necrosis Factor-Beta", "Xenograft procedure", "atopy", "cytokine", "cytokine release syndrome", "experimental study", "immunodeficiency", "improved", "kidney biopsy", "mouse model", "neoplastic cell", "podocyte", "prevent", "promoter", "receptor", "treatment response", "tumor" ], "approved": true } }, { "type": "Grant", "id": "12110", "attributes": { "award_id": "1R21AI175980-01", "title": "Improving the Immune Response to Nanoparticle-Based SARS-CoV-2 Vaccines", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6908, "first_name": "JENNIFER L.", "last_name": "Gordon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2025-08-31", "award_amount": 235500, "principal_investigator": { "id": 27974, "first_name": "SZU-WEN", "last_name": "WANG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 971, "ror": "", "name": "UNIVERSITY OF CALIFORNIA-IRVINE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Vaccines have been very effective at protecting against infectious diseases that pose serious threats to human health. However, prophylactic vaccines can also be limited, particularly if antigenic drift occurs to create variants of the pathogen; this can result in vaccines losing potency over time, needing boosters to confer protection, and lower neutralization efficacy on emerging viral variants – consequences which are observed in the current COVID-19 pandemic. Recent studies have shown that the release kinetics of vaccines can be important in establishing lasting and efficacious immunity. In particular, extending the exposure to antigens can result in higher antibody titers and increased diversity of neutralizing antibodies that target a more diverse set of epitopes, relative to immune responses from conventional bolus vaccination. Furthermore, vaccines made from protein-based nanoparticles can elicit increased antibody production, broader antigen cross-reactivity, and a more balanced Th1/Th2 response. This study tests the hypothesis that the synergy in combining the effects of nanoparticle vaccines for effective antigen presentation, together with a slower release to give a longer exposure to the vaccine, will elicit increased durability of the immune response and a broader cross-reactivity for emerging viral variants. To test this hypothesis, we propose to encapsulate protein nanoparticle vaccines with a biodegradable PLGA-PEG-PLGA (PPP)-based polymer to modulate the kinetics of its release from an in vivo vaccine depot. This extended-release vaccine strategy will then be applied towards SARS-CoV-2. We will evaluate the durability of the proposed vaccine strategy’s potency and the breadth of cross-reactive immune responses toward the variants of SARS-CoV-2 and other types of coronaviruses. Our specific aims are to: (1) create controlled-release nanoparticle depot vaccines against SARS-CoV-2, and (2) determine the efficacy and immunological responses to these vaccine nanoparticles that are encapsulated by the polymeric depot. Because the design of these vaccines is modular and different antigens can be exchanged in a relatively straightforward approach, the successful implementation of this proposed strategy for coronavirus antigens could have broader applicability towards the development of vaccines for other infectious pathogens.", "keywords": [ "2019-nCoV", "Adjuvant", "Antibodies", "Antibody Formation", "Antibody Response", "Antibody titer measurement", "Antigen Presentation", "Antigens", "Biological Assay", "Bolus Infusion", "COVID-19 pandemic", "COVID-19 vaccine", "Cells", "Communicable Diseases", "Coronavirus", "Encapsulated", "Epitopes", "Exposure to", "Formulation", "Health", "Histologic", "Human", "Hydrogels", "Immune", "Immune response", "Immunity", "Immunization", "In Vitro", "Individual", "Influenza", "Injections", "Kinetics", "Libraries", "Malignant Neoplasms", "Measures", "Mediating", "Mus", "Nature", "Physiological", "Polymers", "Preventive vaccine", "Protein Array", "Protein Engineering", "Proteins", "SARS-CoV-2 variant", "Secondary Immunization", "Serum", "Site", "Surface", "System", "T cell response", "T-Lymphocyte", "Temperature", "Testing", "Time", "Transition Temperature", "Vaccination", "Vaccine Design", "Vaccines", "Variant", "Viral", "Virus", "Work", "biodegradable polymer", "controlled release", "cross reactivity", "cytokine", "design", "efficacy evaluation", "emerging pathogen", "improved", "in vivo", "in vivo imaging system", "nanolabel", "nanoparticle", "nanovaccine", "neutralizing antibody", "pandemic disease", "particle", "pathogen", "receptor", "receptor binding", "response", "synergism", "vaccine delivery", "vaccine development", "vaccine effectiveness", "vaccine formulation", "vaccine strategy" ], "approved": true } }, { "type": "Grant", "id": "15479", "attributes": { "award_id": "5R21AI169330-02", "title": "Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6243, "first_name": "BROOKE