Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=principal_investigator
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=principal_investigator", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1405&sort=principal_investigator", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=principal_investigator", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=principal_investigator" }, "data": [ { "type": "Grant", "id": "15374", "attributes": { "award_id": "1R21AG089374-01", "title": "Impact of SARS-Cov-2 on a Rat Model Cerebral Amyloid Angiopathy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 26177, "first_name": "Maja", "last_name": "Maric", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-15", "end_date": "2026-05-31", "award_amount": 196875, "principal_investigator": { "id": 31975, "first_name": "William E.", "last_name": "Van Nostrand", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 161, "ror": "https://ror.org/013ckk937", "name": "University of Rhode Island", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "Although the pandemic phase of SARS-CoV-2 infections has diminished the disease remains highly endemic in the US population with current weekly hospitalizations from infection remaining in the thousands and significant morbidity. Further, there is always the risk that new SARS-CoV-2 variants may arise that are more transmissible and/or pathogenic. Therefore, SARS-CoV-2 infections will remain a significant health issue in the US for the foreseeable future. Although SARS-CoV-2 infection is largely viewed as a respiratory disease there is substantial evidence that SARS-2-CoV-2 infection is a “vascular disease” caused by endothelial cell uptake of the virus via angiotensin converting enzyme 2 (ACE2) that can affect various organs including the brain. With regards to the cerebral vasculature, SARS-CoV-2 infection can cause coagulopathy and local thrombotic events in the brain including ischemic and hemorrhagic stroke. How other cerebral vascular diseases interact with SARS-CoV-2 infections is poorly understood. Cerebral amyloid angiopathy (CAA) is a common amyloidal form of cerebral small vessel disease of the elderly that is characterized by the accumulation of fibrillar amyloid b-protein (Ab) in blood vessels of the brain. CAA is also a frequent vascular comorbidity in patients with Alzheimer’s disease and related disorders (ADRD). Cerebral vascular accumulation of Aβ can result in perivascular neuroinflammation, cerebral infarction, microbleeds and intracerebral hemorrhages. Because of these cerebral vascular insults, CAA is a significant cause of vascular-mediated cognitive impairment and dementia (VCID). Recently, we generated a novel transgenic rat model for CAA, designated rTg-D, that recapitulates many of the pathological features of the disease in humans including cortical and meningeal vascular amyloid, cerebral microbleeds, small vessel occlusions, and VCID. The rTg-D rat model provides a useful platform for investigating the pathogenesis of CAA and the impact of comorbidities. There are reports in the literature indicating that SARS-CoV-2 infection can impact CAA in a highly detrimental manner promoting hemorrhagic events. Yet despite this link the effects of SARS-CoV-2 infection on the course of pathology of CAA and other ADRDs remains largely unknown. Thus, the goal of this R21 exploratory proposal is to investigate the impact of SARS-CoV-2 infection on the emergence, progression and severity of CAA in the novel rTg-D transgenic rat model of CAA. To accomplish this goal, we propose two specific aims. First, we will determine if the SARS-CoV-2 spike 1 protein accelerates the emergence and progression CAA and associated pathologies in younger rTg-D rats. Second, we will determine if the SARS-CoV-2 spike 1 protein exacerbates CAA associated vasculopathies in aged rTg-D rats. Our studies will combine quantitative pathological measures and transcriptomic approaches in a novel preclinical model of CAA to identify key elements of activation pathways that are shared between CAA and SARS-CoV-2 infection.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15375", "attributes": { "award_id": "1R15GM157661-01", "title": "Molecular Mechanism of Folding of Nsp12 and Assembly of the SARS-CoV-2 RNA Polymerase Complex by the Cytosolic Chaperonin CCT", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 24785, "first_name": "ANDRE W.", "last_name": "PHILLIPS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-18", "end_date": "2027-08-31", "award_amount": 447548, "principal_investigator": { "id": 31976, "first_name": "BARRY M", "last_name": "WILLARDSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 436, "ror": "https://ror.org/047rhhm47", "name": "Brigham Young University", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic created the greatest infectious threat to global health in 100 years, and monumental efforts have been made by the scientific community to combat the SARS-CoV- 2 virus. This proposal seeks to extend this effort by investigating a mechanism by which SARS- CoV-2 hijacks the host cell chaperone system to replicate itself. We have evidence that the SARS-CoV-2 RNA polymerase (RdRp) co-opts the cytosolic chaperonin containing TCP-1 (CCT, also called TRiC) to assemble the active polymerase complex. CCT is a large (1 MDa) protein-folding machine that plays a major role in the cellular chaperone network responsible for maintaining the proteome in good working condition. It uses ATP hydrolysis-driven conformational changes to assist cytosolic proteins with multiple domains, complex folding trajectories, or obligate binding partners to achieve their native state and assemble into complexes. In addition to folding cellular proteins, CCT has been shown to bind several viral proteins and contribute to viral replication of HIV, hepatitis C, influenza A, rabies, Zika and reovirus. These observations show that CCT is a common host chaperone used by diverse viruses to fold viral proteins, assemble viral complexes, and support viral replication. Based on these findings, we initiated an investigation of the role of CCT in SARS-CoV-2 replication. Here, we present robust preliminary evidence indicating that the SARS-CoV-2 non-structural protein 12 (Nsp12), the catalytic subunit of the RNA polymerase, is folded by CCT and that CCT contributes to RdRp complex formation and SARS-CoV-2 replication. In Aim 1, we propose to thoroughly test this hypothesis using multiple experimental approaches. In Aim 2, we propose to determine high-resolution structures of the complex between Nsp12 and CCT. We have isolated an Nsp12 folding intermediate bound to CCT and have determined preliminary structures of the complex by cryogenic electron microscopy (cryo-EM). Further cryo-EM analysis will yield a high- resolution structure of the Nsp12-CCT complex, which will be invaluable in guiding the design of therapeutics to block Nsp12 folding by CCT, inhibit formation of the RdRp complex, and disrupt viral replication.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15376", "attributes": { "award_id": "1R43HL172484-01", "title": "A novel mobile phone technology to improve access for preeclampsia and hypertension detection", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 25676, "first_name": "JASMINA", "last_name": "Varagic", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-20", "end_date": "2025-08-31", "award_amount": 292897, "principal_investigator": { "id": 31977, "first_name": "John conrad", "last_name": "Heironimus", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28353, "first_name": "Martin Richard", "last_name": "Huecker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28354, "first_name": "David", "last_name": "Wolfson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2096, "ror": "", "name": "TELE-STETHOSCOPE INC.", "address": "", "city": "", "state": "KY", "zip": "", "country": "United States", "approved": true }, "abstract": "/ Abstract Preeclampsia is a complication affecting 2 – 8% of all pregnancies and results in significant maternal and neonatal morbidity and mortality. The invention to be researched in this grant detects preeclampsia and hypertension in patients with the phones that they already own. It improves outcomes by increasing access to care among underserved populations and monitoring frequency among high risk patients. Patients record themselves using their own phones which takes only a few minutes. The long term objective is to commercialize a product which enables any of 7 billion phones to assist in preeclampsia or gestational hypertension detection. The invention is intended to be used at home by patients via a phone app with results sent to the prescribing obstetrician (OB). The purpose is to alert the OB if immediate physical examination is needed and to initiate possible preeclampsia management protocol. In these situations, there are no other comparable testing options. The invention includes both improvements to clinical practice and to science. Current clinical practice standard of care requires patients to be examined in an OB office. The invention allows preeclampsia and hypertension to be detected via patient self-examination from locations outside the OB office. This improves upon current technology such as home blood pressure cuffs and in-office dipstick urinalysis. In terms of improvements to science, the invention consists of both a Universal Translator (UT) and Deductive Intelligence (DI). UT allows for any mobile phone to capture body acoustic data. DI is a novel physics based approach to creating classifier algorithms from passively received time series data, such as mobile phone recordings received from the UT. The invention analyzes hemodynamics and extracts pertinent physics based features from which a classifier algorithm is based. This will be the third large scale human study that demonstrates classification of cardio - pulmonary functionality. It follows a published study on COVID detection as well as a study under peer review on the ability to reproduce echocardiogram estimates of ejection fraction. The echocardiogram study establishes the protocol to be used in the proposed research. In a recent preliminary study, 46 pregnant women were recorded at the aortic site. The resulting model was able to determine which patients had high blood pressure and to accurately determine