Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=other_investigators" }, "data": [ { "type": "Grant", "id": "6585", "attributes": { "award_id": "3UG1DA049435-03S1", "title": "Greater Southern California Node of the Clinical Trials Network", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 22071, "first_name": "Ronald", "last_name": "Dobbins", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-06-01", "end_date": "2024-02-29", "award_amount": 117145, "principal_investigator": { "id": 22072, "first_name": "YIH-ING", "last_name": "HSER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22073, "first_name": "Larissa Jeanette", "last_name": "Mooney", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 818, "ror": "", "name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "The overarching goal of the Greater Southern California Node (GSCN) of the National Drug Abuse Treatment Clinical Trials Network (CTN) is to expand access to and improve outcomes of treatments for substance use disorders (SUDs)—with a special emphasis on opioid use disorder (OUD) —by collaboratively developing and testing effective and sustainable interventions for OUD that can be delivered in diverse healthcare settings. To achieve this goal, we have assembled (1) local, regional, and state-wide healthcare networks that serve millions of individuals, (2) investigators who have conducted seminal work on development and testing of pharmacological and behavioral interventions for SUDs, and (3) researchers with expertise in implementation strategies, data science, and innovative technologies to support treatment delivery and related research. Building upon investigators' past and current efforts, the specific aims of GSCN are: Aim 1. Lead and contribute to the development of new research protocols designed to increase access to treatments for OUD and to improve treatment outcomes; Aim 2. Support and participate in multi-site CTN projects and other CTN activities; and Aim 3. Disseminate research findings and provide innovative training to impact clinical practice. The GSCN research agenda will initially focus on four priority areas: (1) developing and testing effective medication and behavioral interventions for OUD and related comorbidities, (2) applying implementation science to deliver and expand OUD treatment in multiple healthcare settings, (3) leveraging eHealth (e.g., electronic health record systems) and data science for discovery and generation of innovative hypotheses and approaches to improve treatment for OUD, and (4) building on mHealth (e.g., smartphone- assisted interventions) and other technologies (e.g., telemedicine) to expand OUD treatment access and utilization. The GSCN research agenda reflects its capacity to collaboratively expand CTN efforts to develop and implement innovative approaches to improve treatment for OUD and other SUDs.", "keywords": [ "Address", "Area", "Behavior Therapy", "California", "Cellular Phone", "Clinical Research", "Clinical Treatment", "Clinical Trials Network", "Collaborations", "Concept Review", "Data Science", "Development", "Drug abuse", "Electronic Health Record", "Faculty", "Generations", "Goals", "Health", "Health Care Research", "Health Services Accessibility", "Health care facility", "Healthcare", "Helping to End Addiction Long-term", "Improve Access", "Individual", "Interdisciplinary Study", "Intervention", "Intervention Studies", "Journals", "Lead", "Leadership", "Mission", "Modeling", "Morbidity - disease rate", "Multi-Institutional Clinical Trial", "National Institute of Drug Abuse", "New York", "Pharmaceutical Preparations", "Pharmacology", "Pharmacotherapy", "Population", "Population Heterogeneity", "Principal Investigator", "Protocols documentation", "Public Health", "Research", "Research Infrastructure", "Research Personnel", "Research Priority", "Research Support", "Seminal", "Substance Use Disorder", "System", "Talents", "Technology", "Telemedicine", "Testing", "Training", "Treatment Effectiveness", "Treatment outcome", "United States", "United States National Institutes of Health", "Vulnerable Populations", "Work", "base", "clinical practice", "clinical trial implementation", "comorbidity", "design", "eHealth", "health care service organization", "health care settings", "implementation science", "implementation strategy", "improved", "improved outcome", "innovation", "innovative technologies", "mHealth", "meetings", "mortality", "opioid epidemic", "opioid use disorder", "overdose death", "protocol development", "response", "rural area", "rural setting", "service delivery", "student training", "substance use treatment", "treatment services", "uptake" ], "approved": true } }, { "type": "Grant", "id": "6594", "attributes": { "award_id": "3U2CNR014637-09S1", "title": "Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22101, "first_name": "Karen", "last_name": "Kehl", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2013-09-28", "end_date": "2023-06-30", "award_amount": 217698, "principal_investigator": { "id": 22102, "first_name": "JEAN S", "last_name": "KUTNER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22103, "first_name": "KATHRYN I", "last_name": "POLLAK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 22104, "first_name": "Christine S", "last_name": "Ritchie", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity- building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.", "keywords": [ "Address", "Administrative Coordination", "Affect", "Age", "American", "Award", "Awareness", "Behavioral", "COVID-19", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Caregiver research", "Caregivers", "Caring", "Clinical", "Clinical Research", "Cohort Studies", "Color", "Communication", "Communities", "Consultations", "Contracts", "Data", "Decision Making", "Development", "Disincentive", "Economics", "Enrollment", "Environment", "Epidemic", "Ethics", "Extended