Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1384&sort=-awardee_organization
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-awardee_organization", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=-awardee_organization", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1385&sort=-awardee_organization", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1383&sort=-awardee_organization" }, "data": [ { "type": "Grant", "id": "14425", "attributes": { "award_id": "2119844", "title": "Collaborative Research: Probing feedbacks between thermal structure, petrologic transformation, and rheologic evolution within dynamically evolving subduction zones", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Geosciences (GEO)", "Petrology and Geochemistry" ], "program_reference_codes": [], "program_officials": [ { "id": 3493, "first_name": "Eva", "last_name": "Zanzerkia", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2021-08-01", "end_date": null, "award_amount": 186556, "principal_investigator": { "id": 31046, "first_name": "Cailey", "last_name": "Condit", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Subduction zones – places where one tectonic plate sinks beneath another – are responsible for the generation of deadly earthquakes, explosive volcanoes, global chemical cycling into the deep earth, and tectonic plate movements. The thermal structure of a subduction zone (i.e., the temperature of different parts of the subduction zone at depth) exerts a first order control on the strength and mechanics of an individual subduction zone and also on what materials and volatiles (e.g., water) are transported down to the deep earth within subducting plates. Together, these temperature-dependent mechanical and chemical processes dictate the occurrence of subduction zone hazards such as earthquakes and volcanism. Thus, a longstanding goal of subduction research is a quantitative understanding of subduction zone thermal structure. Because these zones are 100s of km thick and 1000s of km long, we cannot directly measure their thermal structure. However, we can create detailed numerical simulations (subduction models) that predict thermal structure and allow us to investigate how it evolves and influences these mechanical and chemical processes. These models are guided by a broad range of tectonic observables in active subduction zones and by studies of subducted rocks that have been exhumed back to the surface. These data illuminate a range of thermal, chemical (petrological), and mechanical (rheological) feedbacks that operate over the lifetime of a subduction zone but are typically omitted from thermal subduction zone models. For instance, chemical reactions (e.g., metamorphism) in subducting plates are not only highly-temperature dependent, but also likely to affect the thermal structure of subduction zones. This is because different metamorphic rocks have different strengths and densities which, in turn, affect the subduction properties (convergence velocity between the two plates, dip angle of the subducting plate) that ultimately control subduction zone temperature. Motivated by these dynamic interactions, we will develop a suite of subduction models that directly incorporate these thermal-chemical-mechanical feedbacks. This modeling approach will allow us to probe how, and how rapidly, subduction zone thermal structure evolves, and also to characterize how this thermal variability impacts plate boundary strength and chemical cycling in these important tectonic zones. In addition to supporting undergraduate, graduate, and postdoctoral researchers, this project will also benefit society and the geoscience community through a combination of education, outreach, and scientific in-reach in the following ways: (1) we will develop an online lab activity for introductory geology classes to expose beginning geoscientists to computational methods, (2) we will host an in-reach subduction zone workshop at the University of Washington, and (3) we will reach out to the public by developing a digital exhibit on subduction zones at The Beneski Museum of Natural History (Amherst College).<br/><br/>To capture dynamic and time-evolving subduction behavior for Earth’s range of subduction settings, we will fully integrate geodynamic, petrologic, and rheological components into our modeling framework. Petrologic modeling will reveal the loci of slab devolatilization and density transformations through time. A suite of experimentally and geologically constrained rheologies will be used to calculate the time-evolving crustal viscosity structure. Both components will be fully integrated into the geodynamic modeling component (i.e., a time-dependent subduction model) so that calculated petrological phases, densities, and viscosities are dictated by, and also affect, the thermal evolution of the geodynamic model. After iteratively increasing the complexity of models (so as to preserve physical intuition as the number of model components grow), we will run models for parameter combinations corresponding to each subduction system on Earth. This will enable us place bounds on the properties of Earth’s slabs (temperature, dehydration systematics, density, viscosity), in space and time, and address three targeted questions relating to the co-evolution of slab thermal structure, dehydration, and mechanical properties: What evolutionary phase of subduction is associated with the most water transport to the deep mantle? What is the mechanical control on the so-called “decoupling depth” at subduction zones? And, lastly, what is the dominant control on the bi-modal timing of subducted rock exhumation?