Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=end_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=end_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=end_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=end_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=end_date" }, "data": [ { "type": "Grant", "id": "15448", "attributes": { "award_id": "5U18HS029911-02", "title": "Advancing Long COVID Care in our Community through Access, Equity, and Collaboration", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 31564, "first_name": "Latrice", "last_name": "Vinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 931222, "principal_investigator": { "id": 28180, "first_name": "Abby Ling-Lee", "last_name": "Cheng", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28181, "first_name": "Jonas", "last_name": "Marschall", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28182, "first_name": "Amy", "last_name": "McQueen", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 827, "ror": "", "name": "WASHINGTON UNIVERSITY", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "Long COVID manifests differently for each person and can contribute to disabling, life-changing symptoms such as extreme fatigue, cognitive dysfunction, breathing difficulty, and autonomic dysfunction in people across the age spectrum, including in people who were previously healthy and in people who had minimal or no symptoms associated with acute COVID-19 infection. Multidisciplinary Long COVID clinics were a mainstay of patient support during the initial phases of the COVID-19 pandemic, but as the pandemic is shifting to a new phase, care models must also evolve in order to meet the complex medical, rehabilitative, and social needs of the continually growing number of people who are affected by Long COVID. The purpose of this project is to transform an existing, university-based Long COVID clinic into a broader Long COVID community network in order to expand equitable access to care, improve the patient care experience, and support primary care practitioners. This project will invest in two particularly underserved populations: 1) the Black community in St. Louis, Missouri, which is a historically mistreated population who continues to be marginalized by previously sanctioned segregation practices; and 2) rural communities across Missouri. Aim 1 is to expand equitable access to Long COVID care by: 1) building clinical capacity, and 2) removing structural barriers to care. This will be accomplished by: 1) hiring additional clinicians for the Long COVID Clinic in order to reduce wait times; and 2) removing patient requirements for clinic evaluation that disproportionately affect underserved populations. Aim 2 is to improve the Long COVID care experience by: 1) streamlining care that crosses multiple disciplines and physical care sites, and 2) supporting patients’ social needs. This will be accomplished by: 1) supporting a clinical case manager to directly assist patients with coordinating medical care and connecting with community resources, and 2) iteratively assessing and addressing referral challenges between clinics. Aim 3 is to support primary care teams as they care for patients with Long COVID by co-creating: 1) educational resources for PCPs, and 2) streamlined communication and referral pathways between PCPs and specialty clinicians. This will be accomplished by engaging multiple key stakeholders to: 1) develop multi- modality educational materials related to Long COVID patient assessment and management; 2) disseminate materials via culturally and logistically preferred approaches (including via established, trusted community intermediaries and via an established ECHO (Enhanced for Community Healthcare Outcomes) virtual educational infrastructure); and 3) refine existing handoff processes to minimize the administrative workload on PCP teams and facilitate their ability to meet patients’ needs. Continuous stakeholder input, comprehensive data tracking, and iterative needs assessments using mixed methods approaches will facilitate ongoing project evaluation and adaptation in order to respond to the community’s evolving needs.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15457", "attributes": { "award_id": "5U18HS029905-02", "title": "Improving Access to Multidisciplinary Care for patients with long COVID", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 28197, "first_name": "Leeann", "last_name": "Comfort", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 999195, "principal_investigator": { "id": 28198, "first_name": "Jessica Anne", "last_name": "Bender", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28199, "first_name": "Janna L", "last_name": "Friedly", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28200, "first_name": "Nikki", "last_name": "Gentile", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "The proposed project seeks to expand the existing UW multidisciplinary long COVID clinic (the Post COVID Rehabilitation and Recovery clinic) to improve access and coordination of care for patients with long COVID. This project will allow the team to improve care delivery for all patients, but will emphasize improving access to multidisciplinary care for underserved patients including patients in rural communities, Alaska, and in Latinx, Native American, and SE Asian communities. With additional funding, we will make an enormous impact on a large region throughout WWAMI, focusing initially on Washington and Alaska, and Idaho, Montana, Wyoming in the later years. The aims of this proposed project include Aim 1: Improve clinical care delivery and expand access to the UW PCRRC. The goal of this aim is to improve access and care delivery for patients from Washington and Alaska that are referred to