Family", "Face", "Family", "Female", "Foundations", "Funding", "Generations", "Goals", "Grant", "Health", "Health Campaign", "Health behavior", "Healthcare", "Hearing", "Home", "Home Health Aides", "Hospice Care", "Hospitals", "Immigrant", "Incentives", "Individual", "Informatics", "Infrastructure", "Internships", "Interview", "Measurement", "Medical", "Methodological Studies", "Methodology", "Minority Groups", "Modeling", "Multi-Institutional Clinical Trial", "National Institute of Nursing Research", "Neighborhoods", "New York City", "Nurses", "Palliative Care", "Patients", "Persons", "Pharmacists", "Physicians", "Policies", "Population", "Population Heterogeneity", "Poverty", "Process", "Productivity", "Public Health", "Quality of life", "Research", "Research Activity", "Research Personnel", "Risk", "Role", "SARS-CoV-2 infection", "SARS-CoV-2 transmission", "Science", "Site", "Source", "Structure", "Travel", "Trust", "Underrepresented Populations", "Underserved Population", "Vaccination", "Voice", "Vulnerable Populations", "Woman", "Work", "adverse outcome", "base", "care seeking", "community engagement", "community organizations", "data privacy", "data repository", "end of life", "ethnic minority population", "experience", "federal poverty level", "health literacy", "high risk", "hospice environment", "improved", "influenza virus vaccine", "insight", "multi-site trial", "multidisciplinary", "pandemic disease", "peer", "personal protective equipment", "racial minority", "research study", "skills", "social", "social vulnerability", "socioeconomics", "statistics", "therapy design", "training opportunity", "uptake", "vaccine hesitancy" ], "approved": true } }, { "type": "Grant", "id": "6594", "attributes": { "award_id": "3U2CNR014637-09S1", "title": "Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22101, "first_name": "Karen", "last_name": "Kehl", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2013-09-28", "end_date": "2023-06-30", "award_amount": 217698, "principal_investigator": { "id": 22102, "first_name": "JEAN S", "last_name": "KUTNER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22103, "first_name": "KATHRYN I", "last_name": "POLLAK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 22104, "first_name": "Christine S", "last_name": "Ritchie", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity- building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.", "keywords": [ "Address", "Administrative Coordination", "Affect", "Age", "American", "Award", "Awareness", "Behavioral", "COVID-19", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Caregiver research", "Caregivers", "Caring", "Clinical", "Clinical Research", "Cohort Studies", "Color", "Communication", "Communities", "Consultations", "Contracts", "Data", "Decision Making", "Development", "Disincentive", "Economics", "Enrollment", "Environment", "Epidemic", "Ethics", "Extended Family", "Face", "Family", "Female", "Foundations", "Funding", "Generations", "Goals", "Grant", "Health", "Health Campaign", "Health behavior", "Healthcare", "Hearing", "Home", "Home Health Aides", "Hospice Care", "Hospitals", "Immigrant", "Incentives", "Individual", "Informatics", "Infrastructure", "Internships", "Interview", "Measurement", "Medical", "Methodological Studies", "Methodology", "Minority Groups", "Modeling", "Multi-Institutional Clinical Trial", "National Institute of Nursing Research", "Neighborhoods", "New York City", "Nurses", "Palliative Care", "Patients", "Persons", "Pharmacists", "Physicians", "Policies", "Population", "Population Heterogeneity", "Poverty", "Process", "Productivity", "Public Health", "Quality of life", "Research", "Research Activity", "Research Personnel", "Risk", "Role", "SARS-CoV-2 infection", "SARS-CoV-2 transmission", "Science", "Site", "Source", "Structure", "Travel", "Trust", "Underrepresented Populations", "Underserved Population", "Vaccination", "Voice", "Vulnerable Populations", "Woman", "Work", "adverse outcome", "base", "care seeking", "community engagement", "community organizations", "data privacy", "data repository", "end of life", "ethnic minority population", "experience", "federal poverty level", "health literacy", "high risk", "hospice environment", "improved", "influenza virus vaccine", "insight", "multi-site trial", "multidisciplinary", "pandemic disease", "peer", "personal protective equipment", "racial minority", "research study", "skills", "social", "social vulnerability", "socioeconomics", "statistics", "therapy design", "training opportunity", "uptake", "vaccine hesitancy" ], "approved": true } }, { "type": "Grant", "id": "6596", "attributes": { "award_id": "5R01ES008739-24", "title": "The Effect of Pesticide Exposure on Cognitive and Brain Development in Latino Children: PACE5", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 22107, "first_name": "Claudia L", "last_name": "Thompson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1996-09-30", "end_date": "2023-05-31", "award_amount": 563104, "principal_investigator": { "id": 22108, "first_name": "Thomas A.", "last_name": "Arcury", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22109, "first_name": "Paul", "last_name": "Laurienti", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1149, "ror": "", "name": "WAKE FOREST UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NC", "zip": "", "country": "United States", "approved": true }, "abstract": "Concern is mounting that commonly used pesticides are detrimental to children. Children are rapidly undergoing cognitive, sensory, and motor development, and disruption of normal maturation can have life-long consequences. The extant literature strongly indicates that prenatal exposure to pesticides leads to abnormal neurobehavioral development. A recent brain imaging study further showed that prenatal pesticide exposure is associated