which patients had complications. These studies support our hypothesis that acoustic hemodynamic data captured by OEM phone microphones, at the aortic auscultation site and at the upper arm, can be used to identify patients who have preeclampsia and/or hypertension. The study has two primary aims. The first is to demonstrate proof of concept that the invention enables ordinary mobile phones to reproduce physicians’ diagnosis of pre-eclampsia. The second aim is to demonstrate proof of concept that the invention enables ordinary mobile phones to reproduce cuff measurements of blood pressure and to detect hypertension. The approach is based on recruitment from both outpatient clinics and inpatient hospital settings. Patients already labeled with preeclampsia or high blood pressure will be enrolled as well as control patients without disease conditions. Patients will be recorded by clinicians with a custom phone app. Algorithms will be developed based on these recordings using UT and DI. Results will be tested and analyzed using AUC, sensitivity/specificity, accuracy as well adj RSQ for the linear regression analysis. The team consists of a broad range of talent including the inventor of the technology, the Maternal Fetal Medicine Division Director at the hospital, the research director of emergency medicine for the hospital running the tests, statistical expertise, and project management.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15377", "attributes": { "award_id": "1R01NR021461-01", "title": "Examining Non-Congregate Shelter Effects on Mental Health Crises through Community Health Partnerships in Connecticut", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 12184, "first_name": "Shalanda A", "last_name": "Bynum", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-11", "end_date": "2027-08-31", "award_amount": 2432517, "principal_investigator": { "id": 31978, "first_name": "ANNIE", "last_name": "HARPER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31979, "first_name": "Ambrose H", "last_name": "Wong", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 452, "ror": "https://ror.org/03v76x132", "name": "Yale University", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "People experiencing homelessness have a disproportionate burden of mental illness and mortality than those who are not homeless. The environment in congregate shelter accommodation may significantly contribute to this health burden, particularly regarding mental health. Housing insecurity significantly increases risk of presenting to the emergency department in behavioral crises, especially for individuals who are Black and Latinx as well as sexual and gender minorities. In response to public health concerns regarding the specific vulnerabilities of this population to COVID, many cities implemented programs diverting congregate shelter residents, most commonly to hotel accommodation. There is some evidence that the shift to non-congregate living may have had a positive impact on people's mental health. Connecticut localities are planning new policies designed to build on lessons learned from that period, providing non-congregate options through healthcare- community partnership organizations to people who are unhoused. Understanding the mental health effects of non-congregate shelter options is essential to inform these developing policy reforms and innovations. This project will use a Community Based Participatory Research transformative approach, with a multistage convergent parallel mixed methods design, to measure the impact of healthcare-housing community partnerships that support non-congregate living interventions on mental health. We will conduct the study in Connecticut, which received the most expansive eligibility standards in the nation and included diversion of the state's entire homeless population to hotel rooms. This context presents an unprecedented opportunity to study the relationship between shelter interventions and mental health outcomes. We will aim to study the impact of both the above-mentioned shelter policies and developing and ongoing post-pandemic housing initiatives on mental health crises by: 1) Qualitatively exploring mechanisms between non-congregate housing policies and mental illness including a landscape analysis to characterize processes through which shelter and healthcare providers partner to address housing needs, building on strong existing relationships with stakeholders and people experiencing homelessness; 2) Characterizing the effect of Connecticut's hotel-based temporary shelter program on mental health crises among patients experiencing homelessness who were diverted from congregate shelters to hotel rooms during the COVID-19 pandemic compared to a control site in Alabama using data from electronic medical records to perform a difference-in-differences identification strategy; and 3) Prospectively evaluating, using mixed methods, the impact of post-pandemic housing policies that offer non-congregate living options on mental health, including non-congregate spaces in existing shelters, and newer potential policies such as tiny house villages. Findings from this study have the potential to inform policies and procedures of healthcare- housing community partnerships and improve mental health among those experiencing homelessness.