Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1384&sort=principal_investigator
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=principal_investigator", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=principal_investigator", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1385&sort=principal_investigator", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1383&sort=principal_investigator" }, "data": [ { "type": "Grant", "id": "15388", "attributes": { "award_id": "1R01HL171199-01A1", "title": "Imaging the Pulmonary Circulation to Aid Personalized Management of Acute Respiratory Distress Syndrome", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22454, "first_name": "GUOFEI", "last_name": "Zhou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-29", "end_date": "2029-06-30", "award_amount": 827682, "principal_investigator": { "id": 31989, "first_name": "Maurizio Franco", "last_name": "Cereda", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Acute Respiratory distress syndrome (ARDS) is a life-threatening condition caused by widespread pulmonary inflammation leading to lung injury. ARDS has a mortality that can be higher than 40% and is the main cause of death from COVID-19. Although necessary to support life, mechanical ventilation worsens ARDS. While computed tomography (CT) is capable of identifying characteristic abnormal airspace mechanics, the pulmonary circulation is also altered in ARDS, with profound dysregulation of lung perfusion resulting in regional elevations of blood flow and volume. Such misdistribution may significantly impact the trajectory of lung injury. In animal studies, ventilated lungs suffered from stress-failure of the capillary barrier when perfused at higher blood flows and pressures, resulting in more edema. Regions of the lung with elevated perfusion may therefore be at risk of worse injury. The pulmonary circulation is significantly understudied in ARDS due to the paucity of accurate and non-invasive instruments to visualize perfusion in vivo. This proposal addresses the need to elucidate the fundamental contribution of the pulmonary circulation to ARDS trajectory. We intend to develop a comprehensive imaging approach to characterize lung perfusion and direct treatment. We will leverage our expertise with two imaging modalities: a) dynamic contrast enhanced (DCE) and dual energy CT (DECT), which map pulmonary blood flow and volume with high resolution; b) electrical impedance tomography (EIT), a bedside technique that allows rapid and frequent assessments of pulmonary perfusion without moving patients to a scanner. We will use these techniques in animal and human studies to test our hypothesis that protecting the capillary barrier and manipulating pulmonary perfusion to decrease capillary stress failure attenuates ARDS progression. In a ventilated swine model of ARDS, we will demonstrate that reducing the heterogeneity of pulmonary perfusion mitigates lung injury using two treatments that redistribute pulmonary blood flow and volume: selective vasodilation with inhaled nitric oxide (iNO) and prone ventilation. We will match regional changes in perfusion and inflation with the subsequent progression of lung injury. We will then show that protecting the pulmonary capillaries in vulnerable lung regions decreases injury using Imatinib, a drug that preserves endothelial integrity, in our swine model. Finally, after refining our translational imaging pipeline, we will perform proof-of-principle studies in human ARDS using DECT and EIT to assess individual patient responses to iNO and prone ventilation, aiming to integrate such information into clinical decision-making. This proposal will demonstrate that it is possible to non-invasively assess pulmonary perfusion in order to guide ARDS treatment. Shifting the focus from airspace mechanics to a more comprehensive management of both lung perfusion and ventilation, the proposed approach will constitute a groundbreaking advancement in the care of ARDS.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15390", "attributes": { "award_id": "1U19AI181930-01", "title": "RP1: Antigen design and testing of arenavirus and nairovirus", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2024-07-30", "end_date": "2027-06-30", "award_amount": 4640498, "principal_investigator": { "id": 31991, "first_name": "Robert W", "last_name": "Cross", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 851, "ror": "", "name": "UNIVERSITY OF TEXAS MED BR GALVESTON", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "– RP1 (Antigen Design and Testing Of Arenavirus And Nairovirus Vaccines) The viral order Bunyavirales contains several high priority human pathogens. Notably, Arenaviridae and Nairoviridae families contain viruses which cause severe hemorrhagic diseases in humans across the world with mortality rates up to 60% and some are associated with significant, long-term sequelae in survivors. Of these, rodent borne arenaviruses – Lassa (LASV), Lujo, Chapare, Guanarito, Junin and Machupo viruses and one tickborne Nairovirus-Crimean-Congo Hemorrhagic Fever Virus- are identified as NIAID Category A pathogens due to ease of dissemination or transmission person-to-person, production of significant morbidity and mortality, the potential for major public health impact, and due to the requirement for special action for public health preparedness. Threats to public health are further heightened by the lack