Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1384&sort=end_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=end_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=end_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1385&sort=end_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1383&sort=end_date" }, "data": [ { "type": "Grant", "id": "12369", "attributes": { "award_id": "1R35GM150649-01", "title": "Small RNA-mediated warfare between viruses and their hosts", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22244, "first_name": "MICHAEL", "last_name": "SAKALIAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2028-08-31", "award_amount": 194250, "principal_investigator": { "id": 28303, "first_name": "Paulina", "last_name": "Pawlica", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Non-coding RNAs (ncRNAs) constitute the majority of RNAs present within the human cell, and are potent regulators of cellular processes, including translation, splicing, and post-transcriptional messenger RNA (mRNA) control. Like humans, viruses produce ncRNAs, whose functions are still largely unknown. Given that viruses evolved to maximize the information contained within their small genomes, all viral ncRNAs are postulated to be functional. Our lab studies the mechanisms by which small viral ncRNAs modulate host and viral processes, the knowledge of which will contribute to the development of new approaches to treat human disease. In the next five years, we will elucidate the roles of two distinct viral ncRNAs classes: small nuclear RNAs (snRNAs) expressed by an oncogenic g-herpesvirus (Project 1), and a microRNA (miRNA) produced by SARS-CoV-2, a virus that causes acute respiratory disease (Project 2). g-herpesviruses are DNA viruses, which during latency induce host cell transformation and oncogenesis. The latent viral genes produce several proteins and multiple ncRNAs. During its latency, herpesvirus saimiri, a classic g-herpesvirus, expresses seven snRNAs, known as HSURs. Unlike human snRNAs, HSURs were not linked to mRNA splicing, but instead to regulating host RNA levels in the cytoplasm. Interestingly, our results indicate that HSURs predominantly localize to the nucleus, where their roles remain unknown. Additionally, we observe that HSURs selectively translocate host cytoplasmic RNA-binding proteins into the nucleus. In Project 1, we will investigate the nuclear roles of viral snRNAs to explore unknown functions for host RNA-binding proteins and to gain insights into g-herpesviral transformation. SARS-CoV-2, a large RNA virus, is the causative agent of the coronavirus disease 2019 and the source of the current pandemic. We and others have recently discovered a miRNA expressed by SARS-CoV-2, named CoV-miR-O7a, which downregulates host genes involved inter alia in interferon signaling. Our preliminary data show that CoV-miR-O7a is abundantly present inside SARS-CoV-2 virions. We hypothesize that CoV-miR-O7a (and perhaps other ncRNAs) are selectively incorporated into virions to allow for early manipulation of host gene expression. In Project 2, we will investigate the mechanism and significance of viral miRNA incorporation into nascent virions to understand as yet unknown aspects of SARS-CoV-2 pathogenesis and to describe the previously unexplored way in which viruses inhibit host antiviral responses. Our multidisciplinary approaches, combined with the flexibility of MIRA funding, will lead to the establishment of a unique research program centered around understanding of small RNA biology in the context of viral infection. In elucidating functions of small viral ncRNAs, this study will advance the fields of RNA biology and virology. Such knowledge can lead to identification of novel targets for treatment of viral disease, including virally-induced cancers.", "keywords": [ "2019-nCoV", "Acute", "Antiviral Response", "Biology", "COVID-19", "Cell Nucleus", "Cell physiology", "Cells", "Coronavirus", "Cytoplasm", "DNA Viruses", "Data", "Development", "Funding", "Gene Expression", "Genes", "Genome", "Herpesviridae", "Human", "Interferons", "Knowledge", "Mediating", "Messenger RNA", "MicroRNAs", "Molecular", "Names", "Nuclear", "Oncogenic", "Pathway interactions", "Process", "Proteins", "RNA", "RNA Splicing", "RNA Viruses", "RNA Messenger Splicing", "RNA-Binding Proteins", "Research", "Respiratory Disease", "Role", "SARS-CoV-2 pathogenesis", "Saimiriine Herpesvirus 2", "Signal Transduction", "Small Nuclear RNA", "Small RNA", "Source", "Transcript", "Translations", "Untranslated RNA", "Viral", "Viral Genes", "Virion", "Virus", "Virus Diseases", "Virus Latency", "cell transformation", "current pandemic", "flexibility", "human disease", "insight", "interdisciplinary approach", "novel", "novel strategies", "posttranscriptional", "programs", "tumorigenesis", "virology", "virus related cancer" ], "approved": true } }, { "type": "Grant", "id": "12372", "attributes": { "award_id": "1R01AA030470-01A1", "title": "Testing an mHealth System for Integrating Alcohol Use Treatment with Hepatology Care for Patients with Alcohol-associated Liver Disease", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20919, "first_name": "Svetlana", "last_name": "Radaeva", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2028-08-31", "award_amount": 630575, "principal_investigator": { "id": 28306, "first_name": "Randall T", "last_name": "Brown", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28307, "first_name": "Jessica Leigh", "last_name": "Mellinger", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28308, "first_name": "Andrew", "last_name": "Quanbeck", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 799, "ror": "", "name": "UNIVERSITY OF