Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1442&sort=approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=approved" }, "data": [ { "type": "Grant", "id": "12075", "attributes": { "award_id": "1K08CA277011-01A1", "title": "Differential Wnt Dependencies in Colon Epithelium.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 27928, "first_name": "Susan E", "last_name": "Lim", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-08-31", "award_amount": 196204, "principal_investigator": { "id": 27929, "first_name": "GEORGE", "last_name": "ENG", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "This proposal details a five-year training plan for the development of a research program focused on elucidating the therapeutic potential of superimposed additional Wnt signaling on colonic neoplasia. The molecular driver shared across the vast majority of colonic neoplasms is constitutive Wnt signaling, most commonly caused by loss of function mutations in the APC gene. The loss of function of APC permits beta catenin to constitutively translocate to the nucleus and induce the formation of colonic adenomas which can further mutate into colon cancer. To date, strategies to inhibit Wnt signaling for therapeutic purposes have failed. However, other elements of the beta catenin destruction complex that work with APC, such as GSK3 alpha and beta can be pharmacologically inhibited. Therefore, instead of inhibiting Wnt signaling, and informed by the concept that a “just right” amount of Wnt signaling may be selected for in tumor cells, we hypothesized additional Wnt signaling would be deleterious to tumor cells but would simultaneously enhance the function of normal cells. This project will elucidate fundamental dependencies of Wnt signaling in normal tissues as well as tumors. Ultimately, I believe this will engender a specific therapy for adenomas, to which there is no existing medical therapy other than polypectomy, and additionally provide a broadly applicable and potentially safe approach to treat colorectal cancer. I am clinically trained pathologist and physician scientist seeking K08 support for mentored research. This work will be mentored by Prof. Omer Yilmaz and Prof. Robert Langer. Prof. Yilmaz is a pathologist and physician-scientist, and studies the effects of diet on intestinal stem cells and state- of-the-art intestinal organoid models. Prof. Langer has fundamentally transformed and defined biomedical engineering, is the most cited engineer in history, and most recently his expertise in nanoparticle delivery provided the foundation for the Moderna COVID-19 vaccine. The work will be conducted at the Massachusetts Institute of Technology and Massachusetts General Hospital, both world class institutions of the highest caliber. I have assembled a scientific advisory committee consisting of world class cancer biologists to help guide my scientific progress, consisting of Prof. Tyler Jacks, Prof. Michael Yaffe, and Prof. William Kaelin. This K08 mentored research award will ensure I have the time and resources to develop expertise in cancer biology and explore this promising therapeutic and biologically intriguing concept of increased Wnt signaling to specifically treat colonic neoplasia. This topic will provide ample substrate for me to grow as an independent physician scientist.", "keywords": [ "APC gene", "APC mutation", "Adenocarcinoma", "Advisory Committees", "Affect", "Agonist", "Award", "Biological Assay", "Biomedical Engineering", "CRISPR interference", "Caliber", "Cancer Biology", "Cancer Model", "Carcinoma", "Cell Nucleus", "Cell Proliferation", "Cell physiology", "Cells", "Clinical", "Colon", "Colon Adenocarcinoma", "Colon Carcinoma", "Colonic Adenoma", "Colonic Neoplasms", "Colorectal Cancer", "Complex", "Data", "Dependence", "Development Plans", "Diet", "Dose", "Elements", "Engineering", "Ensure", "Epithelium", "Essential Genes", "Exhibits", "Foundations", "Frequencies", "General Hospitals", "Genes", "Genetic", "Glycogen Synthase Kinase 3", "Growth", "Human", "Institution", "Intestines", "KRAS2 gene", "Knock-out", "Lesion", "Location", "Loss of Heterozygosity", "Maintenance", "Malignant Neoplasms", "Massachusetts", "Medical", "Mentors", "Modeling", "Moderna COVID-19 vaccine", "Molecular", "Mus", "Mutate", "Mutation", "Normal Cell", "Normal tissue morphology", "Oncogenic", "Organoids", "Pathologist", "Pathway interactions", "Patients", "Physicians", "Polypectomy", "Pre-Clinical Model", "Protein Kinase", "Proteins", "Recording of previous events", "Research", "Resources", "Rho-associated kinase", "Scientist", "Signal Transduction", "Specimen", "Stereotyping", "TP53 gene", "Technology", "Therapeutic", "Time", "Toxic effect", "Training", "WNT Signaling Pathway", "Wnt proteins", "Work", "adenoma", "beta catenin", "clinical care", "colon cancer treatment", "human model", "improved", "in vivo", "inhibitor", "knock-down", "loss of function", "loss of function mutation", "mouse model", "mutant", "nanoparticle", "nanoparticle delivery", "neoplastic cell", "novel", "pharmacologic", "progenitor", "programs", "small molecule inhibitor", "stem cells", "success", "targeted treatment", "transcriptome sequencing", "transcriptomics", "tumor", "tumor growth" ], "approved": true } }, { "type": "Grant", "id": "12076", "attributes": { "award_id": "1R01NS133905-01", "title": "Mechanisms of cognitive control impairment in ME/CFS and PASC-ME/CFS", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Neurological Disorders and Stroke (NINDS)" ], "program_reference_codes": [], "program_officials": [ { "id": 10999, "first_name": "Vicky R", "last_name": "Whittemore", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-07-31", "award_amount": 490883, "principal_investigator": { "id": 27930, "first_name": "H Hamdi", "last_name": "Eryilmaz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27931, "first_name": "Michael B", "last_name": "VanElzakker", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 736, "ror": "https://ror.org/002pd6e78", "name": "Massachusetts General Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a symptom-based diagnosis characterized by severe debilitating fatigue, cognitive dysfunction, and widespread pain. Most cases of ME/CFS begin with a viral infection or involve multiple exposures to pathogens over time. Soon after the onset of the COVID-19 pandemic, a significant portion of