of internationally approved vaccines to address threats of natural epidemics as well as the potential bio-weaponization of these viruses. To address this unmet need, PABVAX RP1 will leverage combined expertise in high-containment virology, immunology, and biological product development, to develop arenavirus and nairovirus research tools and vaccine approaches using prototype members of each viral group which can be adapted across each viral family using a “plug-and-play” approach. Much of the work developing vaccines for these viruses has relied on isolates derived over 40 years ago, recent advances in viral reverse for these viral families is making vaccine testing of emerging isolates more feasible by improving access. Vaccine development for most arenaviruses and nairoviruses has centered on the understanding of the critical role for viral glycoproteins (GP) and nucleoproteins (NP) to drive natural immunity. We have recently successfully engineered a recombinant, stabilized prefusion LASV GPe to act as an antigenic mimic of viral surface displayed GP and found this trimeric GPe alone, co- delivered with NP, or NP subunits alone, can protect guinea pigs against lethal challenge by LASV underscoring the value of these antigens as vaccine components. Subunit vaccines are prime candidates for alternative vaccination approaches like microneedle patches (MNP). MNP coupled antigens and adjuvants directly interact with the potently immunoresponsive cutaneous microenvironments using dissolvable MNPs to elicit robust and long-lasting protective immunity against the target pathogen. The importance of humoral immunity for affording potent protection or treatment against viral infections cannot be understated as evidenced by the recent success using monoclonal antibody therapies to treat Ebola virus disease or COVID-19, yet little is known for the potential for pre-exposure prophylactic (PREP) administration of antibody therapies and what kind of prophylactic windows are possible. In this proposal, we will develop protective protein-based subunit-MNP vaccines, PREP treatment strategies, and recombinant virus tools using prototyped arenaviruses and nairoviruses which will template development of countermeasures against other related Bunyaviridae members.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15391", "attributes": { "award_id": "1R01AI185127-01", "title": "Beyond discovery: bat behavior and virus shedding as drivers of spillover risk", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6054, "first_name": "Eun-Chung", "last_name": "Park", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-15", "end_date": "2028-05-31", "award_amount": 759802, "principal_investigator": { "id": 31992, "first_name": "Kristian Michael", "last_name": "Forbes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 749, "ror": "https://ror.org/05jbt9m15", "name": "University of Arkansas at Fayetteville", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has reinforced the significance of emerging infectious diseases for human health and security. Bats have been associated with high-profile viral emergence events, including SARS-CoV-2 (the causative agent of COVID-19), ebolaviruses, and a variety of zoonotic and almost invariably lethal lyssaviruses. While much recent research has investigated virus diversity in bats, it is largely unknown how infection processes in bats and their behavior shape virus exposure risk for other species. Exposure is the obligatory first step for pathogen spillover and one of the strongest points for intervention in the process leading to the emergence of new human diseases. Further, bat displacements are commonly used to mitigate human risks posed by bat- borne viruses in low-income settings. Yet, how displacements and other perturbations affect viral exposure and spillover risk is not known, largely because the necessary longitudinal monitoring is rarely undertaken and is frustrated by challenges of appropriate controls and monitoring rare viruses in difficult to capture animals. This project will focus on three important and unusually tractable host-virus systems: coronaviruses, rabies virus, and Bombali ebolavirus in their wild bat hosts in Taita Hills, Kenya and Orange Walk, Belize. We will use a combination of longitudinal monitoring, bat behavior studies, and field experiments to examine how virus shedding dynamics in bat populations and bat use of anthropogenic structures shape virus exposure risk for humans and domestic animals that can act as intermediate hosts. To explore generalizability across viruses and assess whether perturbation triggers the shedding of latent viruses, we will further use proteomic and metagenomic approaches to characterize stress and immunological responses to perturbations and measure viral diversity shifts at a community level. Our multidisciplinary approach will confront field-collected virus serological, shedding, and sequence data with competing epidemiological models to elucidate fundamental principles driving viral infection and shedding from bats (aim 1); employ anthropogenic roost selection and use surveys to identify local- and landscape-level areas where human encounters with bats and virus are greatest (aim 2); and conduct controlled experimental displacements of wild bats through roost evictions to quantify the responses of bat stress, immunity, and viral communities to this common occurrence (aim 3). Together, these studies will represent an unusually comprehensive and detailed investigation into the dynamics of viruses in wild bat populations and provide a critical advance towards evidence-based risk evaluation and prevention.