ALLISON", "last_name": "Bozick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-06", "end_date": "2025-08-31", "award_amount": 191250, "principal_investigator": { "id": 28242, "first_name": "Marian L", "last_name": "Kohut", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 192, "ror": "https://ror.org/04rswrd78", "name": "Iowa State University", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Vaccination is an effective public health measure, yet host factors including advanced age, sex, obesity, physical or mental health status may influence vaccine efficacy. Adjuvants improve immunogenicity to vaccination but often result in greater side effects. As an alternative to the inclusion of adjuvants in the vaccine formulation, evidence suggests physical exercise performed at the time of immunization may serve as an effective non-pharmacological approach with the potential for greater impact in individuals with suboptimal immune response and reduced reactogenicity. The effect of host factors on immune response to SARS-CoV-2 and long-term protection remains to be established, and positive findings for an adjuvant-like effect of physical exercise would have an immediate translational impact. However, major barriers to the implementation of exercise are inconsistent findings and a gap in the knowledge of the mechanisms that underlie such effects. Our recent publication shows that we have identified an exercise protocol that consistently increases antibody response to vaccines that is reproducible across several different vaccines. This finding holds the potential to transform vaccine efficacy and address questions on the breadth and durability of immune response and underlying mechanisms. The goals of this application are to determine the extent to which physical exercise exhibits an adjuvant-like effect across long-term antibody and T cell-mediated immune responses to COVID-19 mRNA-based vaccines and establish the degree of immune enhancement in individuals who may have suboptimal vaccine response due to high psychological stress. An additional goal is to identify potential operative mechanisms, and compelling preliminary data show promise for metabolism-related mechanisms, a new direction in this field of study. Aim 1 will identify the extent to which a single exercise session applied at the time of initial immunization shapes the magnitude, breadth, and durability of immune response to SARS-CoV-2 mRNA vaccine. Outcome measures are serum anti-spike receptor-binding domain (RBD) IgG titer, neutralizing antibody, antigen-specific CD4+ and CD8+ T cell response measured up to one-year post-immunization. Aim 2 will determine the influence of psychological stress on antibody and antigen-specific CD4+ and CD8+ T cell immune response to SARS-CoV-2 immunization and the extent to which exercise may override any potential effect of stress. Aim 3 will apply transcriptomic (RNA-Seq) and metabolomic (Raman) measures to identify pathways by which exercise influences immune response to vaccination. The long-term goals of this research direction are to refine and develop behavioral interventions that optimize immunity and more broadly apply the findings learned with respect to critical pathways of immunogenicity to optimize vaccine development for currently underserved populations.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12330", "attributes": { "award_id": "1R21AI169330-01A1", "title": "Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6243, "first_name": "BROOKE ALLISON", "last_name": "Bozick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-06", "end_date": "2025-08-31", "award_amount": 224877, "principal_investigator": { "id": 28242, "first_name": "Marian L", "last_name": "Kohut", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 192, "ror": "https://ror.org/04rswrd78", "name": "Iowa State University", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Vaccination is an effective public health measure, yet host factors including advanced age, sex, obesity, physical or mental health status may influence vaccine efficacy. Adjuvants improve immunogenicity to vaccination but often result in greater side effects. As an alternative to the inclusion of adjuvants in the vaccine formulation, evidence suggests physical exercise performed at the time of immunization may serve as an effective non-pharmacological approach with the potential for greater impact in individuals with suboptimal immune response and reduced reactogenicity. The effect of host factors on immune response to SARS-CoV-2 and long-term protection remains to be established, and positive findings for an adjuvant-like effect of physical exercise would have an immediate translational impact. However, major barriers to the implementation of exercise are inconsistent findings and a gap in the knowledge of the mechanisms that underlie such effects. Our recent publication shows that