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15379", "attributes": { "award_id": "1R13FD008331-01", "title": "2024 FDA Retail Food Protection Seminar and Illinois Environmental Health Association’s Annual Education Conference", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [ { "id": 31980, "first_name": "Danielle", "last_name": "Head", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-30", "end_date": "2025-08-31", "award_amount": 50000, "principal_investigator": { "id": 31981, "first_name": "Anna Marie", "last_name": "Yates", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2538, "ror": "", "name": "ILLINOIS ENVIRONMENTAL HEALTH ASSOCIATION", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "FDA Support for Conferences and Scientific Meetings Funding Opportunity Announcement (FOA) Number: PAR-23-072 Participant: Illinois Environmental Health Association Program Dates: July 2024- December 2024 Project Summary Illinois Environmental Health Association is seeking funding from the FDA for the FDA Support for Conferences and Scientific Meetings Funding Opportnity. The funding will be used for the FDA/ IEHA Retail Food Seminar and Annual Education Conference in Chicago, Illinois. The Conference will be September 11-13, 2024 focusing on Food Safety. Our goal is to provide an opportunity for surrounding states to send their food program staff to a two and half day seminar where they will gain knowledge of food safety topics. Since the covid pandemic, it is pertinent that we continue providing opportunities for states to network and collaborate to keep up with the growing food integration. Our goal is to showcase the past, present, and future of public health through speakers and topics.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15382", "attributes": { "award_id": "1R03HL174682-01", "title": "Quantitative magnetic resonance imaging of pulmonaryperfusion", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 26329, "first_name": "SIDDHARTH KAUP", "last_name": "Shenoy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-15", "end_date": "2026-06-30", "award_amount": 122788, "principal_investigator": { "id": 31982, "first_name": "Iris Yuwen", "last_name": "Zhou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The goal of this project is to establish a pharmacokinetic model for absolute quantification of pulmonary perfusion and microvascular parameters and validate this model in large animal models with independent tissue analyses of perfusion, vascular permeability, and pathological features. Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with highly variable clinical courses and poorly understood pathogenic mechanisms. Accumulating evidence shows that abnormalities in the pulmonary endothelium set off a cascade of events that promote increased vascular permeability, fibroblast activation, and excessive extracellular matrix deposition, ultimately leading to the development of fibrotic lung tissue and impaired lung function. However, the changes in the pulmonary endothelium of the fibrotic lung have not been well defined. Dynamic contrast- enhanced MRI (DCE-MRI) is a powerful imaging technique whereby the kinetics of an intravenous contrast bolus such as the FDA-approved agent Gd-DOTA can be modeled for quantitative measurement of tissue perfusion and vascular permeability. Accurate assessment of these changes in IPF will provide an improved understanding of the pathophysiology of pulmonary fibrosis, which is valuable for improving patient care and facilitating drug development for this deadly disease. Previously, we demonstrated that DCE-MRI with model- free analysis allows for indirect but sensitive detection of alterations in perfusion, permeability, or extracellular extravascular volume in patients with IPF or prior COVID infection compared to healthy volunteers, thus providing in vivo regional functional information not otherwise available. However, the pathophysiological interpretation of these results remains to be elucidated because the model-free approach indirectly measures a collective effect of changes in perfusion and microvascular parameters. The standard pharmacokinetic model in common use for DCE-MRI, Tofts model, is oversimplified, assuming instantaneous intercompartmental water exchange and negligible blood volume which are not valid for the lung and thus propagates into significant systematic errors in physiological parameters extracted from DCE data. To overcome these challenges, I propose to extend the standard Tofts model to encompass intercompartmental water exchange rate and true compartmental fractions for DCE-MRI of the lung and validate the physiological measurements derived from this extended model with independent tissue analyses in a large animal model of IPF. The output of this project will be a robust analytical tool for absolute quantification of pulmonary perfusion and microvascular parameters in the lung, which will not only provide a quantitative understanding of the pathophysiologic mechanism underlying IPF and other pulmonary diseases but also be valuable for improving patient care and facilitating drug development for this deadly disease.