Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1384&sort=keywords
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=keywords", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=keywords", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1385&sort=keywords", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1383&sort=keywords" }, "data": [ { "type": "Grant", "id": "9847", "attributes": { "award_id": "5G13LM013554-02", "title": "Sickness and Power: The Great North American Epizootic Flu of 1872", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Library of Medicine (NLM)" ], "program_reference_codes": [], "program_officials": [ { "id": 10715, "first_name": "YANLI", "last_name": "WANG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-07-01", "end_date": "2024-06-30", "award_amount": 47922, "principal_investigator": { "id": 24187, "first_name": "Thomas G", "last_name": "Andrews", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1583, "ror": "", "name": "UNIVERSITY OF COLORADO", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1583, "ror": "", "name": "UNIVERSITY OF COLORADO", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "The recent outbreak of COVID-19 and the upswing in seasonal influenza this winter offer pressing reminders of the enduring, even intensifying dangers that emergent zoonotic diseases— disorders caused by pathogens that jump across species divides—pose to human health. Historians of medicine and other scholars have long recognized the power of such diseases to shape human history. Yet few works in epidemiological history have attended to the complicated relationships that continue to link pathogens, humans, other-than-human animals, and the natural and built ecosystems that connect the lives—and, often, the deaths—of these disparate organisms. This proposal seeks to remedy this gap by supporting the completion of a Geographic Information System (GIS) and scholarly book examining the Great Epizootic Influenza of 1872. This little-known disease event began in Toronto’s market-farming hinterland, where the continuous exchange of pathogens between humans, horses, other farm animals, and wild waterfowl set the stage for the evolution of a new and unprecedentedly virulent form of influenza A virus. Within weeks, swarms of the new virus had engulfed metropolitan Toronto. It took just another month for the disease to spread throughout southeastern Canada and the northeastern U.S. By summer 1873, flu had sickened well over 90% of the horses, mules, and asses in the U.S., Canada, Cuba, Mexico, the Indigenous Nations of the West, and parts of Central America. As it achieved continental proportions, the Great Epizootic prompted economic paralysis, debate about the malady’s nature and treatment, and more than a little soul-searching over human use and misuse of “the noble horse.” Although the disease seemed to dissipate in fall 1873, recent scientific studies strongly suggest that the new flu type responsible for the Great Epizootic lived on and continued to adapt. Descendants of this viral type went on to develop the ability to infect human populations, too, most notably in the Great Pandemic of 1918-’20, a worldwide influenza outbreak that killed at least 50 million people. This proposal supports research in historical documents, the integration of evidence from these primary sources into a Geographic Information System (GIS), and the completion of a scholarly book that casts the Great Epizootic Flu as an unheralded but momentous event in disease history. Employing methodologies and findings from virology, evolutionary ecology, animal behavior, environmental history, and other fields, and adopting a transnational perspective that tracks this outbreak across regional, national, and tribal boundaries, this book offers fresh insights into the past, present, and future of influenza and the many other infectious diseases that don novel configurations—and hence new powers to endanger human and animal health alike—by passing from species to species.", "keywords": [ "AIDS/HIV problem", "Adopted", "American", "Animal Behavior", "Animals", "Antisepsis", "Archives", "Area", "Avian Influenza", "Behavior", "Books", "Boston", "Buffaloes", "Businesses", "COVID-19", "COVID-19 outbreak", "Canada", "Case Study", "Cause of Death", "Central America", "Cessation of life", "Communicable Diseases", "Complex", "Cuba", "Disease", "Disease Outbreaks", "Domestic Fowls", "Donkeys", "Ebola", "Ecology", "Economics", "Ecosystem", "Environment", "Epidemiology", "Epistemology", "Equine mule", "Equus caballus", "Event", "Evolution", "Fire - disasters", "Flu virus", "Frequencies", "Future", "Geographic Information Systems", "Germ", "Goals", "Gossypium", "Government", "Growth", "HIV", "Health", "History of Medicine", "Human", "Indigenous", "Influenza", "Influenza A virus", "Information Technology", "Instruction", "Life", "Light", "Link", "Literature", "Livestock", "Medical Geography", "Medicine", "Methodology", "Mexico", "Modernization", "Movement", "Nature", "North America", "Northern America", "Organism", "Panic", "Paralysed", "Pathogenicity", "Pattern", "Periodicals", "Persons", "Physicians", "Play", "Pneumonia", "Population", "Population Density", "Publications", "Publishing", "Recording of previous events", "Records", "Reporting", "Research", "Research Support", "Role", "Rural", "Scientist", "Shapes", "Social