<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14625", "attributes": { "award_id": "1UG3CA290286-01", "title": "Self-Testing for Cervical Cancer in Priority Populations: the STEP-2 Trial", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 25565, "first_name": "VERONICA", "last_name": "CHOLLETTE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-05-15", "end_date": "2026-04-30", "award_amount": 705051, "principal_investigator": { "id": 31313, "first_name": "Amanda F.", "last_name": "Petrik", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 24997, "first_name": "Jasmin Anita", "last_name": "Tiro", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 31314, "first_name": "RACHEL L.", "last_name": "WINER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The 29.3 million patients receiving care in US Federally Qualified Health Centers (FQHCs) have much lower cervical cancer screening rates than national averages: Only 53% of eligible patients were up-to-date in 2021 and the COVID-19 pandemic exacerbated these disparities. Self-sampling for human papillomavirus (HPV) is an evidence-based cervical cancer screening method with high potential to reduce screening barriers. Self- sampling kits can be distributed at clinics or mailed to patients' homes. Despite widespread international adoption, HPV self-sampling is nascent in the US. Little data is available to inform implementing this preventive service in low-resource settings such as FQHCs. Our two-phase pilot and pragmatic trial will adapt and evaluate two programs to integrate HPV self-sampling into FQHCs. Our trial accounts for the context, capacity and resources of FQHCs, and leverages FQHC-Medicaid partnerships to promote this preventive care service. Phase 1 will be a milestone-driven planning phase. We will use community-based participatory research and stakeholder input to adapt and pilot-test 2 multilevel interventions in 2 FQHCs for distributing HPV self- sampling kits: in clinics and in clinics plus direct mailing. Phase 2 will be a cluster-randomized pragmatic trial in 42 Oregon and Washington FQHC clinics to evaluate the comparative effectiveness and cost-effectiveness of the interventions. Clinics will be randomized to Usual Care (UC), in-clinic distribution (Clinic Only), or in-clinic plus mailed distribution (Clinic + Mail). For in-clinic distribution, providers will offer self-sampling at in-person or telehealth encounters. The mailed component will be administered by Medicaid health plans. The primary outcome is the proportion of eligible patients (30-64 years, due/overdue for routine screening) who complete screening. Co-primary comparisons are (1) UC vs Clinic Only and (2) Clinic Only vs Clinic + Mail. To minimize bias, each comparison includes distinct but overlapping patient populations. Comparison 1 includes all patients (Medicaid and non-Medicaid) with a clinic encounter during the 12-month study period. Comparison 2 is restricted to Medicaid patients who are enrolled with the clinic, but does not require a clinic encounter during the 12-month study period. Cost-effectiveness will compare the Clinic Only HPV self-sampling intervention relative to UC, and Clinic + Mail relative to Clinic Only. We will use the RE-AIM framework and PRISM to assess provider, clinic and health plan acceptability and evaluate adaptations to the implementation strategies through mixed methods. Our pragmatic trial will be the first in the US to determine the effectiveness and cost- effectiveness of HPV self-sampling for increasing cervical cancer screening in FQHC settings. Results from our comparisons and evaluation of implementation strategies will inform broad-scale implementation of HPV self- sampling across FQHCs and other safety-net clinics in the US to reduce cervical cancer screening disparities.", "keywords": [ "Adherence", "Adopted", "Adoption", "COVID-19 pandemic", "Caring", "Cervical Cancer Screening", "Characteristics", "Clinic", "Clinical", "Cost Analysis", "Data", "Diagnosis", "Disparity", "Effectiveness of Interventions", "Eligibility Determination", "Enrollment", "Federally Qualified Health Center", "France", "Health Resources", "Healthcare Systems", "Home", "Human Papillomavirus", "Hybrids", "Individual", "Instruction", "International", "Intervention", "Maintenance", "Malignant neoplasm of cervix uteri", "Medicaid", "Methods", "Oregon", "Patients", "Persons", "Phase", "Population", "Preventive care", "Preventive service", "Protocols documentation", "Provider", "Randomized", "Reach Effectiveness Adoption Implementation and Maintenance", "Recommendation", "Recording of previous events", "Resource-limited