Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=other_investigators
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=other_investigators", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1397&sort=other_investigators", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=other_investigators", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=other_investigators" }, "data": [ { "type": "Grant", "id": "11475", "attributes": { "award_id": "5R01MD018206-02", "title": "CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6025, "first_name": "Crystal", "last_name": "Barksdale", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-09-19", "end_date": "2027-05-31", "award_amount": 1270963, "principal_investigator": { "id": 26650, "first_name": "Mariana", "last_name": "Lazo Elizondo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 23052, "first_name": "Ana P", "last_name": "Martinez-Donate", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 377, "ror": "https://ror.org/04bdffz58", "name": "Drexel University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 377, "ror": "https://ror.org/04bdffz58", "name": "Drexel University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Latinos in the U.S. experience significant disparities in access to mental health services due to lack of health insurance, cost of services, limited awareness of mental health resources, mental health stigma, and fear of deportation. Limited English proficiency coupled with an acute lack of bilingual and culturally competent providers further impede Latinos’ adequate access to quality mental health services. The COVID-19 pandemic has only amplified the need for mental health care and exacerbated mental health disparities for Latino communities, making it urgent to identify low-cost, effective strategies to reduce these gaps. This 5-year project seeks to develop and test a multi-level, community intervention to improve mental health outcomes and promote access to culturally appropriate mental health treatment for Latino communities in Philadelphia. CRISOL Mente will include components at various levels of the socio-ecological model: a clinic-based, stepped-care program relying on Latino lay health workers (LHW) for the delivery of mental health services (Aim 1), outreach and education activities to reduce mental health stigma in the community (Aim 2), and efforts to strengthen Latino-serving organizations’ capacity to address mental health and other syndemic conditions contributing to untreated mental health among Latinos (Aim 3). To improve mental health symptoms and engagement in care, we will recruit, train and supervise a cohort of Latino LHW who will be embedded into two Latino-serving clinics, extending the reach and effectiveness of the clinics’ mental health services. We will compare the impact of three different levels of LHW involvement: a) community outreach/navigation (i.e. screening and referral of community members); b) auxiliary care (i.e. screening, referral, and help overcoming barriers to better mental health); and c) task shifting (i.e. screening, referral, assistance, and supervised delivery of basic mental health treatment). The LHWs will also conduct outreach/education activities in the community (e.g. radio talks, info sessions, tables in community venues) to reduce mental health stigma. Our experienced and largely Latino community-academic research team will also engage in capacity building activities (i.e. monthly town halls, annual retreats, weekly newsletters, provision of trainings and technical support) with the Latino Health Collective, a coalition of Latino-serving organizations. Using mixed-methods and the RE-AIM framework, CRISOL Mente’s impact will be evaluated with clinical data, baseline and 6-month patient survey data (N=200 from each level of LHW involvement), and qualitative interviews with community members (N=30) referred to mental health services by the LHW (Aim 1); pre/post mental health stigma data from two respondent driven sampling (RDS) surveys of Latinos (N=400 each) conducted in 2022 (preliminary study) and in 2027 (Aim 2); community capacity indicators from three surveys of Latino-serving organizations conducted in 2019, 2021 (preliminary studies) and 2027, and key informant interviews (KII) with Latino-serving providers (N=30) in 2019 (preliminary study) and 2027 (Aim 3).", "keywords": [ "Acute", "Address", "Adherence", "Advocacy", "Awareness", "COVID-19 pandemic", "Caring", "Client", "Clinic", "Clinical Data", "Communication", "Communities", "Community Outreach", "Community Surveys", "Complex", "Coupled", "Data", "Development", "Discrimination", "Economics", "Education", "Education and Outreach", "Educational Activities", "Educational Status", "Effectiveness", "Evaluation", "Evidence based treatment", "Fright", "Health", "Health Insurance", "Health Resources", "Health Services Accessibility", "Healthcare", "Immigrant", "Intervention", "Interview", "Language", "Latina", "Latino", "Latino Population", "Legal", "Limited English Proficiency", "Linguistics", "Mental Depression", "Mental Health", "Mental Health Services", "Mental disorders", "Methods", "Modeling", "Newsletter", "Not Hispanic or Latino", "Occupations", "Outcome", "Patients", "Phase", "Philadelphia", "Population", "Poverty", "Provider", "Public Health", "Radio", "Reach Effectiveness Adoption Implementation and Maintenance", "Reduce health disparities", "Reporting", "Research", "Resource-limited setting", "Resources", "Respondent", "Rest", "Risk", "Sampling", "Services", "Site", "Social Conditions", "Social Work", "Stress", "Surveys", "Symptoms", "Syndrome", "Testing", "Training", "Woman", "barrier to care", "bilingualism", "clinical anxiety", "cohort", "community engaged research", "community intervention", "community setting", "cost", "cultural competence", "design", "disparity reduction", "effectiveness testing", "experience", "follow-up", "health care availability", "health disparity", "improve minority