Behavior", "Societies", "Source", "Speed", "Steam", "System", "Testing", "Therapeutic", "Time", "Training", "Transportation", "Vaccination", "Viral", "Virulence", "Virulent", "Virus", "Visualization", "War", "Work", "ZIKA", "Zoonoses", "antimicrobial", "diaries", "epidemiology study", "epizootic", "falls", "flu", "government documents", "influenza outbreak", "insight", "metropolitan", "microorganism", "newspaper article", "novel", "pandemic disease", "pandemic influenza", "pathogen", "seasonal influenza", "social", "theories", "tool", "transmission process", "virology" ], "approved": true } }, { "type": "Grant", "id": "5348", "attributes": { "award_id": "3U54MD007598-14S1", "title": "Accelerating Excellence in Translational Science (AXIS)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 18770, "first_name": "Rina", "last_name": "Das", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2009-09-28", "end_date": "2024-02-29", "award_amount": 358750, "principal_investigator": { "id": 18771, "first_name": "JAYDUTT V", "last_name": "VADGAMA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 907, "ror": "", "name": "CHARLES R. DREW UNIVERSITY OF MED & SCI", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract: Proposed Program Overview. The Charles R. Drew University of Medicine and Science proposes to continue the enhancement and success of the Accelerating Excellence in Translational Science (AXIS) Center. AXIS has shown to be the integrated hub for research conducted at CDU and continues to provide experienced leadership, and a myriad of clinical, translational, and community partnered activities. In the next five years, research will continue to grow and expand its enterprise alongside the Universities vision and mission to be a leader in eliminating health disparities by translating scientific discoveries into education, training, clinical care, treatment, and community service in three areas of focus which disproportionally affect Service Planning Area 6: Cancer, Cardiometabolic Disease (CMD), and HIV/AIDS. In addition, we look to build upon the application of Precision Medicine to understand and eliminate health disparities, while utilizing many of CDU’s outstanding resources in: Advanced Technologies such as Next Generation Sequencing for identifying Genomic Data; Drug Discovery; Integrated Clinical Tissues, Biorepository and Bio banking Facility; Clinical Studies/Trials Resources; Medical Bioinformatics; and Methods for Statistical and Epidemiological Studies. This approach will pave the pathway for CDU’s in becoming a competitive institution with sophisticated resources and services to better serve our communities. To accomplish this, we propose to continue with the three programmatic goals that align with the mission, vision, and strategic plan for the universities research enterprise: Goal 1: To enhance the infrastructure capacity in translational research using Precision Medicine model in the areas of Cancer, Cardiometabolic, and HIV/AIDS. Provide support for the emerging research pillars in Mental Health and Health Services Goal 2: To continue the integration of basic, clinical, behavioral and community-partnered research by fostering collaboration among disciplines, departments and schools at CDU, and sustainable collaboration with community leaders and investigators across other research institutions. Goal 3: To facilitate and elevate professional development and best practices in mentored clinical and translational research training on minority health and health disparities.", "keywords": [ "AIDS/HIV problem", "Affect", "African American", "Area", "Behavioral", "Bioinformatics", "Cardiometabolic Disease", "Cardiovascular Diseases", "Center for Translational Science Activities", "Chronic", "Clinical", "Clinical Research", "Collaborations", "Communicable Diseases", "Communities", "Community Services", "County", "Development", "Diabetes Mellitus", "Diagnosis", "Discipline", "Environmental Risk Factor", "Epigenetic Process", "Fostering", "Goals", "Health", "Health Services", "Hispanics", "Hypertension", "Incidence", "Infrastructure", "Institution", "Intervention", "Latino", "Leadership", "Location", "Los Angeles", "Malignant Neoplasms", "Medical", "Medicine", "Mental Health", "Mental Health Services", "Mentors", "Mission", "Modeling", "Molecular Genetics", "Morbidity - disease rate", "Obesity", "Outcome", "Pathway interactions", "Reduce health disparities", "Research", "Research Personnel", "Research Training", "Resources", "Schools", "Science", "Services", "Statistical Methods", "Statistical Study", "Strategic Planning", "Technology", "Tissues", "Training and Education", "Translating", "Translational Research", "Universities", "Vision", "biobank", "cardiometabolism", "care systems", "clinical care", "demographics", "drug discovery", "epidemiology study", "experience", "genomic data", "health care availability", "health disparity", "minority health", "mortality", "next generation sequencing", "precision medicine", "programs", "public health relevance", "racial and ethnic", "socioeconomics", "success", "treatment services" ], "approved": true } }, { "type": "Grant", "id": "6156", "attributes": { "award_id": "3U54MD007598-13S1", "title": "Accelerating Excellence in Translational Science (AXIS)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 20905, "first_name": "Rina", "last_name": "Das", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2009-09-28", "end_date": "2024-02-29", "award_amount": 116202, "principal_investigator": { "id": 20906, "first_name": "JAYDUTT