the Post-COVID Rehabilitation and Recovery clinic. The key areas that we will be expanding in this project include: 1) coordination of care; 2) behavioral health support; 3) vocational services; and 4) electronic consults. Aim 2: Engage underserved communities to enhance long COVID education and connection to local resources. The overall goal of our community engagement activities will be to foster authentic longitudinal relationships, promote ongoing collaborations and address the needs of community members. We will accomplish this by: 1) forming a community advisory board to guide our engagement activities; 2) producing publicly accessible educational webinars (community conversations) addressing COVID and long COVID; 3) producing culturally responsive patient education materials on long COVID in English, Spanish, and SE Asian languages; and 4) participating in community events including town hall meetings, community health fairs, pop-up vaccination events to share information about the UW long COVID clinic and long COVID. Aim 3: Improve patient access in the WWAMI region by training a network of clinicians specializing in long COVID care. In this aim, we will provide ongoing education and support to community PCPs, psychologists, and physical therapists with a focus on providers in under-resourced areas across the WWAMI region, including rural areas. We will accomplish this by: 1) In partnership with the Washington State DOH, we will create an advanced training certificate program for long COVID. 2) We will conduct monthly interactive case-based webinars. 3) We will also identify local physician and physical therapy leads who can be trained to be local experts in the care of patients with long COVID and are a part of our extended UW PCRRC network. 4) We will hold weekly virtual office hours that are pre-specified with a scheduling system to allow community providers to discuss cases and ask questions that will help them with their own management of patients with long COVID.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15460", "attributes": { "award_id": "5U18HS029930-02", "title": "Long COVID Care Resources and Education to Advance Community Health (REACH)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 28323, "first_name": "Marian", "last_name": "James", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 988527, "principal_investigator": { "id": 28324, "first_name": "Hector Fabio", "last_name": "Bonilla", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 28325, "first_name": "Linda N", "last_name": "Geng", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28326, "first_name": "UPINDER", "last_name": "SINGH", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 266, "ror": "https://ror.org/00f54p054", "name": "Stanford University", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Long COVID affects millions of people in the U.S. and has disproportionately impacted vulnerable populations including low-income persons and communities of color who often face barriers to healthcare access. As trusted, accessible providers, federally-qualified healthcare centers (FQHCs) are well-positioned to help mitigate inequities by providing access to Long COVID care in their medically underserved communities. We propose that a care model, Long COVID Care Resources and Education to Advance Community Health (REACH) where a centrally-coordinated, multidisciplinary Long COVID hub program that supports and partners with networks of safety-net FQHCs in the community will help expand and improve the care of vulnerable patient populations suffering from Long COVID. The Stanford Long COVID hub program is a team-based multidisciplinary clinical and research program rooted in a primary care-specialty care partnership and, together with key community partners including Community Health Center Network and San Mateo Medical Center and others, our goal is to extend the reach of this program and expand access for vulnerable patients with Long COVID through the following specific aims: AIM 1: Improve community awareness and education on Long COVID for patients and clinicians. AIM 2: Support primary care providers in partner safety-net FQHCs by creating a collaborative learning community with peer-to-peer asynchronous and real-time consultation. AIM 3: Improve Long COVID care referral coordination and access at the Stanford hub clinic. Our approach is to build upon the evidence-based and well-established Chronic Care Model (CCM) with innovative components that are adaptive and responsive to the rapidly changing landscape of Long COVID care. We will implement the tiered educational outreach and peer-to-peer primary care support strategies across partnering FQHCs with synergistic expertise from our colleagues at the Evaluation Sciences Unit, Office of Community Engagement, and Center for Continuing Medical Education. We will utilize a stepped wedge design and evaluate the model with a formative and summative mixed-methods approach guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to assess overall project reach and impact and adapt strategies throughout the REACH project duration. As part of the cooperative, we will collaborate with AHRQ and other recipients in the Learning Community to share, incorporate, and disseminate learnings in a collective effort to support the primary care community in Long COVID education and management. Overall the goals are to expand access to comprehensive, coordinated, and person-centered care for vulnerable patients with Long COVID.