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15394", "attributes": { "award_id": "1P30GM154632-01", "title": "Center for Targeted Therapeutics", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 31995, "first_name": "WUHONG", "last_name": "Pei", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-15", "end_date": "2029-05-31", "award_amount": 1117500, "principal_investigator": { "id": 31996, "first_name": "Hippokratis", "last_name": "Kiaris", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 930, "ror": "", "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", "address": "", "city": "", "state": "SC", "zip": "", "country": "United States", "approved": true }, "abstract": "The Center for Targeted Therapeutics (CTT) was established in 2014 at the University of South Carolina (USC), with the mission to develop the institutional research in the area of experimental therapeutics aimed at molecular targets implicated in different pathologies. The Center has been transformative for translational biomedical research at USC. In phases 1 and 2, CTT has supported the research and mentoring of 15 junior faculty from several different Colleges who served as Research Project Leaders (RPL). Subsequently the RPLs have won 13 R01s and several smaller grants; 11 of them have been promoted to Associate or full Professor. In addition, 23 pilot projects were funded, with the pilot project leaders (PPL) subsequently winning 4 R01s and several smaller grants. Subsequent to CTT funding, the RPLs and PPLs published more than 300 articles and won over $50M in external funding, filed multiple patents and brought their drug candidates into the clinical trial pipeline. The CTT supported the recruitment of 9 junior faculty members and engaged at least three SmartState Endowed Chairs related to Targeted Therapeutics. CTT supports the operation of three resource cores: Functional Genomics, Microscopy and Flow Cytometry, and Drug Discovery Synthesis, that provide state-of-the-art services to investigators at USC and the State of SC. At the onset of COVID19 pandemic, the Functional Genomics core rapidly developed the SARS-Cov2 testing pipeline that, in the form of a CLIA lab, served the USC community throughout the pandemic. CTT also sponsored a special Pilot Project program in COVID19 therapeutics. During Phase 3, CTT will transition to self-sufficiency and sustainability, leveraging the progress attained so far by pursuing the following activities: 1). Support high-impact research projects in Targeted Therapeutics, by funding pilot projects, identifying scientific priority areas, and promoting collaborations in the area of Targeted Therapeutics. The pilot project awards will prioritize junior faculty, collaborative studies and the workforce diversification by engaging investigators that belong to or serve underserved groups. 2). Maintain and grow sustainable research infrastructure by supporting three strategic resource Cores: the Functional Genomics Core, the Drug Design and Synthesis Core, and the Microscopy and Flow Cytometry Core. 3). Assure long-term development of the CTT by broadening collaborative networking in Targeted Therapeutics. For this purpose, CTT will conduct Center meetings, arrange scientific seminars and promote external collaborations. CTT will also organize individual training and workshops aimed at developing multi-investigator and SBIR/STTR grant applications. CTT will work in alignment with Institutional priorities at USC to assure the sustainability of CTT research cores’ operation and continuous engagement and expansion of the critical mass of Targeted Therapeutics investigators that has been established during Phases 1 and 2. The CTT will promote the mission of the NIH IDeA program and will enhance the State's stature in Targeted Therapeutics research, continuing to make an impact on the public health, scientific education and economic development of the State.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15398", "attributes": { "award_id": "1R01DA061309-01", "title": "Employment Insecurity and Substance Use in U.S. Adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 31855, "first_name": "ERIN MARGARET", "last_name": "Parker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-15", "end_date": "2028-04-30", "award_amount": 373485, "principal_investigator": { "id": 31997, "first_name": "Jungeun Olivia", "last_name": "Lee", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 152, "ror": "https://ror.org/03taz7m60", "name": "University of Southern California", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Employment insecurity (EI; unemployment or underemployment) may escalate substance use as a maladaptive coping mechanism for distress. The COVID-19 pandemic triggered a rapid surge in EI for millions of Americans, hitting racial and ethnic minority and low socioeconomic status workers harder. The long-term impacts of the recent surge in EI on substance use are unknown. Employment recovery has been observed, but the speed has varied across subgroups and regional areas and future economic volatility looms. Despite robust cross-sectional associations of EI with substance use, prior studies have produced mixed results regarding the prospective effect of