with disrupted anatomical brain development. However, results concerning the consequences of postnatal pesticide exposure are much less conclusive. Some studies have reported neurobehavioral deficits following postnatal pesticide exposure, but just as many studies have reported no negative consequences. Currently there are no studies that assess the effects of postnatal pesticide exposure on brain development using anatomical or functional brain imaging. More conclusive research on the effects of postnatal exposure on neurodevelopment requires a highly exposed population, a longitudinal design, and careful quantification of exposure and outcomes. We propose a two-group, prospective, longitudinal study of Latino children 7 years of age with quarterly measurement of cumulative pesticide exposure using passive dosimetry wristbands as well as documentation of prenatal and early life exposure through life history techniques. Children from Latino seasonal farmworker families will be compared with children from Latino families not participating in farm work and not living in an agricultural environment. Children in Latino farmworker families are at particularly high risk of exposure. Not only are pesticides frequently used in their low quality housing, but they are also exposed to agricultural pesticides used in nearby fields brought home by parental/sibling farmworkers on clothing. Children will be followed for 2 years with measurement of neurobehavioral function at baseline, 1 year, and 2 years. Neuroimaging will be performed in a subset of participants with structural and functional brain organization assessed at baseline and two years later. Specific aims for this project are: Aim 1: Compare 2-year longitudinal and prenatal/early life pesticide exposure between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Aim 2: Compare 2-year longitudinal neurobehavioral and emotional and behavioral functioning among children of Latino seasonal farmworkers relative to children of Latino parents who are not farmworkers. Aim 3: Compare 2-year longitudinal anatomical and functional brain development between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Our nearly two decades of environmental justice (EJ) and community-based participatory research (CBPR) on pesticide exposure with farmworkers and their families provides an auspicious context to engage this vulnerable population in a study of both scientific and environmental justice importance.", "keywords": [ "7 year old", "Address", "Affect", "Agriculture", "Anatomy", "Area", "Behavioral", "Blood", "Brain", "Brain imaging", "Calendar", "Chemicals", "Child", "Child Development", "Childhood", "Cholinesterases", "Chronic", "Clothing", "Cognitive", "Communities", "Complex", "Conflict (Psychology)", "Development", "Disease", "Documentation", "Dose", "Emotional", "Environment", "Environmental Risk Factor", "Exhibits", "Exposure to", "Family", "Farming environment", "Goals", "Home", "Housing", "Individual", "Latino", "Life", "Literature", "Longevity", "Longitudinal Studies", "Measurement", "Measures", "Metabolism", "Motor", "National Institute of Environmental Health Sciences", "Neurocognitive", "Organophosphates", "Outcome", "Parents", "Participant", "Performance", "Pest Control", "Pesticides", "Population", "Predisposition", "Published Comment", "Reporting", "Research", "Risk", "Sampling", "Schools", "Sensory", "Siblings", "Socioeconomic Status", "Strategic Planning", "Structure", "Study of Latinos", "Surface", "Techniques", "Time", "Vulnerable Populations", "Work", "agricultural pesticide", "community based participatory research", "developmental disease", "disorder risk", "dosimetry", "early life exposure", "environmental health disparity", "environmental justice", "farm worker", "gray matter", "health disparity", "high risk", "imaging study", "life history", "longitudinal design", "neurobehavioral", "neurodevelopment", "neuroimaging", "neuroimaging marker", "neurotoxic", "peer", "pesticide exposure", "postnatal", "prenatal", "prenatal exposure", "prospective", "stressor" ], "approved": true } }, { "type": "Grant", "id": "6605", "attributes": { "award_id": "3U54EB015408-09S2", "title": "Point of Care Technology Research Center in Primary Care", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22147, "first_name": "Tiffani Bailey", "last_name": "Lash", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2012-07-01", "end_date": "2023-05-31", "award_amount": 3947568, "principal_investigator": { "id": 22148, "first_name": "John A", "last_name": "Parrish", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22149, "first_name": "Steven", "last_name": "Schachter", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Summary/Abstract: Overall The Point-of-Care Technology Research Center in Primary Care proposes to further develop a national “center-without-walls” for rapid transformation of emerging point-of-care technologies into commercially viable, clinically focused solutions for improving primary healthcare. The Center was established by the Consortia for Improving Medicine through Innovation and Technology (CIMIT), a consortium of research institutions, universities, military medicine centers and hospitals throughout the US with international affiliates at University of Manchester-UK (MIMIT), Barcelona (The Center for the Integration of Medicine and Innovative Technologies in Catalonia) and Singapore (A*-STAR/Eastern Health Alliance). CIMIT established the Point-of- Care Technology Research Center in Primary Care under a Cooperative Agreement (U54) award from National Institute of Biomedical Imaging and Bioengineering (NIBIB) in 2012 and the Center created a national network of research sites, harnessing the power of multidisciplinary collaboration to speed the translation of high-impact research into primary care practice and broader dissemination