health", "improved", "informant", "member", "men", "novel", "outreach", "peer", "post-COVID-19", "post-traumatic stress", "programs", "psychological distress", "racism", "recruit", "screening", "social stigma", "syndemic" ], "approved": true } }, { "type": "Grant", "id": "7257", "attributes": { "award_id": "3R01DA044206-02S1", "title": "Treating Young Adult Cannabis Use Disorder with Text Message-Delivered Peer Network Counseling", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8444, "first_name": "Shelley", "last_name": "Su", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-08-01", "end_date": "2024-05-31", "award_amount": 125036, "principal_investigator": { "id": 23054, "first_name": "J DOUGLAS", "last_name": "COATSWORTH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1560, "ror": "", "name": "UNIVERSITY OF TENNESSEE KNOXVILLE", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23055, "first_name": "Michael Jon", "last_name": "Mason", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1560, "ror": "", "name": "UNIVERSITY OF TENNESSEE KNOXVILLE", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "The novel coronavirus disease (COVID-19) pandemic of 2020 has disrupted normal daily functioning for people across the globe as governments have sought to limit community spread of the disease. Because the virus affects the respiratory tract, individuals with compromised lung function, such as those with COPD or lung disease associated with smoking or vaping may also be at elevated risk. Preliminary evidence suggests that smokers are at higher risk for severe COVID-19 illness and death (Guan et al., 2020). Public health messages urge people to quit smoking (Forster, 2020, and the World Health Organization recommends not smoking or using other substances to cope with stress during the pandemic (WHO, 2020). At the same time, studies indicate that individuals are likely in increase their smoking, alcohol intake and substance use during periods of high stress or traumatic events such as Hurricane Katrina or 911 (Flory et al., 2009). Given the urgency and stressful nature of this pandemic, there is a critical need for research investigating the influence of the pandemic on cannabis and tobacco smoking/vaping and other substance use. Directly building upon our NIDA-funded (1 R01 DA044206-01A1, Treating young adult cannabis use disorder with text messageddelivered Peer Network Counseling) RCT, we propose to follow a sample of 262 young adults from Tennessee (n = 139) and Colorado (n = 123) who screened positive for cannabis use disorder (CUD) and participated in a sub-study named the Cannabis Culture Study. Participants completed surveys about cannabis use behaviors, cannabis use motivations, and cannabis use attitudes between January 9 and February 3, 2020, immediately prior to increases in media attention and public health regulations regarding COVID-19. We propose to capitalize on this longitudinal natural experiment to understand the health risk effects of the COVID-19 pandemic on young adults with cannabis use disorder by assessing participants every 3 months for 24 months. Because the funded RCT will also be conducted during the naturally occurring socio-economic and personal changes in response to the COVID-19 pandemic, this sample of youth will provide a natural comparison group of how youths’ cannabis use attitudes and behaviors change in the context of COVID-19 but outside the experimental intervention activities. Our specific aims are: Aim1: Examine changes in cannabis, tobacco smoking/vaping, and other substance use as a function of the COVID-19 pandemic among young adults meeting criteria for CUD. Aim2: Examine mediated pathways by which COVID-19 pandemic affect changes in cannabis, tobacco smoking/vaping, and other substance use. Aim3: Examine whether the mediated pathways by which COVID-19 pandemic affect changes in cannabis, tobacco smoking/vaping, and other substance use are conditioned on sex and state residence.", "keywords": [ "2019-nCoV", "Address", "Affect", "Age", "Alcohol consumption", "Alcohol or Other Drugs use", "Anxiety", "Attention", "Attitude", "Behavior", "Belief", "COVID-19", "COVID-19 pandemic", "Cannabis", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "China", "Chronic Obstructive Airway Disease", "Colorado", "Communities", "Contracts", "Counseling", "Data", "Disease", "Disease Outbreaks", "Distress", "Family", "Funding", "Government", "Handwashing", "Health", "Hurricane", "Individual", "Intervention", "Knowledge", "Life", "Location", "Lung diseases", "Marijuana Smoking", "Measurement", "Mediating", "Mental Depression", "Motivation", "Names", "National Institute of Drug Abuse", "Natural experiment", "Nature", "Parents", "Participant", "Pathway interactions", "Pattern", "Peer Group", "Persons", "Population", "Public Health", "Recommendation", "Regulation", "Reporting", "Research", "Respiratory System", "Respiratory physiology", "Risk", "Sampling", "Schools", "Smoker", "Smoking", "Social Change", "Social Distance", "Social isolation", "Stress", "Substance Use Disorder", "Surveys", "Tennessee", "Testing", "Text", "Text Messaging", "Time", "Tobacco smoke", "Tobacco smoking behavior", "Urinalysis", "Viral Pneumonia", "Virus", "World Health Organization", "Youth", "addiction", "anxiety symptoms", "behavior change", "behavior influence", "comparison group", "coronavirus disease", "daily functioning", "design", "environmental change", "experience", "food insecurity", "high risk", "indexing", "insight", "marijuana use", "marijuana use disorder", "meetings", "neurodevelopment", "novel coronavirus", "pandemic disease", "peer", "peer networks", "psychiatric symptom", "psychologic", "residence", "response", "sex", "smoking cessation", "socioeconomics", "symptomatology", "traumatic event", "vaping", "young adult" ], "approved": true } }, { "type": "Grant", "id": "7259", "attributes": { "award_id": "3R01HL139671-02S1", "title": "SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear imaging in Minority Populations) COVID-19 Suppplement", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 