WISCONSIN-MADISON", "address": "", "city": "", "state": "WI", "zip": "", "country": "United States", "approved": true }, "abstract": "Alcohol-associated liver disease (ALD) rates have risen markedly over the past 15 years, becoming the most common indication for liver transplantation in the U.S. and generating the majority of healthcare and cost burden among all liver diseases. With the COVID pandemic, these trends have worsened, and it is estimated that, if nothing is done to stem the tide, ALD-related mortality will double by 2040. Despite decades of medical research, alcohol cessation remains the only intervention that substantially decreases long-term ALD morbidity and mortality. However, only 10-15% of ALD patients access alcohol use treatment in the first year after their diagnosis, with women even less likely to access treatment compared to men. Despite these gaps, surprisingly few behavioral interventions for alcohol cessation have been tested in ALD patients, and, of those that have been tested, integrated alcohol cessation treatment alongside medical and hepatology care has had the most impact at reducing alcohol use. To address these critical research gaps, the investigators will perform a randomized, controlled, Type 1 hybrid implementation-effectiveness trial in a population of ALD patients to evaluate the effectiveness of CHESS Health Connections (a smartphone app for alcohol cessation shown to significantly reduce risky drinking in a prior randomized clinical trial of patients with severe alcohol use disorder). Patients will be enrolled in both general hepatology and multidisciplinary ALD clinics (which include integrated alcohol use treatment professionals alongside hepatology providers) at two large tertiary care centers (University of Wisconsin and University of Michigan). Aim 1 will compare the effectiveness of CHESS plus usual care (n=180) versus usual care (n=181) on days of abstinence over 6 months. Aim 2 will assess implementation of CHESS through qualitative interviews of key patient, provider, and clinic-level stakeholders using the Replicating Effective Programs framework and implementation costs. Our secondary/exploratory analyses will examine intervention effects on health outcomes including depression, anxiety, insomnia, AUD treatment engagement, and liver health. We will examine key moderators (age, sex, rurality, presence of formal AUD treatment, and stage of ALD) and mediators (relatedness, competence, autonomous motivation) on outcomes. We will also examine the impact of the CHESS app on measures of chronic liver impairment using the Model for End-Stage Liver Disease-Sodium score. This study will build on over a decade of work in adapting and using CHESS in various populations with alcohol use disorder. This study is highly innovative in three ways: 1) it is the first fully powered effectiveness trial of a proven smartphone app for alcohol cessation in ALD patients, 2) it will test a new model of care for delivering alcohol cessation treatment to ALD patients, and 3) it will utilize a novel collaboration of systems engineering and medical researchers with expertise in ALD, digital health, and implementation science. If successful, this study holds promise to provide critically needed alcohol use resources to ALD patients and potentially set a new standard of care.", "keywords": [ "Abstinence", "Address", "Adoption", "Age", "Alcohol consumption", "Alcoholic Hepatitis", "Alcoholic Liver Diseases", "Alcohols", "Anxiety", "Behavior Therapy", "Behavioral", "Blood Tests", "COVID-19 pandemic", "Caring", "Cessation of life", "Chronic", "Cirrhosis", "Clinic", "Collaborations", "Competence", "Computerized Medical Record", "Cost Effectiveness Analysis", "Cost Measures", "Counseling", "Critical Care", "Data", "Decision Making", "Diagnosis", "Diagnostic", "Disease", "Effectiveness", "Engineering", "Enrollment", "Goals", "Health", "Health Care Costs", "Health Sciences", "Health Services Accessibility", "Healthcare", "Heavy Drinking", "Hepatology", "Hybrids", "Impairment", "Intervention", "Interview", "Liver", "Liver diseases", "Measurement", "Measures", "Mediator", "Medical", "Medical Research", "Medical center", "Mental Depression", "Mental Health", "Michigan", "Mobile Health Application", "Modeling", "Monitor", "Morbidity - disease rate", "Motivation", "National Institute on Alcohol Abuse and Alcoholism", "Outcome", "Patient Care", "Patient-Focused Outcomes", "Patients", "Persons", "Pharmacotherapy", "Population", "Prognosis", "Provider", "Quality-Adjusted Life Years", "Randomized", "Randomized Controlled Trials", "Replicating Effective Programs", "Research", "Research Personnel", "Resources", "Self Management", "Sleeplessness", "Sodium", "Specialist", "Strategic Planning", "Substance Use Disorder", "Substance abuse problem", "System", "Testing", "United States", "Universities", "Wisconsin", "Woman", "Work", "alcohol abstinence", "alcohol abuse therapy", "alcohol availability", "alcohol intervention", "alcohol testing", "alcohol use disorder", "behavior change", "compare effectiveness", "cost comparison", "digital health", "effectiveness evaluation", "effectiveness trial", "effectiveness/implementation trial", "end stage liver disease", "evidence base", "high risk drinking", "implementation cost", "implementation evaluation", "implementation science", "improved", "improved outcome", "innovation", "intervention effect", "liver transplantation", "mHealth", "men", "mortality", "multidisciplinary", "novel", "pandemic disease", "patient engagement", "patient population", "peer support", "primary outcome", "public health emergency", "randomized clinical trials", "reduced alcohol use", "routine provider", "rurality", "sex", "smartphone applicatio" ], "approved": true } }, { "type": "Grant", "id": "12379", "attributes": { "award_id": "1U54CA285117-01", "title": "Project 2: The Intersection of Telehealth and Health Disparities in At-Risk Older Patients with Cancer", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2023-09-19", "end_date": "2028-08-31", "award_amount": 244545, "principal_investigator": { "id": 28315, "first_name": "Melody K", "last_name": "Schiaffino", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 775, "ror": "https://ror.org/0264fdx42", "name": "San Diego State University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "PROJECT SUMMARY/ ABSTRACT – PROJECT 2 Telehealth utilization increased rapidly across the US healthcare system in response to the COVID-19 pandemic. As we emerge from the pandemic, telehealth has become a new option for communication between patients and providers. Cancer care delivery appears well positioned to incorporate telehealth into the standard workflow of patient care. Furthermore, equitable implementation of telehealth could potentially increase access to care among vulnerable patients. However, emerging data suggest disparities with telehealth utilization access among non-White, low income, and non-English speaking individuals. Inequitable implementation of telehealth could inadvertently create barriers among our most vulnerable patients, which could paradoxically increase cancer health disparities. Large-scale rigorous research evaluating disparities in telehealth utilization within the post-COVID-19 cancer care environment is lacking. Furthermore, research has not addressed how telehealth utilization influences safety and quality of care compared to conventional in-person visits, particularly among our at-risk populations with higher baseline risks of poor outcomes and adverse events. Finally, a comprehensive understanding of telehealth disparities requires an understanding of patient perceptions and provider biases towards telehealth, which represent important unaddressed questions. To fill these critical knowledge gaps, we propose a comprehensive population-based cohort study among Medicare beneficiaries with cancer, incorporating linkages to secondary datasets providing data on providers, hospitals, and regional factors. We will assess the impact of telehealth on vulnerable cancer populations through the following aims: 1) identify and characterize disparities in telehealth during and after the COVID-19 pandemic; 2) assess the impact of telehealth on efficacy and safety of cancer delivery among at-risk populations; and 3) define actionable patient-level barriers and provider biases with telehealth utilization. This proposed study will help define the national landscape of telehealth among cancer patients, and will provide a framework for the development of future interventions to optimize telehealth among at-risk patients. This timely project will deliver actionable information to providers, healthcare systems, and policymakers. Overall, equitable, safe, and effective telehealth delivery stands to increase access to care and reduce cancer health disparities among our most vulnerable cancer patients.", "keywords": [ "Address", "Adverse event", "COVID-19 pandemic", "California", "Cancer Patient", "Caring", "Catchment Area", "Cohort Studies", "Communication", "Complement", "County", "Data", "Data Set", "Databases", "Development", "Disparity", "Elderly", "Emergency department visit", "Environment", "Equity", "Ethnic Origin", "Future", "Health Services Accessibility", "Health system", "Healthcare", "Healthcare Systems", "Hospitalization", "Hospitals", "Household", "Improve Access", "Income", "Individual", "Inequality", "Inequity", "Internet", "Intervention", "Knowledge", "Language", "Link", "Logistic Regressions", "Low income", "Malignant Neoplasms", "Medicare", "Medicare claim", "Medicare/Medicaid", "Methods", "Modeling", "Oncology", "Outcome", "Patient Care", "Patient-Focused Outcomes", "Patients", "Perception", "Persons", "Policies", "Policy Maker", "Population", "Populations at Risk", "Positioning Attribute", "Provider", "Quality of Care", "Race", "Research", "Risk", "Safety", "Secondary to", "Socioeconomic Status", "Surveys", "Technology", "Telecommunications", "Testing", "Visit", "Vulnerable Populations", "access disparities", "adverse outcome", "anticancer research", "beneficiary", "cancer care", "cancer education", "cancer health disparity", "cancer risk", "care delivery", "care outcomes", "disparity reduction", "ethnic minority", "experience", "health disparity", "health equity", "improved", "interest", "marginalized population", "neoplasm registry", "older patient", "pandemic disease", "patient population", "patient-level barriers", "population based", "post-COVID-19", "provider-level barriers", "racial minority", "response", "telehealth" ], "approved": true } }, { "type": "Grant", "id": "12383", "attributes": { "award_id": "1R24AI165424-01A1", "title": "Establishment of a Bat Resource for Infectious Disease Research", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 7711, "first_name": "SARA ELAINE", "last_name": "Woodson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-22", "end_date": "2028-08-31", "award_amount": 1694054, "principal_investigator": { "id": 859, "first_name": "Jonathan H", "last_name": "Epstein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 234, "ror": "", "name": "Ecohealth Alliance inc.", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 22678, "first_name": "William A", "last_name": "Schountz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 323, "ror": "https://ror.org/03k1gpj17", "name": "Colorado State University", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 323, "ror": "https://ror.org/03k1gpj17", "name": "Colorado State University", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract Bats are reservoirs, or suspected reservoirs, of many zoonotic viruses, including SARS, SARS2 and MERS coronaviruses, Nipah and Hendra viruses, and Ebola and Marburg viruses. Little is known about how these viruses circulate in their bat reservoirs, principally because of a lack of bat colonies that can be used for the development of experimental infection models. To address this deficiency, we will capture horseshoe bats and Indian flying foxes, respective reservoir hosts of Nipah virus and SARS-related coronaviruses, in Bangladesh where they will be quarantined and provided veterinary care as they adapt to captivity. Bats will be shipped to CSU to establish the breeding colonies as a resource for investigators who study these viruses. We will generate primary cell cultures and immortalized cell lines from various tissues and freeze live bone marrow that will be useful for studying how these viruses infect bat cells, and how the viruses may modulate the innate immune responses. Recombinant cytokines will also be produced for the research community, including those for generating macrophages and dendritic cells (GM-CSF, Flt3L), T cells (IL-2) and for in vivo modulation of the adaptive immune response (IFN, IL-4). Moreover, we will generate monoclonal antibodies for use in cytokine detection assays and flow cytometry of immune cell subsets and in vivo neutralization. Finally, we will perform experimental infection studies of Nipah virus, SARS-CoV-2 and the SARS-related coronavirus, RaTG13, to study the infection kinetics, virus distribution and transcriptomic, proteomic and metabolomic profiles of bats during infection, and escalation and resolution of the immune response. Tissues, cells and sera from naïve and infected bats will be archived in a biobank that will be made available to the research community. The establishment of this resource will lead to a better understanding of how bats host highly pathogenic viruses without disease and may shed light on events that increase spillover risks to humans. In turn, this information could lead to development of mitigation strategies to prevent future virus spillover and uncover new strategies for therapeutic treatment of coronavirus and Nipah virus diseases.", "keywords": [ "2019-nCoV", "Address", "Affect", "Animal Model", "Animals", "Archives", "Asia", "Bangladesh", "Biology", "Bone Marrow", "Breeding", "Caring", "Cell Culture Techniques", "Cell Line", "Cells", "Chiroptera", "Clinical", "Colorado", "Communities", "Coronavirus", "Coronavirus Infections", "Dendritic Cells", "Development", "Disease", "Disease Outbreaks", "Ebola virus", "Encephalitis", "Event", "FLT3 ligand", "Family Pteropodidae", "Filovirus", "Flow Cytometry", "Freezing", "Future", "Genus Pteropus", "Granulocyte-Macrophage Colony-Stimulating Factor", "Health", "Hendra Virus", "Henipavirus", "Henipavirus Infections", "Hepatitis C virus", "Human", "Immune", "Immune response", "Immunology", "In Vitro", "Individual", "Infection", "Infection Control", "Infectious Diseases Research", "Innate Immune Response", "Interleukin-2", "Interleukin-4", "Kinetics", "Knowledge", "Laboratories", "Macrophage", "Mammals", "Marburgvirus", "Measles", "Methodological Studies", "Middle East Respiratory Syndrome Coronavirus", "Modeling", "Monoclonal Antibodies", "Mumps", "Natural Immunity", "Nipah Virus", "Outcome", "Paramyxovirus", "Pathogenicity", "Pathology", "Physiology", "Predisposition", "Primary Cell Cultures", "Proteins", "Proteomics", "Quarantine", "Reagent", "Recombinant Cytokines", "Recombinant Proteins", "Research", "Research Personnel", "Resolution", "Resources", "Risk", "SARS coronavirus", "Sarbecovirus", "Severe Acute Respiratory Syndrome", "Study models", "Surface Antigens", "T-Lymphocyte", "Testing", "Therapeutic", "Tissues", "Universities", "Viral", "Virus", "Virus Diseases", "Work", "Zoonoses", "adaptive immune response", "bat-borne", "betacoronavirus", "biobank", "cell immortalization", "coronavirus treatment", "cytokine", "deep sequencing", "detection assay", "experimental study", "germ free condition", "improved", "in vitro testing", "in vivo", "metabolomics", "mortality", "novel", "novel therapeutic intervention", "offspring", "pandemic potential", "pathogen", "pathogenic virus", "prevent", "trait", "transcriptomics" ], "approved": true } }, { "type": "Grant", "id": "12400", "attributes": { "award_id": "1R50CA278859-01", "title": "Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 28342, "first_name": "ONN WOLF WOLF", "last_name": "Lindwasser", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-19", "end_date": "2028-08-31", "award_amount": 160532, "principal_investigator": { "id": 28343, "first_name": "Nina Delaney", "last_name": "Wagner-Johnston", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Both the impacts from COVID-19 as well as the increasing complexities of clinical trials, with a particular emphasis on precision medicine trials, have led to a recent decline in enrollments. This proposal identifies strategies to address the challenges of enhancing clinical trial enrollments in the hematologic malignancies (HM) program at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The two-pronged approach tackles system barriers and patient barriers. A clinical trial toolkit will be developed to address systems barriers with the goal of minimizing inefficiencies within our research operations program, increasing enrollment, and ultimately creating a clinical trial portfolio that best serves our patients. Components of the toolkit include metrics to ensure feasibility of trials, establish a prioritization queue for resourcing potential studies, trackers for effort and finances, and performance standards. With