V", "last_name": "VADGAMA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 907, "ror": "", "name": "CHARLES R. DREW UNIVERSITY OF MED & SCI", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract: Proposed Program Overview. The Charles R. Drew University of Medicine and Science proposes to continue the enhancement and success of the Accelerating Excellence in Translational Science (AXIS) Center. AXIS has shown to be the integrated hub for research conducted at CDU and continues to provide experienced leadership, and a myriad of clinical, translational, and community partnered activities. In the next five years, research will continue to grow and expand its enterprise alongside the Universities vision and mission to be a leader in eliminating health disparities by translating scientific discoveries into education, training, clinical care, treatment, and community service in three areas of focus which disproportionally affect Service Planning Area 6: Cancer, Cardiometabolic Disease (CMD), and HIV/AIDS. In addition, we look to build upon the application of Precision Medicine to understand and eliminate health disparities, while utilizing many of CDU’s outstanding resources in: Advanced Technologies such as Next Generation Sequencing for identifying Genomic Data; Drug Discovery; Integrated Clinical Tissues, Biorepository and Bio banking Facility; Clinical Studies/Trials Resources; Medical Bioinformatics; and Methods for Statistical and Epidemiological Studies. This approach will pave the pathway for CDU’s in becoming a competitive institution with sophisticated resources and services to better serve our communities. To accomplish this, we propose to continue with the three programmatic goals that align with the mission, vision, and strategic plan for the universities research enterprise: Goal 1: To enhance the infrastructure capacity in translational research using Precision Medicine model in the areas of Cancer, Cardiometabolic, and HIV/AIDS. Provide support for the emerging research pillars in Mental Health and Health Services Goal 2: To continue the integration of basic, clinical, behavioral and community-partnered research by fostering collaboration among disciplines, departments and schools at CDU, and sustainable collaboration with community leaders and investigators across other research institutions. Goal 3: To facilitate and elevate professional development and best practices in mentored clinical and translational research training on minority health and health disparities.", "keywords": [ "AIDS/HIV problem", "Affect", "African American", "Area", "Behavioral", "Bioinformatics", "Cardiometabolic Disease", "Cardiovascular Diseases", "Center for Translational Science Activities", "Chronic", "Clinical", "Clinical Research", "Collaborations", "Communicable Diseases", "Communities", "Community Services", "County", "Development", "Diabetes Mellitus", "Diagnosis", "Discipline", "Environmental Risk Factor", "Epigenetic Process", "Fostering", "Goals", "Health", "Health Services", "Hispanics", "Hypertension", "Incidence", "Infrastructure", "Institution", "Intervention", "Latino", "Leadership", "Location", "Los Angeles", "Malignant Neoplasms", "Medical", "Medicine", "Mental Health", "Mental Health Services", "Mentors", "Mission", "Modeling", "Molecular Genetics", "Morbidity - disease rate", "Obesity", "Outcome", "Pathway interactions", "Research", "Research Personnel", "Research Training", "Resources", "Schools", "Science", "Services", "Statistical Methods", "Statistical Study", "Strategic Planning", "Technology", "Tissues", "Training and Education", "Translating", "Translational Research", "Universities", "Vision", "biobank", "cardiometabolism", "care systems", "clinical care", "demographics", "drug discovery", "epidemiology study", "experience", "genomic data", "health care availability", "health disparity", "minority health", "mortality", "next generation sequencing", "precision medicine", "programs", "public health relevance", "racial and ethnic", "socioeconomics", "success", "treatment services" ], "approved": true } }, { "type": "Grant", "id": "6221", "attributes": { "award_id": "3D43TW010547-05S1", "title": "African Centre for Biostatistical Excellence", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 21078, "first_name": "GEETHA PARTHASARATHY", "last_name": "Bansal", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-06-19", "end_date": "2022-04-30", "award_amount": 75089, "principal_investigator": { "id": 21079, "first_name": "Rhoderick", "last_name": "Machekano", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1027, "ror": "", "name": "STELLENBOSCH UNIVERSITY TYGERBERG CAMPUS", "address": "", "city": "", "state": "", "zip": "", "country": "SOUTH AFRICA", "approved": true } ] }, "other_investigators": [ { "id": 21080, "first_name": "Taryn Natalie", "last_name": "Young", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1027, "ror": "", "name": "STELLENBOSCH UNIVERSITY TYGERBERG CAMPUS", "address": "", "city": "", "state": "", "zip": "", "country": "SOUTH AFRICA", "approved": true }, "abstract": "LMIC: South Africa Institution: Stellenbosch University, Cape Town Scientific Area: Biostatistics for HIV research design and methodology Africa Center for Biostatistical Excellence: Building Biostatistics Capacity for HIV/AIDS Research This application is in response to the FOA “Fogarty HIV Research Training Program for Low- and Middle-Income Country Institutions” under the D43 grant