patients infected with SARS-CoV-2 developed chronic symptoms that overlap greatly with those of ME/CFS. Among the post-acute sequelae of COVID-19 (PASC), “brain fog” symptoms have been widely reported including in patients with mild initiating infection. Many PASC patients meet the diagnostic criteria for ME/CFS after 6 months of ongoing symptoms (referred to herein as PASC- ME/CFS). Given the growing number of SARS-CoV-2 infections, the disease burden on individuals with ME/CFS and PASC-ME/CFS, and the challenges associated with these conditions such as rehabilitation and workforce disruptions, elucidating the mechanisms of cognitive deficits in ME/CFS and PASC-ME/CFS is of clear", "keywords": [ "Acceleration", "American", "Anterior", "Attention", "Autonomic Dysfunction", "Brain", "Brain imaging", "COVID-19 pandemic", "COVID-19 patient", "Chronic Fatigue Syndrome", "Clinical Trials", "Cognition", "Cognitive deficits", "Complement", "Conflict (Psychology)", "Data", "Diagnosis", "Dorsal", "Electroencephalography", "Electrophysiology (science)", "Exertion", "Exhibits", "Exposure to", "Fatigue", "Functional Magnetic Resonance Imaging", "Functional disorder", "Future", "Goals", "Immunologics", "Impaired cognition", "Impairment", "Individual", "Infection", "Inflammation", "Long COVID", "Malaise", "Measures", "Memory", "Methods", "Neurobehavioral Manifestations", "Neurocognitive Deficit", "Pain", "Patients", "Pattern", "Performance", "Peripheral", "Pilot Projects", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Psychoses", "Qualifying", "Reaction Time", "Rehabilitation therapy", "Reporting", "Research", "SARS-CoV-2 infection", "Short-Term Memory", "Source", "Symptoms", "Time", "Virus Diseases", "Work", "biomarker identification", "brain fog", "burden of illness", "cingulate cortex", "cognitive control", "comparison control", "coronavirus disease", "cost", "cytokine", "diagnostic criteria", "effective intervention", "experience", "improved", "inflammatory marker", "multimodality", "neuroimaging", "neuromechanism", "neurophysiology", "neuropsychiatry", "novel", "pathogen", "persistent symptom", "predictive modeling", "targeted biomarker", "targeted treatment", "temporal measurement", "therapy development", "tool" ], "approved": true } }, { "type": "Grant", "id": "12077", "attributes": { "award_id": "1R01HD108160-01A1", "title": "Strengthening Parenting, Young Children's Social-Behavioral Competence, and Kindergarten Readiness in Schools Serving Low-Income Communities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8605, "first_name": "JAMES", "last_name": "GRIFFIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-06-30", "award_amount": 718648, "principal_investigator": { "id": 27932, "first_name": "Amie F", "last_name": "Bettencourt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27933, "first_name": "Deborah A.", "last_name": "Gross", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Social, emotional, and behavioral (SEB) problems are among the most common chronic disabilities affecting children growing up in urban and rural poverty. They also have implications for children’s school success as they affect essential social-emotional learning skills such as the ability to comply with rules, follow instructions, regulate emotions, and get along with others. These essential skills are first learned before kindergarten (K) entry, in the context of a supportive, responsive, and consistent parenting relationship. To date, universal school-based interventions to improve young children’s social-emotional learning have primarily targeted students and teachers. Yet, parents are the central figures in young children’s lives and they need to be equal partners with schools in promoting SEB skills. This study seeks to improve children’s SEB competence and K readiness by strengthening parent engagement and parenting skills in early childhood education during prekindergarten (PreK). This hybrid Type 2 effectiveness-implementation trial will rigorously evaluate the effects of an evidence-based parenting program, called the Chicago Parent Program (CPP), implemented in PreK on K outcomes in urban and rural Title 1 schools in Maryland. Effectiveness Aims: Using a cluster randomized design (N=30 schools, 840 families; >90% low-income), we will examine the effects of CPP offered universally to Title 1 PreK parents on a) children’s SEB competence, parent engagement, and parenting skills; and b) K readiness, chronic absence, and grade retention in K. We will also examine the mechanisms underlying those effects. Schools will be stratified by rural vs urban district then randomized to experimental (CPP) or control (usual practice) conditions. Data will be collected from multiple informants (parents, teachers, CPP group leaders, school personnel, district administrative data). Implementation Aim: Using the RE-AIM framework and a mixed methods approach, we will assess CPP reach, effectiveness, acceptability, adoption, implementation, cost-effectiveness, and sustainability when offered in different formats (virtual CPP groups vs in-person CPP groups) and contexts (urban vs rural schools). Schools will participate for 2 years with experimental schools offering CPP twice, once in a virtual group format and once in an in- person group format (format counterbalanced), giving us the ability to compare a range of outcomes associated with uptake, acceptability, cost, and sustainability by CPP format in low-resource rural and urban contexts. This study addresses the NICHD priority to test developmentally informed interventions designed to ameliorate early adverse environmental effects on children and optimize their growth, development, and SEB wellbeing. Children’s SEB health and school success are inextricably linked and both are adversely affected by racial and economic inequities that have been exacerbated by the COVID-19 pandemic, heightening the urgency of this research for supporting children, families, and schools.", "keywords": [ "Address", "Adoption", "Affect", "Baltimore", "Behavioral", "COVID-19", "COVID-19 pandemic", "Chicago", "Child", "Child Rearing", "Child Support", "Child Welfare", "Chronic", "Cities", "Communities", "Competence", "Data", "Development", "Economics", "Education", "Effectiveness", "Emotional", "Emotions", "Exhibits", "Family", "Foundations", "Growth", "Growth and Development function", "Human