by commercially licensable opportunities. We will build upon our proven approach to needs-driven primary healthcare technology innovation to expand and significantly enhance our Center. The Center’s overall objective is to build upon the progress made under the previous U54 award and offer expanded support to teams through the integrated functional elements of the proposed enhanced Center. In so doing, the Center will offer a portfolio of synergistic support to teams with innovative solutions through defined interfaces and hand offs throughout the innovation process while continuously improving the Center’s processes of finding, funding, facilitating, and following projects. The long-term goal is to create a dynamic, sustainable national network that identifies key unmet needs in the delivery of primary care as well as promising emerging technologies and then to accelerate their translation into clinical applications for broad impact in primary care medicine through high-quality translational and clinical research.", "keywords": [ "Address", "Area", "Award", "Caring", "Chronic Disease", "Clinical", "Clinical Research", "Collaborations", "Elements", "Emerging Technologies", "Engineering", "Environment", "Funding", "Goals", "Hand", "Health", "Health Alliance", "Health Technology", "Healthcare", "Hospitals", "Institution", "Interdisciplinary Study", "International", "Laboratories", "Licensing", "Medicine", "Methodology", "Military Medicine", "Modeling", "National Institute of Biomedical Imaging and Bioengineering", "Outcome", "Patients", "Performance", "Point of Care Technology", "Primary Care Physician", "Primary Health Care", "Process", "Recommendation", "Research", "Resources", "Scientist", "Singapore", "Site", "Speed", "Students", "Technology", "Testing", "Training", "Translational Research", "Translations", "U-Series Cooperative Agreements", "Universities", "aging population", "care providers", "clinical application", "commercialization", "design", "experience", "follow-up", "improved", "industry partner", "innovation", "innovative technologies", "meetings", "point of care", "prototype" ], "approved": true } }, { "type": "Grant", "id": "6607", "attributes": { "award_id": "3D43TW007261-15S1", "title": "iCREATE: Increasing Capacity in Research in Eastern Europe", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Fogarty International Center (FIC)" ], "program_reference_codes": [], "program_officials": [ { "id": 22152, "first_name": "MARYA", "last_name": "LEVINTOVA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2005-05-26", "end_date": "2022-08-31", "award_amount": 76608, "principal_investigator": { "id": 22153, "first_name": "CORINNE", "last_name": "PEEK-ASA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22154, "first_name": "Diana", "last_name": "Rus", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "The global injury burden is disproportionately concentrated in low and middle income countries (LMIC).This project, to be named ICREATE (Injury Capacity in Research in EAsTern Europe), introduces injury and violence training to the LMIC countries of Armenia, Georgia, and Moldova, which are strategic global priorities due to their political and economic ties to the Middle East, Russia, and Europe. Capacity for medical and public health education in these countries has been growing, but injury and violence is not currently addressed. Our University of Iowa training program builds on a successful decade of capacity building for injury and violence research in Romania, where our partnership helped establish the Cluj School of Public Health and its independently-funded injury research unit. Training will be conducted in partnership, demonstrating a successful transition in Romania from trainees to trainers. The aims of our training program are to: train a critical mass of researchers from Armenia, Georgia, and Moldova to conduct innovative research; facilitate the transition of trainees to positions of leadership; develop our partner institutions as sustainable centers of excellence in injury research and education; and, engage partners to translate research into effective prevention and treatment programs. Based on the needs of our partner countries and expertise of the project leadership, we will focus on three areas: road traffic safety; violence against women and children; and, acute care. Our training program will prioritize long-term MPH and PhD training to build research and leadership skills focused on injury and violence prevention. Through a European Union TEMPUS grant, our partner institutions have MPH programs that allow transfer of credit. Within this structure, we will integrate two injury and violence courses; a Global Injury and Violence Summer Symposium; and a mentored research project. Injury and violence training will occur at the University of Iowa and Cluj School of Public Health. PhD training will occur in the strong research environment of the University of Iowa, which includes a CDC-funded Injury Prevention Research Center. We plan for these activities to build sustainable research and education capacity that will lead to reductions in the burden of traumatic injuries and violence.", "keywords": [ "Address", "Area", "Armenia", "Centers for Disease Control and Prevention (U.S.)", "Child", "Country", "Doctor of Philosophy", "Eastern Europe", "Economics", "Education", "Environment", "Europe", "European Union", "Funding", "Grant", "Injury", "Institution", "Iowa", "Leadership", "Medical", "Mentors", "Middle East", "Moldova", "Names", "Politics", "Positioning Attribute", "Prevention Research", "Prevention program", "Public Health Education", "Public Health Schools", "Research", "Research Personnel", "Research Project Grants", "Romania", "Russia", "Safety", "Structure", "Training", "Training Programs", "Translating", "Traumatic injury", "Universities", "Violence", "acute