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15383", "attributes": { "award_id": "1R01DA059457-01A1", "title": "A Growing Crisis of Novel Injection-Related Wounds and Skin & Soft Tissue Infections among People Who Inject Drugs: A Community-Based, Longitudinal Investigation in North Carolina", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 23652, "first_name": "MELISA RAY", "last_name": "Creamer", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-09-30", "end_date": "2028-08-31", "award_amount": 661013, "principal_investigator": { "id": 31983, "first_name": "Jon Eric", "last_name": "Zibbell", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 809, "ror": "", "name": "RESEARCH TRIANGLE INSTITUTE", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "We propose a community-based, longitudinal, mixed-methods study to investigate the growing crisis of injection-related wounds and skin and soft tissue infections (IWSSTIs) among people who inject drugs (PWID) in the United States. Lost among the data on skyrocketing overdose deaths is an alarming increase in the prevalence and severity of novel IWSSTIs. IWSSTIs are a leading cause of morbidity for PWID and the most common cause of hospitalizations. More than 100,000 IWSSTIs have occurred annually since 2018. When left untreated, IWSSTIs can become septic, gangrene, and progress to catastrophic infections that require complicated surgeries and long-term medical care. IWSSTIs can stress hospital systems already overburdened with COVID-19, consume limited Medicaid funding, and increase stigma toward PWID. While IWSSTIs have been a concern for PWID for decades, rising incidence of dermal reactions and antinociceptive effects from synthetic drugs and novel psychoactive substances (NPS) represents a new and emerging public health crisis. The Office of National Drug Control Policy recently listed xylazine as an emerging threat and the Centers for Disease Control and Prevention warned of xylazine’s growing involvement in fentanyl overdose deaths. Aim 1: To observe, examine, and typologize IWSSTIs by DSS factors through Consensus-based Clinical Case Reporting Guideline Development (CARE)26-informed case reports, ethnographic interviews, and community-based drug checking among a qualitative sample of 30 PWID (15/site) in western NC; Aim 2: To examine associations between DSS factors and IWSSTI risk among a longitudinal cohort of PWID in NC (N = 450). To achieve these aims, we will recruit PWID from SSPs, homeless encampments, motels, and other places where PWID reside and congregate at the two study sites and surrounding counties (see Facilities). Aim 1 will be accomplished using targeted sampling methods and Aim 2 will be accomplished using respondent-driven sampling (RDS). The study will be led by Principal Investigator Jon Zibbell, a National Institute on Drug Abuse (NIDA)–funded behavioral scientist with many years of experience studying injection drug use and infectious disease risk among PWID. The team also includes William Zule, a NIDA-funded epidemiologist; Arnie Aldridge, a National Institutes of Health–funded statistician; Asher Schranz, a physician and medical expert in injection-related infectious diseases; and Sarah Duhart Clarke, an applied psychologist. Findings from the proposed study will help characterize the etiology and unique features of IWSSTs by DSS factors and quantify xylazine prevalence in the illicit drug supply in western NC. Because growing xylazine contamination and sharp growth in novel IWSSTIs among PWID together comprise an emerging crisis, these data are time sensitive, and the proposed study is poised to make a timely and effective contribution to inform public health response.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15384", "attributes": { "award_id": "1F31HD114457-01A1", "title": "Early Puberty During the COVID-19 Pandemic in a Multi-Ethnic, Population-Based Cohort of Children and Adolescents", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 21091, "first_name": "KAREN", "last_name": "WINER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-01", "end_date": "2026-06-30", "award_amount": 46614, "principal_investigator": { "id": 31984, "first_name": "Julia", "last_name": "Acker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1079, "ror": "", "name": "UNIVERSITY OF CALIFORNIA BERKELEY", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Early puberty is associated with adverse health outcomes over the life course, including psychopathology in adolescence, and reproductive cancers, diabetes, and cardiovascular disease in adulthood. The age of pubertal onset has declined dramatically over the past 40 years in the United States (US), with alarming racial/ethnic disparities. These disparities may amplify future health inequities in chronic conditions, yet remain poorly understood. During the COVID-19 pandemic, pediatric endocrinology centers across twelve countries reported large increases in the incidence of central precocious puberty (CPP), a rare condition characterized by developing secondary sexual characteristics before age eight in girls