Resources", "Hybrids", "Inequity", "Instruction", "Intervention", "Learning", "Learning Skill", "Link", "Low income", "Maryland", "Mediating", "Mental Health", "Methods", "National Institute of Child Health and Human Development", "Nursery Schools", "Outcome", "Parents", "Personal Satisfaction", "Persons", "Problem Solving", "Problem behavior", "Program Effectiveness", "Quality of life", "Race", "Randomized", "Reach Effectiveness Adoption Implementation and Maintenance", "Readiness", "Research Support", "Resources", "Role", "Rural", "Schools", "Students", "Testing", "behavioral health", "cluster randomized design", "cost", "cost effectiveness", "design", "disability", "early childhood", "effectiveness/implementation trial", "evidence base", "experience", "externalizing behavior", "improved", "informant", "kindergarten", "pandemic disease", "physical conditioning", "post intervention", "programs", "rural poverty", "school district", "skills", "social", "social emotional learning", "social interventions", "success", "teacher", "therapy design", "uptake", "urban poverty", "virtual", "virtual group" ], "approved": true } }, { "type": "Grant", "id": "12078", "attributes": { "award_id": "1R25GM150141-01", "title": "Convoy: A Cultural approach of Navajo Youth to Biomedical Sciences", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 9054, "first_name": "LAWRENCE A.", "last_name": "BECK", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-07-31", "award_amount": 269394, "principal_investigator": { "id": 27934, "first_name": "Shazia Tabassum", "last_name": "Hakim", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 969, "ror": "", "name": "DINE' COLLEGE", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "Summary: Project Title: CONVOY: A Cultural approach of Navajo Youth to Bio- medical Sciences. Need Assessment: STEM Learning Ecosystems are localized multi-stakeholder collaborative networks (MSCNs) that are “dynamic collaborations among schools, out-of-school time programs, STEM expert institutions (eg., museums, science centers, and institutions of higher education), the private sector, community-based organizations, youth and families”, and has been identified as one of the key sources to harvest human capital and contribute to novel interventions through the development of advanced knowledge. We will create a bridge between traditional indigenous knowledge and modern biomedical science via “CONVOY”. Peer Groups: Numerous peer groups focus on the development of K-12 and undergraduate research and education programs for underserved minority communities, but there are very few who are focusing on healthcare and biomedical sciences. This proposed activity will provide the students with health disparity-related research experiences, hands-on laboratory training, and other educational and communication opportunities via Science Café and Health Fairs to prepare them for future leadership and careers in healthcare, biopharma, and other associated professions. Proposal: “CONVOY” project will bring together students from Junior high schools, high schools (mentees) and Diné College (mentor avatars) in order to spawn their enduring curiosity in biomedical and health sciences — especially among Navajo (Diné) youth and students from other underserved communities— while adapting the concept of “near-peer” network to bring forward the local health issues to the open forums. Specific Aims: CONVOY, identifies causal links between Indigenous traditional knowledge and modern science to achieve four specific aims i.e., 1) Motivate Navajo high school and junior high school students to study and pursue careers in Biomedical Sciences and related fields; 2) Nurture holistic practices that bridge the gap between Navajo traditional practices and western medicine to develop a marketable land based solution, while focusing on problems faced by local communities; 3) Prepare students to enroll in institutions of higher learning and provide opportunities to earn college credit in high school through Dine College’s Dual Enrollment Program for biomedical sciences, and 4) Develop curriculum for a 10-week summer program to support activities by “CONVOY”. Expected Outcome: the benefits of the “Convoy” will include but are not limited to: i) Development of a need appropriate support system (near-peer-mentorship) that will serve as a main technical support for training and innovative research to help provide better healthcare services, ii) Greater understanding of the local epidemiology of infections, diseases and health disparities, iii) Increase local workforce development in several critical areas that have implications broader than current COVID-19 pandemic or other infections and diseases.", "keywords": [ "Advanced Development", "Ally", "Area", "COVID-19 pandemic", "Collaborations", "Communication", "Communities", "Critical Thinking", "Curiosities", "Development", "Diné Nation", "Disease", "Dual Enrollment", "Ecosystem", "Education", "Educational Curriculum", "Enrollment", "Epidemiology", "Epistemology", "Family", "Focus Groups", "Fostering", "Future", "Harvest", "Health", "Health Disparities Research", "Health Fairs", "Health Professional", "Health Sciences", "Healthcare", "Indigenous", "Infection", "Institution", "Intervention", "K-12 student", "Knowledge", "Leadership", "Learning", "Link", "Medicine", "Mentors", "Mentorship", "Middle School Student", "Modeling", "Modernization", "Museums", "Navajo", "Needs Assessment", "Nursery Schools", "Outcome", "Pathway interactions", "Peer Group", "Private Sector", "Public Health", "Research", "Resources", "STEM career", "STEM program", "Schools", "Science", "Source", "Students", "Support System", "Testing", "Time", "Training Support", "Workforce Development", "Youth", "career", "college", "community organizations", "disease disparity", "experience", "health care service", "health disparity", "high school", "higher education", "human capital", "innovation", "laboratory experience", "minority communities", "novel", "peer", "peer networks", "programs", "summer program", "undergraduate education", "undergraduate research", "underserved community", "underserved minority", "university student" ], "approved": true } }, { "type": "Grant", "id": "12079", "attributes": { "award_id": "1R01HL166269-01A1", "title": "Identifying patient subgroups and processes of care that cause outcome differences following