10288, "first_name": "Patrice", "last_name": "Desvigne-Nickens", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-01", "end_date": "2022-08-31", "award_amount": 176033, "principal_investigator": { "id": 23058, "first_name": "MATHEW S", "last_name": "MAURER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23059, "first_name": "Frederick Lief", "last_name": "Ruberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 is a global pandemic that disproportionately affects minority older adults with cardiac disease and multiple chronic conditions. Densely populated urban centers with a high proportion of socioeconomically disadvantaged persons, including New York City (NYC) and Boston, are most impacted by COVID-19. SCAN- MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations, R01HL139671) is a NHLBI funded, prospective cohort study that enrolled 123 of a target 800 Black or Caribbean Hispanic participants over the age of 60 years with heart failure prior to the mandatory recruitment pause for the pandemic. The profile of the SCAN-MP participant matches those known to be at highest risk from COVID- 19. In this application, we propose to leverage the successful recruitment and retention techniques of the SCAN-MP infrastructure to advance our understanding of the prevalence of SARS CoV-2 infection and disentangle the demographic, social, and environmental factors known to be associated with infection. While mitigation is the primary public health strategy to address the spread of COVID-19, it may be particularly challenging for those with resource limitations or those who live in close physical proximity to others to comply with CDC recommendations, perhaps accounting for the observed increase in infection rates. Successful emergence from the pandemic will depend upon evidence of prior SARS CoV-2 infection in the population. Given that asymptomatic infection is common, serologic testing will likely play a critical role in the next phase of recovery. Serologic testing has been validated at Columbia University with a highly sensitive and specific, quantitative ELISA-based assay to detect antibodies to SARS-CoV-2 that we propose to leverage in this study. Our objectives are to (1) define the proportion of SCAN-MP participants with evidence of prior COVID- 19 infection by antibody testing, (2) determine the capacity of SCAN-MP participants to comply with CDC mitigation recommendations. We will then explore how infection rate and mitigation compliance interact with socio-economic factors such as income and living conditions, as well as measures of health literacy, trust/engagement in the health system, and perceived discrimination. We will explore whether the presence and/or titer of antibodies specific for SARS CoV-2 virus will be associated with future COVID-19 infection as well as adverse outcomes (hospitalizations and mortality) over a one-year time period. We are uniquely positioned to perform these studies quickly given our ability to recruit an urban, minority cohort with cardiac disease at high risk for COVID-19 morbidity/mortality, expertise in the performance of serologic testing for antibodies to SARS CoV-2, and established expertise in community engaged research. Successful completion of these Aims has the potential to inform implementation of mitigation strategies in high-risk populations and contribute important data useful for the resolution of the COVID-19 pandemic.", "keywords": [ "2019-nCoV", "Accounting", "Address", "Adherence", "Admission activity", "Affect", "African American", "African Caribbean", "Age", "Age-Years", "Amyloidosis", "Antibodies", "Antibody titer measurement", "Area", "Biochemical", "Biological Assay", "Boston", "COVID-19", "COVID-19 pandemic", "Cardiac", "Cardiovascular Diseases", "Caribbean Hispanic", "Cellular biology", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Chronic Kidney Failure", "Cities", "Clinical", "Cohort Studies", "Communities", "Congestive Heart Failure", "Data", "Demographic Factors", "Diabetes Mellitus", "Discrimination", "Economic Factors", "Education", "Elderly", "Enrollment", "Environmental Risk Factor", "Enzyme-Linked Immunosorbent Assay", "Funding", "Future", "Health", "Health system", "Heart Diseases", "Heart failure", "Hispanics", "Hospitalization", "Hypertension", "Income", "Individual", "Infection", "Infrastructure", "Left Ventricular Ejection Fraction", "Masks", "Measures", "Medical center", "Minority", "Morbidity - disease rate", "National Heart Lung and Blood Institute", "New York", "New York City", "Participant", "Pathology", "Patient Self-Report", "Patients", "Performance", "Persons", "Phase", "Play", "Population", "Positioning Attribute", "Prevalence", "Prospective cohort study", "Provider", "Public Health", "RNA Viruses", "Race", "Recommendation", "Recovery", "Research", "Resolution", "Resources", "Respiratory Failure", "Role", "Serologic tests", "Symptoms", "Techniques", "Testing", "Time", "Trust", "United States", "Universities", "Virus", "adverse outcome", "base", "cohort", "comorbidity", "disadvantaged population", "health literacy", "high risk", "high risk population", "infection rate", "male", "minority subjects", "mortality", "multiple chronic conditions", "nuclear imaging", "pandemic disease", "preservation", "prospective", "recruit", "screening", "social factors", "socioeconomic disadvantage", "socioeconomics", "urban dwelling" ], "approved": true } }, { "type": "Grant", "id": "7268", "attributes": { "award_id": "3R43ES030580-01S1", "title": "Extending a digital risk mitigation intervention for workers deployed in diverse post-flood environments to address unique SAR-CoV-2 virus infection exposure risks in construction workplaces", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Environmental Health Sciences (NIEHS)" ], "program_reference_codes": [], "program_officials": [ { "id": 21220, "first_name": "Kathy", "last_name": "Ahlmark", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-20", "end_date": "2021-08-31", "award_amount": 62559, "principal_investigator": { "id": 