setting", "Resources", "Sampling", "Speed", "Testing", "Underinsured", "Uninsured", "Visit", "Vulnerable Populations", "Washington", "arm", "cancer health disparity", "care systems", "clinical practice", "community based participatory research", "comparative effectiveness", "compare effectiveness", "cost effectiveness", "design", "effectiveness evaluation", "ethnic minority", "evidence base", "experience", "flexibility", "follow-up", "health care settings", "health plan", "implementation efforts", "implementation evaluation", "implementation strategy", "minority disparity", "participant enrollment", "patient oriented", "patient population", "pilot test", "pilot trial", "pragmatic randomized trial", "pragmatic trial", "primary outcome", "programs", "racial minority", "routine screening", "safety net", "screening", "screening disparities", "self testing", "sociodemographics", "telehealth", "treatment as usual" ], "approved": true } }, { "type": "Grant", "id": "14724", "attributes": { "award_id": "1R34AT012679-01", "title": "Pain Relief with Integrative Medicine (PRIMEe)?: Feasibility Trial of Acupuncture for Long COVID", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Complementary and Integrative Health (NCCIH)" ], "program_reference_codes": [], "program_officials": [ { "id": 23342, "first_name": "Beda", "last_name": "Jean-Francois", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-02-26", "end_date": "2027-01-31", "award_amount": 656157, "principal_investigator": { "id": 28200, "first_name": "Nikki", "last_name": "Gentile", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Post-acute sequelae of COVID-19 (PASC), or “Long-COVID” has negatively impacted millions of individuals with regard to quality of life, daily functioning, and ability to work, and has placed enormous demands on the healthcare system. Pain-related symptoms are reported by almost half of all patients with PASC, and yet pain is still not consistently addressed in work-ups or treatment options. Thus, we have chosen to study acupuncture for improving pain, quality of life, and function in individuals experiencing PASC-related pain. These treatments have been successful in treating various types of chronic pain and should lend themselves to similar results with PASC-related pain. Furthermore, acupuncture focuses on treating the whole patient, which makes it uniquely well-suited for a complex condition like PASC that affects multiple body systems. We propose an initial study to determine the feasibility of successfully conducting a subsequent fully-powered pragmatic randomized trial evaluating the effectiveness of Traditional Chinese Medicine acupuncture for persistent pain problems experienced by persons with PASC. Acupuncture is a physical treatment that aims to correct imbalances in the body (including inflammation and pain) within a Chinese Medicine paradigm. This study will occur through the University of Washington Post-COVID Rehabilitation and Recovery Clinic at the Northgate Primary Care Clinic site. Our specific aims are to (1) assess the feasibility of conducting a randomized clinical trial comparing acupuncture with usual care alone for reducing pain in patients with PASC; (2) evaluate the overall patient experience with participation in the feasibility trial and solicit suggestions about how the study procedures, documents, and treatment protocols could be improved to facilitate participation and better meet participants’ needs; and (3) revise study procedures, protocols, and instruments to prepare for a fully-powered pragmatic randomized trial. Our study is innovative because it focuses on treatments that address whole person health rather than individual symptoms. We believe whole-person-oriented treatments can improve outcomes for patients with PASC when used as adjuncts to usual medical care. This study has the potential to help patients with PASC improve function and quality of life, and to provide PASC clinicians with more tools to effectively respond to their patients’ needs.", "keywords": [ "Acupuncture Therapy", "Address", "Adherence", "Affect", "Area", "Body System", "COVID-19 impact", "Caring", "Chinese Traditional Medicine", "Clinic", "Clinical Trials", "Communication", "Complex", "Effectiveness", "Exclusion", "Feasibility Studies", "Foundations", "Healthcare Systems", "Individual", "Infection", "Inflammation", "Integrative Medicine", "Intervention", "Interview", "Language", "Learning", "Long COVID", "Manuals", "Medical", "National Center for Complementary and Integrative Health", "Pain", "Participant", "Patient-Focused Outcomes", "Patients", "Persistent pain", "Persons", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Procedures", "Protocols documentation", "Quality of life", "Questionnaires", "Randomized", "Recovery", "Rehabilitation therapy", "Reporting", "Research", "SARS-CoV-2 infection", "Sample Size", "Site", "Specific qualifier value", "Suggestion", "Symptoms", "Treatment Protocols", "Universities", "Washington", "Work", "arm", "care seeking", "chronic pain", "common symptom", "daily functioning", "debilitating symptom", "early phase clinical trial", "effective therapy", "effectiveness