and nine in boys. However, existing studies are subject to limitations such as small samples from specialty care settings, insufficient power to examine trends in boys, and reliance on diagnostic criteria for CPP. In addition to CPP, it is important to examine normative timing of early pubertal milestones, including onset of pubic hair and breasts/testes development, because they represent the earliest observable markers of underlying hormones and may play differential roles in the etiology of health outcomes. Moreover, no studies have investigated whether the pandemic exacerbated pre-existing racial/ethnic or neighborhood-level disparities in pubertal timing. To fill gaps in current knowledge, this study will leverage electronic health records from Kaiser Permanente Northern California (KPNC) to conduct the first population-based study on the pandemic and pubertal timing in the US. KPNC comprises ~32% of the northern California population and has 4.4 million members. In 2010, KPNC began systematically documenting routine pubertal development assessments for all children aged 6 years and older, thereby facilitating the study of trends in both CPP incidence and normative pubertal timing in a population with considerable racial/ethnic, socioeconomic, and geographic diversity. First, we will estimate pre–post pandemic changes in incident CPP diagnoses at KPNC medical centers using an interrupted time series design, using data from 2017–2023 (Aim 1). Second, we will use survival analysis techniques to estimate pre–post pandemic changes in the timing of normative pubertal milestones (including onset of pubic hair development, breast/testes development, and menses) in a representative population cohort of approximately 103,000 boys and 72,000 girls (Aim 2). Finally, we will examine the differential impact of the pandemic on CPP and normative pubertal timing across diverse racial/ethnic groups and neighborhood conditions (Aim 3). Study strengths and innovations include the use of a robust quasi-experimental design, longitudinal assessment of a large and representative population of boys and girls, and investigation of several important hallmarks of puberty. Examination of racial/ethnic and place-based disparities will guide the design of upstream health equity interventions and inform both clinical practice and future pandemic response. This study also provides a foundation for future research to determine whether earlier puberty has lasting health consequences for today’s children as they transition to adulthood.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15385", "attributes": { "award_id": "1K08AI181642-01A1", "title": "Cost-Effectiveness of HIV Testing in U.S. Emergency Departments", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 6828, "first_name": "Rosemary G", "last_name": "McKaig", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-19", "end_date": "2029-06-30", "award_amount": 192672, "principal_investigator": { "id": 31985, "first_name": "Christopher L", "last_name": "Bennett", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "/ ABSTRACT Roughly 1 in 8 Americans living with HIV are unaware of their infection. As an entry point into the healthcare system, emergency departments (EDs) are uniquely positioned to help reduce this burden of undiagnosed HIV in the U.S. A growing amount of all healthcare in the U.S. is delivered in an ED setting. Unfortunately, compared with other settings, EDs have some of the lowest HIV testing rates. These rates further declined leading up to the COVID-19 pandemic and despite renewed efforts in the Ending the HIV Epidemic in the U.S. (EHE) initiative. Decreasing testing rates appear to stem from several barriers, including concerns about cost and the impact of increased testing on overcrowding and boarding. Unfortunately, few studies have focused on exploring these barriers, either since EHE’s launch or following the COVID-19 pandemic. The primary purpose of this award is to provide Dr. Christopher Bennett, Assistant Professor of Emergency Medicine at Stanford University, the support necessary to facilitate their long-term goals to (1) help EDs lead the charge in ending the HIV epidemic in the U.S. and (2) transition from a junior investigator to an independent physician–scientist with expertise in economic analyses, implementation science, and qualitative methods. In Aim 1, Dr. Bennett will train in economic analyses to investigate the cost-effectiveness of ED-based HIV screening in geographic areas targeted by EHE compared against current screening rates and then determine the incremental cost-effectiveness of HIV screening in all U.S. EDs. In Aims 2 and 3, the candidate will innovatively leverage a recent California initiative in which 28 local EDs received funding to implement or expand routine, opt-out HIV screening. Specifically, in Aim 2, Dr. Bennett will train in implementation science to create a typology of the screening strategies used by these EDs; this work will be informed by a stakeholder group of ED leaders with efforts guided by the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework. In Aim 3, Dr. Bennett will obtain additional training in qualitative methods to