care", "base", "injury burden", "injury prevention", "innovation", "low and middle-income countries", "programs", "skills", "symposium", "treatment program", "violence against women", "violence prevention" ], "approved": true } }, { "type": "Grant", "id": "6609", "attributes": { "award_id": "3UH3AT009651-04S1", "title": "Advancing Research on Mechanisms of Resilience (ARMOR): Prospective Longitudinal", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Complementary and Integrative Health (NCCIH)" ], "program_reference_codes": [], "program_officials": [ { "id": 22157, "first_name": "Elizabeth M", "last_name": "Ginexi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-09-01", "end_date": "2023-02-28", "award_amount": 248458, "principal_investigator": { "id": 22158, "first_name": "Christopher R", "last_name": "Erbes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22159, "first_name": "MELISSA A.", "last_name": "POLUSNY", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 764, "ror": "https://ror.org/017zqws13", "name": "University of Minnesota", "address": "", "city": "", "state": "MN", "zip": "", "country": "United States", "approved": true }, "abstract": "Background: Resilience is defined as the capacity to adapt successfully through multiple processes in response to adverse events. While explanatory models are still in their infancy, theoretical and empirical evidence suggest that self-regulatory processes may underlie resilient functioning. This proposal will develop (Phase 1, Year 1) and then implement (Phase 2, Years 2-5) a study of 1,200 National Guard recruits in the first two years of their enlistment in order to identify patterns and processes of adaptive (resilient) functioning in the face of Basic Combat Training (BCT) and other adverse events. Aims: The aims for Phase 1 are focused on planning and preparing for a longitudinal study of resilience in National Guard recruits and include: 1) Use prior datasets to develop statistical algorithms for selecting ilot baseline data collection procedures to determine feasibility of enrollment and response rate targets for longitudinal study, 3) Develop and refine contextualized measures of National Guard training stressor exposure, and 4) Evaluate the feasibility and acceptability of neurobehavioral markers of resilience processes. During Phase 2, a comprehensive model of resilience will be investigated using a four-year, mixed-method, longitudinal study to participants with high and low probabilities of resilience, 2) P 1) Characterize latent trajectories of adjustment among new military recruits beginning prior to BCT over two years, 2) Identify promotive and protective predictors of resilient functioning in National Guard soldiers, and 3) Investigate neurobehavioral pathways of self-regulation predictive of resilience trajectories in new military recruits. Procedures and Analyses: In Phase 1, prediction algorithms will be established using analysis of datasets gathered in prior National Guard studies. The measurement of BCT stressors, and feasibility of Phase 2 recruitment plans, will involve online surveys of 100 National Guard recruits before, during and immediately after BCT. The feasibility and acceptability of neurobiological measures through imaging and laboratory tasks piloting procedures will be assessed with 10 recruits undergoing procedures before and after BCT. In Phase 2, on-line self-reports of symptoms (depression, anxiety, alcohol or drug use), adaptive social functioning, and promotive, protective, and risk factors will be collected before and at 4 time points after BCT with 1200 National Guard recruits. Growth mixture modeling will establish resilient and non-resilient trajectories of adaptive functioning. Aim 2 will use predictive modeling of trajectories using predictors collected during the baseline and subsequent time points. In Aim 3, 120 recruits will complete laboratory tasks (Farmer's task, go/no-go task, dot probe task, performance monitoring task) before and after BCT while undergoing MRI or EEG scans. Analyses will determine if these tasks can discriminate between recruits in the resilient vs. non- resilient trajectories of functioning established in Aim 1.", "keywords": [ "Adverse event", "Alcohol consumption", "Anxiety", "Area", "Attention", "Behavior", "Behavioral", "Biological", "Cognition", "Cognitive", "Collaborations", "Data Collection", "Data Set", "Drug usage", "Electroencephalography", "Emotions", "Enrollment", "Environment", "Evaluation", "Exposure to", "Goals", "Growth", "Healthcare Systems", "Image", "Individual Differences", "Informal Social Control", "Integrative Medicine", "Laboratories", "Life", "Longevity", "Longitudinal Studies", "Longitudinal cohort study", "Magnetic Resonance Imaging", "Measurement", "Measures", "Mental Depression", "Mental Health", "Methods", "Military Personnel", "Mind-Body Intervention", "Minnesota", "Modeling", "Monitor", "Neurobiology", "Outcome", "Participant", "Pathway interactions", "Patient Self-Report", "Pattern", "Personality Traits", "Phase", "Pilot Projects", "Populations at Risk", "Prevention", "Probability", "Procedures", "Process", "Psyche structure", "Psychopathology", "Psychophysiology", "Regulation", "Research", "Research Personnel", "Risk", "Risk Factors", "Scanning", "Services", "Social Functioning", "Soldier", "Spouses", "Statistical Algorithm", "Statistical Models", "Stress", "Substance abuse problem", "Surveys", "Symptoms", "Task Performances", "Time", "Training", "Universities", "Work", "acceptability and feasibility", "base", "cognitive neuroscience", "cohort", "combat training", "conduct problem", "contextual factors", "cost", "developmental psychology", "farmer", "field study", "first responder", "flexibility", "high risk", "infancy", "military service", "neurobehavioral", "novel", "physical conditioning", "prediction