23061, "first_name": "Jeffery", "last_name": "McLaughlin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1563, "ror": "", "name": "RADIANT CREATIVE GROUP, LLC", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23062, "first_name": "William Brett", "last_name": "Perkison", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1563, "ror": "", "name": "RADIANT CREATIVE GROUP, LLC", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Flooding events continue to increase in both frequency and intensity. Workers involved in post-flood reconstruction work are at increased risk of adverse health effects due to respiratory exposures and other hazards. With the advent of the SARS-CoV-2 virus into the global community, these workers are even more at risk for severe illness. Proposed e-learning platform “Pocket Ark” provides training before flooding occurs, real-time decision support during a clean-up, and communications capabilities during and after cleanup to the workers involved. We propose to extend this project to include SARS-CoV-2 screening and education modules. Pocket Ark will be expanded to recognize early onset symptoms in workers and prevent its spread in the workplace as well as provide training regarding risk reduction in the workplace, and resources to locate health care resources. This platform addresses an important public health problem and uses a novel app-based e- learning platform to improve and enhance the cognitive understanding of flood-related health hazards within this vulnerable working population.", "keywords": [ "2019-nCoV", "Address", "Allergens", "Area", "Behavioral", "Businesses", "COVID-19", "Communicable Diseases", "Communication", "Communities", "Community Workers", "Competence", "Data Collection", "Development", "Disasters", "E-learning", "Ensure", "Environment", "Environmental Risk Factor", "Epidemic", "Equipment", "Event", "Exposure to", "Feedback", "Floods", "Food", "Frequencies", "Health", "Health Hazards", "Health Resources", "Health Status", "Healthcare", "Hispanics", "Housing", "Individual", "Infection", "Intervention", "Interview", "Irritants", "Knowledge", "Learning Module", "Measurement", "Measures", "Monitor", "Occupational Health", "Pattern", "Persons", "Phase", "Population", "Predisposition", "Prevalence", "Preventive measure", "Public Health", "Readiness", "Recurrence", "Reporting", "Research", "Resources", "Risk", "Risk Reduction", "Safety", "Sampling", "Sanitation", "Self Assessment", "Services", "Skin", "Symptoms", "Testing", "Time", "Training", "Training Programs", "Training Support", "Virus", "Virus Diseases", "Vulnerable Populations", "Work", "Workplace", "base", "climate change", "cloud based", "cognitive enhancement", "dashboard", "data visualization", "design", "digital", "early onset", "experience", "hazard", "high risk", "improved", "indexing", "infection risk", "innovation", "literate", "migration", "mobile application", "mobile computing", "novel", "pandemic disease", "phase 1 study", "prevent", "programs", "prototype", "reconstruction", "remediation", "respiratory", "risk mitigation", "screening", "skills", "skills training", "usability", "waterborne" ], "approved": true } }, { "type": "Grant", "id": "7271", "attributes": { "award_id": "3R01DK123749-01S1", "title": "Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [ { "id": 20610, "first_name": "Peter J", "last_name": "Perrin", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-09-01", "end_date": "2021-08-31", "award_amount": 787826, "principal_investigator": { "id": 23064, "first_name": "Jeremiah James", "last_name": "Faith", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23065, "first_name": "Saurabh", "last_name": "Mehandru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "In approximately 6 months, the Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has resulted in >6 million cases and led to >350K deaths worldwide, with over 100K of these deaths in the USA alone. Although the major pathologies leading to these deaths are cardiovascular and pulmonary in nature, COVID-19 is a multi-system disease and gastrointestinal (GI) symptoms are frequently reported. While animal studies and in-vitro experiments demonstrate that enterocytes can be infected by SARS-CoV-2, analyses of the GI tract in humans have been limited to viral RNA detection in feces or suggestions of enteric inflammation as measured by elevated levels of fecal calprotectin in a subset of patients. Being at the forefront of COVID-19 cases in New York City, we have recruited a cohort of >60 individuals. With a strong collaborative infra-structure supported by the parent R01 grant focusing on host-viral (HIV-1 associated) interactions in the GI tract, we are well-poised for detailed analyses of intestinal tissues in COVID-19 patients. Specifically, as evidenced in the submitted application, we have already generated a strong body of data, demonstrating for the first time, human enterocyte infection by SARS-CoV-2 that is in some cases associated with evidence of intestinal inflammation as measured by fecal calprotectin and numerous fecal cytokines. We are in the process of determining how these inflammatory responses modulate SARS-CoV-2 specific immune responses as measured by fecal IgA. The supplementary funds as requested will allow us to continue with the analyses of specimens that are already banked and will enable further recruitment of patients with active and convalescent COVID-19 disease. With the proposed studies, we aim to a) further characterize infection of GI tissues; b) determine viral persistence in the gut during convalescence; and c) determine the generation and evolution of inflammatory and antigen-specific mucosal immune responses. Altogether, through further development and analyses of this unique cohort, we aim to provide important insights into the role played by the GI tract in COVID-19 pathogenesis and transmission.", "keywords": [ "16S ribosomal RNA sequencing", "2019-nCoV", "Acute", "Acute Disease", "Admission