EI on substance use, its causal nature, and its differential impacts across racial and ethnic minority and low- SES workers. Moreover, the science base is unclear regarding which person-level factors are critical to address in interventions and how context-level factors intersect with person-level factors to buffer or amplify the impact of EI on substance use. National drug use surveys typically follow an annual or longer survey schedule that is not temporally granular enough to address these critical questions, leaving public officials without critical information to establish sound policies and practices related to EI as a means to reduce substance use. The proposed secondary data analysis study will address this challenge by isolating transitions in employment status (including underemployment) to elucidate the time course of effects (i.e., timing, duration, and trajectory of EI) on substance use. The study also will examine a targeted set of systemic environmental and individual factors that moderate the effects of EI on substance use and the mechanisms through which it affects substance use. We will anchor the inquiry in a novel conceptual model that synthesizes behavioral economic models of substance use with an ecological perspective. The model hypothesizes that people are motivated to engage in rewarding activities, and when critical sources that can bring rewards, such as full-time employment, are taken away, a cascading risk process is triggered, involving loss of financial and nonfinancial rewards, distress, mental health, and increased substance use. Environmental stressors and resources in the neighborhood may amplify or mitigate these forces. We will leverage the Understanding America Study (UAS), a nationally representative panel of 9,000-plus individuals. UAS involves high-frequency (biweekly from March 2020 to March 2021 and monthly thereafter until June 2022; 39 waves; 237,849 total observations) assessment of EI, substance use, financial and nonfinancial rewards, distress, and mental health. We will augment these intensive longitudinal data with neighborhood context data. The recent rapid surge in EI, its unknown long-term impacts on substance use, economic uncertainty, decades-long but unresolved debates regarding the causal nature of the EI– substance use link, and unknown interplay between person- and context-level factors that shapes the association of EI with substance use at the national level underscore the urgency and timeliness of this proposed study.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15399", "attributes": { "award_id": "1I01BX006408-01", "title": "Mechanism of the adrenal stress response protection against therapy-induced lethal immune activation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2024-07-01", "end_date": "2028-06-30", "award_amount": null, "principal_investigator": { "id": 31998, "first_name": "XIANG-AN", "last_name": "LI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2032, "ror": "", "name": "VA MEDICAL CENTER - LEXINGTON, KY", "address": "", "city": "", "state": "KY", "zip": "", "country": "United States", "approved": true }, "abstract": "Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for hematologic malignancies and other diseases, in which the donor's stem cells are used to replace the recipient's damaged or destroyed cells. The Veterans Health Administration has been offering allo-HCT services since 1982, which have saved thousands of veterans' lives. However, this life-saving therapy comes at a cost - lethal immune activation caused by cytokine release syndrome (CRS). Currently, glucocorticoids (GC) and IL-6 antagonists are used for CRS treatment, but some patients do not respond well to treatment. A limitation is that CRS may cause irreversible organ injury before treatment is initiated, as the indicator of treatment is CRS itself. Therefore, there is an urgent need to identify patients at high risk of CRS and provide preventive therapy. We recently reported that the adrenal stress response, defined by a 6-fold increase in induced GC (iGC) production, is an essential host response against therapy- induced lethal immune activation. We identified scavenger receptor BI (SR-BI), an HDL receptor, as a key regulator for iGC production. Using SR-BI null mice as an adrenal stress response deficiency model, we demonstrated that the adrenal stress response protects against therapy-induced death by controlling CRS. Conversely, relative adrenal insufficiency (RAI) - the absence of adrenal stress response - is a risk factor for CRS. Our study provides proof-of-concept that diagnosing RAI may help identify patients at risk of CRS, and selective GC therapy for patients with RAI prior to the onset of CRS may reduce mortality from therapy-induced lethal immune activation. The goal of this application is to delineate the mechanisms of the adrenal stress response protection against CRS in allo-HCT-induced lethal immune activation and to translate the mechanistic findings into a precision medicine approach to prevent CRS in allo-HCT- induced lethal immune activation.