algorithm", "predictive modeling", "preventive intervention", "prospective", "protective factors", "recruit", "resilience", "response", "service member", "sexual risk taking", "social", "stressor" ], "approved": true } }, { "type": "Grant", "id": "6610", "attributes": { "award_id": "3R01AI151176-03S1", "title": "Accelerating viral outbreak detection in US cities using mechanistic models, machine learning and diverse geospatial data", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 22194, "first_name": "BROOKE ALLISON", "last_name": "Bozick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-07-07", "end_date": "2023-01-31", "award_amount": 114457, "principal_investigator": { "id": 22195, "first_name": "ALISON P", "last_name": "GALVANI", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22196, "first_name": "LAUREN ANCEL", "last_name": "MEYERS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 452, "ror": "https://ror.org/03v76x132", "name": "Yale University", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "Project Abstract/Summary Our interdisciplinary research team will develop algorithms to accelerate the detection of respiratory virus outbreaks at an unprecedented local scale in US cities. We propose to advance outbreak detection by combining machine learning data integration methods and spatial models of disease transmission. The dynamic models that will be developed will provide mechanistic engines for distinguishing typical from atypical disease trends and the optimization methods evaluate the informativeness of data sources to achieve specified public health goals through the rapid evaluation of diverse input data sources. Working with local healthcare and public health leaders, we will translate the algorithms into user-friendly online tools to support preparedness plans and decision-making. Our proposed research is organized around three major aims. In Aim 1, we will apply machine learning and signal processing methods to build systems that track the earliest indicators of emerging outbreaks within seven US cities. We will evaluate non-clinical data reflecting early and mild symptoms as well as clinical data covering underserved communities and geographic and demographic hotspots for viral emergence. In Aim 2, we will develop sub-city scale models reflecting the syndemics of co-circulating respiratory viruses and chronic respiratory diseases (CRD) that can exacerbate viral infections. We will infer viral transmission rates and socio-environmental risk cofactors by fitting the model to respiratory disease data extracted from millions of electronic health records (EHRs) for the last nine years. We will then partner with clinical and EHR experts to translate our models into the first outbreak detection system for severe respiratory viruses that incorporates EHR data on CRDs. Using machine learning techniques, we will further integrate other surveillance, environmental, behavioral and internet predictor data sources to maximize the accuracy, sensitivity, speed and population coverage of our algorithms. In Aim 3, we will develop an open-access Python toolkit to facilitate the integration of next generation data into outbreak surveillance models. This project will produce practical early warning algorithms for detecting emerging viral threats at high spatiotemporal resolution in several US cities, elucidate socio-geographic gaps in current surveillance systems and hotspots for viral emergence, and provide a robust design framework for extrapolating these algorithms to other US cities.", "keywords": [ "Absenteeism", "Address", "African", "Age", "Algorithm Design", "Algorithms", "Area", "Articulation", "Bayesian Method", "Behavioral", "Caring", "Chronic", "Chronic Disease", "Cities", "Climate", "Clinical", "Clinical Data", "Collaborations", "Communicable Diseases", "Data", "Data Sources", "Decision Making", "Detection", "Disease", "Disease Outbreaks", "Disease Surveillance", "Disease model", "Ebola", "Electronic Health Record", "Ensure", "Epidemic", "Evaluation", "Geography", "Goals", "Health", "Healthcare", "Home", "Human", "Individual", "Infection", "Influenza", "Influenza A Virus H1N1 Subtype", "Interdisciplinary Study", "International", "Internet", "Intervention", "Location", "Machine Learning", "Medical", "Methodology", "Methods", "Mexico", "Modeling", "Neighborhoods", "Pollution", "Population", "Prevention", "Public Health", "Pythons", "Readiness", "Reporting", "Research", "Resolution", "Respiratory Disease", "Risk", "Rural", "Schools", "Sentinel", "Series", "Signal Transduction", "Social Environment", "Specific qualifier value", "Speed", "Subgroup", "Surveillance Modeling", "Symptoms", "System", "Techniques", "Testing", "Time", "Translating", "Uncertainty", "Validation", "Viral", "Virus", "Virus Diseases", "Visualization", "Work", "World Health Organization", "austin", "base", "chronic respiratory disease", "cofactor", "comorbidity", "dashboard", "data acquisition", "data handling", "data integration", "design", "detection method", "detection platform", "digital", "disease transmission", "diverse data", "epidemiologic data", "epidemiological model", "experimental study", "flexibility", "global health", "health care availability", "health goals", "high risk", "high risk population", "influenza outbreak", "influenzavirus", "innovation", "insight", "metropolitan", "next generation", "novel", "outcome prediction", "pandemic disease", "public health intervention", "respiratory virus", "school district", "signal processing", "simulation", "social media", "sociodemographic group", "socioeconomics", "sound", "spatiotemporal", "stem", "tool", "transmission process", "trend", "underserved community", "user-friendly", "viral transmission" ], "approved": true } }, { "type": "Grant", "id": "6611", "attributes": { "award_id": "3R01HL151292-03S1", "title": "Determinants and Outcomes of