mechanism (FOA PAR-16-279) and requests 5 years of support to build biostatistics capacity for HIV research design and methodology and establish an Africa Center for Biostatistical Excellence (ACBE) at Stellenbosch University in South Africa. The creation of a sustainable, multidisciplinary health research enterprise in Sub-Saharan Africa (SSA) is of paramount importance for improving health, promoting development and advancing science in the region. SSA continues to experience a disproportionate burden of both HIV/AIDS and TB relative to the rest of the world that has led to increases prevention programs as well as research activities to try and stop the pandemic. The growth in HIV/AIDS and TB research activities has created a demand for well-trained methodologists who can contribute to the design, conduct, analysis and reporting of research studies and provide mentoring and training of the next generation of researchers. Locally trained methodologists, including epidemiologists, social scientists and (to a lesser extent) health economists are now available in many African countries. However, despite various efforts in SSA, there remains a critical shortage of biostatistics expertise. Biostatisticians are integral members of research teams required for their skills in writing competitive grants, executing statistical procedures, conducting advanced data analysis, publishing in high profile journals and teaching biostatistics at the postgraduate level. To meet the demand for biostatistical experts, we propose to setup an Africa Center for Biostatistical Excellence (ACBE) at Stellenbosch University with a mission to implementing high quality training programs in biostatistics to meet the HIV research needs and competitiveness of both Stellenbosch University (SU), and SSA region. The specific objectives of this training grant are to: (1) to build biostatistics capacity through a formal Master level academic program at Stellenbosch University; (2) to build biostatistical literacy among biomedical researchers through short courses in Sub-Saharan Africa; (3) to develop biostatistics teaching capacity through specialized seminars and staff development programs; (4) to setup the Africa Center for Biostatistical Excellence; A Center for Biostatistical Excellence is a direct response to one of Fogarty’s strategic plan of building sustainable research environments through centers of research excellence. These research “hubs” are a way to enrich and sustain the research capacity of an institution by linking it to other sites within a country and across a region. Our proposed ACBE will complement training efforts in other areas of HIV/AIDS and TB research across the SSA region.", "keywords": [ "AIDS/HIV problem", "Africa", "Africa South of the Sahara", "African", "Area", "Biometry", "Centers of Research Excellence", "Complement", "Country", "Data Analyses", "Development", "Educational process of instructing", "Environment", "Epidemiologist", "Grant", "Growth", "HIV", "Health", "Institution", "Journals", "Link", "Mentors", "Mission", "Prevention program", "Procedures", "Program Development", "Publishing", "Reporting", "Research", "Research Activity", "Research Design", "Research Methodology", "Research Personnel", "Research Training", "Rest", "Science", "Scientist", "Site", "South Africa", "Staff Development", "Strategic Planning", "Training", "Training Programs", "Universities", "Writing", "academic program", "design", "experience", "improved", "literacy", "low and middle-income countries", "member", "multidisciplinary", "next generation", "pandemic disease", "research study", "response", "skills", "social" ], "approved": true } }, { "type": "Grant", "id": "6101", "attributes": { "award_id": "3U54MD007582-36S1", "title": "FAMU Center for Health Disparities Research", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 20761, "first_name": "Crystal", "last_name": "Barksdale", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2024-02-29", "award_amount": 323255, "principal_investigator": { "id": 20762, "first_name": "KARAM F.A.", "last_name": "SOLIMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 896, "ror": "", "name": "FLORIDA AGRICULTURAL AND MECHANICAL UNIV", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall goal of this community partnership is to expose social determinants as well as behavioral, and ethical factors that may influence COVID-19 vaccination among racial, ethnic, and vulnerable community populations in Gadsden County, Florida. The County has among the country's highest shares of residents who are housed in nursing homes, prisons, or in other institutionalized group quarters (8.4%), and of households with no access to a vehicle (11.7%). Over the years, the College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health has developed strong collaborative relationships with community organizations in Gadsden County through various community-based participatory research projects. The study investigators have partnered with Gadsden County stakeholders and community-based organizations on several racial disparity issues such as infant mortality, cancer, diabetes, cardiovascular disease, and HIV/AIDS. As part of our community-based participatory approach, we will partner with the Gadsden Community Health Council to implement a quantitative survey to measure the perceptions of the community regarding the disparities in COVID-19 among racial/ethnic populations as well as intent to