we have identified an exercise protocol that consistently increases antibody response to vaccines that is reproducible across several different vaccines. This finding holds the potential to transform vaccine efficacy and address questions on the breadth and durability of immune response and underlying mechanisms. The goals of this application are to determine the extent to which physical exercise exhibits an adjuvant-like effect across long-term antibody and T cell-mediated immune responses to COVID-19 mRNA-based vaccines and establish the degree of immune enhancement in individuals who may have suboptimal vaccine response due to high psychological stress. An additional goal is to identify potential operative mechanisms, and compelling preliminary data show promise for metabolism-related mechanisms, a new direction in this field of study. Aim 1 will identify the extent to which a single exercise session applied at the time of initial immunization shapes the magnitude, breadth, and durability of immune response to SARS-CoV-2 mRNA vaccine. Outcome measures are serum anti-spike receptor-binding domain (RBD) IgG titer, neutralizing antibody, antigen-specific CD4+ and CD8+ T cell response measured up to one-year post-immunization. Aim 2 will determine the influence of psychological stress on antibody and antigen-specific CD4+ and CD8+ T cell immune response to SARS-CoV-2 immunization and the extent to which exercise may override any potential effect of stress. Aim 3 will apply transcriptomic (RNA-Seq) and metabolomic (Raman) measures to identify pathways by which exercise influences immune response to vaccination. The long-term goals of this research direction are to refine and develop behavioral interventions that optimize immunity and more broadly apply the findings learned with respect to critical pathways of immunogenicity to optimize vaccine development for currently underserved populations.", "keywords": [ "2019-nCoV", "Acute", "Address", "Adjuvant", "Antibodies", "Antibody Response", "Antigens", "Behavior Therapy", "Body Weight", "Buffers", "CD8-Positive T-Lymphocytes", "COVID-19", "COVID-19 vaccination", "COVID-19 vaccine", "Cellular Metabolic Process", "Chronic", "Complex", "Critical Pathways", "Data", "Dendritic Cells", "Dose", "Elderly", "Exercise", "Exhibits", "Formulation", "Gene Expression", "Glucocorticoids", "Goals", "Health Status", "Helper-Inducer T-Lymphocyte", "Immune", "Immune response", "Immunity", "Immunization", "Immunoglobulin G", "Immunologic Memory", "Impairment", "Individual", "Integration Host Factors", "Knowledge", "Learning", "Literature", "Maps", "Measures", "Mental Health", "Messenger RNA", "Metabolic", "Metabolism", "Modeling", "Moderna COVID-19 vaccine", "Obesity", "Outcome Measure", "Pathway interactions", "Patient Self-Report", "Pfizer-BioNTech COVID-19 vaccine", "Physical Exercise", "Population", "Positioning Attribute", "Protocols documentation", "Psychological Stress", "Psychosocial Stress", "Public Health", "Publications", "RNA vaccine", "Raman Spectrum Analysis", "Reporting", "Reproducibility", "Research", "Serum", "Shapes", "Standardization", "Stress", "Surveys", "T cell response", "T memory cell", "T-Lymphocyte", "Time", "Underserved Population", "Vaccination", "Vaccines", "bench-to-bedside translation", "cell mediated immune response", "cytokine", "field study", "human old age (65+)", "immune activation", "immunogenicity", "implementation barriers", "improved", "insight", "metabolic profile", "metabolomics", "neutralizing antibody", "novel", "pathogen", "perceived stress", "physical conditioning", "receptor binding", "response", "sex", "side effect", "transcriptome sequencing", "transcriptomics", "translational applications", "translational impact", "vaccine development", "vaccine efficacy", "vaccine formulation", "vaccine immunogenicity", "vaccine response" ], "approved": true } }, { "type": "Grant", "id": "13894", "attributes": { "award_id": "3K01MH118939-04S1", "title": "Optimizing an IMB-guided intervention to support HIV self-testing and PrEP uptake among YMSM: A pilot factorial RCT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Mental Health (NIMH)" ], "program_reference_codes": [], "program_officials": [ { "id": 6810, "first_name": "Susannah", "last_name": "Allison", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-04-01", "end_date": "2024-01-31", "award_amount": 46671, "principal_investigator": { "id": 30295, "first_name": "Steven A", "last_name": "John", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 700, "ror": "https://ror.org/00qqv6244", "name": "Medical College of Wisconsin", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT This application requests an administrative supplement under NOT-MH-21-120, “Administrative Supplements for COVID-19 Impacted NIMH Research.” The requested supplement is to K01-MH118939, “Optimizing an IMB-guided intervention to support