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15475", "attributes": { "award_id": "5U18HS029943-02", "title": "Novel Statewide Response to Post-COVID Care Delivery", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 31564, "first_name": "Latrice", "last_name": "Vinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 976981, "principal_investigator": { "id": 28235, "first_name": "Sarah E", "last_name": "Jolley", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 22611, "first_name": "DONALD E", "last_name": "NEASE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "Long COVID is an important public health threat impacting millions of individuals including 600,000 Coloradans. Current Long COVID care is highly fragmented, variable in nature, and in constant evolution. Creating a novel approach to practice support with continued education and streamlining care for high Long COVID will improve care integration and patient experience. We will implement the Colorado Multidisciplinary Translation Network (CO-MTN) comprised of integrated, multidisciplinary Long COVID care clinics and primary care clinics working together in a tiered care delivery pathway. CO-MTN creates a bidirectional translational care network for integrating expertise, education, referrals, and care between MDCs, PCPs and teams, and their patients. CO-MTN includes 1) the State of Colorado-supported Long COVID Community of Practice comprised of three geographically distributed MDCs, 2) a state-wide practice-based research network representing 280 primary care practices, known as the State Networks of Colorado Ambulatory Practices & Partners, and 3) a proven tele-education system used to provide health care practitioners specialty training, Extension for Community Healthcare Outcomes. CO-MTN includes implementation strategies to support the tiered care pathway including training and learning communities to support PCPs with improved knowledge and capacity and provide exceptional care for Colorado Long COVID patients, and practice facilitation to effectively implement the PCP care in their practice and coordinate with the MDCs. CO-MTN will help Long COVID patients in Colorado and have the potential for scaling to other states. To guide implementation and evaluation, we will utilize the Exploration, Preparation, Implementation and Sustainment dissemination and implementation framework. We will measure sustainment as continued involvement in the network during the final six months of the project period. Using qualitative, quantitative, and mixed methods, we will evaluate the Reach and Effectiveness for patients, and the Adoption, Implementation and Maintenance of the implementation strategies using the RE-AIM framework based on the following aims: Aim 1: Implement an integrated, tiered care delivery pathway with facilitated implementation support via CO-MTN and measure its effect on 1) Reach of Long COVID care to Colorado patients, specifically those described as underserved, and 2) Effectiveness on reducing Long COVID symptom burden and severity for patients engaged. Aim 2: Determine the effect of CO-MTN on 1) Adoption of the CO-MTN tiered care delivery model by primary care clinics and PCPs within these clinics, 2) Implementation of the tiered care pathway, and 3) Maintenance of the tiered care pathway key components past the active project period. Our team is comprised of national experts in Long COIVD care, practice-based research, and implementation science. Together, our multidisciplinary team will partner through CO-MTN structures and support to deliver high quality Long COVID care.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15480", "attributes": { "award_id": "5U01IP001171-02", "title": "RFA-IP-22-001 - Burden and sequelae of influenza, SARS-CoV-2 and other respiratory viruses associated Severe Acute Respiratory Infections among Indian adult population aged 18-60yrs", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Center for Immunization and Respiratory Diseases (NCIRD)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2023-09-30", "end_date": "2028-09-29", "award_amount": 750000, "principal_investigator": { "id": 28245, "first_name": "Anand", "last_name": "Krishnan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2084, "ror": "", "name": "ALL-INDIA INSTITUTE OF MEDICAL SCIENCES", "address": "", "city": "", "state": "", "zip": "", "country": "INDIA", "approved": true }, "abstract": "As a logical extension of the work done by the team at the All India Institute of Medical Science, New Delhi, this work will expand to include more geographically diverse sites and address adults who have not been adequately studied but who due to their productivity can dis-appropriately contribute to the overall economic burden. The proposal intends to execute a series of inter-related activities to support evidence-based policy development to address Influenza and SARSCo-V2 infection in working adult population of India. The specific objectives are to estimate the incidence and treatment cost of Influenza and SARS-CoV-2 associated Severe Acute Respiratory Infections (SARI) among adults aged 18-60 years and characterize the detected viruses; to estimate the incidence of short and long-term sequelae of Influenza and SARS-CoV-2 associated SARI and risk of re-infection; to assess vaccine hesitancy and uptake among health care workers and estimate the effectiveness of influenza and COVID-19 vaccines against serious illness and finally, conduct capacity building initiatives for health professionals and advocate for public health approach for prevention and control of influenza and COVID-19 disease in India among key stakeholders. This will be done by setting up Indian National SARI Platform for Influenza and other Respiratory Pathogens (INSPIRES) a multi-centric network of public tertiary hospitals with three components – hospital-based SARI Registry with a cohort of Influenza or COVID-19 patients with a linked community site and a cohort of healthcare workers. The platform will consist of geographically spread 