Nicotine Metabolite Ratio in HIV + Smokers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 22197, "first_name": "Sean", "last_name": "Coady", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-02-10", "end_date": "2023-01-31", "award_amount": 432874, "principal_investigator": { "id": 22198, "first_name": "Rebecca", "last_name": "Ashare", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22199, "first_name": "ROBERT", "last_name": "GROSS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Smoking rates in people living with HIV (PLWH) exceed 40%, nearly 3x uninfected individuals. Cardiovascular disease (CVD), including myocardial infarction (MI), is common in PLWH, in part due to smoking. Despite availability of smoking cessation pharmacotherapy, cessation rates among PLWH remain low. Frameworks for understanding smoking cessation emphasize biological, psychological, and social factors. However, critical gaps in identifying and addressing biological factors related to tobacco use among PLWH remain. In the general population, the rate at which nicotine is metabolized is an important biomarker of smoking behavior and treatment response. Greater CYP2A6 enzyme activity, as measured by higher nicotine metabolite ratios (NMR), results in: faster nicotine clearance, more cigarettes smoked per day, higher nicotine dependence, greater severity of withdrawal symptoms and reduced cessation. Recent work from our lab found significantly higher NMRs in HIV suggesting effects in HIV may differ. Differences in NMR may be affected by HIV infection and/or antiretroviral therapy (ART). HIV itself may increase NMR as CYP2A6 is induced by inflammation, which may mirror dysregulation caused by HIV infection. ART drugs may alter NMR via other mechanisms: they may reduce NMR by reducing inflammation via viral suppression, reduce NMR via CYP2A6 inhibition, or increase NMR via CYP2A6 induction. And these mechanisms may differ by ART drug. Moreover, the impact of higher NMR on smoking and complications of smoking (e.g., MI) among PLWH are currently unknown. Higher NMR influences smoking topography (e.g., higher puff volume), which is associated with greater exposure to inducers of inflammation and coagulation. While higher NMR increases lung cancer risk, its effect on MI is unknown. We propose to: 1) determine whether NMR is faster after HIV infection, relative to before, 2) determine whether viral suppression decreases NMR and whether the effect differs by ART drugs which do and do not alter CYP2A6 activity, 3) determine whether lower NMR predicts higher smoking cessation rates in PLWH on ART with viral suppression, and 4) determine whether NMR is a risk factor for MI in PLWH. We will conduct retrospective cohort studies with paired specimens for Aims 1 and 2 and nested case-control studies for Aims 3 and 4. Data and specimens will be obtained from the Multicenter AIDS Cohort Study (MACS) /Women's Intra-agency Health Study (WIHS) and the CFAR Network Integrated Clinical Systems (CNICS) databases and specimen repositories. Elucidating the relationship between HIV, ART, and smoking, may lead to the development of targeted interventions for smokers with HIV infection such as adding drugs that decrease CYP2A6 activity or switching off ART drugs that induce CYP2A6. If NMR is a predictor of MI, it will help us identify a subpopulation of PLWH in more urgent need of interventions. Smokers with HIV lose more life years to tobacco use than to HIV, partly due to increases in smoking-related comorbidities including CVD. Thus, interventions targeting HIV+ smokers may substantially reduce mortality globally.", "keywords": [ "AIDS/HIV problem", "Address", "Affect", "Biological Factors", "Biological Markers", "Biological Specimen Banks", "Blood", "CYP2B6 gene", "Cardiovascular Diseases", "Cardiovascular system", "Clinical", "Coagulation Process", "Cohort Studies", "Complex", "Cotinine", "Country", "Data", "Database Management Systems", "Development", "Enzymes", "Exposure to", "Future", "General Population", "HIV", "HIV Infections", "HIV antiretroviral", "Health", "Heart", "Hepatic", "Income", "Individual", "Infection", "Inflammation", "Intervention", "Lead", "Life", "Life Expectancy", "Lipopolysaccharides", "Lung", "Malignant Neoplasms", "Malignant neoplasm of lung", "Measures", "Metabolism", "Morbidity - disease rate", "Myocardial Infarction", "National Heart Lung and Blood Institute", "Nested Case-Control Study", "Nicotine", "Nicotine Dependence", "Outcome", "Persons", "Pharmaceutical Preparations", "Pharmacotherapy", "Prognosis", "Psychological Factors", "Randomized", "Research", "Retrospective cohort study", "Risk", "Risk Factors", "Severities", "Sleep", "Smoke", "Smoker", "Smoking", "Smoking Behavior", "Smoking Cessation Intervention", "Specimen", "The Multicenter AIDS Cohort Study", "Time", "Tobacco use", "Viral", "Withdrawal Symptom", "Woman", "Work", "antiretroviral therapy", "behavioral response", "cancer risk", "cardiovascular risk factor", "cigarette smoke", "comorbidity", "efavirenz", "enzyme activity", "health disparity", "hydroxycotinine", "inhibitor/antagonist", "innovation", "interest", "isoniazid", "low and middle-income countries", "mortality", "novel marker", "randomized trial", "smoking cessation", "smoking prevalence", "social factors", "treatment response" ], "approved": true } }, { "type": "Grant", "id": "6613", "attributes": { "award_id": "5U19AI116484-07", "title": "Stanford/UNC Biomimetic U19 Research Center", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 22202, "first_name": "Rodolfo M.", "last_name": "Alarcon", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2015-03-01", "end_date": "2026-03-31", "award_amount": 1511551, "principal_investigator": { "id": 22203, "first_name": "MANUEL R", "last_name": "AMIEVA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22204, "first_name": "CALVIN