vaccinate against the virus. Additionally, qualitative interviews will be conducted with community members to better understand perceptions of vaccine hesitancy among vulnerable racial and ethnic populations. A behavioral intervention will be implemented utilizing CDC’s Community-Based Organizations COVID-19 Vaccine Toolkit and The Toolkit for Community and Faith-Based Organizations. Pre and Post intention to vaccinate will be based on the Theory of Planned Behavior.", "keywords": [ "AIDS/HIV problem", "African American", "Age", "Assisted Living Facilities", "Attitude", "Awareness", "Behavior", "Behavior Therapy", "Behavioral", "Belief", "Biological", "COVID-19", "COVID-19 outbreak", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Cardiovascular Diseases", "Censuses", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Communities", "Community Health", "Community based prevention", "Correctional Institutions", "Country", "County", "Data", "Depressed mood", "Diabetes Mellitus", "Discrimination", "Economically Deprived Population", "Education", "Ethics", "Ethnic group", "Exposure to", "Florida", "Goals", "Health", "Health behavior", "Hispanics", "Home", "Hospitals", "Household", "Human", "Individual", "Infant Mortality", "Institutes", "Institution", "Intention", "Intervention", "Interview", "Latino", "Malignant Neoplasms", "Measures", "Medical", "Medically Underserved Area", "Medicare/Medicaid", "Mental Health", "Minority Groups", "Modeling", "Not Hispanic or Latino", "Nursing Homes", "Obesity", "Outcome", "Participant", "Perception", "Persons", "Pharmacologic Substance", "Pharmacy facility", "Planning Theory", "Population", "Prisons", "Psychiatric Hospitals", "Public Health", "Quality of life", "Research", "Research Personnel", "Research Project Grants", "Resources", "Risk", "Science", "State Hospitals", "Surveys", "Target Populations", "Testing", "Time", "United States Health Resources and Services Administration", "Vaccinated", "Vaccines", "Virus", "Vulnerable Populations", "World Health Organization", "base", "college", "community based participatory research", "community organizations", "community partnership", "comorbidity", "disadvantaged population", "educationally disadvantaged", "experience", "health care availability", "health disparity", "health training", "high risk", "infection rate", "instrument", "interest", "member", "programs", "public health emergency", "racial and ethnic", "racial disparity", "racial population", "racism", "severe COVID-19", "social", "social determinants", "social group", "social structure", "vaccine acceptance", "vaccine distribution", "vaccine hesitancy" ], "approved": true } }, { "type": "Grant", "id": "8926", "attributes": { "award_id": "1C06OD032071-01", "title": "Novel Macaque Breeding Runs at the New Iberia Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 23882, "first_name": "CHARLES ASHLEY", "last_name": "Barnes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-09-20", "end_date": "2024-09-30", "award_amount": 3506529, "principal_investigator": { "id": 24751, "first_name": "Francois J", "last_name": "Villinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette is aiming to expand its macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation. This type of building has been specifically designed and extensively tested for macaque housing/breeding at another facility in Texas, attesting to the adequacy, ease of maintenance and duration of construction. Each building unit will comprise 20 indoor/outdoor runs able to easily accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the testing of COVID-19 vaccines and antibody treatments. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the addition of 2200 nonhuman primates over the past 5 years. This has been accommodate by gradually repurposing chimpanzee housing into breeding and research space, but this conversion has reached its limits and NIRC has reached it maximum capacity as far as monkey housing, in part due to the addition of a 2 new colonies of Mauritian cynomolgus macaques and African green monkeys and the award of a NIAID SIV Vaccine Evaluation Unit award. The rationale for adding this particular type of housing is based on its versatility, low maintenance and cost savings on manpower: Located in Southern Louisiana, NIRC has the ability to house rhesus macaques outdoors year-round for breeding purposes, though the traditional corncrib cage design, while outstanding for sanitation and the behavioral development of macaques, with limited hierarchical stress, also has a number of drawbacks that the proposed new buildings will avoid, including the lack secondary containment, adequate protection for the occasional subzero days as recently experienced and a “rain tax” imposed by our municipal water ordinance. Corncrib housing currently supports breeding groups of up to 10 rhesus macaques in typical harem configuration with 1 male per corncrib. Use of larger runs as proposed, will enable the expansion of >1500 macaque breeders on site, maximizing utilization of proven breeder males. With over 8,500 nonhuman primates on site, NIRC is the largest primate facility in the US, and while not directly supported by NIH, has a rapidly expanding research program and readily available space for expansion, we submit that NIRC is an ideal site for expansion of macaque breeding in support of NIH research.", "keywords": [ "AIDS/HIV problem", "African Green Monkey", "Air", "Animals", "Antibody