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15400", "attributes": { "award_id": "1R56NS138437-01", "title": "Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-catenin", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 6896, "first_name": "WILLIAM PATRICK", "last_name": "Daley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-15", "end_date": "2025-06-30", "award_amount": 561155, "principal_investigator": { "id": 31999, "first_name": "Sarah Elizabeth", "last_name": "Lutz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 163, "ror": "https://ror.org/02mpq6x41", "name": "University of Illinois at Chicago", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 increases the risk of vascular contributions to cognitive impairment and dementia (VCID). VCID is one of the most prevalent forms of dementia, so the potential public health impact of the COVID-19 pandemic on future VCID is substantial. However, the mechanisms by which COVID-19 modifies VCID are unknown. Identifying mechanisms that regulate how prior COVID-19 influences the brain endothelial cell response to vascular stress is important. Here, we provide preliminary evidence that COVID-19 decreases resistance to VCID by weakening the blood-brain barrier (BBB). This is accompanied by cerebrovascular inflammation. This grant will test the novel mechanism that SARS-CoV-2 infection accelerates VCID by suppressing cerebrovascular Wnt/β-catenin signaling. In Aim 1, we determine how prior SARS-CoV-2 infection influences BBB permeability and cognition upon subsequent vascular insult, by genetic and epigenetic modification. In Aim 2 we use endothelial-targeted genetic interventions to assess the contribution of Wnt/β- cat targets to resistance to post-infectious VCID. In Aim 3, we ask whether established post-infectious VCID can be reversed by increasing cerebrovascular Wnt/β-catenin. These studies could lead to novel approaches to identify individuals at high risk for VCID and novel potential therapeutic strategies to mitigate the impact of prior infection on the development of dementia.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15512", "attributes": { "award_id": "1R01NS135072-01A1", "title": "Targeting cerebrovascular Wnt/beta-catenin signaling to reverse brain endothelial damage induced by SARS-CoV-2 infection", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 6896, "first_name": "WILLIAM PATRICK", "last_name": "Daley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-12-01", "end_date": "2029-11-30", "award_amount": 801329, "principal_investigator": { "id": 31999, "first_name": "Sarah Elizabeth", "last_name": "Lutz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2548, "ror": "", "name": "UNIVERSITY OF ILLINOIS AT CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "Many COVID-19 survivors experience long-lasting neurological post-acute sequelae of COVID-19 (NeuroPASC) including cognitive, cerebrovascular, and neurological disorders. The causes of NeuroPASC are not understood. However, evidence suggests that blood-brain barrier damage may contribute to NeuroPASC. Identifying mechanisms that regulate the brain endothelial cell response in NeuroPASC is therefore important. Wnt/β-catenin signaling plays a critical role in maintaining integrity of the blood-brain barrier. This grant will test the novel mechanism that Wnt/β-catenin dysregulation in brain endothelial cells contributes to NeuroPASC by increasing blood-brain barrier permeability and neuroinflammation. We will determine the effect of age on brain endothelial cell signaling and blood-brain barrier permeability for the resolution of NeuroPASC. We will define the mechanism by which Wnt/β-catenin activation reverses blood-brain barrier leakage and memory impairment in NeuroPASC. We will determine the extent through which transcellular blood-brain barrier permeability contributes to NeuroPASC. These studies could identify future therapeutic strategies leveraging Wnt/β-catenin signaling to improve chronic post-infectious neurological diseases.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15763", "attributes": { "award_id": "1RF1NS138437-01A1", "title": "Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-catenin", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 32579, "first_name": "WILLIAM PATRICK", "last_name": "DALEY", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-08-11", "end_date": "2029-07-31", "award_amount": 2549080, "principal_investigator": { "id": 31999, "first_name": "Sarah Elizabeth", "last_name": "Lutz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2631, "ror": "", "name": "UNIVERSITY OF ILLINOIS AT CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 increases the risk of vascular contributions to cognitive impairment and dementia (VCID). VCID is one of the most prevalent forms of dementia, so the potential public health impact of the COVID-19 pandemic on future VCID is substantial. However, the mechanisms by which COVID-19 modifies VCID are unknown. Identifying mechanisms that regulate how prior COVID-19 influences the brain endothelial cell response to vascular stress is important. Here, we provide preliminary evidence that COVID-19 decreases resistance to VCID by weakening the blood-brain barrier (BBB). This is accompanied by cerebrovascular inflammation. This grant will test the novel mechanism that SARS-CoV-2 infection accelerates VCID by suppressing cerebrovascular Wnt/β-catenin signaling. In Aim 1, we determine how prior SARS-CoV-2 infection influences BBB permeability and cognition upon subsequent vascular insult, by genetic and epigenetic modification. In Aim 2 we use endothelial-targeted genetic interventions to assess the contribution of Wnt/β- cat targets to resistance to post-infectious VCID. In Aim 3, we ask whether established post-infectious