activity", "Affect", "Animals", "Antigens", "Archives", "Biological Assay", "Biopsy", "Biopsy Specimen", "Brush Border", "COVID-19", "COVID-19 pandemic", "Cardiovascular system", "Cessation of life", "Cities", "Clinical", "Collaborations", "Consent", "Contact Tracing", "Convalescence", "Culture Techniques", "Cytometry", "Data", "Detection", "Development", "Diarrhea", "Disease", "Disease Outbreaks", "Electron Microscopy", "Enteral", "Enterocytes", "Epidemiology", "Epithelial", "Epithelium", "Evolution", "Feces", "Frequencies", "Funding", "Gastrointestinal tract structure", "Generations", "Genomics", "Grant", "HIV-1", "Human", "Immune", "Immune response", "Immunofluorescence Immunologic", "Immunoglobulin A", "Immunoglobulins", "Immunologics", "Immunologist", "Immunology", "In Vitro", "Individual", "Infection", "Inflammation", "Inflammatory", "Inflammatory Response", "Infrastructure", "Institutional Review Boards", "Intestines", "Investigation", "Laboratories", "Large Intestine", "Leukocyte L1 Antigen Complex", "Literature", "Lower Gastrointestinal Tract", "Lung", "Measures", "Microscopy", "Mucosal Immune Responses", "Mucous Membrane", "National Institute of Diabetes and Digestive and Kidney Diseases", "Nature", "Nausea and Vomiting", "New York", "New York City", "Organ", "Parents", "Pathogenesis", "Pathology", "Patient Recruitments", "Patients", "Peptidyl-Dipeptidase A", "Peripheral Blood Mononuclear Cell", "Phase", "Play", "Process", "Proteins", "Publishing", "Reporting", "Research Personnel", "Respiratory Failure", "Respiratory Signs and Symptoms", "Retrieval", "Role", "Running", "Sampling", "Serologic tests", "Serological", "Serum", "Site", "Small Intestines", "Specimen", "Suggestion", "Symptoms", "System", "Time", "Tissues", "Viral", "Virion", "Virus", "base", "cohort", "cytokine", "enteric infection", "experience", "experimental study", "gastrointestinal", "gastrointestinal infection", "gastrointestinal symptom", "gut microbiota", "inflammatory disease of the intestine", "innovation", "insight", "interest", "medical schools", "metagenomic sequencing", "microbiome", "nonhuman primate", "novel", "particle", "patient subsets", "recruit", "research study", "response", "stool sample", "transmission process", "viral RNA", "virology" ], "approved": true } }, { "type": "Grant", "id": "7274", "attributes": { "award_id": "3U24AI118644-05S1", "title": "Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disesase", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 7248, "first_name": "Wendy F.", "last_name": "Davidson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-06-24", "end_date": "2021-05-31", "award_amount": 369849, "principal_investigator": { "id": 23068, "first_name": "Maria CECILIA", "last_name": "BERIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23069, "first_name": "MIRIAM", "last_name": "MERAD", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 625, "ror": "https://ror.org/04a9tmd77", "name": "Icahn School of Medicine at Mount Sinai", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "of the funded parent award The human immune monitoring core (HIMC) at the Icahn School of Medicine at Mount Sinai (ISMMS) is a novel research center spearheaded by Dr. Merad and colleagues in 2011 and funded by the Dean of ISMMS to promote the development of novel immune profiling tools to help identify novel biomarkers of diagnosis, prognosis, and response to therapy. One of the main challenges to studies of the immune system has been the limited availability of human samples reducing our ability to perform in-depth comprehensive analysis of immune functions in patients. The goal of this application is to develop novel immune profiling tools and functional assays to identify novel targets and novel biomarker of diseases and response to therapy in two clinical areas: food allergy and IBD. The initial focus on these two disease areas reflects the extraordinary ISMMS clinical recruitment of allergic and IBD patients, yet any technological development obtained in this grant will be applied to other inflammatory disease such as atherosclerosis, and skin inflammatory disease including psoriasis and atopic dermatitis for which ISMMS is also a referral center. Food allergy is a common disease of childhood for which there are no treatment or prevention strategies. The Pediatric Allergy and Immunology division at ISMMS has built one of the most active clinical research programs in food allergy in the country. Mechanistic insights have lagged behind clinical gains due to the difficulty of profiling allergen-specific cells, particularly given the challenge of small blood volumes available from pediatric patients. Thus one of the goals of this proposal is to develop novel immune and genomics tools to identify and profile allergen-specific T cells at the single-cell level. The ISMMS Inflammatory Bowel Disease (IBD) Center is unique in its close, integrated collaborations between world-leaders in clinical, genetic, microbiome and immunology-based IBD research. While efforts to explore immune regulators causative of disease has focused on exploiting GWAS data and exploring systemic dysregulation, little effort has been devoted to comprehend the nature of the immune dysregulation that occurs at the tissue site mainly due to limited availability of gastrointestinal tissue. Thus Aim 2 of this project proposes to leverage the extraordinary tissue samples obtained by the ISMMS IBD Center to develop novel immunological assays to profile immune cell compartments that infiltrate and contribute to IBD lesions in early diagnosed patients and at different time after initiation of immunodulatory agents.", "keywords": [ "2019-nCoV", "Address", "Allergens", "Allergic", "Antigens", "Area", "Atherosclerosis", "Atopic Dermatitis", "Award", "Biological Assay", "Biological Markers", "Biological Response Modifiers", "Blood Volume", "CD8-Positive T-Lymphocytes", "COVID-19", "Cell Compartmentation", "Cells", "Child", "Childhood", "Clinical", "Clinical Research", "Cohort Studies", "Collaborations", "Country", "Data", "Development", "Diagnosis", "Disease", "Disease