Therapy", "Award", "Behavioral", "Blood Circulation", "Breeding", "COVID-19 testing", "Colorectal", "Containment", "Cost Savings", "Development", "Electricity", "HIV", "Heating", "Housing", "Human Resources", "Louisiana", "Macaca", "Macaca fascicularis", "Macaca mulatta", "Maintenance", "Monkeys", "Mucous Membrane", "Municipalities", "National Institute of Allergy and Infectious Disease", "Pan Genus", "Pathogenesis", "Primates", "Rain", "Research", "Running", "SIV Vaccines", "Sanitation", "Signal Transduction", "Site", "Stress", "Taxes", "Testing", "Texas", "Therapeutic", "United States National Institutes of Health", "Universities", "Vaccines", "Vagina", "Viral", "Water", "base", "design", "experience", "imaging capabilities", "male", "microbicide", "nonhuman primate", "novel", "offspring", "pandemic disease", "prevent", "programs", "vaccine evaluation", "vaccine-induced antibodies" ], "approved": true } }, { "type": "Grant", "id": "10668", "attributes": { "award_id": "1C06OD034041-01", "title": "“Renovation of Building 29 laboratories at the New Iberia Research Center\"", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-19", "end_date": "2026-08-31", "award_amount": 2000000, "principal_investigator": { "id": 24751, "first_name": "Francois J", "last_name": "Villinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 707, "ror": "https://ror.org/01x8rc503", "name": "University of Louisiana at Lafayette", "address": "", "city": "", "state": "LA", "zip": "", "country": "United States", "approved": true }, "abstract": "The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette has undergone tremendous growth over the last 6 years adding some 3000 nonhuman primates for a current total of 9400 animals on site, and its research expenditure rose from ~19 to over 70 million between FY2016 and 2021. This expansion has been markedly accelerated during the COVID pandemic in 2 ways: 1) NIRC has supported the testing of no less than 12 COVID vaccines including the Pfizer-BioNTech as well as monitored the distribution and pharmacokinetics of convalescent antibodies via dynamic PET/CT imaging. 2) Owing to fact that many labs were closed across US institutions during 2020, NIRC scientists ensured that ongoing nonhuman primate experiments could be continued to avoid wasting precious resources. The expansion of NIRC’s in house HIV/AIDS research program is currently limited by the lack of additional research laboratory space to house new hires and their teams, with several candidates interested in joining NIRC and the University of Louisiana at Lafayette, which in December 2021 obtained the coveted R1 status by the Carnegie Commission on Institutions of Higher Education. In preparation of such laboratory expansion, NIRC has completed the demolition of the third floor of Building 29 (~9100 sq ft) along with complete and certified asbestos removal. This space will be ideal to house up to 6 research teams in a combination of open shared as well as separate laboratory spaces, complete with offices, cubicles and a conference room. NIRC supports many onsite and collaborative programs on using nonhuman primates on various metabolic and infectious diseases, most notably HIV lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to single cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the fight against COVID-19. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the breeding and the transfer of new programs such as the NIAID funded SVEU breeding program. In addition to over 6500 Indian origin rhesus macaques, NIRC is breeding and using Mauritian cynomolgus macaques and African green monkeys as well as a few pigtailed macaques. This NHP program is largely supported by a state-of-the-art onsite clinical laboratory, expert veterinary care and equipment. NIRC has also established an expandable rodent vivarium in the support of research and is planning to build a BSL-3 facility complete with laboratories, rodent and monkey housing. The addition of research laboratories at NIRC will markedly enhance the ability of the Center to assemble a critical mass of scientists focused on HIV research, expanding the breath of the research program fully supported by NHP models, and compete for external funding.", "keywords": [ "AIDS/HIV problem", "African Green Monkey", "Animals", "Antibodies", "Asbestos", "Breeding", "COVID-19", "COVID-19 pandemic", "Caring", "Clinical", "Colorectal", "Communicable Diseases", "Drug Kinetics", "Ensure", "Equipment", "Excision", "Expenditure", "Floor", "Funding", "Growth", "HIV", "Housing", "Institution", "Laboratories", "Laboratory Research", "Louisiana", "Macaca", "Macaca fascicularis", "Macaca mulatta", "Macaca nemestrina", "Metabolic Diseases", "Modeling", "Monitor", "Monkeys", "Mucous Membrane", "National Institute of Allergy and Infectious Disease", "PET/CT scan", "Pathogenesis", "Preparation", "Research", "Research Support", "Resources", "Rodent", "Scientist", "Site", "Testing", "Therapeutic", "Universities", "Vaccines", "Vagina", "Viral", "X-Ray Computed Tomography", "biosafety level 3 facility", "building renovation", "coronavirus disease", "experimental study", "fight against", "higher education", "imaging capabilities", "interest", "microbicide", "nonhuman primate", "pandemic disease", "prevent", "programs", "single cell analysis", "symposium", "wasting" ], "approved": true } }, { "type": "Grant", "id": "10577", "attributes": { "award_id": "1C06OD034103-01", "title": "Expansion and modification of