ICU vs. ward triage among patients with acute respiratory failure and sepsis", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 23263, "first_name": "JANE", "last_name": "YE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2027-06-30", "award_amount": 751831, "principal_investigator": { "id": 27935, "first_name": "Scott D", "last_name": "Halpern", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 23007, "first_name": "Vincent", "last_name": "Liu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 769, "ror": "", "name": "KAISER FOUNDATION RESEARCH INSTITUTE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Decisions to admit patients with acute respiratory failure (ARF) and sepsis (the most common and lethal cause of the acute respiratory distress syndrome) to intensive care units (ICUs) are highly variable across the US. And, yet, these triage decisions have a substantial impact on patient outcomes. In our prior work, we used detailed electronic health record (EHR) data from 9.2 million hospitalizations and found that decisions to admit ARF patients to wards were associated with a 3.8% absolute increase in mortality. In contrast, choices to admit sepsis patients to ICUs resulted in considerably longer length of stay and a 5.1% absolute increase in death. The nationwide impact of such discretionary triage would be exponentially greater. Our findings highlight tremendous opportunities to improve ARF and sepsis outcomes by identifying the patient subgroups and processes of care that most strongly contribute to the benefits and harms of ICU- versus ward-based care. This application proposes to update our ARF and sepsis cohort such that it includes all admissions from 2013 through 2022 across 29 hospitals in the Kaiser Permanente Northern California and University of Pennsylvania health systems, and incorporate more than 100 more data fields per patient. This curation of highly granular EHR data will enable us to identify the: (1) distinct patient subgroups and phenotypes among those meeting the syndromic criteria of `ARF' and `sepsis;' and the (2) processes of care and (3) inpatient complications that causally explain the observed associations of ICU vs. ward triage with patient outcomes. Our multidisciplinary team will apply diverse expertise in instrumental variable regression, mediation analyses, machine learning, complex EHR data, and probabilistic phenotyping to complete three aims that promote our long-term goal of improving care, and hence outcomes, for patients with ARF and sepsis regardless of where they are treated. Several methodological innovations will enable us to achieve these goals, and, in turn, to not only surmount key limitations of prior studies that sought to determine which acutely ill patients benefit from ICU admission, but identify the mechanisms underlying such triage effects. These data will also allow us to quantify the impact of COVID-19 on ICU and ward triage patterns, care processes, and outcomes among ARF and sepsis patients, thereby modernizing our results and enabling their applicability to pandemic eras. Completing the aims of this study will improve public health by identifying ways in which emergency departments, ICUs, and wards can improve outcomes for the more than 4 million Americans hospitalized each year with ARF and/or sepsis. Such results will enable development and testing of personalized triage algorithms, and guide optimal care for patients without always requiring ICU admission, thereby improving patient outcomes, reducing health care costs, and preserving ICU capacity for patients who truly need it.", "keywords": [ "Accident and Emergency department", "Accounting", "Acute", "Acute Renal Failure with Renal Papillary Necrosis", "Acute Respiratory Distress Syndrome", "Acute respiratory failure", "Admission activity", "Affect", "Algorithms", "American", "Antibiotics", "COVID-19", "COVID-19 impact", "California", "Caring", "Cessation of life", "Chronic Obstructive Pulmonary Disease", "Classification", "Clinical", "Collaborations", "Complex", "Complication", "Consultations", "Data", "Data Set", "Delirium", "Development", "Diagnostic", "Electronic Health Record", "Elements", "Goals", "Guidelines", "Health Care Costs", "Health system", "Heart failure", "Heterogeneity", "Hospitalization", "Hospitals", "Hour", "Iatrogenesis", "Infection", "Inpatients", "Intensive Care Units", "Knowledge", "Length of Stay", "Life", "Liquid substance", "Location", "Machine Learning", "Measures", "Mediation", "Mediator", "Methodology", "Methods", "Modeling", "Outcome", "Palliative Care", "Patient Admission", "Patient Care", "Patient-Focused Outcomes", "Patients", "Pattern", "Pennsylvania", "Phenotype", "Population Heterogeneity", "Probability", "Process", "Public Health", "Recommendation", "Resistance", "Sepsis", "Steroids", "Subgroup", "Syndrome", "Testing", "Triage", "Universities", "Update", "Urinary tract infection", "Work", "acute care", "cohort", "coronavirus disease", "current pandemic", "end of life care", "experience", "future pandemic", "high risk", "improved", "improved outcome", "indexing", "innovation", "insight", "meetings", "mortality", "mortality risk", "multidisciplinary", "novel", "pandemic disease", "patient subsets", "preservation", "septic patients", "treatment pattern", "unsupervised learning", "ward" ], "approved": true } }, { "type": "Grant", "id": "12080", "attributes": { "award_id": "1UG3OD035517-01", "title": "ECHO Renewal for the CANOE Study Cohort", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 21591, "first_name": "Sonia S", "last_name": "Arteaga", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2025-05-31", "award_amount": 1320521, "principal_investigator": { "id": 27936, "first_name": "Tina V", "last_name": "Hartert", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27937, "first_name": "Sarah Scheiderich", "last_name": "Osmundson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "The overarching goals of this application are to: 1) maintain retention of children in the Vanderbilt CANOE birth cohort with emphasis on diversity and implementation of the ECHO Cohort Protocol with high fidelity and conduct new enrollment, and 2) address key questions in the field about one of the most common and modifiable early life environmental exposures consistently associated with significantly increased asthma risk, respiratory syncytial