Progression", "Early Diagnosis", "Food", "Food Hypersensitivity", "Funding", "Goals", "Grant", "Human", "Hypersensitivity", "Immune", "Immune System Diseases", "Immune response", "Immune system", "Immunologic Monitoring", "Immunology", "Immunology procedure", "Immunophenotyping", "Infection", "Inflammatory", "Inflammatory Bowel Diseases", "Intestines", "Lesion", "Medical Genetics", "Monitoring Clinical Trials", "Nature", "Parents", "Patients", "Phenotype", "Population", "Prevention strategy", "Proteins", "Protocols documentation", "Psoriasis", "Research", "Sampling", "Site", "Skin", "Structure", "T-Lymphocyte", "Time", "Tissue Sample", "Tissues", "United States National Institutes of Health", "Whole Blood", "Work", "base", "biomedical referral center", "gastrointestinal", "genome wide association study", "genomic tools", "immune function", "immunoregulation", "insight", "medical schools", "microbiome", "novel", "novel marker", "outcome forecast", "pediatric patients", "programs", "recruit", "response", "targeted biomarker", "tool", "treatment strategy" ], "approved": true } }, { "type": "Grant", "id": "7275", "attributes": { "award_id": "3R34DA050268-01S2", "title": "4/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 10219, "first_name": "Vani", "last_name": "Pariyadath", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-30", "end_date": "2021-03-31", "award_amount": 169281, "principal_investigator": { "id": 23070, "first_name": "STEPHANIE L", "last_name": "MERHAR", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23071, "first_name": "JENNIFER J.", "last_name": "VANNEST", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 897, "ror": "", "name": "CINCINNATI CHILDRENS HOSP MED CTR", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic has affected the mental and physical health of children and their parents. The pandemic has also affected the ability to conduct in-person research at most institutions across the United States. However, recent technological advances may allow many in-person assessments to transition to virtual formats. There is an urgent need to develop virtual versions of currently used assessments of the home environment and parent-child interactions, and to concurrently study the effect of the COVID-19 pandemic on family relationships. The proposed project seeks to address this urgent need by building upon ongoing research efforts among three sites from the NIH HEALthy Brains and Cognitive Development (HBCD) study: Arkansas Children’s Research Institute, Cincinnati Children’s Hospital, and the University of North Carolina at Chapel Hill. We will develop and test a virtual version of the HOME Inventory in 90 mothers with infants between 6-18 months of age. We will validate this virtual version by performing in-person HOME Inventory assessments in 45 of these dyads. In all participants, we will use standard questionnaires to assess COVID-19 exposure and impact. Finally, we will examine associations between regional and temporal variations in COVID-19 exposure and impact and dimensions of the HOME Inventory. The results of this study will be used to finalize the development of a virtual HOME Inventory protocol that can be widely used in future studies, including the HBCD Phase II study.", "keywords": [ "Address", "Adult", "Affect", "Age-Months", "Anxiety", "Arkansas", "Behavior", "Brain", "COVID-19", "COVID-19 pandemic", "Child", "Child Development", "Child Health", "Child Rearing", "Cognitive", "Cohort Studies", "Development", "Dimensions", "Environment", "Equipment", "Equipment and supply inventories", "Family", "Family Relationship", "Future", "Geography", "Home environment", "Individual", "Infant", "Infection", "Institution", "Manuals", "Measurement", "Measures", "Mental Health", "Mothers", "North Carolina", "Parent-Child Relations", "Parents", "Participant", "Pediatric Hospitals", "Perinatal", "Persons", "Phase", "Protocols documentation", "Psychometrics", "Questionnaires", "Research", "Research Institute", "Safety", "Schools", "Site", "Stress", "Surveys", "Testing", "Time", "Training", "Transcend", "Uncertainty", "United States", "United States National Institutes of Health", "Universities", "Validation", "Variant", "Visit", "cognitive development", "cost", "experience", "innovation", "learning materials", "pandemic disease", "phase 1 study", "phase 2 study", "physical conditioning", "social", "virtual" ], "approved": true } }, { "type": "Grant", "id": "7277", "attributes": { "award_id": "3R43MD014923-01S1", "title": "Fourth Trimester-A Web-based Tool For Postpartum Care To Address The needs Of Underserved Women", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 6121, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2019-09-23", "end_date": "2021-03-31", "award_amount": 168215, "principal_investigator": { "id": 23072, "first_name": "Lisa D", "last_name": "Marceau", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1564, "ror": "", "name": "ORANGE SQUARE DESIGN, INC.", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23073, "first_name": "Kristine", "last_name": "Merz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1564, "ror": "", "name": "ORANGE SQUARE DESIGN, INC.", "address": "", "city": "", "state": "RI", "zip": "", "country": "United States", "approved": true }, "abstract": "The postpartum period is a critical time, and more than half of all maternal deaths occur postpartum. Black women are 3-4 times more likely than white women to experience maternal mortality. In the US, 1 in 4 women do not have a timely postpartum visit, and adherence is even lower for women on Medicaid managed care plans. Our Parent Grant (R43MD014923) was funded to develop a program that educates and supports mothers in the ‘fourth trimester’, to address the physical, cultural, and knowledge barriers to quality postpartum care. The COVID-19 crisis presents novel health and economic challenges for this vulnerable population. Because of the myriad challenges COVID-19 presents, and the ways