VCID can be reversed by increasing cerebrovascular Wnt/β-catenin. These studies could lead to novel approaches to identify individuals at high risk for VCID and novel potential therapeutic strategies to mitigate the impact of prior infection on the development of dementia.", "keywords": [ "2019-nCoV", "ATAC-seq", "Acceleration", "Acute", "Blood - brain barrier anatomy", "Blood Vessels", "Blood brain barrier dysfunction", "COVID-19", "COVID-19 pandemic effects", "Cells", "Cerebrovascular system", "Clinic", "Cognition", "Critical Pathways", "Data", "Dementia", "Development", "Endothelial Cells", "Endothelium", "Engineering", "Epigenetic Process", "Extravasation", "Functional disorder", "Future", "Genes", "Genetic", "Goals", "Grant", "High Fat Diet", "Human", "Hypertension", "Impaired cognition", "Individual", "Infection", "Inflammation", "Inflammatory", "Knowledge", "Ligands", "Modification", "Mus", "Pathogenicity", "Pathway interactions", "Pattern", "Pericytes", "Permeability", "Phenotype", "Prevention", "Public Health", "Recording of previous events", "Recovery", "Research", "Resistance", "Respiratory Tract Infections", "Risk", "Risk Factors", "Role", "SARS-CoV-2 infection", "Signal Transduction", "Testing", "Therapeutic", "Translating", "Vascular Dementia", "Viral", "beta catenin", "blood-brain barrier permeabilization", "brain endothelial cell", "cerebrovascular", "gene therapy", "high risk", "in vivo", "inhibitor", "macromolecule", "mouse model", "neuroinflammation", "neurotoxic", "novel", "novel strategies", "post SARS-CoV-2 infection", "post-pandemic", "prevent", "programs", "promote resilience", "respiratory", "response", "small molecule", "therapeutic target", "transcriptome sequencing", "vascular cognitive impairment and dementia", "vascular stress" ], "approved": true } }, { "type": "Grant", "id": "15402", "attributes": { "award_id": "1R36AG087312-01", "title": "An Analysis Of The Multi-Level Factors That Impact Provision Of Emergency Medical Services To Hispanic Older Adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 24509, "first_name": "Susan", "last_name": "Zieman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-15", "end_date": "2026-06-30", "award_amount": 41469, "principal_investigator": { "id": 32003, "first_name": "Esmeralda", "last_name": "Melgoza", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 818, "ror": "", "name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Hispanics are one of the fastest growing populations of older adults in the United States (U.S.). From 2019 to 2060, the population of Hispanic older adults aged 65 years and over in the U.S. is projected to increase from 9% to 21%. Existing literature suggests that Hispanic older adults experience health disparities across multiple sectors of the U.S. healthcare system, including emergency medicine. Emergency medical services (EMS) provided in the prehospital setting, however, are a largely understudied sector in the U.S. healthcare system, especially in the context of Hispanic older adults. EMS serve as an important entry point into the U.S. healthcare system for Hispanic older adults who often have challenges accessing preventive and diagnostic care. The objectives of the proposed dissertation are three-fold: 1) assess the individual, neighborhood, and structural-level factors that impact the provision of EMS care by emergency medical technicians and paramedics to Hispanic older adults; 2) examine the individual and neighborhood-level factors that impact the provision of EMS to Hispanic older adults experiencing a high-acuity, time sensitive, cardiac-related 9-1-1 emergency; and 3) determine the individual and neighborhood-level factors that impact the provision of EMS for Hispanic older adults experiencing a psychiatric-related 9-1-1 emergency, a type of call often triaged as low acuity. The National Institute of Aging’s Health Disparities Framework provides the theoretical foundation for the three studies that comprise this dissertation. The first study in this dissertation is a systematic literature review, an increasingly important approach to synthesize existing literature and provide justification for future research. The second and third studies use data from three sources, including the San Francisco Department of Emergency Management, San Francisco Department of Public Health, and the 2020 and 2021 American Community Survey. The PRISMA 2020 guidelines and Covidence software inform the completion of the systematic literature review, which addresses the first objective. Logistic regression and multilevel modeling are used to: 1) examine the association between individual and neighborhood-level factors and high- acuity, cardiac-related 9-1-1 emergency calls, which address the second objective; and 2) assess the association between individual and neighborhood-level factors with low-acuity, psychiatric-related 9-1-1 emergency calls, which address the third objective. Neighborhood in the second and third objectives refers to ZIP code as the level of geospatial analysis. Stata 17.0 and R are used to run the statistical analyses in the second and third studies. The proposed dissertation will offer insights on the provision of EMS to Hispanic older adults. The findings from this dissertation can inform ongoing efforts to make the EMS system more accessible, age-friendly, and equitable.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1384, "pages": 1405, "count": 14046 } } }