many patients preferring to receive their care closer to home, while also having access to the same novel approaches offered at academic medical centers, the proposal seeks to extend our clinical research studies to satellite sites. To achieve that end, Dr. Wagner-Johnston addresses strategies to create the necessary research culture to enhance enrollment. Focus will be placed on establishing leadership and providing a collaborative learning culture at the satellite sites. Rational portfolio building at the satellite sites will rely on the same metrics developed as part of the toolkit. Engagement from both physicians and prospective trial participants is essential and this proposal outlines practical approaches to attend to these concerns. Involvement in routine research meetings and recognition of physicians' effort in consenting to trials will incentivize trial participation. Outreach efforts including monthly email newsletters to referring physicians, updates to our HM website, as well as a better tool to identify potential trials for patients are planned. We will extend the ongoing work of community health educators affiliated with projects initiated by the Diversity and Inclusion in Clinical Research Program at SKCCC to include our patients with HM. The outlined research strategy seeks to improve the operational aspects beginning with pre-trial activation through study closure. Attention to increased efficiencies will be essential in bringing needed research to satellite sites. Best practices identified from this project will be readily transferrable to the entire cancer center enterprise at SKCCC and shared with other academic medical centers. As a nationally recognized lymphoma expert with a strong commitment to the NCTN and extensive knowledge in clinical research operations, Dr. Wagner-Johnston is poised to lead these efforts and successfully enhance accruals.", "keywords": [ "Academic Medical Centers", "Address", "Attention", "Award", "COVID-19 impact", "Cancer Center", "Caring", "Clinical Research", "Clinical Trials", "Community Health", "Comprehensive Cancer Center", "Consent", "Development", "Electronic Mail", "Enrollment", "Ensure", "Goals", "Health Educators", "Health system", "Hematologic Neoplasms", "Home", "Incentives", "Knowledge", "Lead", "Leadership", "Learning", "Lymphoma", "Newsletter", "Oncology", "Operations Research", "Participant", "Patients", "Performance", "Physicians", "Precision medicine trial", "Research", "Research Proposals", "Resources", "Site", "System", "Therapeutic Trials", "Time", "Update", "Work", "clinical trial enrollment", "diversity and inclusion", "feasibility trial", "improved", "meetings", "novel strategies", "operation", "outreach", "patient-level barriers", "programs", "prospective", "research study", "tool", "web site" ], "approved": true } }, { "type": "Grant", "id": "12411", "attributes": { "award_id": "1K01HD110683-01A1", "title": "State economic support policies on the prevention of child abuse and neglect during and post the COVID-19 pandemic: Bridging evidence with policy implementation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 27515, "first_name": "LEAH KAYE", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-21", "end_date": "2028-08-31", "award_amount": 132381, "principal_investigator": { "id": 28356, "first_name": "Liwei", "last_name": "Zhang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 827, "ror": "", "name": "WASHINGTON UNIVERSITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "Child abuse and neglect (CAN) is a pressing and costly public health issue with negative lifelong consequences. Children living in economically disadvantaged families and communities are at high risk for experiencing CAN or receiving CAN reports. Though not all types of CAN are preventable, theories and empirical studies suggest policies strengthening economic security may be potentially effective strategies to prevent a significant portion of CAN by improving caregiving capacity and parental well-being. The COVID-19 pandemic (hereafter, COVID) has exacerbated economic hardship and parental stress, creating additional risks related to CAN. To address material hardship and health inequity, states with differing contexts developed or expanded innovative economic support policies, with various approaches in timing, policy selection, and implementation. Understanding how COVID-related policy changes impacted CAN is essential to inform the design of CAN prevention strategies in the COVID-recovery era and plan for future disasters. Further, central to recovery from COVID (and other similar disasters) is the mobilization of community resources and collective actions by community members. Although the goal of macro-level policy evaluation is to improve community-based CAN prevention practices, little effort has been made to engage local communities in the identification and implementation of community-based policies. Leveraging a natural experimental design with nationwide data, along with a community-based participatory design, this study will 1) examine how changes in state-based economic support policies during and post COVID, individually and in synergy with each other, impact CAN report and related family stressors; 2) investigate how states' policy effects vary by county poverty rate, racial/ethnic composition, and rural/urban status; 3) engage families and service providers in how policies are implemented at the local level with the aim to identify effective CAN prevention strategies in local community settings. To accomplish the proposed project goals, the PI will receive mentorship from a group of interdisciplinary experts, including Drs. Melissa Jonson-Reid, Derek Brown, and Patricia Kohl, take full advantage of