virus (RSV) infection, delineating the severity-dependent and age-dependent effects of RSV infection on asthma risk. This innovative project has significant public health impact, as establishing the age- and severity-dependent relationship between RSV and asthma is the first and most important step in disease primary prevention. We propose to address key unanswered questions in the field: the severity- and age-dependent association of RSV and asthma, and the impact of infection on lung function. In addition, we will explore the broad impact of the SARS-CoV-2 pandemic on asthma incidence and control in an exploratory aim, which may provide support for multi-faceted environmental modifications in asthma prevention and control, and data to inform the potential impact of broad public health interventions. The birth cohort that this application supports is the Vanderbilt CANOE (Childhood Allergy and the NeOnatal Environment) study. CANOE is a birth cohort designed to identify and understand how environmental factors modify the development of the airway epithelium. The study includes the unique longitudinal sampling of the child airway throughout the first year of life, and annually. The Vanderbilt CANOE study has unique early life exposure and outcomes ascertainment, including surveillance for RSV and a novel biospecimen repository of nasal airway epithelial cells. The CANOE cohort also has important information for longitudinal development of the airway microbiome and the airway epithelium. The proposed research is innovative and timely given the anticipated licensure of multiple RSV prevention products in the coming year (maternal vaccines and long- acting monoclonal antibodies for infants). The proposed work represents a novel, multi-faceted approach to identifying and understanding the influence of severity of RSV infection and age of RSV infection on asthma risk and lung function. The answers to these questions will be critical to developing prevention strategies and informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may not only bolster RSV vaccine acceptability and uptake in the US, but will almost certainly be useful in evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.", "keywords": [ "2 year old", "Address", "Age", "Asthma", "Biological Process", "Biological Specimen Banks", "Birth", "Black Populations", "Bronchiolitis", "COVID-19 pandemic", "Child", "Child Health", "Childhood", "Childhood Acute Lymphocytic Leukemia", "Childhood Asthma", "Cohort Studies", "Collection", "Communities", "Conceptions", "Data", "Data Element", "Development", "Diagnosis", "Disease", "Enrollment", "Environment", "Environmental Exposure", "Environmental Risk Factor", "Epithelial Cells", "Funding", "Goals", "Hispanic Populations", "Hypersensitivity", "Incidence", "Individual", "Infant", "Infection", "Infrastructure", "Intervention", "Licensure", "Life", "Medical History", "Mentors", "Modification", "Monoclonal Antibodies", "Neonatal", "Nose", "Outcome", "Participant", "Population", "Predisposition", "Pregnant Women", "Prevention", "Prevention strategy", "Preventive", "Primary Prevention", "Protocols documentation", "Public Health", "Publications", "Recommendation", "Recurrence", "Research", "Research Personnel", "Respiratory Syncytial Virus Infections", "Respiratory Syncytial Virus Vaccines", "Respiratory syncytial virus", "Risk", "Rural Community", "Sampling", "Severities", "Southeastern United States", "Testing", "Urban Community", "Vaccines", "Wheezing", "Work", "age related", "airway epithelium", "asthma prevention", "chronic respiratory disease", "cohort", "cost-effectiveness evaluation", "design", "disorder prevention", "diversity and inclusion", "early life exposure", "ethnic diversity", "expectation", "follow-up", "infancy", "infant infection", "innovation", "interest", "low and middle-income countries", "middle childhood", "multi-racial", "novel", "pandemic disease", "pandemic impact", "policy implication", "pregnant", "prevent", "public health intervention", "pulmonary function", "racial diversity", "recruit", "resilience factor", "respiratory microbiome", "retention rate", "vaccine acceptance" ], "approved": true } }, { "type": "Grant", "id": "12081", "attributes": { "award_id": "1R21AI174050-01", "title": "NON-CANONICAL MECHANISMS FOR INTERFERON-LAMBDA REGULATION OF SARS-COV-2 INFECTION", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Allergy and Infectious Diseases (NIAID)" ], "program_reference_codes": [], "program_officials": [ { "id": 8224, "first_name": "Kentner L.", "last_name": "Singleton", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2025-08-31", "award_amount": 226254, "principal_investigator": { "id": 27938, "first_name": "Emily Ann", "last_name": "Hemann", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 778, "ror": "", "name": "OHIO STATE UNIVERSITY", "address": "", "city": "", "state": "OH", "zip": "", "country": "United States", "approved": true }, "abstract": "As the SARS-CoV-2 pandemic continues, a better understanding of the factors that regulate broadly protective immunity is needed. Interferon-lambda (IFN-λ) mediates antiviral protection against SARS-CoV-2 without causing overt pathology and exacerbated disease. As such, recombinant IFN-λ is in clinical trials as a therapeutic for COVID-19. However, the endogenous role for IFN-λ in regulating infection and functions in preventing disease beyond antiviral programming during SARS-CoV-2 remain unknown. Our preliminary data show that mice lacking the IFN-λ receptor (Ifnlr1-/-) have increased illness and viral burden during SARS-CoV-2 infection without alteration of canonical antiviral gene induction associated with IFN. Instead, IFN-λ positively regulates the induction of CD8 T cell immunity, a cellular immune response critical to mediating protection against virus infection when neutralizing antibody responses are avoided. We further identified upregulation of cell cycle repair and proliferation genes associated with fibrosis in Ifnlr1-/- mice. This proposal will investigate these newly identified non-canonical functions of IFN-λ in regulating immunity against SARS-CoV-2 with the goal of informing therapeutic use of this cytokine.", "keywords": [ "2019-nCoV", "Adoptive Transfer", "Antibody Response", "Body Weight decreased", "CD8-Positive T-Lymphocytes", "COVID-19", "COVID-19 pandemic", "COVID-19 prevention", "COVID-19 