HIV self-testing and PrEP uptake among YMSM: A pilot factorial RCT.” The parent grant is funded until August 31, 2023. The PI has suffered significant setbacks in the proposed research caused by the COVID-19 pandemic and exhausted all other means to help the project’s success. The impact of these setbacks resulted in the grant falling 24 months behind the initial timeline of research activities; the pandemic hit 7 months into the funded project. To help mitigate these effects, the PI outsourced participant recruitment, hired mHealth technical support, and funded additional personnel support; these remediation activities exhausted all funds available via rebudgeting and using remaining start-up (internal) funding. Despite these setbacks, the project is on track to complete clinical trial launch and baseline enrollment by the end of the funded project period. This supplement requests an additional 5-months salary support for the PI to complete the final Aim of the project. The requested funds will help support the PI collecting outcome data and conducting endpoint data analysis. This funding is essential to fulfill the research objectives of the parent award given the substantial risks to completion of the randomized controlled trial due to delays and impact caused by the COVID-19 pandemic. Failure to complete the clinical trial would reduce scientific advancements of the study and limit the PI’s ability to successfully compete for R01 funding in this line of research. The PI is in the final year of the K01 without additional extramural funding to continue this research trajectory; the PI’s recently awarded R34 has only 15% salary support and is a different line of research focused on increasing expedited partner therapy and pre-exposure prophylaxis (PrEP) prescribing practices among providers in Oklahoma. As such, the requested supplement will be instrumental to help the PI finish the proposed research and support his final training component related to translating pilot trial findings into an R01 application. The final research Aim of his project is to assess the feasibility, acceptability, and preliminary impact of an mHealth intervention for young sexual minority men to increase HIV self-testing and PrEP uptake and adherence. This supplement does not propose to extend the funded project period; however, we anticipate a no cost extension at conclusion of the active funding period. The estimated unobligated balance of the grant will be spent before the end of the project period or carried over to a no cost extension; the remaining funds for carry over are budgeted for remaining research expenses and dissemination. During the no cost extension, the PI will conduct follow-up assessments with participants, analyze and disseminate data, and prepare an R01 application based on feasibility, acceptability, and preliminary impact findings.", "keywords": [ "AIDS prevention", "Adherence", "Administrative Supplement", "Affect", "Age", "Attitude", "Award", "Behavioral", "Black race", "Budgets", "COVID-19 impact", "COVID-19 pandemic", "Caring", "Clinic", "Clinical", "Clinical Trials", "Counseling", "Data", "Data Analyses", "Development", "Devices", "Economics", "Enrollment", "Equilibrium", "Ethics", "Extramural Activities", "Face", "Failure", "Focus Groups", "Friends", "Funding", "Goals", "Grant", "HIV", "HIV Infections", "HIV Seropositivity", "Human Resources", "Human immunodeficiency virus test", "Incidence", "Individual", "Infection", "Insurance", "Intervention", "Interview", "Latinx", "Lesbian Gay Bisexual Transgender", "Liquid substance", "Mentors", "Methods", "Modeling", "Motivation", "National Institute of Mental Health", "Oklahoma", "Oral", "Outcome", "Outsourcing", "Parents", "Participant", "Patient Recruitments", "Population", "Pre-Post Tests", "Prevention", "Provider", "Public Health", "Randomized", "Randomized Controlled Trials", "Reporting", "Request for Applications", "Research", "Research Activity", "Research Methodology", "Risk", "Risk Reduction", "Route", "Scientific Advances and Accomplishments", "Self Administration", "Self Efficacy", "Surveys", "Testing", "Training", "Translating", "Treatment Efficacy", "United States Food and Drug Administration", "United States National Institutes of Health", "Wages", "Work", "Youth", "barrier to testing", "career", "career development", "condoms", "coping", "cost", "efficacy trial", "ethnic disparity", "exhaust", "falls", "follow up assessment", "follow-up", "improved", "mHealth", "pandemic disease", "parent grant", "pill", "pilot trial", "pre-exposure prophylaxis", "racial disparity", "recruit", "remediation", "self testing", "sexual minority men", "skills", "social stigma", "success", "therapy development", "timeline", "transmission process", "uptake", "young men who have sex with men" ], "approved": true } } ], "meta": { "pagination": { "page": 1385, "pages": 1405, "count": 14046 } } }