evaluation", "experience", "feasibility trial", "follow-up", "functional improvement", "improved", "improved outcome", "innovation", "instrument", "mind/body", "operation", "pain reduction", "pain relief", "participant retention", "pilot test", "post-COVID-19", "pragmatic randomized trial", "primary care clinic", "randomized clinical trials", "recruit", "response", "success", "tool", "treatment arm", "treatment as usual", "treatment strategy", "trial comparing", "whole health" ], "approved": true } }, { "type": "Grant", "id": "14863", "attributes": { "award_id": "1T32GM153182-01", "title": "University of Washington Medical Scientist Training Program", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 31549, "first_name": "Andrea", "last_name": "Keane-Myers", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-01", "end_date": "2029-06-30", "award_amount": 1798078, "principal_investigator": { "id": 31550, "first_name": "MARSHALL S.", "last_name": "HORWITZ", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The University of Washington (UW) Medical Scientist Training Program (MSTP) was established in 1970 and is the only MD-PhD program in the five “WWAMI” states (Washington, Wyoming, Alaska, Montana, and Idaho) comprising a quarter of the landmass of the United States. Our program has thus far produced 285 graduates, 78% of whom have been employed in scientific research throughout their careers. Our goal is to leverage institutional and national resources to build an educational pipeline leading to the development and identification of a diverse group of talented trainees and equip them with the skills, mentorship, role models, and motivation required to advance the frontiers of biomedical science and technology. Among multiple accomplishments, students and graduates of our program created the Apple Macintosh computer and one of the first enzyme replacement therapies for metabolic disease, have provided fundamental insights into the nature of stem cells, the sequence and structure of the human genome, and the infectivity of SARS-CoV-2, and have led similarly successful MD-PhD programs elsewhere, thereby exponentially amplifying our program’s impact on training the next generation of physician-scientists. Our competitive program has grown to an annual class of 15, comprising approximately one-fifth of all medical students in Seattle. For each offer of admission, we receive over 23 training- grant-eligible applications. Of our 96 current trainees, 21% are from populations under-represented in medicine and 19% are from disadvantaged backgrounds. Our partnership with Morehouse School of Medicine enriches both institutions. Our trainees carry out their PhD research with UW faculty mentors at the UW, Fred Hutchinson Cancer Research Center (Hutch), Seattle Children's Hospital Research Institute, and Benaroya Research Institute. Current trainees' PhD departments and programs include Molecular and Cellular Biology, Neuroscience, Genome Sciences, Bioengineering, Computer Science, Molecular Engineering, Chemistry, and Epidemiology. They are mentored by a highly trained group of 81 well-funded, diverse, and gender-balanced distinguished faculty drawn from across ranks of junior to senior investigators, who emphasize and practice responsible, reproducible science in safe training environments. Our program integrates medical and graduate education, while reducing redundancy. Mean time to completion is 8.3 years and on a shortening trajectory, with minimal attrition of 2.6%. Over half of trainees receive NIH F30 independent fellowships. Over the last 15 years, graduates published a mean of 6.7 peer-reviewed papers, including 2.8 as first-authors, many of which are exceptionally impactful and have altered the course of research in their fields. Nearly all graduates go on to research-related residencies at leading institutions, predominantly in fields conducive to long-term retention in research. We continually evaluate our outcomes, measure our progress toward its overarching objective of producing resilient physician-scientists pushing the envelope at the interface of science and medicine, and iteratively evolve our program to stay at the forefront of evidence-based innovations in training practices.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14874", "attributes": { "award_id": "1R01AI180936-01A1", "title": "Point-of-care Nucleic Acid Amplification Test for pangenomic Hepatitis C diagnosis in outpatient clinics", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 27983, "first_name": "JULIE", "last_name": "Dyall", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-03", "end_date": "2029-05-31", "award_amount": 706538, "principal_investigator": { "id": 24915, "first_name": "Jonathan D.", "last_name": "Posner", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Hepatitis C virus (HCV) infection is a widely prevalent bloodborne infection, with approximately 71 million global (2.4 million in USA) chronic infections worldwide. HCV infection is frequently asymptomatic and many of those infected are unaware of their illness. Untreated HCV infection may lead to chronic liver disease, such