employ semi-structured interviews of a diverse cohort – frontline ED providers implementing HIV screening and persons tested for HIV at these EDs – at a subset of these sites to illuminate firsthand barriers and facilitators encountered during the real-world implementation of HIV screening programs, guided by the updated Consolidated Framework for Implementation Research (CFIR). This K08 award is designed to leverage Dr. Bennett’s clinical training and build upon their background in epidemiology and health services research. This innovative K08 responds to several NIH priorities for HIV and HIV-related research and will aid decision makers in identifying which strategies work for different communities. Overall, this work will advance EHE’s mission to make HIV screening routine in all settings that serve a high volume of racial, ethnic, sexual, and gender minority groups, with focused approaches to enable testing for more people at risk for HIV.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15386", "attributes": { "award_id": "1UM1TR004772-01", "title": "Dartmouth Clinical and Translational Science Institute", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Advancing Translational Sciences (NCATS)" ], "program_reference_codes": [], "program_officials": [ { "id": 21567, "first_name": "Jamie Mihoko", "last_name": "Doyle", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2024-07-25", "end_date": "2031-06-30", "award_amount": 4073191, "principal_investigator": { "id": 31986, "first_name": "Steven L", "last_name": "Bernstein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 31987, "first_name": "KEITH D.", "last_name": "PAULSEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 31988, "first_name": "Anna N. A.", "last_name": "Tosteson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2072, "ror": "", "name": "DARTMOUTH-HITCHCOCK CLINIC", "address": "", "city": "", "state": "NH", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic brought into stark relief the many healthcare challenges facing individuals living in rural areas—the compounded needs of an aging population, geographic dispersion, inadequate public transportation, spotty internet service, spikes in substance use, vaccine hesitancy. These disparities—like most public health problems—reflect a complex interplay of biological, environmental, psychological, social, and systems-level factors. At the same time, the pandemic highlighted potential solutions and spurred a wealth of research in healthcare delivery science in rural areas. Much of this work was conducted by scientists affiliated with SYNERGY, Dartmouth’s Clinical and Translational Science Institute, founded in 2013. SYNERGY faculty reported the expanded use of telehealth, digital health, machine learning; strengthened partnerships between healthcare systems and community health centers; and developed a “COVID compass” to guide policymaking. Our work in this area, centered in SYNERGY’s earliest years, has deepened our commitment to translational science that centers rural healthcare delivery and health equity, while exploring the full spectrum of translational science and workforce development. Hence, we propose to return SYNERGY to the national CTSA consortium. The overarching goal of this application is to continue to spur innovation in clinical and translational science with a focus on rural healthcare, in collaboration with other CTSA hubs, and to study a new model to catalyze T3 translational science in healthcare settings. SYNERGY reflects a close partnership between Dartmouth Health (DH) and Dartmouth College (DC). DH is the largest healthcare system in New Hampshire, with its flagship hospital in a rurally designated area. DC brings the resources of a research- intensive college, including schools of medicine, engineering, business, and graduate studies. SYNERGY includes our new Center for Rural Healthcare Delivery Science and key regional collaborators, including the Northern New England Clinical Translational Research Network (a partnership between MaineHealth and the University of Vermont), a Veterans Affairs hospital, community groups, and a “pipeline” program to grow the scientific workforce. SYNERGY’s goals are to (1) Accelerate the delivery of evidence-based diagnostics, therapeutics, and processes to address the healthcare needs of rural communities; (2) Assure the availability of timely, actionable patient- and population-level data to mitigate the translational block of “siloing” between translational scientists and healthcare system leadership by deploying a novel coproduction learning health system (LHS); (3) Train the next generation of translational scientists, with a particular focus on identifying future leaders in healthcare delivery science and rural health; (4) Disseminate these practices and lessons learned within the CTSA community through engagement with subnetworks addressing rural health, implementation science, and learning health systems science; and (5) Involve local communities in the design, conduct, analysis, and dissemination of our work, while engaging in studies of stakeholder engagement.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1405, "count": 14046 } } }