J", "last_name": "KUO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Stanford/UNC Biomimetic U19 Research Center PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW Infectious diseases continue to pervasively afflict global health and socioeconomic stability despite substantial prevention and treatment initiatives. Respiratory and gastrointestinal pathogens rank amongst the most intractable infectious diseases, particularly notable for recurrent waves of zoonotic coronaviruses and the recent COVID-19 pandemic, engendered by SARS-CoV-2. Overall, an urgent need exists for improved in vitro experimental models of human disease to study pathogenesis and to validate therapeutics. The central mission of the Stanford/UNC Biomimetic U19 Research Center is thus to deploy novel 3-dimensional organoid culture models to elucidate the biology and therapy of respiratory and gastrointestinal infectious pathogens. Our application is a renewal of our prior Stanford NAMSED U19 Research Center and is comprised of two Cores and three research Projects, leveraging complementary and synergistic expertise of our investigators at Stanford University and the University of North Carolina. The Center continues to be led by the Multi-PIs, Calvin Kuo and Manuel Amieva, who also co-lead Core A (Administrative Core). Core B (Organoid Core) is led by Calvin Kuo and provides novel capabilities for lung and GI organoid culture, gene editing and multiplexed screening. The three Projects extensively utilize organoid biomimetics for exploration of GI and respiratory pathogens. Project 1, (PI, Manuel Amieva) investigates H. pylori and Salmonella colonization, competition and invasion in the GI tract, while Project 2 (PI, Harry Greenberg) investigates rotavirus host range, neutralization, and M cell interactions in enteric biomimetics. Project 3 (PI, Ralph Baric) is a new addition and extensively uses organoids to model SARS-CoV-2, other closely related epidemic and pre-epidemic emerging coronaviruses and 1918 H1N1 influenza to reveal common and unique host networks associated with severe pulmonary outcomes. The activities of the Stanford/UNC Biomimetic U19 Research Center reside within three overarching Aims. In Aim 1, our Center performs organoid modeling of the epithelium-pathogen interface to investigate pathogenesis, susceptibility and host range restriction. This employs robust reverse genetics and CRISPR screens to systematically manipulate host versus viral/bacterial compartments, within novel apical-basal polarity modulated distal lung/alveolar, nasal sinus, stomach and intestinal organoid systems. Aim 2 defines how SARS- CoV-2, pre-epidemic coronaviruses, rotavirus and Salmonella can perturb reciprocal cross-talk between tissue epithelium and resident immune cells. This exploits a unique 3D air-liquid interface organoid method preserving GI and lung epithelium en bloc with diverse endogenous infiltrating immune cell types without artificial reconstitution. Lastly, Aim 3 performs organoid-based evaluation of therapeutic candidates against SARS-CoV- 2, pre-epidemic coronaviruses and rotavirus in medium- to high-throughput formats including epithelium and/or immune cells. Overall, the explorations of the Stanford/UNC Biomimetic U19 Research Center directly apply advanced organoid systems to the investigation and therapy of recalcitrant infectious pathogens.", "keywords": [ "2019-nCoV", "3-Dimensional", "Acute", "Acute Respiratory Distress Syndrome", "Air", "Alveolar", "Apical", "Bacteria", "Bacterial Infections", "Basic Science", "Binding", "Biology", "Biomimetics", "COVID-19", "COVID-19 pandemic", "COVID-19 test", "CRISPR interference", "CRISPR screen", "CRISPR-mediated transcriptional activation", "Cell Communication", "Cells", "Chiroptera", "Chronic", "Clustered Regularly Interspaced Short Palindromic Repeats", "Coculture Techniques", "Communicable Diseases", "Coronavirus", "Digestion", "Disease", "Distal", "Enteral", "Epidemic", "Epithelial", "Epitopes", "Escherichia coli", "Etiology", "Exhibits", "Experimental Models", "Functional disorder", "Gastrointestinal Diseases", "Gastrointestinal tract structure", "Genes", "Genetic Screening", "Glycoproteins", "Goals", "Growth", "Helicobacter pylori", "Human", "Immune", "Immune response", "Immunity", "In Vitro", "Incubators", "Infection", "Influenza", "Influenza A Virus H1N1 Subtype", "Intestines", "Investigation", "Investigational Therapies", "Lead", "Liquid substance", "Lung", "Lung infections", "M cell", "Mediating", "Methods", "Middle East", "Middle East Respiratory Syndrome", "Middle East Respiratory Syndrome Coronavirus", "Mission", "Modeling", "Monoclonal Antibodies", "Morbidity - disease rate", "Myelogenous", "National Institute of Allergy and Infectious Disease", "Norovirus", "North Carolina", "Organoids", "Outcome", "Pathogenesis", "Pathogenicity", "Play", "Pneumonia", "Population", "Predisposition", "Prevention", "Pulmonary alveolar structure", "Recurrence", "Research", "Research Personnel", "Research Project Grants", "Resistance", "Respiratory Failure", "Respiratory Mucosa", "Respiratory Therapy", "Respiratory Tract Infections", "Role", "Rotavirus", "Route", "SARS coronavirus", "SARS-CoV-2 inhibitor", "Salmonella", "Salmonella typhi", "Salmonella typhimurium", "Severe Acute Respiratory Syndrome", "Sinus", "Stomach", "Surface", "System", "Terminal Bronchiole", "Testing", "Therapeutic", "Time", "Tissue Engineering", "Tissues", "Tumor-infiltrating immune cells", "Universities", "Viral", "Virulence", "Virus", "Virus Diseases", "Zoonoses", "absorption", "adaptive immune response", "airway epithelium", "base", "cell type", "comparative", "cytokine release syndrome", "emerging pathogen", "enteric infection", "gastric organoids", "gastrointestinal", "gastrointestinal epithel" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1442, "count": 14420 } } }