as hepatocellular carcinoma, and accounts for an estimated 1.1 million annual global deaths (14,000 USA). Within the last six years, direct acting antivirals (DAAs) have demonstrated high cure rates (90-95%) across all genotypes in less than 12 weeks of all-oral treatment. These highly effective therapeutics offer a path toward ending the HCV epidemic as drugs become more affordable and global health efforts prioritize expanded access. The rollout of DAAs relies on diagnostic testing to identify HCV cases and rapidly link eligible patients to treatment options. In most clinical settings, current HCV testing protocols use a rapid antibody test to diagnose past or current cases of HCV. While rapid HCV antibody tests are easy to use and widely available, current HCV nucleic acid amplification tests (NAATs) require venipuncture blood samples and central laboratories where tests are run by trained technicians on complex, expensive equipment, causing delayed test results and loss to follow-up. Recent initiatives by the Whitehouse White House’s HCV Elimination Program, WHO, MSF Access Campaign, and NIH (NOSI: NOT-AI-23-001) have encouraged the development of point-of-care (POC) HCV NAATs to provide accessible and rapid diagnosis of chronic HCV and aid in the rollout of DAAs. Decentralized, clinic-based HCV NAATs offer a streamlined approach to patient care where a single test may be used to diagnose HCV, identify active viremia, and later confirm a cure. There is an abundance of commercial POC NAAT tests for respiratory diseases, such as influenza or SARS-COV-2, but due to the significant technical challenges of detecting low viral titers in blood samples, there are no available capillary whole blood rapid POC NAATs for HCV that meet target product profiles. We have developed a new approach for an integrated POC NAAT for detecting HCV from whole blood. Our proposed HCV test is a significant departure from most existing POC tests that use classical extraction methods (solid phase extraction), multiple buffer exchanges, reaction chambers, PCR amplification, and robotics for physical actuation to automate and miniaturize laboratory-based PCR workflows. Here, we propose an innovative paper-based device with novel whole blood sample preparation and electrophoretically-mediated RNA purification, amplification, that is capable of simultaneously extracting and amplifying viral HCV RNA from whole capillary blood using reverse transcription recombinase polymerase amplification. The test cartridge consists of a paper and plastic device with no moving parts and provides results in less than 30 minutes. This low complexity diagnostic test is intended to be CLIA-waived and uses a disposable cartridge model with costs less than $5 and a benchtop reader costing less than $500, enabling expanded use in resource-limited clinics.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "14888", "attributes": { "award_id": "1T32GM153507-01", "title": "Molecular Biophysics Training Program", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 23650, "first_name": "Paula F.", "last_name": "Flicker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-01", "end_date": "2029-06-30", "award_amount": 659231, "principal_investigator": { "id": 31579, "first_name": "Justin M", "last_name": "Kollman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31580, "first_name": "NING", "last_name": "ZHENG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The University of Washington (UW) Molecular Biophysics Training Program (MBTP) is designed to train predoctoral students to apply state-of-art physical and quantitative approaches to the investigation of biomedically relevant systems at molecular and cellular levels. As manifested by the COVID-19 pandemic crisis, basic and translational research in almost all biomedical areas necessitate the adoption and implementation of rigorous and quantitative biophysical methods to dissect the fundamental mechanisms of molecular and cellular biology and to develop effective therapeutics against a variety of existing and emerging human diseases. This requirement calls for a highly trained workforce proficient in research methods at the intersection of physics, chemistry, engineering, and biology. The overarching objective of MBTP is to meet these needs by enhancing the research experience and training of holistically selected UW predoctoral students interested in molecular biophysics and preparing them for a productive career in health-related research in academia, government, and the private sector. Each year MBTP trainees are chosen through a rigorous selection process that identifies promising graduate students from a large pool of talented and diverse applicants admitted to UW through five interdisciplinary programs and nine departmental programs. During their graduate career, 10-12 MBTP trainees are provided with at least two years of mandatory structured activities to expose them to a wide range of biophysical methods, techniques, and research topics that go beyond their home graduate program. These training activities include, but are not limited to, a structural biology and