10-12 medical colleges which routinely admit and manage SARI cases. The patients with severe acute respiratory infection (SARI) admitted and testing positive for identified pathogens i.e., influenza and SARS CoV-2. The community-based SARI surveillance to be conducted in the catchment area of the hospitals will estimate SARI incidence rates. Combining the two will provide agent- specific SARI rates for each participating site. A cohort of influenza and SARS CoV-2 positive patients identified above will be followed for two years after enrolment to look at pulmonary, cardiac, cognition, functional status and quality of life parameters. A cohort of health care workers in the study hospitals will be followed up for the duration of the study. After a baseline assessment of their vaccine uptake and hesitancy, they will be sensitized to the need for vaccination and offered free vaccines (both influenza and COVID-19) as per the hospital policy. All participants will be followed up for a period of two years for development of symptomatic Influenza or SARS CoV2 infection. A Respiratory viruses Resource Centre will be set up at AIIMS New Delhi to prepae training and advocacy materials for liaising with a diverse set of stakeholders ranging from general population, healthcare professionals to policy makers.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12264", "attributes": { "award_id": "1IK6HX003765-01", "title": "HSR&D Research Career Scientist Award", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 25483, "first_name": "Anashua RANI", "last_name": "Elwy", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1976, "ror": "", "name": "EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "A. Rani Elwy, PhD, is a 20-year VA health services researcher and implementation scientist, based at the Center for Healthcare Organization and Implementation Research, a VA HSR&D Center of Innovation at the VA Bedford Healthcare System. Her work exemplifies HSR&D’s embedded research goals: products and deliverables from her work are now part of VHA national policy and practice. Dr. Elwy has served as Principal Investigator on three HSR&D grants (IAC 07-087, IIR 07-199, and SDR 11-440), and as PI or MPI on four QUERI projects, partnered evaluation initiatives and programs (RRP 13-436; PEC 16-354; QUE 20-017; EBP 22-104). She has also served as PI or subaward PI on an additional 16 grants, and co-investigator on 22 further grants, funded by HSR&D, QUERI, CSR&D, NIH, CDC and PCORI. She has published 106 peer- reviewed articles, and has delivered 69 invited and 54 peer-reviewed international, national and regional presentations. She has received the HSR&D Best Research Paper Award, four Excellence in Teaching Awards, and is a Fellow of the Society of Behavioral Medicine. Dr. Elwy’s work has been cited in national and international media such as CBS News, The Washington Post, U.S. News and World Report, and the UK’s Daily Mail. She serves on COVID-19 workgroups of the World Health Organization and the White House Office of Science and Technology Policy, and attended, by invitation, the White House Summit on the Future of COVID-19 Vaccines. Dr. Elwy is a former fellow of the Implementation Research Institute, and is a Professor of Psychiatry and Human Behavior and Professor of Behavioral and Social Sciences at Brown University. Through HSR&D and QUERI funding, Dr. Elwy has created evidence to answer research questions important to VA leaders, developed deliverables and tested these through implementation projects, and generated sustainment for this evidence-base through changes in national policy and practice within the Veterans Health Administration. This evidence to implementation to sustainment roadmap has been possible through extensive training in implementation science, received through Dr. Elwy’s roles as QUERI implementation research coordinator, NIH-VA implementation science trainee, and VA health services researcher and implementation science principal investigator. Dr. Elwy continuously gives back to the implementation science field, serving as invited faculty on NIH-funded implementation science training courses since 2016, participating in national organizations and committees seeking to use implementation science to improve health and health care, and serving as a committed mentor to 53 graduate students, postdoctoral fellows and early career faculty over the course of her 20-year career. Dr. Elwy’s career goals are to improve Veterans’ health and health care, through building VA implementation science capacity, and training and mentoring the next generation of VA researchers. Her strategies for providing support and caring through mentorship, developed through years of navigating her own health services and implementation science career, are the focus of her “Behind the Scenes CV”, a behind the scenes look at success that is not always understood and recognized by mentees, and what is needed for building and retaining the VA health services research and implementation science workforce. A Research Career Scientist Award will allow Dr. Elwy to devote even more of her time to ensuring that HSR&D does not lose highly regarded, talented, and skilled scientists as a result of misplaced perceptions of what it takes to succeed as a VA health services researcher. Additionally, a Research Career Scientist Award will provide the time needed for Dr. Elwy to develop expertise in policy implementation, a necessary step in her continued goal of building capacity in implementation science throughout VA. Developing policy implementation skills will allow her to focus on increasing further evidence- based policy implementation, building on her newly-funded QUERI Evidence, Policy and Implementation Center (EBP-22-104) and sharing this knowledge