therapeutics", "Cell Cycle", "Cell Cycle Regulation", "Cell physiology", "Cells", "Clinical Trials", "Data", "Dendritic Cells", "Development", "Disease", "Epithelial Cell Proliferation", "Epithelial Cells", "FOXM1 gene", "Fibrosis", "Generations", "Genes", "Goals", "Histologic", "Human", "Immune response", "Immunity", "Immunologic Adjuvants", "Immunologic Factors", "Immunologist", "In Vitro", "Infection", "Influenza", "Influenza A virus", "Interferons", "Knock-out", "Knockout Mice", "Lung", "Lymphocytic Infiltrate", "Mediating", "Memory", "Mucous Membrane", "Mus", "Pathogenesis", "Pathology", "Pathway interactions", "Process", "Proliferating", "Recombinant Interferon", "Recombinants", "Recovery", "Regulation", "Research", "Role", "SARS-CoV-2 immunity", "SARS-CoV-2 infection", "SARS-CoV-2 inhibitor", "SARS-CoV-2 pathogenesis", "Seminal", "Signal Transduction", "Stains", "T cell response", "T-Cell Activation", "Therapeutic", "Therapeutic Uses", "Time", "Tissues", "Training", "Up-Regulation", "Vaccines", "Variant", "Viral", "Viral Genes", "Viral Load result", "Virus", "Virus Diseases", "Virus Replication", "Work", "adaptive immune response", "antiviral immunity", "cytokine", "draining lymph node", "epithelial repair", "experience", "experimental study", "gene induction", "immune activation", "improved", "in vivo", "innovation", "insight", "knockout animal", "mouse model", "neutralizing antibody", "novel", "pharmacologic", "post SARS-CoV-2 infection", "prevent", "programs", "receptor", "repaired", "respiratory infection virus", "respiratory virus", "response", "severe COVID-19", "therapeutically effective", "tissue repair" ], "approved": true } }, { "type": "Grant", "id": "12082", "attributes": { "award_id": "1R01CA276040-01A1", "title": "Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 27939, "first_name": "SHARON A.", "last_name": "ROSS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-08-31", "award_amount": 930383, "principal_investigator": { "id": 27940, "first_name": "Joshua Aiden", "last_name": "Hill", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 27941, "first_name": "MIGUEL-ANGEL", "last_name": "PERALES", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 2062, "ror": "", "name": "FRED HUTCHINSON CANCER CENTER", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "Chimeric antigen receptor T cell therapy (CARTx) has transformed treatment for B cell malignancies. However, the effects of CARTx on humoral immunity and infection risk are incompletely understood. The high prevalence of hypogammaglobulinemia in CARTx recipients has driven frequent use of prophylactic immunoglobulin G (IgG) replacement therapy (IGRT) to prevent infections in this patient population. However, limited data exist to support this practice, and shortages, side effects, and cost necessitate careful stewardship of IGRT. Emerging data indicate that pathogen-specific antibodies often persist after CD19-CARTx, potentially contesting the need for IGRT. Well controlled studies are needed to ascertain the clinical utility of IGRT in CARTx recipients. Within this clinical context, other important and connected questions remain about how IGRT affects CAR-T cell function, in addition to the possible costs versus benefits of the effect of IGRT on healthcare resource utilization. This timely and unique proposal will be the first randomized, controlled trial of IGRT use in CARTx recipients and provide critical insights into the potential risks and benefits of IGRT in this patient population. The key objectives of this study are to evaluate whether IGRT in CARTx recipients reduces infection rates compared to placebo, and to understand the impact of IGRT on previously unexplored outcomes such as CAR-T cell expansion, CAR- T cell persistence, CAR-T cell function, and healthcare resource utilization. For the proposed study, we have assembled an interdisciplinary group of physicians and scientists from high-volume CARTx centers who will leverage our expertise in immuno-oncology, infectious diseases, and cancer outcomes research. We propose a randomized trial of IGRT versus placebo in 150 adults with serum total IgG ≤400 mg/dL prior to CD19-CARTx. Participants will be randomized 1:1 to receive IGRT or placebo within 14 days prior to CARTx and at 28-day intervals after CARTx for 4 months. Aim 1 will compare between study arms the incidence rate of infections through 6 months after CD19-CARTx; we will also longitudinally characterize and compare total and pathogen-specific IgG levels and their association with infections. Aim 2 will explore the association of IGRT with healthcare resource utilization, cytokine release syndrome, and CARTx-associated neurotoxicity. Aim 3 will characterize the impact of IGRT on CAR-T cell expansion, persistence, and function. This will be the first randomized controlled study of IGRT after CARTx and will provide foundational data to establish evidence-based estimates of the clinical efficacy and risk-benefit of IGRT in CD19-CARTx recipients. In parallel, this study will explore other potential effects of IGRT on CAR-T cell dynamics and healthcare resource utilization. The data generated by this proposal will provide the groundwork for future studies to refine infection prevention strategies in the growing population of CARTx recipients.", "keywords": [ "Accounting", "Adoptive Immunotherapy", "Adult", "Adverse event", "Affect", "Antibiotics", "Antibodies", "B lymphoid malignancy", "Bacterial Infections", "Benefits and Risks", "Blood", "CAR T cell therapy", "CD19 gene", "Caring", "Cell Cycle Kinetics", "Cell Surface Proteins", "Cell physiology", "Cells", "Cessation of life", "Clinical", "Communicable Diseases", "Controlled Study", "Cox Models", "Cytometry", "Data", "Disease remission", "Double-Blind Method", "Dropout", "Emergency department visit", "Ensure", "Equity", "Future", "Health Resources", "Healthcare", "High Prevalence", "Hospitalization", "Humoral Immunities", "Image", "Immune", "Immunoglobulin G", "Immunoglobulins", "Immunooncology", "Incidence", "Infection", "Infection prevention", "Infusion procedures", "Intention", "Kinetics", "Life", "Lymphoma", "Malignant Neoplasms", "Measures", "Medical", "Medical Records", "Outcome", "Outcomes Research", "Outpatients", "Participant", "Patients", "Persons", "Pharmaceutical Preparations", "Physicians", "Placebos", "Population", "Prevention