biophysics graduate level course, a bi-weekly student research presentation series, a peer-organized student journal club and discussion group, an annual retreat trainee-centered retreat, and interactions with a larger local biophysics community. These activities are further supplemented with lectures and courses required or supported by MBTP and related UW departments. MBTP plays a special role at UW by actively nucleating a cross- departmental biophysics community. It fosters close interactions among trainees and their peer pre- doctoral students, who share common interests in molecular biophysics, but are otherwise separated by departments and graduate programs. By taking advantage of a growing body of UW faculty with biophysics background, MBTP creates a unique platform, where trainees learn about modern biophysical techniques, sharpen their communication skills, build and extend their professional network, establish and enhance their science identity and self-efficacy. The training program has a strong record of success and impact as evidenced by the diverse research-related career choices trainees make after they leave graduate school.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15001", "attributes": { "award_id": "5R01AI177512-02", "title": "Development of an Oral Pan-Coronavirus Drug Cocktail", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6115, "first_name": "DIPANWITA", "last_name": "Basu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-07", "end_date": "2028-06-30", "award_amount": 674611, "principal_investigator": { "id": 23030, "first_name": "STEPHEN J.", "last_name": "POLYAK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 23243, "first_name": "Joshua Tisdell", "last_name": "Schiffer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 757, "ror": "", "name": "FRED HUTCHINSON CANCER RESEARCH CENTER", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "This R01 comprises a collaboration between scientists in the US and Belgium that seeks to develop synergistic antiviral drug combinations that keep pace with the evolution of the SARS-CoV-2/COVID-19 pandemic and future outbreaks of related coronaviruses. We will exploit i) the principles of synergistic activity that arise with drug combinations and ii) novel mathematical approaches to optimize human dosing for treating emerging and re-emerging coronaviruses with pandemic potential. We will identify combinations of drugs that i) target conserved cellular factors that support virus infection, and/or ii) target viral enzymes that are essential for viral replication, to develop novel antiviral drug combinations against multiple coronaviruses (i.e., a pan-family drug cocktail). Based on our previous work, mathematical modeling approaches will be used to i) identify drug combinations with synergistic antiviral action, ii) prioritize drug combinations and dosing strategies for testing in rodent models of virus infection and disease, and iii) predict in vivo efficacy in humans with various dosing strategies. Our research plan provides a proactive approach for global pandemic response and preparedness, with deliverables consisting of i) combinations of compounds that confer potent, synergistic suppression of multiple coronaviruses and have sufficiently high and durable plasma and tissue concentrations and ii) publicly available harmonized clinical trial designs that will allow for efficient testing of multiple agents in parallel at the inception of new epidemics. As the approach is applicable to any virus family, the project portends global impact by improving protection of the general population against existing viral threats, enhancing preparedness and response for future viral outbreaks, and offering immediately testable and deployable oral drug combinations that fill the time void between virus identification and development and deployment of viral sequence-specific vaccines, antibodies, and drugs.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15024", "attributes": { "award_id": "5F31DA059186-02", "title": "Isolating the role of endogenous mu-opioid activity in the VTA during natural reward", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 27803, "first_name": "Beth", "last_name": "Babecki", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-07-01", "end_date": "2026-06-30", "award_amount": 48974, "principal_investigator": { "id": 27804, "first_name": "Catalina Alejandra", "last_name": "Zamorano", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "SUMMARY: Opioid use disorder and opioid overdose death rates in the United States reached unprecedented levels during the COVID-19 pandemic. Understanding how endogenous opioid activity affects natural reward seeking is crucial to understanding the neuropharmacological basis of opioid use disorder. Previous research implicates the mesolimbic dopamine pathway, which refers to dopamine neurons projecting from the Ventral Tegmental Area (VTA) to the Nucleus Accumbens (NAc), in reward and addiction. Recent studies show that gamma-aminobutyric acid (GABA) containing neurons in the VTA (VTAGABA) provide local inhibition of dopamine neurons that synapse onto