in which it will transform postpartum care, it is our responsibility to revise the scope of our project to address COVID-19 in our research and to add features to the tool we are building to address immediate concerns and needs related to this crisis. The challenges of the current pandemic will have a lasting impact for minority and economically at-risk populations because fundamental health disparities persist, further inhibiting already limited access to timely and appropriate care. Racial and ethnic minority women are more likely to have gaps in health insurance coverage, a situation further complicated by the higher proportion of unemployment during the pandemic and ensuing economic crisis. In addition, there are over 30 million small businesses in the US hard hit by this dual crisis – many of which are in the healthcare sector. They are critical for providing services to this vulnerable population and are most at risk of losing their businesses during times of economic instability. Research focused on the concerns, needs, and health of underserved women, and the development of digital tools to reduce gaps in care which specifically address barriers exacerbated by COVID-19, are essential to protect the health of mothers and their babies. Our strong relationships with community groups and healthcare providers, and support of the RI Department of Health, Brown University, Goldman Sachs 10KSB, and Social Enterprise Greenhouse, enable us to immediately begin to broaden our scope to learn more about the COVID-19 impact on underserved women and the provider community that supports them. We propose to expand our scope to: • conduct qualitative research activities to obtain specific input regarding the COVID-19 pandemic and economic crisis from pregnant and recently postpartum women and conduct interviews with the healthcare support network during the COVID-19 crisis; • expand the scope of the prototype to include specific content responding to feedback on needs related to COVID-19; and • systematically assess the impact of the prototype on key health outcome measures through a modest pilot study. We will focus on resilience as a key outcome and will measure related factors such as depression, anxiety, healthcare utilization, and postpartum experiences. These activities will provide a baseline for longitudinal data collection in Phase II; result in an even stronger program for postpartum care; and provide valuable data for future interventions and policies for this population.", "keywords": [ "Address", "American College of Obstetricians and Gynecologists", "Anxiety", "Businesses", "COVID-19", "COVID-19 pandemic", "Caring", "Child", "Child Support", "Clinical", "Clinical Research", "Communities", "Data", "Data Collection", "Development", "Economics", "Ethnic Origin", "Evidence based practice", "Family", "Family member", "Feedback", "Fright", "Funding", "Future", "Goals", "Health", "Health Care Sector", "Health Insurance", "Health Personnel", "Healthcare", "Income", "Insurance Coverage", "Intervention", "Interview", "Knowledge", "Learning", "Letters", "Managed Care Programs", "Maternal Mortality", "Maternal and Child Health", "Measures", "Medicaid", "Mental Depression", "Minority", "Mothers", "Newborn Infant", "Outcome", "Outcome Measure", "Participant", "Personal Satisfaction", "Phase", "Pilot Projects", "Policies", "Population", "Population Policies", "Populations at Risk", "Postpartum Period", "Postpartum Programs", "Postpartum Women", "Pregnant Women", "Provider", "Psyche structure", "Public Health Schools", "Qualitative Research", "Race", "Reaction", "Research", "Research Activity", "Research Methodology", "Resources", "Rhode Island", "Risk", "Self Care", "Services", "Stress", "Surveys", "Telephone", "Third Pregnancy Trimester", "Time", "Uncertainty", "Unemployment", "United States", "Universities", "Vulnerable Populations", "Woman", "Women&apos", "s Group", "Women&apos", "s Health", "Wood material", "Work", "base", "digital", "ethnic minority population", "experience", "fourth trimester", "health care service utilization", "health disparity", "health economics", "health of the mother", "novel", "pandemic disease", "parent grant", "postpartum care", "preference", "pregnant", "programs", "prototype", "racial minority", "resilience", "social", "stressor", "support network", "tool", "visit adherence", "web-based tool", "welfare" ], "approved": true } }, { "type": "Grant", "id": "7281", "attributes": { "award_id": "3U24HL135691-03S3", "title": "MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C Program", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 23077, "first_name": "Charlene A.", "last_name": "Schramm", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2020-08-04", "end_date": "2020-12-31", "award_amount": 4327649, "principal_investigator": { "id": 23078, "first_name": "Julie", "last_name": "Miller", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1566, "ror": "", "name": "NEW ENGLAND RESEARCH INSTITUTES, INC.", "address": "", "city": "", "state": "DE", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23079, "first_name": "Felicia Lynn", "last_name": "Trachtenberg", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 1566, "ror": "", "name": "NEW ENGLAND RESEARCH INSTITUTES, INC.", "address": "", "city": "", "state": "DE", "zip": "", "country": "United States", "approved": true }, "abstract": "To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of MIS-C. The Program will have several components including a MIS-C Cohort Study, adaptive design trials, long-term follow-up and a robust cloud-based data platform. The PHN DCC will serve to coordinate some of the components of the Program. The Specific Aims of the DCC are as follows: AIM 1: MANAGE CORE PROGRAM OPERATIONS AIM 2: MANAGE MIS-C COHORT STUDY DEVELOPMENT, LAUNCH, AND DISSEMINATION OF RESULTS AIM 3: PROVIDE SUPPORT SERVICES TO PROGRAM COMPONENTS", "keywords": [ "2019-nCoV", "Address", "Agreement", "Budgets", "COVID-19", "Childhood", "Clinical Trials Data Monitoring Committees", "Cohort