strategy", "Progression-Free Survivals", "Randomized", "Randomized Controlled Trials", "Recovery", "Replacement Therapy", "Resolution", "Resources", "Risk", "Scientist", "Serum", "Severities", "Signal Transduction", "Site", "Streptococcus pneumoniae", "Subgroup", "Toxic effect", "Visit", "arm", "cancer therapy", "chimeric antigen receptor T cells", "clinical efficacy", "clinical risk", "cost", "cytokine release syndrome", "design", "dimensional analysis", "evidence base", "follow-up", "hypogammaglobulinemia", "immune reconstitution", "infection rate", "infection risk", "insight", "neurotoxicity", "pathogen", "patient population", "placebo controlled study", "prophylactic", "radiological imaging", "randomized placebo controlled trial", "randomized trial", "randomized controlled study", "side effect", "tumor" ], "approved": true } }, { "type": "Grant", "id": "12083", "attributes": { "award_id": "1R01AG082892-01", "title": "Improving Care Transitions and Self-care among Informal Caregivers of Hospitalized Older Adults through Digital Tools", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20555, "first_name": "Melissa S", "last_name": "Gerald", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2028-05-31", "award_amount": 812042, "principal_investigator": { "id": 27942, "first_name": "KAREN B", "last_name": "HIRSCHMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 232, "ror": "https://ror.org/00b30xv10", "name": "University of Pennsylvania", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "Informal caregiving is demanding and stressful especially when dealing with a hospitalization. Many caregivers eventually become care recipients themselves as years of stress and deferred self-care put them at increased risk for illness. Self-care refers to the behaviors undertaken to maintain health and manage illness. Engaging in self-care may improve health status (physical functioning and mental well-being). Older adults with multiple chronic conditions (MCCs) often depend on caregivers for assistance, especially after a hospitalization, when caregivers are often expected to follow complicated discharge plans and manage complex skilled care at home. The impact of care gaps and breakdowns saps time for self-care and causes significant stress for caregivers. Health coaching, a support intervention, can improve self-care in patients, but studies evaluating caregivers and racial differences are limited. Less is known about the effect of caregiver support interventions on patient outcomes. Leveraging the growing availability and declining costs of technology and internet access—along with increasing receptivity of virtual care in the wake of COVID-19—we developed and tested a synchronous virtual support intervention, ViCCY (Virtual Caregiver Coach for You), where 10 video conference sessions are delivered by a trained coach over six months that focus on self-care, coping, and stress. In this application, we propose to augment the ViCCY protocol to target caregivers during an acute care episode (during/post- hospitalization) and transitions in care for older adults with MCCs compared to digital health information (DHI) alone (control group). Using a randomized controlled trial (RCT) design, we will enroll informal caregivers with poor self-care (Health Self-Care Neglect scale score ≥2), and block randomize the caregivers 1:1 to the intervention or control group, stratifying randomization by caregiver sex, race, and relationship to the patient. Both groups will receive DHI delivered through a website tailored with care transitions and self-care information, and the intervention group will also receive ViCCY. At baseline, 3-, and 6-months, we will collect self-reported data on self-care, stress, coping, and health status. At 1-month post-hospital discharge the care transitions experience will be collected. At 6-months, we will compare ViCCY to DHI alone to assess intervention efficacy using intent-to-treat analysis. A sample of 250 caregivers (125/arm) will provide >80% power to detect significant differences between the groups on the primary outcome of self-care (Aim 1) and that the magnitude of improvement will be similar in outcomes in Aim 1 between Black/AA and White caregivers (Aim 2). To explore the effect of caregiver outcomes on patients’ outcomes we will examine acute care resource use (rehospitalization, etc.) over a 6-month period (Aim 3). Knowing that not all patients will participate, we will consent a subgroup of the hospitalized older adults cared for by these caregivers (at least 40 dyads). If shown to be efficacious, our virtual health coaching intervention can easily scale to support millions of caregivers worldwide. This application addresses the NIA strategic plan and is in response to NOSI NOT-CA-22-037.", "keywords": [ "Acute", "Address", "African American", "Behavior", "Black race", "COVID-19", "Caregiver Burden", "Caregiver support", "Caregivers", "Caring", "Chronic", "Chronic Disease", "Communities", "Complex", "Consent", "Control Groups", "Data Reporting", "Discharge Plannings", "Economics", "Education", "Elderly", "Emergency department visit", "Enrollment", "Event", "Family member", "Goals", "Health", "Health Status", "Heart failure", "Home", "Hospitalization", "Hospitals", "Household", "Human", "Income", "Internet", "Intervention", "Loneliness", "Managed Care", "Measures", "Medicare", "Mental Health", "Modeling", "Nurses", "Outcome", "Participant", "Patient Care", "Patient Self-Report", "Patient-Focused Outcomes", "Patients", "Persons", "Physical Function", "Population", "Problem Solving", "Protocols documentation", "Race", "Randomized", "Randomized Controlled Trials", "Readiness", "Reporting", "Research", "Resources", "Risk", "Role", "Sampling", "Self Care", "Self Care outcome", "Self Efficacy", "Source", "Strategic Planning", "Stress", "Subgroup", "Technology", "Testing", "Time", "Training", "Treatment Efficacy", "Uncompensated Care", "Videoconferencing", "Visit", "Well in self", "Woman", "Work", "acute care", "arm", "care episode", "care recipients", "caregiver stress", "caregiving", "comparative efficacy", "comparison intervention", "coping", "coronavirus disease", "cost", "cost estimate", "digital health", "digital technology", "digital tool", "effectiveness evaluation", "experience", "group intervention", "hospital readmission", "improved", "improved outcome", "informal caregiver", "informal