the NAc, thus playing a role in regulating reward behaviors. Importantly, these VTAGABA neurons contain a variety of G-protein coupled receptors, specifically the µ-opioid receptor (MOR). However, the exact role of these receptors and their signaling play in VTAGABA neurons and consequent regulation of natural reward is unknown. The source of endogenous opioid neuropeptide onto these MORs, and how these impacts signaling and activity has not been described. The central hypothesis of this proposal is that µ-opioid receptor signaling on VTAGABA neurons is regulated by afferent endogenous opioid peptides, resulting in disinhibition of VTAGABA neuron excitability. This results in control of dopamine neuron activity, and ultimately the expression of natural reward-seeking. This proposal directly addresses NIDA's Priority Scientific Area 1 that aims to further understand the molecular, neuropharmacological and circuit changes induced by drug use. Aim 1 will isolate the role of endogenous µ-opioid peptides in the VTA on dopamine signaling and natural reward- seeking. Aim1A uses ex vivo two-photon imaging and neuropharmacology approaches to visualize VTAGABA and VTA DA dynamics. Aim1B will investigate the effects of MOR ablation in the VTA on dopamine activity and behavior. Aim 2 will isolate the source and dynamics of endogenous µ-opioids in the VTA during natural reward behavior. In Aim 2A, I will use viral tracing techniques to anatomically visualize inputs from the lateral hypothalamus (LH) to the VTA. Aim 2B will test the effects of endogenous µ-opioid signaling on VTAGABA and DA activity in the NAc during reward seeking behaviors. In Aim 2C, I will use molecular approaches including CRISPR gene-editing and a recently developed µ-opioid biosensor (µMASS1) to understand the spatiotemporal aspects of MOR signaling in VTAGABA neurons during reward seeking. This career development training and series of experiments will provide insight into the role of endogenous MOR signaling on dopaminergic activity and natural reward-seeking. For this proposal, I will train in slice electrophysiology, two-photon slice imaging, gene-editing, molecular neuropharmacology, and behavioral approaches to understand how specific neuropeptides regulate reward circuits. This F31 proposal will greatly advance my career development plan and prepare me for a career as an independent, academic neuropharmacologist.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15052", "attributes": { "award_id": "5R01HD111433-02", "title": "Delivering Evidence-Based Parenting Services to Families in Child Welfare Using Telehealth", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 7137, "first_name": "LAYLA E", "last_name": "ESPOSITO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-06-15", "end_date": "2028-05-31", "award_amount": 661957, "principal_investigator": { "id": 27647, "first_name": "MONICA L", "last_name": "OXFORD", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The severe acute respiratory syndrome coronavirus 2 (denoted COVID-19) pandemic has shaken the foundation of services delivered to vulnerable families involved with or monitored by the child protective/welfare system. COVID-19 has changed the landscape of how children and families interact with the vital services provided by the child welfare system. Home visitation, which includes a bedrock of essential and transformative parenting support services for families involved with child welfare, was no longer safe or viable in the presence of COVID-19. The pandemic shredded safety nets. It made evident to providers, administrators, and policymakers how fragile our child protective system is. Under this strained state, child welfare agencies and mental health providers innovated service delivery systems. In Washington State, the Department of Children, Youth, and Families (DCYF) worked with local service agencies providing evidence-based programs to revise program protocols. Provider teams and program developers worked together to transition in-person services to remote platforms by developing and delivering telehealth services to families. The pandemic created the conditions for a natural experiment in service delivery in Washington State. The natural experiment proved that telehealth services are a viable service delivery system; thousands of child welfare involved families were served via telehealth. We do not know, however, if these services were effective, or which families had the technological capacity to engage, or for those who did engage were they able to complete the program. Did online home visiting produce the expected outcomes? While online delivery was an innovation driven by the necessity in response to COVID-19, many questions remain. The potential is high, but little is known about telehealth in child welfare. This proposal is a three-arm effectiveness trail of an evidence-based home visiting program: 1) delivered online, 2) delivered in-person, and 3) usual care. We will assess the effectiveness of Promoting First Relationships (PFR: a 10-week model) to improve observed parent-child interaction and caregivers’ knowledge of social and