the extensive resources at the NIH-funded Center for Innovation in Child Maltreatment Policy, Research and Training (P50HD096719), and extend existing partnerships with community stakeholders in Missouri. The PI will receive training in 1) performing policy evaluations with rigorous causal inference methodologies; 2) managing and analyzing large-scale ecological data; 3) conducting community-based participatory research; 4) developing NIH grants and disseminating research evidence for CAN prevention. This K01 award will enable the PI to conduct independent, community-engaged, and policy-relevant research informing states' selection and implementation of policies to prevent CAN.", "keywords": [ "Address", "Advocacy", "COVID-19 pandemic", "Child", "Child Abuse and Neglect", "Child abuse prevention", "Collaborations", "Communities", "Community Actions", "County", "Data", "Data Analyses", "Data Linkages", "Disasters", "Economics", "Ethnic Origin", "Experimental Designs", "Family", "Food", "Funding", "Future", "Goals", "Grant", "Housing", "Individual", "Mentored Research Scientist Development Award", "Mentors", "Mentorship", "Methodology", "Missouri", "Natural experiment", "Personal Satisfaction", "Policies", "Policy Analysis", "Poverty", "Prevention", "Prevention strategy", "Process", "Public Health", "Race", "Recovery", "Reporting", "Research", "Research Activity", "Research Personnel", "Resources", "Risk", "Rural", "Security", "Series", "Stress", "Training", "Translating", "United States National Institutes of Health", "Variant", "Visit", "caregiving", "community based participatory research", "community based practice", "community engagement", "community setting", "complex data", "coronavirus disease", "cost", "design", "economic disparity", "experience", "flexibility", "future pandemic", "health inequalities", "high risk", "improved", "innovation", "knowledge base", "kohl", "member", "neglect", "people of color", "post-COVID-19", "prevent", "prevention practice", "programs", "service providers", "socioeconomics", "stressor", "success", "synergism", "theories" ], "approved": true } }, { "type": "Grant", "id": "14833", "attributes": { "award_id": "7K01HD110683-02", "title": "State economic support policies on the prevention of child abuse and neglect during and post the COVID-19 pandemic: Bridging evidence with policy implementation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 27515, "first_name": "LEAH KAYE", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-12-01", "end_date": "2028-08-31", "award_amount": 132381, "principal_investigator": { "id": 28356, "first_name": "Liwei", "last_name": "Zhang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 888, "ror": "https://ror.org/00te3t702", "name": "University of Georgia", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Child abuse and neglect (CAN) is a pressing and preventable public health issue with negative lifelong consequences, including early deaths. Children living in economically disadvantaged families and communities are at high risk for CAN. Economic support policies may be effective strategies towards reducing CAN through strengthening families' financial well-being and reducing related stress. Because states vary in policy selection and implementation (e.g., eligibility and spending), understanding the effects of varying state-level economic support policies can inform the larger-scale implementation of economic policies to prevent CAN. Yet, there is a lack of research examining the causal effects of state economic support policies on CAN prevention. Also, little effort has been made to bridge macro-level policy evaluation with community-based CAN prevention strategies. Since the Covid-19 pandemic, many states have adjusted pre-existing programs and enacted Covid-related support policies (e.g., eviction moratoria and extended unemployment benefits). Evaluating the impact of changing policies on CAN during pre- Covid, Covid, and Covid-recovery eras can help determine how to direct economic support resources to families at risk of CAN during recovery and plan for future disasters. Leveraging a natural experimental design with nationwide data, along with a community-based participatory design, this study will 1) identify and synthesize state-level economic support policies during pre-Covid, Covid, and Covid-recovery eras, to examine how these policies, individually and in synergy with each other, impact county-level CAN report rates; 2) investigate how states' policy effects on CAN are mediated by county-level poverty and unemployment rates, and whether the effects vary by age, gender, race/ethnicity, rural/urban status, and CAN subtype; 3) develop and implement advocacy strategies with local communities to increase access to empirically informed economic support services that prevent CAN. To accomplish the proposed project goals, the PI will receive mentorship from a group of interdisciplinary experts, including Drs. Melissa Jonson-Reid, Derek Brown, and Patricia Kohl, take full advantage of the extensive resources at the NIH-funded Center for Innovation in Child Maltreatment Policy, Research and Training (P50HD096719), and extend existing partnerships with community stakeholders in St. Louis, Missouri. The PI will receive training in 1) performing policy evaluations with rigorous causal inference methodologies; 2) managing and analyzing large-scale ecological data; 3) conducting community-based participatory research; 4) developing NIH grants and disseminating research evidence for CAN prevention. This K01 award will enable the PI to conduct independent, community-engaged, and policy-relevant research informing states' selection and implementation of policies to prevent CAN.