and skills to ensure a broad base of experts in this area.", "keywords": [ "Area", "Award", "Back", "Beds", "Behavior", "Behavioral Medicine", "Boston", "COVID-19", "COVID-19 vaccine", "Caring", "Clinical", "Clinical Services", "Coffee", "Collaborations", "Communication", "Country", "Crutches", "Doctor of Philosophy", "Educational process of instructing", "Ensure", "Ethics", "Evaluation", "Faculty", "Failure", "Fellowship", "Fellowship Program", "Foundations", "Funding", "Future", "Goals", "Grant", "Group Interviews", "HIV", "Health", "Health Promotion", "Health Services", "Health Services Research", "Healthcare", "Healthcare Systems", "Hepatitis", "Homogeneously Staining Region", "Hour", "Human", "Integrated Health Care Systems", "International", "Interview", "Knowledge", "Learning", "Leg", "Life", "Light", "Los Angeles", "Love", "Manuscripts", "Mentors", "Mentorship", "Mission", "National Institute of Mental Health", "Occupations", "Operations Research", "Operative Surgical Procedures", "Paper", "Patient-Centered Care", "Peer Review", "Perception", "Policies", "Policy Maker", "Positioning Attribute", "Postdoctoral Fellow", "Principal Investigator", "Productivity", "Psychiatry", "Publishing", "Reporting", "Research", "Research Institute", "Research Personnel", "Research Support", "Rest", "Role", "Rupture", "Schedule", "Science", "Scientist", "Societies", "Son", "Surface", "Talents", "Technology", "Telephone", "Testing", "Time", "Training", "Training Programs", "Travel", "United States National Institutes of Health", "Universities", "Veterans", "Veterans Health Administration", "Visit", "Washington", "Work", "World Health Organization", "Writing", "achilles tendon", "base", "behavioral and social science", "career", "disorder prevention", "early-career faculty", "evidence base", "forgetting", "graduate student", "health care service organization", "implementation research", "implementation science", "improved", "innovation", "multidisciplinary", "news", "next generation", "operation", "patient population", "patient safety", "professor", "programs", "repaired", "skills", "sound", "success", "symposium" ], "approved": true } }, { "type": "Grant", "id": "12265", "attributes": { "award_id": "1IK6RX004809-01", "title": "RR&D Research Career Scientist Award Application", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 28149, "first_name": "Melissa A", "last_name": "Kacena", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1636, "ror": "", "name": "RLR VA MEDICAL CENTER", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "A primary goal of my research program is to identify and test new therapeutic approaches to improve and accelerate fracture healing and overall patient outcomes. This includes improving weightbearing, locomotion, and activity, while decreasing the associated pain and inflammation. In my current VA funded studies, we are seeking to determine how Sirtuin-1 (Sirt1, an NAD+ class III histone deacetylase) activators alter fracture healing outcomes. We began examining Sirt1 as a target as our preliminary data showed that mRNA levels of Sirt1 are robustly elevated during fracture healing. We knew that fracture healing is impaired with age, bone loss, inflammation, and with neurodegeneration, and realized that Sirt1 improves all of these conditions. Our ultimate goal is to improve fracture outcomes for Veterans and civilians. Thus, an important objective of our studies is to translate our findings to the clinic. With this in mind, we have successfully obtained one patent (16/392,246, April 23, 2019) and have applied for a second patent (63/153,297, February 24, 2021). The second patent application includes Drs. Philip Low and Jeffery Nielsen as co-Inventors (also collaborators on our current VA Merit award) who are medicinal chemists. With their assistance, we developed a new fracture targeted SRT1720 drug, which we are investigating in our VA Merit studies. Notably, 15 drugs stemming from Dr. Low’s research have entered human clinical trials. Importantly, we have also developed an important collaboration with VA investigator, Dr. Fletcher White, a neuroscientist with expertise in locomotion, pain, and inflammation analyses. Together, our team will investigate whether pharmacological activation of Sirt1 by fracture targeting SRT1720 allows for improved fracture healing, while reducing pain behaviors. Additional studies funded by 3 PI/mPI NIH R01s and internal, foundation and training awards focus on the bone marrow microenvironment and its regulation of fracture healing, bone mass, and hematopoiesis. The goal of NIH R01 AG060621 is to understand the mechanisms by which angiogeneic therapies can improve aged fracture healing. The goal of NIH R01 DK118782 is to understand the mechanisms by which osteomacs and megakaryocytes regulate hematopoiesis. The goal of NIH R01 DK108342 is to examine how CD166 regulates hematopoietic stem cell function and the hematopoietic niche. Pilot funds and an NIH F31 AG077931 PhD fellowship fund investigations on the bone loss following infection with SARS-CoV-2. These studies have significant implications to aiding in rehabilitation of Veterans and improving their quality of life. My lab has been very productive with 52 data driven manuscripts and 17 review articles/chapters published since 2018. During this time, I have given 21 lectures at national/international venues, including an invitation as an Esteemed Speaker for the Australian and New Zealand Bone and Mineral Society meeting in 2019. Continuous extramural funding for the past 15 years has enabled us to achieve our research goals. I have also been extensively involved with mentoring junior faculty, post-doctoral fellows, clinical residents, graduate students, medical students, undergraduate students, and high school