animal housing and support spaces to increase production of the NIH U42 supported pigtailed macaque colony at Johns Hopkins University", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 11602, "first_name": "GUANGHU", "last_name": "Wang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-20", "end_date": "2027-05-31", "award_amount": 5500152, "principal_investigator": { "id": 24155, "first_name": "Eric Kenneth", "last_name": "Hutchinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "In the face of well-documented ongoing shortages of nonhuman primates for biomedical research and evidence that they may be a unique model for COVID-19, it is no surprise that the demand for pigtail macaques remains strong and continues to climb. Since the onset of NIH- support in 2006, the JHU pigtail macaque colony has provided 313 animals for biomedical research, the vast majority of which was HIV/AIDS related. With 172 of those animals (55%) going to NIH funded investigators at institutions outside of JHU, we have established our colony as an important national resource of this valuable animal model. To meet the growing need for pigtail macaques in biomedical research, we have developed a plan to significantly increase the number of animals that we can house at the JHU Research Farm and further refine our behavioral management of this breeding colony to improve productivity. First, we propose to construct an addition to the existing Building 12, significantly expanding animal housing and support spaces. This new construction will include animal housing space and innovative caging for 120 additional animals across 6 harems. This addition will also house dedicated support spaces, including an operating room, radiology room, flex holding space for convalescing or pre- sale animals, and a cage washing area, along with personnel spaces such as a staff locker room with connected showers, bathroom, laundry, and PPE donning/doffing area. Second, we propose to install underground fiber optic cable and other network infrastructure to connect the JHU Research Farm facilities to high-speed internet. This project will allow us to fully leverage the soon-to-be-installed JHU-funded upgrades to 1) security and 2) electronic animal health and behavior records. If this proposal is successful, we will better serve the NIH-funded research community that relies on primate models in two key ways: 1) we will increase the number of animals available to researchers and 2) we will evaluate the novel husbandry and behavioral management features designed into the new building and share our findings with NIH-funded nonhuman primate researchers and other national breeding centers.", "keywords": [ "AIDS/HIV problem", "Animal Housing", "Animal Model", "Animals", "Area", "Behavioral", "Biomedical Research", "Breeding", "COVID-19", "Communities", "Farm", "Fiber Optics", "Funding", "Health behavior", "Human Resources", "Institution", "Internet", "Macaca nemestrina", "Modeling", "Modification", "Network Infrastructure", "Operating Rooms", "Primates", "Production", "Productivity", "Radiology Specialty", "Records", "Research", "Research Personnel", "Resources", "Sales", "Security", "Speed", "United States National Institutes of Health", "Universities", "design", "improved", "innovation", "nonhuman primate", "novel" ], "approved": true } }, { "type": "Grant", "id": "6756", "attributes": { "award_id": "2U42OD011023-19", "title": "Husbandry and Management Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [], "start_date": "2002-09-30", "end_date": "2026-01-31", "award_amount": 863754, "principal_investigator": { "id": 21514, "first_name": "Joyce Kimberly", "last_name": "Cohen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 265, "ror": "https://ror.org/03czfpz43", "name": "Emory University", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Husbandry and Management Core The Yerkes National Primate Research Center (YNPRC) has a long and successful history of breeding rhesus macaques of Indian origin for HIV/AIDS research. This success can be attributed, in part, to continuous U24/U42 support for the management and care of this colony. Since 2002, this support has allowed the rhesus macaque breeding colony at the Yerkes NPRC Field Station to establish a colony pedigree, to transition to full SPF status, to institute MHC profiling, and to validate a rapid in-house Herpes B virus (Macacine herpesvirus 1) screening protocol. Over the past 4 years, the number of individual NIH-funded HIV/AIDS-related projects requiring SPF rhesus monkeys has remained relatively steady, and we are now seeing a post-COVID increase in animal requests. Thus, the main objective of the Husbandry and Management Core for the current U42 application is to leverage the resources provided by the U42 to maximize production of SPF Indian rhesus monkeys and facilitate allocation of these animals for NIH-funded HIV/AIDS research. As part of Aim 1, the Husbandry and Management Core will continue to maintain the SPF status and genetic health as well as the physical and social health of the Colony in order to produce high quality animals with desired MHC genotypes for HIV/AIDS research. As part of Aim 2 to maximize animal production potential, the Husbandry and Management Core will revise the strategies for improving the social competence of young future male breeders and for forming multi-male cohorts of breeders to improve the success of male introductions, and implement a social