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15206", "attributes": { "award_id": "1R01OH012583-01A1", "title": "Advanced Personal Sampler to Assess Occupational Exposures to Bioaerosols", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute for Occupational Safety and Health (NIOSH)" ], "program_reference_codes": [], "program_officials": [ { "id": 24462, "first_name": "BRIDGETTE E", "last_name": "GARRETT", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-01", "end_date": "2028-08-31", "award_amount": 353356, "principal_investigator": { "id": 26418, "first_name": "Taewon T", "last_name": "Han", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 26419, "first_name": "GEDIMINAS", "last_name": "MAINELIS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1732, "ror": "", "name": "RUTGERS, THE STATE UNIV OF N.J.", "address": "", "city": "", "state": "NJ", "zip": "", "country": "United States", "approved": true }, "abstract": "This grant application responds to PAR-18-812: Occupational Safety and Health Research (R01). Exposure to airborne biological agents is known to cause a wide range of negative health effects in occupational and general populations. Thus, advanced exposure assessment tools are needed. The proposed project will complete the development and testing of a novel, standalone, battery-operated personal electrostatic bioaerosol sampler (PEBS) featuring a high sample concentration rate. In the completed PEBS, bioaerosols will be drawn into an open channel collector at 20 L/min, electrically charged, and deposited inside a removable cartridge with a hydrophobic collection plate. The collected particles will be eluted into 0.5 mL of liquid using a newly designed elution station. The eluate can then be analyzed by various techniques, from culturing to molecular tools, sequencing, and rapid analysis kits. In the exploratory research, we demonstrated the feasibility of this personal sampler concept and built its prototype. This R01 project will complete the sampler’s development, including integration with electronic components and controls and the elution station. The completed sampler version will quadruple the sample concentration rate compared to the prototype. The performance of PEBS will be validated using different microorganisms, including coronavirus OC43, and multiple microbial analysis techniques. The standalone PEBS will be rigorously tested against other personal samplers, including its use in the field to determine actual personal bioaerosol exposures in various occupational environments. We hypothesize that the standalone PEBS is advantageous over current personal bioaerosol samplers in determining bioaerosol exposures, especially at low microorganism concentrations. This proposal responds to NORA’s Priority Research Agendas National Agriculture, Forestry, and Fishing; National Services; National Transportation, Warehousing, and Utilities by answering their call to improve exposure assessment to occupational agents (e.g., biological agents) and to prevent and reduce work-related illnesses, including respiratory infectious diseases and asthma. The proposal also responds to several cross-sector programs, e.g., Respiratory Health and Immune, Dermal & Infectious Diseases. This proposal responds to the NIOSH r2P initiative by developing an innovative tool that will enable an improved assessment of personal exposures to biological air contaminants, leading to worker health protection. The new personal sampling technology will eventually be transferred into the workplace. The study output will be an advanced standalone personal bioaerosol sampler for occupational environments and publications/presentations describing the technology and its performance and application. We expect that intermediate outcomes will include a patent, citations in the literature, and, finally, adoption of the sampler in practice. The end outcome is expected to be a better understanding of personal exposures to hazardous biological particles, eventually leading to better health protection.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15383", "attributes": { "award_id": "1R01DA059457-01A1", "title": "A Growing Crisis of Novel Injection-Related Wounds and Skin & Soft Tissue Infections among People Who Inject Drugs: A Community-Based, Longitudinal Investigation in North Carolina", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 23652, "first_name": "MELISA RAY", "last_name": "Creamer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-30", "end_date": "2028-08-31", "award_amount": 661013, "principal_investigator": { "id": 31983, "first_name": "Jon Eric", "last_name": "Zibbell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 809, "ror": "", "name": "RESEARCH TRIANGLE INSTITUTE", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "We propose a community-based, longitudinal, mixed-methods study to investigate the growing crisis of injection-related wounds and skin and soft tissue infections (IWSSTIs) among people who inject drugs (PWID) in the United States. Lost among the data on skyrocketing overdose deaths is an alarming increase in the prevalence and severity of novel IWSSTIs. IWSSTIs are a leading cause of morbidity for PWID and the most common cause of hospitalizations. More than 100,000 IWSSTIs have occurred annually since 2018. When left untreated, IWSSTIs can become septic, gangrene, and progress to catastrophic infections that require complicated surgeries and long-term medical care. IWSSTIs can stress hospital systems already overburdened with COVID-19, consume limited Medicaid funding, and increase stigma toward PWID. While IWSSTIs have been a concern for PWID for decades, rising incidence of dermal reactions and antinociceptive effects from synthetic drugs and novel