Studies", "Data", "Data Coordinating Center", "Development", "Electrocardiogram", "Goals", "Heart", "Individual", "Information Dissemination", "Infrastructure", "Knowledge", "Laboratories", "Leadership", "Link", "Logistics", "Longterm Follow-up", "Magnetic Resonance Imaging", "Maintenance", "Methods", "Monitor", "National Heart Lung and Blood Institute", "Natural History", "Outcome", "Participant", "Periodicity", "Phenotype", "Progress Reports", "Protocols documentation", "Research", "Review Committee", "Running", "Services", "Site", "System", "TimeLine", "United States National Institutes of Health", "Update", "Work", "cloud based", "data integration", "electronic data capture system", "insurance claims", "operation", "payment", "programs", "recruit", "social media", "symposium", "trial design", "web site", "webinar" ], "approved": true } }, { "type": "Grant", "id": "7282", "attributes": { "award_id": "3UH3DA044822-04S1", "title": "Learning from the COVID-19 pandemic to improve emergency management planning for harm reduction services in rural Ohio", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Drug Abuse (NIDA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20583, "first_name": "KEISHER S", "last_name": "Highsmith", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2017-08-15", "end_date": "2022-07-31", "award_amount": 138423, "principal_investigator": { "id": 23080, "first_name": "VIVIAN F.", "last_name": "GO", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23081, "first_name": "WILLIAM C", "last_name": "MILLER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "COVID-19 has been devastating in many areas of the United States. Both the disease itself and the necessary mitigation measures have affected local communities. Local health departments have struggled to identify ways to continue to serve their communities. One population that has been affected in multiple ways is people who inject drugs (PWID). In many rural areas, harm reduction services have been closed because of the response to COVID-19, isolating many PWID. Some health departments have noted the absence of a clear emergency response plan to continue serving the vulnerable PWID population. Building on our relationships that we have established in our UG3/UH3 Rural Opioid Initiative project, referred to as the Ohio Opioid Project (OHOP), we will assess the impact of the COVID-19 pandemic on local stakeholders and PWID in southern Ohio. We will then use this information to develop an emergency management plan for two local health departments that provide the only syringe service programs in the area. This plan will form the basis of a generalizable approach that can be used elsewhere in rural areas of the U.S. The aims for this supplement are to: Aim 1) Explore the impact of COVID-19 on PWID and harm reduction services to identify strengths and gaps in emergency preparedness in Scioto and Gallia Counties (Step 1, PHEPARC). Aim 2) Assess the impact of COVID-19 on overdose and infectious diseases among PWID (Step 1, PHEPARC) Aim 3) Develop an emergency management plan for harm reduction and treatment services for use in Ohio and other states. In Aim 1, we will assess provider preparation, unanticipated and anticipated challenges, and the impact on services in the immediate aftermath of the pandemic. We will conduct 30 in-depth interviews with PWID and 30 in-depth interviews with substance use providers, first responders, and state and local emergency response officials. In Aim 2, we will explore PWID’s experiences with stigma, injection networks, overdose, syringe access, and access to care for MOUD and other health care through our respondent-driven sampling (RDS) survey. In Aim 3, we will draw from Aim 1 and 2 findings and work closely with the Ohio governmental agencies, local health departments, and our community advisory board to develop a flexible emergency response plan that can address the unique needs of rural counties. The plan will include a decision structure, communication plan, and detailed guidelines for substance use providers to mitigate the impact of future crises. Upon completion of this supplement, we will have a clear understanding of the impact of the COVID-19 pandemic on PWID and harm reduction support in rural Ohio. And we will provide a strategy to mitigate the impact of future crises on the rural PWID population in the future.", "keywords": [ "2019-nCoV", "Accident and Emergency department", "Address", "Advocate", "Affect", "Alcohol or Other Drugs use", "Anxiety", "Area", "Back", "COVID-19", "COVID-19 pandemic", "Client", "Communicable Diseases", "Communication", "Communities", "County", "Development", "Discrimination", "Disease", "Drug usage", "Drug user", "Economics", "Emergency Situation", "Emergency response", "Ensure", "Feeling", "Fright", "Future", "Government Agencies", "Guidelines", "Harm Reduction", "Health", "Health Personnel", "Health Services Accessibility", "Healthcare", "Healthcare Systems", "Home environment", "Infrastructure", "Injecting drug user", "Injections", "Intervention", "Interview", "Learning", "Left", "Measures", "Modeling", "Naloxone", "Needle-Exchange Programs", "Ohio", "Opioid", "Overdose", "Pharmaceutical Preparations", "Population", "Preparation", "Primary Health Care", "Provider", "Public Health", "Readiness", "Recovery", "Relapse", "Resources", "Respondent", "Risk", "Rural", "Sampling", "Services", "Social Distance", "Social isolation", "Stretching", "Structure", "Surveys", "Syringes", "Telemedicine", "Time", "Travel", "United States", "Vulnerable Populations", "Work", "addiction", "disorder risk", "experience", "first responder", "flexibility", "improved", "novel coronavirus", "opioid epidemic", "opioid use", "opioid use disorder", "pandemic disease", "prescription opioid", "programs", "public health emergency", "response", "rural area", "rural counties", "rural planning", "service delivery", "social", "social stigma", "treatment services" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1397, "count": 13961 } } }