network analytical approach to assess stability in our large, compound-housed breeding groups, such as fragmentation in matrilines, to improve social stability and avoid the detrimental effect that social instability has on production. Finally, as part of Aim 3 to take an integrated approach to managing colony data sets, the Husbandry and Management Core will transition away from storing socialization and social behavioral datasets in compartmentalized spreadsheets to instead store them in the web-accessible Colony Informatics resource and implement a project management dashboard to facilitate manipulation and summary of data regarding animal availability, requests, and assignments to facilitate tracking and reporting. The success of these aims will ensure that the SPF colony at YNPRC will continue to grow and provide a reliable supply of healthy and genetically well-characterized rhesus macaques for HIV/AIDS research.", "keywords": [ "AIDS/HIV problem", "Animals", "Behavioral", "Breeding", "Caring", "Cercopithecine Herpesvirus 1", "Data", "Data Set", "Databases", "Eligibility Determination", "Employee", "Ensure", "Female", "Funding", "Future", "Genetic", "Genotype", "Growth", "Health", "Herpesvirus 1", "Human Resources", "Individual", "Institutes", "Macaca mulatta", "Maintenance", "Measures", "Performance", "Persons", "Population", "Prevention", "Primates", "Production", "Recording of previous events", "Reporting", "Research", "Research Personnel", "Research Subjects", "Resource Informatics", "Resources", "Risk", "Running", "Safety", "Social Network", "Socialization", "System", "United States National Institutes of Health", "Work", "cohort", "dashboard", "genetic pedigree", "high standard", "improved", "male", "post-COVID-19", "public health relevance", "reproductive", "social", "social skills", "success", "web-accessible" ], "approved": true } }, { "type": "Grant", "id": "6600", "attributes": { "award_id": "3R00AA024215-05S1", "title": "The role of serotonin signaling in the nucleus accumbens in excessive alcohol drinking", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 22119, "first_name": "Qi-Ying", "last_name": "Liu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-06-01", "end_date": "2023-05-31", "award_amount": 154500, "principal_investigator": { "id": 22120, "first_name": "Catherine Anne", "last_name": "Marcinkiewcz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": " DESCRIPTION (provided by applicant): Alcohol abuse is a significant public health burden that is often difficult to manage with current treatment options. Chronic intermittent ethanol (CIE can induce adaptations in neural circuits that govern anxiety and motivated behavior and may have relevance for ethanol dependence. The goal of this application is to dissect neural circuits that are critically involved in dependence induced escalations in ethanol drinking. Recent evidence indicates that both 5-HT2CR and kappa opioid receptor (KOR) in the nucleus accumbens (NAc) shell contribute to CIE enhanced drinking. My central hypothesis is that chronic intermittent ethanol (CIE) augments 5-HT release in the NAc, which activate local dynorphin neurons that in turn reduce dopamine release. This degrades the reward value of ethanol and leads to increased ethanol consumption. In Specific Aim 1, I will use a multiplexed DREADD strategy to delineate the role of 5HT inputs to the NAc shell in CIE induced elevations in voluntary ethanol drinking. In Specific Aim 2, I will examine the impact of CIE on excitability f dynorphin neurons using slice electrophysiology. Based on preliminary data that stimulation of NAc dynorphin neurons modulates dopamine release in the NAc, I will also use slice voltammetry to examine how CIE shapes dynorphin-dopamine interactions in the NAc. Specific Aim 3 is designed to clarify the role of these NAc dynorphin neurons in excessive ethanol drinking after CIE. In total, the proposed research will provide essential information concerning the actions of CIE on the 5-HT-dynorphin circuits in the NAc that specifically drive excessive alcohol consumption.", "keywords": [ "Air", "Alcohol abuse", "Alcohol consumption", "Alcohol dependence", "Alcohol withdrawal syndrome", "Alcoholism", "Alcohols", "Anxiety", "Automobile Driving", "Bathing", "Behavior", "Chronic", "Coupled", "Data", "Dependence", "Dopamine", "Dynorphins", "Electrophysiology (science)", "Ethanol", "Ethanol dependence", "Exposure to", "Frequencies", "Goals", "Heavy Drinking", "Hyperactivity", "Infusion procedures", "Investigation", "Left", "Membrane", "Messenger RNA", "Microdialysis", "Mus", "Neurons", "Nucleus Accumbens", "Opioid Antagonist", "Opioid agonist", "Outcome", "Pathogenesis", "Pharmacology Study", "Population", "Proteins", "Public Health", "Receptor Signaling", "Reporter", "Reporting", "Research", "Rewards", "Role", "Serotonin", "Shapes", "Signal Transduction", "Slice", "Techniques", "Testing", "Tracer", "Training", "Up-Regulation", "alcohol abuse therapy", "alcohol exposure", "alcohol seeking behavior", "alcohol use disorder", "base", "career", "design", "designer receptors exclusively activated by designer drugs", "drinking", "drinking behavior", "experimental study", "gamma-Aminobutyric Acid", "kappa opioid receptors", "motivated behavior", "neural circuit", "neuroadaptation", "optogenetics", "public health relevance", "response" ], "approved": true } } ], "meta": { "pagination": { "page": 1384, "pages": 1424, "count": 14236 } } }