emotional development in a sample of 358 caregivers with children under age 18 months at enrollment. We will also assess if PFR reduces child externalizing behavior and reduces out of home placements of the child into foster care. We will assess the cost-effectiveness of providing PFR via telehealth. We will address the degree to which families in Child Protective Services (CPS) have the technology needed to engage with telehealth services, as well as family satisfaction and compliance. Finally, we will measure service providers’ fidelity to the PFR model and their adherence to delivering PFR via telehealth. The proposed study leverages a longstanding partnership between the University of Washington and Washington State DCYF, overseeing services in child welfare to answer these questions.", "keywords": [ "2019-nCoV", "Address", "Adherence", "Administrator", "Age", "Attention", "COVID-19", "COVID-19 pandemic", "Caregivers", "Caring", "Child", "Child Care", "Child Rearing", "Child Welfare", "Communities", "Control Groups", "Cost Analysis", "Cost-Benefit Analysis", "Data", "Development", "Drops", "Economics", "Effectiveness", "Eligibility Determination", "Emotional", "Enrollment", "Evidence based program", "Failure", "Family", "Foundations", "Funding", "Health Personnel", "Health Services", "Health Services Accessibility", "Home", "Home visitation", "Household", "Interruption", "Investigation", "Knowledge", "Learning", "Measures", "Mental Health", "Methodology", "Modeling", "Monitor", "Natural experiment", "Noise", "Occupations", "Outcome", "Parent-Child Relations", "Parents", "Persons", "Policy Maker", "Procedures", "Protocols documentation", "Provider", "Randomized Controlled Trials", "Reporting", "Risk", "Sampling", "Schools", "Service delivery model", "Services", "Social Change", "Source", "System", "Technology", "Time", "United States", "Universities", "Washington", "Work", "Youth", "arm", "care systems", "child protective service", "cost effective", "cost effectiveness", "design", "distraction", "dosage", "effectiveness evaluation", "effectiveness testing", "evidence base", "externalizing behavior", "family support", "foster care", "improved", "innovation", "maltreatment", "member", "online delivery", "pandemic disease", "prevention service", "programs", "provider adherence", "randomized controlled design", "response", "safety net", "satisfaction", "school closure", "service delivery", "service providers", "service utilization", "social", "social service provider", "telehealth", "treatment as usual", "welfare", "wireless fidelity" ], "approved": true } }, { "type": "Grant", "id": "15091", "attributes": { "award_id": "2346335", "title": "Collaborative Research: CIRC: New: Facilitating Language Technologies for Crisis Preparedness and Response", "funder": { "id": 3, "ror": "https://ror.org/021nxhr62", "name": "National Science Foundation", "approved": true }, "funder_divisions": [ "Computer and Information Science and Engineering (CISE)", "CCRI-CISE Cmnty Rsrch Infrstrc" ], "program_reference_codes": [], "program_officials": [ { "id": 31622, "first_name": "Cindy", "last_name": "Bethel", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-10-01", "end_date": null, "award_amount": 584184, "principal_investigator": { "id": 31628, "first_name": "Fei", "last_name": "Xia", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31627, "first_name": "William D", "last_name": "Lewis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Language technologies are promising and could have strong impact during disaster responses. they can help to triage text messages in a disaster to determine what aid to provide. Language technologies can translate vast amounts of data related to an ongoing pandemic. Responders can use these technologies to converse with victims during disaster responses. However, advances in language technologies to date are limited. They focus on a few dozen of the more than 6500 languages spoken or signed in the world today. Current language technologies neglect millions of people. This especially impacts those who are most at risk for experiencing disasters. This project provides an infrastructure for language technology advancements for crisis response. The results will be useful for everyone, no matter the language they speak.<br/><br/>This project builds datasets of crisis communications using dedicated data collections and social media harvesting. These datasets will be applicable to curated crisis scenarios. They will use common language scenarios necessary to communicate with vulnerable populations. This approach helps people for whom language technologies are not typically developed. The project will bring together researchers from different disciplines. These include language technology researchers, experts in disaster relief, linguistics, and human-computer interaction. The project will target representatives from the local speech communities to take part. To coordinate this effort, the project will organize yearly workshops and shared tasks with the communities.<br/><br/>This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1384, "pages": 1442, "count": 14420 } } }