students for more than 20 years (>100 mentees). I have served on numerous grant review committees at national and international levels including as a permanent member of the NIH, Skeletal Biology Development and Disease (SBDD) Study Section and will begin reviewing VA Merit Awards in 2023. I have served/am serving on the Editorial Review Board for the Journal of Orthopaedic Research and JBMR Plus; as a Guest Editor for Frontiers in Endocrinology; section editor for Current Osteoporosis Reports; and am Editor-in-Chief for Current Osteoporosis Reports. I have also been nominated and elected into leadership roles within several institutions/societies. Currently, I am the Vice Chair for Research for the Department of Orthopaedic Surgery at IUSM and am an elected member of the Council for the American Society for Bone and Mineral Research. These research, mentoring, leadership, and service activities highlight the significance and recognition of my research activities to the musculoskeletal field.", "keywords": [ "2019-nCoV", "ALCAM gene", "Acceleration", "Accidents", "Accounting", "Age", "Aging", "American", "American Society of Hematology", "Amputation", "Analgesics", "Animal Model", "Applications Grants", "Award", "Biography", "Biology", "Blood", "Bone Marrow", "Bone Regeneration", "Book Chapters", "Caring", "Cells", "Clinic", "Clinical", "Clinical Trials", "Collaborations", "Data", "Defect", "Department of Defense", "Development", "Devices", "Diabetes Mellitus", "Disease", "Doctor of Philosophy", "Drug Targeting", "Endocrinology", "Equipment", "Extramural Activities", "Faculty", "Family suidae", "Fellowship", "Foundations", "Fracture", "Funding", "Future", "Goals", "Grant", "Grant Review", "Growth Factor", "Health", "Healthcare", "Hematopoiesis", "Hematopoietic", "Hematopoietic stem cells", "High Fat Diet", "High School Student", "Histone Deacetylase", "Human", "Impairment", "Indiana", "Infection", "Inflammation", "Injury", "Institution", "Intellectual Property", "International", "Investigation", "Journals", "Leadership", "Legal patent", "Limb structure", "Locomotion", "Manuscripts", "Medical", "Medical Students", "Medicine", "Megakaryocytes", "Mentors", "Messenger RNA", "Military Personnel", "Minerals", "Modeling", "Modernization", "Mus", "Musculoskeletal", "Natural regeneration", "Nerve Degeneration", "New Zealand", "Non-Insulin-Dependent Diabetes Mellitus", "Obesity", "Occupational Therapy", "Open Fractures", "Operative Surgical Procedures", "Opioid", "Orthopedic Surgery", "Orthopedics", "Osteoporosis", "Outcome", "Overdose", "Overweight", "Pain", "Pain management", "Patient-Focused Outcomes", "Peer Review", "Pharmaceutical Preparations", "Population Projection", "Postdoctoral Fellow", "Productivity", "Prosthesis", "Publications", "Publishing", "Quality of life", "Recovery", "Regimen", "Regulation", "Rehabilitation therapy", "Reporting", "Research", "Research Activity", "Research Personnel", "Review Committee", "Risk", "Roentgen Rays", "Role", "SIRT1 gene", "Scientist", "Seminal", "Services", "Sheep", "Side", "Site", "Societies", "Soldier", "Space Flight", "Study Section", "Surgeon", "System", "Testing", "Therapeutic Agents", "Thrombopoietin", "Time", "Tissues", "Training", "Translating", "Trauma", "United States National Institutes of Health", "Universities", "Veterans", "War", "Weight-Bearing state", "Wheelchairs", "Work", "active duty", "aged", "angiogenesis", "animal efficacy", "bone", "bone fracture repair", "bone healing", "bone" ], "approved": true } }, { "type": "Grant", "id": "12266", "attributes": { "award_id": "1IK6HX003768-01", "title": "HSR&D Research Career Scientist Award", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 23769, "first_name": "Marianne", "last_name": "Matthias", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1636, "ror": "", "name": "RLR VA MEDICAL CENTER", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1636, "ror": "", "name": "RLR VA MEDICAL CENTER", "address": "", "city": "", "state": "IN", "zip": "", "country": "United States", "approved": true }, "abstract": "My research focuses on understanding and improving chronic pain management for Veterans by leveraging my expertise in health communication, patient engagement, and relationship-centered care. Over the past 14 years, my work has developed from observational to interventional, steadily increasing the impact of my scholarship on Veterans’ care. My research has helped to advance our understanding of how communication shapes healthcare experiences and Veterans’ pain management. Early observational work led to insights into the role of the patient-provider relationship and social support in pain self-management, treatment decision- making, and opioid management, including opioid tapering. I have successfully built upon these findings with each new project, which has led to the design and testing of interventions to improve pain management for Veterans. These interventions have included developing and testing a peer-supported pain self-management program, a coaching program designed to increase patient activation for Black Veterans with chronic pain to help address racialized disparities in pain management, and a shared decision-making intervention to overcome patient-level barriers to use of and adherence to evidence-based nonpharmacologic pain treatments. Beyond developing and testing interventions, I am also moving toward implementation in an effort to broaden my impact and improve care for Veterans. My health equity study, COOPERATE, significantly increased patient activation and communication self-efficacy, while producing other positive outcomes for Black Veterans. In light of these positive results I will be exploring avenues for implementation through our operational partners as well as likely submitting a