caregiving", "innovation", "interest", "intervention cost", "multiple chronic conditions", "neglect", "online resource", "perceived stress", "physical conditioning", "pre-pandemic", "primary outcome", "racial difference", "readmission rates", "response", "sex", "skills", "social", "social health determinants", "stress management", "symposium", "telephone delivery", "trial design", "urgent care", "virtual", "virtual health", "virtual healthcare", "web site" ], "approved": true } }, { "type": "Grant", "id": "12084", "attributes": { "award_id": "1RF1AG084178-01", "title": "Post-Acute Sequelae of SARS-CoV-2 Infection and Subsequent Disease Progression in Individuals with AD/ADRD: Influence of the Social and Environmental Determinants of Health", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 8882, "first_name": "PARTHA", "last_name": "BHATTACHARYYA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-01", "end_date": "2026-08-31", "award_amount": 2561480, "principal_investigator": { "id": 10734, "first_name": "Jiang", "last_name": "Bian", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 891, "ror": "https://ror.org/04b6nzv94", "name": "Brigham and Women's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 4802, "first_name": "Fei", "last_name": "Wang", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 686, "ror": "", "name": "Joan and Sanford I. Weill Medical College of Cornell University", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, { "id": 10736, "first_name": "Hui", "last_name": "Hu", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 891, "ror": "https://ror.org/04b6nzv94", "name": "Brigham and Women's Hospital", "address": "", "city": "", "state": "MA", "zip": "", "country": "United States", "approved": true }, "abstract": "The global pandemic of the 2019 novel coronavirus disease (COVID-19) has severe consequences. Recent studies showed that individuals with COVID-19 had increased risk of an array of postacute incident neurologic sequelae, including cognition and memory disorders, in 12 months after COVID-19 diagnosis. Despite elevated risks of postacute neurologic outcomes of COVID-19 observed in the general population, little is known about Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in cognitively impaired individuals (e.g., those with mild cognitive impairment [MCI] and Alzheimer’s disease [AD]/AD-related dementias [ADRD]) and how it may impact their subsequent disease progression. The rapid adoption of electronic health record (EHR) systems has made longitudinal clinical data available for research, especially for individuals with MCI or AD/ADRD who engage in frequent routine care. However, existing large EHR-based COVID-19 cohorts do not specifically focus on cognitively impaired individuals have several key limitations, including (1) missing or inaccurate information on cognitive impairment, (2) challenges to characterize disease progression in individuals with MCI or AD/ADRD, and (3) robust causal modeling approaches that can account for the complex confounding and selection biases in observational RWD. More importantly, little is known about factors contributing to PASC and subsequent disease progression in cognitively impaired individuals with COVID-19. It has long been recognized that social and environmental determinants of health (SEDH) play important roles in cognitive health. Exposures to multiple SEDH have been associated with MCI and AD/ADRD. Our recent studies (R21ES032762 and the RECOVER Initiative) also found that SEDH are associated with COVID-19 incidence, severity, mortality, and PASC in the general population. Individuals are exposed to multiple SEDH simultaneously, and the exposome is an ideal framework to rigorously examine how SEDH impacts cognitively impaired individuals’ susceptibility to PASC and subsequent disease progression. Building upon our prior and ongoing work on COVID-19 and PASC in the general population with the RECOVER Initiative, sub-phenotyping and disease progression modeling, and multiple SEDH, we will (1) understand the epidemiology of PASC in individuals with MCI or AD/ADRD with high-throughput causal inference approaches, (2) examine the impacts of COVID-19 and PASC on subsequent disease progression in individuals with MCI or AD/ADRD with a novel dynamic topic modeling approach, and (3) assess how SEDH contribute to PASC and subsequent disease progression in individuals with MCI or AD/ADRD with the exposome conceptual framework. This project will fill important knowledge gaps on our understanding of, especially SEDH’s contributions to, risks of PASC and subsequent disease progression in individuals with cognitive impairment.", "keywords": [ "2019-nCoV", "Acute", "Adoption", "Advanced Development", "Air Pollution", "Alabama", "Alzheimer&apos", "s Disease", "Alzheimer&apos", "s disease related dementia", "Antigens", "COVID-19", "COVID-19 diagnosis", "COVID-19 impact", "Clinical", "Clinical Data", "Cognition Disorders", "Cognitive", "Complex", "Connecticut", "Data", "Data Sources", "Dementia", "Disease Progression", "Electronic Health Record", "Environment", "Epidemiology", "Exposure to", "Florida", "Future", "General Population", "Health", "Heterogeneity", "Impaired cognition", "Incidence", "Individual", "Knowledge", "Laboratories", "Link", "Massachusetts", "Measures", "Medical History", "Medicine", "Memory Disorders", "Methods", "Modeling", "Nature", "Neighborhoods", "Neurologic", "Neurological outcome", "New Hampshire", "New Jersey", "New York", "Pathway interactions", "Patients", "Pattern", "Phenotype", "Play", "Polymerase Chain Reaction", "Positioning Attribute", "Post-Acute Sequelae of SARS-CoV-2 Infection", "Pragmatic clinical trial", "Predisposition", "Prevention strategy", "Publishing", "Research", "Risk", "Risk Factors", "Role", "SARS-CoV-2 positive", "Selection Bias", "Severities", "Social Environment", "Syndrome", "Testing", "Vital Statistics", "Work", "body system", "causal model", "cohort", "coronavirus disease", "data registry", "deep learning", "deprivation", "electronic health record system", "health determinants", "mild cognitive impairment", "mortality", "neurologic sequelae of COVID-19", "novel", "pandemic disease", "repository", "routine care", "social", "social influence", "success", "treatment strategy", "walkability" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1442, "count": 14420 } } }