psychoactive substances (NPS) represents a new and emerging public health crisis. The Office of National Drug Control Policy recently listed xylazine as an emerging threat and the Centers for Disease Control and Prevention warned of xylazine’s growing involvement in fentanyl overdose deaths. Aim 1: To observe, examine, and typologize IWSSTIs by DSS factors through Consensus-based Clinical Case Reporting Guideline Development (CARE)26-informed case reports, ethnographic interviews, and community-based drug checking among a qualitative sample of 30 PWID (15/site) in western NC; Aim 2: To examine associations between DSS factors and IWSSTI risk among a longitudinal cohort of PWID in NC (N = 450). To achieve these aims, we will recruit PWID from SSPs, homeless encampments, motels, and other places where PWID reside and congregate at the two study sites and surrounding counties (see Facilities). Aim 1 will be accomplished using targeted sampling methods and Aim 2 will be accomplished using respondent-driven sampling (RDS). The study will be led by Principal Investigator Jon Zibbell, a National Institute on Drug Abuse (NIDA)–funded behavioral scientist with many years of experience studying injection drug use and infectious disease risk among PWID. The team also includes William Zule, a NIDA-funded epidemiologist; Arnie Aldridge, a National Institutes of Health–funded statistician; Asher Schranz, a physician and medical expert in injection-related infectious diseases; and Sarah Duhart Clarke, an applied psychologist. Findings from the proposed study will help characterize the etiology and unique features of IWSSTs by DSS factors and quantify xylazine prevalence in the illicit drug supply in western NC. Because growing xylazine contamination and sharp growth in novel IWSSTIs among PWID together comprise an emerging crisis, these data are time sensitive, and the proposed study is poised to make a timely and effective contribution to inform public health response.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15428", "attributes": { "award_id": "5K01HD110683-03", "title": "State economic support policies on the prevention of child abuse and neglect during and post the COVID-19 pandemic: Bridging evidence with policy implementation", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 27515, "first_name": "LEAH KAYE", "last_name": "Gilbert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-12-01", "end_date": "2028-08-31", "award_amount": 132381, "principal_investigator": { "id": 28356, "first_name": "Liwei", "last_name": "Zhang", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 888, "ror": "https://ror.org/00te3t702", "name": "University of Georgia", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Child abuse and neglect (CAN) is a pressing and costly public health issue with negative lifelong consequences. Children living in economically disadvantaged families and communities are at high risk for experiencing CAN or receiving CAN reports. Though not all types of CAN are preventable, theories and empirical studies suggest policies strengthening economic security may be potentially effective strategies to prevent a significant portion of CAN by improving caregiving capacity and parental well-being. The COVID-19 pandemic (hereafter, COVID) has exacerbated economic hardship and parental stress, creating additional risks related to CAN. To address material hardship and health inequity, states with differing contexts developed or expanded innovative economic support policies, with various approaches in timing, policy selection, and implementation. Understanding how COVID-related policy changes impacted CAN is essential to inform the design of CAN prevention strategies in the COVID-recovery era and plan for future disasters. Further, central to recovery from COVID (and other similar disasters) is the mobilization of community resources and collective actions by community members. Although the goal of macro-level policy evaluation is to improve community-based CAN prevention practices, little effort has been made to engage local communities in the identification and implementation of community-based policies. Leveraging a natural experimental design with nationwide data, along with a community-based participatory design, this study will 1) examine how changes in state-based economic support policies during and post COVID, individually and in synergy with each other, impact CAN report and related family stressors; 2) investigate how states' policy effects vary by county poverty rate, racial/ethnic composition, and rural/urban status; 3) engage families and service providers in how policies are implemented at the local level with the aim to identify effective CAN prevention strategies in local community settings. To accomplish the proposed project goals, the PI will receive mentorship from a group of interdisciplinary experts, including Drs. Melissa Jonson-Reid, Derek Brown, and Patricia Kohl, take full advantage of the extensive resources at the NIH-funded Center for Innovation in Child Maltreatment Policy, Research and Training (P50HD096719), and extend existing partnerships with community stakeholders in Missouri. The PI will receive training in 1) performing policy evaluations with rigorous causal inference methodologies; 2) managing and analyzing large-scale ecological data; 3) conducting community-based participatory research; 4) developing NIH grants and disseminating research evidence for CAN prevention. This K01 award will enable the PI to conduct independent, community-engaged, and policy-relevant research informing states' selection and implementation of policies to prevent CAN.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1384, "pages": 1442, "count": 14420 } } }