proposal for a Hybrid Type 2 multi-site effectiveness/implementation study, to further test COOPERATE and prepare for system-wide implementation. COOPERATE represents an important path to achieving health equity for Black Veterans with chronic pain and as such, also represents the increasing impact of my research. My newly-funded study, OPTIONS, also has direct relevance for Veteran care and impact. OPTIONS reflects VA’s priorities of reducing reliance on opioids and increasing use of multimodal care, including evidence-based complementary and integrative therapies and other nonpharmacologic approaches to chronic pain. As such, I have partnered with the VA National Pain Management, Opioid Safety, and Prescription Drug Monitoring Program Office and the Office of Patient- Centered Care and Cultural Transformation, and, assuming positive results, these partnerships will help increase the project’s impact by facilitating VA-wide dissemination and, ultimately, implementation. These examples reflect the evolution of my work from early observational studies to intervention studies, which will ultimately lead to system-wide implementation and greater impact on Veterans’ pain care. The other study I am currently leading as co-PI, CIPHER, is focused on understanding effects of COVID-19-related disruptions in pain care on Veterans with chronic low-back pain, with particular emphasis on disruptions to nonpharmacologic care, which can be more difficult to deliver via telehealth. Using a mixed-methods design with VA administrative data and qualitative interviews with clinicians and Veterans purposefully sampled from the administrative data, we are partnering with the VA National Pain Management Office to understand changes in care and, ultimately, apply these lessons to improving pain care for Veterans.", "keywords": [ "Academy", "Address", "Adherence", "Affect", "American", "Anxiety", "Area", "Award", "Black race", "COVID-19 impact", "Caring", "Categories", "Chronic low back pain", "Clinic Visits", "Clinical", "Clinical Sciences", "Clinical Trials", "Communication", "Compassion", "Complementary therapies", "Conceptions", "Conflict (Psychology)", "Counseling", "Data", "Decision Making", "European", "Evolution", "Follow-Up Studies", "Fostering", "Funding", "Goals", "Health", "Health Services", "Healthcare", "Homogeneously Staining Region", "Hybrids", "Integrative Therapy", "Internal Medicine", "International", "Intervention", "Intervention Studies", "Interview", "Journals", "K-Series Research Career Programs", "Learning", "Light", "Medicine", "Mental Depression", "Methods", "New South Wales", "New Zealand", "Observational Study", "Office Management", "Opioid", "Outcome", "Pain", "Pain management", "Participant", "Patient Education", "Patient-Centered Care", "Patients", "Peer Review", "Personal Satisfaction", "Physicians", "Play", "Policies", "Positioning Attribute", "Postdoctoral Fellow", "Provider", "Public Health", "Publications", "Publishing", "Quality of life", "Recommendation", "Research", "Research Personnel", "Role", "Safety", "Sampling", "Scholarship", "Scientist", "Self Efficacy", "Self Management", "Services", "Shapes", "Site", "Social support", "Societies", "System", "Testing", "Time", "Trust", "Uncertainty", "United States National Institutes of Health", "Veterans", "Work", "career", "chronic pain", "chronic pain management", "college", "coping", "design", "effective intervention", "effectiveness/implementation study", "evidence base", "experience", "health care disparity", "health communication", "health equity", "improved", "indexing", "insight", "multi-site trial", "multimodality", "novel", "novel strategies", "opioid tapering", "pain self-management", "patient engagement", "patient-clinician communication", "patient-level barriers", "peer support", "prescription monitoring program", "programs", "racial disparity", "randomized trial", "self-management program", "shared decision making", "telehealth", "therapy design", "tool" ], "approved": true } }, { "type": "Grant", "id": "15485", "attributes": { "award_id": "1I01BX006456-01A1", "title": "Nanoformulations for Respiratory Infections", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2024-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 24037, "first_name": "SUBHRA", "last_name": "MOHAPATRA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1638, "ror": "", "name": "JAMES A. HALEY VA MEDICAL CENTER", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 23775, "first_name": "Shyam S", "last_name": "Mohapatra", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1638, "ror": "", "name": "JAMES A. HALEY VA MEDICAL CENTER", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 1638, "ror": "", "name": "JAMES A. HALEY VA MEDICAL CENTER", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The members of the Coronavirus family including severe acute respiratory syndrome (SARS) coronavirus 1 (SARS-CoV1), MERS-CoV and SARS-CoV-2 (synonym: CoV2), have caused pandemics respectively in 2003, 2012 and 2019 suggesting the possibility of a future pandemic by this virus family. Also, following the COVID-19 pandemic, there was an increase in other seasonal respiratory infections such as influenza and respiratory syncytial virus (RSV). Severe respiratory viral infections can cause robust viral replication and a strong ‘cytokine storm’ leading to acute respiratory distress syndrome and pneumonia often leading to death in the case of elderly (>65 years of age). Currently, a limited number of moderately effective therapies are available, hence there is a dire need to develop additional novel therapeutics against respiratory infections. The main premise of this proposal is to develop a broad-spectrum antiviral intranasal nanoformulation using CoV2 and RSV as models. To this end, a liposomal nanosystem comprising alpha linolenic-acid (ALA) and acetate (acronym: LAN) has been established, wherein liposomes composed of ALA incorporate acetate in the lipid bilayer that can activate type-I IFN pathway and inhibit viral replication. Also, ALA binding to viral fusion proteins disrupts LANs releasing acetate. Based on this progress, herein it is proposed to incorporate in the core a slow-sustained release nanochitosan particle complexed with pDNA(s) encoding short-hairpin RNAs (pshRNA) for CoV2/RSV. Thus, a novel set of candidate shRNAs has been identified, which synergistically decreases CoV2 replication and overall infection. All data at hand taken together have led to the central hypothesis that the development of a LAN with virus-specific regimens such pshRNA(s) can act in an additive or synergistic manner to produce the most robust therapy against severe respiratory infections. This hypothesis will be tested in the following two aims. Aim #1 will test the hypothesis that incorporating pshRNA to the LAN core (pshLAN) can make a more potent antiviral, and to this end, it is proposed to synthesize and characterize pshLAN, test for synergy in vitro in lung epithelial cell and air-liquid organoid cultures, and test biodistribution and toxicity of LAN/pshLAN in vivo. In Aim #2, to test whether LANs with pshRNAs endow synergistic therapeutic efficacy in vivo, it is planned to compare the efficacy of pshLAN vs LAN using aged mouse models of viral infections by CoV2-MA10 or clinical RSV isolates and examine the mechanism of efficacy and synergy in vivo. All required resources and facilities including access to Nanomedicine Core and the BSL3/ABSL3 facilities for CoV2 research are in place. The investigative team is uniquely poised to test whether the proposed core-shell LAN-based nanomedicine can effectively treat CoV2 and/or RSV infections, which can be extended to other infections in the future.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "15486", "attributes": { "award_id": "1I01BX006421-01A1", "title": "Markers and Mechanisms of PASC", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2024-10-01", "end_date": "2028-09-30", "award_amount": null, "principal_investigator": { "id": 23928, "first_name": "JONATHAN P", "last_name": "MOORMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1662, "ror": "", "name": "JAMES H QUILLEN VA MEDICAL CENTER", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1662, "ror": "", "name": "JAMES H QUILLEN VA MEDICAL CENTER", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "Inflammatory responses to SARS-CoV-2 infection play a major role in COVID-19 pathogenesis, as the expression of various inflammatory mediators/regulators correlates with the disease severity and mortality rates. While the majority of COVID-19 patients fully recover from the infection and become asymptomatic, approximately one-third of COVID-19 survivors experience a wide spectrum of symptoms and/or complications beyond 4 weeks from the onset of the disease, now designated as “post-acute sequelae of COVID-19 (PASC)”; and this syndrome has become increasingly recognized and concerning. While the molecular basis of PASC is unknown, its clinical healthcare impacts are enormous, raising an urgent need to study long-term outcomes in our Veteran COVID-19 survivors. The objectives of this proposal are to identify and characterize biomarker(s) and molecular/cellular mechanisms for the PASC in COVID-19 survivors to better understand and manage this post-infection syndrome. Our recent investigations into the biochemical and cellular responses to SARS-CoV-2 infection revealed sustained inflammation and immunosuppression in COVID-19 survivors with PASC - also called COVID-19 long haulers (COV-LH). Specifically, we discovered significant changes in the expression of multiple inflammatory proteins in COVID-19 survivors, especially in COV-LH, suggesting persistent inflammation in these subjects. We also found significant increases in myeloid-derived suppressor cells (MDSCs), along with decreases in the numbers and functions of natural killer (NK) cells in these subjects. Importantly, the increase in MDSCs was associated with a decrease in NK cells in COV-LH compared with COVID-19 asymptomatic survivors (COV-AS), indicating sustained immunosuppression in these subjects. Based on our findings, we designed a research plan to address three critical questions: 1) Can unique signature molecules be identified as biomarkers for COV-LH? 2) Do these regulatory molecules promote MDSC expansion and suppressive functions in COV-LH? 3) Are these regulatory molecules and/or is MDSC-mediated immunosuppression responsible for the development of PASC in COV-LH? Based on our preliminary studies, we hypothesize that SARS-CoV-2 infection induces systemic inflammation and epigenetic and metabolic changes, leading to persistent inflammation and immunosuppression and the development of PASC in COVID-19 survivors. We propose three specific aims to test our hypothesis: Aim 1 will identify potential biomarkers and investigate their transcriptional dysregulations in COVID-19 survivors. Aim 2 will determine the molecular mechanisms that promote MDSC expansion and suppressive functions in COVID-19 survivors. Aim 3 will determine the role of regulatory molecules and MDSC-induced immunosuppression in the development of PASC in COVID-19 survivors. Because there are no known molecular or cellular biomarkers for the diagnosis and treatment of PASC, information gained from this research will not only fill major knowledge gaps in understanding this post-COVID- 19 syndrome, but will also facilitate identifying and managing PASC symptoms in our Veteran COVID-19 survivors.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1424, "count": 14236 } } }